Healthy Meals: A Restaurant-based Study to Promote Healthy and Allergy Adapted Diet

Conditions:   Intervention;   Food Allergy;   Food Preferences;   Food Intolerance;   Diet Habit;   Diet Modification Intervention:   Behavioral: Multicomponent intervention Sponsors:   University Rovira i Virgili;   Diputació de Tarragona Not yet recruiting (Source: ClinicalTrials.gov)

MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2GsHcpZ

Non-Invasive Diagnosis of Pediatric Pulmonary Invasive Mold Infections

Conditions:   Pulmonary Invasive Mold Infections;   Pulmonary Invasive Aspergillosis Intervention:   Diagnostic Test: Non-Invasive Testing for PIMI Sponsors:   Duke University;   Children's Hospital of Philadelphia;   National Institute of Allergy and Infectious Diseases (NIAID) Recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SvtoBw

Allergy UK Research and Development Nurse Project

Condition:   Allergy Intervention:   Other: Nurse Led Allergy Clinic Sponsors:   University of Edinburgh;   Allergy UK Recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SsYRo6

Food Allergen Eliminations and Combined Protocols for Obesity Reduction: a Preliminary Comparison Study

Condition:   Obesity Intervention:   Behavioral: Food Allergy Elimination + Willis Exercise Sponsor:   Galveston Clinical Research Foundation Recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2StxSIZ

AQUApay (AQUA Predictive Ability in Youths): Study on the Predictive Ability of the Questionnaire AQUA © in Children and Adolescents

Condition:   Young Athletes Intervention:   Diagnostic Test: Questionnaire AQUA©, pediatric version Sponsor:   Istituto di Biomedicina e Immunologia Molecolare Alberto Monroy Not yet recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2GmJEyp

Diagnostic Equivalence of the Skin Prick Test Tape vs. Conventional Skin PrickTest

Conditions:   Allergic Rhinitis;   Allergic Asthma;   Allergic Conjunctivitis;   Food Allergy Interventions:   Diagnostic Test: Skin Prick Test;   Diagnostic Test: Skin Prick Test TAPE Sponsor:   Prof. Dr. Claus Bachert BVBA Not yet recruiting (Source: ClinicalTrials.gov)

MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SsYE4i

Blood Sampling of Healthy Volunteers for Immunological Research

Condition:   Healthy Volunteers Intervention:   Other: Blood sample Sponsor:   The Netherlands Cancer Institute Not yet recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2GrDKMw

Vaccination Coverage and Level of Protection in Patients at Risk

Conditions:   Diabetes;   Chronic Kidney Disease;   Allergy;   Cystic Fibrosis;   Heart Disease Intervention:   Sponsor:   Universitaire Ziekenhuizen Leuven Recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SsYycW

A Phase 1b Study of STMC-103H in Multi-Sensitized Allergic Subjects Who Are Otherwise Healthy

Condition:   Atopic Immunoglobulin E-Mediated Allergic Disorder Interventions:   Biological: STMC-103H;   Biological: Placebo Sponsors:   Siolta Therapeutics, Inc.;   Integrium Recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Gp8Hkq

Study to Evaluate the Efficacy and Safety of " Allergovac Poliplus " in Polysensitized Patients With Allergic Rhinitis/Rhinoconjunctivitis, With or Without Asthma

Conditions:   Rhinitis, Allergic;   Rhinoconjunctivitis Intervention:   Biological: Allergen Immunotherapy (AIT) Sponsor:   Roxall Medicina España S.A Recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SsY8mS

Healthy Meals: A Restaurant-based Study to Promote Healthy and Allergy Adapted Diet

Conditions:   Intervention;   Food Allergy;   Food Preferences;   Food Intolerance;   Diet Habit;   Diet Modification Intervention:   Behavioral: Multicomponent intervention Sponsors:   University Rovira i Virgili;   Diputació de Tarragona Not yet recruiting (Source: ClinicalTrials.gov)

MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2GsHcpZ

Non-Invasive Diagnosis of Pediatric Pulmonary Invasive Mold Infections

Conditions:   Pulmonary Invasive Mold Infections;   Pulmonary Invasive Aspergillosis Intervention:   Diagnostic Test: Non-Invasive Testing for PIMI Sponsors:   Duke University;   Children's Hospital of Philadelphia;   National Institute of Allergy and Infectious Diseases (NIAID) Recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SvtoBw

Retrospective Chart Review of Candida Fungemia

Condition:   Candida Intervention:   Sponsor:   National Institute of Allergy and Infectious Diseases (NIAID) Active, not recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Gp7rO5

Safety Study of Hepatitis E Vaccine (HEV239) in Healthy US Adult Population

Conditions:   Hepatitis E;   Immunisation Interventions:   Biological: HEV 239;   Other: Placebo Sponsor:   National Institute of Allergy and Infectious Diseases (NIAID) Not yet recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2GqwOza

Food Allergen Eliminations and Combined Protocols for Obesity Reduction: a Preliminary Comparison Study

Condition:   Obesity Intervention:   Behavioral: Food Allergy Elimination + Willis Exercise Sponsor:   Galveston Clinical Research Foundation Recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2StxSIZ

AQUApay (AQUA Predictive Ability in Youths): Study on the Predictive Ability of the Questionnaire AQUA © in Children and Adolescents

Condition:   Young Athletes Intervention:   Diagnostic Test: Questionnaire AQUA©, pediatric version Sponsor:   Istituto di Biomedicina e Immunologia Molecolare Alberto Monroy Not yet recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2GmJEyp

Diagnostic Equivalence of the Skin Prick Test Tape vs. Conventional Skin PrickTest

Conditions:   Allergic Rhinitis;   Allergic Asthma;   Allergic Conjunctivitis;   Food Allergy Interventions:   Diagnostic Test: Skin Prick Test;   Diagnostic Test: Skin Prick Test TAPE Sponsor:   Prof. Dr. Claus Bachert BVBA Not yet recruiting (Source: ClinicalTrials.gov)

MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SsYE4i

Blood Sampling of Healthy Volunteers for Immunological Research

Condition:   Healthy Volunteers Intervention:   Other: Blood sample Sponsor:   The Netherlands Cancer Institute Not yet recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2GrDKMw

Vaccination Coverage and Level of Protection in Patients at Risk

Conditions:   Diabetes;   Chronic Kidney Disease;   Allergy;   Cystic Fibrosis;   Heart Disease Intervention:   Sponsor:   Universitaire Ziekenhuizen Leuven Recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SsYycW

A Phase 1b Study of STMC-103H in Multi-Sensitized Allergic Subjects Who Are Otherwise Healthy

Condition:   Atopic Immunoglobulin E-Mediated Allergic Disorder Interventions:   Biological: STMC-103H;   Biological: Placebo Sponsors:   Siolta Therapeutics, Inc.;   Integrium Recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Gp8Hkq

Study to Evaluate the Efficacy and Safety of " Allergovac Poliplus " in Polysensitized Patients With Allergic Rhinitis/Rhinoconjunctivitis, With or Without Asthma

Conditions:   Rhinitis, Allergic;   Rhinoconjunctivitis Intervention:   Biological: Allergen Immunotherapy (AIT) Sponsor:   Roxall Medicina España S.A Recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SsY8mS

Unusual duplication and vulnerable intrapancreatic course of the left gastroepiploic artery: a rare anatomical variation

Abstract

The left gastroepiploic artery (LGEA) is the least described artery in the medical literature. Unusual variations of this artery might lead to vascular injuries, causing intraoperative bleeding after surgery. We observed rare vascular variations in an adult male cadaver. The left gastroepiploic artery after its origin from splenic artery pierced the pancreatic parenchyma at its posterior surface. After a short intrapancreatic course, the LGEA emerged out from the superior border of the body of the pancreas. LGEA then trifurcated into an omental branch, duplicated LGEA and another branch that continued as the main trunk of LGEA. Main LGEA and duplicated LGEA coursed towards the greater curvature of the stomach. The main LGEA ended by anastomosing with the right gastroepiploic artery, while the duplicated LGEA ended at the greater curvature of the stomach by ramifying into minute branches on the walls of the stomach and gave few gastric branches to supply the stomach and also supplied the greater omentum. This variation was associated with the presence of an accessory splenic artery. Anatomists, surgeons, and radiologists should be aware of such anomalous vascular variations as it could help to minimize complications related to pancreatectomy, omentoplasty, and resection of pancreatic tumors.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2TEwvoh

Unusual duplication and vulnerable intrapancreatic course of the left gastroepiploic artery: a rare anatomical variation

Abstract

The left gastroepiploic artery (LGEA) is the least described artery in the medical literature. Unusual variations of this artery might lead to vascular injuries, causing intraoperative bleeding after surgery. We observed rare vascular variations in an adult male cadaver. The left gastroepiploic artery after its origin from splenic artery pierced the pancreatic parenchyma at its posterior surface. After a short intrapancreatic course, the LGEA emerged out from the superior border of the body of the pancreas. LGEA then trifurcated into an omental branch, duplicated LGEA and another branch that continued as the main trunk of LGEA. Main LGEA and duplicated LGEA coursed towards the greater curvature of the stomach. The main LGEA ended by anastomosing with the right gastroepiploic artery, while the duplicated LGEA ended at the greater curvature of the stomach by ramifying into minute branches on the walls of the stomach and gave few gastric branches to supply the stomach and also supplied the greater omentum. This variation was associated with the presence of an accessory splenic artery. Anatomists, surgeons, and radiologists should be aware of such anomalous vascular variations as it could help to minimize complications related to pancreatectomy, omentoplasty, and resection of pancreatic tumors.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2TEwvoh

Paraspinal Muscle DTI Metrics Predict Muscle Strength

Background

The paraspinal muscles play an important role in the onset and progression of lower back pain. It would be of clinical interest to identify imaging biomarkers of the paraspinal musculature that are related to muscle function and strength. Diffusion tensor imaging (DTI) enables the microstructural examination of muscle tissue and its pathological changes.

Purpose

To investigate associations of DTI parameters of the lumbar paraspinal muscles with isometric strength measurements in healthy volunteers.

Study Type

Prospective.

Subjects

Twenty‐one healthy subjects (12 male, 9 female; age = 30.1 ± 5.6 years; body mass index [BMI] = 27.5 ± 2.6 kg/m²) were recruited.

Field Strength/Sequence

3 T/single‐shot echo planar imaging (ss‐EPI) DTI in 24 directions; six‐echo 3D spoiled gradient echo sequence for chemical shift encoding‐based water–fat separation.

Assessment

Paraspinal muscles at the lumbar spine were examined. Erector spinae muscles were segmented bilaterally; cross‐sectional area (CSA), proton density fat fraction (PDFF), and DTI parameters were calculated. Muscle flexion and extension maximum isometric torque values [Nm] at the back were measured with an isokinetic dynamometer and the ratio of extension to flexion strength (E/F) calculated.

Statistical Tests

Pearson correlation coefficients; multivariate regression models.

Results

Significant positive correlations were found between the ratio of extension to flexion (E/F) strength and mean diffusivity (MD) (P = 0.019), RD (P = 0.02) and the eigenvalues (λ1: P = 0.026, λ2: P = 0.033, λ3: P = 0.014). In multivariate regression models λ3 of the erector spinae muscle λ3 and gender remained statistically significant predictors of E/F (R²_adj = 0.42, P = 0.003).

Data Conclusion

DTI allowed the identification of muscle microstructure differences related to back muscle function that were not reflected by CSA and PDFF. DTI may potentially track subtle changes of back muscle tissue composition.

Level of Evidence: 3

Technical Efficacy: Stage 2

J. Magn. Reson. Imaging 2019.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2UInevu

Paraspinal Muscle DTI Metrics Predict Muscle Strength

Background

The paraspinal muscles play an important role in the onset and progression of lower back pain. It would be of clinical interest to identify imaging biomarkers of the paraspinal musculature that are related to muscle function and strength. Diffusion tensor imaging (DTI) enables the microstructural examination of muscle tissue and its pathological changes.

Purpose

To investigate associations of DTI parameters of the lumbar paraspinal muscles with isometric strength measurements in healthy volunteers.

Study Type

Prospective.

Subjects

Twenty‐one healthy subjects (12 male, 9 female; age = 30.1 ± 5.6 years; body mass index [BMI] = 27.5 ± 2.6 kg/m²) were recruited.

Field Strength/Sequence

3 T/single‐shot echo planar imaging (ss‐EPI) DTI in 24 directions; six‐echo 3D spoiled gradient echo sequence for chemical shift encoding‐based water–fat separation.

Assessment

Paraspinal muscles at the lumbar spine were examined. Erector spinae muscles were segmented bilaterally; cross‐sectional area (CSA), proton density fat fraction (PDFF), and DTI parameters were calculated. Muscle flexion and extension maximum isometric torque values [Nm] at the back were measured with an isokinetic dynamometer and the ratio of extension to flexion strength (E/F) calculated.

Statistical Tests

Pearson correlation coefficients; multivariate regression models.

Results

Significant positive correlations were found between the ratio of extension to flexion (E/F) strength and mean diffusivity (MD) (P = 0.019), RD (P = 0.02) and the eigenvalues (λ1: P = 0.026, λ2: P = 0.033, λ3: P = 0.014). In multivariate regression models λ3 of the erector spinae muscle λ3 and gender remained statistically significant predictors of E/F (R²_adj = 0.42, P = 0.003).

Data Conclusion

DTI allowed the identification of muscle microstructure differences related to back muscle function that were not reflected by CSA and PDFF. DTI may potentially track subtle changes of back muscle tissue composition.

Level of Evidence: 3

Technical Efficacy: Stage 2

J. Magn. Reson. Imaging 2019.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2UInevu

Symptom combos suggesting laryngeal cancer identified

Source: http://bit.ly/1ybXb1S Author: staff New symptom combinations that may indicate early symptoms of laryngeal cancer have been identified, according to a […]

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2WJIW44

Symptom combos suggesting laryngeal cancer identified

Source: http://bit.ly/1ybXb1S Author: staff New symptom combinations that may indicate early symptoms of laryngeal cancer have been identified, according to a […]

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2WJIW44

Symptom combos suggesting laryngeal cancer identified

Source: http://bit.ly/1ybXb1S Author: staff New symptom combinations that may indicate early symptoms of laryngeal cancer have been identified, according to a […]

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2WJIW44

Symptom combos suggesting laryngeal cancer identified

Source: http://bit.ly/1ybXb1S Author: staff New symptom combinations that may indicate early symptoms of laryngeal cancer have been identified, according to a […]

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2WJIW44

PTX3 and D‐dimer in children with asthma: a real‐world study‐Reply

Abstract

Licari and colleagues detected plasma pentraxin 3 (PTX3) and serum D‐dimer levels, and reported significant elevated concentrations for both biomarkers in asthmatic patients compared with healthy controls, but neither was observed to be associated with clinical parameters.

Elevated PTX3 expressions in asthmatic airways were firstly observed by Zhang et al,¹ and the same group reported that PTX3 deletion enhanced airway inflammation, mucus production, and airway hyperresponsiveness in an ovalbumin‐induced asthma model through a TH17‐dominant phenotype.²

This article is protected by copyright. All rights reserved.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2t4Kgkg

PTX3 and D‐dimer in children with asthma: a real‐world study‐Reply

Abstract

Licari and colleagues detected plasma pentraxin 3 (PTX3) and serum D‐dimer levels, and reported significant elevated concentrations for both biomarkers in asthmatic patients compared with healthy controls, but neither was observed to be associated with clinical parameters.

Elevated PTX3 expressions in asthmatic airways were firstly observed by Zhang et al,¹ and the same group reported that PTX3 deletion enhanced airway inflammation, mucus production, and airway hyperresponsiveness in an ovalbumin‐induced asthma model through a TH17‐dominant phenotype.²

This article is protected by copyright. All rights reserved.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2t4Kgkg

NK cells in treated HIV-infected children display altered phenotype and function

This is the first high-resolution NK cell phenotyping study in HIV-infected children that demonstrates an activation phenotype in NK cells despite anti-retroviral therapy. It also establishes an impact upon NK cells in both HIV-infected and exposed but uninfected children. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2BliXXE

Knowledge Gaps On Asthma Diagnosis Among General Physicians And Specialists In Contrast With Evidence-Based Clinical Guideline Recommendations: Results From A National Survey

This study sought to identify how knowledge concerning some aspects of asthma diagnosis may vary according to the treating physician's medical specialty. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2TAst06

The role of NADPH oxidase on the production of epithelial-derived cytokine (IL-25, IL-33, TSLP)

Airborne allergens stimulate the production of IL-25, IL-33 and TSLP from airway epithelial cells. However, the mechanism of allergen-induced cytokines production is not fully understood. The purpose of this study is to elucidate the role of oxidative stress, NADPH oxidase, on the allergen-induced production of epithelial-derived cytokines. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2BlefJm

Analysis of Alternative Thermal Processing Methods on Peanut Allergenicity Using Nuclear Magnetic Resonance (NMR) Spectroscopy

Peanut allergy is considered the most severe of all food allergies as it is the leading cause of fatal anaphylaxis. Evidence suggests that the allergenicity of peanuts is significantly increased in its roasted form when compared with raw. Our project aims to develop alternative processing methods to decrease the allergenicity of peanut. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Tuzdws

An Observed Serving Dose is Not Necessary Following a Standard Divided Dose FPIES Oral Food Challenge (OFC)

The method for an FPIES OFC is not standardized and reported approaches vary. We reviewed our experience with FPIES OFCs to evaluate whether an observed serving is necessary 2-3 hours following the initial divided dose OFC. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2BonLLJ

Respiratory Health Disparities Among Chicago Children

Children living in Chicago are disproportionately affected by respiratory health disease, especially asthma. Underlying social and environmental factors are to blame including barriers to access, knowledge, living conditions, and genetic predisposition. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2BlRdC2

Mixed cellular inflammation is increased in adult asthma with severe chronic rhinosinusitis

Chronic rhinosinusitis (CRS) is one of the important co-morbidities of asthma. Though sinus computed tomography (CT) image is widely used to evaluate CRS, the relationship between sinus CT findings and lower airway inflammation of asthma is not well defined. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2TxptRV

Diarrhea in an infant: food protein induced enterocolitis or very early onset inflammatory bowel disease

Food protein induced enterocolitis (FPIES) is a non-IgE mediated food allergy diagnosed in infants and toddlers presenting with severe vomiting and diarrhea leading to shock in 15% of cases. Consulting allergists should keep very-early onset inflammatory bowel disease (VEO-IBD), defined as IBD diagnosed in children 6 years of age or younger in the differential. IBD in this young age group tends to be more severe and is associated with immune dysregulation. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Bk3jvC

Importance of Peanuts ’ Lipophilic Proteins on Diagnosis of Allergic Disease

Peanut allergy usually occurs during the first years of life and most allergic children do not overcome it when they reach the adult stage. The prevalence varies from 1.2% to 2% in children and from 0.6% to 0.8% in adults. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Tyx0QH

Hizikia fusiformis Ameliorates Allergic Inflammation in an Ova-induced Allergic Rhinitis Mouse Model.

