The Global Global Surgical Booms Market 2018 by Manufacturers, Regions, Type and Application, Forecast to 2023: Surgical Booms Market Report middlemost ...
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Τετάρτη 19 Δεκεμβρίου 2018
2018-2023 Global Surgical Booms Market Strategy Analysis and Market Product Type - Blue Bird Magazine
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Low-Dose Perfusion Computed Tomography for Breast Cancer to Quantify Tumor Vascularity: Correlation With Prognostic Biomarkers
Objectives The aim of this study was to investigate the feasibility of using low-dose perfusion computed tomography (CT) in breast cancers for quantification of tumor vascularity and to correlate perfusion indexes with prognostic biomarkers. Materials and Methods This preliminary study was approved by our institutional review board. Signed informed consent was obtained from all 70 enrolled patients with invasive breast cancers. Low-dose perfusion CT was performed with the patient in the prone position using a spectral CT device set at 80 kVp and 30 mAs (1.30–1.40 mSv). Images were analyzed using commercial software applying the maximum slope algorithm. On CT perfusion maps, perfusion (mL/min per 100 mL), blood volume (mL/100 g), time-to-peak enhancement (second), and peak enhancement intensity (HU) were measured in the tumor, normal breast glandular tissues, and fat. Tumor grade, estrogen receptor (ER), human epidermal growth factor receptor 2 (HER2), and Ki67 level were evaluated using histopathology. Statistically, CT perfusion indexes of the tumor and normal glandular tissues or fat were compared using the Wilcoxon signed-rank test, and CT indexes were correlated with histological characteristics using the Mann-Whitney U or Kruskal-Wallis tests. We also correlated CT indexes with magnetic resonance imaging enhancement characteristics. Results In breast cancers, perfusion, blood volume, and peak enhancement intensity values were significantly higher, and time to peak was shorter than in normal glandular tissues and fat (P
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Hepatic Critical Care
Alternatives for Pediatric Anticoagulation: The Case for Bivalirudin
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In Response
Are Peripheral Nerve Blocks Indicated in Ambulatory Knee Surgery?
Enhanced Recovery Pathways: Looking Into the Future
Accelerated Segmented Diffusion-Weighted Prostate Imaging for Higher Resolution, Higher Geometric Fidelity, and Multi-b Perfusion Estimation
Purpose The aim of this study was to improve the geometric fidelity and spatial resolution of multi-b diffusion-weighted magnetic resonance imaging of the prostate. Materials and Methods An accelerated segmented diffusion imaging sequence was developed and evaluated in 25 patients undergoing multiparametric magnetic resonance imaging examinations of the prostate. A reduced field of view was acquired using an endorectal coil. The number of sampled diffusion weightings, or b-factors, was increased to allow estimation of tissue perfusion based on the intravoxel incoherent motion (IVIM) model. Apparent diffusion coefficients measured with the proposed segmented method were compared with those obtained with conventional single-shot echo-planar imaging (EPI). Results Compared with single-shot EPI, the segmented method resulted in faster acquisition with 2-fold improvement in spatial resolution and a greater than 3-fold improvement in geometric fidelity. Apparent diffusion coefficient values measured with the novel sequence demonstrated excellent agreement with those obtained from the conventional scan (R2 = 0.91 for bmax = 500 s/mm2 and R2 = 0.89 for bmax = 1400 s/mm2). The IVIM perfusion fraction was 4.0% ± 2.7% for normal peripheral zone, 6.6% ± 3.6% for normal transition zone, and 4.4% ± 2.9% for suspected tumor lesions. Conclusions The proposed accelerated segmented prostate diffusion imaging sequence achieved improvements in both spatial resolution and geometric fidelity, along with concurrent quantification of IVIM perfusion. Received for publication July 20, 2018; and accepted for publication, after revision, October 15, 2018. Conflicts of interest and sources of funding: Financial support from NIH grants R01 CA160902, R01 EB010195, R01 CA149342, R25 CA89017, and P41 EB015898 as well as TUBITAK 116C024, ALFGBG-727661, and CAN 2017/558 is acknowledged. Correspondence to: Stephan E. Maier, MD, PhD, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115. E-mail: stephan@bwh.harvard.edu. Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.
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Predatory Journals Undermine Peer Review and Cheapen Scholarship
Low-Dose Perfusion Computed Tomography for Breast Cancer to Quantify Tumor Vascularity: Correlation With Prognostic Biomarkers
Objectives The aim of this study was to investigate the feasibility of using low-dose perfusion computed tomography (CT) in breast cancers for quantification of tumor vascularity and to correlate perfusion indexes with prognostic biomarkers. Materials and Methods This preliminary study was approved by our institutional review board. Signed informed consent was obtained from all 70 enrolled patients with invasive breast cancers. Low-dose perfusion CT was performed with the patient in the prone position using a spectral CT device set at 80 kVp and 30 mAs (1.30–1.40 mSv). Images were analyzed using commercial software applying the maximum slope algorithm. On CT perfusion maps, perfusion (mL/min per 100 mL), blood volume (mL/100 g), time-to-peak enhancement (second), and peak enhancement intensity (HU) were measured in the tumor, normal breast glandular tissues, and fat. Tumor grade, estrogen receptor (ER), human epidermal growth factor receptor 2 (HER2), and Ki67 level were evaluated using histopathology. Statistically, CT perfusion indexes of the tumor and normal glandular tissues or fat were compared using the Wilcoxon signed-rank test, and CT indexes were correlated with histological characteristics using the Mann-Whitney U or Kruskal-Wallis tests. We also correlated CT indexes with magnetic resonance imaging enhancement characteristics. Results In breast cancers, perfusion, blood volume, and peak enhancement intensity values were significantly higher, and time to peak was shorter than in normal glandular tissues and fat (P
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Repeated Morphine Prolongs Postoperative Pain in Male Rats
BACKGROUND: Opioids are effective postoperative analgesics. Disturbingly, we have previously reported that opioids such as morphine can worsen inflammatory pain and peripheral and central neuropathic pain. These deleterious effects are mediated by immune mediators that promote neuronal hyperexcitability in the spinal dorsal horn. Herein, we tested whether perioperative morphine could similarly prolong postoperative pain in male rats. METHODS: Rats were treated with morphine for 7 days, beginning immediately after laparotomy, while the morphine was tapered in a second group. Expression of genes for inflammatory mediators was quantified in the spinal dorsal horn. In the final experiment, morphine was administered before laparotomy for 7 days. RESULTS: We found that morphine treatment after laparotomy extended postoperative pain by more than 3 weeks (time × treatment: Pfrom #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2QHI1l1
Total Intravenous Anesthetic Versus Inhaled Anesthetic: Pick Your Poison
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Should Total Intravenous Anesthesia Be Used to Prevent the Occupational Waste Anesthetic Gas Exposure of Pregnant Women in Operating Rooms?
