Peanut allergies: What is the best policy for schools?

Peanut allergies can be a serious problem, and many exposures happen when our kids are at school. On average, there are  probably about 5 peanut-allergic children in each of our nation's 100,000 school buildings. What's the best policy for schools to use to help protect these kids from potentially fatal reactions? Different schools have taken different approaches, […]Find jobs at  Careers by KevinMD.com.  Search thousands of physician, PA, NP, and CRNA jobs now.  Learn more. (Source: Kevin, M.D. - Medical Weblog)

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Peanut allergies: What is the best policy for schools?

Peanut allergies can be a serious problem, and many exposures happen when our kids are at school. On average, there are  probably about 5 peanut-allergic children in each of our nation's 100,000 school buildings. What's the best policy for schools to use to help protect these kids from potentially fatal reactions? Different schools have taken different approaches, […]Find jobs at  Careers by KevinMD.com.  Search thousands of physician, PA, NP, and CRNA jobs now.  Learn more. (Source: Kevin, M.D. - Medical Weblog)

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Asthma Drug Explored in SLE (CME/CE)

(MedPage Today) -- Anti-IgE antibody promising as add-on therapy in phase 1b study (Source: MedPage Today Allergy)

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The Association of 3-D Volume and 2-D Area of Post-swallow Pharyngeal Residue on CT Imaging

In conclusion, the area of post-swallow pharyngeal residue was associated with volume, with limitations in specific cases. Direct measurement of pharyngeal residue volume and swallowing physiology with 3D-CT can be used to validate results from standard 2D instrumentation. (Source: Dysphagia)

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Editorial Board

Publication date: January 2019Source: Lingua, Volume 218Author(s): (Source: Lingua)

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Language, Mobility and Belonging

Publication date: Available online 11 January 2019Source: Language & CommunicationAuthor(s): Kinga Kozminska, Leonie Schulte, Nancy Hawker, Rosemary Hall (Source: Language and Communication)

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Situation model building ability uniquely predicts first and second language reading comprehension

We examined the unique role of textbase memory and situation model building ability in first (L1) and second (L2) language reading comprehension. Participants were 76 monolingual and 102 bilingual children in 4th grade. A pathfinder network approach was used to assess textbase memory and situation model building ability, on top of other well-known cognitive and linguistic predictors of reading comprehension (working memory, nonverbal reasoning, decoding, vocabulary, and grammar). Reading comprehension was assessed by a standardized task unrelated to the textbase and situation model building task. The results showed that there was no difference between L1 and L2 readers in nonverbal reasoning, working memory, textbase memory and situation model building. L2 readers were more efficient decod...

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Distance-dependent memory for pictures and words

Publication date: April 2019Source: Journal of Memory and Language, Volume 105Author(s): Elinor Amit, SoYon Rim, Georg Halbeisen, Uriel Cohen Priva, Elena Stephan, Yaacov TropeAbstractThree experiments explored the effect of medium of presentation (pictures, words) and psychological distance (proximal, distal) on episodic memory. In particular, we predicted that memory would be better for congruent combinations of medium and distance (i.e., pictures of psychologically proximal entities and verbal labels of psychologically distal entities) than incongruent combinations (i.e., pictures of psychologically distal entities and verbal labels of psychologically proximal entities). Our results support this hypothesis. In Experiments 1 and 2, recall was better when medium and temporal distance were...

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Proximal and distal deictics and the construal of narrative time

Journal Name: Cognitive Linguistics Issue: Ahead of print (Source: Cognitive Linguistics)

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Lexico-grammatical alignment in metaphor construal

Journal Name: Cognitive Linguistics Issue: Ahead of print (Source: Cognitive Linguistics)

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The syntactic and semantic features of two-year-olds' verb vocabularies: a comparison of typically developing children and late talkers.

We examined syntactic (transitive, intransitive, ditransitive) and semantic (manner, result) features of two-year-olds' verb vocabularies, contrasting late talkers and typically developing children to look for early differences in verb vocabulary. We conducted a retrospective analysis of parent-reported expressive vocabulary from the Language Development Survey (N = 564, N(LT) = 62) (Rescorla, 1989). Verbs were coded for the presence or absence of each syntactic and semantic feature. Binomial mixed-effects regressions revealed the effect of feature on children's knowledge and whether feature interacted with group classification. Our results revealed mostly similarities between late talkers and typically developing children. All children's vocabularies showed a bias against verbs that occur...

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Vocal production and novel word learning in the first year.

This study focuses on the relationship between vocal production and new word learning. Thirty monolingual Italian-learning infants were recorded at about 11 months, to establish the extent of their consonant production. In parallel, the infants were trained on novel word-object pairs, two consisting of early learned consonants (ELC), two consisting of late learned consonants (LLC). Word learning was assessed through Preferential Looking. The results suggest that vocal production supports word learning: Only children with higher, consistent consonant production attended more to the trained ELC images. PMID: 30632478 [PubMed - as supplied by publisher] (Source: Journal of Child Language)

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Asthma Drug Explored in SLE (CME/CE)

(MedPage Today) -- Anti-IgE antibody promising as add-on therapy in phase 1b study (Source: MedPage Today Allergy)

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Editorial Board

Publication date: January 2019Source: Lingua, Volume 218Author(s): (Source: Lingua)

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Language, Mobility and Belonging

Publication date: Available online 11 January 2019Source: Language & CommunicationAuthor(s): Kinga Kozminska, Leonie Schulte, Nancy Hawker, Rosemary Hall (Source: Language and Communication)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2AMRIF7

Situation model building ability uniquely predicts first and second language reading comprehension

We examined the unique role of textbase memory and situation model building ability in first (L1) and second (L2) language reading comprehension. Participants were 76 monolingual and 102 bilingual children in 4th grade. A pathfinder network approach was used to assess textbase memory and situation model building ability, on top of other well-known cognitive and linguistic predictors of reading comprehension (working memory, nonverbal reasoning, decoding, vocabulary, and grammar). Reading comprehension was assessed by a standardized task unrelated to the textbase and situation model building task. The results showed that there was no difference between L1 and L2 readers in nonverbal reasoning, working memory, textbase memory and situation model building. L2 readers were more efficient decod...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2ST6roU

Distance-dependent memory for pictures and words

Publication date: April 2019Source: Journal of Memory and Language, Volume 105Author(s): Elinor Amit, SoYon Rim, Georg Halbeisen, Uriel Cohen Priva, Elena Stephan, Yaacov TropeAbstractThree experiments explored the effect of medium of presentation (pictures, words) and psychological distance (proximal, distal) on episodic memory. In particular, we predicted that memory would be better for congruent combinations of medium and distance (i.e., pictures of psychologically proximal entities and verbal labels of psychologically distal entities) than incongruent combinations (i.e., pictures of psychologically distal entities and verbal labels of psychologically proximal entities). Our results support this hypothesis. In Experiments 1 and 2, recall was better when medium and temporal distance were...

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Proximal and distal deictics and the construal of narrative time

Journal Name: Cognitive Linguistics Issue: Ahead of print (Source: Cognitive Linguistics)

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Lexico-grammatical alignment in metaphor construal

Journal Name: Cognitive Linguistics Issue: Ahead of print (Source: Cognitive Linguistics)

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Concept characteristics and variation in lexical diversity in two Dutch dialect areas

Journal Name: Cognitive Linguistics Issue: Ahead of print (Source: Cognitive Linguistics)

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The syntactic and semantic features of two-year-olds' verb vocabularies: a comparison of typically developing children and late talkers.

We examined syntactic (transitive, intransitive, ditransitive) and semantic (manner, result) features of two-year-olds' verb vocabularies, contrasting late talkers and typically developing children to look for early differences in verb vocabulary. We conducted a retrospective analysis of parent-reported expressive vocabulary from the Language Development Survey (N = 564, N(LT) = 62) (Rescorla, 1989). Verbs were coded for the presence or absence of each syntactic and semantic feature. Binomial mixed-effects regressions revealed the effect of feature on children's knowledge and whether feature interacted with group classification. Our results revealed mostly similarities between late talkers and typically developing children. All children's vocabularies showed a bias against verbs that occur...

MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2AMRv4N

Vocal production and novel word learning in the first year.

This study focuses on the relationship between vocal production and new word learning. Thirty monolingual Italian-learning infants were recorded at about 11 months, to establish the extent of their consonant production. In parallel, the infants were trained on novel word-object pairs, two consisting of early learned consonants (ELC), two consisting of late learned consonants (LLC). Word learning was assessed through Preferential Looking. The results suggest that vocal production supports word learning: Only children with higher, consistent consonant production attended more to the trained ELC images. PMID: 30632478 [PubMed - as supplied by publisher] (Source: Journal of Child Language)

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Vocal Fold Polyps: Literature Review

Int Arch Otorhinolaryngol 2019; 23: 116-124
DOI: 10.1055/s-0038-1675391

Introduction Vocal fold polyps are one of the most frequent benign laryngeal lesions, impacting the quality of life of those affected by them, primarily the vocal production. Despite being a well-established therapy in conjunction with surgery, speech therapy alone may also be effective in treating these lesions. As such, otolaryngologists and speech therapists need updated bibliographic knowledge on the issue. Objective To describe the literature findings on vocal fold polyps that discuss prevalence, etiology, histology, physiopathology, vocal characteristics or treatment. Data Synthesis The present study is a review article based on a bibliographic search using platforms, databases and search engines, with no restrictions on means of publication, methodological quality or language. All the articles on vocal fold polyps pertaining to the object of study published in the past 15 years were included. Among the characteristics investigated, the most discussed were prevalence of men, smoking as an etiological cofactor, the possibility of histological differentiation from vocal nodules, the relationship with cover minor structural alterations, and the indication and effectiveness of different treatment options. Conclusion Despite the discrepancies found in the present literature review on vocal fold polyps, there has been a notable scientific progress in the otolaryngologic techniques and in the effectiveness of speech therapy as initial treatment, with direct and indirect techniques, corroborating the need for scientific investigation of the issue.
[...]