Recently, several studies have reported that extract of Hizikia fusiformis (HF) shows the immune-modulatory, anti-cancer, anti-atopic and anti-oxidant activities. The anti-inflammatory activity of HF suggests applications for diverse disorders including allergic and auto-immune, and sinonasal relative disease. We hypothesized that HF would alleviate the allergic rhinitis inflammation. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Bo91N0

Piecing Together the IgE-Reactivity Profile of Cannabis sativa in a North-Western European Region

The IgE-reactivity profile of cannabis remains incomplete and probably exhibits geographical variation. Both our own and other European data point to Can s 3, the non-specific lipid transfer protein (nsLTP) of cannabis as a major allergen. However, previous North-American research suggested other putative allergens such as Oxygen-Evolving-Enhancer Protein 2 (OEEP2). We aim at comparing the role of OEEP2 and Can s 3 in cannabis allergy in North-Western Europe. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2TA29D9

NK cells in treated HIV-infected children display altered phenotype and function

This is the first high-resolution NK cell phenotyping study in HIV-infected children that demonstrates an activation phenotype in NK cells despite anti-retroviral therapy. It also establishes an impact upon NK cells in both HIV-infected and exposed but uninfected children. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2BliXXE

New graft manipulation strategies improved outcome of mismatched stem cell transplantation in children with primary immunodeficiencies

Mismatched stem cell transplantation is associated with high risk of graft loss, graft versus host disease (GvHD) and transplant related mortality (TRM). Alternative graft manipulation strategies have been employed over the last 11 years to reduce these risks. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2BmQaln

Mast cells within cellular networks

Mast cells are highly versatile in terms of their mode of activation by a host of stimuli and their ability to flexibly release a plethora of biologically highly active mediators. Within the immune system, mast cells can best be designated as an active nexus interlinking innate and adaptive immunity. Herein, we try to draw an arc from the initiation of acute inflammatory reactions to microbial pathogens to the development of adaptive immunity and allergies. This multifaceted nature of mast cells is made possible by the interaction with multiple cell types of immunological and non-immunological origin. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2BkOs43

Siglec-8 Engagement Selectively Inhibits Allergen-Dependent Degranulation of Human Skin Mast Cells In Vitro

Mast cells (MCs) are well-known for their role in allergic responses. They can be activated through cross-linking of their high affinity IgE receptors (Fc εRI) by allergen, leading to the release of many pro-inflammatory mediators. Sialic acid-binding immunoglobulin-like (Siglec)-8 is a CD33-related receptor expressed on human MCs, though not yet described on skin MCs. A key feature of Siglec-8 is its inhibitory (ITIM) motif located within the cytopl asmic domain, suggesting that it may inhibit activating (ITAM) signaling. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2TAsxwS

Knowledge Gaps On Asthma Diagnosis Among General Physicians And Specialists In Contrast With Evidence-Based Clinical Guideline Recommendations: Results From A National Survey

This study sought to identify how knowledge concerning some aspects of asthma diagnosis may vary according to the treating physician's medical specialty. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2TAst06

Efficacy and Safety of Epicutaneous Immunotherapy for Peanut Allergy in Subjects With and Without Atopic Dermatitis

In the pooled Phase 3, randomized, double-blind, placebo-controlled trials (P3PCT), PEPITES and REALISE, peanut-allergic children aged 4-11 years were treated with daily epicutaneous immunotherapy (EPIT) with a 250- μg peanut patch (VP250) or placebo (PBO). PEPITES assessed EPIT safety and efficacy, while REALISE assessed EPIT safety without requiring food challenges. It is important to establish whether underlying skin disease affects the safety or efficacy profiles of EPIT. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2TAjYlq

Strong Dose-response On Immunoglobulin Makers During a Phase II Allergen Immunotherapy Study With Subcutaneously Administered Tyrosine Adsorbed Modified Grass Allergen + MPL

The results of this Phase II study [EudraCT 2017-000333-31] evaluated the dose response relationship for a modified grass allergen subcutaneous immunotherapy (SCIT) product (1.0 ml) with modified allergen tyrosine adsorbate (MATA) and monophosphoryl lipid A (MPL) adjuvants for the treatment of allergic rhinoconjunctivitis (ARC) due to grass pollen. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2BmQbFX

Analysis of Alternative Thermal Processing Methods on Peanut Allergenicity Using Nuclear Magnetic Resonance (NMR) Spectroscopy

Peanut allergy is considered the most severe of all food allergies as it is the leading cause of fatal anaphylaxis. Evidence suggests that the allergenicity of peanuts is significantly increased in its roasted form when compared with raw. Our project aims to develop alternative processing methods to decrease the allergenicity of peanut. (Source: Journal of Allergy and Clinical Immunology)

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An Observed Serving Dose is Not Necessary Following a Standard Divided Dose FPIES Oral Food Challenge (OFC)

The method for an FPIES OFC is not standardized and reported approaches vary. We reviewed our experience with FPIES OFCs to evaluate whether an observed serving is necessary 2-3 hours following the initial divided dose OFC. (Source: Journal of Allergy and Clinical Immunology)

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Mixed cellular inflammation is increased in adult asthma with severe chronic rhinosinusitis

Chronic rhinosinusitis (CRS) is one of the important co-morbidities of asthma. Though sinus computed tomography (CT) image is widely used to evaluate CRS, the relationship between sinus CT findings and lower airway inflammation of asthma is not well defined. (Source: Journal of Allergy and Clinical Immunology)

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Respiratory Health Disparities Among Chicago Children

Children living in Chicago are disproportionately affected by respiratory health disease, especially asthma. Underlying social and environmental factors are to blame including barriers to access, knowledge, living conditions, and genetic predisposition. (Source: Journal of Allergy and Clinical Immunology)

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Perceptions of a Continuing Medical Education Activity to Increase Knowledge of Vaccination in Adults with Chronic Inflammatory Conditions Among Clinicians

Patients with chronic inflammatory diseases are at increased risk for infections. Vaccination rates in this population are suboptimal. Vaccine knowledge among providers and patients is a significant barrier. (Source: Journal of Allergy and Clinical Immunology)

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Diarrhea in an infant: food protein induced enterocolitis or very early onset inflammatory bowel disease

Food protein induced enterocolitis (FPIES) is a non-IgE mediated food allergy diagnosed in infants and toddlers presenting with severe vomiting and diarrhea leading to shock in 15% of cases. Consulting allergists should keep very-early onset inflammatory bowel disease (VEO-IBD), defined as IBD diagnosed in children 6 years of age or younger in the differential. IBD in this young age group tends to be more severe and is associated with immune dysregulation. (Source: Journal of Allergy and Clinical Immunology)

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Importance of Peanuts ’ Lipophilic Proteins on Diagnosis of Allergic Disease

Peanut allergy usually occurs during the first years of life and most allergic children do not overcome it when they reach the adult stage. The prevalence varies from 1.2% to 2% in children and from 0.6% to 0.8% in adults. (Source: Journal of Allergy and Clinical Immunology)

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Hizikia fusiformis Ameliorates Allergic Inflammation in an Ova-induced Allergic Rhinitis Mouse Model.

Recently, several studies have reported that extract of Hizikia fusiformis (HF) shows the immune-modulatory, anti-cancer, anti-atopic and anti-oxidant activities. The anti-inflammatory activity of HF suggests applications for diverse disorders including allergic and auto-immune, and sinonasal relative disease. We hypothesized that HF would alleviate the allergic rhinitis inflammation. (Source: Journal of Allergy and Clinical Immunology)

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Piecing Together the IgE-Reactivity Profile of Cannabis sativa in a North-Western European Region

The IgE-reactivity profile of cannabis remains incomplete and probably exhibits geographical variation. Both our own and other European data point to Can s 3, the non-specific lipid transfer protein (nsLTP) of cannabis as a major allergen. However, previous North-American research suggested other putative allergens such as Oxygen-Evolving-Enhancer Protein 2 (OEEP2). We aim at comparing the role of OEEP2 and Can s 3 in cannabis allergy in North-Western Europe. (Source: Journal of Allergy and Clinical Immunology)

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Annual Meeting to Focus on Research

Registration opens in March for the 101st AAOMS Annual Meeting being held Sept. 16 to 21 in Boston, MA.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2DU7uj7

Annual Meeting to Focus on Research

Registration opens in March for the 101st AAOMS Annual Meeting being held Sept. 16 to 21 in Boston, MA.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2DU7uj7

Pilot Comparison of Adjustment Protocols of Personal Sound Amplification Products

Semin Hear 2019; 40: 026-036 DOI: 10.1055/s-0038-1676781The Over-the-Counter Hearing Aid Act of 2017 was signed into law in August 2017 and facilitates the introduction of direct-to-consumer sales of hearing aids for adults with mild-to-moderate hearing loss. Among many questions surrounding over-the-counter sales is the ability of users to self-fit amplification. Many studies have conducted self-fitting procedures using guidance materials provided by audiologists. In this pilot, we explore the ability of users to self-adjust personal sound amplification devices using only materials provided by the manufacturer and contrast this with models that involve a hearing professional. Outcomes to assess adjustments included clinic-based speech-in-noise measures and ability to approximate NAL-NL2 p...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2DUTupr

Evidence-Based Interventions for Adult Aural Rehabilitation: That Was Then, This Is Now

Semin Hear 2019; 40: 068-084 DOI: 10.1055/s-0038-1676784More than a decade after Arthur Boothroyd published "Adult Aural Rehabilitation: What Is It and Does It Work?," the four cornerstones of adult aural rehabilitation are re-examined in terms of research that we and others in the field have undertaken. The focus is on novel advances in high-quality research relating to interventions to support self-management for hearing aids and other listening devices (sensory management), knowledge and skill (instruction), auditory and cognitive training (perceptual training), and motivational engagement (counseling). Much of this new research has a theoretical underpinning (e.g., behavior change theory) to better guide the development and evaluation of interventions, with a focus on self-manageme...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Sts6XS

Pilot Comparison of Adjustment Protocols of Personal Sound Amplification Products

Semin Hear 2019; 40: 026-036 DOI: 10.1055/s-0038-1676781The Over-the-Counter Hearing Aid Act of 2017 was signed into law in August 2017 and facilitates the introduction of direct-to-consumer sales of hearing aids for adults with mild-to-moderate hearing loss. Among many questions surrounding over-the-counter sales is the ability of users to self-fit amplification. Many studies have conducted self-fitting procedures using guidance materials provided by audiologists. In this pilot, we explore the ability of users to self-adjust personal sound amplification devices using only materials provided by the manufacturer and contrast this with models that involve a hearing professional. Outcomes to assess adjustments included clinic-based speech-in-noise measures and ability to approximate NAL-NL2 p...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2DUTupr

Development and Formative Assessment of the Hearing Loss Toolkit for Self-Management

Semin Hear 2019; 40: 049-067 DOI: 10.1055/s-0038-1676783Hearing aids are a demonstrated efficacious intervention for age-related hearing loss, and research suggests that good hearing loss self-management skills improve amplification satisfaction and outcomes. One way to foster self-management skills is through the provision of patient education materials. However, many of the available resources related to the management of hearing loss do not account for health literacy and are not suitable for use with adults from varying health literacy backgrounds. To address this issue, we developed the Hearing Loss Toolkit for Self-Management as part of a manualized, best practices hearing intervention used in large clinical trial. We incorporated health literacy recommendations from the U.S. Departm...