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The More You Know: Identifying Factors Associated With Inpatient Mortality Related to Opioid Overdose Can Drive Progress in the Opioid Health Crisis
Liver Anesthesiology and Critical Care Medicine, 2nd ed
Clinical Practice Improvement: Mind the Gap or Fall Into the Chasm
Hepatic Critical Care
Hospital-Based Acute Care Within 7 Days of Discharge After Outpatient Arthroscopic Shoulder Surgery: Erratum
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Alternatives for Pediatric Anticoagulation: The Case for Bivalirudin
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In Response
Psychometrics: Trust, but Verify
There is a continued mandate for practicing evidence-based medicine and the prerequisite rigorous analysis of the comparative effectiveness of alternative treatments. There is also an increasing emphasis on delivering value-based health care. Both these high priorities and their related endeavors require correct information about the outcomes of care. Accurately measuring and confirming health care outcomes are thus likely now of even greater importance. The present basic statistical tutorial focuses on the germane topic of psychometrics. In its narrower sense, psychometrics is the science of evaluating the attributes of such psychological tests. However, in its broader sense, psychometrics is concerned with the objective measurement of the skills, knowledge, and abilities, as well as the subjective measurement of the interests, values, and attitudes of individuals—both patients and their clinicians. While psychometrics is principally the domain and content expertise of psychiatry, psychology, and social work, it is also very pertinent to patient care, education, and research in anesthesiology, perioperative medicine, critical care, and pain medicine. A key step in selecting an existing or creating a new health-related assessment tool, scale, or survey is confirming or establishing the usefulness of the existing or new measure; this process conventionally involves assessing its reliability and its validity. Assessing reliability involves demonstrating that the measurement instrument generates consistent and hence reproducible results—in other words, whether the instrument produces the same results each time it is used in the same setting, with the same type of subjects. This includes interrater reliability, intrarater reliability, test–retest reliability, and internal reliability. Assessing validity is answering whether the instrument is actually measuring what it is intended to measure. This includes content validity, criterion validity, and construct validity. In evaluating a reported set of research data and its analyses, in a similar manner, it is important to assess the overall internal validity of the attendant study design and the external validity (generalizability) of its findings.
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Enhanced Recovery Pathways: Looking Into the Future
Foretelling Right Ventricular Failure After Left Ventricular Assist Device Implantation: The Tale of the Pulmonary Artery Pulsatility Index
In Reply: Encouraging a Bare Minimum While Striving for the Gold Standard: A Response to the Updated WHO-WFSA Guidelines
Predatory Journals Undermine Peer Review and Cheapen Scholarship
Repeated Morphine Prolongs Postoperative Pain in Male Rats
BACKGROUND: Opioids are effective postoperative analgesics. Disturbingly, we have previously reported that opioids such as morphine can worsen inflammatory pain and peripheral and central neuropathic pain. These deleterious effects are mediated by immune mediators that promote neuronal hyperexcitability in the spinal dorsal horn. Herein, we tested whether perioperative morphine could similarly prolong postoperative pain in male rats. METHODS: Rats were treated with morphine for 7 days, beginning immediately after laparotomy, while the morphine was tapered in a second group. Expression of genes for inflammatory mediators was quantified in the spinal dorsal horn. In the final experiment, morphine was administered before laparotomy for 7 days. RESULTS: We found that morphine treatment after laparotomy extended postoperative pain by more than 3 weeks (time × treatment: Pfrom #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2QHI1l1
Total Intravenous Anesthetic Versus Inhaled Anesthetic: Pick Your Poison
No abstract availablefrom #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2BtQL3N
Should Total Intravenous Anesthesia Be Used to Prevent the Occupational Waste Anesthetic Gas Exposure of Pregnant Women in Operating Rooms?
No abstract availablefrom #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2QHHZJV
The More You Know: Identifying Factors Associated With Inpatient Mortality Related to Opioid Overdose Can Drive Progress in the Opioid Health Crisis
Liver Anesthesiology and Critical Care Medicine, 2nd ed
Clinical Practice Improvement: Mind the Gap or Fall Into the Chasm
Labor Pain’s Relationship With Depression: From Whence, and What Shall be Done?
Intraoperative Hemodynamic and Echocardiographic Measurements Associated With Severe Right Ventricular Failure After Left Ventricular Assist Device Implantation
BACKGROUND: Severe right ventricular failure (RVF) after left ventricular assist device (LVAD) implantation increases morbidity and mortality. We investigated the association between intraoperative right heart hemodynamic data, echocardiographic parameters, and severe versus nonsevere RVF. METHODS: A review of LVAD patients between March 2013 and March 2016 was performed. Severe RVF was defined by the need for a right ventricular mechanical support device, inotropic, and/or inhaled pulmonary vasodilator requirements for >14 days. From a chart review, the right ventricular failure risk score was calculated and right heart hemodynamic data were collected. Pulmonary artery pulsatility index (PAPi) [(pulmonary artery systolic pressure − pulmonary artery diastolic pressure)/central venous pressure (CVP)] was calculated for 2 periods: (1) 30 minutes before cardiopulmonary bypass (CPB) and (2) after chest closure. Echocardiographic data were recorded pre-CPB and post-CPB by a blinded reviewer. Univariate logistic regression models were used to examine the performance of hemodynamic and echocardiographic metrics. RESULTS: A total of 110 LVAD patients were identified. Twenty-five did not meet criteria for RVF. Of the remaining 85 patients, 28 (33%) met criteria for severe RVF. Hemodynamic factors associated with severe RVF included: higher CVP values after chest closure (18 ± 9 vs 13 ± 5 mm Hg; P = .0008) in addition to lower PAPi pre-CPB (1.2 ± 0.6 vs 1.7 ± 1.0; P = .04) and after chest closure (0.9 ± 0.5 vs 1.5 ± 0.8; P = .0008). Post-CPB echocardiographic findings associated with severe RVF included: larger right atrial diameter major axis (5.4 ± 0.9 vs 4.9 ± 1.0 cm; P = .03), larger right ventricle end-systolic area (22.6 ± 8.4 vs 18.5 ± 7.9 cm2; P = .03), lower fractional area of change (20.2 ± 10.8 vs 25.9 ± 12.6; P = .04), and lower tricuspid annular plane systolic excursion (0.9 ± 0.2 vs 1.1 ± 0.3 cm; P = .008). Right ventricular failure risk score was not a significant predictor of severe RVF. Post-chest closure CVP and post-chest closure PAPi discriminated severe from nonsevere RVF better than other variables measured, each with an area under the curve of 0.75 (95% CI, 0.64–0.86). CONCLUSIONS: Post-chest closure values of CVP and PAPi were significantly associated with severe RVF. Echocardiographic assessment of RV function post-CPB was weakly associated with severe RVF.from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Bs9wVe
In Response
Game Preview: Pens-Caps - NHL.com
Game Preview: Pens-Caps NHL.com
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Get the latest news and notes on the Pens as they prepare to take on the Caps in Washington.
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Game Preview: Pens-Caps - NHL.com
Game Preview: Pens-Caps NHL.com
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Get the latest news and notes on the Pens as they prepare to take on the Caps in Washington.
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Spatiotemporal variations of magnetic susceptibility in the deep gray matter nuclei from 1 month to 6 years: A quantitative susceptibility mapping study
Background
Quantitative susceptibility mapping (QSM) is emerging as a technique that quantifies the paramagnetic nonheme iron in brain tissue. Brain iron quantification during early development provides insights into the underlying mechanism of brain maturation.
