The modulation of Smac/DIABLO on mitochondrial apoptosis induced by LPS in Crassostrea gigas

Publication date: Available online 15 October 2018Source: Fish & Shellfish ImmunologyAuthor(s): Zhao Lv, Xiaorui Song, Jiachao Xu, Zhihao Jia, Bin Yang, Yunke Jia, Limei Qiu, Lingling Wang, Linsheng SongAbstractThe mitochondrial pathway of apoptosis is well studied as the major mechanism of physiological cell death in vertebrates. In the present study, a second mitochondria-derived activator of caspases (Smac)/direct inhibitor of apoptosis-binding protein (IAP) with low pI protein (DIABLO) (designated as CgSmac) was identified from oyster Crassostrea gigas. The open reading frame of CgSmac was of 966 bp nucleotides encoding a predicted polypeptide of 321 amino acids with a conserved Smac/DIABLO domain containing a potential IAP-binding motif of VMPV. CgSmac proteins were distributed in hem...

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