Prevention of Lyme disease in dogs in North America depends on effective vaccination against infection by the tick vector-born spirochete Borrelia burgdorferi. Most vaccines effectively prevent spirochete transmi... (Source: BMC Veterinary Research)
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Τρίτη 16 Οκτωβρίου 2018
Characterization of recombinant OspA in two different Borrelia vaccines with respect to immunological response and its relationship to functional parameters
Beyond nutrients, health effects of entomophagy: a systematic review
Nutrition&Food Science, Ahead of Print. Purpose Edible insects have emerged as a promising inexpensive option to address malnutrition among vulnerable groups in the world. However, it is not clear whether including insects in diets can improve health outcomes. This paper aimed to investigate the impact of edible insect consumption on human health. Design/methodology/approach A search was conducted in PubMed Central, BioMed Central, Plosone, Cochrane, Google Scholar, Google Search and bibliographies for all human studies on the impact of edible insect consumption on human health published from January 1990 to April 2018. Findings Twelve studies met the inclusion criteria. Consumption of cereals fortified with edible insects improved iron status and growth in infants and led to the devel...
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Characterization of recombinant OspA in two different Borrelia vaccines with respect to immunological response and its relationship to functional parameters
Prevention of Lyme disease in dogs in North America depends on effective vaccination against infection by the tick vector-born spirochete Borrelia burgdorferi. Most vaccines effectively prevent spirochete transmi... (Source: BMC Veterinary Research)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2CoPk9d
Beyond nutrients, health effects of entomophagy: a systematic review
Nutrition&Food Science, Ahead of Print. Purpose Edible insects have emerged as a promising inexpensive option to address malnutrition among vulnerable groups in the world. However, it is not clear whether including insects in diets can improve health outcomes. This paper aimed to investigate the impact of edible insect consumption on human health. Design/methodology/approach A search was conducted in PubMed Central, BioMed Central, Plosone, Cochrane, Google Scholar, Google Search and bibliographies for all human studies on the impact of edible insect consumption on human health published from January 1990 to April 2018. Findings Twelve studies met the inclusion criteria. Consumption of cereals fortified with edible insects improved iron status and growth in infants and led to the devel...
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The relationship between health literacy and quality of life: a systematic review and meta-analysis
Low health literacy often has an association with poor health outcomes such as low levels of self-efficacy, increased mortality, poor health status and reduced quality of life (QOL). The aim of the study was t...
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The relationship between health literacy and quality of life: a systematic review and meta-analysis
Low health literacy often has an association with poor health outcomes such as low levels of self-efficacy, increased mortality, poor health status and reduced quality of life (QOL). The aim of the study was t...
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Correction to: Cytokine release kinetics of concentrated growth factors in different scaffolds
Legend of fig. 1a and b was reversed in the original version of this article.
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Correction to: Cytokine release kinetics of concentrated growth factors in different scaffolds
Legend of fig. 1a and b was reversed in the original version of this article.
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Intensive Care Practice in the Cancer Patient Population: Special Considerations and Challenges
Abstract
Purpose of Review
As the modern era of cancer treatment improves survival for patients, intensive care units (ICUs) play an increasing role in their management to support patients during cancer therapy. This review seeks to summarise some important changes and persisting challenges in the care of this complex patient group.
Recent Findings
Technological advances and improvements in overall cancer treatment have challenged historical approaches to suitability for admission and provision of ICU support. In particular, old paradigms (such as not admitting hematological malignancy patients to the ICU for mechanical ventilation) no longer apply in the modern era. Improved peri-operative care and advances in surgical techniques rely on the availability of the ICU for post-operative support, particularly after increasingly complex surgical procedures are embarked on with curative intent.
Summary
Intensive care is an integral part of the multidisciplinary care required for cancer patients. Challenges, including ethical aspects and difficulties with risk stratification, remain.
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Intensive Care Practice in the Cancer Patient Population: Special Considerations and Challenges
Abstract
Purpose of Review
As the modern era of cancer treatment improves survival for patients, intensive care units (ICUs) play an increasing role in their management to support patients during cancer therapy. This review seeks to summarise some important changes and persisting challenges in the care of this complex patient group.
Recent Findings
Technological advances and improvements in overall cancer treatment have challenged historical approaches to suitability for admission and provision of ICU support. In particular, old paradigms (such as not admitting hematological malignancy patients to the ICU for mechanical ventilation) no longer apply in the modern era. Improved peri-operative care and advances in surgical techniques rely on the availability of the ICU for post-operative support, particularly after increasingly complex surgical procedures are embarked on with curative intent.
Summary
Intensive care is an integral part of the multidisciplinary care required for cancer patients. Challenges, including ethical aspects and difficulties with risk stratification, remain.
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Plasma tryptase elevation during aspirin-induced reactions in aspirin-exacerbated respiratory disease (AERD)
Plasma tryptase elevation during aspirin-induced respiratory reactions occurs in 50% of reactions despite CysLT1R antagonist prophylaxis and identifies lung function decline and extra-respiratory symptoms in aspirin-exacerbated respiratory disease (AERD). (Source: Journal of Allergy and Clinical Immunology)
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RhoH deficiency induces psoriasis-like chronic dermatitis by promoting TH17 cell polarization
RhoH could be a risk factor for exacerbation of psoriasis by inhibiting effector function of TH17 cells. (Source: Journal of Allergy and Clinical Immunology)
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Engulfment of mast cell secretory granules upon skin inflammation boosts dendritic cell migration and priming efficiency
Dudeck et al. demonstrate that MC granules are engulfed by DCs upon skin inflammation and actively shuttled to LNs. MC granule uptake boosts DC activation and T cell priming efficiency, thereby enhancing the inflammatory response. (Source: Journal of Allergy and Clinical Immunology)
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Immunosuppression for immunodeficiency- getting smarter
(Source: Journal of Allergy and Clinical Immunology)
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Plasma tryptase elevation during aspirin-induced reactions in aspirin-exacerbated respiratory disease (AERD)
Plasma tryptase elevation during aspirin-induced respiratory reactions occurs in 50% of reactions despite CysLT1R antagonist prophylaxis and identifies lung function decline and extra-respiratory symptoms in aspirin-exacerbated respiratory disease (AERD). (Source: Journal of Allergy and Clinical Immunology)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OxI8P5
RhoH deficiency induces psoriasis-like chronic dermatitis by promoting TH17 cell polarization
RhoH could be a risk factor for exacerbation of psoriasis by inhibiting effector function of TH17 cells. (Source: Journal of Allergy and Clinical Immunology)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OwBZ5V
Engulfment of mast cell secretory granules upon skin inflammation boosts dendritic cell migration and priming efficiency
Dudeck et al. demonstrate that MC granules are engulfed by DCs upon skin inflammation and actively shuttled to LNs. MC granule uptake boosts DC activation and T cell priming efficiency, thereby enhancing the inflammatory response. (Source: Journal of Allergy and Clinical Immunology)
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Immunosuppression for immunodeficiency- getting smarter
(Source: Journal of Allergy and Clinical Immunology)
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Dimethyl fumarate as a first- vs second-line therapy in MS: Focus on B cells
Conclusions DMF is associated with increased transitional and IL10+ and TGFβ+ regulatory B cells and a shift toward a more anti-inflammatory immune profile. Cell activation with reduced costimulatory capacity may induce immune hyporesponsiveness. Carryover effects of preceding therapies in 2nd-line patients and the stage of disease influence the immune profile of the patients and the immunomodulatory effects of DMF. (Source: Neurology Neuroimmunology and Neuroinflammation)
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Allergic myocardial infarction: Type I Kounis syndrome following blue crab consumption
. (Source: Acta Clinica Belgica)
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Dimethyl fumarate as a first- vs second-line therapy in MS: Focus on B cells
Conclusions DMF is associated with increased transitional and IL10+ and TGFβ+ regulatory B cells and a shift toward a more anti-inflammatory immune profile. Cell activation with reduced costimulatory capacity may induce immune hyporesponsiveness. Carryover effects of preceding therapies in 2nd-line patients and the stage of disease influence the immune profile of the patients and the immunomodulatory effects of DMF. (Source: Neurology Neuroimmunology and Neuroinflammation)
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Allergic myocardial infarction: Type I Kounis syndrome following blue crab consumption
. (Source: Acta Clinica Belgica)
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Genomic mutations and proof of causation between dysplasia and squamous cell carcinoma in medicolegal cases: a useful approach or a waste of resources?
It has been suggested that oral stratified squamous epithelium may be implicated in field cancerisation.1,2 Several other studies have examined the clonal relations between dysplasia and oral squamous cell carcinoma (SCC),3,4 and it is now obvious that the relation between dysplasia at a specific site in the oral cavity, and a subsequent SCC that has arisen at the same site several years later, is a complex rather than a simple progression.5 Those of us who see patients with mucosal abnormalities often treat lesions with low-grade or high-grade dysplasia. (Source: The British Journal of Oral and Maxillofacial Surgery)
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New Light Shed on HIV-1 Reservoir Reductions After Stem Cell Transplant New Light Shed on HIV-1 Reservoir Reductions After Stem Cell Transplant
Several factors underlie a profound reduction in the HIV-1 reservoir in patients who undergo allogeneic hematopoietic stem cell transplant (allo-HSCT) for hematologic disease, researchers report.Reuters Health Information (Source: Medscape Allergy Headlines)
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Cannabis Allergy Tests Show Differing Performance Cannabis Allergy Tests Show Differing Performance
The most effective means of confirming allergy to Cannabis sativa appear to be a skin prick test and a specific immunoglobulin E (sIgE) test, according to European researchers.Reuters Health Information (Source: Medscape Allergy Headlines)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2pUPw8n
Genomic mutations and proof of causation between dysplasia and squamous cell carcinoma in medicolegal cases: a useful approach or a waste of resources?