Purpose
To quantify the spatiotemporal variations of brain iron‐related magnetic susceptibility in deep gray matter nuclei during early development by using QSM.
Study Type
Retrospective.
Subjects
Eighty‐seven infants and children aged 1 month to 6 years.
Field Strength/Sequence
Enhanced T2*‐weighted angiography using a 3D gradient‐echo sequence at 3.0T.
Assessment
QSM was calculated by modified sophisticated harmonic artifact reduction for phase data and sparse linear equations and sparse least squares‐based algorithm. Means of susceptibility in deep gray matter nuclei (caudate nucleus, putamen, globus pallidus, thalamus) relative to that in splenium of corpus callosum were measured.
Statistical Tests
Relationships of mean susceptibility with age and referenced iron concentration were tested by Pearson correlation. Differences of mean susceptibility between the selected nuclei in each age group were compared by one‐way analysis of variance (ANOVA) and Fisher's Linear Significant Difference (LSD) test.
Results
Positive correlations of susceptibility with both referenced iron concentration and age were found (P < 0.0001); particularly, globus pallidus showed the highest correlation with age (correlation coefficient, 0.882; slope, 1.203; P < 0.001) and greatest susceptibility (P < 0.05) among the selected nuclei.
Data Conclusion
QSM allows the feasible quantification of iron deposition in deep gray matter nuclei in infants and young children, which exhibited gradual accumulation at different speeds. The fastest and highest iron accumulation was observed in the globus pallidus with increasing age during early development.
Level of Evidence: 4
Technical Efficacy:Stage 2
J. Magn. Reson. Imaging 2018.
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UV regulates expression of phenylpropanoid biosynthesis genes in cucumber (Cucumis sativus L.) in an organ and spectrum dependent manner
Photochem. Photobiol. Sci., 2018, Accepted Manuscript
DOI: 10.1039/C8PP00480C, Paper
DOI: 10.1039/C8PP00480C, Paper
Minjie Qian, Irina Kalbina, Eva Rosenqvist, Marcel Jansen, Yuanwen Teng, Åke Strid
Expression of cucumber (Cucumis sativus) genes encoding the phenylpropanoid and flavonoid biosynthetic enzymes phenylalanine ammonia lyase (PAL), cinnamic acid 4-hydroxylase (C4H), and chalcone synthase (CHS), was studied under control light...
The content of this RSS Feed (c) The Royal Society of Chemistry
Expression of cucumber (Cucumis sativus) genes encoding the phenylpropanoid and flavonoid biosynthetic enzymes phenylalanine ammonia lyase (PAL), cinnamic acid 4-hydroxylase (C4H), and chalcone synthase (CHS), was studied under control light...
The content of this RSS Feed (c) The Royal Society of Chemistry
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Pre-Clinical Compartmental Pharmacokinetic Modeling of 2-[1-hexyloxyethyl]-2-Devinyl Pyropheophorbide-a (HPPH) a Photosensitizer in Rat Plasma by Validated HPLC Method
Photochem. Photobiol. Sci., 2018, Accepted Manuscript
DOI: 10.1039/C8PP00339D, Paper
DOI: 10.1039/C8PP00339D, Paper
Kowthavarapu v Krishna, Ranendra Narayan Saha, Anu Puri, Mathias Viard, Bruce A Shapiro, Sunil Kumar Dubey
A second-generation chlorin-based photosensitizer, 2-[1-hexyloxyethyl]-2-devinyl pyropheophorbide-a (HPPH) has shown tremendous therapeutic potential in clinical trials in treatment of esophageal cancer. Here, we have developed and validated a bioanalytical method for...
The content of this RSS Feed (c) The Royal Society of Chemistry
A second-generation chlorin-based photosensitizer, 2-[1-hexyloxyethyl]-2-devinyl pyropheophorbide-a (HPPH) has shown tremendous therapeutic potential in clinical trials in treatment of esophageal cancer. Here, we have developed and validated a bioanalytical method for...
The content of this RSS Feed (c) The Royal Society of Chemistry
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UV regulates expression of phenylpropanoid biosynthesis genes in cucumber (Cucumis sativus L.) in an organ and spectrum dependent manner
Photochem. Photobiol. Sci., 2018, Accepted Manuscript
DOI: 10.1039/C8PP00480C, Paper
DOI: 10.1039/C8PP00480C, Paper
Minjie Qian, Irina Kalbina, Eva Rosenqvist, Marcel Jansen, Yuanwen Teng, Åke Strid
Expression of cucumber (Cucumis sativus) genes encoding the phenylpropanoid and flavonoid biosynthetic enzymes phenylalanine ammonia lyase (PAL), cinnamic acid 4-hydroxylase (C4H), and chalcone synthase (CHS), was studied under control light...
The content of this RSS Feed (c) The Royal Society of Chemistry
Expression of cucumber (Cucumis sativus) genes encoding the phenylpropanoid and flavonoid biosynthetic enzymes phenylalanine ammonia lyase (PAL), cinnamic acid 4-hydroxylase (C4H), and chalcone synthase (CHS), was studied under control light...
The content of this RSS Feed (c) The Royal Society of Chemistry
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Pre-Clinical Compartmental Pharmacokinetic Modeling of 2-[1-hexyloxyethyl]-2-Devinyl Pyropheophorbide-a (HPPH) a Photosensitizer in Rat Plasma by Validated HPLC Method
Photochem. Photobiol. Sci., 2018, Accepted Manuscript
DOI: 10.1039/C8PP00339D, Paper
DOI: 10.1039/C8PP00339D, Paper
Kowthavarapu v Krishna, Ranendra Narayan Saha, Anu Puri, Mathias Viard, Bruce A Shapiro, Sunil Kumar Dubey
A second-generation chlorin-based photosensitizer, 2-[1-hexyloxyethyl]-2-devinyl pyropheophorbide-a (HPPH) has shown tremendous therapeutic potential in clinical trials in treatment of esophageal cancer. Here, we have developed and validated a bioanalytical method for...
The content of this RSS Feed (c) The Royal Society of Chemistry
A second-generation chlorin-based photosensitizer, 2-[1-hexyloxyethyl]-2-devinyl pyropheophorbide-a (HPPH) has shown tremendous therapeutic potential in clinical trials in treatment of esophageal cancer. Here, we have developed and validated a bioanalytical method for...
The content of this RSS Feed (c) The Royal Society of Chemistry
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Auransa Enters into Exclusive Licensing Agreement with China Oncology Focus Limited, an Affiliate of Lee's Pharmaceutical Holdings, for Rights to AU018 in Greater China and Southeast Asia - GlobeNewswire
Auransa Enters into Exclusive Licensing Agreement with China Oncology Focus Limited, an Affiliate of Lee's Pharmaceutical Holdings, for Rights to AU018 in Greater China and Southeast Asia GlobeNewswire
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Auransa to Receive Upfront Payment and be Eligible for Milestone Payments and Sales Royalties for Preclinical Program Identified by Company's AI-Driven ...