Thieme Revinter Publicações Ltda Rio de Janeiro, Brazil

Article in Thieme eJournals:
Table of contents  |  Abstract  |  open access Full text

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Inhibitory checkpoint receptors control CD8+ resident memory T cells to prevent skin allergy

The present study confirms the crucial role of epidermal CD8+ Trm for the recurrences of allergic contact dermatitis and highlights the contribution of immune checkpoint receptors on CD8+ Trm to prevent eczema flares upon allergen exposure. (Source: Journal of Allergy and Clinical Immunology)

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Anaphylaxis After Vaccination Reported To The Vaccine Adverse Event Reporting System, 1990 –2016

Of persons with anaphylaxis (a potentially life-threatening condition) reported after vaccination, 49% had no history of hypersensitivity. Vaccine providers should be prepared to respond immediately to anaphylaxis occurring in any anyone who receives a vaccine. (Source: Journal of Allergy and Clinical Immunology)

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A monoallelic activating mutation in RAC2 resulting in a combined immunodeficiency

A heterozygous gain-of-function mutation in RAC2 is associated with an autosomal dominant combined immunodeficiency. (Source: Journal of Allergy and Clinical Immunology)

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Early life undernutrition reprograms CD4+ T-cell glycolysis and epigenetics to facilitate asthma

Nutrition is central to early life development. The maternal diet remodels cell-intrinsic glucose metabolism and epigenetic status within offspring T cells, resulting in exacerbated Th2 differentiation and susceptibility to asthma. (Source: Journal of Allergy and Clinical Immunology)

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Complexities in analyzing human basophil responses to auto-antibodies to IgE or Fc εRI

(Source: Journal of Allergy and Clinical Immunology)

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Prevalence of Eosinophilic Colitis and the Diagnoses Associated with Colonic Eosinophilia

Pediatric eosinophilic colitis (EC) is a rare disease with a prevalence of ∼1/63,000 individuals, and at our tertiary care pediatric medical center, only 2% of patients with the ICD-9/10 code for EC likely have the disease. (Source: Journal of Allergy and Clinical Immunology)

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Association between rhinovirus species and nasopharyngeal microbiota in infants with severe bronchiolitis

Among 774 infants with severe bronchiolitis, rhinovirus species related to distinct nasopharyngeal microbiota. Infants with rhinovirus-A were more likely to have Haemophilus-dominant microbiota profile, while those with rhinovirus-C were more likely to have Moraxella-dominant profile. (Source: Journal of Allergy and Clinical Immunology)

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IL-21 promotes allergic airway inflammation by driving apoptosis of FoxP3+ regulatory T cells

IL-21 indirectly sustains proinflammatory effector T cell responses by sensitizing FoxP3+ Tregs to caspase-dependent apoptosis. (Source: Journal of Allergy and Clinical Immunology)

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IFN- γ and CD25 drive distinct pathologic features during hemophagocytic lymphohistiocytosis

Inflammatory activation of CD8+ T cells can, when left unchecked, drive severe immunopathology. Hyperstimulation of CD8+ T cells through a broad set of triggering signals can precipitate hemophagocytic lymphohistiocytosis (HLH), a life-threatening systemic inflammatory disorder. (Source: Journal of Allergy and Clinical Immunology)

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Cytokine-induced endogenous production of prostaglandin D2 is essential for human group 2 innate lymphoid cell activation

Group 2 innate lymphoid cells (ILC2s) play a key role in the initiation and maintenance of type 2 immune responses. The prostaglandin (PG) D2 –chemoattractant receptor–homologous molecule expressed on TH2 cells (CRTH2) receptor axis potently induces cytokine production and ILC2 migration. (Source: Journal of Allergy and Clinical Immunology)

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Sublingual immunotherapy with the SQ tree SLIT-tablet is highly effective and well tolerated: results from a randomized, double-blind, placebo-controlled phase III trial

The trial demonstrated efficacy and safety of the SQ tree SLIT-tablet compared to placebo in adolescents and adults with moderate-severe birch pollen induced allergic rhinoconjunctivitis despite use of symptom-relieving medication. (Source: Journal of Allergy and Clinical Immunology)

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Inhibitory checkpoint receptors control CD8+ resident memory T cells to prevent skin allergy

The present study confirms the crucial role of epidermal CD8+ Trm for the recurrences of allergic contact dermatitis and highlights the contribution of immune checkpoint receptors on CD8+ Trm to prevent eczema flares upon allergen exposure. (Source: Journal of Allergy and Clinical Immunology)

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Anaphylaxis After Vaccination Reported To The Vaccine Adverse Event Reporting System, 1990 –2016

Of persons with anaphylaxis (a potentially life-threatening condition) reported after vaccination, 49% had no history of hypersensitivity. Vaccine providers should be prepared to respond immediately to anaphylaxis occurring in any anyone who receives a vaccine. (Source: Journal of Allergy and Clinical Immunology)

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A monoallelic activating mutation in RAC2 resulting in a combined immunodeficiency

A heterozygous gain-of-function mutation in RAC2 is associated with an autosomal dominant combined immunodeficiency. (Source: Journal of Allergy and Clinical Immunology)

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Complexities in analyzing human basophil responses to auto-antibodies to IgE or Fc εRI

(Source: Journal of Allergy and Clinical Immunology)

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Prevalence of Eosinophilic Colitis and the Diagnoses Associated with Colonic Eosinophilia

Pediatric eosinophilic colitis (EC) is a rare disease with a prevalence of ∼1/63,000 individuals, and at our tertiary care pediatric medical center, only 2% of patients with the ICD-9/10 code for EC likely have the disease. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2RrnH7X

Association between rhinovirus species and nasopharyngeal microbiota in infants with severe bronchiolitis

Among 774 infants with severe bronchiolitis, rhinovirus species related to distinct nasopharyngeal microbiota. Infants with rhinovirus-A were more likely to have Haemophilus-dominant microbiota profile, while those with rhinovirus-C were more likely to have Moraxella-dominant profile. (Source: Journal of Allergy and Clinical Immunology)

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IL-21 promotes allergic airway inflammation by driving apoptosis of FoxP3+ regulatory T cells

IL-21 indirectly sustains proinflammatory effector T cell responses by sensitizing FoxP3+ Tregs to caspase-dependent apoptosis. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2RspQQJ

IFN- γ and CD25 drive distinct pathologic features during hemophagocytic lymphohistiocytosis

Inflammatory activation of CD8+ T cells can, when left unchecked, drive severe immunopathology. Hyperstimulation of CD8+ T cells through a broad set of triggering signals can precipitate hemophagocytic lymphohistiocytosis (HLH), a life-threatening systemic inflammatory disorder. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2CovngK

Cytokine-induced endogenous production of prostaglandin D2 is essential for human group 2 innate lymphoid cell activation

Group 2 innate lymphoid cells (ILC2s) play a key role in the initiation and maintenance of type 2 immune responses. The prostaglandin (PG) D2 –chemoattractant receptor–homologous molecule expressed on TH2 cells (CRTH2) receptor axis potently induces cytokine production and ILC2 migration. (Source: Journal of Allergy and Clinical Immunology)

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Adult-Onset Food Allergies Increasing, Confusing

Forty-eight percent of the adult population with a convincing food allergy reported developing at least one as an adult (they may have had others as a child) (Source: WebMD Health)

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Gut microbes from healthy infants block milk allergy development in mice

(NIH/National Institute of Allergy and Infectious Diseases) New research suggests that the gut microbiome may help prevent the development of cow's milk allergy. Scientists at the University of Chicago found that gut microbes from healthy human infant donors transplanted into mice protected animals exposed to milk from experiencing allergic reactions, while gut microbes transplanted from infants allergic to milk did not. The work, described online today in Nature Medicine, was supported in part by NIAID. (Source: EurekAlert! - Medicine and Health)

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Adult-Onset Food Allergies Increasing, Confusing

Forty-eight percent of the adult population with a convincing food allergy reported developing at least one as an adult (they may have had others as a child) (Source: WebMD Health)

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Adult-Onset Food Allergies Increasing, Confusing

Forty-eight percent of the adult population with a convincing food allergy reported developing at least one as an adult (they may have had others as a child) (Source: WebMD Health)

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Gut microbes from healthy infants block milk allergy development in mice

(NIH/National Institute of Allergy and Infectious Diseases) New research suggests that the gut microbiome may help prevent the development of cow's milk allergy. Scientists at the University of Chicago found that gut microbes from healthy human infant donors transplanted into mice protected animals exposed to milk from experiencing allergic reactions, while gut microbes transplanted from infants allergic to milk did not. The work, described online today in Nature Medicine, was supported in part by NIAID. (Source: EurekAlert! - Medicine and Health)

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Adult-Onset Food Allergies Increasing, Confusing

Forty-eight percent of the adult population with a convincing food allergy reported developing at least one as an adult (they may have had others as a child) (Source: WebMD Health)

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2stftgM

Gut microbes from healthy infants block milk allergy development in mice

(NIH/National Institute of Allergy and Infectious Diseases) New research suggests that the gut microbiome may help prevent the development of cow's milk allergy. Scientists at the University of Chicago found that gut microbes from healthy human infant donors transplanted into mice protected animals exposed to milk from experiencing allergic reactions, while gut microbes transplanted from infants allergic to milk did not. The work, described online today in Nature Medicine, was supported in part by NIAID. (Source: EurekAlert! - Medicine and Health)

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Daily outpatient intravenous antibiotic therapy for the management of pediatric periorbital cellulitis, a retrospective case series of sixty‐six patients

Abstract

Objective

To evaluate whether outpatient treatment of periorbital cellulitis with daily administration of intravenous antibiotics and physician evaluation is an effective and safe alternative to admission.

Design

A retrospective chart review study of pediatric patients treated on an outpatient basis for periorbital cellulitis at a tertiary children's hospital between 2013‐2015 was performed. Children were assessed day by a pediatrician to monitor for resolution of symptoms or complications.

Setting

The Montreal Children's hospital, a tertiary care center.

Participants

Children diagnosed with an uncomplicated periorbital cellulitis secondary to an acute sinusitis or upper respiratory tract infection.

Main outcome measures

The number of days of intravenous antibiotics, complications or need for subsequent admission. Complications were defined as formation of an abscess or phlegmon confirmed on computerized tomography scan, worsening or recurrent persistent cellulitis, failure to improve on intravenous antibiotics, and intracranial complications.