It has been suggested that oral stratified squamous epithelium may be implicated in field cancerisation.1,2 Several other studies have examined the clonal relations between dysplasia and oral squamous cell carcinoma (SCC),3,4 and it is now obvious that the relation between dysplasia at a specific site in the oral cavity, and a subsequent SCC that has arisen at the same site several years later, is a complex rather than a simple progression.5 Those of us who see patients with mucosal abnormalities often treat lesions with low-grade or high-grade dysplasia. (Source: The British Journal of Oral and Maxillofacial Surgery)
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Adjuvants found in vaccines have led to an increase of autoimmune disease
(Natural News) Despite Big Pharma's attempts at slandering science that sheds light on the toxic reality of vaccine ingredients and their potential to cause harm, scientists around the world have continued to study vaccine adjuvants and their relationship to autoimmune disease. Immunologists from Israel have recently confirmed what past research has long suggested: Vaccine-induced disease... (Source: NaturalNews.com)
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A preliminary study on plasma concentration achieved following intrapterygomandibular space injection of dexamethasone as a route of drug delivery with lignocaine inferior alveolar nerve block –correlation of clinical effects
ConclusionIntraspace route of drug administration can be utilized to deliver dexamethasonized local anesthetics safely with predictable clinical effects in the patients requiring mandibular minor oral surgery under local anesthesia. (Source: Oral and Maxillofacial Surgery)
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Total mandibular reconstruction following diffuse sclerosing osteomyelitis
ConclusionIn the event that non-surgical options are not successful in DSO, an extended surgical therapy becomes necessary. Even if surgery results in complete resection of the mandible, a satisfactory rehabilitation can be achieved after complex reconstruction. (Source: Oral and Maxillofacial Surgery)
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Complication rate in mandibular angle fractures —one vs. two plates: a 12-year retrospective analysis
ConclusionWe found a significantly increased early complication rate in the two-plate group. Long-term complications did not differ between both groups. (Source: Oral and Maxillofacial Surgery)
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New Light Shed on HIV-1 Reservoir Reductions After Stem Cell Transplant New Light Shed on HIV-1 Reservoir Reductions After Stem Cell Transplant
Several factors underlie a profound reduction in the HIV-1 reservoir in patients who undergo allogeneic hematopoietic stem cell transplant (allo-HSCT) for hematologic disease, researchers report.Reuters Health Information (Source: Medscape Allergy Headlines)
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2NL7vrA
Adjuvants found in vaccines have led to an increase of autoimmune disease
(Natural News) Despite Big Pharma's attempts at slandering science that sheds light on the toxic reality of vaccine ingredients and their potential to cause harm, scientists around the world have continued to study vaccine adjuvants and their relationship to autoimmune disease. Immunologists from Israel have recently confirmed what past research has long suggested: Vaccine-induced disease... (Source: NaturalNews.com)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2P2xdMH
A preliminary study on plasma concentration achieved following intrapterygomandibular space injection of dexamethasone as a route of drug delivery with lignocaine inferior alveolar nerve block –correlation of clinical effects
ConclusionIntraspace route of drug administration can be utilized to deliver dexamethasonized local anesthetics safely with predictable clinical effects in the patients requiring mandibular minor oral surgery under local anesthesia. (Source: Oral and Maxillofacial Surgery)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2pU8kEU
Total mandibular reconstruction following diffuse sclerosing osteomyelitis
ConclusionIn the event that non-surgical options are not successful in DSO, an extended surgical therapy becomes necessary. Even if surgery results in complete resection of the mandible, a satisfactory rehabilitation can be achieved after complex reconstruction. (Source: Oral and Maxillofacial Surgery)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2NLiwZZ
Complication rate in mandibular angle fractures —one vs. two plates: a 12-year retrospective analysis
ConclusionWe found a significantly increased early complication rate in the two-plate group. Long-term complications did not differ between both groups. (Source: Oral and Maxillofacial Surgery)
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New Light Shed on HIV-1 Reservoir Reductions After Stem Cell Transplant New Light Shed on HIV-1 Reservoir Reductions After Stem Cell Transplant
Several factors underlie a profound reduction in the HIV-1 reservoir in patients who undergo allogeneic hematopoietic stem cell transplant (allo-HSCT) for hematologic disease, researchers report.Reuters Health Information (Source: Medscape Allergy Headlines)
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
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Response to the letter to the editor: Comment on “Streptococcus anginosus Dental Implant-Related Osteomyelitis of the Jaws: An Insidious and Calamitous Entity”
We thank Drs Nicot, Schlund, and Raoul for their observations and insightful additional comments regarding our recent article on dental implant-related suppurative osteomyelitis of the jaws (DIOMJ) from Streptococcus anginosus.1
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Cannabis Allergy Tests Show Differing Performance Cannabis Allergy Tests Show Differing Performance
The most effective means of confirming allergy to Cannabis sativa appear to be a skin prick test and a specific immunoglobulin E (sIgE) test, according to European researchers.Reuters Health Information (Source: Medscape Allergy Headlines)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2pUPw8n
Adjuvants found in vaccines have led to an increase of autoimmune disease
(Natural News) Despite Big Pharma's attempts at slandering science that sheds light on the toxic reality of vaccine ingredients and their potential to cause harm, scientists around the world have continued to study vaccine adjuvants and their relationship to autoimmune disease. Immunologists from Israel have recently confirmed what past research has long suggested: Vaccine-induced disease... (Source: NaturalNews.com)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2P2xdMH
Adjuvants found in vaccines have led to an increase of autoimmune disease
(Natural News) Despite Big Pharma's attempts at slandering science that sheds light on the toxic reality of vaccine ingredients and their potential to cause harm, scientists around the world have continued to study vaccine adjuvants and their relationship to autoimmune disease. Immunologists from Israel have recently confirmed what past research has long suggested: Vaccine-induced disease... (Source: NaturalNews.com)
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Response to the letter to the editor: Comment on “Streptococcus anginosus Dental Implant-Related Osteomyelitis of the Jaws: An Insidious and Calamitous Entity”
We thank Drs Nicot, Schlund, and Raoul for their observations and insightful additional comments regarding our recent article on dental implant-related suppurative osteomyelitis of the jaws (DIOMJ) from Streptococcus anginosus.1
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2pYdMXu
Response to the letter to the editor: Comment on “Streptococcus anginosus Dental Implant-Related Osteomyelitis of the Jaws: An Insidious and Calamitous Entity”
We thank Drs Nicot, Schlund, and Raoul for their observations and insightful additional comments regarding our recent article on dental implant-related suppurative osteomyelitis of the jaws (DIOMJ) from Streptococcus anginosus.1
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2pYdMXu
New Light Shed on HIV-1 Reservoir Reductions After Stem Cell Transplant New Light Shed on HIV-1 Reservoir Reductions After Stem Cell Transplant
Several factors underlie a profound reduction in the HIV-1 reservoir in patients who undergo allogeneic hematopoietic stem cell transplant (allo-HSCT) for hematologic disease, researchers report.Reuters Health Information (Source: Medscape Allergy Headlines)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2NL7vrA
Cannabis Allergy Tests Show Differing Performance Cannabis Allergy Tests Show Differing Performance
The most effective means of confirming allergy to Cannabis sativa appear to be a skin prick test and a specific immunoglobulin E (sIgE) test, according to European researchers.Reuters Health Information (Source: Medscape Allergy Headlines)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2pUPw8n
Response to the letter to the editor: Comment on “Streptococcus anginosus Dental Implant-Related Osteomyelitis of the Jaws: An Insidious and Calamitous Entity”
We thank Drs Nicot, Schlund, and Raoul for their observations and insightful additional comments regarding our recent article on dental implant-related suppurative osteomyelitis of the jaws (DIOMJ) from Streptococcus anginosus.1
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2pYdMXu
New Light Shed on HIV-1 Reservoir Reductions After Stem Cell Transplant New Light Shed on HIV-1 Reservoir Reductions After Stem Cell Transplant
Several factors underlie a profound reduction in the HIV-1 reservoir in patients who undergo allogeneic hematopoietic stem cell transplant (allo-HSCT) for hematologic disease, researchers report.Reuters Health Information (Source: Medscape Allergy Headlines)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2NL7vrA
Cannabis Allergy Tests Show Differing Performance Cannabis Allergy Tests Show Differing Performance
The most effective means of confirming allergy to Cannabis sativa appear to be a skin prick test and a specific immunoglobulin E (sIgE) test, according to European researchers.Reuters Health Information (Source: Medscape Allergy Headlines)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2pUPw8n
The Hexavalent CD40 Agonist HERA-CD40L Induces T-Cell–mediated Antitumor Immune Response Through Activation of Antigen-presenting Cells
CD40 ligand (TNFSF5/CD154/CD40L), a member of the tumor necrosis factor (TNF) superfamily is a key regulator of the immune system. The cognate receptor CD40 (TNFRSF5) is expressed broadly on antigen-presenting cells and many tumor types, and has emerged as an attractive target for immunologic cancer treatment. Most of the CD40 targeting drugs in clinical development are antibodies which display some disadvantages: their activity typically depends on Fcγ receptor–mediated crosslinking, and depletion of CD40-expressing immune cells by antibody-dependent cellular cytotoxicity compromises an efficient antitumor response. To overcome the inadequacies of antibodies, we have developed the hexavalent receptor agonist (HERA) Technology. HERA compounds are fusion proteins composed of 3 receptor b...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2J5f9MM
A selective window after the food-intake period favors tolerance induction in mesenteric lymph nodes
A selective window after the food-intake period favors tolerance induction in mesenteric lymph nodes, Published online: 16 October 2018; doi:10.1038/s41385-018-0095-3A selective window after the food-intake period favors tolerance induction in mesenteric lymph nodes (Source: Mucosal Immunology)
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Novel role of gastric releasing peptide-mediated signaling in the host response to influenza infection
Novel role of gastric releasing peptide-mediated signaling in the host response to influenza infection, Published online: 16 October 2018; doi:10.1038/s41385-018-0081-9Novel role of gastric releasing peptide-mediated signaling in the host response to influenza infection (Source: Mucosal Immunology)
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Immature lung TNFR2− conventional DC 2 subpopulation activates moDCs to promote cyclic di-GMP mucosal adjuvant responses in vivo
Immature lung TNFR2<sup>−</sup> conventional DC 2 subpopulation activates moDCs to promote cyclic di-GMP mucosal adjuvant responses in vivo, Published online: 16 October 2018; doi:10.1038/s41385-018-0098-0Immature lung TNFR2− conventional DC 2 subpopulation activates moDCs to promote cyclic di-GMP mucosal adjuvant responses in vivo (Source: Mucosal Immunology)
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Engulfment of mast cell secretory granules upon skin inflammation boosts dendritic cell migration and priming efficiency