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A timeline of the cases of Meng Wanzhou and the Canadians detained in China - Coast Mountain News
A timeline of the cases of Meng Wanzhou and the Canadians detained in China Coast Mountain News
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A third Canadian has been detained in China since Huawei Technologies CFO was arrested in Vancouver.
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A qualitative literature review exploring the role of the inguinal ligament in the context of inguinal disruption management
Abstract
Purpose
Groin injury, sportsman's groin and inguinal disruption (ID) refer to a diffuse chronic groin pain syndrome that has significant impact on athletes and is often unresponsive to conservative management. The ID aetiology is poorly understood but may involve weakness of the inguinal ligament attachments or the posterior inguinal canal wall or the tendons of adductor longus and rectus abdominis. We discuss the literature in which the inguinal ligament was directly targeted for ID management in athletic populations. Secondarily, we discuss the anatomical reclassification of the inguinal ligament to a tendon based on the above information.
Methods
This was a qualitative review of the published literature, in English, from January 2007 to February 2017.
Results
Five research papers, including 264 patients, were appraised. In patients with ID, tears were identified in the inguinal ligament, and to relieve pain, the surgical treatment of the ligament by tenotomy was shown to be beneficial. Techniques such as radiofrequency denervation involving the inguinal ligament and ilioinguinal nerve were also shown to relieve symptoms in athletes.
Conclusions
This qualitative review has specifically focused on the literature directly targeting the inguinal ligament in ID which is a relatively unexplored management approach. When treated as a tendon, the inguinal ligament appears to be an appropriate ID therapeutic target. Integrated studies and randomised clinical trials will promote a better understanding of the role of the inguinal ligament and its tendinous properties in ID and provide a foundation for evidence-based management of chronic groin pain in athletes.
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A timeline of the cases of Meng Wanzhou and the Canadians detained in China - Coast Mountain News
A timeline of the cases of Meng Wanzhou and the Canadians detained in China Coast Mountain News
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A third Canadian has been detained in China since Huawei Technologies CFO was arrested in Vancouver.
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Interpace Diagnostics Group (IDXG) Given a $3.00 Price Target by HC Wainwright Analysts - PressOracle
Interpace Diagnostics Group (NASDAQ:IDXG) received a $3.00 price objective from research analysts at HC Wainwright in a note issued to investors on ...
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Exelixis, Inc. (NASDAQ:EXEL) Stake Raised by Russell Investments Group Ltd. - Fairfield Current
Russell Investments Group Ltd. lifted its position in shares of Exelixis, Inc. (NASDAQ:EXEL) by 295.6% in the third quarter, according to its most recent disclosure ...
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A qualitative literature review exploring the role of the inguinal ligament in the context of inguinal disruption management
Abstract
Purpose
Groin injury, sportsman's groin and inguinal disruption (ID) refer to a diffuse chronic groin pain syndrome that has significant impact on athletes and is often unresponsive to conservative management. The ID aetiology is poorly understood but may involve weakness of the inguinal ligament attachments or the posterior inguinal canal wall or the tendons of adductor longus and rectus abdominis. We discuss the literature in which the inguinal ligament was directly targeted for ID management in athletic populations. Secondarily, we discuss the anatomical reclassification of the inguinal ligament to a tendon based on the above information.
Methods
This was a qualitative review of the published literature, in English, from January 2007 to February 2017.
Results
Five research papers, including 264 patients, were appraised. In patients with ID, tears were identified in the inguinal ligament, and to relieve pain, the surgical treatment of the ligament by tenotomy was shown to be beneficial. Techniques such as radiofrequency denervation involving the inguinal ligament and ilioinguinal nerve were also shown to relieve symptoms in athletes.
Conclusions
This qualitative review has specifically focused on the literature directly targeting the inguinal ligament in ID which is a relatively unexplored management approach. When treated as a tendon, the inguinal ligament appears to be an appropriate ID therapeutic target. Integrated studies and randomised clinical trials will promote a better understanding of the role of the inguinal ligament and its tendinous properties in ID and provide a foundation for evidence-based management of chronic groin pain in athletes.
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Interpace Diagnostics Group (IDXG) Given a $3.00 Price Target by HC Wainwright Analysts - PressOracle
Interpace Diagnostics Group (NASDAQ:IDXG) received a $3.00 price objective from research analysts at HC Wainwright in a note issued to investors on ...
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Regulatory T Cells for More Targeted Immunosuppressive Therapies
There has been a prolific amount of research dedicated to the T-regulatory cells (Tregs) and their role in achieving immune homeostasis. Here, the authors briefly discuss the known biology, utilization, and potential of Tregs, for current trials and future immunotherapy. Most current trials of Treg therapies include either ex vivo expanded Tregs transferred into the peripheral blood of patients with diseases of immunologic origin or interleukin 2 injected to stimulate Tregs directly. Ongoing trials designed to measure the clinical efficacy and safety profile of these novel therapeutic approaches have resulted in largel y favorable outcomes in a variety of autoimmune and alloimmune diseases. (Source: Clinics in Laboratory Medicine)
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Exelixis, Inc. (NASDAQ:EXEL) Stake Raised by Russell Investments Group Ltd. - Fairfield Current
Russell Investments Group Ltd. lifted its position in shares of Exelixis, Inc. (NASDAQ:EXEL) by 295.6% in the third quarter, according to its most recent disclosure ...
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Auransa Enters into Exclusive Licensing Agreement with China Oncology Focus Limited, an Affiliate of Lee's Pharmaceutical Holdings, for Rights to AU018 in Greater China and Southeast Asia - GlobeNewswire
Auransa Enters into Exclusive Licensing Agreement with China Oncology Focus Limited, an Affiliate of Lee's Pharmaceutical Holdings, for Rights to AU018 in Greater China and Southeast Asia GlobeNewswire
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2R5WLtC
Auransa to Receive Upfront Payment and be Eligible for Milestone Payments and Sales Royalties for Preclinical Program Identified by Company's AI-Driven ...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2R5WLtC
Regulatory T Cells for More Targeted Immunosuppressive Therapies
There has been a prolific amount of research dedicated to the T-regulatory cells (Tregs) and their role in achieving immune homeostasis. Here, the authors briefly discuss the known biology, utilization, and potential of Tregs, for current trials and future immunotherapy. Most current trials of Treg therapies include either ex vivo expanded Tregs transferred into the peripheral blood of patients with diseases of immunologic origin or interleukin 2 injected to stimulate Tregs directly. Ongoing trials designed to measure the clinical efficacy and safety profile of these novel therapeutic approaches have resulted in largel y favorable outcomes in a variety of autoimmune and alloimmune diseases. (Source: Clinics in Laboratory Medicine)
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A six-mRNA prognostic model to predict survival in head and neck squam | CMAR - Dove Medical Press
Saisai Tian,1 Guofeng Meng,2 Weidong Zhang1,2 1Department of Phytochemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, ...
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A six-mRNA prognostic model to predict survival in head and neck squam | CMAR - Dove Medical Press
Saisai Tian,1 Guofeng Meng,2 Weidong Zhang1,2 1Department of Phytochemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, ...