Results

Sixty‐six children with a diagnosis of uncomplicated periorbital cellulitis secondary to sinusitis who received intravenous antibiotics via medical day hospital and who fit the inclusion criteria were identified. The mean duration of intravenous antibiotic therapy was 4.1 days. All children received ceftriaxone, with one patient also receiving cefuroxime. Two of 66 patients developed complications; one patient required admission for failure to improve/subperiosteal phlegmon and later underwent functional endoscopic sinus surgery, and one patient developed an eyelid abscess that did not require admission. No patients developed severe neurological or visual deficits.

Conclusions

Outpatient intravenous therapy with daily reassessment by a physician may be a safe alternative to admission in select cases of periorbital cellulitis without systemic signs of illness.

This article is protected by copyright. All rights reserved.

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Using CAR-T Therapies In Leukemia & Lymphoma

Frederick Locke, MD Program Co-Leader, Immunology Moffitt Cancer Center Discusses Using CAR-T Therapies In Leukemia & Lymphoma. At The 60th ASH Annual Meeting on Dec 1, 2018. Author: obr Added: 01/12/2019 (Source: Oncology Tube)

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Using CAR-T Therapies In Leukemia & Lymphoma

Frederick Locke, MD Program Co-Leader, Immunology Moffitt Cancer Center Discusses Using CAR-T Therapies In Leukemia & Lymphoma. At The 60th ASH Annual Meeting on Dec 1, 2018. Author: obr Added: 01/12/2019 (Source: Oncology Tube)

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Daily outpatient intravenous antibiotic therapy for the management of pediatric periorbital cellulitis, a retrospective case series of sixty‐six patients

Abstract

Objective

To evaluate whether outpatient treatment of periorbital cellulitis with daily administration of intravenous antibiotics and physician evaluation is an effective and safe alternative to admission.

Design

A retrospective chart review study of pediatric patients treated on an outpatient basis for periorbital cellulitis at a tertiary children's hospital between 2013‐2015 was performed. Children were assessed day by a pediatrician to monitor for resolution of symptoms or complications.

Setting

The Montreal Children's hospital, a tertiary care center.

Participants

Children diagnosed with an uncomplicated periorbital cellulitis secondary to an acute sinusitis or upper respiratory tract infection.

Main outcome measures

The number of days of intravenous antibiotics, complications or need for subsequent admission. Complications were defined as formation of an abscess or phlegmon confirmed on computerized tomography scan, worsening or recurrent persistent cellulitis, failure to improve on intravenous antibiotics, and intracranial complications.

Results

Sixty‐six children with a diagnosis of uncomplicated periorbital cellulitis secondary to sinusitis who received intravenous antibiotics via medical day hospital and who fit the inclusion criteria were identified. The mean duration of intravenous antibiotic therapy was 4.1 days. All children received ceftriaxone, with one patient also receiving cefuroxime. Two of 66 patients developed complications; one patient required admission for failure to improve/subperiosteal phlegmon and later underwent functional endoscopic sinus surgery, and one patient developed an eyelid abscess that did not require admission. No patients developed severe neurological or visual deficits.

Conclusions

Outpatient intravenous therapy with daily reassessment by a physician may be a safe alternative to admission in select cases of periorbital cellulitis without systemic signs of illness.

This article is protected by copyright. All rights reserved.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SPsyww

Ultrasound-assisted definition of inferior border of the trapezius muscle in lower trapezius island flap reconstruction

Abstract

Utilization of lower trapezius island flap (LTIF) provides an alternative in reconstruction of the select defects in head and neck region. When muscle bulk is needed under the skin paddle, it may be important to know the exact location of the inferior edge of the trapezius muscle (TM) in order to design the skin paddle accordingly. Due to the anatomic variations seen especially in the origin of trapezius muscle, there are no reliable surface landmarks to define the inferior edge of TM. We present a simple ultrasound-assisted technique of identifying the inferior border of TM preoperatively.

Level of Evidence: Level V, diagnostic study.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2FxEBKZ

Ultrasound-assisted definition of inferior border of the trapezius muscle in lower trapezius island flap reconstruction

Abstract

Utilization of lower trapezius island flap (LTIF) provides an alternative in reconstruction of the select defects in head and neck region. When muscle bulk is needed under the skin paddle, it may be important to know the exact location of the inferior edge of the trapezius muscle (TM) in order to design the skin paddle accordingly. Due to the anatomic variations seen especially in the origin of trapezius muscle, there are no reliable surface landmarks to define the inferior edge of TM. We present a simple ultrasound-assisted technique of identifying the inferior border of TM preoperatively.

Level of Evidence: Level V, diagnostic study.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2FxEBKZ

Ultrasound-assisted definition of inferior border of the trapezius muscle in lower trapezius island flap reconstruction

Abstract

Utilization of lower trapezius island flap (LTIF) provides an alternative in reconstruction of the select defects in head and neck region. When muscle bulk is needed under the skin paddle, it may be important to know the exact location of the inferior edge of the trapezius muscle (TM) in order to design the skin paddle accordingly. Due to the anatomic variations seen especially in the origin of trapezius muscle, there are no reliable surface landmarks to define the inferior edge of TM. We present a simple ultrasound-assisted technique of identifying the inferior border of TM preoperatively.

Level of Evidence: Level V, diagnostic study.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2FxEBKZ

Ultrasound-assisted definition of inferior border of the trapezius muscle in lower trapezius island flap reconstruction

Abstract

Utilization of lower trapezius island flap (LTIF) provides an alternative in reconstruction of the select defects in head and neck region. When muscle bulk is needed under the skin paddle, it may be important to know the exact location of the inferior edge of the trapezius muscle (TM) in order to design the skin paddle accordingly. Due to the anatomic variations seen especially in the origin of trapezius muscle, there are no reliable surface landmarks to define the inferior edge of TM. We present a simple ultrasound-assisted technique of identifying the inferior border of TM preoperatively.

Level of Evidence: Level V, diagnostic study.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2FxEBKZ

Fossil pollen and spores as a tool for reconstructing ancient solar-ultraviolet irradiance received by plants: an assessment of prospects and challenges using proxy-system modelling

Photochem. Photobiol. Sci., 2019, Accepted Manuscript
DOI: 10.1039/C8PP00490K, Perspective

Alistair W.R. Seddon, Daniela Festi, T. Matthew Robson, Boris Zimmermann
Ultraviolet-B radiation (UV-B, 280-315 nm) constitutes less than 1% of the total solar radiation that reaches the Earth's surface but has a disproportional impact on biological and ecological processes from...
The content of this RSS Feed (c) The Royal Society of Chemistry

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://rsc.li/2VUyDK6

Fossil pollen and spores as a tool for reconstructing ancient solar-ultraviolet irradiance received by plants: an assessment of prospects and challenges using proxy-system modelling

Photochem. Photobiol. Sci., 2019, Accepted Manuscript
DOI: 10.1039/C8PP00490K, Perspective

Alistair W.R. Seddon, Daniela Festi, T. Matthew Robson, Boris Zimmermann
Ultraviolet-B radiation (UV-B, 280-315 nm) constitutes less than 1% of the total solar radiation that reaches the Earth's surface but has a disproportional impact on biological and ecological processes from...
The content of this RSS Feed (c) The Royal Society of Chemistry

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://rsc.li/2VUyDK6

Radiomics in Oncological PET/CT: a Methodological Overview

Abstract

Radiomics is a medical imaging analysis approach based on computer-vision. Metabolic radiomics in particular analyses the spatial distribution patterns of molecular metabolism on PET images. Measuring intratumoral heterogeneity via image is one of the main targets of radiomics research, and it aims to build a image-based model for better patient management. The workflow of radiomics using texture analysis follows these steps: 1) imaging (image acquisition and reconstruction); 2) preprocessing (segmentation & quantization); 3) quantification (texture matrix design & texture feature extraction); and 4) analysis (statistics and/or machine learning). The parameters or conditions at each of these steps are effect on the results. In statistical testing or modeling, problems such as multiple comparisons, dependence on other variables, and high dimensionality of small sample size data should be considered. Standardization of methodology and harmonization of image quality are one of the most important challenges with radiomics methodology. Even though there are current issues in radiomics methodology, it is expected that radiomics will be clinically useful in personalized medicine for oncology.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Rxgzap

Clinical Personal Connectomics Using Hybrid PET/MRI

Abstract

Brain connectivity can now be studied with topological analysis using persistent homology. It overcame the arbitrariness of thresholding to make binary graphs for comparison between disease and normal control groups. Resting-state fMRI can yield personal interregional brain connectivity based on perfusion signal on MRI on individual subject bases and FDG PET produces the topography of glucose metabolism. Assuming metabolism perfusion coupling and disregarding the slight difference of representing time of metabolism (before image acquisition) and representing time of perfusion (during image acquisition), topography of brain metabolism on FDG PET and topologically analyzed brain connectivity on resting-state fMRI might be related to yield personal connectomics of individual subjects and even individual patients. The work of association of FDG PET/resting-state fMRI is yet to be warranted; however, the statistics behind the group comparison of connectivity on FDG PET or resting-state MRI was already developed. Before going further into the connectomics construction using directed weighted brain graphs of FDG PET or resting-state fMRI, I detailed in this review the plausibility of using hybrid PET/MRI to enable the interpretation of personal connectomics which can lead to the clinical use of brain connectivity in the near future.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2CiEuQe

Radiomics in Oncological PET/CT: a Methodological Overview

Abstract

Radiomics is a medical imaging analysis approach based on computer-vision. Metabolic radiomics in particular analyses the spatial distribution patterns of molecular metabolism on PET images. Measuring intratumoral heterogeneity via image is one of the main targets of radiomics research, and it aims to build a image-based model for better patient management. The workflow of radiomics using texture analysis follows these steps: 1) imaging (image acquisition and reconstruction); 2) preprocessing (segmentation & quantization); 3) quantification (texture matrix design & texture feature extraction); and 4) analysis (statistics and/or machine learning). The parameters or conditions at each of these steps are effect on the results. In statistical testing or modeling, problems such as multiple comparisons, dependence on other variables, and high dimensionality of small sample size data should be considered. Standardization of methodology and harmonization of image quality are one of the most important challenges with radiomics methodology. Even though there are current issues in radiomics methodology, it is expected that radiomics will be clinically useful in personalized medicine for oncology.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Rxgzap