Dudeck et al. demonstrate that MC granules are engulfed by DCs upon skin inflammation and actively shuttled to LNs. MC granule uptake boosts DC activation and T cell priming efficiency, thereby enhancing the inflammatory response. (Source: Journal of Allergy and Clinical Immunology)
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2J3jXSH
RhoH deficiency induces psoriasis-like chronic dermatitis by promoting TH17 cell polarization
RhoH could be a risk factor for exacerbation of psoriasis by inhibiting effector function of TH17 cells. (Source: Journal of Allergy and Clinical Immunology)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OwBZ5V
Plasma tryptase elevation during aspirin-induced reactions in aspirin-exacerbated respiratory disease (AERD)
Plasma tryptase elevation during aspirin-induced respiratory reactions occurs in 50% of reactions despite CysLT1R antagonist prophylaxis and identifies lung function decline and extra-respiratory symptoms in aspirin-exacerbated respiratory disease (AERD). (Source: Journal of Allergy and Clinical Immunology)
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Future Path Toward TB Vaccine Development: Boosting BCG or Re-educating by a New Subunit Vaccine
Nancy Gupta, Saurabh Garg, Satish Vedi, Dennis Y. Kunimoto, Rakesh Kumar, Babita Agrawal (Source: Frontiers in Immunology)
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The Hexavalent CD40 Agonist HERA-CD40L Induces T-Cell–mediated Antitumor Immune Response Through Activation of Antigen-presenting Cells
CD40 ligand (TNFSF5/CD154/CD40L), a member of the tumor necrosis factor (TNF) superfamily is a key regulator of the immune system. The cognate receptor CD40 (TNFRSF5) is expressed broadly on antigen-presenting cells and many tumor types, and has emerged as an attractive target for immunologic cancer treatment. Most of the CD40 targeting drugs in clinical development are antibodies which display some disadvantages: their activity typically depends on Fcγ receptor–mediated crosslinking, and depletion of CD40-expressing immune cells by antibody-dependent cellular cytotoxicity compromises an efficient antitumor response. To overcome the inadequacies of antibodies, we have developed the hexavalent receptor agonist (HERA) Technology. HERA compounds are fusion proteins composed of 3 receptor b...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2J5f9MM
A selective window after the food-intake period favors tolerance induction in mesenteric lymph nodes
A selective window after the food-intake period favors tolerance induction in mesenteric lymph nodes, Published online: 16 October 2018; doi:10.1038/s41385-018-0095-3A selective window after the food-intake period favors tolerance induction in mesenteric lymph nodes (Source: Mucosal Immunology)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OtJXww
Novel role of gastric releasing peptide-mediated signaling in the host response to influenza infection
Novel role of gastric releasing peptide-mediated signaling in the host response to influenza infection, Published online: 16 October 2018; doi:10.1038/s41385-018-0081-9Novel role of gastric releasing peptide-mediated signaling in the host response to influenza infection (Source: Mucosal Immunology)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2J3kSCD
Engulfment of mast cell secretory granules upon skin inflammation boosts dendritic cell migration and priming efficiency
Dudeck et al. demonstrate that MC granules are engulfed by DCs upon skin inflammation and actively shuttled to LNs. MC granule uptake boosts DC activation and T cell priming efficiency, thereby enhancing the inflammatory response. (Source: Journal of Allergy and Clinical Immunology)
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2J3jXSH
RhoH deficiency induces psoriasis-like chronic dermatitis by promoting TH17 cell polarization
RhoH could be a risk factor for exacerbation of psoriasis by inhibiting effector function of TH17 cells. (Source: Journal of Allergy and Clinical Immunology)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OwBZ5V
Immunosuppression for immunodeficiency- getting smarter
(Source: Journal of Allergy and Clinical Immunology)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2J3jEY3
Plasma tryptase elevation during aspirin-induced reactions in aspirin-exacerbated respiratory disease (AERD)
Plasma tryptase elevation during aspirin-induced respiratory reactions occurs in 50% of reactions despite CysLT1R antagonist prophylaxis and identifies lung function decline and extra-respiratory symptoms in aspirin-exacerbated respiratory disease (AERD). (Source: Journal of Allergy and Clinical Immunology)
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In vivo and in vitro assessment of the bleaching effectiveness of a brush-off patch containing 3.0% hydrogen peroxide
Abstract
Objectives
To evaluate the efficacy of a brush-off patch containing 3.0% hydrogen peroxide, which is a new over-the-counter (OTC) product for tooth whitening, and determine the optimal protocol for use.
Materials and methods
We performed an in vitro study using hydroxyapatite specimens and a clinical trial involving 140 volunteers. The brush-off patch was applied to the specimens (in vitro) or the maxillary anterior teeth (in vivo; 14 days) for 10 min twice daily (case 10 group) or 30 min once daily (case 30 group). We also included control groups in both experiments. Lightness (L*), redness (a*), and yellowness (b*) values were measured using a colorimeter. In the in vivo study, color changes were measured at baseline and 7 and 14 days after the start of patch application. The overall color change (ΔE) was statistically analyzed.
Results
In the in vitro study, the color change (ΔE*) after the experiment was significantly different between the two case groups and the control group (p < 0.001). In the in vivo study, the case groups showed color changes at both 7 and 14 days after patch application. In particular, the change in the case 30 group was significantly more prominent on day 14 than on day 7 (p < 0.05).
Conclusion
Our findings suggest that brush-off patches containing 3.0% hydrogen peroxide are effective OTC products for tooth whitening.
Clinical relevance
For best results, brush-off patches containing 3.0% hydrogen peroxide can be applied once daily for 30 min.
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Effect of adjuvant use of metformin on periodontal treatment: a systematic review and meta-analysis
Abstract
Objective
The aim of the study was to perform a systematic review of the literature regarding the adjuvant effects of metformin on the results of mechanical periodontal treatment.
Methods
First, a search on the PubMed, EMBASE, and Scopus databases was performed up to March 2018. Randomized clinical trials with at least 3 months of follow-up and using metformin associated with mechanical periodontal treatment were included in the review. As comparison group, mechanical or periodontal therapy alone or in combination with placebo. The studies should involve adults with at least 30 years of age diagnosed with chronic periodontitis. For the evaluation of the risk of bias of the articles, the Cochrane Collaboration tool was used.
Results
Studies (1912) were retrieved and 4 were included in the review. The articles are all from the same research center and used metformin in gel at concentrations of 0.5%, 1%, or 1.5%. The majority of included studies presented low risk of bias. A linear meta-analysis was conducted for probing depth and clinical attachment loss outcomes. The results showed a weighted mean difference of 2.12 mm (95% CI 1.83–2.42) and 2.29 mm (95% CI 1.72–2.86) for probing depth and clinical attachment level, respectively, favoring the group exposed to 1% adjunct metformin.
Conclusion
The adjuvant use of metformin may promote an additional benefit to the results of mechanical periodontal therapy.
Clinical significance
The metformin as an adjuvant on periodontal treatment shows potential to reduce needs of additional interventions and also reduces the inflammatory burden in patients.
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In vivo and in vitro assessment of the bleaching effectiveness of a brush-off patch containing 3.0% hydrogen peroxide
Abstract
Objectives
To evaluate the efficacy of a brush-off patch containing 3.0% hydrogen peroxide, which is a new over-the-counter (OTC) product for tooth whitening, and determine the optimal protocol for use.
Materials and methods
We performed an in vitro study using hydroxyapatite specimens and a clinical trial involving 140 volunteers. The brush-off patch was applied to the specimens (in vitro) or the maxillary anterior teeth (in vivo; 14 days) for 10 min twice daily (case 10 group) or 30 min once daily (case 30 group). We also included control groups in both experiments. Lightness (L*), redness (a*), and yellowness (b*) values were measured using a colorimeter. In the in vivo study, color changes were measured at baseline and 7 and 14 days after the start of patch application. The overall color change (ΔE) was statistically analyzed.
Results
In the in vitro study, the color change (ΔE*) after the experiment was significantly different between the two case groups and the control group (p < 0.001). In the in vivo study, the case groups showed color changes at both 7 and 14 days after patch application. In particular, the change in the case 30 group was significantly more prominent on day 14 than on day 7 (p < 0.05).
Conclusion
Our findings suggest that brush-off patches containing 3.0% hydrogen peroxide are effective OTC products for tooth whitening.
Clinical relevance
For best results, brush-off patches containing 3.0% hydrogen peroxide can be applied once daily for 30 min.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2RRvJ6G
Effect of adjuvant use of metformin on periodontal treatment: a systematic review and meta-analysis
Abstract
Objective
The aim of the study was to perform a systematic review of the literature regarding the adjuvant effects of metformin on the results of mechanical periodontal treatment.
Methods
First, a search on the PubMed, EMBASE, and Scopus databases was performed up to March 2018. Randomized clinical trials with at least 3 months of follow-up and using metformin associated with mechanical periodontal treatment were included in the review. As comparison group, mechanical or periodontal therapy alone or in combination with placebo. The studies should involve adults with at least 30 years of age diagnosed with chronic periodontitis. For the evaluation of the risk of bias of the articles, the Cochrane Collaboration tool was used.
Results
Studies (1912) were retrieved and 4 were included in the review. The articles are all from the same research center and used metformin in gel at concentrations of 0.5%, 1%, or 1.5%. The majority of included studies presented low risk of bias. A linear meta-analysis was conducted for probing depth and clinical attachment loss outcomes. The results showed a weighted mean difference of 2.12 mm (95% CI 1.83–2.42) and 2.29 mm (95% CI 1.72–2.86) for probing depth and clinical attachment level, respectively, favoring the group exposed to 1% adjunct metformin.
Conclusion
The adjuvant use of metformin may promote an additional benefit to the results of mechanical periodontal therapy.
Clinical significance
The metformin as an adjuvant on periodontal treatment shows potential to reduce needs of additional interventions and also reduces the inflammatory burden in patients.
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c-Myc Is a Major Determinant for Antitumor Activity of Aurora A Kinase Inhibitor MLN8237 in Thyroid Cancer
Thyroid, Ahead of Print.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2RUJ91Q
Persistent/Recurrent Differentiated Thyroid Cancer: Clinical and Radiological Characteristics of Persistent Disease and Clinical Recurrence Based on Computed Tomography Analysis
Thyroid, Ahead of Print.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2EruNDv
Pathological Interactions Between Mutant Thyroid Hormone Receptors and Corepressors and Their Modulation by a Thyroid Hormone Analogue with Therapeutic Potential
Thyroid, Ahead of Print.
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c-Myc Is a Major Determinant for Antitumor Activity of Aurora A Kinase Inhibitor MLN8237 in Thyroid Cancer
Thyroid, Ahead of Print.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2RUJ91Q
Response to Lenvatinib in Children with Papillary Thyroid Carcinoma
Thyroid, Ahead of Print.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2EoRecr
Comprehensive Transcriptomic and Genomic Profiling of Subtypes of Follicular Variant of Papillary Thyroid Carcinoma
Thyroid, Ahead of Print.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2RUT5bG
Persistent/Recurrent Differentiated Thyroid Cancer: Clinical and Radiological Characteristics of Persistent Disease and Clinical Recurrence Based on Computed Tomography Analysis
Thyroid, Ahead of Print.