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Differentiated Thyroid Cancer Therapeutics Market Demand is Increasing Rapidly in Recent Years!! - Paris Ledger
Differentiated Thyroid Cancer Therapeutics Market Demand is Increasing Rapidly in Recent Years!! Paris Ledger
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The "Differentiated Thyroid Cancer Therapeutics Market: Global Industry Analysis, Size, Share, Growth, Trends, and Forecasts 2016–2024" report that highlights ...
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Differentiated Thyroid Cancer Therapeutics Market Demand is Increasing Rapidly in Recent Years!! - Paris Ledger
Differentiated Thyroid Cancer Therapeutics Market Demand is Increasing Rapidly in Recent Years!! Paris Ledger
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The "Differentiated Thyroid Cancer Therapeutics Market: Global Industry Analysis, Size, Share, Growth, Trends, and Forecasts 2016–2024" report that highlights ...
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Fight to Protect Access to Habilitation Under the ACA
A federal judge's Dec.14 ruling that the Affordable Care Act (ACA) is unconstitutional and its provisions(such as essential health benefits and pre-existing condition protections) are invalid, complicates a regulatory scenario that already threatens consumers'access to habilitation and rehabilitation services. The judge did not,however, enjoin the law—meaning that the ACA is still the law. Whether this decision is ultimately upheld depends on the outcome of what is likely to be a lengthy appeals process that could end up at the U.S. Supreme Court. But habilitation and rehabilitation coverage is already threatened. The Centers for Medicare and Medicaid Services (CMS) issued regulations that give states greater flexibility in defining essential health benefits (EHBs) beginn...
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Neoantigen vaccine generates intratumoral T cell responses in phase Ib glioblastoma trial
Neoantigen vaccine generates intratumoral T cell responses in phase Ib glioblastoma trial, Published online: 19 December 2018; doi:10.1038/s41586-018-0792-9Neoantigen-targeting vaccines are a feasible therapy for tumours with a low mutation burden and immunologically 'cold' tumour microenvironment, as neoantigen-specific T cells from the peripheral blood migrate into intracranial glioblastoma, thereby altering the immune milieu of the glioblastoma. (Source: Nature AOP)
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Nonallergic Triggers and Comorbidities in Asthma Exacerbations and Disease Severity
Asthma triggers are exogenous or endogenous factors that could worsen asthma acutely to cause an exacerbation, or perpetuate chronic symptoms and airflow limitation. Because it is well known that recent asthma exacerbations and poor symptom control are strong predictors of future disease activity, it is not surprising that the number of (allergic or nonallergic) asthma triggers in the environment correlates with the disease-related quality of life. There is a need to identify and avoid specific triggers as the centerpiece of disease management, especially in those with heightened sensitivity to certain factors. (Source: Clinics in Chest Medicine)
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Neoantigen vaccine generates intratumoral T cell responses in phase Ib glioblastoma trial
Neoantigen vaccine generates intratumoral T cell responses in phase Ib glioblastoma trial, Published online: 19 December 2018; doi:10.1038/s41586-018-0792-9Neoantigen-targeting vaccines are a feasible therapy for tumours with a low mutation burden and immunologically 'cold' tumour microenvironment, as neoantigen-specific T cells from the peripheral blood migrate into intracranial glioblastoma, thereby altering the immune milieu of the glioblastoma. (Source: Nature AOP)
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Nonallergic Triggers and Comorbidities in Asthma Exacerbations and Disease Severity
Asthma triggers are exogenous or endogenous factors that could worsen asthma acutely to cause an exacerbation, or perpetuate chronic symptoms and airflow limitation. Because it is well known that recent asthma exacerbations and poor symptom control are strong predictors of future disease activity, it is not surprising that the number of (allergic or nonallergic) asthma triggers in the environment correlates with the disease-related quality of life. There is a need to identify and avoid specific triggers as the centerpiece of disease management, especially in those with heightened sensitivity to certain factors. (Source: Clinics in Chest Medicine)
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Wolverine sues 3M over PFAS contamination - Grand Haven Tribune
Wolverine sues 3M over PFAS contamination Grand Haven Tribune
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ROCKFORD — Wolverine Worldwide has filed a lawsuit in federal court against Scotchgard-maker 3M for potential damages caused to some Kent County ...
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Weight problems at fault for four % of cancers worldwide, examine says - Infosurhoy
Weight problems at fault for four % of cancers worldwide, examine says Infosurhoy
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WEDNESDAY, Dec. 12, 2018 — Overweight and obesity accounted for nearly 4 percent of all cancers globally in 2012, and that rate is likely to rise in coming ...
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A timeline of the cases of Meng Wanzhou and the Canadians detained in China - Calgary Herald
OTTAWA — A timeline of the Meng Wanzhou case, and rising tension between Canada and China.Aug. 22: A New York court issues a warrant for the arrest of ...
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Wolverine sues 3M over PFAS contamination - Grand Haven Tribune
Wolverine sues 3M over PFAS contamination Grand Haven Tribune
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ROCKFORD — Wolverine Worldwide has filed a lawsuit in federal court against Scotchgard-maker 3M for potential damages caused to some Kent County ...
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Weight problems at fault for four % of cancers worldwide, examine says - Infosurhoy
Weight problems at fault for four % of cancers worldwide, examine says Infosurhoy
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WEDNESDAY, Dec. 12, 2018 — Overweight and obesity accounted for nearly 4 percent of all cancers globally in 2012, and that rate is likely to rise in coming ...
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Fight to Protect Access to Habilitation Under the ACA
A federal judge's Dec.14 ruling that the Affordable Care Act (ACA) is unconstitutional and its provisions(such as essential health benefits and pre-existing condition protections) are invalid, complicates a regulatory scenario that already threatens consumers'access to habilitation and rehabilitation services. The judge did not,however, enjoin the law—meaning that the ACA is still the law. Whether this decision is ultimately upheld depends on the outcome of what is likely to be a lengthy appeals process that could end up at the U.S. Supreme Court. But habilitation and rehabilitation coverage is already threatened. The Centers for Medicare and Medicaid Services (CMS) issued regulations that give states greater flexibility in defining essential health benefits (EHBs) beginn...
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Fight to Protect Access to Habilitation Under the ACA
A federal judge's Dec.14 ruling that the Affordable Care Act (ACA) is unconstitutional and its provisions(such as essential health benefits and pre-existing condition protections) are invalid, complicates a regulatory scenario that already threatens consumers'access to habilitation and rehabilitation services. The judge did not,however, enjoin the law—meaning that the ACA is still the law. Whether this decision is ultimately upheld depends on the outcome of what is likely to be a lengthy appeals process that could end up at the U.S. Supreme Court. But habilitation and rehabilitation coverage is already threatened. The Centers for Medicare and Medicaid Services (CMS) issued regulations that give states greater flexibility in defining essential health benefits (EHBs) beginn...
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Opinion: Mich. needs high environmental standards - The Detroit News
"If Michigan is forced to rely on minimum protections from the federal government, it will severely limit our ability to act in the future."