Clinical Personal Connectomics Using Hybrid PET/MRI

Abstract

Brain connectivity can now be studied with topological analysis using persistent homology. It overcame the arbitrariness of thresholding to make binary graphs for comparison between disease and normal control groups. Resting-state fMRI can yield personal interregional brain connectivity based on perfusion signal on MRI on individual subject bases and FDG PET produces the topography of glucose metabolism. Assuming metabolism perfusion coupling and disregarding the slight difference of representing time of metabolism (before image acquisition) and representing time of perfusion (during image acquisition), topography of brain metabolism on FDG PET and topologically analyzed brain connectivity on resting-state fMRI might be related to yield personal connectomics of individual subjects and even individual patients. The work of association of FDG PET/resting-state fMRI is yet to be warranted; however, the statistics behind the group comparison of connectivity on FDG PET or resting-state MRI was already developed. Before going further into the connectomics construction using directed weighted brain graphs of FDG PET or resting-state fMRI, I detailed in this review the plausibility of using hybrid PET/MRI to enable the interpretation of personal connectomics which can lead to the clinical use of brain connectivity in the near future.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2CiEuQe

A specific synbiotic-containing amino acid-based formula in dietary management of cow’s milk allergy: a randomized controlled trial

Abstract

Background

Here we report follow-up data from a double-blind, randomized, controlled multicenter trial, which investigated fecal microbiota changes with a new amino acid-based formula (AAF) including synbiotics in infants with non-immunoglobulin E (IgE)-mediated cow's milk allergy (CMA).

Methods

Subjects were randomized to receive test product (AAF including fructo-oligosaccharides and Bifidobacterium breve M-16V) or control product (AAF) for 8 weeks, after which infants could continue study product until 26 weeks. Fecal percentages of bifidobacteria and Eubacterium rectale/Clostridium coccoides group (ER/CC) were assessed at 0, 8, 12, and 26 weeks. Additional endpoints included stool markers of gut immune status, clinical symptoms, and safety assessments including adverse events and medication use.

Results

The trial included 35 test subjects, 36 controls, and 51 in the healthy reference group. Study product was continued by 86% and 92% of test and control subjects between week 8–12, and by 71% and 80%, respectively until week 26. At week 26 median percentages of bifidobacteria were significantly higher in test than control [47.0% vs. 11.8% (p < 0.001)], whereas percentages of ER/CC were significantly lower [(13.7% vs. 23.6% (p = 0.003)]. Safety parameters were similar between groups. Interestingly use of dermatological medication and reported ear infections were lower in test versus control, p = 0.019 and 0.011, respectively. Baseline clinical symptoms and stool markers were mild (but persistent) and low, respectively. Symptoms reduced towards lowest score in both groups.

Conclusion

Beneficial effects of this AAF including specific synbiotics on microbiota composition were observed over 26 weeks, and shown suitable for dietary management of infants with non-IgE-mediated CMA.

Trial Registration NTR3979

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2RvPe8r

A specific synbiotic-containing amino acid-based formula in dietary management of cow’s milk allergy: a randomized controlled trial

Abstract

Background

Here we report follow-up data from a double-blind, randomized, controlled multicenter trial, which investigated fecal microbiota changes with a new amino acid-based formula (AAF) including synbiotics in infants with non-immunoglobulin E (IgE)-mediated cow's milk allergy (CMA).

Methods

Subjects were randomized to receive test product (AAF including fructo-oligosaccharides and Bifidobacterium breve M-16V) or control product (AAF) for 8 weeks, after which infants could continue study product until 26 weeks. Fecal percentages of bifidobacteria and Eubacterium rectale/Clostridium coccoides group (ER/CC) were assessed at 0, 8, 12, and 26 weeks. Additional endpoints included stool markers of gut immune status, clinical symptoms, and safety assessments including adverse events and medication use.

Results

The trial included 35 test subjects, 36 controls, and 51 in the healthy reference group. Study product was continued by 86% and 92% of test and control subjects between week 8–12, and by 71% and 80%, respectively until week 26. At week 26 median percentages of bifidobacteria were significantly higher in test than control [47.0% vs. 11.8% (p < 0.001)], whereas percentages of ER/CC were significantly lower [(13.7% vs. 23.6% (p = 0.003)]. Safety parameters were similar between groups. Interestingly use of dermatological medication and reported ear infections were lower in test versus control, p = 0.019 and 0.011, respectively. Baseline clinical symptoms and stool markers were mild (but persistent) and low, respectively. Symptoms reduced towards lowest score in both groups.

Conclusion

Beneficial effects of this AAF including specific synbiotics on microbiota composition were observed over 26 weeks, and shown suitable for dietary management of infants with non-IgE-mediated CMA.

Trial Registration NTR3979

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2RvPe8r

A EAACI Drug Allergy Interest Group survey on how European allergy specialists deal with β‐lactam allergy

Abstract

An accurate diagnosis of β‐lactam (BL) allergy can reduce patient morbidity and mortality. Our aim is to investigate the availability of BL reagents, their use, and test procedures in different parts of Europe, as well as any differences in the diagnostic workups for evaluating subjects with BL hypersensitivity. A survey was emailed to all members of the EAACI Drug Allergy Interest Group (DAIG) between February‐April 2016, the questionnaire was meant to study the management of suspected BL hypersensitivity.The questionnaire was emailed to 82 DAIG centres and answered by 57. Amoxicillin alone or combined to clavulanic acid the most commonly involved BL except in the Danish centre, where penicillin V was the most frequently suspected BL. All centres performed an allergy workup in subjects with histories of hypersensitivity to BL; 53 centres (93%) followed DAIG guidelines, 2 national guidelines, and 2 local guidelines. However, there were deviations from DAIG recommendations concerning allergy tests, especially drug provocation tests. A significant heterogeneity exists in current practice not only among countries, but also among centres within the same country. This suggests the need to re‐evaluate, update, and standardise protocols on the management of patients with suspected BL allergy.

This article is protected by copyright. All rights reserved.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2VLQHFY

A EAACI Drug Allergy Interest Group survey on how European allergy specialists deal with β‐lactam allergy

Abstract

An accurate diagnosis of β‐lactam (BL) allergy can reduce patient morbidity and mortality. Our aim is to investigate the availability of BL reagents, their use, and test procedures in different parts of Europe, as well as any differences in the diagnostic workups for evaluating subjects with BL hypersensitivity. A survey was emailed to all members of the EAACI Drug Allergy Interest Group (DAIG) between February‐April 2016, the questionnaire was meant to study the management of suspected BL hypersensitivity.The questionnaire was emailed to 82 DAIG centres and answered by 57. Amoxicillin alone or combined to clavulanic acid the most commonly involved BL except in the Danish centre, where penicillin V was the most frequently suspected BL. All centres performed an allergy workup in subjects with histories of hypersensitivity to BL; 53 centres (93%) followed DAIG guidelines, 2 national guidelines, and 2 local guidelines. However, there were deviations from DAIG recommendations concerning allergy tests, especially drug provocation tests. A significant heterogeneity exists in current practice not only among countries, but also among centres within the same country. This suggests the need to re‐evaluate, update, and standardise protocols on the management of patients with suspected BL allergy.

This article is protected by copyright. All rights reserved.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2VLQHFY

Sociological and Medical Factors Influence Outcomes in Facial Trauma Malpractice

Medical error within the United States carries significant economic and safety costs, both of which manifest in a large number of malpractice suits filed each year. The aim of this study is to characterize the various sociological and medical factors that influence malpractice suits occurring from cases of facial trauma.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2D9dqVp

The Inferior Alveolar Nerve: To Graft or Not to Graft in Ablative Mandibular Resection?

To determine contemporary surgical decision-making processes regarding the use of a nerve graft with ablative mandibular resection, and to identify utilization barriers amongst head and neck surgeons.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2TPDoCG

A 15-Year Review of Trainee Contributions to the Journal of Oral and Maxillofacial Surgery

The purpose of this study was to quantify trainee contributions to the Journal of Oral and Maxillofacial Surgery (JOMS).

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2TNAiiA

Surgical Management Of Mandibular Subcondylar Fractures Under Local Anaesthesia - A Proposed Protocol

The optimal treatment for adult mandibular condylar fractures (MCFs) has largely shifted in favour of open reduction and rigid internal fixation (ORIF). However a sizeable portion of these injuries are still being treated closed based on old literature, convenience, "acceptable" results, and lesser associated morbidity.Most MCFs with multiple associated facial trauma are appropriately treated under general anaesthesia(GA). However, some selected isolated MCFs or ones with minimal associated mandibular or low mid-facial fractures can be treated optimally under local anaesthesia(LA) following a protocol presented here, thus expediting and simplifying their management.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2D9nZHZ

Which clinicopathologic factors affect the prognosis of gingival squamous cell carcinoma: a population analysis of 4,345 cases

The purpose of this study was to present the characteristics and survival outcomes of primary gingival SCC.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2TJTaPw

Maxillomandibular Advancement for Severe Obstructive Sleep Apnea is a Highly Skeletally Stable Long-term Procedure.

Evaluate the long-term clinically significant cephalometric skeletal stability with maxillomandibular advancement (MMA) for obstructive sleep apnea (OSA).

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2D8tRRx

Comparison of piezosurgery and conventional osteotomy post rhinoplasty morbidities: A double-blind randomized controlled trial

Several approaches have been introduced to reduce soft tissue injury during rhinoplasty. Piezoelectric ultrasonic could be used to perform bone surgeries more precise and avoid soft tissue perforation.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2TSeH8N

Higher Ki67 index, nodal involvement and invasive growth were high risk factors for worse prognosis in conventional mammary analogue secretory carcinoma

The prognostic factors of salivary (mammary analogue) secretory carcinoma (SC) are unclear because of the rarity of the tumor. Here we presented the largest case series to investigate the prognosis-related clinicopathological factors in conventional SC.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Daqhqo

Changes in condylar position after mandibular reconstruction with condylar head preservation by computed tomography

Condylar position may change after mandibular reconstruction using free fibula flap. The present study evaluated changes in condylar position using computed tomography (CT) after mandibular reconstruction with condylar head preservation.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2D9JzMl

Removal of Impacted Supernumerary Teeth Using a Dynamic Surgical Navigation System: A Case Report

Removal of impacted supernumerary teeth can present a unique set of challenges to the dentoalveolar surgeon. Complications associated with these challenges have been well documented in the literature. The use of dynamically guided surgical navigation technology for the removal of impacted supernumerary teeth has the potential to mitigate these challenges and improve clinical outcomes. Though not a currently FDA- approved indication, the use of dynamic surgical navigation systems for the removal of impacted supernumerary teeth will be elucidated in this case report.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2TNiNPl

Pre-Operative Assessment Of Obstructive Sleep Apnea In The Ambulatory Anesthesia Patient: A Survey Of Oral And Maxillofacial Surgery Providers

Oral and maxillofacial surgeons (OMS) often treat patients with both diagnosed and undiagnosed obstructive sleep apnea (OSA). Patients with OSA are at significant risk for peri- and post-operative complications after receiving intravenous sedation, general anesthesia, or post-operative opiate analgesia. The purpose of this study was to determine whether OMS providers are screening patients for peri- and post-operative risks related to OSA prior to office-based ambulatory anesthesia.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Daq72g

Sociological and Medical Factors Influence Outcomes in Facial Trauma Malpractice

Medical error within the United States carries significant economic and safety costs, both of which manifest in a large number of malpractice suits filed each year. The aim of this study is to characterize the various sociological and medical factors that influence malpractice suits occurring from cases of facial trauma.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2D9dqVp

The Inferior Alveolar Nerve: To Graft or Not to Graft in Ablative Mandibular Resection?

To determine contemporary surgical decision-making processes regarding the use of a nerve graft with ablative mandibular resection, and to identify utilization barriers amongst head and neck surgeons.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2TPDoCG

Touch Imprint Cytology – Can it serve as an alternate to Frozen Section, in Intraoperative assessment of cervical metastasis in Oral Squamous Cell Carcinoma?

To assess the diagnostic accuracy of touch imprint cytology (TIC) as compared to frozen section analysis(FS) as an Intraoperative diagnostic tool to assess nodal metastasis in oral squamous cell carcinoma(OSCC).

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Day47u

A 15-Year Review of Trainee Contributions to the Journal of Oral and Maxillofacial Surgery

The purpose of this study was to quantify trainee contributions to the Journal of Oral and Maxillofacial Surgery (JOMS).

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2TNAiiA

Surgical Management Of Mandibular Subcondylar Fractures Under Local Anaesthesia - A Proposed Protocol

The optimal treatment for adult mandibular condylar fractures (MCFs) has largely shifted in favour of open reduction and rigid internal fixation (ORIF). However a sizeable portion of these injuries are still being treated closed based on old literature, convenience, "acceptable" results, and lesser associated morbidity.Most MCFs with multiple associated facial trauma are appropriately treated under general anaesthesia(GA). However, some selected isolated MCFs or ones with minimal associated mandibular or low mid-facial fractures can be treated optimally under local anaesthesia(LA) following a protocol presented here, thus expediting and simplifying their management.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2D9nZHZ

Which clinicopathologic factors affect the prognosis of gingival squamous cell carcinoma: a population analysis of 4,345 cases

The purpose of this study was to present the characteristics and survival outcomes of primary gingival SCC.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2TJTaPw

Maxillomandibular Advancement for Severe Obstructive Sleep Apnea is a Highly Skeletally Stable Long-term Procedure.

Evaluate the long-term clinically significant cephalometric skeletal stability with maxillomandibular advancement (MMA) for obstructive sleep apnea (OSA).

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2D8tRRx

Sociological and Medical Factors Influence Outcomes in Facial Trauma Malpractice

Medical error within the United States carries significant economic and safety costs, both of which manifest in a large number of malpractice suits filed each year. The aim of this study is to characterize the various sociological and medical factors that influence malpractice suits occurring from cases of facial trauma.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2D9dqVp

The Inferior Alveolar Nerve: To Graft or Not to Graft in Ablative Mandibular Resection?

To determine contemporary surgical decision-making processes regarding the use of a nerve graft with ablative mandibular resection, and to identify utilization barriers amongst head and neck surgeons.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2TPDoCG

Touch Imprint Cytology – Can it serve as an alternate to Frozen Section, in Intraoperative assessment of cervical metastasis in Oral Squamous Cell Carcinoma?

To assess the diagnostic accuracy of touch imprint cytology (TIC) as compared to frozen section analysis(FS) as an Intraoperative diagnostic tool to assess nodal metastasis in oral squamous cell carcinoma(OSCC).

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Day47u

A 15-Year Review of Trainee Contributions to the Journal of Oral and Maxillofacial Surgery

The purpose of this study was to quantify trainee contributions to the Journal of Oral and Maxillofacial Surgery (JOMS).

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2TNAiiA

Surgical Management Of Mandibular Subcondylar Fractures Under Local Anaesthesia - A Proposed Protocol

The optimal treatment for adult mandibular condylar fractures (MCFs) has largely shifted in favour of open reduction and rigid internal fixation (ORIF). However a sizeable portion of these injuries are still being treated closed based on old literature, convenience, "acceptable" results, and lesser associated morbidity.Most MCFs with multiple associated facial trauma are appropriately treated under general anaesthesia(GA). However, some selected isolated MCFs or ones with minimal associated mandibular or low mid-facial fractures can be treated optimally under local anaesthesia(LA) following a protocol presented here, thus expediting and simplifying their management.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2D9nZHZ

Which clinicopathologic factors affect the prognosis of gingival squamous cell carcinoma: a population analysis of 4,345 cases

The purpose of this study was to present the characteristics and survival outcomes of primary gingival SCC.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2TJTaPw

Maxillomandibular Advancement for Severe Obstructive Sleep Apnea is a Highly Skeletally Stable Long-term Procedure.

Evaluate the long-term clinically significant cephalometric skeletal stability with maxillomandibular advancement (MMA) for obstructive sleep apnea (OSA).

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2D8tRRx

Comparison of piezosurgery and conventional osteotomy post rhinoplasty morbidities: A double-blind randomized controlled trial

Several approaches have been introduced to reduce soft tissue injury during rhinoplasty. Piezoelectric ultrasonic could be used to perform bone surgeries more precise and avoid soft tissue perforation.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2TSeH8N

Higher Ki67 index, nodal involvement and invasive growth were high risk factors for worse prognosis in conventional mammary analogue secretory carcinoma

The prognostic factors of salivary (mammary analogue) secretory carcinoma (SC) are unclear because of the rarity of the tumor. Here we presented the largest case series to investigate the prognosis-related clinicopathological factors in conventional SC.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Daqhqo

Titanium Lag Screw Versus Miniplate Fixation In The Treatment Of Anterior Mandibular Fractures

The use of plates for open reduction and internal fixation of mandibular fractures has become a widely accepted method in the past three decades. However, the anterior mandible is well suited to lag screw fixation owing to the thickness of its bony cortices. Hence, the purpose of the present study was to comparatively evaluate clinical outcomes of fixation using lag screws and miniplates in anterior mandibular fractures.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2TNiST9

Changes in condylar position after mandibular reconstruction with condylar head preservation by computed tomography

Condylar position may change after mandibular reconstruction using free fibula flap. The present study evaluated changes in condylar position using computed tomography (CT) after mandibular reconstruction with condylar head preservation.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2D9JzMl

Removal of Impacted Supernumerary Teeth Using a Dynamic Surgical Navigation System: A Case Report

Removal of impacted supernumerary teeth can present a unique set of challenges to the dentoalveolar surgeon. Complications associated with these challenges have been well documented in the literature. The use of dynamically guided surgical navigation technology for the removal of impacted supernumerary teeth has the potential to mitigate these challenges and improve clinical outcomes. Though not a currently FDA- approved indication, the use of dynamic surgical navigation systems for the removal of impacted supernumerary teeth will be elucidated in this case report.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2TNiNPl

Pre-Operative Assessment Of Obstructive Sleep Apnea In The Ambulatory Anesthesia Patient: A Survey Of Oral And Maxillofacial Surgery Providers

Oral and maxillofacial surgeons (OMS) often treat patients with both diagnosed and undiagnosed obstructive sleep apnea (OSA). Patients with OSA are at significant risk for peri- and post-operative complications after receiving intravenous sedation, general anesthesia, or post-operative opiate analgesia. The purpose of this study was to determine whether OMS providers are screening patients for peri- and post-operative risks related to OSA prior to office-based ambulatory anesthesia.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Daq72g

Sociological and Medical Factors Influence Outcomes in Facial Trauma Malpractice

Medical error within the United States carries significant economic and safety costs, both of which manifest in a large number of malpractice suits filed each year. The aim of this study is to characterize the various sociological and medical factors that influence malpractice suits occurring from cases of facial trauma.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2D9dqVp

The Inferior Alveolar Nerve: To Graft or Not to Graft in Ablative Mandibular Resection?

To determine contemporary surgical decision-making processes regarding the use of a nerve graft with ablative mandibular resection, and to identify utilization barriers amongst head and neck surgeons.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2TPDoCG

Touch Imprint Cytology – Can it serve as an alternate to Frozen Section, in Intraoperative assessment of cervical metastasis in Oral Squamous Cell Carcinoma?

To assess the diagnostic accuracy of touch imprint cytology (TIC) as compared to frozen section analysis(FS) as an Intraoperative diagnostic tool to assess nodal metastasis in oral squamous cell carcinoma(OSCC).

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Day47u

A 15-Year Review of Trainee Contributions to the Journal of Oral and Maxillofacial Surgery

The purpose of this study was to quantify trainee contributions to the Journal of Oral and Maxillofacial Surgery (JOMS).

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2TNAiiA

Surgical Management Of Mandibular Subcondylar Fractures Under Local Anaesthesia - A Proposed Protocol

The optimal treatment for adult mandibular condylar fractures (MCFs) has largely shifted in favour of open reduction and rigid internal fixation (ORIF). However a sizeable portion of these injuries are still being treated closed based on old literature, convenience, "acceptable" results, and lesser associated morbidity.Most MCFs with multiple associated facial trauma are appropriately treated under general anaesthesia(GA). However, some selected isolated MCFs or ones with minimal associated mandibular or low mid-facial fractures can be treated optimally under local anaesthesia(LA) following a protocol presented here, thus expediting and simplifying their management.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2D9nZHZ

Which clinicopathologic factors affect the prognosis of gingival squamous cell carcinoma: a population analysis of 4,345 cases

The purpose of this study was to present the characteristics and survival outcomes of primary gingival SCC.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2TJTaPw

Maxillomandibular Advancement for Severe Obstructive Sleep Apnea is a Highly Skeletally Stable Long-term Procedure.

Evaluate the long-term clinically significant cephalometric skeletal stability with maxillomandibular advancement (MMA) for obstructive sleep apnea (OSA).

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2D8tRRx

Functional recovery after bilateral extended autologous latissimus dorsi breast reconstruction: A prospective observational study

The impact of unilateral extended autologous latissimus dorsi (EALD) flap harvest and axillary surgery on shoulder function has been well described, but the impact of bilateral EALD flap harvest not clearly defined. Nor is it clear whether reconstructions should be synchronous, or staged.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2CnZXaF

The ideal intercostal space for internal mammary vessel exposure during total rib-sparing microvascular breast reconstruction: A critical evaluation

Total rib-preserving free flap breast reconstruction (RP-FFBR) using internal mammary vessel (IMV) recipients usually involves vessel exposure in the 2nd or 3rd intercostal spaces (ICS). Although the 3rd is more commonly used no direct comparisons between the two have hitherto been performed.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2RuMMic

What is Optimal Wound Management to Prevent Infection in Non-Hand Mammalian Bite Injuries? A Systematic Review

Mammalian bites account for 1% of all Emergency Department (ED) visits in the United Kingdom, with infection rates varying from 2% to 20%.1,2 Mammalian bites on the hand, where tendons and joints are more superficial, are more prone to infection and should be considered separately.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Cl2aU4

Evaluation of the eyebrow position after external Müller's muscle tucking—a new technique for ptosis repair

Eyebrow descent commonly occurs after ptosis repair or blepharoplasty surgery. The procedures used to correct acquired blepharoptosis are primarily classified into four groups. These procedures target the levator aponeurosis, Müller's muscle, both the aponeurosis and Müller's muscle, or the frontalis muscle. In this study, we used a new technique called external Müller's muscle tucking (EMMT) on 51 patients (94 eyelids), which targets the Müller's muscle for involutional blepharoptosis. The patients were assessed by means of a comparative analysis using pre- and postoperative digital photographs.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2RwIjM3

Intranodal Lymphangiography with Indocyanine Green: Application in Lymph Node Transfer and Beyond

Diagnostic imaging of truncal lymphatics is a diverse field with several modalities available. The growing popularity of vascularized lymph node transfer (VLNT) for the treatment of lymphedema has brought the topic into focus of plastic reconstructive surgeons worldwide. During this procedure, it is physiologically advantageous to perform lymph node efferent lymphatico-lymphatic anastomosis (ELLA) by including efferent lymphatic vessels in the flap while avoiding excess soft tissue 3. However, in practice it is difficult to identify these vessels.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2CoifID

Endoscopic Retrieval of Retracted Flexor Tendons: An Atraumatic Technique

The repair of retracted flexor tendons is a challenging problem for hand surgeons. The tendon stump should be handled in an atraumatic manner because any microtrauma to the sheath and tendon can lead to poor functional outcomes.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2RrKq3D

Flexor tendon retrieval in Zone 2 using the push-pull technique

Flexor zone 2 tendon injuries often present with tendon retraction into the palm. This is particularly the case when the injury occurs with the hand clenched over a sharp object such as a knife. To minimize tendon sheath and annular pulley injury, multiple techniques have been described for flexor tendon retrieval using dental wire,1 paediatric feeding tubes2,3 and skin hooks.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2CqTbAG

First look: A Mixed Methods Study Exploring Women's Initial Experiences Of Their Appearance After Mastectomy And/Or Breast Reconstruction

Increasing numbers of women are undergoing appearance-altering surgery for the treatment and/or prevention of breast cancer. However, women's experiences of seeing the results of their breast surgery for the first time, and the support available to them, are currently omitted from the research literature. This study aimed to explore women's initial experiences of seeing their appearance after mastectomy and/or breast reconstruction.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2RtK5NV

SELECTIVE NON-OPERATIVE MANAGEMENT FOR PENETRATING EXTREMITY TRAUMA (SNOM-PET)

We appreciate the comments by Dickson and colleagues in their letter to the editor on our published article.1 We agree with them that non-operative management is a pragmatic approach for penetrating trauma and our paper is the first documented attempt to apply this approach to a UK trauma population. It is inevitable and appropriate that conservative management of trauma is scrutinized as it is counter to most current plastic surgical doctrine, though conservative management of other types of trauma is commonplace.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2CoaYZc

Letter to the Editor regarding – Selective non-operative management for penetrating extremity trauma: A paradigm shift in management

We read with great interest the recently published cohort study by Hettiaratchy et al1 comparing penetrating extremity injury examination results to operative findings. The increasing rate of crime involving a knife or sharp object2 is of concern to all trauma surgeons, and a great pressure to develop safe and effective clinical pathways for penetrating trauma. We agree with the authors that more pragmatic methods may be appropriate to treat these injuries, but question the author's assertion that their data has shown selective non-operative management to be a safe alternative to surgical exploration.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2RvCI8M

RE: Not a plastic surgeon's best friend: Dog bites an increasing burden on UK Plastic Surgery services

We believe there is an under-estimation on the burden and cost toward the NHS regarding dog bites. It is estimated that £9.5 million per year is spent on managing dog bites.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2CoV7cY

A Comparison of Patient Reported Outcome Measures in Patients who received both DIEP Flap and PAP Flap Breast Reconstructions

Breast reconstruction should be routinely offered to patients undergoing mastectomy surgery for breast cancer.1 Post-operative recovery-time, the patient's occupation, hobbies and lifestyle must be considered when determining the most appropriate reconstruction technique for individual patients. Generally, patients prefer autologous breast reconstruction over implant-based methods for cosmetic and psychological reasons.2 The Deep Inferior Epigastric Perforator (DIEP) flap is considered the gold-standard technique in free-flap autologous breast reconstruction however the Profunda Artery Perforator (PAP) flap is increasing in popularity amongst selected patients.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2RrKmAV

Letter to editor: Surgical-site infection following lymph node excision indicates susceptibility for lymphedema: A retrospective cohort study of malignant melanoma patients

Following the reading of the original article "Surgical-site infection following lymph node excision indicates susceptibility for lymphedema: A retrospective cohort study of malignant melanoma patients", the authors reviewed the literature for the discussed therapeutic value of complete lymph node dissection (CLND), the major complications and the current treatment for lymphedema. The authors also share their experience and protocol for CLND, and treating lymphedema using lymph node flap transfer and multiple lymphatic-venous anastomoses.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2CjPLjo

Preconditioning and postoperative hyperbaric oxygen therapy to reduce skin flap erosion after osmidrosis surgery

Osmidrosis surgery is still recognized as one of the best ways to treat body odor,1 especially the liposuction assisted curettage due to the relatively small incision that does not leave any scars, which, nevertheless, may still cause many complications. One of the most common complications is the erosion of the skin flap, where the necrosis of the flap incision edge is about 4%.2 Therefore, physicians who perform such surgeries often observe varying degrees of manifestations, some of which are relatively common superficial erosions (Figure 1) and some of which are proportionately deep erosions.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Rv6R8k

Functional recovery after bilateral extended autologous latissimus dorsi breast reconstruction: A prospective observational study

The impact of unilateral extended autologous latissimus dorsi (EALD) flap harvest and axillary surgery on shoulder function has been well described, but the impact of bilateral EALD flap harvest not clearly defined. Nor is it clear whether reconstructions should be synchronous, or staged.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2CnZXaF

The ideal intercostal space for internal mammary vessel exposure during total rib-sparing microvascular breast reconstruction: A critical evaluation

Total rib-preserving free flap breast reconstruction (RP-FFBR) using internal mammary vessel (IMV) recipients usually involves vessel exposure in the 2nd or 3rd intercostal spaces (ICS). Although the 3rd is more commonly used no direct comparisons between the two have hitherto been performed.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2RuMMic

What is Optimal Wound Management to Prevent Infection in Non-Hand Mammalian Bite Injuries? A Systematic Review

Mammalian bites account for 1% of all Emergency Department (ED) visits in the United Kingdom, with infection rates varying from 2% to 20%.1,2 Mammalian bites on the hand, where tendons and joints are more superficial, are more prone to infection and should be considered separately.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Cl2aU4

Evaluation of the eyebrow position after external Müller's muscle tucking—a new technique for ptosis repair

Eyebrow descent commonly occurs after ptosis repair or blepharoplasty surgery. The procedures used to correct acquired blepharoptosis are primarily classified into four groups. These procedures target the levator aponeurosis, Müller's muscle, both the aponeurosis and Müller's muscle, or the frontalis muscle. In this study, we used a new technique called external Müller's muscle tucking (EMMT) on 51 patients (94 eyelids), which targets the Müller's muscle for involutional blepharoptosis. The patients were assessed by means of a comparative analysis using pre- and postoperative digital photographs.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2RwIjM3

Intranodal Lymphangiography with Indocyanine Green: Application in Lymph Node Transfer and Beyond

Diagnostic imaging of truncal lymphatics is a diverse field with several modalities available. The growing popularity of vascularized lymph node transfer (VLNT) for the treatment of lymphedema has brought the topic into focus of plastic reconstructive surgeons worldwide. During this procedure, it is physiologically advantageous to perform lymph node efferent lymphatico-lymphatic anastomosis (ELLA) by including efferent lymphatic vessels in the flap while avoiding excess soft tissue 3. However, in practice it is difficult to identify these vessels.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2CoifID