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Initial Ablation Ratio: Quantitative Value Predicting the Therapeutic Success of Thyroid Radiofrequency Ablation
Thyroid, Ahead of Print.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2EoR9Wb
Pathological Interactions Between Mutant Thyroid Hormone Receptors and Corepressors and Their Modulation by a Thyroid Hormone Analogue with Therapeutic Potential
Thyroid, Ahead of Print.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2EqSmfs
Gasless Transaxillary Endoscopic Thyroidectomy with Robotic Assistance: A High-Volume Experience in North America
Thyroid, Ahead of Print.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2RSriIN
Response to Lenvatinib in Children with Papillary Thyroid Carcinoma
Thyroid, Ahead of Print.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2EoRecr
Comprehensive Transcriptomic and Genomic Profiling of Subtypes of Follicular Variant of Papillary Thyroid Carcinoma
Thyroid, Ahead of Print.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2RUT5bG
Initial Ablation Ratio: Quantitative Value Predicting the Therapeutic Success of Thyroid Radiofrequency Ablation
Thyroid, Ahead of Print.
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Total mandibular reconstruction following diffuse sclerosing osteomyelitis
Abstract
Background
Diffuse sclerosing osteomyelitis (DSO) is a non-purulent chronic recurrent inflammation and affects the mandible in many cases. Belonging to the group of autoinflammatory diseases, in children and in cases with various additional symptoms including synovitis, acne, pustulosis, hyerostosis, and osteitis (SAPHO syndrome), therapy usually consists of non-surgical treatment. Against this background, we present an unusual course of DSO in an adult female patient.
Case report
A 50-year-old female suffering from DSO without SAPHO syndrome was pretreated for years with conservative drug regimens and local surgery. Previous therapy was not successful, and subsequently, multiple surgical procedures were carried out focused on recurrent acute exacerbations of DSO. Surgery resulted in a total resection and alloplastic and autoplastic reconstruction of the mandible including both temporomandibular joints. Prosthetic rehabilitation was possible after dental implant loading, and the final outcome was very satisfactory.
Conclusion
In the event that non-surgical options are not successful in DSO, an extended surgical therapy becomes necessary. Even if surgery results in complete resection of the mandible, a satisfactory rehabilitation can be achieved after complex reconstruction.
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A preliminary study on plasma concentration achieved following intrapterygomandibular space injection of dexamethasone as a route of drug delivery with lignocaine inferior alveolar nerve block–correlation of clinical effects
Abstract
Purpose
To determine the quantity of dexamethasone plasma concentration achieved following intrapterygomandibular space injection of dexamethasone when co-administered with inferior alveolar nerve block correlating with the clinical effects in the postoperative phase.
Objective
A preliminary prospective study to evaluate the dexamethasone plasma concentration achieved following intrapterygomandibular space injection of dexamethasone with 2% lignocaine inferior alveolar nerve block to achieve hemi-mandibular anesthesia for minor oral surgical procedures and derive clinical correlations.
Background
Dexamethasone is a glucocorticoid, chiefly used for the management of postsurgical sequelae like trismus and swelling in maxillofacial surgical practice. Conventionally, parenteral dexamethasone is administered via intravenous or intramuscular route. Intrapterygomandibular space injection is a novel route of steroid delivery described in literature. For minor oral surgical procedures in maxillofacial surgical practice requiring inferior alveolar nerve block, dexamethasone can be administered along with local anesthetic through a single injection as a mixture (twin mix).
Methods
Prospective double-blind randomized clinical trial was designed to evaluative plasma concentration of dexamethasone achieved following injection of a freshly prepared mixture of 1.8 ml of 2% lignocaine with adrenaline (1:200000) and 1 ml (4 mg) dexamethasone [2.8 ml solution of twin mix] in the pterygomandibular space. The 30 candidates included for the trial were randomly split into three study groups (ten each)—(1) control group (C); (2) intramuscular group (IM); (3) intraspace group (IS).
Results
The mean plasma dexamethasone concentration at 30 min postinjection in group IM was 226.41 ± 48.67 ng/ml and for IS group it was 209.67 ± 88.13 ng/ml. Post hoc (Bonferroni-Holm test) intergroup comparison for plasma dexamethasone concentration (IM and IS) was found statistically insignificant (P = 0.605).
Conclusion
Intraspace route of drug administration can be utilized to deliver dexamethasonized local anesthetics safely with predictable clinical effects in the patients requiring mandibular minor oral surgery under local anesthesia.
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Total mandibular reconstruction following diffuse sclerosing osteomyelitis
Abstract
Background
Diffuse sclerosing osteomyelitis (DSO) is a non-purulent chronic recurrent inflammation and affects the mandible in many cases. Belonging to the group of autoinflammatory diseases, in children and in cases with various additional symptoms including synovitis, acne, pustulosis, hyerostosis, and osteitis (SAPHO syndrome), therapy usually consists of non-surgical treatment. Against this background, we present an unusual course of DSO in an adult female patient.
Case report
A 50-year-old female suffering from DSO without SAPHO syndrome was pretreated for years with conservative drug regimens and local surgery. Previous therapy was not successful, and subsequently, multiple surgical procedures were carried out focused on recurrent acute exacerbations of DSO. Surgery resulted in a total resection and alloplastic and autoplastic reconstruction of the mandible including both temporomandibular joints. Prosthetic rehabilitation was possible after dental implant loading, and the final outcome was very satisfactory.
Conclusion
In the event that non-surgical options are not successful in DSO, an extended surgical therapy becomes necessary. Even if surgery results in complete resection of the mandible, a satisfactory rehabilitation can be achieved after complex reconstruction.
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Complication rate in mandibular angle fractures—one vs. two plates: a 12-year retrospective analysis
Abstract
Purpose
Treatment of mandibular angle fractures using one or two osteosynthesis plates is still a controversial topic. Fracture, treatment, and patient-dependent influencing factors could affect the overall outcome. In the present retrospective study, complication rates of mandibular angle fractures treated by open reduction were assessed according to type of treatment.
Materials and methods
We analyzed retrospective medical records using the search terms "mandibular angle fracture." We included all patients presenting with a mandibular angle fracture treated by open reduction and internal fixation at our department between 2002 and 2012.
Results
We included 186 patients treated with open reduction and miniplate fixation (84 one plate; 102 two plates). The early complication rate was significantly higher for the double-plate group (72.5% vs. 47.6%, respectively; p = 0.001). Most common findings in the postoperative period were transient hypoesthesia and tissue swelling. In the two-plate group, a significantly increased operation time of 183 min versus 150 min in the one-plate group was found (p < 0.001). Late complications did not differ significantly between both groups (21.4% single-plate group; 30.4% two-plate fixation group; p = 0.32).
Conclusion
We found a significantly increased early complication rate in the two-plate group. Long-term complications did not differ between both groups.
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[Immunotherapy in castration resistant prostate cancer.]
Authors: Miñana López B, Villacampa Aubá F, de Fata Chillón FR, Ancizu Markert FJ, García Cortés A, Doménech López P, Chiva San Román S, Velis Campillo JM, Díez-Caballero Alonso F, Robles García JE, Rosell Costa D, Pascual Piédrola JI Abstract We review the role of immunotherapy in castration resistant prostate cancer. Two immunotherapeutic strategies have been applied, isolated or in combination, either with each other or with other agents with demonstrated efficacy in this scenario that would play a role as immunomodulators: vaccines or monoclonal antibodies aimed to block immune response checkpoint inhibitors. Although CRPC presents, a priori, characteristics suggesting that immunotherapy may play a relevant role as a therapeutic strategy, its clinical application ha...
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Probiotic Lactobacillus Plantarum 299v decreases kynurenine concentration and improves cognitive functions in patients with major depression: A double-blind, randomized, placebo controlled study
In recent years, the role of intestinal microbiota, as a component of the microbiota-gut-brain axis, has become an important player in neuroscience and psychiatric research. Animal and human studies point out the role of those bacteria in maintaining the psycho-neuro-immunological balance through various actions, such as the modulation of the immune and the neuroendocrine systems e.g. hypothalamic-pituitary adrenal axis (HPA), changes of the TRP metabolism in the serotonin (5-HT) and the kynurenine axes, regulation of the neurogenesis and improvement of intestinal permeability. (Source: Psychoneuroendocrinology)
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[Immunotherapy in castration resistant prostate cancer.]
Authors: Miñana López B, Villacampa Aubá F, de Fata Chillón FR, Ancizu Markert FJ, García Cortés A, Doménech López P, Chiva San Román S, Velis Campillo JM, Díez-Caballero Alonso F, Robles García JE, Rosell Costa D, Pascual Piédrola JI Abstract We review the role of immunotherapy in castration resistant prostate cancer. Two immunotherapeutic strategies have been applied, isolated or in combination, either with each other or with other agents with demonstrated efficacy in this scenario that would play a role as immunomodulators: vaccines or monoclonal antibodies aimed to block immune response checkpoint inhibitors. Although CRPC presents, a priori, characteristics suggesting that immunotherapy may play a relevant role as a therapeutic strategy, its clinical application ha...
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[Drug-induced interstitial pneumonitis due to avelumab: A case report].
CONCLUSION: Avelumab can induce interstitial lung disease. The mechanism is uncertain and requires further studies. Monitoring of respiratory function and CT scanning are necessary for its early management. PMID: 30318432 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
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Probiotic Lactobacillus Plantarum 299v decreases kynurenine concentration and improves cognitive functions in patients with major depression: A double-blind, randomized, placebo controlled study
In recent years, the role of intestinal microbiota, as a component of the microbiota-gut-brain axis, has become an important player in neuroscience and psychiatric research. Animal and human studies point out the role of those bacteria in maintaining the psycho-neuro-immunological balance through various actions, such as the modulation of the immune and the neuroendocrine systems e.g. hypothalamic-pituitary adrenal axis (HPA), changes of the TRP metabolism in the serotonin (5-HT) and the kynurenine axes, regulation of the neurogenesis and improvement of intestinal permeability. (Source: Psychoneuroendocrinology)
MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
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c-Myc Is a Major Determinant for Antitumor Activity of Aurora A Kinase Inhibitor MLN8237 in Thyroid Cancer
Thyroid, Ahead of Print.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2NK934R
Persistent/Recurrent Differentiated Thyroid Cancer: Clinical and Radiological Characteristics of Persistent Disease and Clinical Recurrence Based on Computed Tomography Analysis
Thyroid, Ahead of Print.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2pUHNHp
Pathological Interactions Between Mutant Thyroid Hormone Receptors and Corepressors and Their Modulation by a Thyroid Hormone Analogue with Therapeutic Potential
Thyroid, Ahead of Print.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2NLr9n4
Gasless Transaxillary Endoscopic Thyroidectomy with Robotic Assistance: A High-Volume Experience in North America
Thyroid, Ahead of Print.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2pXkHzZ
Response to Lenvatinib in Children with Papillary Thyroid Carcinoma
Thyroid, Ahead of Print.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2NMul1Y
Initial Ablation Ratio: Quantitative Value Predicting the Therapeutic Success of Thyroid Radiofrequency Ablation
Thyroid, Ahead of Print.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2NL0uae
Persistent/Recurrent Differentiated Thyroid Cancer: Clinical and Radiological Characteristics of Persistent Disease and Clinical Recurrence Based on Computed Tomography Analysis
Thyroid, Ahead of Print.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2pUHNHp
Pathological Interactions Between Mutant Thyroid Hormone Receptors and Corepressors and Their Modulation by a Thyroid Hormone Analogue with Therapeutic Potential
Thyroid, Ahead of Print.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2NLr9n4
Comprehensive Transcriptomic and Genomic Profiling of Subtypes of Follicular Variant of Papillary Thyroid Carcinoma
Thyroid, Ahead of Print.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2pVdBvV
Initial Ablation Ratio: Quantitative Value Predicting the Therapeutic Success of Thyroid Radiofrequency Ablation
Thyroid, Ahead of Print.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2NL0uae
A deafness-associated mitochondrial DNA mutation altered the tRNASer(UCN) metabolism and mitochondrial function
In this study, we investigated the pathogenic mechanism of deafness-associated 7505A > G variant in the mitochondrial tRNASer(UCN). The m.7505A > G variant affected the highly conserved adenine at position 11 (A11), disrupted the highly conserved A11-U24 base-pairing of DHU stem of tRNASer(UCN) and introduced a tertiary base pairing (G11-C56) with the C56 in the TΨC loop. We therefore hypothesized that the m.7505A > G variant altered both structure and function of tRNASer(UCN). We demonstrated that the m.7505A > G variant perturbed the conformation and stability of tRNASer(UCN), as indicated by an increased melting temperature and electrophoretic mobility of the mutated tRNA compared with the wild type molecule. Using the cybrids constructed by transferring mitochondria fr...