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RESPONSE GENETICS INC (OTCMKTS:RGDXQ) Shorts Reduced By 94.5% - The EN Bulletin
RESPONSE GENETICS INC (OTCMKTS:RGDXQ) Shorts Reduced By 94.5% The EN Bulletin
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It was noted a decrease on RESPONSE GENETICS INC (OTCMKTS:RGDXQ)'s shares shorted with 94.5%. FINRA issued shares shorted of RGDXQ's total 6300 ...
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A timeline of the cases of Meng Wanzhou and the Canadians detained in China - Squamish Chief
A timeline of the cases of Meng Wanzhou and the Canadians detained in China Squamish Chief
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OTTAWA — A timeline of the Meng Wanzhou case, and rising tension between Canada and China.Aug. 22: A New York court issues a warrant for the arrest of ...
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Opinion: Mich. needs high environmental standards - The Detroit News
"If Michigan is forced to rely on minimum protections from the federal government, it will severely limit our ability to act in the future."
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Weight problems at fault for four % of cancers worldwide, examine says - Infosurhoy
Weight problems at fault for four % of cancers worldwide, examine says Infosurhoy
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WEDNESDAY, Dec. 12, 2018 — Overweight and obesity accounted for nearly 4 percent of all cancers globally in 2012, and that rate is likely to rise in coming ...
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Competitive Market of Anaplastic Thyroid Cancer from 2018 – 2026 - The Industry Chronicle
Competitive Market of Anaplastic Thyroid Cancer from 2018 – 2026 The Industry Chronicle
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"Anaplastic Thyroid Cancer Market Research Report 2018" provides information on Leading Key Players, Verticals, Countries, Technology, Application, and.
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RESPONSE GENETICS INC (OTCMKTS:RGDXQ) Shorts Reduced By 94.5% - The EN Bulletin
RESPONSE GENETICS INC (OTCMKTS:RGDXQ) Shorts Reduced By 94.5% The EN Bulletin
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It was noted a decrease on RESPONSE GENETICS INC (OTCMKTS:RGDXQ)'s shares shorted with 94.5%. FINRA issued shares shorted of RGDXQ's total 6300 ...
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A timeline of the cases of Meng Wanzhou and the Canadians detained in China - Squamish Chief
A timeline of the cases of Meng Wanzhou and the Canadians detained in China Squamish Chief
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OTTAWA — A timeline of the Meng Wanzhou case, and rising tension between Canada and China.Aug. 22: A New York court issues a warrant for the arrest of ...
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Dyspepsia Industry Overview 2018; Growing Prevalence of Chronic Diseases Has Fuelled the Growth of the Market by 2023 - Press Release - Digital Journal
Dyspepsia Industry Overview 2018; Growing Prevalence of Chronic Diseases Has Fuelled the Growth of the Market by 2023 - Press Release Digital Journal
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This press release was orginally distributed by SBWire. Pune, India -- (SBWIRE) -- 12/19/2018 -- Market Scenario. The Global Dyspepsia Market is expected to ...
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Fight to Protect Access to Habilitation Under the ACA
A federal judge's Dec.14 ruling that the Affordable Care Act (ACA) is unconstitutional and its provisions(such as essential health benefits and pre-existing condition protections) are invalid, complicates a regulatory scenario that already threatens consumers'access to habilitation and rehabilitation services. The judge did not,however, enjoin the law—meaning that the ACA is still the law. Whether this decision is ultimately upheld depends on the outcome of what is likely to be a lengthy appeals process that could end up at the U.S. Supreme Court. But habilitation and rehabilitation coverage is already threatened. The Centers for Medicare and Medicaid Services (CMS) issued regulations that give states greater flexibility in defining essential health benefits (EHBs) beginn...
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FDA Approves Pembrolizumab in Merkel Cell Carcinoma - OncLive
The FDA has granted an accelerated approval to pembrolizumab for the treatment of adult and pediatric patients with recurrent locally advanced or metastatic ...
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Keytruda Extends Lives of Advanced Head and Neck Cancer Patients in Phase 3 Trial, Data Show - Immuno-Oncology News
Keytruda Extends Lives of Advanced Head and Neck Cancer Patients in Phase 3 Trial, Data Show Immuno-Oncology News
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A Phase 3 trial reports Keytruda is better than standard treatment at extending in meaningful ways the lives of advanced neck and head SCC patients.
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FDA Approves Pembrolizumab in Merkel Cell Carcinoma - OncLive
The FDA has granted an accelerated approval to pembrolizumab for the treatment of adult and pediatric patients with recurrent locally advanced or metastatic ...
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Keytruda Extends Lives of Advanced Head and Neck Cancer Patients in Phase 3 Trial, Data Show - Immuno-Oncology News
Keytruda Extends Lives of Advanced Head and Neck Cancer Patients in Phase 3 Trial, Data Show Immuno-Oncology News
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A Phase 3 trial reports Keytruda is better than standard treatment at extending in meaningful ways the lives of advanced neck and head SCC patients.
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Comparison of Primary and Secondary Anterior Septal Reconstruction: A Cohort Study
Facial plast Surg
DOI: 10.1055/s-0038-1667154
This article compares outcomes in patients presenting for either primary or secondary (revision) anterior septal reconstruction (ASR) to treat caudal septal deviation. Patients undergoing ASR by senior author (S. P. M.) between January 1, 2012 and September 1, 2017, with both preoperative and postoperative Nasal Obstruction Symptom Evaluation (NOSE) scores documented in the chart were included. Data were compared between patients undergoing primary and secondary ASR by univariable and multivariable logistic regression. A total of 199 patients were included in this study; 128 (64%) underwent primary ASR and 71 (36%) underwent secondary ASR. After multivariable analysis, a greater ratio of females and autologous rib graft harvest in the secondary compared with primary ASR, and decreased odds of inferior turbinate reduction in the secondary group was found. There was no significant difference in NOSE scores between the primary and secondary group, and there were very few complications or revision surgeries. While outcomes are similar between primary and secondary (revision) ASR to treat caudal septal deviation, there was a significantly higher rate of autologous rib harvest, highlighting the importance of addressing deviations of the caudal septum at the primary procedure to reduce morbidity related to rib graft harvest and revision surgery.
[...]
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
Article in Thieme eJournals:
Table of contents | Abstract | Full text
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Comparison of Primary and Secondary Anterior Septal Reconstruction: A Cohort Study
Facial plast Surg
DOI: 10.1055/s-0038-1667154
This article compares outcomes in patients presenting for either primary or secondary (revision) anterior septal reconstruction (ASR) to treat caudal septal deviation. Patients undergoing ASR by senior author (S. P. M.) between January 1, 2012 and September 1, 2017, with both preoperative and postoperative Nasal Obstruction Symptom Evaluation (NOSE) scores documented in the chart were included. Data were compared between patients undergoing primary and secondary ASR by univariable and multivariable logistic regression. A total of 199 patients were included in this study; 128 (64%) underwent primary ASR and 71 (36%) underwent secondary ASR. After multivariable analysis, a greater ratio of females and autologous rib graft harvest in the secondary compared with primary ASR, and decreased odds of inferior turbinate reduction in the secondary group was found. There was no significant difference in NOSE scores between the primary and secondary group, and there were very few complications or revision surgeries. While outcomes are similar between primary and secondary (revision) ASR to treat caudal septal deviation, there was a significantly higher rate of autologous rib harvest, highlighting the importance of addressing deviations of the caudal septum at the primary procedure to reduce morbidity related to rib graft harvest and revision surgery.