Endoscopic Retrieval of Retracted Flexor Tendons: An Atraumatic Technique

The repair of retracted flexor tendons is a challenging problem for hand surgeons. The tendon stump should be handled in an atraumatic manner because any microtrauma to the sheath and tendon can lead to poor functional outcomes.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2RrKq3D

Flexor tendon retrieval in Zone 2 using the push-pull technique

Flexor zone 2 tendon injuries often present with tendon retraction into the palm. This is particularly the case when the injury occurs with the hand clenched over a sharp object such as a knife. To minimize tendon sheath and annular pulley injury, multiple techniques have been described for flexor tendon retrieval using dental wire,1 paediatric feeding tubes2,3 and skin hooks.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2CqTbAG

First look: A Mixed Methods Study Exploring Women's Initial Experiences Of Their Appearance After Mastectomy And/Or Breast Reconstruction

Increasing numbers of women are undergoing appearance-altering surgery for the treatment and/or prevention of breast cancer. However, women's experiences of seeing the results of their breast surgery for the first time, and the support available to them, are currently omitted from the research literature. This study aimed to explore women's initial experiences of seeing their appearance after mastectomy and/or breast reconstruction.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2RtK5NV

SELECTIVE NON-OPERATIVE MANAGEMENT FOR PENETRATING EXTREMITY TRAUMA (SNOM-PET)

We appreciate the comments by Dickson and colleagues in their letter to the editor on our published article.1 We agree with them that non-operative management is a pragmatic approach for penetrating trauma and our paper is the first documented attempt to apply this approach to a UK trauma population. It is inevitable and appropriate that conservative management of trauma is scrutinized as it is counter to most current plastic surgical doctrine, though conservative management of other types of trauma is commonplace.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2CoaYZc

Letter to the Editor regarding – Selective non-operative management for penetrating extremity trauma: A paradigm shift in management

We read with great interest the recently published cohort study by Hettiaratchy et al1 comparing penetrating extremity injury examination results to operative findings. The increasing rate of crime involving a knife or sharp object2 is of concern to all trauma surgeons, and a great pressure to develop safe and effective clinical pathways for penetrating trauma. We agree with the authors that more pragmatic methods may be appropriate to treat these injuries, but question the author's assertion that their data has shown selective non-operative management to be a safe alternative to surgical exploration.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2RvCI8M

RE: Not a plastic surgeon's best friend: Dog bites an increasing burden on UK Plastic Surgery services

We believe there is an under-estimation on the burden and cost toward the NHS regarding dog bites. It is estimated that £9.5 million per year is spent on managing dog bites.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2CoV7cY

A Comparison of Patient Reported Outcome Measures in Patients who received both DIEP Flap and PAP Flap Breast Reconstructions

Breast reconstruction should be routinely offered to patients undergoing mastectomy surgery for breast cancer.1 Post-operative recovery-time, the patient's occupation, hobbies and lifestyle must be considered when determining the most appropriate reconstruction technique for individual patients. Generally, patients prefer autologous breast reconstruction over implant-based methods for cosmetic and psychological reasons.2 The Deep Inferior Epigastric Perforator (DIEP) flap is considered the gold-standard technique in free-flap autologous breast reconstruction however the Profunda Artery Perforator (PAP) flap is increasing in popularity amongst selected patients.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2RrKmAV

Letter to editor: Surgical-site infection following lymph node excision indicates susceptibility for lymphedema: A retrospective cohort study of malignant melanoma patients

Following the reading of the original article "Surgical-site infection following lymph node excision indicates susceptibility for lymphedema: A retrospective cohort study of malignant melanoma patients", the authors reviewed the literature for the discussed therapeutic value of complete lymph node dissection (CLND), the major complications and the current treatment for lymphedema. The authors also share their experience and protocol for CLND, and treating lymphedema using lymph node flap transfer and multiple lymphatic-venous anastomoses.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2CjPLjo

Preconditioning and postoperative hyperbaric oxygen therapy to reduce skin flap erosion after osmidrosis surgery

Osmidrosis surgery is still recognized as one of the best ways to treat body odor,1 especially the liposuction assisted curettage due to the relatively small incision that does not leave any scars, which, nevertheless, may still cause many complications. One of the most common complications is the erosion of the skin flap, where the necrosis of the flap incision edge is about 4%.2 Therefore, physicians who perform such surgeries often observe varying degrees of manifestations, some of which are relatively common superficial erosions (Figure 1) and some of which are proportionately deep erosions.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Rv6R8k

Association between rhinovirus species and nasopharyngeal microbiota in infants with severe bronchiolitis

Among 774 infants with severe bronchiolitis, rhinovirus species related to distinct nasopharyngeal microbiota. Infants with rhinovirus-A were more likely to have Haemophilus-dominant microbiota profile, while those with rhinovirus-C were more likely to have Moraxella-dominant profile.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2FyEcb5

Anaphylaxis After Vaccination Reported To The Vaccine Adverse Event Reporting System, 1990–2016

Of persons with anaphylaxis (a potentially life-threatening condition) reported after vaccination, 49% had no history of hypersensitivity. Vaccine providers should be prepared to respond immediately to anaphylaxis occurring in any anyone who receives a vaccine.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Fsh8vl

Prevalence of Eosinophilic Colitis and the Diagnoses Associated with Colonic Eosinophilia

Pediatric eosinophilic colitis (EC) is a rare disease with a prevalence of ∼1/63,000 individuals, and at our tertiary care pediatric medical center, only 2% of patients with the ICD-9/10 code for EC likely have the disease.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2FxTDjO

Sublingual immunotherapy with the SQ tree SLIT-tablet is highly effective and well tolerated: results from a randomized, double-blind, placebo-controlled phase III trial

The trial demonstrated efficacy and safety of the SQ tree SLIT-tablet compared to placebo in adolescents and adults with moderate-severe birch pollen induced allergic rhinoconjunctivitis despite use of symptom-relieving medication.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2FsM2E7

Early life undernutrition reprograms CD4+ T-cell glycolysis and epigenetics to facilitate asthma

Nutrition is central to early life development. The maternal diet remodels cell-intrinsic glucose metabolism and epigenetic status within offspring T cells, resulting in exacerbated Th2 differentiation and susceptibility to asthma.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2FwjoRH

Inhibitory checkpoint receptors control CD8+ resident memory T cells to prevent skin allergy

The present study confirms the crucial role of epidermal CD8+ Trm for the recurrences of allergic contact dermatitis and highlights the contribution of immune checkpoint receptors on CD8+ Trm to prevent eczema flares upon allergen exposure.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2FseHsO

Complexities in analyzing human basophil responses to auto-antibodies to IgE or FcεRI

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Fz4k5M

A monoallelic activating mutation in RAC2 resulting in a combined immunodeficiency

A heterozygous gain-of-function mutation in RAC2 is associated with an autosomal dominant combined immunodeficiency.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Fsq6cm

Early decreases in blood eosinophil levels with reslizumab

Reslizumab, an anti-IL5 add-on therapy, demonstrated clinical effectiveness in patients with severe eosinophilic asthma in 52-week Phase 3 studies. Eosinophil reductions were observed within 2–3 days of initiation and were sustained for 52 weeks.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Fz41YG

IL-21 promotes allergic airway inflammation by driving apoptosis of FoxP3+ regulatory T cells

IL-21 indirectly sustains proinflammatory effector T cell responses by sensitizing FoxP3+ Tregs to caspase-dependent apoptosis.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2FrK2vF

Association between rhinovirus species and nasopharyngeal microbiota in infants with severe bronchiolitis

Among 774 infants with severe bronchiolitis, rhinovirus species related to distinct nasopharyngeal microbiota. Infants with rhinovirus-A were more likely to have Haemophilus-dominant microbiota profile, while those with rhinovirus-C were more likely to have Moraxella-dominant profile.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2FyEcb5

Anaphylaxis After Vaccination Reported To The Vaccine Adverse Event Reporting System, 1990–2016

Of persons with anaphylaxis (a potentially life-threatening condition) reported after vaccination, 49% had no history of hypersensitivity. Vaccine providers should be prepared to respond immediately to anaphylaxis occurring in any anyone who receives a vaccine.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Fsh8vl

Prevalence of Eosinophilic Colitis and the Diagnoses Associated with Colonic Eosinophilia

Pediatric eosinophilic colitis (EC) is a rare disease with a prevalence of ∼1/63,000 individuals, and at our tertiary care pediatric medical center, only 2% of patients with the ICD-9/10 code for EC likely have the disease.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2FxTDjO

Sublingual immunotherapy with the SQ tree SLIT-tablet is highly effective and well tolerated: results from a randomized, double-blind, placebo-controlled phase III trial

The trial demonstrated efficacy and safety of the SQ tree SLIT-tablet compared to placebo in adolescents and adults with moderate-severe birch pollen induced allergic rhinoconjunctivitis despite use of symptom-relieving medication.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2FsM2E7

Early life undernutrition reprograms CD4+ T-cell glycolysis and epigenetics to facilitate asthma

Nutrition is central to early life development. The maternal diet remodels cell-intrinsic glucose metabolism and epigenetic status within offspring T cells, resulting in exacerbated Th2 differentiation and susceptibility to asthma.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2FwjoRH

Inhibitory checkpoint receptors control CD8+ resident memory T cells to prevent skin allergy

The present study confirms the crucial role of epidermal CD8+ Trm for the recurrences of allergic contact dermatitis and highlights the contribution of immune checkpoint receptors on CD8+ Trm to prevent eczema flares upon allergen exposure.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2FseHsO

Complexities in analyzing human basophil responses to auto-antibodies to IgE or FcεRI

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Fz4k5M

A monoallelic activating mutation in RAC2 resulting in a combined immunodeficiency

A heterozygous gain-of-function mutation in RAC2 is associated with an autosomal dominant combined immunodeficiency.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Fsq6cm

Early decreases in blood eosinophil levels with reslizumab

Reslizumab, an anti-IL5 add-on therapy, demonstrated clinical effectiveness in patients with severe eosinophilic asthma in 52-week Phase 3 studies. Eosinophil reductions were observed within 2–3 days of initiation and were sustained for 52 weeks.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Fz41YG

IL-21 promotes allergic airway inflammation by driving apoptosis of FoxP3+ regulatory T cells

IL-21 indirectly sustains proinflammatory effector T cell responses by sensitizing FoxP3+ Tregs to caspase-dependent apoptosis.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2FrK2vF

Medical News Today: Healthy babies' gut bacteria prevent common food allergy

Transplanting intestinal bacteria from healthy human babies into germ-free mice prevented the animals from having allergic reactions to cow's milk. (Source: Health News from Medical News Today)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Fr2PHI

Medical News Today: Healthy babies' gut bacteria prevent common food allergy

Transplanting intestinal bacteria from healthy human babies into germ-free mice prevented the animals from having allergic reactions to cow's milk. (Source: Health News from Medical News Today)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Fr2PHI

New app gives throat cancer patients their voice back

Source: www.straitstimes.com Author: staff Vlastimil Gular's life took an unwelcome turn a year ago: minor surgery on his vocal cords revealed […]

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2FxMNuL

New app gives throat cancer patients their voice back

Source: www.straitstimes.com Author: staff Vlastimil Gular's life took an unwelcome turn a year ago: minor surgery on his vocal cords revealed […]

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2FxMNuL

Clinical and Immunological Long-term Follow-up of Patients With Pemphigus Included in the " RITUXIMAB 3 " Trial

Condition:   Autoimmune Diseases Interventions:   Drug: Rituximab;   Drug: corticosteroids'therapy Sponsor:   University Hospital, Rouen Not yet recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2AJjXV2

Study to Assess Safety and Activity of Combination Therapy of VRC07-523LS and Vorinostat on HIV-infected Persons

Condition:   HIV-1 Infection Interventions:   Biological: VRC07-523LS;   Drug: Vorinostat (VOR) Sponsors:   University of North Carolina, Chapel Hill;   National Institute of Allergy and Infectious Diseases (NIAID) Recruiting (Source: ClinicalTrials.gov)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2AO7VK3

Exploring Disease Immunogenicity and the Immunological Effects of Hypomethylating Agents in Acute Myeloid Leukemia

Condition:   Acute Myeloid Leukemia Intervention:   Genetic: Immunogenic profile Sponsor:   Istituto Scientifico Romagnolo per lo Studio e la cura dei Tumori Not yet recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SUUpeu

Study to Assess Safety and Activity of Combination Therapy of VRC07-523LS and Vorinostat on HIV-infected Persons

Condition:   HIV-1 Infection Interventions:   Biological: VRC07-523LS;   Drug: Vorinostat (VOR) Sponsors:   University of North Carolina, Chapel Hill;   National Institute of Allergy and Infectious Diseases (NIAID) Recruiting (Source: ClinicalTrials.gov)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2AO7VK3

Exploring Disease Immunogenicity and the Immunological Effects of Hypomethylating Agents in Acute Myeloid Leukemia

Condition:   Acute Myeloid Leukemia Intervention:   Genetic: Immunogenic profile Sponsor:   Istituto Scientifico Romagnolo per lo Studio e la cura dei Tumori Not yet recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SUUpeu

Clinical and Immunological Long-term Follow-up of Patients With Pemphigus Included in the " RITUXIMAB 3 " Trial

Condition:   Autoimmune Diseases Interventions:   Drug: Rituximab;   Drug: corticosteroids'therapy Sponsor:   University Hospital, Rouen Not yet recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2AJjXV2

Atopic Dermatitis | Medscape Atopic Dermatitis | Medscape

Atopic dermatitis is a chronic inflammatory skin disease with a complex etiology that encompasses immunologic responses, susceptibility genes, environmental triggers, and compromised skin-barrier function. (Source: Medscape Today Headlines)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2MbTMuu

Medical News Today: Healthy babies' gut bacteria prevent common food allergy

Transplanting intestinal bacteria from healthy human babies into germ-free mice prevented the animals from having allergic reactions to cow's milk. (Source: Health News from Medical News Today)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Fr2PHI

Clinical trial testing fecal microbiota transplant for recurrent diarrheal disease begins

(NIH/National Institute of Allergy and Infectious Diseases) A research consortium recently began enrolling patients in a clinical trial examining whether fecal microbiota transplantation (FMT) by enema--putting stool from a healthy donor in the colon of a recipient--is safe and can prevent recurrent Clostridium difficile-associated disease (CDAD), a potentially life-threatening diarrheal illness. Investigators aim to enroll 162 volunteer participants 18 years or older who have had two or more episodes of CDAD within the previous six months. (Source: EurekAlert! - Infectious and Emerging Diseases)

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Atopic Dermatitis | Medscape Atopic Dermatitis | Medscape

Atopic dermatitis is a chronic inflammatory skin disease with a complex etiology that encompasses immunologic responses, susceptibility genes, environmental triggers, and compromised skin-barrier function. (Source: Medscape Today Headlines)

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Medical News Today: Healthy babies' gut bacteria prevent common food allergy

Transplanting intestinal bacteria from healthy human babies into germ-free mice prevented the animals from having allergic reactions to cow's milk. (Source: Health News from Medical News Today)

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Clinical trial testing fecal microbiota transplant for recurrent diarrheal disease begins

(NIH/National Institute of Allergy and Infectious Diseases) A research consortium recently began enrolling patients in a clinical trial examining whether fecal microbiota transplantation (FMT) by enema--putting stool from a healthy donor in the colon of a recipient--is safe and can prevent recurrent Clostridium difficile-associated disease (CDAD), a potentially life-threatening diarrheal illness. Investigators aim to enroll 162 volunteer participants 18 years or older who have had two or more episodes of CDAD within the previous six months. (Source: EurekAlert! - Infectious and Emerging Diseases)

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The Impact of CMV Coinfection on Immunological and Clinical Outcomes in African Children Born to HIV-infected Mothers

Date: Thursday, 02 14, 2019; Speaker: Dr. Sarah Rowland-Jones, Professor, Immunology, University of Oxford, Medical Sciences Division; Building: NCI at Frederick, Building 426 (Source: NIH Calendar of Events)

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Immunology Interest Group (IIG) Seminar Series - Sara Cherry (UPenn) - “Applying Functional Genomics to Explore Virus-Host Interactions and Beyond” - Sara Cherry (Penn)

Date: Wednesday, 01 16, 2019; Speaker: Sara Cherry, Professor of Microbiology& Immunology, University of Pennsylvanya; Building: Building 10 (Clinical Center); Lipsett Auditorium; Videocast Event (Source: NIH Calendar of Events)

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The Impact of CMV Coinfection on Immunological and Clinical Outcomes in African Children Born to HIV-infected Mothers

Date: Thursday, 02 14, 2019; Speaker: Dr. Sarah Rowland-Jones, Professor, Immunology, University of Oxford, Medical Sciences Division; Building: NCI at Frederick, Building 426 (Source: NIH Calendar of Events)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

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Immunology Interest Group (IIG) Seminar Series - Sara Cherry (UPenn) - “Applying Functional Genomics to Explore Virus-Host Interactions and Beyond” - Sara Cherry (Penn)

Date: Wednesday, 01 16, 2019; Speaker: Sara Cherry, Professor of Microbiology& Immunology, University of Pennsylvanya; Building: Building 10 (Clinical Center); Lipsett Auditorium; Videocast Event (Source: NIH Calendar of Events)

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New app gives throat cancer patients their voice back

Source: www.straitstimes.com Author: staff Vlastimil Gular's life took an unwelcome turn a year ago: minor surgery on his vocal cords revealed […]

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New app gives throat cancer patients their voice back

Source: www.straitstimes.com Author: staff Vlastimil Gular's life took an unwelcome turn a year ago: minor surgery on his vocal cords revealed […]

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Atopic Dermatitis | Medscape Atopic Dermatitis | Medscape

Atopic dermatitis is a chronic inflammatory skin disease with a complex etiology that encompasses immunologic responses, susceptibility genes, environmental triggers, and compromised skin-barrier function. (Source: Medscape Today Headlines)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2MbTMuu

Clinical trial testing fecal microbiota transplant for recurrent diarrheal disease begins

(NIH/National Institute of Allergy and Infectious Diseases) A research consortium recently began enrolling patients in a clinical trial examining whether fecal microbiota transplantation (FMT) by enema--putting stool from a healthy donor in the colon of a recipient--is safe and can prevent recurrent Clostridium difficile-associated disease (CDAD), a potentially life-threatening diarrheal illness. Investigators aim to enroll 162 volunteer participants 18 years or older who have had two or more episodes of CDAD within the previous six months. (Source: EurekAlert! - Infectious and Emerging Diseases)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2sqXaIU

Atopic Dermatitis | Medscape Atopic Dermatitis | Medscape

Atopic dermatitis is a chronic inflammatory skin disease with a complex etiology that encompasses immunologic responses, susceptibility genes, environmental triggers, and compromised skin-barrier function. (Source: Medscape Today Headlines)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2MbTMuu

Clinical trial testing fecal microbiota transplant for recurrent diarrheal disease begins

(NIH/National Institute of Allergy and Infectious Diseases) A research consortium recently began enrolling patients in a clinical trial examining whether fecal microbiota transplantation (FMT) by enema--putting stool from a healthy donor in the colon of a recipient--is safe and can prevent recurrent Clostridium difficile-associated disease (CDAD), a potentially life-threatening diarrheal illness. Investigators aim to enroll 162 volunteer participants 18 years or older who have had two or more episodes of CDAD within the previous six months. (Source: EurekAlert! - Infectious and Emerging Diseases)

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2018 Reviewer Thank You

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2018 Reviewer Thank You

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Flap Reconstruction after Groin and Medial Thigh Sarcoma Resection Reduces the Risk of Lower-Extremity Lymphedema

Extensive resection is an effective treatment for sarcomas in the groin and medial thigh region; however, various complications may develop postoperatively.1,2 Infection, lymphorrhea, and lymphedema frequently develop in the groin/medial thigh because of the important lymphatic pathways from the lower extremities. Prolonged lymphorrhea and lymphatic cysts are causes of chronic lower-extremity lymphedema.1 Symptoms become further exacerbated because of repeated cellulitis and movement limitations.

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