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Does endoscopic stapedotomy increase hearing restoration rates comparing to microscopic? A systematic review and meta-analysis
ConclusionAs of yet, endoscopic surgery does not seem to confer benefit on audiological improvement comparing to conventional microscopic, however, it leads to less scutum drilling and fewer postoperative dysgeusia cases. High-quality, large-sample studies need to be performed in the future. (Source: European Archives of Oto-Rhino-Laryngology)
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INDOOR OUTDOOR ALLERGY RELIEF (Fexofenadine Hcl) Tablet, Coated [Walgreens]
Updated Date: Oct 11, 2018 EST (Source: DailyMed Drug Label Updates)
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ALL DAY ALLERGY RELIEF (Cetirizine Hcl) Tablet [McKesson (Sunmark)]
Updated Date: Oct 11, 2018 EST (Source: DailyMed Drug Label Updates)
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GOOD SENSE ALLERGY RELIEF (Loratadine) Tablet [L. Perrigo Company]
Updated Date: Oct 11, 2018 EST (Source: DailyMed Drug Label Updates)
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CHILDRENS ALLERGY DYE-FREE WAL DRYL (Diphenhydramine Hcl) Tablet, Chewable [Walgreen Company]
Updated Date: Oct 11, 2018 EST (Source: DailyMed Drug Label Updates)
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STANDARDIZED CAT HAIR (Felis Domesticus Hair) Injection, Solution [Allergy Laboratories, Inc.]
Updated Date: Oct 11, 2018 EST (Source: DailyMed Drug Label Updates)
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A deafness-associated mitochondrial DNA mutation altered the tRNASer(UCN) metabolism and mitochondrial function
In this study, we investigated the pathogenic mechanism of deafness-associated 7505A > G variant in the mitochondrial tRNASer(UCN). The m.7505A > G variant affected the highly conserved adenine at position 11 (A11), disrupted the highly conserved A11-U24 base-pairing of DHU stem of tRNASer(UCN) and introduced a tertiary base pairing (G11-C56) with the C56 in the TΨC loop. We therefore hypothesized that the m.7505A > G variant altered both structure and function of tRNASer(UCN). We demonstrated that the m.7505A > G variant perturbed the conformation and stability of tRNASer(UCN), as indicated by an increased melting temperature and electrophoretic mobility of the mutated tRNA compared with the wild type molecule. Using the cybrids constructed by transferring mitochondria fr...
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ALLERGY (Loratadine) Tablet [REMEDYREPACK INC.]
Updated Date: Oct 11, 2018 EST (Source: DailyMed Drug Label Updates)
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Conflicting ideologies of English in Korea: Study of bilingual adolescents
This study presented both quantitative findings with turn and qualitative findings through narratives of case study in order to understand the students' language choices and the language ideologies embedded in families. The findings showed that their language choices are influenced by a few different elements. First, the interlocutors were a crucial affecting element of the participants' language choices in the contexts of Korean monolingual ideology. The peer groups also influenced the bilinguals' language choices. Above all, the parents' attitudes influenced by social ideologies affected the bilingual students' main language use. This study emphasizes the complexities of language choices of Korean bilingual adolescents, referring to the contradictions between the ideologies of ...
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Differential effects of negative and positive emotional content over veridical and false recognition in aging and Alzheimer's disease
Publication date: February 2019Source: Journal of Neurolinguistics, Volume 49Author(s): Javier Rodríguez-Ferreiro, Carmen Martínez, Fernando CuetosAbstractAlzheimer's disease (AD) patients are known to present semantic memory impairments, and semantic processing plays a crucial role in the formation of false memories. We assessed 40 early stage AD patients and 35 matched healthy volunteers with an emotional version of the Deese-Roediger-McDermott paradigm, which allows the study of false memory formation. Participants were presented with three negative, three neutral and three positive lists of words, each semantically associated to a critical unpresented word. After the presentation of the lists the volunteers were asked to respond to a recognition questionnaire stating whether these cr...
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Disclosure of stuttering and quality of life in people who stutter
ConclusionsAttempts to conceal stuttering in at least some life situations are not uncommon among adults who stutter. However, being involved in self-help support groups may be a helpful way of increasing disclosure of stuttering. Speech-language pathologists should become aware of the positive relationship between disclosure of stuttering and quality of life and its relevance in assessment and treatment when working with people who stutter. (Source: Journal of Fluency Disorders)
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An epidemiological profile of communication disability among older adults with complex needs: A national cross-sectional study
. (Source: International Journal of Speech-Language Pathology)
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INDOOR OUTDOOR ALLERGY RELIEF (Fexofenadine Hcl) Tablet, Coated [Walgreens]
Updated Date: Oct 11, 2018 EST (Source: DailyMed Drug Label Updates)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PxZnfE
ALL DAY ALLERGY RELIEF (Cetirizine Hcl) Tablet [McKesson (Sunmark)]
Updated Date: Oct 11, 2018 EST (Source: DailyMed Drug Label Updates)
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CHILDRENS ALLERGY DYE-FREE WAL DRYL (Diphenhydramine Hcl) Tablet, Chewable [Walgreen Company]
Updated Date: Oct 11, 2018 EST (Source: DailyMed Drug Label Updates)
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ALLERGY RELIEF (Cetirizine Hcl) Tablet [Walgreens]
Updated Date: Oct 11, 2018 EST (Source: DailyMed Drug Label Updates)
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STANDARDIZED CAT HAIR (Felis Domesticus Hair) Injection, Solution [Allergy Laboratories, Inc.]
Updated Date: Oct 11, 2018 EST (Source: DailyMed Drug Label Updates)
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Conflicting ideologies of English in Korea: Study of bilingual adolescents
This study presented both quantitative findings with turn and qualitative findings through narratives of case study in order to understand the students' language choices and the language ideologies embedded in families. The findings showed that their language choices are influenced by a few different elements. First, the interlocutors were a crucial affecting element of the participants' language choices in the contexts of Korean monolingual ideology. The peer groups also influenced the bilinguals' language choices. Above all, the parents' attitudes influenced by social ideologies affected the bilingual students' main language use. This study emphasizes the complexities of language choices of Korean bilingual adolescents, referring to the contradictions between the ideologies of ...
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Differential effects of negative and positive emotional content over veridical and false recognition in aging and Alzheimer's disease
Publication date: February 2019Source: Journal of Neurolinguistics, Volume 49Author(s): Javier Rodríguez-Ferreiro, Carmen Martínez, Fernando CuetosAbstractAlzheimer's disease (AD) patients are known to present semantic memory impairments, and semantic processing plays a crucial role in the formation of false memories. We assessed 40 early stage AD patients and 35 matched healthy volunteers with an emotional version of the Deese-Roediger-McDermott paradigm, which allows the study of false memory formation. Participants were presented with three negative, three neutral and three positive lists of words, each semantically associated to a critical unpresented word. After the presentation of the lists the volunteers were asked to respond to a recognition questionnaire stating whether these cr...
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An epidemiological profile of communication disability among older adults with complex needs: A national cross-sectional study
. (Source: International Journal of Speech-Language Pathology)
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Genomic mutations and proof of causation between dysplasia and squamous cell carcinoma in medicolegal cases: a useful approach or a waste of resources?
It has been suggested that oral stratified squamous epithelium may be implicated in field cancerisation.1,2 Several other studies have examined the clonal relations between dysplasia and oral squamous cell carcinoma (SCC),3,4 and it is now obvious that the relation between dysplasia at a specific site in the oral cavity, and a subsequent SCC that has arisen at the same site several years later, is a complex rather than a simple progression.5 Those of us who see patients with mucosal abnormalities often treat lesions with low-grade or high-grade dysplasia.
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Genomic mutations and proof of causation between dysplasia and squamous cell carcinoma in medicolegal cases: a useful approach or a waste of resources?
It has been suggested that oral stratified squamous epithelium may be implicated in field cancerisation.1,2 Several other studies have examined the clonal relations between dysplasia and oral squamous cell carcinoma (SCC),3,4 and it is now obvious that the relation between dysplasia at a specific site in the oral cavity, and a subsequent SCC that has arisen at the same site several years later, is a complex rather than a simple progression.5 Those of us who see patients with mucosal abnormalities often treat lesions with low-grade or high-grade dysplasia.
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Current approaches to instrumental assessment of swallowing in children
Purpose of the review This article reviews recent developments in the instrumental assessment of swallowing in children with a specific focus on research published between January 2017 and June 2018. Recent findings Instrumental swallowing assessments reported in the time period included: videofluoroscopic study of swallowing, digital cervical auscultation, dynamic ultrasound, high-resolution impedance manometry, nasal airflow thermistry and respiratory inductance plethysmography. Several studies were found exploring tools to objectively quantify videofluoroscopic study of swallowing data; swallowing from the mouth through to stomach was addressed including approaches to analysing mastication as well as evaluating oesophageal motility disorders. Summary Even though a vast range of instrumentation were studied, lack of clarity on clinical feasibility and objective measures that facilitate medical decision-making in practice mean further research is required to provide guidance on implementation. Promising novel approaches to aid the quantification of swallowing physiology from the mouth, pharynx and through to the oesophagus are emerging. Correspondence to Isuru Dharmarathna, BSc, Speech Science, School of Psychology, Tamaki Campus, The University of Auckland, Private Bag 92019, Auckland, New Zealand. Tel: +64 9 923 8177; fax: +64 9 373 7902; e-mail: pdha800@aucklanduni.ac.nz Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.