[...]
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
Article in Thieme eJournals:
Table of contents | Abstract | Full text
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Disparities in NOSE Scores and Surgical Approaches among Patients Undergoing Functional Rhinoplasty
Facial plast Surg
DOI: 10.1055/s-0038-1676051
Social determinants of health have been widely studied throughout medicine; however, their role relating to functional rhinoplasty has not been previously evaluated. The records of 178 patients who underwent functional rhinoplasty in a single health network from 2013 to 2016 were reviewed. The Nasal Obstruction Symptom Evaluation (NOSE) score was used to assess patient-reported symptoms, and patients with both preoperative and postoperative NOSE scores were included in this study. Basic demographics and surgical techniques were also collected. Differences between NOSE scores and surgical approaches to functional rhinoplasty on the basis of insurance type were measured. One hundred and sixteen patients were included for analysis, the mean age was 34.7 years (standard deviation [SD] = 16.2) and 57 (49.1%) were female. Twenty-one (18.1%) patients had public insurance and, of these, 18 patients had Medicaid. Patients (mean, SD) with Medicaid insurance (56.39, 15.6) had a slightly greater improvement in NOSE scores compared with patients with non-Medicaid insurance (47.90, 25.6) (p = 0.067). There was no statistically significant difference in preoperative NOSE scores or postoperative improvement in NOSE scores between patients with different health insurance. Furthermore, there was no statistically significant difference in surgical approaches. The majority of patients receiving functional rhinoplasty had private insurance. Medicaid patients trended toward a greater NOSE score improvement after functional rhinoplasty, but also had a closer association with a history of nasal trauma and prior surgery. Future study is needed to better understand the association between socioeconomic status and disparities in care. Understanding how social determinants of health affect patients may reveal potential inherent biases, improve delivery of care, and translate to better patient outcomes.
[...]
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
Article in Thieme eJournals:
Table of contents | Abstract | Full text
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Disparities in NOSE Scores and Surgical Approaches among Patients Undergoing Functional Rhinoplasty
Facial plast Surg
DOI: 10.1055/s-0038-1676051
Social determinants of health have been widely studied throughout medicine; however, their role relating to functional rhinoplasty has not been previously evaluated. The records of 178 patients who underwent functional rhinoplasty in a single health network from 2013 to 2016 were reviewed. The Nasal Obstruction Symptom Evaluation (NOSE) score was used to assess patient-reported symptoms, and patients with both preoperative and postoperative NOSE scores were included in this study. Basic demographics and surgical techniques were also collected. Differences between NOSE scores and surgical approaches to functional rhinoplasty on the basis of insurance type were measured. One hundred and sixteen patients were included for analysis, the mean age was 34.7 years (standard deviation [SD] = 16.2) and 57 (49.1%) were female. Twenty-one (18.1%) patients had public insurance and, of these, 18 patients had Medicaid. Patients (mean, SD) with Medicaid insurance (56.39, 15.6) had a slightly greater improvement in NOSE scores compared with patients with non-Medicaid insurance (47.90, 25.6) (p = 0.067). There was no statistically significant difference in preoperative NOSE scores or postoperative improvement in NOSE scores between patients with different health insurance. Furthermore, there was no statistically significant difference in surgical approaches. The majority of patients receiving functional rhinoplasty had private insurance. Medicaid patients trended toward a greater NOSE score improvement after functional rhinoplasty, but also had a closer association with a history of nasal trauma and prior surgery. Future study is needed to better understand the association between socioeconomic status and disparities in care. Understanding how social determinants of health affect patients may reveal potential inherent biases, improve delivery of care, and translate to better patient outcomes.
[...]
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
Article in Thieme eJournals:
Table of contents | Abstract | Full text
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Use of Tissue Expander for Contracted Scarred Saddle Deformity Rhinoplasty
Facial plast Surg
DOI: 10.1055/s-0038-1675632
The main purpose of this article is to present an alternative technique for the reconstruction of saddle nose deformity in patients with severely scarred or contracted soft tissue envelopes. In this single surgeon case series, the authors present a two-staged reconstruction performed on four adult patients with saddle nose deformities and contracted soft tissue envelope stemming from a variety of etiologic factors including vasculitis, sarcoidosis, and trauma. Stage one involved placement of a 1 × 4 cm tissue expander along the nasal dorsum through anterior scalp and endonasal incisions. The tissue expander port was positioned under the anterior scalp and injected with saline over 3 weeks in-office. Stage two involved removal of the tissue expander and rhinoplasty using osteocartilaginous rib grafts. All four patients had successful expansion of the contracted soft tissue envelope, creating adequate space for the newly reconstructed nasal framework. One patient developed exposure of the tissue expander through the endonasal incision, which did not lead to any adverse outcome. All patients in this series tolerated expansion well, without complaints of pain or external skin breakdown. The use of soft tissue expanders along the nasal dorsum can successfully expand contracted and scarred soft tissue envelopes prior to reconstructive rhinoplasty. This technique may be an effective alternative to the use of interpolated flaps in treating these patients.
[...]
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
Article in Thieme eJournals:
Table of contents | Abstract | Full text
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Use of Tissue Expander for Contracted Scarred Saddle Deformity Rhinoplasty
Facial plast Surg
DOI: 10.1055/s-0038-1675632
The main purpose of this article is to present an alternative technique for the reconstruction of saddle nose deformity in patients with severely scarred or contracted soft tissue envelopes. In this single surgeon case series, the authors present a two-staged reconstruction performed on four adult patients with saddle nose deformities and contracted soft tissue envelope stemming from a variety of etiologic factors including vasculitis, sarcoidosis, and trauma. Stage one involved placement of a 1 × 4 cm tissue expander along the nasal dorsum through anterior scalp and endonasal incisions. The tissue expander port was positioned under the anterior scalp and injected with saline over 3 weeks in-office. Stage two involved removal of the tissue expander and rhinoplasty using osteocartilaginous rib grafts. All four patients had successful expansion of the contracted soft tissue envelope, creating adequate space for the newly reconstructed nasal framework. One patient developed exposure of the tissue expander through the endonasal incision, which did not lead to any adverse outcome. All patients in this series tolerated expansion well, without complaints of pain or external skin breakdown. The use of soft tissue expanders along the nasal dorsum can successfully expand contracted and scarred soft tissue envelopes prior to reconstructive rhinoplasty. This technique may be an effective alternative to the use of interpolated flaps in treating these patients.
[...]
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
Article in Thieme eJournals:
Table of contents | Abstract | Full text
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Contemporary Trends in the Surgical Management of Nasal Septal Perforations: A Community Survey
Facial plast Surg
DOI: 10.1055/s-0038-1676049
There currently exists an overabundance of publications advocating different septal perforation repair methods. The objective of this article was to examine the preponderance of techniques and trends in the surgical management of septal perforations in the practices of otolaryngologists, rhinologists, and facial plastic surgeons. The study was designed as a multicenter cross-sectional survey. The participants were members of the American Academy of Facial Plastic and Reconstructive Surgery and the American Rhinologic Society. Septal perforation closure rates and perforation repair approach, technique, and interposition graft material preferences were the main outcomes. A total of 320 respondents completed the survey, of whom 75% performed perforation repairs. The success rates in closing perforations < 1 cm, 1–2 cm, and > 2 cm were 84%, 64%, and 31%, respectively. The respondents had a similar preference for the endoscopic (52%) and external rhinoplasty (49%) approaches, followed by the endonasal approach (43%). Bilateral intranasal mucosal advancement flaps (79%) and unilateral intranasal mucosal rotational or advancement flaps (60%) were the favored repair techniques. Most respondents (84%) incorporated an interposition graft and intranasal splints (89%) for the repair, and the most popular interposition graft material was acellular dermis (63%). The self-reported perforation closure success rates in this survey were lower than those published in the literature, a phenomenon possibly explained by the premise that surgeons with favorable outcomes are more apt to share their results. The preferred surgical approach was evenly distributed between the external rhinoplasty and endoscopic approaches and influenced by a surgeon's training, perforation size and location, and the need for concomitant rhinoplasty. This study is the first to characterize contemporary community trends in the surgical closure of septal perforations and demonstrates that while preference for perforation repair approach among the respondents varied, surgeons favored septal perforation repair using bilateral intranasal mucosal advancement flaps with an interposition graft.
[...]
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
Article in Thieme eJournals:
Table of contents | Abstract | Full text
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2EDNxih
Contemporary Trends in the Surgical Management of Nasal Septal Perforations: A Community Survey
Facial plast Surg
DOI: 10.1055/s-0038-1676049
There currently exists an overabundance of publications advocating different septal perforation repair methods. The objective of this article was to examine the preponderance of techniques and trends in the surgical management of septal perforations in the practices of otolaryngologists, rhinologists, and facial plastic surgeons. The study was designed as a multicenter cross-sectional survey. The participants were members of the American Academy of Facial Plastic and Reconstructive Surgery and the American Rhinologic Society. Septal perforation closure rates and perforation repair approach, technique, and interposition graft material preferences were the main outcomes. A total of 320 respondents completed the survey, of whom 75% performed perforation repairs. The success rates in closing perforations < 1 cm, 1–2 cm, and > 2 cm were 84%, 64%, and 31%, respectively. The respondents had a similar preference for the endoscopic (52%) and external rhinoplasty (49%) approaches, followed by the endonasal approach (43%). Bilateral intranasal mucosal advancement flaps (79%) and unilateral intranasal mucosal rotational or advancement flaps (60%) were the favored repair techniques. Most respondents (84%) incorporated an interposition graft and intranasal splints (89%) for the repair, and the most popular interposition graft material was acellular dermis (63%). The self-reported perforation closure success rates in this survey were lower than those published in the literature, a phenomenon possibly explained by the premise that surgeons with favorable outcomes are more apt to share their results. The preferred surgical approach was evenly distributed between the external rhinoplasty and endoscopic approaches and influenced by a surgeon's training, perforation size and location, and the need for concomitant rhinoplasty. This study is the first to characterize contemporary community trends in the surgical closure of septal perforations and demonstrates that while preference for perforation repair approach among the respondents varied, surgeons favored septal perforation repair using bilateral intranasal mucosal advancement flaps with an interposition graft.
[...]
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
Article in Thieme eJournals:
Table of contents | Abstract | Full text
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Number of Pets in Infancy Tied to Lower Allergy Risk
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Cancer, Autoimmunity and Immunology 2019 (Day 1)
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Former President Of Billionaire-Owned Hearing Aid Manufacturer Sentenced To 7 Years In Prison
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Former President Of Billionaire-Owned Hearing Aid Manufacturer Sentenced To 7 Years In Prison
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Market Overview: Provides a unique tool for evaluating the Market, highlighting opportunities, and supporting strategic and tactical decision-making. This report ...
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Market Overview: Provides a unique tool for evaluating the Market, highlighting opportunities, and supporting strategic and tactical decision-making. This report ...
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Food Allergies Tied to MS Relapses
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The US surgeon general just issued a rare advisory about e-cigs like the Juul — here’s why vaping is so dangerous
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Detection of circulating HPV16 DNA as a biomarker in the blood of patients with human papillomavirus‐positive oropharyngeal squamous cell carcinoma
Abstract
Background
Development of biomarker analysis using the circulating cell‐free DNA (cfDNA) methodology is a challenge for noninvasive cancer diagnosis. In this study, a comparison between the plasma and tumor tissue HPV16 DNA viral loads (VLs) has been presented.
Methods
Real‐time polymerase chain reaction was performed for quantitating of HPV16 DNA in the plasma and tumor samples of patients with oropharyngeal cancer.
Results
Among the tissues, HPV16‐positive patients with oropharyngeal squamous cell carcinoma, nonsmoking patients, displayed significantly higher HPV16 DNA VLs in their tissue. No smoking and advanced N disease were the most important predictors for cHPV16 DNA (circulating HPV16 DNA) detection. The cHPV16‐positive women displayed significantly higher VLs in their tumor tissues compared to the men, although without notable impact on the blood detection.
Conclusions
Many factors were responsible for human papillomavirus DNA circulation in blood. As a result of the small size of the analyzed group, some observed discrepancies need to be proven on a larger cohort.
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A tiny patch with the potential to beat cancer - WFXL FOX 31
CINCINNATI (WKRC) - Local doctors are among the first in the country to test a potential new therapy to fight cancer that could change outcomes in ways never ...
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Unbelievable: U.S. agrees to give Mexico more than $10 billion but there are NO dollars for the border wall
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Detection of circulating HPV16 DNA as a biomarker in the blood of patients with human papillomavirus‐positive oropharyngeal squamous cell carcinoma
Abstract
Background
Development of biomarker analysis using the circulating cell‐free DNA (cfDNA) methodology is a challenge for noninvasive cancer diagnosis. In this study, a comparison between the plasma and tumor tissue HPV16 DNA viral loads (VLs) has been presented.
Methods
Real‐time polymerase chain reaction was performed for quantitating of HPV16 DNA in the plasma and tumor samples of patients with oropharyngeal cancer.
Results
Among the tissues, HPV16‐positive patients with oropharyngeal squamous cell carcinoma, nonsmoking patients, displayed significantly higher HPV16 DNA VLs in their tissue. No smoking and advanced N disease were the most important predictors for cHPV16 DNA (circulating HPV16 DNA) detection. The cHPV16‐positive women displayed significantly higher VLs in their tumor tissues compared to the men, although without notable impact on the blood detection.
Conclusions
Many factors were responsible for human papillomavirus DNA circulation in blood. As a result of the small size of the analyzed group, some observed discrepancies need to be proven on a larger cohort.
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