Allergic rhinitis affects around one quarter of the Western European population. Prophylactic allergen immunotherapy may be useful to reduce the risk of acute symptomatic attacks (hayfever). A five-grass polle...
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Κυριακή 23 Σεπτεμβρίου 2018
An observational cohort study of the use of five-grass-pollen extract sublingual immunotherapy during the 2015 pollen season in France
An observational cohort study of the use of five-grass-pollen extract sublingual immunotherapy during the 2015 pollen season in France
Allergic rhinitis affects around one quarter of the Western European population. Prophylactic allergen immunotherapy may be useful to reduce the risk of acute symptomatic attacks (hayfever). A five-grass polle...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2O0B6S3
Primary Cutaneous Non‐Pigmented Mycotic Cyst Contained in an Epidermal Inclusion Cyst: Case Report and Review of the Literature
Journal of Cutaneous Pathology, Volume 0, Issue ja, -Not available-.
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Primary Cutaneous Non‐Pigmented Mycotic Cyst Contained in an Epidermal Inclusion Cyst: Case Report and Review of the Literature
Journal of Cutaneous Pathology, Volume 0, Issue ja, -Not available-.
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A novel methodological approach using superimposed Micro‐CT and STL images to analyze hard and soft tissue volume in immediate and delayed implants with different cervical designs
Clinical Oral Implants Research, EarlyView.
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Histological and micro‐CT analysis of peri‐implant soft and hard tissue healing on implants with different healing abutments configurations
Clinical Oral Implants Research, EarlyView.
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A novel methodological approach using superimposed Micro‐CT and STL images to analyze hard and soft tissue volume in immediate and delayed implants with different cervical designs
Clinical Oral Implants Research, EarlyView.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2NZEooD
Histological and micro‐CT analysis of peri‐implant soft and hard tissue healing on implants with different healing abutments configurations
Clinical Oral Implants Research, EarlyView.
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An observational cohort study of the use of five-grass-pollen extract sublingual immunotherapy during the 2015 pollen season in France
Abstract
Background
Allergic rhinitis affects around one quarter of the Western European population. Prophylactic allergen immunotherapy may be useful to reduce the risk of acute symptomatic attacks (hayfever). A five-grass pollen extract sublingual immunotherapy (5GPE-SLIT) has been developed for the treatment of allergic rhinitis to grass pollen. The objective of this study was to describe real-world treatment patterns with 5GPE-SLIT in France with respect to the prescribing information.
Methods
This prospective cohort study was conducted by 90 community and hospital allergists. Adults and children (> 5 years old) starting a first treatment with 5GPE-SLIT prior to the 2015 pollen season were eligible. Data was collected at the inclusion visit and at the end of the pollen season. The primary outcome variable was compatibility of 5GPE-SLIT prescription with the prescribing information. This was determined with respect to four variables: (1) interval between 5GPE-SLIT initiation and onset of the pollen season ≥ 3 months, (2) age of patient ≥ 5 years, (3) intermittent symptoms or mild symptom severity (4) confirmatory diagnostic test. At study end, symptoms reported during the pollen season and any modifications to treatment or adverse events were documented.
Results
280 adults and 203 children were enrolled. The prescribing information was respected for 82.5% of adults and 86.7% of children. A skin test was performed for all patients. 5GPE-SLIT was started 3–5 months before the pollen season for 85.3%. Treatment was discontinued before the start of the pollen season in 11.0% of patients overall, generally because of an adverse event (78.8% of discontinuations). The mean duration of treatment was 5.2 months in adults and 5.6 months in children. At the end of follow-up, symptoms during the pollen season were intermittent for 75.0% of adults and 85.7% of children, and severity was mild for 61.8 and 66.0% respectively. During 5GPE-SLIT, the following symptoms reported during the previous year were not reported again in > 50% of patients: nasal congestion, rhinorrhoea, repeated sneezing, conjunctivitis and nasal pruritus.
Conclusions
5GPE-SLIT use was generally consistent with prescribing recommendations and was associated with an improvement of AR severity, with resolution of the principal AR symptoms in around half the patients treated.
Trial registration EUPAS9358. Registered 13 May 2015. Not prospectively registered. http://www.encepp.eu/encepp/viewResource.htm?id=16229
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An observational cohort study of the use of five-grass-pollen extract sublingual immunotherapy during the 2015 pollen season in France
Abstract
Background
Allergic rhinitis affects around one quarter of the Western European population. Prophylactic allergen immunotherapy may be useful to reduce the risk of acute symptomatic attacks (hayfever). A five-grass pollen extract sublingual immunotherapy (5GPE-SLIT) has been developed for the treatment of allergic rhinitis to grass pollen. The objective of this study was to describe real-world treatment patterns with 5GPE-SLIT in France with respect to the prescribing information.
Methods
This prospective cohort study was conducted by 90 community and hospital allergists. Adults and children (> 5 years old) starting a first treatment with 5GPE-SLIT prior to the 2015 pollen season were eligible. Data was collected at the inclusion visit and at the end of the pollen season. The primary outcome variable was compatibility of 5GPE-SLIT prescription with the prescribing information. This was determined with respect to four variables: (1) interval between 5GPE-SLIT initiation and onset of the pollen season ≥ 3 months, (2) age of patient ≥ 5 years, (3) intermittent symptoms or mild symptom severity (4) confirmatory diagnostic test. At study end, symptoms reported during the pollen season and any modifications to treatment or adverse events were documented.
Results
280 adults and 203 children were enrolled. The prescribing information was respected for 82.5% of adults and 86.7% of children. A skin test was performed for all patients. 5GPE-SLIT was started 3–5 months before the pollen season for 85.3%. Treatment was discontinued before the start of the pollen season in 11.0% of patients overall, generally because of an adverse event (78.8% of discontinuations). The mean duration of treatment was 5.2 months in adults and 5.6 months in children. At the end of follow-up, symptoms during the pollen season were intermittent for 75.0% of adults and 85.7% of children, and severity was mild for 61.8 and 66.0% respectively. During 5GPE-SLIT, the following symptoms reported during the previous year were not reported again in > 50% of patients: nasal congestion, rhinorrhoea, repeated sneezing, conjunctivitis and nasal pruritus.
Conclusions
5GPE-SLIT use was generally consistent with prescribing recommendations and was associated with an improvement of AR severity, with resolution of the principal AR symptoms in around half the patients treated.
Trial registration EUPAS9358. Registered 13 May 2015. Not prospectively registered. http://www.encepp.eu/encepp/viewResource.htm?id=16229
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The meshed biological matrix in immediate, definitive breast reconstruction
The aim of this study is to verify the advantages of using a meshed biological matrix (U.I.B.M.-Italian Patent N° 283625) compared to the intact one. A prospective double blind randomized clinical trial with 46 cases of immediate breast reconstruction was performed. The utilization of a meshed biological matrix results in less drainage, reduced need for drains after a few days and a very small percentage rate of seromas and complications, if compared with the utilization of an intact biological matrix.
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An Alternative Approach to the Intraoperative Indocyanine Green Angiography (ICGA) in reconstructive surgery
Indocyanine Green (ICG) is a nontoxic, near- infrared fluorescent dye that has been used for imaging since the 1950s to evaluate liver perfusion and in cardiology.1 It has more recently gained traction in other key areas of reconstructive surgery such as sentinel node biopsy in breast and melanoma skin cancers, lymphangiography in the surgical management of lymphedema and in assessing flap viability in free tissue transfers.1,2
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The meshed biological matrix in immediate, definitive breast reconstruction
The aim of this study is to verify the advantages of using a meshed biological matrix (U.I.B.M.-Italian Patent N° 283625) compared to the intact one. A prospective double blind randomized clinical trial with 46 cases of immediate breast reconstruction was performed. The utilization of a meshed biological matrix results in less drainage, reduced need for drains after a few days and a very small percentage rate of seromas and complications, if compared with the utilization of an intact biological matrix.
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An Alternative Approach to the Intraoperative Indocyanine Green Angiography (ICGA) in reconstructive surgery
Indocyanine Green (ICG) is a nontoxic, near- infrared fluorescent dye that has been used for imaging since the 1950s to evaluate liver perfusion and in cardiology.1 It has more recently gained traction in other key areas of reconstructive surgery such as sentinel node biopsy in breast and melanoma skin cancers, lymphangiography in the surgical management of lymphedema and in assessing flap viability in free tissue transfers.1,2
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The tyrosine kinase inhibitor dasatinib reduces the growth of intracellular Mycobacterium tuberculosis despite impairing T-cell function.
This article is protected by copyright. All rights reserved. PMID: 30242834 [PubMed - as supplied by publisher] (Source: European Journal of Immunology)
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Metformin inhibits IgE- and aryl hydrocarbon receptor-mediated mast cell activation in vitro and in vivo.
This article is protected by copyright. All rights reserved. PMID: 30242842 [PubMed - as supplied by publisher] (Source: European Journal of Immunology)
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The tyrosine kinase inhibitor dasatinib reduces the growth of intracellular Mycobacterium tuberculosis despite impairing T-cell function.
This article is protected by copyright. All rights reserved. PMID: 30242834 [PubMed - as supplied by publisher] (Source: European Journal of Immunology)
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Metformin inhibits IgE- and aryl hydrocarbon receptor-mediated mast cell activation in vitro and in vivo.
This article is protected by copyright. All rights reserved. PMID: 30242842 [PubMed - as supplied by publisher] (Source: European Journal of Immunology)
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Prediction of non-muscle-invasive bladder cancer recurrence by measurement of checkpoint HLAG's receptor ILT2 on peripheral CD8+ T cells.
Conclusions: We demonstrated a strong association between the proportion of circulating CD8+ILT2+ T cells and NMIBC risk of recurrence. Gain in prediction was substantial. If externally validated, such immunological marker could be integrated to predict NMIBC recurrence. PMID: 30237859 [PubMed] (Source: Oncotarget)
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Prediction of non-muscle-invasive bladder cancer recurrence by measurement of checkpoint HLAG's receptor ILT2 on peripheral CD8+ T cells.
Conclusions: We demonstrated a strong association between the proportion of circulating CD8+ILT2+ T cells and NMIBC risk of recurrence. Gain in prediction was substantial. If externally validated, such immunological marker could be integrated to predict NMIBC recurrence. PMID: 30237859 [PubMed] (Source: Oncotarget)
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Proximity Ligation Assay (PLA).
Authors: Alam MS Abstract Proximity ligation assay (PLA), also referred to as Duolink® PLA technology, permits detection of protein-protein interactions in situ (at distances <40 nm) at endogenous protein levels. It exploits specific antibodies identifying (either directly or indirectly) the two proteins of interest and utilizes specific DNA primers covalently linked to the antibodies. A hybridization step followed by a PCR amplification with fluorescent probes permit visualization of spots of proximity by fluorescence microscopy. Since the development of PLA in 2002, it has been increasingly used to detect the interaction between two proteins with high sensitivity and specificity. It is a simple and sensitive technique to study protein-protein interaction in cells. © 2018 by...
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Opportunities for Lipid-Based Probes in the Field of Immunology.
Authors: Koenders STA, Gagestein B, van der Stelt M Abstract Lipids perform a wide range of functions inside the cell, ranging from structural building block of membranes and energy storage to cell signaling. The mode of action of many signaling lipids has remained elusive due to their low abundance, high lipophilicity, and inherent instability. Various chemical biology approaches, such as photoaffinity or activity-based protein profiling methods, have been employed to shed light on the biological role of lipids and the lipid-protein interaction profile. In this review, we will summarize the recent developments in the field of chemical probes to study lipid biology, especially in immunology, and indicate potential avenues for future research. PMID: 30242513 [PubMed - as supplie...
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Extracellular Vesicles in Fungi: Composition and Functions.
Authors: de Toledo Martins S, Szwarc P, Goldenberg S, Alves LR Abstract The comprehension of fungal biology is important for several reasons. Besides being used in biotechnological processes and in the food industry, fungi are also important animal and vegetal pathogens. Fungal diseases in humans have a great importance worldwide, and understanding fungal biology is crucial for treatment and prevention of these diseases, especially because of emerging antifungal resistance that poses great epidemiological risks. Communication through extracellular vesicles is a ubiquitous mechanism of molecule transfer between cells and is used to transport proteins, nucleic acids, lipids, and other biologically active molecules. Several pathogens can produce and transfer extracellular vesicles, an...
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Small-Molecule Inhibitors of PARPs: From Tools for Investigating ADP-Ribosylation to Therapeutics.
Authors: Kirby IT, Cohen MS Abstract Over the last 60 years, poly-ADP-ribose polymerases (PARPs, 17 family members in humans) have emerged as important regulators of physiology and disease. Small-molecule inhibitors have been essential tools for unraveling PARP function, and recently the first PARP inhibitors have been approved for the treatment of various human cancers. However, inhibitors have only been developed for a few PARPs and in vitro profiling has revealed that many of these exhibit polypharmacology across the PARP family. In this review, we discuss the history, development, and current state of the field, highlighting the limitations and opportunities for PARP inhibitor development. PMID: 30242511 [PubMed - as supplied by publisher] (Source: Current Topics in Microb...
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Can obstructive intralymphatic granulomas be the cause of cheilitis granulomatosa?
We report 6 patients with ChG who clinically presented localized edema of the lips. Lip biopsy with pathomorphological and immunohistochemical examination was performed in all cases. We found discrete, non-necrotizing granulomas which were adjacent to numerous blood and lymphatic vessels. The lumen of lymphatic channels was dilated and was either empty or contained lymph and few macrophages or was completely occluded by nearby granulomas. All patients demonstrated a characteristic pattern of lymphangiectasia and perivascular lymphatic aggregates with evidence of non-necrotizing granulomas. None manifested intralymphatic granulomas. These results do not support the view that lymphatic vessel obstruction is caused by intravascular histiocytic granulomas described as the main part in the etio...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2NvxNCS
Proximity Ligation Assay (PLA).
Authors: Alam MS Abstract Proximity ligation assay (PLA), also referred to as Duolink® PLA technology, permits detection of protein-protein interactions in situ (at distances <40 nm) at endogenous protein levels. It exploits specific antibodies identifying (either directly or indirectly) the two proteins of interest and utilizes specific DNA primers covalently linked to the antibodies. A hybridization step followed by a PCR amplification with fluorescent probes permit visualization of spots of proximity by fluorescence microscopy. Since the development of PLA in 2002, it has been increasingly used to detect the interaction between two proteins with high sensitivity and specificity. It is a simple and sensitive technique to study protein-protein interaction in cells. © 2018 by...
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2NwGBIx
Opportunities for Lipid-Based Probes in the Field of Immunology.
Authors: Koenders STA, Gagestein B, van der Stelt M Abstract Lipids perform a wide range of functions inside the cell, ranging from structural building block of membranes and energy storage to cell signaling. The mode of action of many signaling lipids has remained elusive due to their low abundance, high lipophilicity, and inherent instability. Various chemical biology approaches, such as photoaffinity or activity-based protein profiling methods, have been employed to shed light on the biological role of lipids and the lipid-protein interaction profile. In this review, we will summarize the recent developments in the field of chemical probes to study lipid biology, especially in immunology, and indicate potential avenues for future research. PMID: 30242513 [PubMed - as supplie...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2DqOquL
Extracellular Vesicles in Fungi: Composition and Functions.
Authors: de Toledo Martins S, Szwarc P, Goldenberg S, Alves LR Abstract The comprehension of fungal biology is important for several reasons. Besides being used in biotechnological processes and in the food industry, fungi are also important animal and vegetal pathogens. Fungal diseases in humans have a great importance worldwide, and understanding fungal biology is crucial for treatment and prevention of these diseases, especially because of emerging antifungal resistance that poses great epidemiological risks. Communication through extracellular vesicles is a ubiquitous mechanism of molecule transfer between cells and is used to transport proteins, nucleic acids, lipids, and other biologically active molecules. Several pathogens can produce and transfer extracellular vesicles, an...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2NC8nDP
Small-Molecule Inhibitors of PARPs: From Tools for Investigating ADP-Ribosylation to Therapeutics.
Authors: Kirby IT, Cohen MS Abstract Over the last 60 years, poly-ADP-ribose polymerases (PARPs, 17 family members in humans) have emerged as important regulators of physiology and disease. Small-molecule inhibitors have been essential tools for unraveling PARP function, and recently the first PARP inhibitors have been approved for the treatment of various human cancers. However, inhibitors have only been developed for a few PARPs and in vitro profiling has revealed that many of these exhibit polypharmacology across the PARP family. In this review, we discuss the history, development, and current state of the field, highlighting the limitations and opportunities for PARP inhibitor development. PMID: 30242511 [PubMed - as supplied by publisher] (Source: Current Topics in Microb...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Dq3N6J
Can obstructive intralymphatic granulomas be the cause of cheilitis granulomatosa?
We report 6 patients with ChG who clinically presented localized edema of the lips. Lip biopsy with pathomorphological and immunohistochemical examination was performed in all cases. We found discrete, non-necrotizing granulomas which were adjacent to numerous blood and lymphatic vessels. The lumen of lymphatic channels was dilated and was either empty or contained lymph and few macrophages or was completely occluded by nearby granulomas. All patients demonstrated a characteristic pattern of lymphangiectasia and perivascular lymphatic aggregates with evidence of non-necrotizing granulomas. None manifested intralymphatic granulomas. These results do not support the view that lymphatic vessel obstruction is caused by intravascular histiocytic granulomas described as the main part in the etio...
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Ultrasound-Diagnosed Nonalcoholic Fatty Liver Disease Independently Predicts a Higher Risk of Developing Diabetes Mellitus in Nonoverweight Individuals
Publication date: Available online 23 September 2018
Source: Academic Radiology
Author(s): Liang Wang
Rationale and Objectives
This study was aimed to evaluate the independent value of ultrasound-diagnosed nonalcoholic fatty liver disease (us-NAFLD), as a surrogate imaging marker of the pathologic entity of NAFLD, in predicting incident diabetes mellitus (DM) in nonoverweight individuals.
Materials and Methods
A total of 10,064 participants who had a body mass index <23 kg/m2 were included in this retrospective cohort study. us-NAFLD was diagnosed using abdominal ultrasound. All participants were divided into subgroups according to the presence or absence of us-NAFLD and metabolic syndrome (MS).
Results
Over a mean follow-up of 6.0years, 125 participants (1.2%) developed DM. The incidence rates of DM were 1.0% in participants without us-NAFLD, 6.2% in participants with us-NAFLD, 1.1% in participants without MS, and 13.2% in participants with MS. The adjusted hazard ratios for incident DM were 2.52 (95% confidence interval:1.58–4.03) for us-NAFLD and 2.64 (95% confidence interval:1.54–4.54) for MS.
Conclusion
This study demonstrates that us-NAFLD has an independent value in predicting incident DM in non-overweight individuals.
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Raising the BAR: Challenges, Opportunities, and Hidden Gems in Radiology Education
Publication date: Available online 22 September 2018
Source: Academic Radiology
Author(s): Nicole Restauri, Rustain Morgan
Rationale and Objectives
Medical student education in radiology has long been underrepresented in the curriculum despite the increased use of imaging in clinical medicine.
Materials and Methods
The Beginning to Advanced Radiology Lab, was created with the dedicated purpose of integrating digital technology and interactive teaching methods into the UME curriculum in radiology.
Results
Results: Development of a novel educational space at the University of Colorado allowed us to identify unforeseen challenges in medical student education while exploring new opportunities
Conclusions
Conclusion: Curriculum revision in UME radiology education creates both challenges and opportunities and this paper explores these issues in the context of the current paradigm change in medical education.
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The Time to and Type of Pancreatic Cancer Recurrence after Surgical Resection: Is Prediction Possible?
Publication date: Available online 22 September 2018
Source: Academic Radiology
Author(s): Jelena Djokić Kovač, Philipp Mayer, Thilo Hackert, Miriam Klauss
Rationale and Objectives
To evaluate factors predicting pancreatic cancer recurrence, and to determine the most common appearance of tumor relapse.
Materials and Methods
Ninety patients with recurrent pancreatic cancer were retrospectively included in the study. 74.4% had pancreatic head tumors (group 1) and 25.6% pancreatic body and/or tail tumor (group 2). The tumor localization, operative technique, TNM stage, the R-status, tumor grade, lymphovascular, and perineural invasion were recorded. Location of local tumor recurrence, lymph node recurrence, or organ metastases were analyzed on the basis of follow-up CT imaging.
Results
Mean recurrence time was 17.4 ± 13.2 months. The most common recurrence type was local recurrence (84.4%), followed by lymph node (15.5%), liver (14.4%), and lung metastasis (6.7%). The predominant site of local recurrence in pancreatic head tumors was close to superior mesenteric artery, common hepatic artery, and/or celiac artery (57.4%), followed by area defined by portal vein, inferior vena cava, CA or superior mesenteric artery (31.2%). Patients with pancreatic body and/or tail carcinoma had higher incidence (p = 0.003) of metastatic disease comparing to pancreatic head tumors, while resection margin was the most common type of local tumor recurrence, seen in 46.7% cases versus 8.2% of patients with pancreatic head tumors (p < 0.001).
Conclusion
The most common recurrence type in patients with resected pancreatic carcinoma was local recurrence along cardinal arteries. The localization of primary tumor influences the type of tumor relapse and site of local recurrence.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2puzOAL
Ultrasound-Diagnosed Nonalcoholic Fatty Liver Disease Independently Predicts a Higher Risk of Developing Diabetes Mellitus in Nonoverweight Individuals
Publication date: Available online 23 September 2018
Source: Academic Radiology
Author(s): Liang Wang
Rationale and Objectives
This study was aimed to evaluate the independent value of ultrasound-diagnosed nonalcoholic fatty liver disease (us-NAFLD), as a surrogate imaging marker of the pathologic entity of NAFLD, in predicting incident diabetes mellitus (DM) in nonoverweight individuals.
Materials and Methods
A total of 10,064 participants who had a body mass index <23 kg/m2 were included in this retrospective cohort study. us-NAFLD was diagnosed using abdominal ultrasound. All participants were divided into subgroups according to the presence or absence of us-NAFLD and metabolic syndrome (MS).
Results
Over a mean follow-up of 6.0years, 125 participants (1.2%) developed DM. The incidence rates of DM were 1.0% in participants without us-NAFLD, 6.2% in participants with us-NAFLD, 1.1% in participants without MS, and 13.2% in participants with MS. The adjusted hazard ratios for incident DM were 2.52 (95% confidence interval:1.58–4.03) for us-NAFLD and 2.64 (95% confidence interval:1.54–4.54) for MS.
Conclusion
This study demonstrates that us-NAFLD has an independent value in predicting incident DM in non-overweight individuals.
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Raising the BAR: Challenges, Opportunities, and Hidden Gems in Radiology Education
Publication date: Available online 22 September 2018
Source: Academic Radiology
Author(s): Nicole Restauri, Rustain Morgan
Rationale and Objectives
Medical student education in radiology has long been underrepresented in the curriculum despite the increased use of imaging in clinical medicine.
Materials and Methods
The Beginning to Advanced Radiology Lab, was created with the dedicated purpose of integrating digital technology and interactive teaching methods into the UME curriculum in radiology.
Results
Results: Development of a novel educational space at the University of Colorado allowed us to identify unforeseen challenges in medical student education while exploring new opportunities
Conclusions
Conclusion: Curriculum revision in UME radiology education creates both challenges and opportunities and this paper explores these issues in the context of the current paradigm change in medical education.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2I9AoMG
The Time to and Type of Pancreatic Cancer Recurrence after Surgical Resection: Is Prediction Possible?
Publication date: Available online 22 September 2018
Source: Academic Radiology
Author(s): Jelena Djokić Kovač, Philipp Mayer, Thilo Hackert, Miriam Klauss
Rationale and Objectives
To evaluate factors predicting pancreatic cancer recurrence, and to determine the most common appearance of tumor relapse.
Materials and Methods
Ninety patients with recurrent pancreatic cancer were retrospectively included in the study. 74.4% had pancreatic head tumors (group 1) and 25.6% pancreatic body and/or tail tumor (group 2). The tumor localization, operative technique, TNM stage, the R-status, tumor grade, lymphovascular, and perineural invasion were recorded. Location of local tumor recurrence, lymph node recurrence, or organ metastases were analyzed on the basis of follow-up CT imaging.
Results
Mean recurrence time was 17.4 ± 13.2 months. The most common recurrence type was local recurrence (84.4%), followed by lymph node (15.5%), liver (14.4%), and lung metastasis (6.7%). The predominant site of local recurrence in pancreatic head tumors was close to superior mesenteric artery, common hepatic artery, and/or celiac artery (57.4%), followed by area defined by portal vein, inferior vena cava, CA or superior mesenteric artery (31.2%). Patients with pancreatic body and/or tail carcinoma had higher incidence (p = 0.003) of metastatic disease comparing to pancreatic head tumors, while resection margin was the most common type of local tumor recurrence, seen in 46.7% cases versus 8.2% of patients with pancreatic head tumors (p < 0.001).
Conclusion
The most common recurrence type in patients with resected pancreatic carcinoma was local recurrence along cardinal arteries. The localization of primary tumor influences the type of tumor relapse and site of local recurrence.
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Harm-reduction and zero-tolerance maternal messages about college alcohol use
Publication date: Available online 22 September 2018
Source: Addictive Behaviors
Author(s): Lucy E. Napper
Abstract
Past cross-sectional research suggests that zero-tolerance messaging by parents of college students may be more effective than harm-reduction communication at reducing student alcohol risk. The current study employs longitudinal data to examine whether communication type interacts with student alcohol use to predict subsequent drinking outcomes. U.S. college students reported on their own exposure to zero-tolerance and harm-reduction maternal communication. Approximately seven months later, students completed measures of maternal alcohol approval and their own alcohol behaviors. The relationship between communication and subsequent alcohol behaviors depended on students' baseline drinking. For heavy drinkers, harm-reduction communication was associated with less alcohol use and consequences. For those who drank less than two drinks a week, zero-tolerance communication was associated with fewer negative consequences. Zero-tolerance communication was associated with perceiving mothers as less approving, while harm reduction communication was associated with perceiving mothers as more approving. There were indirect effects of communication on drinking through perceived maternal approval. While overall harm-reduction communication may lead students to perceive mothers as more approving of alcohol use, there may be contexts in which this type of communication is beneficial.
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Harm-reduction and zero-tolerance maternal messages about college alcohol use
Publication date: Available online 22 September 2018
Source: Addictive Behaviors
Author(s): Lucy E. Napper
Abstract
Past cross-sectional research suggests that zero-tolerance messaging by parents of college students may be more effective than harm-reduction communication at reducing student alcohol risk. The current study employs longitudinal data to examine whether communication type interacts with student alcohol use to predict subsequent drinking outcomes. U.S. college students reported on their own exposure to zero-tolerance and harm-reduction maternal communication. Approximately seven months later, students completed measures of maternal alcohol approval and their own alcohol behaviors. The relationship between communication and subsequent alcohol behaviors depended on students' baseline drinking. For heavy drinkers, harm-reduction communication was associated with less alcohol use and consequences. For those who drank less than two drinks a week, zero-tolerance communication was associated with fewer negative consequences. Zero-tolerance communication was associated with perceiving mothers as less approving, while harm reduction communication was associated with perceiving mothers as more approving. There were indirect effects of communication on drinking through perceived maternal approval. While overall harm-reduction communication may lead students to perceive mothers as more approving of alcohol use, there may be contexts in which this type of communication is beneficial.
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Could the biomarker levels in saliva help distinguish between healthy implants and implants with peri-implant disease? A systematic review
Publication date: Available online 22 September 2018
Source: Archives of Oral Biology
Author(s): Alex Martins Gomes, Dhelfeson Willya Douglas-de Oliveira, Fernando Oliveira Costa
Abstract
Background
The most accurate data help to minimize possible mistakes on a patient´s evaluation, as more robust findings are necessary to establish a correct diagnosis, prognosis and, consequently, better treatment.
Purpose
Could biomarker levels in the saliva help to distinguish between healthy implants and implants with peri-implant disease?
Materials and Methods
An electronic database search of Pubmed/MEDLINE, Web of Science, the Cochrane Library, OVID and Scielo was performed. The articles and abstracts identified were considered relevant if they compared cytokine levels in saliva from patients with healthy implants to those in saliva from patients with untreated peri-implantitis.
Results
Lower salivary levels of interleukin 1β were found in healthy implants than in inflamed implants. A significantly positive correlation was found between the salivary levels of IL-6 and peri-implant inflammatory conditions. The salivary concentrations of total antioxidants, urate and ascorbate were higher in healthy implants than in inflamed implants. The data extracted from the 6 studies evaluated in this review revealed heterogeneity in relation to the clinical parameters assessed, implant restoration, bone loss and peri-implant disease definitions.
Conclusions
There was no clear, developed basis for using any specific biomarker in a clinical setting to distinguish between healthy implants and those with peri implant disease.
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Immunohistochemistry profile of p75 neurotrophin receptor in oral epithelial dysplasia and oral squamous cell carcinoma induced by 4-nitroquinoline 1-oxide in rats
Publication date: Available online 22 September 2018
Source: Archives of Oral Biology
Author(s): Marina Gabriela Teixeira Buck, Priscila Souza Cabral Tuci, Flávia Cristina Perillo Rosin, Ana Rita Pinheiro Barcessat, Luciana Corrêa
ABSTRACT
Objective
The 4-nitroquinoline 1-oxide (4-NQO) model for carcinogenesis has been used to investigate cancer stem cells (CSC), but no study has addressed the role of the p75 neurotrophin receptor (p75NTR) in 4-NQO-induced oral dysplasia and oral squamous cell carcinoma (OSCC). The aim of this study was to evaluate the immunohistochemistry profile of the p75NTR during 4-NQO-induced oral carcinogenesis in rats and to verify whether this profile has an association with proliferating cell nuclear antigen (PCNA) immunolabeling.
Design
For 28 weeks, rats were exposed to 4-NQO, which was diluted in the drinking water. After 3, 5, 7, 16, and 28 weeks, the animals were euthanized and their tongues were histologically analyzed using p75NTR and PCNA immunolabeling.
Results
In animals without 4-NQO exposure, the p75NTR and PCNA were expressed only in the basal epithelial layer and in a clustered manner. The oral epithelium showed dysplasia and a significant increase in the number of p75NTR- and PCNA-positive cells, which were localized mainly in the basal and suprabasal epithelial layers during weeks 5–16 of 4-NQO exposure. When the epithelium invaded the lamina propria and well-differentiated OSCC began, the p75NTR-positive cell frequency drastically decreased in epithelial cords and nests, showing a negative correlation with PCNA expression. p75NTR immunolabeling during 4-NQO-induced carcinogenesis was similar to that described for human head and neck dysplasia and neoplasia.
Conclusions
p75NTR immunolabeling observed in 4-NQO-induced oral dysplastic and OSCC lesions were related to the early phases of oral carcinogenesis and may help predict cell dysplasia and malignant transformation.
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Could the biomarker levels in saliva help distinguish between healthy implants and implants with peri-implant disease? A systematic review
Publication date: Available online 22 September 2018
Source: Archives of Oral Biology
Author(s): Alex Martins Gomes, Dhelfeson Willya Douglas-de Oliveira, Fernando Oliveira Costa
Abstract
Background
The most accurate data help to minimize possible mistakes on a patient´s evaluation, as more robust findings are necessary to establish a correct diagnosis, prognosis and, consequently, better treatment.
Purpose
Could biomarker levels in the saliva help to distinguish between healthy implants and implants with peri-implant disease?
Materials and Methods
An electronic database search of Pubmed/MEDLINE, Web of Science, the Cochrane Library, OVID and Scielo was performed. The articles and abstracts identified were considered relevant if they compared cytokine levels in saliva from patients with healthy implants to those in saliva from patients with untreated peri-implantitis.
Results
Lower salivary levels of interleukin 1β were found in healthy implants than in inflamed implants. A significantly positive correlation was found between the salivary levels of IL-6 and peri-implant inflammatory conditions. The salivary concentrations of total antioxidants, urate and ascorbate were higher in healthy implants than in inflamed implants. The data extracted from the 6 studies evaluated in this review revealed heterogeneity in relation to the clinical parameters assessed, implant restoration, bone loss and peri-implant disease definitions.
Conclusions
There was no clear, developed basis for using any specific biomarker in a clinical setting to distinguish between healthy implants and those with peri implant disease.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PYzk0R
Immunohistochemistry profile of p75 neurotrophin receptor in oral epithelial dysplasia and oral squamous cell carcinoma induced by 4-nitroquinoline 1-oxide in rats
Publication date: Available online 22 September 2018
Source: Archives of Oral Biology
Author(s): Marina Gabriela Teixeira Buck, Priscila Souza Cabral Tuci, Flávia Cristina Perillo Rosin, Ana Rita Pinheiro Barcessat, Luciana Corrêa
ABSTRACT
Objective
The 4-nitroquinoline 1-oxide (4-NQO) model for carcinogenesis has been used to investigate cancer stem cells (CSC), but no study has addressed the role of the p75 neurotrophin receptor (p75NTR) in 4-NQO-induced oral dysplasia and oral squamous cell carcinoma (OSCC). The aim of this study was to evaluate the immunohistochemistry profile of the p75NTR during 4-NQO-induced oral carcinogenesis in rats and to verify whether this profile has an association with proliferating cell nuclear antigen (PCNA) immunolabeling.
Design
For 28 weeks, rats were exposed to 4-NQO, which was diluted in the drinking water. After 3, 5, 7, 16, and 28 weeks, the animals were euthanized and their tongues were histologically analyzed using p75NTR and PCNA immunolabeling.
Results
In animals without 4-NQO exposure, the p75NTR and PCNA were expressed only in the basal epithelial layer and in a clustered manner. The oral epithelium showed dysplasia and a significant increase in the number of p75NTR- and PCNA-positive cells, which were localized mainly in the basal and suprabasal epithelial layers during weeks 5–16 of 4-NQO exposure. When the epithelium invaded the lamina propria and well-differentiated OSCC began, the p75NTR-positive cell frequency drastically decreased in epithelial cords and nests, showing a negative correlation with PCNA expression. p75NTR immunolabeling during 4-NQO-induced carcinogenesis was similar to that described for human head and neck dysplasia and neoplasia.
Conclusions
p75NTR immunolabeling observed in 4-NQO-induced oral dysplastic and OSCC lesions were related to the early phases of oral carcinogenesis and may help predict cell dysplasia and malignant transformation.
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Effectiveness of Audiologist-Delivered Cognitive Behavioral Therapy for Tinnitus and Hyperacusis Rehabilitation: Outcomes for Patients Treated in Routine Practice.
Conclusion: Audiologist-delivered CBT led to significant improvements in self-report measures of tinnitus and hyperacusis handicap and insomnia. The methods described here may be used when designing future randomized controlled trials of efficacy. PMID: 30242355 [PubMed - as supplied by publisher] (Source: American Journal of Audiology)
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Accuracy of Smartphone Self-Hearing Test Applications Across Frequencies and Earphone Styles in Adults.
Conclusions: Self-hearing test apps can be accurate in hearing threshold assessment and screening for mild or greater hearing loss (> 25 dB HL) when using appropriate transducers. To ensure accuracy, manufacturers should specify earphone model instructions to users of smartphone-based self-hearing test apps. PMID: 30242342 [PubMed - as supplied by publisher] (Source: American Journal of Audiology)
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Effectiveness of Audiologist-Delivered Cognitive Behavioral Therapy for Tinnitus and Hyperacusis Rehabilitation: Outcomes for Patients Treated in Routine Practice.
Conclusion: Audiologist-delivered CBT led to significant improvements in self-report measures of tinnitus and hyperacusis handicap and insomnia. The methods described here may be used when designing future randomized controlled trials of efficacy. PMID: 30242355 [PubMed - as supplied by publisher] (Source: American Journal of Audiology)
MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2N11tCU
Accuracy of Smartphone Self-Hearing Test Applications Across Frequencies and Earphone Styles in Adults.
Conclusions: Self-hearing test apps can be accurate in hearing threshold assessment and screening for mild or greater hearing loss (> 25 dB HL) when using appropriate transducers. To ensure accuracy, manufacturers should specify earphone model instructions to users of smartphone-based self-hearing test apps. PMID: 30242342 [PubMed - as supplied by publisher] (Source: American Journal of Audiology)
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Prognostic factors and survival outcomes for head and neck cutaneous adnexal cancers
Publication date: Available online 22 September 2018
Source: American Journal of Otolaryngology
Author(s): Danny B. Jandali, Ashwin Ganti, Samer Al-Khudari, Bobby A. Tajudeen, Peter C. Revenaugh
Abstract
Objectives
Malignant cutaneous adnexal tumors (MCAT) are rare and comprise a heterogeneous group of cancers. There have been several studies reviewing prognostic factors of these tumors, but no studies focusing on the head and neck. This study aimed to review a large population based database to evaluate prognostic factors that could impact survival.
Methods
The Surveillance, Epidemiology, and End Results (SEER) database was utilized to identify patients with MCAT of the head and neck. Both overall and disease specific survival were the main outcome measures for the study. Univariate and multivariate analyses were performed to evaluate the association of suspected prognostic factors with survival.
Results
The five-year OS and DSS were 72.6 and 95.5%, respectively. A favorable factor for OS was surgical resection ([HR] 0.324; P = 0.001), while unfavorable factors for OS include older age (1.051; P < 0.001), higher tumor grade (1.254; P = 0.049), larger tumor size (1.293; P = 0.003), and positive nodal involvement (3.323; P = 0.002). A favorable factor for DSS was surgical resection (0.026; P < 0.001). Unfavorable factors for DSS include older age (1.058; P = 0.046), larger tumor size (2.528; 1.565–4.085; P < 0.001), and positive nodal involvement (4.761; P = 0.022).
Conclusion
Review of the SEER database shows good 5-year OS and DSS rates, similar to those cited in other studies. We identified several prognostic factors associated with survival, while histologic sub-type does not seem to be associated with survival. Surgical resection is the mainstay of treatment.
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Prognostic factors and survival outcomes for head and neck cutaneous adnexal cancers
Publication date: Available online 22 September 2018
Source: American Journal of Otolaryngology
Author(s): Danny B. Jandali, Ashwin Ganti, Samer Al-Khudari, Bobby A. Tajudeen, Peter C. Revenaugh
Abstract
Objectives
Malignant cutaneous adnexal tumors (MCAT) are rare and comprise a heterogeneous group of cancers. There have been several studies reviewing prognostic factors of these tumors, but no studies focusing on the head and neck. This study aimed to review a large population based database to evaluate prognostic factors that could impact survival.
Methods
The Surveillance, Epidemiology, and End Results (SEER) database was utilized to identify patients with MCAT of the head and neck. Both overall and disease specific survival were the main outcome measures for the study. Univariate and multivariate analyses were performed to evaluate the association of suspected prognostic factors with survival.
Results
The five-year OS and DSS were 72.6 and 95.5%, respectively. A favorable factor for OS was surgical resection ([HR] 0.324; P = 0.001), while unfavorable factors for OS include older age (1.051; P < 0.001), higher tumor grade (1.254; P = 0.049), larger tumor size (1.293; P = 0.003), and positive nodal involvement (3.323; P = 0.002). A favorable factor for DSS was surgical resection (0.026; P < 0.001). Unfavorable factors for DSS include older age (1.058; P = 0.046), larger tumor size (2.528; 1.565–4.085; P < 0.001), and positive nodal involvement (4.761; P = 0.022).
Conclusion
Review of the SEER database shows good 5-year OS and DSS rates, similar to those cited in other studies. We identified several prognostic factors associated with survival, while histologic sub-type does not seem to be associated with survival. Surgical resection is the mainstay of treatment.
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Resolution of eosinophilia and elevated immunoglobulin E with ibrutinib for chronic lymphocytic leukemia
Publication date: Available online 22 September 2018
Source: Annals of Allergy, Asthma & Immunology
Author(s): Kaoru Harada, Joel P. Brooks, Francis M. Lobo
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Extracellular vesicle microRNA cargo is correlated with HPV‐status in oropharyngeal carcinoma
Journal of Oral Pathology &Medicine, Volume 0, Issue ja, -Not available-.
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Resolution of eosinophilia and elevated immunoglobulin E with ibrutinib for chronic lymphocytic leukemia
Publication date: Available online 22 September 2018
Source: Annals of Allergy, Asthma & Immunology
Author(s): Kaoru Harada, Joel P. Brooks, Francis M. Lobo
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Extracellular vesicle microRNA cargo is correlated with HPV‐status in oropharyngeal carcinoma
Journal of Oral Pathology &Medicine, Volume 0, Issue ja, -Not available-.
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Low resolution rates of seafood allergy
Publication date: Available online 22 September 2018
Source: The Journal of Allergy and Clinical Immunology: In Practice
Author(s): Victoria N. Zotova, Ann Elaine Clarke, Edmond S. Chan, Yuka Asai, Ricky Chin, Chynace Van Lambalgen, Laurie Harada, Moshe Ben-Shoshan
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Excision‐release of oxidatively‐induced DNA base lesions from the lung genome by cat dander extract challenge stimulates allergic airway inflammation
Clinical &Experimental Allergy, Volume 0, Issue ja, -Not available-.
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In utero exposure to cigarette smoke and effects across generations: a conference of animals on asthma
Clinical &Experimental Allergy, Volume 0, Issue ja, -Not available-.
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Bronchoscopic mucosal cryobiopsies as a method for studying airway disease
Clinical &Experimental Allergy, Volume 0, Issue ja, -Not available-.
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Low resolution rates of seafood allergy
Publication date: Available online 22 September 2018
Source: The Journal of Allergy and Clinical Immunology: In Practice
Author(s): Victoria N. Zotova, Ann Elaine Clarke, Edmond S. Chan, Yuka Asai, Ricky Chin, Chynace Van Lambalgen, Laurie Harada, Moshe Ben-Shoshan
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Excision‐release of oxidatively‐induced DNA base lesions from the lung genome by cat dander extract challenge stimulates allergic airway inflammation
Clinical &Experimental Allergy, Volume 0, Issue ja, -Not available-.
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In utero exposure to cigarette smoke and effects across generations: a conference of animals on asthma
Clinical &Experimental Allergy, Volume 0, Issue ja, -Not available-.
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Bronchoscopic mucosal cryobiopsies as a method for studying airway disease
Clinical &Experimental Allergy, Volume 0, Issue ja, -Not available-.
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Middle ear lipoma mimicking a congenital cholesteatoma: A case report and review of the literature
Publication date: Available online 22 September 2018
Source: International Journal of Pediatric Otorhinolaryngology
Author(s): Floyd Buen, Chia-Huei Chu, Akira Ishiyama
Abstract
Objective
To describe a case of middle ear lipoma, review the current literature, and discuss the surgical approach.
Methods
Published case reports in the English literature of lipomas restricted to the middle ear were reviewed. The presentation, location, and management of the middle ear lipomas were analyzed.
Results
Histological examination of the resected lesion was compatible with lipoma. Review of the literature suggests middle ear lipomas are rare and involve the epitympanum.
Conclusion
Lipomas should be included in the differential diagnosis for middle ear lesions. Adequate surgical exposure can be achieved through a transcanal approach, with particular attention to carefully elevate the tympanic membrane off the malleus, preserving the integrity of the ossicular chain.
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Does intratympanic xylitol administration have ototoxic effects in a mouse ear model?
Publication date: Available online 22 September 2018
Source: International Journal of Pediatric Otorhinolaryngology
Author(s): Eda Tuna Yalcinozan, Ebru Kösemihal, Mehmet Ates Aksit, Remzi Tinazli, Hasan Safakogullari, Kadir Cagdas Kazikdas, Mustafa Asim Safak
Abstract
Objective
To research the ototoxicity of xylitol after intratympanic injection in mice ear model.
Methods
24 female mice Balb/c mice (48 ears) included in the study. The mice were divided into 4 groups as 6 mice were found (12 ears) in each group. Solutions of 0.9 % NaCl solution (Group A), 155 mg/ml (Group B), 310 mg/ml (Group C) and 620 mg/ml (Group D) xylitol, were applied into the middle ear cavity. Microscopic ear examination and auditory brainstem response test were done for each mouse before application of xylitol and on the 1st, 3rd and 10th day of injection.
Results
There are some statistically significant alterations found in the treshold values at 8000, 12000, 16000, 24000 Hz frequencies when each group were compared in itself on day 0, 1,3 and 10, which were independent from the increasing dosage.
Conclusion
According to our findings intratympanic xylitol injection does not have any ototoxic effect in the inner ear. To evaluate the effects of xylitol more clinical studies are need to carried out.
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Association Between Symptomatic Submucous Cleft Palate and Otologic Disease: A Retrospective Review
Publication date: Available online 22 September 2018
Source: International Journal of Pediatric Otorhinolaryngology
Author(s): Adam Kwinter, Ann Dworshcak-Stokan, Josee Paradis, Murad Husein
Abstract
Introduction
Submucous cleft palate (SMCP) is the most common congenital malformation of the posterior palate and characterized in part by palatal muscle diastasis. Patients with SMCP are considered symptomatic when suffering from velopharyngeal insufficiency which leads to hypernasality of speech and excess nasal air emission. SMCP results from defects in the muscles thought to be responsible for regulating the patency of the eustachian tube which can lead to a number of middle ear pathologies and ultimately hearing loss. Hearing loss, especially at a young age, can make speech acquisition a challenge. The purpose of this study was to review patients with symptomatic SMCP (SSMCP) who have presented to our center and report on the association between SSMCP and otologic disease.
Methods
This study was a retrospective review of all patients presenting to our center between 2004 and 2016. Patients with SSMCP were identified through a patient database maintained on site. Inclusion criteria were diagnosis of SMCP and documentation of the presence or absence of otologic disease. Once identified patient records were reviewed and various demographic and patient factors were recorded. Patients were then grouped into cohorts of those with and without otologic disease and those requiring tympanostomy tubes and not. T-tests were then used to compare various factors between cohorts.
Results
A total of 73 patients were identified and 58 met inclusion criteria (mean age 5.8 years, male:female 36:22). 27.5% of patients were diagnosed with a genetic condition. 69% of patients had otologic disease and 47% required at least one set of bilateral tympanostomy myringotomy tubes. The cohort with ear disease tended to have worse scores on ACPA testing though this was not statistically significant. There were no significant demographic differences between the cohorts.
Conclusions
Patients with symptomatic SMCP suffer from a higher incidence of otologic disease and bilateral myringotomy tube placement than the general population. This is an important potential comorbidity in SSMCP patients as it can act as a further barrier to speech acquisition. Further research is needed to determine if OD can be used for prognostication or treatment purposes.
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Middle ear lipoma mimicking a congenital cholesteatoma: A case report and review of the literature
Publication date: Available online 22 September 2018
Source: International Journal of Pediatric Otorhinolaryngology
Author(s): Floyd Buen, Chia-Huei Chu, Akira Ishiyama
Abstract
Objective
To describe a case of middle ear lipoma, review the current literature, and discuss the surgical approach.
Methods
Published case reports in the English literature of lipomas restricted to the middle ear were reviewed. The presentation, location, and management of the middle ear lipomas were analyzed.
Results
Histological examination of the resected lesion was compatible with lipoma. Review of the literature suggests middle ear lipomas are rare and involve the epitympanum.
Conclusion
Lipomas should be included in the differential diagnosis for middle ear lesions. Adequate surgical exposure can be achieved through a transcanal approach, with particular attention to carefully elevate the tympanic membrane off the malleus, preserving the integrity of the ossicular chain.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Q0GGkJ
Does intratympanic xylitol administration have ototoxic effects in a mouse ear model?
Publication date: Available online 22 September 2018
Source: International Journal of Pediatric Otorhinolaryngology
Author(s): Eda Tuna Yalcinozan, Ebru Kösemihal, Mehmet Ates Aksit, Remzi Tinazli, Hasan Safakogullari, Kadir Cagdas Kazikdas, Mustafa Asim Safak
Abstract
Objective
To research the ototoxicity of xylitol after intratympanic injection in mice ear model.
Methods
24 female mice Balb/c mice (48 ears) included in the study. The mice were divided into 4 groups as 6 mice were found (12 ears) in each group. Solutions of 0.9 % NaCl solution (Group A), 155 mg/ml (Group B), 310 mg/ml (Group C) and 620 mg/ml (Group D) xylitol, were applied into the middle ear cavity. Microscopic ear examination and auditory brainstem response test were done for each mouse before application of xylitol and on the 1st, 3rd and 10th day of injection.
Results
There are some statistically significant alterations found in the treshold values at 8000, 12000, 16000, 24000 Hz frequencies when each group were compared in itself on day 0, 1,3 and 10, which were independent from the increasing dosage.
Conclusion
According to our findings intratympanic xylitol injection does not have any ototoxic effect in the inner ear. To evaluate the effects of xylitol more clinical studies are need to carried out.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2O1iKQO
Association Between Symptomatic Submucous Cleft Palate and Otologic Disease: A Retrospective Review
Publication date: Available online 22 September 2018
Source: International Journal of Pediatric Otorhinolaryngology
Author(s): Adam Kwinter, Ann Dworshcak-Stokan, Josee Paradis, Murad Husein
Abstract
Introduction
Submucous cleft palate (SMCP) is the most common congenital malformation of the posterior palate and characterized in part by palatal muscle diastasis. Patients with SMCP are considered symptomatic when suffering from velopharyngeal insufficiency which leads to hypernasality of speech and excess nasal air emission. SMCP results from defects in the muscles thought to be responsible for regulating the patency of the eustachian tube which can lead to a number of middle ear pathologies and ultimately hearing loss. Hearing loss, especially at a young age, can make speech acquisition a challenge. The purpose of this study was to review patients with symptomatic SMCP (SSMCP) who have presented to our center and report on the association between SSMCP and otologic disease.
Methods
This study was a retrospective review of all patients presenting to our center between 2004 and 2016. Patients with SSMCP were identified through a patient database maintained on site. Inclusion criteria were diagnosis of SMCP and documentation of the presence or absence of otologic disease. Once identified patient records were reviewed and various demographic and patient factors were recorded. Patients were then grouped into cohorts of those with and without otologic disease and those requiring tympanostomy tubes and not. T-tests were then used to compare various factors between cohorts.
Results
A total of 73 patients were identified and 58 met inclusion criteria (mean age 5.8 years, male:female 36:22). 27.5% of patients were diagnosed with a genetic condition. 69% of patients had otologic disease and 47% required at least one set of bilateral tympanostomy myringotomy tubes. The cohort with ear disease tended to have worse scores on ACPA testing though this was not statistically significant. There were no significant demographic differences between the cohorts.
Conclusions
Patients with symptomatic SMCP suffer from a higher incidence of otologic disease and bilateral myringotomy tube placement than the general population. This is an important potential comorbidity in SSMCP patients as it can act as a further barrier to speech acquisition. Further research is needed to determine if OD can be used for prognostication or treatment purposes.
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Medical gases
Publication date: Available online 22 September 2018
Source: Anaesthesia & Intensive Care Medicine
Author(s): William Malein, Christina Beecroft
Abstract
Understanding the complex process of production, storage and delivery of medical gases is vitally important to ensure safe and efficient practice by anaesthetists. This article discusses the medical gases commonly used in anaesthesia and intensive care, and details the journey of the commonly used medical gases from production to patient delivery. It includes core knowledge for the FRCA.
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Premedication
Publication date: Available online 22 September 2018
Source: Anaesthesia & Intensive Care Medicine
Author(s): Will Watson, Adam Capek
Abstract
Premedication is an important part of preoperative management of all patients. It involves the optimization of underlying medical conditions and implementation of risk reduction therapies. Anxiolytic medications still have a place, particularly in certain patient populations. Important classes of drugs to consider in the perioperative period are cardiovascular drugs, anticoagulants and antiplatelets. Aspiration prophylaxis is the main risk-reduction therapy used. Benzodiazepines are still the mainstay of anxiolysis treatment, while topical anaesthesia can be used to aid cannula insertion. The most important aspect is thorough assessment of each patient, and tailoring the premedication to their specific needs.
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Patient positioning in anaesthesia
Publication date: Available online 22 September 2018
Source: Anaesthesia & Intensive Care Medicine
Author(s): Dominic O'Connor, Jeremy Radcliffe
Abstract
Anaesthesia inhibits a variety of the protective mechanisms usually in place to protect us from harm and prevent damage to vulnerable tissues. In addition, anaesthesia and patient positioning may impose physiological stresses on these tissues. Patients are often required to assume positions for surgery which would be intolerable without anaesthesia; these positions may introduce hazards which can lead to injury. Positioning of patients under anaesthesia is an important subject for anaesthetists to consider, since patient positioning has implications upon the patient's physiological responses as well as potentially causing injury to the patient. We describe the considerations for the anaesthetist when positioning the surgical patient. We discuss the positions commonly used for surgical patients and relate the challenges associated with each of these positions, challenges which can be physical as well as physiological. Staffing and equipment provision levels must be adequate to cope with the complexity predicted in positioning an individual patient. The anaesthetist also needs to consider the relatively restricted access to the patient for intervention when in the prone or lateral positions.
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Spinal anaesthesia
Publication date: Available online 22 September 2018
Source: Anaesthesia & Intensive Care Medicine
Author(s): Amy LK. Sadler, Paul DW. Fettes
Abstract
Spinal anaesthesia involves the injection of local anaesthetic solution into the intrathecal space. It is a widely practiced anaesthetic technique that can provide surgical anaesthesia for procedures below the umbilicus. Due to the proximity of the central nervous system, safe practice is of paramount importance and requires a good understanding of relevant anatomy, physiology and pharmacology. Complications are rare but need to be recognized and managed rapidly and appropriately.
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Medical gases
Publication date: Available online 22 September 2018
Source: Anaesthesia & Intensive Care Medicine
Author(s): William Malein, Christina Beecroft
Abstract
Understanding the complex process of production, storage and delivery of medical gases is vitally important to ensure safe and efficient practice by anaesthetists. This article discusses the medical gases commonly used in anaesthesia and intensive care, and details the journey of the commonly used medical gases from production to patient delivery. It includes core knowledge for the FRCA.
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Does regional anaesthesia improve outcome?
Publication date: Available online 22 September 2018
Source: Anaesthesia & Intensive Care Medicine
Author(s): Kathryn Hill, Alan JR. Macfarlane
Abstract
Outcome after surgery is of interest to the patient, the surgeon and the healthcare institution. There is conclusive evidence that regional anaesthesia is associated with superior analgesic outcomes compared to opioid-based analgesic techniques and may also reduce chronic pain. While better pain control and avoiding a general anaesthetic may alone be regarded as significant outcome benefits, regional anaesthesia and analgesia may influence many other important outcomes. Regional anaesthesia clearly reduces postoperative nausea and vomiting and pulmonary complications compared to general anaesthesia. Regional anaesthesia independently reduces length of stay and is a common component of enhanced recovery packages. Contemporary, but less robust, data suggests that neuraxial anaesthesia, and to a lesser extent analgesia, may reduce blood transfusion requirements, surgical site infection, intensive care admission, cancer recurrence and maybe even mortality. Any functional outcome benefits secondary to regional anaesthesia appear to be short lived and are generally not sustained long term.
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Premedication
Publication date: Available online 22 September 2018
Source: Anaesthesia & Intensive Care Medicine
Author(s): Will Watson, Adam Capek
Abstract
Premedication is an important part of preoperative management of all patients. It involves the optimization of underlying medical conditions and implementation of risk reduction therapies. Anxiolytic medications still have a place, particularly in certain patient populations. Important classes of drugs to consider in the perioperative period are cardiovascular drugs, anticoagulants and antiplatelets. Aspiration prophylaxis is the main risk-reduction therapy used. Benzodiazepines are still the mainstay of anxiolysis treatment, while topical anaesthesia can be used to aid cannula insertion. The most important aspect is thorough assessment of each patient, and tailoring the premedication to their specific needs.
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Patient positioning in anaesthesia
Publication date: Available online 22 September 2018
Source: Anaesthesia & Intensive Care Medicine
Author(s): Dominic O'Connor, Jeremy Radcliffe
Abstract
Anaesthesia inhibits a variety of the protective mechanisms usually in place to protect us from harm and prevent damage to vulnerable tissues. In addition, anaesthesia and patient positioning may impose physiological stresses on these tissues. Patients are often required to assume positions for surgery which would be intolerable without anaesthesia; these positions may introduce hazards which can lead to injury. Positioning of patients under anaesthesia is an important subject for anaesthetists to consider, since patient positioning has implications upon the patient's physiological responses as well as potentially causing injury to the patient. We describe the considerations for the anaesthetist when positioning the surgical patient. We discuss the positions commonly used for surgical patients and relate the challenges associated with each of these positions, challenges which can be physical as well as physiological. Staffing and equipment provision levels must be adequate to cope with the complexity predicted in positioning an individual patient. The anaesthetist also needs to consider the relatively restricted access to the patient for intervention when in the prone or lateral positions.
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Spinal anaesthesia
Publication date: Available online 22 September 2018
Source: Anaesthesia & Intensive Care Medicine
Author(s): Amy LK. Sadler, Paul DW. Fettes
Abstract
Spinal anaesthesia involves the injection of local anaesthetic solution into the intrathecal space. It is a widely practiced anaesthetic technique that can provide surgical anaesthesia for procedures below the umbilicus. Due to the proximity of the central nervous system, safe practice is of paramount importance and requires a good understanding of relevant anatomy, physiology and pharmacology. Complications are rare but need to be recognized and managed rapidly and appropriately.
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Does regional anaesthesia improve outcome?
Publication date: Available online 22 September 2018
Source: Anaesthesia & Intensive Care Medicine
Author(s): Kathryn Hill, Alan JR. Macfarlane
Abstract
Outcome after surgery is of interest to the patient, the surgeon and the healthcare institution. There is conclusive evidence that regional anaesthesia is associated with superior analgesic outcomes compared to opioid-based analgesic techniques and may also reduce chronic pain. While better pain control and avoiding a general anaesthetic may alone be regarded as significant outcome benefits, regional anaesthesia and analgesia may influence many other important outcomes. Regional anaesthesia clearly reduces postoperative nausea and vomiting and pulmonary complications compared to general anaesthesia. Regional anaesthesia independently reduces length of stay and is a common component of enhanced recovery packages. Contemporary, but less robust, data suggests that neuraxial anaesthesia, and to a lesser extent analgesia, may reduce blood transfusion requirements, surgical site infection, intensive care admission, cancer recurrence and maybe even mortality. Any functional outcome benefits secondary to regional anaesthesia appear to be short lived and are generally not sustained long term.
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Inhibition of Cross-Reactive Carbohydrate Determinants in Allergy Diagnostics.
Authors: Grzywnowicz M, Majsiak E, Gaweł J, Miśkiewicz K, Doniec Z, Kurzawa R Abstract Despite being clinically largely irrelevant, antibodies against cross-reactive carbohydrate determinants (CCD) are an important issue in the in vitro diagnostics, as they may produce false positive or falsely elevated results of the immunoglobulin E class (asIgE) in relation to the actually present level of asIgE. The present chapter demonstrates an effective resolution of this diagnostic issue by the use of a CCD inhibitor in in vitro tests. A synthetic CCD inhibitor, Polycheck® CCD inhibitor, was used in the laboratory diagnostics of 24 children diagnosed with allergic diseases. The anti-CCD antibody content was measured in the serum using a Polycheck® Atopic 30-I panel (Biocheck GmbH; Mün...
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Inhibition of Cross-Reactive Carbohydrate Determinants in Allergy Diagnostics.
Authors: Grzywnowicz M, Majsiak E, Gaweł J, Miśkiewicz K, Doniec Z, Kurzawa R Abstract Despite being clinically largely irrelevant, antibodies against cross-reactive carbohydrate determinants (CCD) are an important issue in the in vitro diagnostics, as they may produce false positive or falsely elevated results of the immunoglobulin E class (asIgE) in relation to the actually present level of asIgE. The present chapter demonstrates an effective resolution of this diagnostic issue by the use of a CCD inhibitor in in vitro tests. A synthetic CCD inhibitor, Polycheck® CCD inhibitor, was used in the laboratory diagnostics of 24 children diagnosed with allergic diseases. The anti-CCD antibody content was measured in the serum using a Polycheck® Atopic 30-I panel (Biocheck GmbH; Mün...
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Legends of Allergology/Immunology: Gunnar Johansson
Allergy, Volume 0, Issue ja, -Not available-.
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Alfred William (Bill) Frankland
Allergy, Volume 0, Issue ja, -Not available-.
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Legends of Allergology/Immunology: Gunnar Johansson
Allergy, Volume 0, Issue ja, -Not available-.
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Critical appraisal of systematic reviews of executive function treatments in TBI.
CONCLUSIONS: Researchers need to identify core outcome measures to facilitate future rigorous MAs of the EF rehabilitation literature. SRs/MAs need to be conducted with thorough methods that are reported with detail. PMID: 30240277 [PubMed - as supplied by publisher] (Source: Brain Injury)
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The meaning change of hayır during the Turkish constitutional referendum 2017
Publication date: Available online 21 September 2018Source: Language SciencesAuthor(s): Johannes Woschitz, Emre YağlıAbstractHayır means both 'good' and 'no' in present-day Turkish. Hayır 'good' has been predominantly associated with a religious undertone. Recently, the Neo-Ottoman movement under the AKP has built on this connotation to promote their political ideology. In the 2017 Turkish constitutional referendum, the Turkish people decided whether they wanted to endorse this ideology: Evet (yes) meant increasing the power of the presidency and the AKP, while hayır (no) meant sustaining the competency of the parliamentary system. This led to an odd situation where a pro-democratic vote and a diametral Neo-Ottoman ideology were expressed with the same word. No-voters soon...
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The production of wh-questions in italian-speaking children with SLI.
Authors: Arosio F, Guasti MT Abstract We aim at determining whether 7-year-old Italian-speaking children with Specific Language Impairment (SLI): (1) have problems with the production of wh- questions; (2) display a subject/object asymmetry in producing which- and who questions; (3) attempt to simplify questions, especially which- questions; (4) have difficulties with movement and verbal agreement in wh- questions. We elicited subject and object who and which NP questions in 10 children with SLI (M = 7;2), in 10 chronological age (CA)-matched controls (M = 7;2) and 10 language-matched controls (M = 5;2). Results showed that (1) children with SLI produced fewer questions than both control groups; (2) a subject/object asymmetry was observed in who questions but not in which NP ...
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Success in learning similar-sounding words predicts vocabulary depth above and beyond vocabulary breadth.
Authors: VAN Goch MM, Verhoeven L, McQueen JM Abstract In lexical development, the specificity of phonological representations is important. The ability to build phonologically specific lexical representations predicts the number of words a child knows (vocabulary breadth), but it is not clear if it also fosters how well words are known (vocabulary depth). Sixty-six children were studied in kindergarten (age 5;7) and first grade (age 6;8). The predictive value of the ability to learn phonologically similar new words, phoneme discrimination ability, and phonological awareness on vocabulary breadth and depth were assessed using hierarchical regression. Word learning explained unique variance in kindergarten and first-grade vocabulary depth, over the other phonological factors. It did...
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Effects of Peer Support Interventions on the Communication of Preschoolers with Autism Spectrum Disorder: A Systematic Review.
Authors: Chapin S, McNaughton D, Boyle S, Babb S Abstract Many young children with autism spectrum disorders (ASDs) experience difficulty in the development of communication skills. Teaching peers to make use of communication support behaviors has been investigated as a strategy to increase communication for young children with ASD in early childhood settings. The purpose of this systematic review was to examine (1) the overall effects of peer support interventions on the communication of young children with ASD and (2) any possible moderating variables related to participant and intervention characteristics. The social support model was used as a framework for the study of intervention components. Eighteen single-case experimental design studies (48 children with ASD) met the incl...
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Critical appraisal of systematic reviews of executive function treatments in TBI.
CONCLUSIONS: Researchers need to identify core outcome measures to facilitate future rigorous MAs of the EF rehabilitation literature. SRs/MAs need to be conducted with thorough methods that are reported with detail. PMID: 30240277 [PubMed - as supplied by publisher] (Source: Brain Injury)
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The meaning change of hayır during the Turkish constitutional referendum 2017
Publication date: Available online 21 September 2018Source: Language SciencesAuthor(s): Johannes Woschitz, Emre YağlıAbstractHayır means both 'good' and 'no' in present-day Turkish. Hayır 'good' has been predominantly associated with a religious undertone. Recently, the Neo-Ottoman movement under the AKP has built on this connotation to promote their political ideology. In the 2017 Turkish constitutional referendum, the Turkish people decided whether they wanted to endorse this ideology: Evet (yes) meant increasing the power of the presidency and the AKP, while hayır (no) meant sustaining the competency of the parliamentary system. This led to an odd situation where a pro-democratic vote and a diametral Neo-Ottoman ideology were expressed with the same word. No-voters soon...
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The production of wh-questions in italian-speaking children with SLI.
Authors: Arosio F, Guasti MT Abstract We aim at determining whether 7-year-old Italian-speaking children with Specific Language Impairment (SLI): (1) have problems with the production of wh- questions; (2) display a subject/object asymmetry in producing which- and who questions; (3) attempt to simplify questions, especially which- questions; (4) have difficulties with movement and verbal agreement in wh- questions. We elicited subject and object who and which NP questions in 10 children with SLI (M = 7;2), in 10 chronological age (CA)-matched controls (M = 7;2) and 10 language-matched controls (M = 5;2). Results showed that (1) children with SLI produced fewer questions than both control groups; (2) a subject/object asymmetry was observed in who questions but not in which NP ...
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Success in learning similar-sounding words predicts vocabulary depth above and beyond vocabulary breadth.
Authors: VAN Goch MM, Verhoeven L, McQueen JM Abstract In lexical development, the specificity of phonological representations is important. The ability to build phonologically specific lexical representations predicts the number of words a child knows (vocabulary breadth), but it is not clear if it also fosters how well words are known (vocabulary depth). Sixty-six children were studied in kindergarten (age 5;7) and first grade (age 6;8). The predictive value of the ability to learn phonologically similar new words, phoneme discrimination ability, and phonological awareness on vocabulary breadth and depth were assessed using hierarchical regression. Word learning explained unique variance in kindergarten and first-grade vocabulary depth, over the other phonological factors. It did...
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Effects of Peer Support Interventions on the Communication of Preschoolers with Autism Spectrum Disorder: A Systematic Review.
Authors: Chapin S, McNaughton D, Boyle S, Babb S Abstract Many young children with autism spectrum disorders (ASDs) experience difficulty in the development of communication skills. Teaching peers to make use of communication support behaviors has been investigated as a strategy to increase communication for young children with ASD in early childhood settings. The purpose of this systematic review was to examine (1) the overall effects of peer support interventions on the communication of young children with ASD and (2) any possible moderating variables related to participant and intervention characteristics. The social support model was used as a framework for the study of intervention components. Eighteen single-case experimental design studies (48 children with ASD) met the incl...
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Low-frequency alternating current stimulation rhythmically suppresses gamma-band oscillations and impairs perceptual performance
Publication date: 1 January 2019
Source: NeuroImage, Volume 184
Author(s): Jim D. Herring, Sophie Esterer, Tom R. Marshall, Ole Jensen, Til O. Bergmann
Abstract
Low frequency oscillations such as alpha (8–12 Hz) are hypothesized to rhythmically gate sensory processing, reflected by 40–100 Hz gamma band activity, via the mechanism of pulsed inhibition. We applied transcranial alternating current stimulation (TACS) at individual alpha frequency (IAF) and flanking frequencies (IAF-4 Hz, IAF+4 Hz) to the occipital cortex of healthy human volunteers during concurrent magnetoencephalography (MEG), while participants performed a visual detection task inducing strong gamma-band responses. Occipital (but not retinal) TACS phasically suppressed stimulus-induced gamma oscillations in the visual cortex and impaired target detection, with stronger phase-to-amplitude coupling predicting behavioral impairments. Retinal control TACS ruled out retino-thalamo-cortical entrainment resulting from (subthreshold) retinal stimulation. All TACS frequencies tested were effective, suggesting that visual gamma-band responses can be modulated by a range of low frequency oscillations. We propose that TACS-induced membrane potential modulations mimic the rhythmic change in cortical excitability by which spontaneous low frequency oscillations may eventually exert their impact when gating sensory processing via pulsed inhibition.
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Low-frequency alternating current stimulation rhythmically suppresses gamma-band oscillations and impairs perceptual performance
Publication date: 1 January 2019
Source: NeuroImage, Volume 184
Author(s): Jim D. Herring, Sophie Esterer, Tom R. Marshall, Ole Jensen, Til O. Bergmann
Abstract
Low frequency oscillations such as alpha (8–12 Hz) are hypothesized to rhythmically gate sensory processing, reflected by 40–100 Hz gamma band activity, via the mechanism of pulsed inhibition. We applied transcranial alternating current stimulation (TACS) at individual alpha frequency (IAF) and flanking frequencies (IAF-4 Hz, IAF+4 Hz) to the occipital cortex of healthy human volunteers during concurrent magnetoencephalography (MEG), while participants performed a visual detection task inducing strong gamma-band responses. Occipital (but not retinal) TACS phasically suppressed stimulus-induced gamma oscillations in the visual cortex and impaired target detection, with stronger phase-to-amplitude coupling predicting behavioral impairments. Retinal control TACS ruled out retino-thalamo-cortical entrainment resulting from (subthreshold) retinal stimulation. All TACS frequencies tested were effective, suggesting that visual gamma-band responses can be modulated by a range of low frequency oscillations. We propose that TACS-induced membrane potential modulations mimic the rhythmic change in cortical excitability by which spontaneous low frequency oscillations may eventually exert their impact when gating sensory processing via pulsed inhibition.
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Surgical Excision of the Submandibular Gland
Publication date: Available online 22 September 2018
Source: Operative Techniques in Otolaryngology-Head and Neck Surgery
Author(s): Travis P. Schrank, Yana Mikhaylov, Adam M. Zanation
Abstract
A variety of pathology commonly affects the salivary glands including both benign and malignant tumors as well as infectious and inflammatory disease. Although newer techniques including sialo-endoscopy are emerging for the treatment of inflammatory and obstructive disorders, excision of the submandibular gland remains the treatment of choice for tumors of the submandibular gland and remains an important option for the treatment of refractory inflammatory disease. Relevant surgical anatomy, perioperative management, surgical technique, and possible complications are discussed.
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Deep Lobe Parotidectomy
Publication date: Available online 22 September 2018
Source: Operative Techniques in Otolaryngology-Head and Neck Surgery
Author(s): Kathryn M. Van Abel, Kerry D. Olsen
Abstract
Deep lobe parotidectomy (DLP) is a critical procedure to master for any head and neck oncologic surgeon. This procedure is indicated for any deep lobe malignancy, a superficial lobe malignancy with extension into the deep lobe, refractory inflammatory conditions, and the presence of metastatic disease within a superficial or periparotid lymph node. This article describes the relevant anatomy and steps required to perform a DLP with and without facial nerve sacrifice. In addition, the history of the procedure, patient work up, indications, and possible complications are discussed.
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Identification and Dissection of the Facial Nerve During Parotidectomy
Publication date: Available online 22 September 2018
Source: Operative Techniques in Otolaryngology-Head and Neck Surgery
Author(s): Guy J. Petruzzelli
Abstract
Facial nerve injury during parotidectomy remains one of the most significant complications associated this operation. Preventing facial nerve injury begins with a detailed understanding of the extra-temporal course of the facial nerve beginning with identification of the main trunk at the stylomastoid foramen. Reliable anatomic landmarks are present which facilitate identification and preservation of the main trunk of the facial nerve and facilitate antegrade dissection and preservation of the facial nerve distally. This article reviews the skeletal, cartilaginous, and muscular landmarks necessary for the reliable identification of the main trunk of the facial nerve during parotid surgery. Meticulous identification of these landmarks and attention to surgical detail we'll facilitate safe identification and dissection of the facial nerve and contributes significantly to successful parotid surgery.
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Surgical Excision of the Submandibular Gland
Publication date: Available online 22 September 2018
Source: Operative Techniques in Otolaryngology-Head and Neck Surgery
Author(s): Travis P. Schrank, Yana Mikhaylov, Adam M. Zanation
Abstract
A variety of pathology commonly affects the salivary glands including both benign and malignant tumors as well as infectious and inflammatory disease. Although newer techniques including sialo-endoscopy are emerging for the treatment of inflammatory and obstructive disorders, excision of the submandibular gland remains the treatment of choice for tumors of the submandibular gland and remains an important option for the treatment of refractory inflammatory disease. Relevant surgical anatomy, perioperative management, surgical technique, and possible complications are discussed.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2QPYzDT
Deep Lobe Parotidectomy
Publication date: Available online 22 September 2018
Source: Operative Techniques in Otolaryngology-Head and Neck Surgery
Author(s): Kathryn M. Van Abel, Kerry D. Olsen
Abstract
Deep lobe parotidectomy (DLP) is a critical procedure to master for any head and neck oncologic surgeon. This procedure is indicated for any deep lobe malignancy, a superficial lobe malignancy with extension into the deep lobe, refractory inflammatory conditions, and the presence of metastatic disease within a superficial or periparotid lymph node. This article describes the relevant anatomy and steps required to perform a DLP with and without facial nerve sacrifice. In addition, the history of the procedure, patient work up, indications, and possible complications are discussed.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2xJ6Ctr
Identification and Dissection of the Facial Nerve During Parotidectomy
Publication date: Available online 22 September 2018
Source: Operative Techniques in Otolaryngology-Head and Neck Surgery
Author(s): Guy J. Petruzzelli
Abstract
Facial nerve injury during parotidectomy remains one of the most significant complications associated this operation. Preventing facial nerve injury begins with a detailed understanding of the extra-temporal course of the facial nerve beginning with identification of the main trunk at the stylomastoid foramen. Reliable anatomic landmarks are present which facilitate identification and preservation of the main trunk of the facial nerve and facilitate antegrade dissection and preservation of the facial nerve distally. This article reviews the skeletal, cartilaginous, and muscular landmarks necessary for the reliable identification of the main trunk of the facial nerve during parotid surgery. Meticulous identification of these landmarks and attention to surgical detail we'll facilitate safe identification and dissection of the facial nerve and contributes significantly to successful parotid surgery.
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Peripheral group 2 innate lymphoid cells are decreased following nasal allergen challenge in allergic rhinitis
Allergy, Volume 0, Issue ja, -Not available-.
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Breathing pattern disorderin difficult asthma: characteristics and improvement in asthma control and quality of life after breathing re‐training
Allergy, Volume 0, Issue ja, -Not available-.
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Long‐term exposure to neighborhood smoke from household heating and risk of respiratory and dermatological prescription medications ‐ Growing Up in New Zealand child cohort study
Allergy, Volume 0, Issue ja, -Not available-.
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The 2016 Melbourne thunderstorm asthma epidemic: risk factors for severe attacks requiring hospital admission
Allergy, Volume 0, Issue ja, -Not available-.
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Latest News on relationship between thunderstorms and respiratory allergy, severe asthma, and deaths for asthma
Allergy, Volume 0, Issue ja, -Not available-.
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Peripheral group 2 innate lymphoid cells are decreased following nasal allergen challenge in allergic rhinitis
Allergy, Volume 0, Issue ja, -Not available-.
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Breathing pattern disorderin difficult asthma: characteristics and improvement in asthma control and quality of life after breathing re‐training
Allergy, Volume 0, Issue ja, -Not available-.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2xKjEqD
Long‐term exposure to neighborhood smoke from household heating and risk of respiratory and dermatological prescription medications ‐ Growing Up in New Zealand child cohort study
Allergy, Volume 0, