Abstract: Chronic lymphoproliferative disorder of natural killer cells (CLPDNK) is a rare heterogenous indolent disorder comprising a persistent peripheral blood cell count of more than ≥2 × 109/L natural killer cells for over 6 months. We report an unusual case of cutaneous neural infiltration as a manifestation of CLPDNK. A 52-year-old woman with a background of CLPDNK was referred to dermatology with a painful rash primarily affecting her back. Skin biopsies revealed a neurotropic atypical lymphoid infiltration. Results of immunohistochemistry studies showed CD8, CD56, granzyme B, perforin positivity, and CD3 negativity in keeping with an atypical neurotropic lymphoid infiltrate consistent with cutaneous involvement by the patient's known CLPDNK. Cutaneous lesions and peripheral neuropathy in patients with CLPDNK have been reported; however, the involvement of cutaneous peripheral nerves as described in our case has not been reported before. Correspondence: Sarah Ní Mhaolcatha, Department of Pathology, Cork University Hospital, Cork, Ireland (e-mail: Sarah.Nimhaolcatha@hse.ie). The authors declare no conflicts of interest. Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.
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Κυριακή 28 Οκτωβρίου 2018
A Granular Cell Tumor Appearing at a Vaccination Site, a Possible Reaction to Trauma?
Syringotropic Lichen Planus: A Potential Histopathologic Mimicker of Syringotropic Mycosis Fungoides
Abstract: Perieccrine inflammation may be observed in several different dermatoses, but true permeation of the secretory coil by lymphocytes (lymphocytic syringotropism) is a rather uncommon finding, usually observed in mycosis fungoides (MF—syringotropic MF). Rare cases of syringotropic lichen striatus and lymphocytic autoimmune hidradenitis showing a similar pattern have been described as well. We describe an exceptional case of lichen planus (LP) characterized by marked lymphocytic syringotropism with focal hyperplasia of the eccrine epithelium. Histopathology was characterized by the combination of features of conventional LP, prominent permeation of the secretory portion of the eccrine glands by reactive lymphocytes, and focal involvement of a hair follicle. Syringotropic LP may be regarded as a histologic mimicker of syringotropic MF, thus representing a potential diagnostic pitfall. Correspondence: Lorenzo Cerroni, MD, Department of Dermatology, Medical University of Graz, Auenbruggerplatz 8, A-8036 Graz, Austria (e-mail: lorenzo.cerroni@medunigraz.at). The authors declare no conflicts of interest. Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.
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Violaceous Plaques and Nodules: Challenge
A Stab in the Back: An Unusual Case of Cutaneous Neural Infiltration as a Manifestation of Chronic Lymphoproliferative Disorder of Natural Killer Cells
Abstract: Chronic lymphoproliferative disorder of natural killer cells (CLPDNK) is a rare heterogenous indolent disorder comprising a persistent peripheral blood cell count of more than ≥2 × 109/L natural killer cells for over 6 months. We report an unusual case of cutaneous neural infiltration as a manifestation of CLPDNK. A 52-year-old woman with a background of CLPDNK was referred to dermatology with a painful rash primarily affecting her back. Skin biopsies revealed a neurotropic atypical lymphoid infiltration. Results of immunohistochemistry studies showed CD8, CD56, granzyme B, perforin positivity, and CD3 negativity in keeping with an atypical neurotropic lymphoid infiltrate consistent with cutaneous involvement by the patient's known CLPDNK. Cutaneous lesions and peripheral neuropathy in patients with CLPDNK have been reported; however, the involvement of cutaneous peripheral nerves as described in our case has not been reported before. Correspondence: Sarah Ní Mhaolcatha, Department of Pathology, Cork University Hospital, Cork, Ireland (e-mail: Sarah.Nimhaolcatha@hse.ie). The authors declare no conflicts of interest. Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.
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A Granular Cell Tumor Appearing at a Vaccination Site, a Possible Reaction to Trauma?
Syringotropic Lichen Planus: A Potential Histopathologic Mimicker of Syringotropic Mycosis Fungoides
Abstract: Perieccrine inflammation may be observed in several different dermatoses, but true permeation of the secretory coil by lymphocytes (lymphocytic syringotropism) is a rather uncommon finding, usually observed in mycosis fungoides (MF—syringotropic MF). Rare cases of syringotropic lichen striatus and lymphocytic autoimmune hidradenitis showing a similar pattern have been described as well. We describe an exceptional case of lichen planus (LP) characterized by marked lymphocytic syringotropism with focal hyperplasia of the eccrine epithelium. Histopathology was characterized by the combination of features of conventional LP, prominent permeation of the secretory portion of the eccrine glands by reactive lymphocytes, and focal involvement of a hair follicle. Syringotropic LP may be regarded as a histologic mimicker of syringotropic MF, thus representing a potential diagnostic pitfall. Correspondence: Lorenzo Cerroni, MD, Department of Dermatology, Medical University of Graz, Auenbruggerplatz 8, A-8036 Graz, Austria (e-mail: lorenzo.cerroni@medunigraz.at). The authors declare no conflicts of interest. Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.
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Violaceous Plaques and Nodules: Challenge
Improvement of exertional dyspnea and breathing pattern of inspiration to expiration after bronchial thermoplasty
Abstract
Background
Bronchial thermoplasty (BT) is a bronchoscopic treatment that can ameliorate the symptoms of severe asthma. However, little is known about the mechanism by which BT improves exertional dyspnea without significantly changing the resting pulmonary function in asthmatics. To understand the mechanism, cardiopulmonary variables were investigated using cardiopulmonary exercise testing (CPET) in a patient with severe asthma before and after BT.
Case presentation
A 57-year-old Japanese man visited our hospital for consultation of the intractable asthma, which we managed with three treatment sessions of BT. Comparison of the findings pre-BT and at 1 year after BT demonstrated that (1) the resting tests for respiration showed no improvement in forced expiratory volume in 1 s, but the forced oscillation technique showed decreases in both inhalation and exhalation respiratory resistance values, and (2) the CPET results showed (i) improvement in exertional dyspnea, exercise endurance, and arterial oxygen saturation at the end of exercise; (ii) that the expiratory tidal volume exceeded the inspiratory tidal volume during exercise, which implied that a sufficient exhalation enabled longer inspiratory time and adequate oxygen absorption; and (iii) that an increase in respiratory frequency could be prevented throughout exercise.
Conclusions
This case report described a novel mechanism of BT in improving exertional dyspnea and exercise duration, which was brought about by ventilatory improvements related to the breathing pattern of inspiration to expiration.
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First reported case in Canada of anaphylaxis to lupine in a child with peanut allergy
Abstract
Background
Lupine is a member of the legume family and is often used in many food products in Europe (e.g. pasta, pizza, sauces, etc.) as a wheat or soy substitute. Lupine cross-reacts with peanut, and cases of allergic reactions to lupine in peanut-allergic patients have been reported in Europe mainly. In contrast, lupine as an ingredient in food products is relatively new to the Canadian market.
Case presentation
We describe a 10-year old boy with diagnosed peanut and tree-nut allergy, who developed anaphylaxis to lupine flour in May 2017. A few minutes after eating a pre-made pancake mix that didn't contain any of his known allergens (peanuts, tree nuts), he developed oral pruritis followed by throat tightness, severe stomach ache, lightheadedness, cough, hoarse throat, nasal congestion, sneezing, and fatigue. He refused epinephrine, but was given cetirizine. The symptoms resolved after 3 h, but he was still unwell the following day. In a conversation between the mother and the allergist, it was determined that lupine was likely the cause of the reaction. To confirm, he was brought into clinic for skin testing to lupine. Results were consistent with lupine allergy (pancake mix: 10 × 7 mm, lupine bean: 12 × 6 mm). The family has since reported this to the Canadian Food Inspection Agency, resulting in a product recall and a consumer advisory bulletin published by Health Canada.
Conclusions
This is the first reported case of allergic reaction to lupine in Canada, and highlights the need for education of Canadian families with peanut allergy as well as allergists, regarding the possibility of cross-reactivity between peanut and lupine and its new presence in the Canadian food supply. In addition, a precautionary label for those with peanut allergy who purchase products containing lupine should be considered. This case illustrates also the need for a clear mechanism for consumers and allergists to report emerging food allergens to regulatory bodies such as Health Canada.
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Improvement of exertional dyspnea and breathing pattern of inspiration to expiration after bronchial thermoplasty
Abstract
Background
Bronchial thermoplasty (BT) is a bronchoscopic treatment that can ameliorate the symptoms of severe asthma. However, little is known about the mechanism by which BT improves exertional dyspnea without significantly changing the resting pulmonary function in asthmatics. To understand the mechanism, cardiopulmonary variables were investigated using cardiopulmonary exercise testing (CPET) in a patient with severe asthma before and after BT.
Case presentation
A 57-year-old Japanese man visited our hospital for consultation of the intractable asthma, which we managed with three treatment sessions of BT. Comparison of the findings pre-BT and at 1 year after BT demonstrated that (1) the resting tests for respiration showed no improvement in forced expiratory volume in 1 s, but the forced oscillation technique showed decreases in both inhalation and exhalation respiratory resistance values, and (2) the CPET results showed (i) improvement in exertional dyspnea, exercise endurance, and arterial oxygen saturation at the end of exercise; (ii) that the expiratory tidal volume exceeded the inspiratory tidal volume during exercise, which implied that a sufficient exhalation enabled longer inspiratory time and adequate oxygen absorption; and (iii) that an increase in respiratory frequency could be prevented throughout exercise.
Conclusions
This case report described a novel mechanism of BT in improving exertional dyspnea and exercise duration, which was brought about by ventilatory improvements related to the breathing pattern of inspiration to expiration.
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First reported case in Canada of anaphylaxis to lupine in a child with peanut allergy
Abstract
Background
Lupine is a member of the legume family and is often used in many food products in Europe (e.g. pasta, pizza, sauces, etc.) as a wheat or soy substitute. Lupine cross-reacts with peanut, and cases of allergic reactions to lupine in peanut-allergic patients have been reported in Europe mainly. In contrast, lupine as an ingredient in food products is relatively new to the Canadian market.
Case presentation
We describe a 10-year old boy with diagnosed peanut and tree-nut allergy, who developed anaphylaxis to lupine flour in May 2017. A few minutes after eating a pre-made pancake mix that didn't contain any of his known allergens (peanuts, tree nuts), he developed oral pruritis followed by throat tightness, severe stomach ache, lightheadedness, cough, hoarse throat, nasal congestion, sneezing, and fatigue. He refused epinephrine, but was given cetirizine. The symptoms resolved after 3 h, but he was still unwell the following day. In a conversation between the mother and the allergist, it was determined that lupine was likely the cause of the reaction. To confirm, he was brought into clinic for skin testing to lupine. Results were consistent with lupine allergy (pancake mix: 10 × 7 mm, lupine bean: 12 × 6 mm). The family has since reported this to the Canadian Food Inspection Agency, resulting in a product recall and a consumer advisory bulletin published by Health Canada.
Conclusions
This is the first reported case of allergic reaction to lupine in Canada, and highlights the need for education of Canadian families with peanut allergy as well as allergists, regarding the possibility of cross-reactivity between peanut and lupine and its new presence in the Canadian food supply. In addition, a precautionary label for those with peanut allergy who purchase products containing lupine should be considered. This case illustrates also the need for a clear mechanism for consumers and allergists to report emerging food allergens to regulatory bodies such as Health Canada.
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IgE-Mediated Food Allergy
Abstract
Food allergies are defined as adverse immune responses to food proteins that result in typical clinical symptoms involving the dermatologic, respiratory, gastrointestinal, cardiovascular, and/or neurologic systems. IgE-mediated food-allergic disease differs from non-IgE-mediated disease because the pathophysiology results from activation of the immune system, causing a T helper 2 response which results in IgE binding to Fcε receptors on effector cells like mast cells and basophils. The activation of these cells causes release of histamine and other preformed mediators, and rapid symptom onset, in contrast with non-IgE-mediated food allergy which is more delayed in onset. The diagnosis of IgE-mediated food allergy requires a history of classic clinical symptoms and evidence of food-specific IgE by either skin-prick or serum-specific IgE testing. Symptoms of IgE-mediated food allergies range from mild to severe. The severity of symptoms is not predicted by the level of specific IgE or skin test wheal size, but the likelihood of symptom onset is directly related. Diagnosis is excluded when a patient can ingest the suspected food without clinical symptoms and may require an in-office oral food challenge if testing for food-specific IgE by serum or skin testing is negative or low. Anaphylaxis is the most severe form of the clinical manifestation of IgE-mediated food allergy, and injectable epinephrine is the first-line treatment. Management of food allergies requires strict avoidance measures, counseling of the family about constant vigilance, and prompt treatment of allergic reactions with emergency medications. Guidelines have changed recently to include early introduction of peanuts at 4–6 months of life. Early introduction is recommended to prevent the development of peanut allergy. Future treatments for IgE-mediated food allergy evaluated in clinical trials include epicutaneous, sublingual, and oral immunotherapy.
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IgE-Mediated Food Allergy
Abstract
Food allergies are defined as adverse immune responses to food proteins that result in typical clinical symptoms involving the dermatologic, respiratory, gastrointestinal, cardiovascular, and/or neurologic systems. IgE-mediated food-allergic disease differs from non-IgE-mediated disease because the pathophysiology results from activation of the immune system, causing a T helper 2 response which results in IgE binding to Fcε receptors on effector cells like mast cells and basophils. The activation of these cells causes release of histamine and other preformed mediators, and rapid symptom onset, in contrast with non-IgE-mediated food allergy which is more delayed in onset. The diagnosis of IgE-mediated food allergy requires a history of classic clinical symptoms and evidence of food-specific IgE by either skin-prick or serum-specific IgE testing. Symptoms of IgE-mediated food allergies range from mild to severe. The severity of symptoms is not predicted by the level of specific IgE or skin test wheal size, but the likelihood of symptom onset is directly related. Diagnosis is excluded when a patient can ingest the suspected food without clinical symptoms and may require an in-office oral food challenge if testing for food-specific IgE by serum or skin testing is negative or low. Anaphylaxis is the most severe form of the clinical manifestation of IgE-mediated food allergy, and injectable epinephrine is the first-line treatment. Management of food allergies requires strict avoidance measures, counseling of the family about constant vigilance, and prompt treatment of allergic reactions with emergency medications. Guidelines have changed recently to include early introduction of peanuts at 4–6 months of life. Early introduction is recommended to prevent the development of peanut allergy. Future treatments for IgE-mediated food allergy evaluated in clinical trials include epicutaneous, sublingual, and oral immunotherapy.
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Why fix it if it ’s not broken! The role of audiologists in families of hearing children born to deaf parents
. (Source: Hearing, Balance and Communication)
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Measurement of pitch perception as a function of cochlear implant electrode and its effect on speech perception with different frequency allocations
. (Source: International Journal of Audiology)
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Why fix it if it ’s not broken! The role of audiologists in families of hearing children born to deaf parents
. (Source: Hearing, Balance and Communication)
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Measurement of pitch perception as a function of cochlear implant electrode and its effect on speech perception with different frequency allocations
. (Source: International Journal of Audiology)
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IgE-Mediated Food Allergy
Abstract
Food allergies are defined as adverse immune responses to food proteins that result in typical clinical symptoms involving the dermatologic, respiratory, gastrointestinal, cardiovascular, and/or neurologic systems. IgE-mediated food-allergic disease differs from non-IgE-mediated disease because the pathophysiology results from activation of the immune system, causing a T helper 2 response which results in IgE binding to Fcε receptors on effector cells like mast cells and basophils. The activation of these cells causes release of histamine and other preformed mediators, and rapid symptom onset, in contrast with non-IgE-mediated food allergy which is more delayed in onset. The diagnosis of IgE-mediated food allergy requires a history of classic clinical symptoms and evidence of food-specific IgE by either skin-prick or serum-specific IgE testing. Symptoms of IgE-mediated food allergies range from mild to severe. The severity of symptoms is not predicted by the level of specific IgE or skin test wheal size, but the likelihood of symptom onset is directly related. Diagnosis is excluded when a patient can ingest the suspected food without clinical symptoms and may require an in-office oral food challenge if testing for food-specific IgE by serum or skin testing is negative or low. Anaphylaxis is the most severe form of the clinical manifestation of IgE-mediated food allergy, and injectable epinephrine is the first-line treatment. Management of food allergies requires strict avoidance measures, counseling of the family about constant vigilance, and prompt treatment of allergic reactions with emergency medications. Guidelines have changed recently to include early introduction of peanuts at 4–6 months of life. Early introduction is recommended to prevent the development of peanut allergy. Future treatments for IgE-mediated food allergy evaluated in clinical trials include epicutaneous, sublingual, and oral immunotherapy.
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IgE-Mediated Food Allergy
Abstract
Food allergies are defined as adverse immune responses to food proteins that result in typical clinical symptoms involving the dermatologic, respiratory, gastrointestinal, cardiovascular, and/or neurologic systems. IgE-mediated food-allergic disease differs from non-IgE-mediated disease because the pathophysiology results from activation of the immune system, causing a T helper 2 response which results in IgE binding to Fcε receptors on effector cells like mast cells and basophils. The activation of these cells causes release of histamine and other preformed mediators, and rapid symptom onset, in contrast with non-IgE-mediated food allergy which is more delayed in onset. The diagnosis of IgE-mediated food allergy requires a history of classic clinical symptoms and evidence of food-specific IgE by either skin-prick or serum-specific IgE testing. Symptoms of IgE-mediated food allergies range from mild to severe. The severity of symptoms is not predicted by the level of specific IgE or skin test wheal size, but the likelihood of symptom onset is directly related. Diagnosis is excluded when a patient can ingest the suspected food without clinical symptoms and may require an in-office oral food challenge if testing for food-specific IgE by serum or skin testing is negative or low. Anaphylaxis is the most severe form of the clinical manifestation of IgE-mediated food allergy, and injectable epinephrine is the first-line treatment. Management of food allergies requires strict avoidance measures, counseling of the family about constant vigilance, and prompt treatment of allergic reactions with emergency medications. Guidelines have changed recently to include early introduction of peanuts at 4–6 months of life. Early introduction is recommended to prevent the development of peanut allergy. Future treatments for IgE-mediated food allergy evaluated in clinical trials include epicutaneous, sublingual, and oral immunotherapy.
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Asthma and other allergic diseases in relation to suicidal behavior among South Korean adolescents
Adolescent asthma can be the cause of social and psychological problems. We investigated the association between asthma with other allergic diseases and suicidal risk behavior among South Korean adolescents using nationally representative data. (Source: Journal of Psychosomatic Research)
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Local Anesthetics (LAs) and Cancer Cell Progression: Is There an Oncologic Protective Role for LAs in Clinical Practice?
Abstract
Purpose of Review
The purpose of this article is to provide a brief review of current literature examining the potential oncologic protective role local anesthetics may provide in the perioperative setting during cancer surgery.
Recent Findings
Paradoxically, curative surgery for cancer appears to favor the development of recurrences and distant metastasis. The accumulated knowledge about cancer biology and our understanding of the pathophysiological events occurring during the perioperative period have opened several theories on potential mechanisms for this century old observation. In such, cell-mediated immune response, the first line attack against cancer is suppressed during the perioperative period possibly providing circulating tumor cells with a fruitful environment allowing them to escape the immune system to form local recurrence and metastasis. In parallel, surgical stress, acute pain, and inflammatory cytokines released during surgery all directly or indirectly contribute to the immunosuppression state. Current data indicates that surgery itself cannot be regarded as the sole culprit for this paradox, and other factors during the perioperative period such as anesthetic drugs or anesthesia techniques are conceivably involved as well. As an example, volatile anesthetic seem to have negative effects while propofol appears to have protective effects. Opioids were also found to be immunosuppressive and therefore may not represent an ideal choice. Of the drugs used in anesthesia, local anesthetics seem to be the most attractive with regard to cancer surgery.
Summary
Depending on their mode of administration, local anesthetics have been found in several reports to directly or indirectly blunt the systemic response to surgery, preserve immune function, alter cytokine release, and interfere with cancer cell signaling pathways. They are also analgesic and have anti-inflammatory properties. The former and the latter are sought effects in the perioperative period. However, their impact on recurrence, overall survival and metastasis remains controversial.
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Asthma and other allergic diseases in relation to suicidal behavior among South Korean adolescents
Adolescent asthma can be the cause of social and psychological problems. We investigated the association between asthma with other allergic diseases and suicidal risk behavior among South Korean adolescents using nationally representative data. (Source: Journal of Psychosomatic Research)
MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
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Local Anesthetics (LAs) and Cancer Cell Progression: Is There an Oncologic Protective Role for LAs in Clinical Practice?
Abstract
Purpose of Review
The purpose of this article is to provide a brief review of current literature examining the potential oncologic protective role local anesthetics may provide in the perioperative setting during cancer surgery.
Recent Findings
Paradoxically, curative surgery for cancer appears to favor the development of recurrences and distant metastasis. The accumulated knowledge about cancer biology and our understanding of the pathophysiological events occurring during the perioperative period have opened several theories on potential mechanisms for this century old observation. In such, cell-mediated immune response, the first line attack against cancer is suppressed during the perioperative period possibly providing circulating tumor cells with a fruitful environment allowing them to escape the immune system to form local recurrence and metastasis. In parallel, surgical stress, acute pain, and inflammatory cytokines released during surgery all directly or indirectly contribute to the immunosuppression state. Current data indicates that surgery itself cannot be regarded as the sole culprit for this paradox, and other factors during the perioperative period such as anesthetic drugs or anesthesia techniques are conceivably involved as well. As an example, volatile anesthetic seem to have negative effects while propofol appears to have protective effects. Opioids were also found to be immunosuppressive and therefore may not represent an ideal choice. Of the drugs used in anesthesia, local anesthetics seem to be the most attractive with regard to cancer surgery.
Summary
Depending on their mode of administration, local anesthetics have been found in several reports to directly or indirectly blunt the systemic response to surgery, preserve immune function, alter cytokine release, and interfere with cancer cell signaling pathways. They are also analgesic and have anti-inflammatory properties. The former and the latter are sought effects in the perioperative period. However, their impact on recurrence, overall survival and metastasis remains controversial.
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Orthognathic surgery induces genome ‐wide changes longitudinally in DNA methylation in saliva
Oral Diseases,Volume 0, Issue ja, -Not available-. (Source: Oral Diseases)
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Barrier use during oro ‐genital sex and oral HPV prevalence: analysis of NHANES 2009‐2014
Oral Diseases,Volume 0, Issue ja, -Not available-. (Source: Oral Diseases)
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Barrier use during oro ‐genital sex and oral HPV prevalence: analysis of NHANES 2009‐2014
Oral Diseases,Volume 0, Issue ja, -Not available-. (Source: Oral Diseases)
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Orthognathic surgery induces genome ‐wide changes longitudinally in DNA methylation in saliva
Oral Diseases,Volume 0, Issue ja, -Not available-. (Source: Oral Diseases)
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Suppressive oligodeoxynucleotide-induced dendritic cells rein the aggravation of osteoarthritis in mice.
CONCLUSION: Transfer of suppressive oligodeoxynucleotides-induced autologous DCs may represent a potential agent to control the aggravation of OA in patients. PMID: 30366509 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
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Suppressive oligodeoxynucleotide-induced dendritic cells rein the aggravation of osteoarthritis in mice.
CONCLUSION: Transfer of suppressive oligodeoxynucleotides-induced autologous DCs may represent a potential agent to control the aggravation of OA in patients. PMID: 30366509 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)
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EASI p ‐EASI: predicting disease severity in atopic dermatitis patients treated with Cyclosporin A
Allergy,Volume 0, Issue ja, -Not available-. (Source: Allergy)
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The protective effect of cheese consumption at 18 months on allergic diseases in the first 6 years
Allergy,Volume 0, Issue ja, -Not available-. (Source: Allergy)
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The protective effect of cheese consumption at 18 months on allergic diseases in the first 6 years
Allergy,Volume 0, Issue ja, -Not available-. (Source: Allergy)
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Anti ‐β2‐glycoprotein I antibody with DNA binding activity enters living monocytes via cell surface DNA & induces tissue factor expression
Clinical&Experimental Immunology,Volume 0, Issue ja, -Not available-. (Source: Clinical and Experimental Immunology)
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Anti ‐β2‐glycoprotein I antibody with DNA binding activity enters living monocytes via cell surface DNA & induces tissue factor expression
Clinical&Experimental Immunology,Volume 0, Issue ja, -Not available-. (Source: Clinical and Experimental Immunology)
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EASI p ‐EASI: predicting disease severity in atopic dermatitis patients treated with Cyclosporin A
Allergy,Volume 0, Issue ja, -Not available-. (Source: Allergy)
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A predominant Th1 polarization is present in synovial fluid of end ‐stage osteoarthritic knee joints – analysis of peripheral blood, synovial fluid & synovial membrane
Clinical&Experimental Immunology,Volume 0, Issue ja, -Not available-. (Source: Clinical and Experimental Immunology)
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A predominant Th1 polarization is present in synovial fluid of end ‐stage osteoarthritic knee joints – analysis of peripheral blood, synovial fluid & synovial membrane
Clinical&Experimental Immunology,Volume 0, Issue ja, -Not available-. (Source: Clinical and Experimental Immunology)
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Swept-Source Optical Coherence Tomography Analysis in Asthmatic Children Under Inhaled Corticosteroid Therapy.
CONCLUSIONS: The SS-OCT revealed that asthmatic children under inhaled corticosteroid treatment have lower RNFLT than healthy subjects. PMID: 30360658 [PubMed - as supplied by publisher] (Source: Cutaneous and Ocular Toxicology)
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Swept-Source Optical Coherence Tomography Analysis in Asthmatic Children Under Inhaled Corticosteroid Therapy.
CONCLUSIONS: The SS-OCT revealed that asthmatic children under inhaled corticosteroid treatment have lower RNFLT than healthy subjects. PMID: 30360658 [PubMed - as supplied by publisher] (Source: Cutaneous and Ocular Toxicology)
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Regional excitation-inhibition balance predicts default-mode network deactivation via functional connectivity
Publication date: 15 January 2019
Source: NeuroImage, Volume 185
Author(s): Hong Gu, Yuzheng Hu, Xi Chen, Yong He, Yihong Yang
Abstract
Deactivation of the default mode network (DMN) is one of the most reliable observations from neuroimaging and has significant implications in development, aging, and various neuropsychiatric disorders. However, the neural mechanism underlying DMN deactivation remains elusive. As the coordination of regional neurochemical substrates and interregional neural interactions are both essential in support of brain functions, a quantitative description of how they impact DMN deactivation may provide new insights into the mechanism. Using an n-back working memory task fMRI and magnetic resonance spectroscopy, we probed the pairwise relationship between task-induced deactivation, interregional functional connectivity and regional excitation-inhibition balance (evaluated by glutamate/GABA ratio) in the posterior cingulate cortex/precuneus (PCC/PCu). Task-induced PCC/PCu deactivation correlated with its excitation-inhibition balance and interregional functional connectivity, where participants with lower glutamate/GABA ratio, stronger intra-DMN connections and stronger antagonistic DMN-SN (salience network)/ECN (executive control network) inter-network connections had greater PCC/PCu deactivation. Mediation analyses revealed that the DMN-SN functional interactions partially mediated the relationship between task-induced deactivation and the excitation-inhibition balance at the PCC/PCu. The triple-relationship discovered in the present study has the potential to bridge DMN-deactivation related findings from various neuroimaging modalities and may provide new insights into the neural mechanism of DMN deactivation. Moreover, this finding may have significant implications for neuropsychiatric disorders related to the DMN dysfunction and suggests an integrated application of pharmacological and neuromodulation-based strategies for rescuing DMN deactivation deficits.
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Regional excitation-inhibition balance predicts default-mode network deactivation via functional connectivity
Publication date: 15 January 2019
Source: NeuroImage, Volume 185
Author(s): Hong Gu, Yuzheng Hu, Xi Chen, Yong He, Yihong Yang
Abstract
Deactivation of the default mode network (DMN) is one of the most reliable observations from neuroimaging and has significant implications in development, aging, and various neuropsychiatric disorders. However, the neural mechanism underlying DMN deactivation remains elusive. As the coordination of regional neurochemical substrates and interregional neural interactions are both essential in support of brain functions, a quantitative description of how they impact DMN deactivation may provide new insights into the mechanism. Using an n-back working memory task fMRI and magnetic resonance spectroscopy, we probed the pairwise relationship between task-induced deactivation, interregional functional connectivity and regional excitation-inhibition balance (evaluated by glutamate/GABA ratio) in the posterior cingulate cortex/precuneus (PCC/PCu). Task-induced PCC/PCu deactivation correlated with its excitation-inhibition balance and interregional functional connectivity, where participants with lower glutamate/GABA ratio, stronger intra-DMN connections and stronger antagonistic DMN-SN (salience network)/ECN (executive control network) inter-network connections had greater PCC/PCu deactivation. Mediation analyses revealed that the DMN-SN functional interactions partially mediated the relationship between task-induced deactivation and the excitation-inhibition balance at the PCC/PCu. The triple-relationship discovered in the present study has the potential to bridge DMN-deactivation related findings from various neuroimaging modalities and may provide new insights into the neural mechanism of DMN deactivation. Moreover, this finding may have significant implications for neuropsychiatric disorders related to the DMN dysfunction and suggests an integrated application of pharmacological and neuromodulation-based strategies for rescuing DMN deactivation deficits.
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No De-escalation of Therapy for HPV+ Throat Cancer
Source: www.medscape.com Author: Alexander M. Castellino, PhD Another trial has shown that de-escalating therapy does not work in patients with good […]
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No De-escalation of Therapy for HPV+ Throat Cancer
Source: www.medscape.com Author: Alexander M. Castellino, PhD Another trial has shown that de-escalating therapy does not work in patients with good […]
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Vocal fold paresis as a surgical complication: our 10‐year experience with 162 incidents
Clinical Otolaryngology, Volume 0, Issue ja, -Not available-.
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Vocal fold paresis as a surgical complication: our 10‐year experience with 162 incidents
Clinical Otolaryngology, Volume 0, Issue ja, -Not available-.
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EASI p‐EASI: predicting disease severity in atopic dermatitis patients treated with Cyclosporin A
Allergy, Volume 0, Issue ja, -Not available-.
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EASI p‐EASI: predicting disease severity in atopic dermatitis patients treated with Cyclosporin A
Allergy, Volume 0, Issue ja, -Not available-.
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No De-escalation of Therapy for HPV+ Throat Cancer
Source: www.medscape.com Author: Alexander M. Castellino, PhD Another trial has shown that de-escalating therapy does not work in patients with good […]
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2yBESrR
No De-escalation of Therapy for HPV+ Throat Cancer
Source: www.medscape.com Author: Alexander M. Castellino, PhD Another trial has shown that de-escalating therapy does not work in patients with good […]
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2yBESrR
Indications of Transnasal Humidified Rapid‐Insufflation Ventilatory Exchange (THRIVE) in laryngoscopy, a prospective study of 19 cases
Clinical Otolaryngology, Volume 0, Issue ja, -Not available-.
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Indications of Transnasal Humidified Rapid‐Insufflation Ventilatory Exchange (THRIVE) in laryngoscopy, a prospective study of 19 cases
Clinical Otolaryngology, Volume 0, Issue ja, -Not available-.
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Table of contents
The Laryngoscope, Volume 128, Issue S3, Page iii-iv, October 2018.
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Masthead
The Laryngoscope, Volume 128, Issue S3, Page i-ii, October 2018.
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Table of contents
The Laryngoscope, Volume 128, Issue 10, Page iii-vi, October 2018.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PvltTa
Masthead
The Laryngoscope, Volume 128, Issue 10, Page i-ii, October 2018.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2RhIK8o
Table of contents
The Laryngoscope, Volume 128, Issue S3, Page iii-iv, October 2018.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Pqfb7j
Masthead
The Laryngoscope, Volume 128, Issue S3, Page i-ii, October 2018.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2RhIPcc
Table of contents
The Laryngoscope, Volume 128, Issue 10, Page iii-vi, October 2018.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PvltTa
Masthead
The Laryngoscope, Volume 128, Issue 10, Page i-ii, October 2018.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2RhIK8o
The protective effect of cheese consumption at 18 months on allergic diseases in the first 6 years
Allergy, Volume 0, Issue ja, -Not available-.
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The protective effect of cheese consumption at 18 months on allergic diseases in the first 6 years
Allergy, Volume 0, Issue ja, -Not available-.
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How do I keep my kids out of the ER this Halloween?
I have worked most of the last 20 Halloweens in the pediatric emergency department (ED), so I've seen how a split second can ruin your child's holiday. Here are some things you can do to plan ahead and avoid the ED. 1. Avoid trip hazards It's a recipe for mishap. Your child is in a costume that may have long hems or unusual shoes or a mask limiting their normal vision. A crack in the sidewalk and a running child usually results in a face plant on the concrete, a split lip, bleeding all over the costume and a rushed trip to the ED. Carry a flashlight and illuminate where you're walking. The Boston area sidewalks aren't necessarily known for being in great condition. Make sure the hem of your child's costume is clear of their feet. If your child's costume includes a mask, ma...
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Live the Wheat Belly lifestyle, get off prescription medications
Take a look at the list of medications people have been able to stop by following the Wheat Belly lifestyle. These represent medications prescribed by doctors to, in effect, "treat" the consequences of consuming wheat and grains. They prescribe drugs to treat inflammation, swelling, skin rashes, gastrointestinal irritation, high blood sugars, airway allergy, joint pain, high blood pressure, leg edema and other abnormal effects caused by wheat and grains. The list includes anti-inflammatory and pain medication, acid reflux drugs, injectable and oral drugs for diabetes, numerous anti-hypertensive agents, asthma inhalers and allergy drugs, drugs for migraine headaches, and others. It is truly an astounding list that represents drugs that were unnecessary, costly, and filled with s...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2ENExrD
How do I keep my kids out of the ER this Halloween?
I have worked most of the last 20 Halloweens in the pediatric emergency department (ED), so I've seen how a split second can ruin your child's holiday. Here are some things you can do to plan ahead and avoid the ED. 1. Avoid trip hazards It's a recipe for mishap. Your child is in a costume that may have long hems or unusual shoes or a mask limiting their normal vision. A crack in the sidewalk and a running child usually results in a face plant on the concrete, a split lip, bleeding all over the costume and a rushed trip to the ED. Carry a flashlight and illuminate where you're walking. The Boston area sidewalks aren't necessarily known for being in great condition. Make sure the hem of your child's costume is clear of their feet. If your child's costume includes a mask, ma...
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2AwFeSj
Live the Wheat Belly lifestyle, get off prescription medications
Take a look at the list of medications people have been able to stop by following the Wheat Belly lifestyle. These represent medications prescribed by doctors to, in effect, "treat" the consequences of consuming wheat and grains. They prescribe drugs to treat inflammation, swelling, skin rashes, gastrointestinal irritation, high blood sugars, airway allergy, joint pain, high blood pressure, leg edema and other abnormal effects caused by wheat and grains. The list includes anti-inflammatory and pain medication, acid reflux drugs, injectable and oral drugs for diabetes, numerous anti-hypertensive agents, asthma inhalers and allergy drugs, drugs for migraine headaches, and others. It is truly an astounding list that represents drugs that were unnecessary, costly, and filled with s...
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Direct oral anticoagulant agents: are they so safe?
Oral Diseases, Volume 0, Issue ja, -Not available-.
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Direct oral anticoagulant agents: are they so safe?
Oral Diseases, Volume 0, Issue ja, -Not available-.
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Immunological and Clinical Characteristics of Systemic Lupus Erythematosus: A Series from Morocco.
Authors: Zian Z, Maamar M, Aouni ME, Barakat A, Naima Ghailani Nourouti, El Aouad R, Arji N, Bennani Mechita M Abstract Systemic Lupus Erythematosus (SLE) is a complex autoimmune disease with a high female predominance. To date, studies about SLE in Morocco are few. This retrospective study describes the clinical and immunological features in a series of 50 SLE Moroccan patients in University Hospital Center of Rabat, Morocco, between December 2011 and December 2013. All patients were screened for antinuclear antibodies (ANA) and anti-DNA antibodies by indirect immunofluorescence, followed by identification of anti-extractable nuclear antigen antibodies by ELISA. The female to male ratio was 6.1:1. Mean age was 31.72 years. The main clinical manifestations were arthritis (82%), muc...
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Hydrogen Sulfide Protects against Chemical Hypoxia-Induced Injury via Attenuation of ROS-Mediated Ca2+ Overload and Mitochondrial Dysfunction in Human Bronchial Epithelial Cells.
Authors: Liu CX, Tan YR, Xiang Y, Liu C, Liu XA, Qin XQ Abstract Oxidative stress induced by hypoxia/ischemia resulted in the excessive reactive oxygen species (ROS) and the relative inadequate antioxidants. As the initial barrier to environmental pollutants and allergic stimuli, airway epithelial cell is vulnerable to oxidative stress. In recent years, the antioxidant effect of hydrogen sulfide (H2S) has attracted much attention. Therefore, in this study, we explored the impact of H2S on CoCl2-induced cell injury in 16HBE14o- cells. The effect of CoCl2 on the cell viability was detected by Cell Counting Kit (CCK-8) and the level of ROS in 16HBE14o- cells in response to varying doses (100-1000 μmol/L) of CoCl2 (a common chemical mimic of hypoxia) was measured by using fluorescent ...
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Hydrogen Sulfide Protects against Chemical Hypoxia-Induced Injury via Attenuation of ROS-Mediated Ca2+ Overload and Mitochondrial Dysfunction in Human Bronchial Epithelial Cells.
Authors: Liu CX, Tan YR, Xiang Y, Liu C, Liu XA, Qin XQ Abstract Oxidative stress induced by hypoxia/ischemia resulted in the excessive reactive oxygen species (ROS) and the relative inadequate antioxidants. As the initial barrier to environmental pollutants and allergic stimuli, airway epithelial cell is vulnerable to oxidative stress. In recent years, the antioxidant effect of hydrogen sulfide (H2S) has attracted much attention. Therefore, in this study, we explored the impact of H2S on CoCl2-induced cell injury in 16HBE14o- cells. The effect of CoCl2 on the cell viability was detected by Cell Counting Kit (CCK-8) and the level of ROS in 16HBE14o- cells in response to varying doses (100-1000 μmol/L) of CoCl2 (a common chemical mimic of hypoxia) was measured by using fluorescent ...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2D8fzBL
The Plant Proteinase Inhibitor CrataBL Plays a Role in Controlling Asthma Response in Mice.
Conclusion. CrataBL contributes to the control of hyperresponsiveness, pulmonary inflammation, extracellular matrix remodeling, and oxidative stress responses in an animal model of chronic allergic pulmonary inflammation. PMID: 30364003 [PubMed - in process] (Source: Biomed Res)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2D8fvC1
Immunological and Clinical Characteristics of Systemic Lupus Erythematosus: A Series from Morocco.
Authors: Zian Z, Maamar M, Aouni ME, Barakat A, Naima Ghailani Nourouti, El Aouad R, Arji N, Bennani Mechita M Abstract Systemic Lupus Erythematosus (SLE) is a complex autoimmune disease with a high female predominance. To date, studies about SLE in Morocco are few. This retrospective study describes the clinical and immunological features in a series of 50 SLE Moroccan patients in University Hospital Center of Rabat, Morocco, between December 2011 and December 2013. All patients were screened for antinuclear antibodies (ANA) and anti-DNA antibodies by indirect immunofluorescence, followed by identification of anti-extractable nuclear antigen antibodies by ELISA. The female to male ratio was 6.1:1. Mean age was 31.72 years. The main clinical manifestations were arthritis (82%), muc...
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2JjHL4L
Immune components of early breastmilk: association with maternal factors and with reported food allergy in childhood
Pediatric Allergy and Immunology,Volume 0, Issue ja, -Not available-. (Source: Pediatric Allergy and Immunology)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2JknyvO
The Plant Proteinase Inhibitor CrataBL Plays a Role in Controlling Asthma Response in Mice.
Conclusion. CrataBL contributes to the control of hyperresponsiveness, pulmonary inflammation, extracellular matrix remodeling, and oxidative stress responses in an animal model of chronic allergic pulmonary inflammation. PMID: 30364003 [PubMed - in process] (Source: Biomed Res)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2D8fvC1
Immune components of early breastmilk: association with maternal factors and with reported food allergy in childhood
Pediatric Allergy and Immunology,Volume 0, Issue ja, -Not available-. (Source: Pediatric Allergy and Immunology)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2JknyvO
Relationships among Antibodies against Extractable Nuclear Antigens, Antinuclear Antibodies, and Autoimmune Diseases in a Brazilian Public Hospital.
Authors: Banhuk FW, Pahim BC, Jorge AS, Menolli RA Abstract One characteristic of autoimmune diseases (ADs) is the production of autoantibodies for extractable nuclear autoantigens, which may aid in the discrimination of the different types of autoimmune diseases and is related to different antinuclear antibody (ANA) patterns. The present study verified the profile of patient samples tested for extractable nuclear antigens (ENA) antibodies in a public hospital and correlated the ENA results with ANA patterns and patient diagnoses. The study reviewed data in the medical records of patients who underwent anti-ENA tests at a public hospital in the West of the State of Paraná from February 2011 to January 2017. Patients were classified according to age, ethnicity, gender, anti-ENA tes...
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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2JjUMva
Relationships among Antibodies against Extractable Nuclear Antigens, Antinuclear Antibodies, and Autoimmune Diseases in a Brazilian Public Hospital.
Authors: Banhuk FW, Pahim BC, Jorge AS, Menolli RA Abstract One characteristic of autoimmune diseases (ADs) is the production of autoantibodies for extractable nuclear autoantigens, which may aid in the discrimination of the different types of autoimmune diseases and is related to different antinuclear antibody (ANA) patterns. The present study verified the profile of patient samples tested for extractable nuclear antigens (ENA) antibodies in a public hospital and correlated the ENA results with ANA patterns and patient diagnoses. The study reviewed data in the medical records of patients who underwent anti-ENA tests at a public hospital in the West of the State of Paraná from February 2011 to January 2017. Patients were classified according to age, ethnicity, gender, anti-ENA tes...
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