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Novel Approaches to Fostering Hearing Loss Self-Management in Adults

Semin Hear 2019; 40: 003-006 DOI: 10.1055/s-0038-1677049 Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Hearing)

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Translating Public Health Practices: Community-Based Approaches for Addressing Hearing Health Care Disparities

Semin Hear 2019; 40: 037-048 DOI: 10.1055/s-0038-1676782Epidemiologic studies reveal disparities in hearing health care with lower prevalence of hearing aid use among older adults from racial/ethnic minority groups and lower socioeconomic positions. Recent national reports recommend exploring innovative delivery models to increase the accessibility and affordability of hearing health care, particularly for underserved and vulnerable populations. With an expected rise in the prevalence of age-related hearing loss over the next four decades due to a rapidly aging population, the condition is a growing public health imperative. This review describes key public health practices for developing and delivering community-based care that characterizes an emerging area of research in novel approache...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2DUXoia

The Chronic Care Model and Chronic Condition Self-Management: An Introduction for Audiologists

Semin Hear 2019; 40: 007-025 DOI: 10.1055/s-0038-1676780Hearing health care is biomedically focused, device-centered, and clinician-led. There is emerging evidence that these characteristics—all of which are hallmarks of a health care system designed to address acute, rather than chronic, conditions—may contribute to low rates of help-seeking and hearing rehabilitation uptake among adults with hearing loss. In this review, we introduce audiologists to the Chronic Care Model, an organizational framework that describes best-practice clinical care for chronic conditions, and suggest that it may be a viable model for hearing health care to adopt. We further introduce the concept of chronic condition self-management, a key component of chronic care that refers to the knowledge and skills pa...

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Important Information Regarding Continuing Education Units for Seminars in Hearing through AAA and ASHA

Semin Hear 2019; 40: 001-002 DOI: 10.1055/s-0038-1679869 Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Full text (Source: Seminars in Hearing)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2GqDyNx

Evidence-Based Interventions for Adult Aural Rehabilitation: That Was Then, This Is Now

Semin Hear 2019; 40: 068-084 DOI: 10.1055/s-0038-1676784More than a decade after Arthur Boothroyd published "Adult Aural Rehabilitation: What Is It and Does It Work?," the four cornerstones of adult aural rehabilitation are re-examined in terms of research that we and others in the field have undertaken. The focus is on novel advances in high-quality research relating to interventions to support self-management for hearing aids and other listening devices (sensory management), knowledge and skill (instruction), auditory and cognitive training (perceptual training), and motivational engagement (counseling). Much of this new research has a theoretical underpinning (e.g., behavior change theory) to better guide the development and evaluation of interventions, with a focus on self-manageme...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Sts6XS

Friendships and Self-Determination Among Students Who Are Deaf or Hard of Hearing.

Authors: Millen K, Dorn B, Luckner JL Abstract Friendships and self-determination are two factors that positively influence success in school and adult life. Examining the relationship between these two constructs among a sample of students who were deaf or hard of hearing (DHH), the researchers used the Self-Determination Inventory: Student Report (Shogren, Wehmeyer, Burke, & Palmer, 2017) to measure the level of self-determination of 29 students ages 13-17 years who were DHH. The researchers then used two self-report measures to probe students' quantity and quality of friendships, and conducted an analysis to determine whether the quality and quantity of friendships correlated with the self-determination of the students. Significant correlations were found between self-de...

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Perspectives of Deaf and Hard of Hearing Viewers of Captions.

Authors: Butler J Abstract Educational rights and other rights enumerated in federal law support deaf and hard of hearing (DHH) viewers' access to captions in visual electronic media, yet uncaptioned and inadequately captioned media still exist. To determine what is satisfactory in captioned media and what could be improved to ensure access, data were gathered from focus group discussions with 20 DHH students who shared their perspectives on captions. The focus group analysis indicates that major topics of concern for DHH viewers include advocacy for captions and caption formatting preferences; the need for direct access to real-time videos, online videos, and other media; how captions influence and benefit DHH and hearing viewers; and captions' importance in public, educational, a...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2DXbEah

Schooling Effects on Early Literacy Skills of Young Deaf and Hard of Hearing Children.

Authors: Scott JA, Goldberg H, Connor CM, Lederberg AR Abstract Already well documented for hearing children, schooling's effects on early literacy skills for young students who are deaf or hard of hearing (DHH) were examined for the first time in the present study. Piecewise growth curve modeling was used to describe 3-, 4-, and 5-year-old students' growth in phonological awareness, letter-word identification, and vocabulary during 2 years of schooling and the intervening summer (N = 56). Amplification mode was cochlear implants for 45% of the sample and hearing aids for 54%. Classroom communication mode was spoken language only (for 61%) or sign language (39%). Across all skills, significant growth occurred during the 2 years of schooling but not during the summer. These findings...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2MP4SpH

Teaching Academic Language to d/Deaf Students: Does Research Offer Evidence for Practice?

Authors: Strassman BK, Marashian K, Memon Z Abstract The authors culled evidence-based recommendations and guidelines for effective instruction from practice guides and national studies addressing the development of academic language in English Language Learners (ELLs). Working within the framework of the qualitative similarity hypothesis (Paul, Wang, & Williams, 2013), the authors used the evidence base from the ELL literature as a starting point for researching similar findings with d/Deaf students. The etic areas of academic talk, reading comprehension, vocabulary, writing, technology, teacher training, sheltered instruction, and small-group instruction are discussed. Given the parallels in findings (despite the lack of studies in d/Deaf education that meet the design st...

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Volume 163.

Authors: PMID: 30713201 [PubMed - in process] (Source: American Annals of the Deaf)

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2DWlskI

Translating Public Health Practices: Community-Based Approaches for Addressing Hearing Health Care Disparities

Semin Hear 2019; 40: 037-048 DOI: 10.1055/s-0038-1676782Epidemiologic studies reveal disparities in hearing health care with lower prevalence of hearing aid use among older adults from racial/ethnic minority groups and lower socioeconomic positions. Recent national reports recommend exploring innovative delivery models to increase the accessibility and affordability of hearing health care, particularly for underserved and vulnerable populations. With an expected rise in the prevalence of age-related hearing loss over the next four decades due to a rapidly aging population, the condition is a growing public health imperative. This review describes key public health practices for developing and delivering community-based care that characterizes an emerging area of research in novel approache...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2DUXoia

The Chronic Care Model and Chronic Condition Self-Management: An Introduction for Audiologists

Semin Hear 2019; 40: 007-025 DOI: 10.1055/s-0038-1676780Hearing health care is biomedically focused, device-centered, and clinician-led. There is emerging evidence that these characteristics—all of which are hallmarks of a health care system designed to address acute, rather than chronic, conditions—may contribute to low rates of help-seeking and hearing rehabilitation uptake among adults with hearing loss. In this review, we introduce audiologists to the Chronic Care Model, an organizational framework that describes best-practice clinical care for chronic conditions, and suggest that it may be a viable model for hearing health care to adopt. We further introduce the concept of chronic condition self-management, a key component of chronic care that refers to the knowledge and skills pa...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2MXTY1b

Pilot Comparison of Adjustment Protocols of Personal Sound Amplification Products

Semin Hear 2019; 40: 026-036 DOI: 10.1055/s-0038-1676781The Over-the-Counter Hearing Aid Act of 2017 was signed into law in August 2017 and facilitates the introduction of direct-to-consumer sales of hearing aids for adults with mild-to-moderate hearing loss. Among many questions surrounding over-the-counter sales is the ability of users to self-fit amplification. Many studies have conducted self-fitting procedures using guidance materials provided by audiologists. In this pilot, we explore the ability of users to self-adjust personal sound amplification devices using only materials provided by the manufacturer and contrast this with models that involve a hearing professional. Outcomes to assess adjustments included clinic-based speech-in-noise measures and ability to approximate NAL-NL2 p...

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2DUTupr

The value of four stage vestibular hydrops grading and asymmetric perilymphatic enhancement in the diagnosis of Meni ère’s disease on MRI

ConclusionsMRI using vestibular-cochlear EH and PE grading system is a reliable technique. A four-stage vestibular EH grading system in combination with cochlear PE assessment gives the best diagnostic accuracy to detect MD. (Source: Neuroradiology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2MQuAdA

Perspectives of Deaf and Hard of Hearing Viewers of Captions.

Authors: Butler J Abstract Educational rights and other rights enumerated in federal law support deaf and hard of hearing (DHH) viewers' access to captions in visual electronic media, yet uncaptioned and inadequately captioned media still exist. To determine what is satisfactory in captioned media and what could be improved to ensure access, data were gathered from focus group discussions with 20 DHH students who shared their perspectives on captions. The focus group analysis indicates that major topics of concern for DHH viewers include advocacy for captions and caption formatting preferences; the need for direct access to real-time videos, online videos, and other media; how captions influence and benefit DHH and hearing viewers; and captions' importance in public, educational, a...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2DXbEah

Schooling Effects on Early Literacy Skills of Young Deaf and Hard of Hearing Children.

Authors: Scott JA, Goldberg H, Connor CM, Lederberg AR Abstract Already well documented for hearing children, schooling's effects on early literacy skills for young students who are deaf or hard of hearing (DHH) were examined for the first time in the present study. Piecewise growth curve modeling was used to describe 3-, 4-, and 5-year-old students' growth in phonological awareness, letter-word identification, and vocabulary during 2 years of schooling and the intervening summer (N = 56). Amplification mode was cochlear implants for 45% of the sample and hearing aids for 54%. Classroom communication mode was spoken language only (for 61%) or sign language (39%). Across all skills, significant growth occurred during the 2 years of schooling but not during the summer. These findings...

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Deaf and Hard of Hearing Students' Understanding of Causal and Adversative Connectives in Sentence Reading.

Authors: Yan J, Li D Abstract Deaf and hard of hearing (DHH) students tend to experience delayed development of grammatical skills in written language. However, much remains unknown about the mechanism behind this phenomenon. In the present study, the researchers used a self-paced moving-window reading task to investigate DHH students' understanding of causal and adversative connectives in Chinese. The students were similar to a hearing control group in their comprehension of the relationship between the clauses in a causal sentence. However, the DHH students were more likely than their hearing peers to find it harder to understand adversative connectives than causal connectives. More studies are needed to reveal how DHH students deal with other syntactic structures that are partic...

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Volume 163.

Authors: PMID: 30713201 [PubMed - in process] (Source: American Annals of the Deaf)

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In Search of a Creative "Syncretizer": From Homo Sapiens Sapiens to Homo Techno Sapiens. . . . and Beyond.

In Search of a Creative "Syncretizer": From Homo Sapiens Sapiens to Homo Techno Sapiens. . . . and Beyond. Am Ann Deaf. 2019;163(5):495-500 Authors: Paul PV PMID: 30713195 [PubMed - in process] (Source: American Annals of the Deaf)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2MSvHcO

The Chronic Care Model and Chronic Condition Self-Management: An Introduction for Audiologists

Semin Hear 2019; 40: 007-025 DOI: 10.1055/s-0038-1676780Hearing health care is biomedically focused, device-centered, and clinician-led. There is emerging evidence that these characteristics—all of which are hallmarks of a health care system designed to address acute, rather than chronic, conditions—may contribute to low rates of help-seeking and hearing rehabilitation uptake among adults with hearing loss. In this review, we introduce audiologists to the Chronic Care Model, an organizational framework that describes best-practice clinical care for chronic conditions, and suggest that it may be a viable model for hearing health care to adopt. We further introduce the concept of chronic condition self-management, a key component of chronic care that refers to the knowledge and skills pa...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2MXTY1b

Pilot Comparison of Adjustment Protocols of Personal Sound Amplification Products

Semin Hear 2019; 40: 026-036 DOI: 10.1055/s-0038-1676781The Over-the-Counter Hearing Aid Act of 2017 was signed into law in August 2017 and facilitates the introduction of direct-to-consumer sales of hearing aids for adults with mild-to-moderate hearing loss. Among many questions surrounding over-the-counter sales is the ability of users to self-fit amplification. Many studies have conducted self-fitting procedures using guidance materials provided by audiologists. In this pilot, we explore the ability of users to self-adjust personal sound amplification devices using only materials provided by the manufacturer and contrast this with models that involve a hearing professional. Outcomes to assess adjustments included clinic-based speech-in-noise measures and ability to approximate NAL-NL2 p...

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2DUTupr

The value of four stage vestibular hydrops grading and asymmetric perilymphatic enhancement in the diagnosis of Meni ère’s disease on MRI

ConclusionsMRI using vestibular-cochlear EH and PE grading system is a reliable technique. A four-stage vestibular EH grading system in combination with cochlear PE assessment gives the best diagnostic accuracy to detect MD. (Source: Neuroradiology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2MQuAdA

Annual Meeting to Focus on Research

Registration opens in March for the 101st AAOMS Annual Meeting being held Sept. 16 to 21 in Boston, MA.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2DU7uj7

Annual Meeting to Focus on Research

Registration opens in March for the 101st AAOMS Annual Meeting being held Sept. 16 to 21 in Boston, MA.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2DU7uj7

Creating an Easier Path for Patients With Head/Neck Cancer

Recently, an article was published in the Leader about my work with patients with head or neck cancer. The response has been great, with the most-asked question being about the pathway I created to help patients and caregivers navigate through and receive improved access to care. How did I create this pathway? The first thing I did was listen to patients and caregivers discuss what they wished they knew before treatment started. After years of listening, I realized something had to change for them. From this realization came the idea of designing a pathway so all treating partners—as well as patients and caregivers—understood the process, what to expect and how to prepare for next steps. After deciding to create this process pathway and getting it approved by the hospital cancer board ...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Sdg45x

Creating an Easier Path for Patients With Head/Neck Cancer

Recently, an article was published in the Leader about my work with patients with head or neck cancer. The response has been great, with the most-asked question being about the pathway I created to help patients and caregivers navigate through and receive improved access to care. How did I create this pathway? The first thing I did was listen to patients and caregivers discuss what they wished they knew before treatment started. After years of listening, I realized something had to change for them. From this realization came the idea of designing a pathway so all treating partners—as well as patients and caregivers—understood the process, what to expect and how to prepare for next steps. After deciding to create this process pathway and getting it approved by the hospital cancer board ...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Sdg45x

Creating an Easier Path for Patients With Head/Neck Cancer

Recently, an article was published in the Leader about my work with patients with head or neck cancer. The response has been great, with the most-asked question being about the pathway I created to help patients and caregivers navigate through and receive improved access to care. How did I create this pathway? The first thing I did was listen to patients and caregivers discuss what they wished they knew before treatment started. After years of listening, I realized something had to change for them. From this realization came the idea of designing a pathway so all treating partners—as well as patients and caregivers—understood the process, what to expect and how to prepare for next steps. After deciding to create this process pathway and getting it approved by the hospital cancer board ...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Sdg45x

Creating an Easier Path for Patients With Head/Neck Cancer

Recently, an article was published in the Leader about my work with patients with head or neck cancer. The response has been great, with the most-asked question being about the pathway I created to help patients and caregivers navigate through and receive improved access to care. How did I create this pathway? The first thing I did was listen to patients and caregivers discuss what they wished they knew before treatment started. After years of listening, I realized something had to change for them. From this realization came the idea of designing a pathway so all treating partners—as well as patients and caregivers—understood the process, what to expect and how to prepare for next steps. After deciding to create this process pathway and getting it approved by the hospital cancer board ...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Sdg45x

Deaf moth evolves sound-production as a warning to outwit its predator

A genus of deaf moth has evolved to develop an extraordinary sound-producing structure in its wings to evade its primary predator the bat. The finding, made by researchers from the University of Bristol and Natural History Museum, is described in Scientific Reports today [Tuesday 5 February]. (Source: University of Bristol news)

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The vibrating universe: Making astronomy accessible to the deaf

(University of California - Riverside) Astronomers at the University of California, Riverside, have teamed with teachers at the California School for the Deaf, Riverside, or CSDR, to design an astronomy workshop for students with hearing loss that can be easily used in classrooms, museums, fairs, and other public events. The workshop utilized a sound stage that allowed the CSDR students to 'feel' vibrations from rockets, stars, galaxies, supernovae, and even remnants of the Big Bang itself. (Source: EurekAlert! - Medicine and Health)

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Deaf moth evolves sound-production as a warning to outwit its predator

A genus of deaf moth has evolved to develop an extraordinary sound-producing structure in its wings to evade its primary predator the bat. The finding, made by researchers from the University of Bristol and Natural History Museum, is described in Scientific Reports today [Tuesday 5 February]. (Source: University of Bristol news)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2TxezvB

The vibrating universe: Making astronomy accessible to the deaf

(University of California - Riverside) Astronomers at the University of California, Riverside, have teamed with teachers at the California School for the Deaf, Riverside, or CSDR, to design an astronomy workshop for students with hearing loss that can be easily used in classrooms, museums, fairs, and other public events. The workshop utilized a sound stage that allowed the CSDR students to 'feel' vibrations from rockets, stars, galaxies, supernovae, and even remnants of the Big Bang itself. (Source: EurekAlert! - Medicine and Health)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2BkxNxx

A Case of Castleman Disease with Recurrence in the Neck: Case Report and Literature Review

Castleman disease (CD) is a rare lymphoproliferative disorder with an uncertain etiology. It is necessary to review the known cases since it is easy to overlook the possibility of CD in clinical diagnosis.

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Outpatient Anesthesia Morbidity and Mortality Experience Among Massachusetts Oral & Maxillofacial Surgeons

The purpose of this retrospective study is to document the prevalence of different complications and the rate of mortality for outpatient procedures performed under anesthesia by oral and maxillofacial surgeons in the Commonwealth of Massachusetts.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Bmf58G

What is the Prevalence of Undiagnosed Nevoid Basal Cell Carcinoma Syndrome in Children with an Odontogenic Keratocyst?

Odontogenic keratocysts (OKC) can occur in isolation or as part of nevoid basal cell carcinoma syndrome (NBCCS). Subjects with NBCCS are younger at OKC diagnosis than those with non-syndromic OKC (NS-OKC). The purpose of this study was to determine the prevalence of undiagnosed NBCCS in children who present with an OKC and to assess differences in demographic and presenting features between children with NBCCS and those with NS-OKC.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2TwDteF

Surgery alone is effective in the management of pediatric salivary gland acinic cell carcinoma

The treatment strategy of salivary gland acinic cell carcinoma in pediatric patients remains controversial. This retrospective study was undertaken to analyze the role of surgery in the treatment of acinic cell carcinoma of the major salivary gland in pediatric patients.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2TuaLva

The Effect of Oral and Maxillofacial Surgery Residency Curriculum Design on USMLE Step 1 Performance

Over the years, a few types of combined OMS/MD residency curricula have evolved that differ in how the MD is integrated. The purpose of this study was to look for a difference in USMLE Step 1 pass rates among these different curricula.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2BjJJ2A

First case of cutaneous orbital abscess caused by Gemella: A case report and review of the literature

This is the first report of an orbital abscess caused by Gemella bergeri, uncommonly identified in cardiac valvular infections. Through MALDI-TOF MS (Matrix-Assisted Laser Desorption Ionization-time-of- flight Mass Spectrometry) microbial identification and speciation resulted in timely identification and appropriate management. Successful management includes accurate microbial identification, incision and drainage and broad spectrum antibiotics.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Tz73Am

A Case of Castleman Disease with Recurrence in the Neck: Case Report and Literature Review

Castleman disease (CD) is a rare lymphoproliferative disorder with an uncertain etiology. It is necessary to review the known cases since it is easy to overlook the possibility of CD in clinical diagnosis.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2BnfOX1

Outpatient Anesthesia Morbidity and Mortality Experience Among Massachusetts Oral & Maxillofacial Surgeons

The purpose of this retrospective study is to document the prevalence of different complications and the rate of mortality for outpatient procedures performed under anesthesia by oral and maxillofacial surgeons in the Commonwealth of Massachusetts.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Bmf58G

Sialadenitis May Be Associated with an Increased Risk for Osteoradionecrosis: A Nationwide Population-Based Cohort Study

The impact of sialadenitis on osteoradionecrosis is controversial. The aim of this study was to determine the association between sialadenitis and osteoradionecrosis.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Bng3kT

What is the Prevalence of Undiagnosed Nevoid Basal Cell Carcinoma Syndrome in Children with an Odontogenic Keratocyst?

Odontogenic keratocysts (OKC) can occur in isolation or as part of nevoid basal cell carcinoma syndrome (NBCCS). Subjects with NBCCS are younger at OKC diagnosis than those with non-syndromic OKC (NS-OKC). The purpose of this study was to determine the prevalence of undiagnosed NBCCS in children who present with an OKC and to assess differences in demographic and presenting features between children with NBCCS and those with NS-OKC.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2TwDteF

Surgery alone is effective in the management of pediatric salivary gland acinic cell carcinoma

The treatment strategy of salivary gland acinic cell carcinoma in pediatric patients remains controversial. This retrospective study was undertaken to analyze the role of surgery in the treatment of acinic cell carcinoma of the major salivary gland in pediatric patients.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2TuaLva

The Effect of Oral and Maxillofacial Surgery Residency Curriculum Design on USMLE Step 1 Performance

Over the years, a few types of combined OMS/MD residency curricula have evolved that differ in how the MD is integrated. The purpose of this study was to look for a difference in USMLE Step 1 pass rates among these different curricula.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2BjJJ2A

Is repeated arthrocentesis beneficial in the treatment of temporomandibular disorders: A retrospective study

Arthrocentesis is an effective, simple and minimally invasive treatment in patients with temporomandibular joint (TMJ) closed lock (CL). The aim of this study was to compare the effectiveness of one- or two-session arthrocentesis procedures in the management of TMJ-CL.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2TuaN6g

First case of cutaneous orbital abscess caused by Gemella: A case report and review of the literature

This is the first report of an orbital abscess caused by Gemella bergeri, uncommonly identified in cardiac valvular infections. Through MALDI-TOF MS (Matrix-Assisted Laser Desorption Ionization-time-of- flight Mass Spectrometry) microbial identification and speciation resulted in timely identification and appropriate management. Successful management includes accurate microbial identification, incision and drainage and broad spectrum antibiotics.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Tz73Am

NK cells in treated HIV-infected children display altered phenotype and function

This is the first high-resolution NK cell phenotyping study in HIV-infected children that demonstrates an activation phenotype in NK cells despite anti-retroviral therapy. It also establishes an impact upon NK cells in both HIV-infected and exposed but uninfected children.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Tz7U42

Report on Understanding the National Allergy Bureau as a Public Health Surveillance System

Public health surveillance includes the regular collection and use of data, such as aeroallergen data, to control disease. A standardized framework to describe public health surveillance systems exists but has not yet been used for aeroallergen data systems. We applied this framework to understand the National Allergy Bureau (NAB) as a public health surveillance system.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2BkyW8j

NK cells in treated HIV-infected children display altered phenotype and function

This is the first high-resolution NK cell phenotyping study in HIV-infected children that demonstrates an activation phenotype in NK cells despite anti-retroviral therapy. It also establishes an impact upon NK cells in both HIV-infected and exposed but uninfected children.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Tz7U42

Report on Understanding the National Allergy Bureau as a Public Health Surveillance System

Public health surveillance includes the regular collection and use of data, such as aeroallergen data, to control disease. A standardized framework to describe public health surveillance systems exists but has not yet been used for aeroallergen data systems. We applied this framework to understand the National Allergy Bureau (NAB) as a public health surveillance system.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2BkyW8j

Deaf moth evolves sound-production as a warning to outwit its predator

A genus of deaf moth has evolved to develop an extraordinary sound-producing structure in its wings to evade its primary predator the bat. The finding, made by researchers from the University of Bristol and Natural History Museum, is described in Scientific Reports today [Tuesday 5 February]. (Source: University of Bristol news)

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2TxezvB

The vibrating universe: Making astronomy accessible to the deaf

(University of California - Riverside) Astronomers at the University of California, Riverside, have teamed with teachers at the California School for the Deaf, Riverside, or CSDR, to design an astronomy workshop for students with hearing loss that can be easily used in classrooms, museums, fairs, and other public events. The workshop utilized a sound stage that allowed the CSDR students to 'feel' vibrations from rockets, stars, galaxies, supernovae, and even remnants of the Big Bang itself. (Source: EurekAlert! - Medicine and Health)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2BkxNxx

Deaf moth evolves sound-production as a warning to outwit its predator

A genus of deaf moth has evolved to develop an extraordinary sound-producing structure in its wings to evade its primary predator the bat. The finding, made by researchers from the University of Bristol and Natural History Museum, is described in Scientific Reports today [Tuesday 5 February]. (Source: University of Bristol news)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2TxezvB

The vibrating universe: Making astronomy accessible to the deaf

(University of California - Riverside) Astronomers at the University of California, Riverside, have teamed with teachers at the California School for the Deaf, Riverside, or CSDR, to design an astronomy workshop for students with hearing loss that can be easily used in classrooms, museums, fairs, and other public events. The workshop utilized a sound stage that allowed the CSDR students to 'feel' vibrations from rockets, stars, galaxies, supernovae, and even remnants of the Big Bang itself. (Source: EurekAlert! - Medicine and Health)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2BkxNxx

Outpatient Anesthesia Morbidity and Mortality Experience Among Massachusetts Oral & Maxillofacial Surgeons

The purpose of this retrospective study is to document the prevalence of different complications and the rate of mortality for outpatient procedures performed under anesthesia by oral and maxillofacial surgeons in the Commonwealth of Massachusetts.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Bmf58G

Sialadenitis May Be Associated with an Increased Risk for Osteoradionecrosis: A Nationwide Population-Based Cohort Study

The impact of sialadenitis on osteoradionecrosis is controversial. The aim of this study was to determine the association between sialadenitis and osteoradionecrosis.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Bng3kT

What is the Prevalence of Undiagnosed Nevoid Basal Cell Carcinoma Syndrome in Children with an Odontogenic Keratocyst?

Odontogenic keratocysts (OKC) can occur in isolation or as part of nevoid basal cell carcinoma syndrome (NBCCS). Subjects with NBCCS are younger at OKC diagnosis than those with non-syndromic OKC (NS-OKC). The purpose of this study was to determine the prevalence of undiagnosed NBCCS in children who present with an OKC and to assess differences in demographic and presenting features between children with NBCCS and those with NS-OKC.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2TwDteF

A Case of Castleman Disease with Recurrence in the Neck: Case Report and Literature Review

Castleman disease (CD) is a rare lymphoproliferative disorder with an uncertain etiology. It is necessary to review the known cases since it is easy to overlook the possibility of CD in clinical diagnosis.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2BnfOX1

First case of cutaneous orbital abscess caused by Gemella: A case report and review of the literature

This is the first report of an orbital abscess caused by Gemella bergeri, uncommonly identified in cardiac valvular infections. Through MALDI-TOF MS (Matrix-Assisted Laser Desorption Ionization-time-of- flight Mass Spectrometry) microbial identification and speciation resulted in timely identification and appropriate management. Successful management includes accurate microbial identification, incision and drainage and broad spectrum antibiotics.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Tz73Am

The Effect of Oral and Maxillofacial Surgery Residency Curriculum Design on USMLE Step 1 Performance

Over the years, a few types of combined OMS/MD residency curricula have evolved that differ in how the MD is integrated. The purpose of this study was to look for a difference in USMLE Step 1 pass rates among these different curricula.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2BjJJ2A

Is repeated arthrocentesis beneficial in the treatment of temporomandibular disorders: A retrospective study

Arthrocentesis is an effective, simple and minimally invasive treatment in patients with temporomandibular joint (TMJ) closed lock (CL). The aim of this study was to compare the effectiveness of one- or two-session arthrocentesis procedures in the management of TMJ-CL.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2TuaN6g

Outpatient Anesthesia Morbidity and Mortality Experience Among Massachusetts Oral & Maxillofacial Surgeons

The purpose of this retrospective study is to document the prevalence of different complications and the rate of mortality for outpatient procedures performed under anesthesia by oral and maxillofacial surgeons in the Commonwealth of Massachusetts.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Bmf58G

Surgery alone is effective in the management of pediatric salivary gland acinic cell carcinoma

The treatment strategy of salivary gland acinic cell carcinoma in pediatric patients remains controversial. This retrospective study was undertaken to analyze the role of surgery in the treatment of acinic cell carcinoma of the major salivary gland in pediatric patients.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2TuaLva

Sialadenitis May Be Associated with an Increased Risk for Osteoradionecrosis: A Nationwide Population-Based Cohort Study

The impact of sialadenitis on osteoradionecrosis is controversial. The aim of this study was to determine the association between sialadenitis and osteoradionecrosis.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Bng3kT

What is the Prevalence of Undiagnosed Nevoid Basal Cell Carcinoma Syndrome in Children with an Odontogenic Keratocyst?

Odontogenic keratocysts (OKC) can occur in isolation or as part of nevoid basal cell carcinoma syndrome (NBCCS). Subjects with NBCCS are younger at OKC diagnosis than those with non-syndromic OKC (NS-OKC). The purpose of this study was to determine the prevalence of undiagnosed NBCCS in children who present with an OKC and to assess differences in demographic and presenting features between children with NBCCS and those with NS-OKC.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2TwDteF

A Case of Castleman Disease with Recurrence in the Neck: Case Report and Literature Review

Castleman disease (CD) is a rare lymphoproliferative disorder with an uncertain etiology. It is necessary to review the known cases since it is easy to overlook the possibility of CD in clinical diagnosis.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2BnfOX1

The Effect of Oral and Maxillofacial Surgery Residency Curriculum Design on USMLE Step 1 Performance

Over the years, a few types of combined OMS/MD residency curricula have evolved that differ in how the MD is integrated. The purpose of this study was to look for a difference in USMLE Step 1 pass rates among these different curricula.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2BjJJ2A

Dad-of-two, 35, dies after being told he was too young to have throat cancer

Source: www.mirror.co.ukAuthor: Amber Hicks Ryan Greenan went to his doctor in Edinburgh in September after he started having trouble swallowing, eating and drinking. […]

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2t6NMKU

Dad-of-two, 35, dies after being told he was too young to have throat cancer

Source: www.mirror.co.ukAuthor: Amber Hicks Ryan Greenan went to his doctor in Edinburgh in September after he started having trouble swallowing, eating and drinking. […]

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2t6NMKU

GSK acquires rights to new Merck cancer treatment

UK group to pay up to €3.7bn to co-develop novel class of immunology (Source: FT.com - Drugs and Healthcare)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2MPr7vB

GSK acquires rights to new Merck cancer treatment

UK group to pay up to €3.7bn to co-develop novel class of immunology (Source: FT.com - Drugs and Healthcare)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2MPr7vB

GSK acquires rights to new Merck cancer treatment

UK group to pay up to €3.7bn to co-develop novel class of immunology (Source: FT.com - Drugs and Healthcare)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2MPr7vB

GSK acquires rights to new Merck cancer treatment

UK group to pay up to €3.7bn to co-develop novel class of immunology (Source: FT.com - Drugs and Healthcare)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2MPr7vB

Dad-of-two, 35, dies after being told he was too young to have throat cancer

Source: www.mirror.co.ukAuthor: Amber Hicks Ryan Greenan went to his doctor in Edinburgh in September after he started having trouble swallowing, eating and drinking. […]

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2t6NMKU

Dad-of-two, 35, dies after being told he was too young to have throat cancer

Source: www.mirror.co.ukAuthor: Amber Hicks Ryan Greenan went to his doctor in Edinburgh in September after he started having trouble swallowing, eating and drinking. […]

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2t6NMKU

March 27, 2019: Meeting of the Pulmonary-Allergy Drugs Advisory Committee Meeting Announcement

(Source: FDA Center for Drug Evaluation and Research - What's New)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2S9ufbC

Newborn Screening Identifies SCID and T-Cell Lymphopenia Newborn Screening Identifies SCID and T-Cell Lymphopenia

Newborn screening of DNA from dried blood spots identifies infants with severe combined immunodeficiency (SCID) and clinically important non-SCID T-cell lymphopenia, researchers report.Reuters Health Information (Source: Medscape Allergy Headlines)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2UJIjFx

March 27, 2019: Meeting of the Pulmonary-Allergy Drugs Advisory Committee Meeting Announcement

(Source: FDA Center for Drug Evaluation and Research - What's New)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2S9ufbC

Newborn Screening Identifies SCID and T-Cell Lymphopenia Newborn Screening Identifies SCID and T-Cell Lymphopenia

Newborn screening of DNA from dried blood spots identifies infants with severe combined immunodeficiency (SCID) and clinically important non-SCID T-cell lymphopenia, researchers report.Reuters Health Information (Source: Medscape Allergy Headlines)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2UJIjFx

Quality of life after microvascular mandibular reconstruction for osteoradionecrosis—A prospective study

Abstract

Background

Reconstructive surgery for mandibular osteoradionecrosis is increasing; however, evidence regarding the impact on health‐related quality of life is lacking. The current exploratory study prospectively investigates whether resection with reconstruction is associated with changes in HRQoL parameters for these patients.

Methods

Seventeen patients underwent microvascular reconstruction for mandibular osteoradionecrosis between 2012 and 2015, and 16 completed the EORTC quality of life questionnaires QLQ‐C30 and QLQ‐H&N35 1 month before and 1 year after surgery.

Results

Increases in emotional (P = 0.01) and social functioning (P = 0.004) were observed, together with improvements in the fatigue (P = 0.04), appetite loss (P = 0.02) and pain (P = 0.02) scores, as evaluated by the QLQ‐C30. Pain reduction was further confirmed by the QLQ‐H&N35 (P = 0.04), which also showed improved scores for feeling ill (P = 0.001) and sexual difficulties (P = 0.04).

Conclusion

This exploratory study suggests that microvascular reconstruction after mandibular osteoradionecrosis may improve HRQoL, with an emphasis on pain reduction; however, further studies are needed.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Gr5wJ4

Quality of life after microvascular mandibular reconstruction for osteoradionecrosis—A prospective study

Abstract

Background

Reconstructive surgery for mandibular osteoradionecrosis is increasing; however, evidence regarding the impact on health‐related quality of life is lacking. The current exploratory study prospectively investigates whether resection with reconstruction is associated with changes in HRQoL parameters for these patients.

Methods

Seventeen patients underwent microvascular reconstruction for mandibular osteoradionecrosis between 2012 and 2015, and 16 completed the EORTC quality of life questionnaires QLQ‐C30 and QLQ‐H&N35 1 month before and 1 year after surgery.

Results

Increases in emotional (P = 0.01) and social functioning (P = 0.004) were observed, together with improvements in the fatigue (P = 0.04), appetite loss (P = 0.02) and pain (P = 0.02) scores, as evaluated by the QLQ‐C30. Pain reduction was further confirmed by the QLQ‐H&N35 (P = 0.04), which also showed improved scores for feeling ill (P = 0.001) and sexual difficulties (P = 0.04).

Conclusion

This exploratory study suggests that microvascular reconstruction after mandibular osteoradionecrosis may improve HRQoL, with an emphasis on pain reduction; however, further studies are needed.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Gr5wJ4

March 27, 2019: Meeting of the Pulmonary-Allergy Drugs Advisory Committee Meeting Announcement

(Source: FDA Center for Drug Evaluation and Research - What's New)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2S9ufbC

Newborn Screening Identifies SCID and T-Cell Lymphopenia Newborn Screening Identifies SCID and T-Cell Lymphopenia

Newborn screening of DNA from dried blood spots identifies infants with severe combined immunodeficiency (SCID) and clinically important non-SCID T-cell lymphopenia, researchers report.Reuters Health Information (Source: Medscape Allergy Headlines)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2UJIjFx

Newborn Screening Identifies SCID and T-Cell Lymphopenia Newborn Screening Identifies SCID and T-Cell Lymphopenia

Newborn screening of DNA from dried blood spots identifies infants with severe combined immunodeficiency (SCID) and clinically important non-SCID T-cell lymphopenia, researchers report.Reuters Health Information (Source: Medscape Allergy Headlines)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2UJIjFx

CC Grand Rounds: 1) Severe Combined Immune Deficiency in the Newborn Screening Era: Genetic Landscape and Current Challenges and 2) Update on Clinical Outcome of Gene Therapy for X-linked Severe Combined Immune Deficiency

Date: Wednesday, 02 27, 2019; Speaker: Luigi Notarangelo, MD, Head, Immune Deficiency Genetics , Section and Chief, Laboratory of Clinical Immunology and Microbiology, , NIAID; Harry Malech, MD, Chief, Genetic Immunotherapy Section, , and Deputy Chief, Laboratory of Clinical Immunology and Microbiology, , NIAID; Building: Building 10 (Clinical Center); Lipsett Amphitheater; CME Credit; Videocast Event (Source: NIH Calendar of Events)

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2HSpEpz

Clinicopathologic Grand Rounds: Clinical Cases from the NIH Clinical Center Fungi Going Wild in the Central Nervous Syndrome (CNS): The Role of C-type Lectin Receptor Signaling

Date: Wednesday, 02 20, 2019; Speaker: Elise M. N. Ferre, PA-C, MPH Physician Assistant; , Laboratory of Clinical Immunology and Microbiology, , NIAID; Prashant Chittiboina, MD, Assistant Clinical Investigator, , Neurosurgery Unit for Pituitary and Inheritable Diseases, , NINDS; Michail S. Lionakis, MD, ScD, Chief, Fungal Pathogenesis Section; , Deputy Chief, Laboratory of Clinical Immunology , and Microbiology, NIAID; Building: Building 10 (Clinical Center); Lipsett Amphitheater; CME Credit; Videocast Event (Source: NIH Calendar of Events)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2t4AUoC

CC Grand Rounds: 1) Severe Combined Immune Deficiency in the Newborn Screening Era: Genetic Landscape and Current Challenges and 2) Update on Clinical Outcome of Gene Therapy for X-linked Severe Combined Immune Deficiency

Date: Wednesday, 02 27, 2019; Speaker: Luigi Notarangelo, MD, Head, Immune Deficiency Genetics , Section and Chief, Laboratory of Clinical Immunology and Microbiology, , NIAID; Harry Malech, MD, Chief, Genetic Immunotherapy Section, , and Deputy Chief, Laboratory of Clinical Immunology and Microbiology, , NIAID; Building: Building 10 (Clinical Center); Lipsett Amphitheater; CME Credit; Videocast Event (Source: NIH Calendar of Events)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2HSpEpz

Clinicopathologic Grand Rounds: Clinical Cases from the NIH Clinical Center Fungi Going Wild in the Central Nervous Syndrome (CNS): The Role of C-type Lectin Receptor Signaling

Date: Wednesday, 02 20, 2019; Speaker: Elise M. N. Ferre, PA-C, MPH Physician Assistant; , Laboratory of Clinical Immunology and Microbiology, , NIAID; Prashant Chittiboina, MD, Assistant Clinical Investigator, , Neurosurgery Unit for Pituitary and Inheritable Diseases, , NINDS; Michail S. Lionakis, MD, ScD, Chief, Fungal Pathogenesis Section; , Deputy Chief, Laboratory of Clinical Immunology , and Microbiology, NIAID; Building: Building 10 (Clinical Center); Lipsett Amphitheater; CME Credit; Videocast Event (Source: NIH Calendar of Events)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2t4AUoC

Evaluating the Predicted Impact of Changes to the AJCC/TMN Staging System for Differentiated Thyroid Cancer (DTC): A prospective observational study of patients in South East Scotland

Abstract

Objectives To assess the impact of the eighth edition AJCC/TMN staging system on patients with new diagnoses of differentiated thyroid cancers presenting to our regional multi‐disciplinary team meetings. Design We analysed Endocrine Cancer MDT meeting records from 2009‐2015 to identify all patients in the region presenting with a new diagnosis of differentiated thyroid cancer. We re‐staged patients according to the eighth edition AJCC/TNM staging classification and analysed the survival outcomes of patients in each stage under the seventh and eighth systems. Setting Tertiary referral centre in South East Scotland (NHS Lothian). Participants Three hundred and sixty one patients were newly diagnosed with DTC within South East Scotland during the study period and met our inclusion criteria. Main outcome measures Mortality at any time during follow‐up Results In total 119/361 (33%) patients were re‐staged when the eighth edition AJCC/TMN system was applied. The number of patients classified as having advanced stage (III/IV) disease fell from 76 (21%) to 8 (2%). The most common reason for down‐staging was re‐classification of tumour size, a factor in 96 (80.7%) down‐staged patients. The five‐year disease specific survival of the cohort overall was 98%. Overall 7 (1.9%) thyroid cancer –related deaths occurred during follow‐up, three of whom were down‐staged. Conclusions On implementation of the eighth edition of the AJCC/TMN staging system, we expect many patients who would previously have been considered to have advanced thyroid cancer will now be classified as early stage. This will accurately reflect their excellent survival outcomes.

This article is protected by copyright. All rights reserved.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2MPiW2w

Cost‐effectiveness of trans‐nasal endoscopic sphenopalatine artery ligation vs. arterial embolisation for intractable epistaxis: long‐term analyses

Summary

Objectives

Trans‐nasal endoscopic sphenopalatine artery ligation (TESPAL) and endovascular arterial embolisation both provide excellent success rates for intractable epistaxis. Recent economic models suggest that TESPAL could be a cost‐saving strategy. Our main aim was to perform cost‐effectiveness analyses on TESPAL compared to embolisation to treat patients with epistaxis.

Design

We performed a retrospective, monocentric, comparative analyses on patients referred to our center and treated with embolisation or TESPAL.

Setting

This economic evaluation was carried out from a payer's perspective (i.e., French National Health Insurance) within a time horizon of 12 months.

Participants

Thirty‐seven TESPAL procedures and thirty‐nine embolisation procedures to treat intractable epistaxis were used in the analyses.

Main outcome measures

The primary outcome is presented as the cost per 1% of non‐recurrence. Effectiveness was defined as avoiding recurrence of epistaxis during the 1‐year follow‐up. Cost estimates were performed from the payer's perspective.

Results

Hospitalisation costs were higher for embolisation compared to TESPAL (5,972 vs. 3,769 euros). On average, hospitalization costs decreased by 41% when a patient was treated by TESPAL compared to an embolisation strategy (p= 0.06). The presence of comorbidities increased hospitalization costs by 79% (p=0.04). TESPAL enabled 1,867€ to be gained in intractable epistaxis.

Conclusions

The outcomes from our decision model confirm that TESPAL is more cost‐effective for patients with intractable epistaxis.

This article is protected by copyright. All rights reserved.

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Evaluating the Predicted Impact of Changes to the AJCC/TMN Staging System for Differentiated Thyroid Cancer (DTC): A prospective observational study of patients in South East Scotland

Abstract

Objectives To assess the impact of the eighth edition AJCC/TMN staging system on patients with new diagnoses of differentiated thyroid cancers presenting to our regional multi‐disciplinary team meetings. Design We analysed Endocrine Cancer MDT meeting records from 2009‐2015 to identify all patients in the region presenting with a new diagnosis of differentiated thyroid cancer. We re‐staged patients according to the eighth edition AJCC/TNM staging classification and analysed the survival outcomes of patients in each stage under the seventh and eighth systems. Setting Tertiary referral centre in South East Scotland (NHS Lothian). Participants Three hundred and sixty one patients were newly diagnosed with DTC within South East Scotland during the study period and met our inclusion criteria. Main outcome measures Mortality at any time during follow‐up Results In total 119/361 (33%) patients were re‐staged when the eighth edition AJCC/TMN system was applied. The number of patients classified as having advanced stage (III/IV) disease fell from 76 (21%) to 8 (2%). The most common reason for down‐staging was re‐classification of tumour size, a factor in 96 (80.7%) down‐staged patients. The five‐year disease specific survival of the cohort overall was 98%. Overall 7 (1.9%) thyroid cancer –related deaths occurred during follow‐up, three of whom were down‐staged. Conclusions On implementation of the eighth edition of the AJCC/TMN staging system, we expect many patients who would previously have been considered to have advanced thyroid cancer will now be classified as early stage. This will accurately reflect their excellent survival outcomes.

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Cost‐effectiveness of trans‐nasal endoscopic sphenopalatine artery ligation vs. arterial embolisation for intractable epistaxis: long‐term analyses

Summary

Objectives

Trans‐nasal endoscopic sphenopalatine artery ligation (TESPAL) and endovascular arterial embolisation both provide excellent success rates for intractable epistaxis. Recent economic models suggest that TESPAL could be a cost‐saving strategy. Our main aim was to perform cost‐effectiveness analyses on TESPAL compared to embolisation to treat patients with epistaxis.

Design

We performed a retrospective, monocentric, comparative analyses on patients referred to our center and treated with embolisation or TESPAL.

Setting

This economic evaluation was carried out from a payer's perspective (i.e., French National Health Insurance) within a time horizon of 12 months.

Participants

Thirty‐seven TESPAL procedures and thirty‐nine embolisation procedures to treat intractable epistaxis were used in the analyses.

Main outcome measures

The primary outcome is presented as the cost per 1% of non‐recurrence. Effectiveness was defined as avoiding recurrence of epistaxis during the 1‐year follow‐up. Cost estimates were performed from the payer's perspective.

Results

Hospitalisation costs were higher for embolisation compared to TESPAL (5,972 vs. 3,769 euros). On average, hospitalization costs decreased by 41% when a patient was treated by TESPAL compared to an embolisation strategy (p= 0.06). The presence of comorbidities increased hospitalization costs by 79% (p=0.04). TESPAL enabled 1,867€ to be gained in intractable epistaxis.

Conclusions

The outcomes from our decision model confirm that TESPAL is more cost‐effective for patients with intractable epistaxis.

This article is protected by copyright. All rights reserved.

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Intensification of the O3/TIO2/UV advanced oxidation process using a modified flotation cell

Photochem. Photobiol. Sci., 2019, Accepted Manuscript
DOI: 10.1039/C8PP00308D, Paper

Jose Antonio Lara-Ramos, Katerine Sánchez Gómez, Daniel Alejandro Valencia-Rincon, Jennyfer Diaz, Miguel Angel Mueses , Fiderman Machuca-Martínez
The present work reports the use of a flotation cell as a prospective reactor for ozonation and the intensification of ozonation (catalytic ozonation and photocatalytic ozonation). The effect of pH,...
The content of this RSS Feed (c) The Royal Society of Chemistry

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UVR8-dependent reporters reveal spatial characteristics of signal spreading in plant tissues

Photochem. Photobiol. Sci., 2019, Accepted Manuscript
DOI: 10.1039/C8PP00492G, Paper

Lucas Vanhaelewyn, Peter Bernula, Dominique Van Der Straeten, Filip Vandenbussche, András Viczián
The UV RESISTANCE LOCUS 8 (UVR8) photoreceptor controls UV-B mediated photomorphogenesis in Arabidopsis. The aim of this work is to collect and characterize different molecular reporters of photomorphogenic UV-B responses....
The content of this RSS Feed (c) The Royal Society of Chemistry

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Intensification of the O3/TIO2/UV advanced oxidation process using a modified flotation cell

Photochem. Photobiol. Sci., 2019, Accepted Manuscript
DOI: 10.1039/C8PP00308D, Paper

Jose Antonio Lara-Ramos, Katerine Sánchez Gómez, Daniel Alejandro Valencia-Rincon, Jennyfer Diaz, Miguel Angel Mueses , Fiderman Machuca-Martínez
The present work reports the use of a flotation cell as a prospective reactor for ozonation and the intensification of ozonation (catalytic ozonation and photocatalytic ozonation). The effect of pH,...
The content of this RSS Feed (c) The Royal Society of Chemistry

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://rsc.li/2I35PvI

UVR8-dependent reporters reveal spatial characteristics of signal spreading in plant tissues

Photochem. Photobiol. Sci., 2019, Accepted Manuscript
DOI: 10.1039/C8PP00492G, Paper

Lucas Vanhaelewyn, Peter Bernula, Dominique Van Der Straeten, Filip Vandenbussche, András Viczián
The UV RESISTANCE LOCUS 8 (UVR8) photoreceptor controls UV-B mediated photomorphogenesis in Arabidopsis. The aim of this work is to collect and characterize different molecular reporters of photomorphogenic UV-B responses....
The content of this RSS Feed (c) The Royal Society of Chemistry

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://rsc.li/2t6Rogb

The difference in nasal bacterial microbiome diversity between chronic rhinosinusitis patients with polyps and a control population

Background

Little is known regarding the role of the microbiome of the paranasal sinuses and its contribution to sinus mucosal health and disease. Consequently, we examined the microbiome of chronic rhinosinusitis patients with polyps (CRSwNP) and a control population to provide new insights into the microbiota associated with the pathogenesis of CRSwNP.

Methods

Fifty‐nine CRSwNP patients and 27 controls were enrolled in the study. The bacterial communities of the middle meatus were detected using 16S ribosomal RNA (rRNA)‒targeted Illumina MiSeq sequencing after microbial DNA was extracted from swabs.

Results

Although there was no difference in diversity between the 2 groups, richness was lower in the CRSwNP group than in the control group (p = 0.03). At the phylum level, Firmicutes, Proteobacteria, Actinobacteria, and Bacteroidetes were predominant in both groups; however, the relative abundance was different, with the proportions of Actinobacteria (predominantly Corynebacterium) and Dolosigranulum being significantly higher in the control group than in the CRSwNP group.

Conclusion

These results support the theory of microbial dysbiosis as the pathogenesis of CRSwNP. The reduction in the proportions of potentially protective bacteria may decrease the overall stability of the sinonasal bacterial community.

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An analysis of factors associated with compliance and dropout of sublingual immunotherapy on Japanese cedar pollinosis patients

Background

Sublingual immunotherapy (SLIT) is safe and effective but compliance is problematic. In this study we evaluated dropout and compliance among adults (≥20 years of age) and adolescents (<20 years of age) for Japanese cedar pollen extract (JCPE), an aqueous SLIT approved in 2014 in Japan.

Methods

Administrative claims data on 1236 Japanese patients, 846 adults (mean age, 43.0 years; 41.8% female) and 249 adolescents (mean age, 14.1 years; 36.6% female), with a JCPE prescription between October 2014 and June 2016 were reviewed. Adults and adolescents were divided according to the year they started SLIT (1‐ and 2‐year cohorts) to calculate dropout and compliance and identify associated factors using multivariate Cox and linear regression models.

Results

In 1‐ and 2‐year adult cohorts, dropout rates were 13.5% and 22.1% and compliance rates were 92.8% and 88.8%, respectively. Adolescents had higher dropout and lower compliance. Patients 40‐59 years of age had a lower dropout risk than patients 20‐29 years of age. Dropout hazard ratios (95% confidence interval) in 1‐ and 2‐year cohorts were 0.26 (0.12‐0.58) and 0.40 (0.17‐0.93) in patients 40‐49 years of age and 0.32 (0.14‐0.75) and 0.35 (0.13‐0.92) in patients 50‐59 years of age, respectively. Younger age contributed to lower compliance in 1‐ and 2‐year adult cohorts (p = 0.001 and p = 0.02, respectively). Systemic steroidal medication history and male gender were positively associated with compliance in adults but not in adolescents.

Conclusion

High dropout rate was associated with younger generations. Compliance in adults, but not in adolescents, was associated with age, systemic steroidal medication history, and gender.

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