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Accuracy and Reliability of Mandibular Digital Model Registration Using the Mucogingival Junction as a Reference
To validate a method of mandibular digital model (DM) registration, acquired from an intraoral scanner, compared to high-resolution voxel-based cone beam computed tomography (CBCT) registration using the mucogingival junction as a reference.
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A comparison of panoramic radiography and cone beam CT in the detection of osteosynthesis complications in sheep mandibular angle fractures
To compare the diagnostic efficacy of panoramic radiography (PANO) and cone beam computed tomography (CBCT) in detecting simulated complications of plate osteosynthesis applied to mandibular angle fractures (MAFs).
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Engulfment of mast cell secretory granules upon skin inflammation boosts dendritic cell migration and priming efficiency
Dudeck et al. demonstrate that MC granules are engulfed by DCs upon skin inflammation and actively shuttled to LNs. MC granule uptake boosts DC activation and T cell priming efficiency, thereby enhancing the inflammatory response.
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Immunosuppression for immunodeficiency- getting smarter
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Plasma tryptase elevation during aspirin-induced reactions in aspirin-exacerbated respiratory disease (AERD)
Plasma tryptase elevation during aspirin-induced respiratory reactions occurs in 50% of reactions despite CysLT1R antagonist prophylaxis and identifies lung function decline and extra-respiratory symptoms in aspirin-exacerbated respiratory disease (AERD).
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RhoH deficiency induces psoriasis-like chronic dermatitis by promoting TH17 cell polarization
RhoH could be a risk factor for exacerbation of psoriasis by inhibiting effector function of TH17 cells.
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Accuracy and Reliability of Mandibular Digital Model Registration Using the Mucogingival Junction as a Reference
To validate a method of mandibular digital model (DM) registration, acquired from an intraoral scanner, compared to high-resolution voxel-based cone beam computed tomography (CBCT) registration using the mucogingival junction as a reference.
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A comparison of panoramic radiography and cone beam CT in the detection of osteosynthesis complications in sheep mandibular angle fractures
To compare the diagnostic efficacy of panoramic radiography (PANO) and cone beam computed tomography (CBCT) in detecting simulated complications of plate osteosynthesis applied to mandibular angle fractures (MAFs).
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Engulfment of mast cell secretory granules upon skin inflammation boosts dendritic cell migration and priming efficiency
Dudeck et al. demonstrate that MC granules are engulfed by DCs upon skin inflammation and actively shuttled to LNs. MC granule uptake boosts DC activation and T cell priming efficiency, thereby enhancing the inflammatory response.
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Immunosuppression for immunodeficiency- getting smarter
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2EqsnVG
Plasma tryptase elevation during aspirin-induced reactions in aspirin-exacerbated respiratory disease (AERD)
Plasma tryptase elevation during aspirin-induced respiratory reactions occurs in 50% of reactions despite CysLT1R antagonist prophylaxis and identifies lung function decline and extra-respiratory symptoms in aspirin-exacerbated respiratory disease (AERD).
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2RUMv4H
RhoH deficiency induces psoriasis-like chronic dermatitis by promoting TH17 cell polarization
RhoH could be a risk factor for exacerbation of psoriasis by inhibiting effector function of TH17 cells.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Eqk9Nl
The speech perception after cochlear implantation: The hearing gain difference according to the implant systems is important?
The outcome of cochlear implantation (CI) is affected by various factors, including the manufacturer of the device. We validated the factors contributing to postoperative performance and evaluated the influence of different company devices on pure tone thresholds and postoperative performance.
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The speech perception after cochlear implantation: The hearing gain difference according to the implant systems is important?
The outcome of cochlear implantation (CI) is affected by various factors, including the manufacturer of the device. We validated the factors contributing to postoperative performance and evaluated the influence of different company devices on pure tone thresholds and postoperative performance.
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Development of novel antimicrobial peptides derived from anti-lipopolysaccharide factor of the swimming crab, Portunus trituberculatus
In this study, we successfully developed two novel antimicrobial peptides (AMPs), named crab-ALF2A and crab-ALF6A, which contain changes to the amino acid sequences of the lipopolysaccharide binding domain and signal peptide, respectively, of the ALF of the swimming crab Portunus trituberculatus. The crab-ALF2A peptide showed potent antimicrobial activity against the Gram-positive bacteria Bacillus cereus, Staphylococcus aureus, and Streptococcus iniae (minimal effective concentration [MEC] 1.51–1.93 μg/mL) and the Gram-negative bacteria Pseudomonas aeruginosa and Escherichia coli (MEC 1.87–1.98 μg/mL), with maximal bactericidal activity at a peptide concentration of 5 μg/mL. The crab-ALF6A peptide also showed potent antimicrobial activity against B. cereus, S. aureus, and S. ...
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Deoxynivalenol decreased intestinal immune function related to NF-κB and TOR signalling in juvenile grass carp (Ctenopharyngodon idella)
This study explored the effects of DON on intestinal immune function in juvenile grass carp (Ctenopharyngodon idella). A total of 1440 juvenile grass carp (12.17 ± 0.01g) were fed six diets containing graded levels of DON (27, 318, 636, 922, 1243 and 1515 μg/kg diet) for 60 days. After the growth trial, fish were challenged with Aeromonas hydrophila. The results were analysed by the Duncan's multiple-range test (P < 0.05), indicating that compared with the control group (27 μg/kg diet), dietary DON levels up to 318 μg/kg diet: (1) decreased lysozyme (LZ) and acid phosphatase (ACP) activities, as well as complement 3 (C3), C4 and immunoglobulin M (IgM) content in the proximal intestine (PI), middle intestine (MI) and distal intestine (DI) of juvenile grass carp (P ...
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Identification, characterization and expression in response to Aeromonas hydrophila challenge of five interferon regulatory factors in Megalobrama amblycephala
In this study, we characterized five Irf family members (irf4a, irf4b, irf6, irf8 and irf10) in Megalobrama amblycephala at the cDNA and (predicted) amino acid levels, analyzed them phylogenetically, and developed gene-specific primers for qPCR analysis. All five irfs were constitutively expressed in all examined tissues, but their transcription was significantly higher in lymphoid organs and tissues, such as kidney, spleen and intestine. Exceptions were irf8, which was expressed at a high level in heart and brain tissues, and irf6, expressed at low levels in most tissues. After a bacterial immune challenge with Aeromonas hydrophila, the expression of irfs in liver was up-regulated: mairf4a 8.12-fold, mairf4b 29.9-fold, mairf6 1.38-fold and mairf10 1.65-fold (mairf8 was an exception: 0.07-...
MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
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Sequence analysis and characterization of type I interferon and type II interferon from the critically endangered sturgeon species, A. dabryanus and A. sinensis
Publication date: Available online 15 October 2018Source: Fish & Shellfish ImmunologyAuthor(s): Qiaoqing Xu, Kai Luo, Shuhuan Zhang, Weihua Gao, Wenbing Zhang, Qiwei WeiAbstractIn the present study, we identify three type I interferon (IFN) genes (Ad/AsIFNe1-3) and a type II IFN gene (Ad/AsIFNγ) from the Dabry's sturgeon (Acipenser dabryanus) and the Chinese sturgeon (Acipenser sinensis). Sequence analysis revealed that Ad/AsIFNe1–3 and Ad/AsIFNγ contain several conserved characteristics, including signal peptides, interferon alpha, beta, and delta (IFabd) domains, and N-glycosylation sites. Ad/AsIFNe1-3 belongs to the type I IFN group I subgroup, possessing two conserved cysteines residues (C1 and C3), and Ad/AsIFNγ contained a conserved nuclear localization sequence (NLS) motif. Ad/...
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Novel Ca2+-independent C-type lectin involved in immune defense of the razor clam Sinonovacula constricta
In this study, a full-length cDNA of CTL was cloned from Sinonovacula constricta (designated ScCTL-2). ScCTL-2 has a length of 981 bp, a 5′-untranslated region (UTR) of 47 bp, a short 3′-UTR of 37 bp, and an open reading frame (ORF) of 894 bp, which encodes a polypeptide of 298 amino acid residues. The deduced amino acid of ScCTL-2 possesses a conserved carbohydrate-recognition domain (CRD) similar to that of C31–E171. Spatial distribution analysis demonstrated that ScCTL-2 was constitutively expressed in all tested tissues, with dominant expression in foot and siphon and weak expression in hepatopancreas. The mRNA expression level of ScCTL-2 in gills and hepatopancreas was significantly upregulated at 6 and 12 h after challenge with the pathogen Vibrio parahaemolyticus. The recomb...
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Amphiregulin-producing {gamma}{delta} T cells are vital for safeguarding oral barrier immune homeostasis [Immunology and Inflammation]
γδ T cells are enriched at barrier sites such as the gut, skin, and lung, where their roles in maintaining barrier integrity are well established. However, how these cells contribute to homeostasis at the gingiva, a key oral barrier and site of the common chronic inflammatory disease periodontitis, has not... (Source: Proceedings of the National Academy of Sciences)
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CXCR6+ST2+ memory T helper 2 cells induced the expression of major basic protein in eosinophils to reduce the fecundity of helminth [Immunology and Inflammation]
Memory T helper (mTh) cells play important roles in the reinfection of pathogens and drive the pathogenesis of diseases. While recent studies have characterized the pathogenic mTh2 cell subpopulations driving allergic inflammation, those that induce immune responses against helminth infection remain unknown. We found that IL-5–producing CXCR6+ST2+CD44+ mTh2 cells play... (Source: Proceedings of the National Academy of Sciences)
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Proinsulin C-peptide is an autoantigen in people with type 1 diabetes [Immunology and Inflammation]
Type 1 diabetes (T1D) is an autoimmune disease in which insulin-producing beta cells, found within the islets of Langerhans in the pancreas, are destroyed by islet-infiltrating T cells. Identifying the antigenic targets of beta-cell reactive T cells is critical to gain insight into the pathogenesis of T1D and develop antigen-specific... (Source: Proceedings of the National Academy of Sciences)
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Natural molecules induce and synergize to boost expression of the human antimicrobial peptide {beta}-defensin-3 [Immunology and Inflammation]
Antimicrobial peptides (AMPs) are mucosal defense effectors of the human innate immune response. In the intestine, AMPs are produced and secreted by epithelial cells to protect the host against pathogens and to support homeostasis with commensals. The inducible nature of AMPs suggests that potent inducers could be used to increase... (Source: Proceedings of the National Academy of Sciences)
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Raf kinase inhibitor protein negatively regulates FcϵRI-mediated mast cell activation and allergic response [Immunology and Inflammation]
In this study, we found that... (Source: Proceedings of the National Academy of Sciences)
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Development of novel antimicrobial peptides derived from anti-lipopolysaccharide factor of the swimming crab, Portunus trituberculatus
In this study, we successfully developed two novel antimicrobial peptides (AMPs), named crab-ALF2A and crab-ALF6A, which contain changes to the amino acid sequences of the lipopolysaccharide binding domain and signal peptide, respectively, of the ALF of the swimming crab Portunus trituberculatus. The crab-ALF2A peptide showed potent antimicrobial activity against the Gram-positive bacteria Bacillus cereus, Staphylococcus aureus, and Streptococcus iniae (minimal effective concentration [MEC] 1.51–1.93 μg/mL) and the Gram-negative bacteria Pseudomonas aeruginosa and Escherichia coli (MEC 1.87–1.98 μg/mL), with maximal bactericidal activity at a peptide concentration of 5 μg/mL. The crab-ALF6A peptide also showed potent antimicrobial activity against B. cereus, S. aureus, and S. ...
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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2P1OsxD
Deoxynivalenol decreased intestinal immune function related to NF-κB and TOR signalling in juvenile grass carp (Ctenopharyngodon idella)
This study explored the effects of DON on intestinal immune function in juvenile grass carp (Ctenopharyngodon idella). A total of 1440 juvenile grass carp (12.17 ± 0.01g) were fed six diets containing graded levels of DON (27, 318, 636, 922, 1243 and 1515 μg/kg diet) for 60 days. After the growth trial, fish were challenged with Aeromonas hydrophila. The results were analysed by the Duncan's multiple-range test (P < 0.05), indicating that compared with the control group (27 μg/kg diet), dietary DON levels up to 318 μg/kg diet: (1) decreased lysozyme (LZ) and acid phosphatase (ACP) activities, as well as complement 3 (C3), C4 and immunoglobulin M (IgM) content in the proximal intestine (PI), middle intestine (MI) and distal intestine (DI) of juvenile grass carp (P ...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PCYhzm
Identification, characterization and expression in response to Aeromonas hydrophila challenge of five interferon regulatory factors in Megalobrama amblycephala
In this study, we characterized five Irf family members (irf4a, irf4b, irf6, irf8 and irf10) in Megalobrama amblycephala at the cDNA and (predicted) amino acid levels, analyzed them phylogenetically, and developed gene-specific primers for qPCR analysis. All five irfs were constitutively expressed in all examined tissues, but their transcription was significantly higher in lymphoid organs and tissues, such as kidney, spleen and intestine. Exceptions were irf8, which was expressed at a high level in heart and brain tissues, and irf6, expressed at low levels in most tissues. After a bacterial immune challenge with Aeromonas hydrophila, the expression of irfs in liver was up-regulated: mairf4a 8.12-fold, mairf4b 29.9-fold, mairf6 1.38-fold and mairf10 1.65-fold (mairf8 was an exception: 0.07-...
MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2P5iXmv
Sequence analysis and characterization of type I interferon and type II interferon from the critically endangered sturgeon species, A. dabryanus and A. sinensis
Publication date: Available online 15 October 2018Source: Fish & Shellfish ImmunologyAuthor(s): Qiaoqing Xu, Kai Luo, Shuhuan Zhang, Weihua Gao, Wenbing Zhang, Qiwei WeiAbstractIn the present study, we identify three type I interferon (IFN) genes (Ad/AsIFNe1-3) and a type II IFN gene (Ad/AsIFNγ) from the Dabry's sturgeon (Acipenser dabryanus) and the Chinese sturgeon (Acipenser sinensis). Sequence analysis revealed that Ad/AsIFNe1–3 and Ad/AsIFNγ contain several conserved characteristics, including signal peptides, interferon alpha, beta, and delta (IFabd) domains, and N-glycosylation sites. Ad/AsIFNe1-3 belongs to the type I IFN group I subgroup, possessing two conserved cysteines residues (C1 and C3), and Ad/AsIFNγ contained a conserved nuclear localization sequence (NLS) motif. Ad/...
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The modulation of Smac/DIABLO on mitochondrial apoptosis induced by LPS in Crassostrea gigas
Publication date: Available online 15 October 2018Source: Fish & Shellfish ImmunologyAuthor(s): Zhao Lv, Xiaorui Song, Jiachao Xu, Zhihao Jia, Bin Yang, Yunke Jia, Limei Qiu, Lingling Wang, Linsheng SongAbstractThe mitochondrial pathway of apoptosis is well studied as the major mechanism of physiological cell death in vertebrates. In the present study, a second mitochondria-derived activator of caspases (Smac)/direct inhibitor of apoptosis-binding protein (IAP) with low pI protein (DIABLO) (designated as CgSmac) was identified from oyster Crassostrea gigas. The open reading frame of CgSmac was of 966 bp nucleotides encoding a predicted polypeptide of 321 amino acids with a conserved Smac/DIABLO domain containing a potential IAP-binding motif of VMPV. CgSmac proteins were distributed in hem...
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Novel Ca2+-independent C-type lectin involved in immune defense of the razor clam Sinonovacula constricta
In this study, a full-length cDNA of CTL was cloned from Sinonovacula constricta (designated ScCTL-2). ScCTL-2 has a length of 981 bp, a 5′-untranslated region (UTR) of 47 bp, a short 3′-UTR of 37 bp, and an open reading frame (ORF) of 894 bp, which encodes a polypeptide of 298 amino acid residues. The deduced amino acid of ScCTL-2 possesses a conserved carbohydrate-recognition domain (CRD) similar to that of C31–E171. Spatial distribution analysis demonstrated that ScCTL-2 was constitutively expressed in all tested tissues, with dominant expression in foot and siphon and weak expression in hepatopancreas. The mRNA expression level of ScCTL-2 in gills and hepatopancreas was significantly upregulated at 6 and 12 h after challenge with the pathogen Vibrio parahaemolyticus. The recomb...
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Crystallization of ectonucleotide phosphodiesterase/pyrophosphatase-3 and orientation of the SMB domains in the full-length ectodomain
Ectonucleotide phosphodiesterase/pyrophosphatase-3 (NPP3, ENPP3) is an ATP-hydrolyzing glycoprotein that is located in the extracellular space. The full-length ectodomain of rat NPP3 was expressed in HEK293S GntI − cells, purified using two chromatographic steps and crystallized. Its structure at 2.77 Å resolution reveals that the active-site zinc ions are missing and a large part of the active site and the surrounding residues are flexible. The SMB-like domains have the same orientation in all four molecules in the asymmetric unit. The SMB2 domain is oriented as in NPP2, but the SMB1 domain does not interact with the PDE domain but extends further away from the PDE domain. Deletion of the SMB domains resulted in crystals that diffracted to 2.4 Å resolution and are suitable for...
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Amphiregulin-producing {gamma}{delta} T cells are vital for safeguarding oral barrier immune homeostasis [Immunology and Inflammation]
γδ T cells are enriched at barrier sites such as the gut, skin, and lung, where their roles in maintaining barrier integrity are well established. However, how these cells contribute to homeostasis at the gingiva, a key oral barrier and site of the common chronic inflammatory disease periodontitis, has not... (Source: Proceedings of the National Academy of Sciences)
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CXCR6+ST2+ memory T helper 2 cells induced the expression of major basic protein in eosinophils to reduce the fecundity of helminth [Immunology and Inflammation]
Memory T helper (mTh) cells play important roles in the reinfection of pathogens and drive the pathogenesis of diseases. While recent studies have characterized the pathogenic mTh2 cell subpopulations driving allergic inflammation, those that induce immune responses against helminth infection remain unknown. We found that IL-5–producing CXCR6+ST2+CD44+ mTh2 cells play... (Source: Proceedings of the National Academy of Sciences)
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Proinsulin C-peptide is an autoantigen in people with type 1 diabetes [Immunology and Inflammation]
Type 1 diabetes (T1D) is an autoimmune disease in which insulin-producing beta cells, found within the islets of Langerhans in the pancreas, are destroyed by islet-infiltrating T cells. Identifying the antigenic targets of beta-cell reactive T cells is critical to gain insight into the pathogenesis of T1D and develop antigen-specific... (Source: Proceedings of the National Academy of Sciences)
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Notch2-dependent DC2s mediate splenic germinal center responses [Immunology and Inflammation]
CD4+ T follicular helper (TFH) cells support germinal center (GC) reactions promoting humoral immunity. Dendritic cell (DC) diversification into genetically distinct subsets allows for specialization in promoting responses against several types of pathogens. Whether any classical DC (cDC) subset is required for humoral immunity is unknown, however. We tested several... (Source: Proceedings of the National Academy of Sciences)
MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2P0VtPl
Natural molecules induce and synergize to boost expression of the human antimicrobial peptide {beta}-defensin-3 [Immunology and Inflammation]
Antimicrobial peptides (AMPs) are mucosal defense effectors of the human innate immune response. In the intestine, AMPs are produced and secreted by epithelial cells to protect the host against pathogens and to support homeostasis with commensals. The inducible nature of AMPs suggests that potent inducers could be used to increase... (Source: Proceedings of the National Academy of Sciences)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PDxFyj
Raf kinase inhibitor protein negatively regulates FcϵRI-mediated mast cell activation and allergic response [Immunology and Inflammation]
In this study, we found that... (Source: Proceedings of the National Academy of Sciences)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2P5CfYU
Long-term implant failure in patients treated for oral cancer by external radiotherapy: a retrospective monocentric study
Source: Journal of Oral Medicine and oral Surgery, JOMOS Date: October 10th, 2018 Authors: Aline Desoutter, Sophie Deneuve, Sophie-Charlotte Condamin and Anne-Gaëlle Chaux-Bodard […]
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Imaging portal venous flow to aid assessment of right ventricular dysfunction
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Atlas of Common Pain Syndromes, Fourth Edition
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Should we ever stop clinical trials for efficacy?
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In reply: Another easy method to reduce syringe swapping
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In reply: Should we ever stop clinical trials for efficacy?
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Perioperative pregabalin and delirium following total hip arthroplasty: a post hoc analysis of a double-blind randomized placebo-controlled trial
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The distinctly Canadian origins of cyclopropane
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Audit and feedback: to tell or not to tell? That is not the question
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Long-term implant failure in patients treated for oral cancer by external radiotherapy: a retrospective monocentric study
Source: Journal of Oral Medicine and oral Surgery, JOMOS Date: October 10th, 2018 Authors: Aline Desoutter, Sophie Deneuve, Sophie-Charlotte Condamin and Anne-Gaëlle Chaux-Bodard […]
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Effect of audit and feedback on physicians’ intraoperative temperature management and patient outcomes: a three-arm cluster randomized - controlled trial comparing benchmarked and ranked feedback
Abstract
Purpose
Audit and feedback can improve physicians' practice; however, the most effective type of feedback is unknown. Inadvertent perioperative hypothermia is associated with postoperative complications and remains common despite the use of effective and safe warming devices. This study aimed to measure the impact of targeted audit and feedback on anesthesiologists' intraoperative temperature management and subsequent patient outcomes.
Methods
This study was a three-arm cluster randomized-controlled trial. Anesthesiologists' intraoperative temperature management performance was analyzed in two phases. The first was a baseline phase with audit but no feedback for eight months, followed by an intervention phase over the next seven-month period after participants had received interventions according to their randomized group allocation of no feedback (control), benchmarked feedback, or ranked feedback. Anesthesiologists' percentage of hypothermic patients at the end of surgery (primary endpoint) and use of a warming device were compared among the groups.
Results
Forty-five attending anesthesiologists who took care of 7,846 patients over 15 months were included. The odds of hypothermia (temperature < 36°C at the end of surgery) increased significantly from pre- to post-intervention in the control and ranked groups (control odds ratio [OR], 1.27; 95% confidence interval [CI], 1.03 to 1.56; P = 0.02; ranked OR, 1.26; 95% CI, 1.01 to 1.56; P = 0.04) but not in the benchmarked group (OR, 1.05; 95% CI, 0.87 to 1.28; P = 0.58). Between-arm differences in pre- to post-intervention changes were not significant (benchmark vs control OR, 0.83; 95% CI, 0.62 to 1.10; P = 0.19; ranked vs control OR, 0.99; 95% CI, 0.73 to 1.33, P = 0.94). No significant overall effect on intraoperative warmer use change was detected.
Conclusion
We found no evidence to suggest that audit and feedback, using benchmarked or ranked feedback, is more effective than no feedback at all to change anesthesiologists' intraoperative temperature management performance. Feedback may need to be included in a bundle to produce its effect.
Trials registration
www.clinicaltrials.gov (NCT02414191). Registered 19 March 2015.
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Evaluating two techniques for potentially increasing radial artery size in a follow-up study involving patients with peripheral vascular disease
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Association between albumin administration and survival in cardiac surgery: a retrospective cohort study
Abstract
Purpose
Albumin is widely used during and after on-pump cardiac surgery, although it is unclear whether this therapy improves clinical outcomes.
Methods
This observational study utilized the Cerner Health Facts® database (a large HIPAA-compliant clinical-administrative database maintained by Cerner Inc., USA) to identify a cohort of 6,188 adults that underwent on-pump cardiac surgery for valve and/or coronary artery procedures between January 2001 and March 2013. Of these, 1,095 patients who received 5% albumin with crystalloid solutions and 1,095 patients who received crystalloids alone on the day of or the day following cardiac surgery were selected by propensity-score matching. The primary outcome was all-cause in-hospital mortality. Three secondary outcomes analyzed include acute kidney injury severity, major morbidity composite, and all-cause 30-day readmissions.
Results
In the propensity-score matched cohort, receipt of perioperative 5% albumin was associated with decreased risk of in-hospital mortality (odds ratio [OR], 0.5; 95% confidence interval [CI], 0.3 to 0.9; P = 0.02) and lower all-cause 30-day readmission rates (OR, 0.7; 98.3% CI, 0.5 to 0.9; P < 0.01). Albumin therapy was not associated with differences in overall major morbidity (OR, 0.9; 98.3% CI, 0.7 to 1.2; P = 0.39; composite) or acute kidney injury severity (OR, 0.9; 98.3% CI, 0.6 to 1.4; P = 0.53) compared with therapy with crystalloid solutions.
Conclusions
In this large retrospective study, use of 5% albumin solution was associated with significantly decreased odds of in-hospital mortality and all-cause 30-day readmission rate compared with administration of crystalloids alone in adult patients undergoing on-pump cardiac surgery. These results warrant further studies to examine fluid receipt, including 5% albumin, in surgical populations via randomized-controlled trials.
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Should we ever stop clinical trials for efficacy?
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2EnZIAs
In reply: Another easy method to reduce syringe swapping
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2RZRaTg
In reply: Should we ever stop clinical trials for efficacy?
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2RZQI7w
Another easy method to reduce syringe swapping
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2EsaXIa
Perioperative pregabalin and delirium following total hip arthroplasty: a post hoc analysis of a double-blind randomized placebo-controlled trial
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2RS3m8p
Audit and feedback: to tell or not to tell? That is not the question
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A cross-sectional study of the reporting quality of pilot or feasibility trials in high-impact anesthesia journals
Abstract
Purpose
Pilot trials inform the design and conduct of larger scale trials. Using the Consolidated Standards of Reporting Trials (CONSORT) pilot extension guidelines, we assessed reporting quality in five high-impact anesthesia journals and explored factors associated with reporting quality.
Methods
The five highest-impact anesthesia journals were screened for randomized-controlled trials published as pilot or feasibility trials between 2006 and 2016. A pair of reviewers independently screened citations, extracted data, and assessed reporting quality using the CONSORT pilot trial extension checklists for abstracts and full texts. We reported the percentage adherence for each item, along with the median [interquartile range (IQR)] or mean (standard deviation [SD]) for all items. The factors considered to influence reporting were: 1) trial registration, 2) industry funding, 3) trial identification as a pilot or feasibility in the title or abstract, 4) primary objective as "feasibility", and 5) the specific journal. The association was estimated using generalized estimating equations and reported as incidence rate ratios with 99% confidence intervals.
Results
Of 364 citations, 58 articles were eligible. The median [IQR] number of CONSORT abstract items reported was 5 [4-7], and the mean (SD) number of full text items reported was 13 (5). Significantly poor reporting was associated with "not registering the trial" (both abstracts and full texts), "trial not identified as a pilot" (abstracts), and "using clinical hypothesis as the primary objective" (full texts).
Conclusion
The reporting quality of pilot trials published in leading anesthesia journals is poor. Journal editorial boards can encourage improved reporting by supporting adherence to the CONSORT extension for pilot trials.
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Eyelid injury after use of 3M Durapore™ tape during general anesthesia
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Effect of audit and feedback on physicians’ intraoperative temperature management and patient outcomes: a three-arm cluster randomized - controlled trial comparing benchmarked and ranked feedback
Abstract
Purpose
Audit and feedback can improve physicians' practice; however, the most effective type of feedback is unknown. Inadvertent perioperative hypothermia is associated with postoperative complications and remains common despite the use of effective and safe warming devices. This study aimed to measure the impact of targeted audit and feedback on anesthesiologists' intraoperative temperature management and subsequent patient outcomes.
Methods
This study was a three-arm cluster randomized-controlled trial. Anesthesiologists' intraoperative temperature management performance was analyzed in two phases. The first was a baseline phase with audit but no feedback for eight months, followed by an intervention phase over the next seven-month period after participants had received interventions according to their randomized group allocation of no feedback (control), benchmarked feedback, or ranked feedback. Anesthesiologists' percentage of hypothermic patients at the end of surgery (primary endpoint) and use of a warming device were compared among the groups.
Results
Forty-five attending anesthesiologists who took care of 7,846 patients over 15 months were included. The odds of hypothermia (temperature < 36°C at the end of surgery) increased significantly from pre- to post-intervention in the control and ranked groups (control odds ratio [OR], 1.27; 95% confidence interval [CI], 1.03 to 1.56; P = 0.02; ranked OR, 1.26; 95% CI, 1.01 to 1.56; P = 0.04) but not in the benchmarked group (OR, 1.05; 95% CI, 0.87 to 1.28; P = 0.58). Between-arm differences in pre- to post-intervention changes were not significant (benchmark vs control OR, 0.83; 95% CI, 0.62 to 1.10; P = 0.19; ranked vs control OR, 0.99; 95% CI, 0.73 to 1.33, P = 0.94). No significant overall effect on intraoperative warmer use change was detected.
Conclusion
We found no evidence to suggest that audit and feedback, using benchmarked or ranked feedback, is more effective than no feedback at all to change anesthesiologists' intraoperative temperature management performance. Feedback may need to be included in a bundle to produce its effect.
Trials registration
www.clinicaltrials.gov (NCT02414191). Registered 19 March 2015.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Enl4hy
Evaluating two techniques for potentially increasing radial artery size in a follow-up study involving patients with peripheral vascular disease
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2RSqcwJ
Association between albumin administration and survival in cardiac surgery: a retrospective cohort study
Abstract
Purpose
Albumin is widely used during and after on-pump cardiac surgery, although it is unclear whether this therapy improves clinical outcomes.
Methods
This observational study utilized the Cerner Health Facts® database (a large HIPAA-compliant clinical-administrative database maintained by Cerner Inc., USA) to identify a cohort of 6,188 adults that underwent on-pump cardiac surgery for valve and/or coronary artery procedures between January 2001 and March 2013. Of these, 1,095 patients who received 5% albumin with crystalloid solutions and 1,095 patients who received crystalloids alone on the day of or the day following cardiac surgery were selected by propensity-score matching. The primary outcome was all-cause in-hospital mortality. Three secondary outcomes analyzed include acute kidney injury severity, major morbidity composite, and all-cause 30-day readmissions.
Results
In the propensity-score matched cohort, receipt of perioperative 5% albumin was associated with decreased risk of in-hospital mortality (odds ratio [OR], 0.5; 95% confidence interval [CI], 0.3 to 0.9; P = 0.02) and lower all-cause 30-day readmission rates (OR, 0.7; 98.3% CI, 0.5 to 0.9; P < 0.01). Albumin therapy was not associated with differences in overall major morbidity (OR, 0.9; 98.3% CI, 0.7 to 1.2; P = 0.39; composite) or acute kidney injury severity (OR, 0.9; 98.3% CI, 0.6 to 1.4; P = 0.53) compared with therapy with crystalloid solutions.
Conclusions
In this large retrospective study, use of 5% albumin solution was associated with significantly decreased odds of in-hospital mortality and all-cause 30-day readmission rate compared with administration of crystalloids alone in adult patients undergoing on-pump cardiac surgery. These results warrant further studies to examine fluid receipt, including 5% albumin, in surgical populations via randomized-controlled trials.
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Imaging portal venous flow to aid assessment of right ventricular dysfunction
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Atlas of Common Pain Syndromes, Fourth Edition
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Should we ever stop clinical trials for efficacy?
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In reply: Should we ever stop clinical trials for efficacy?
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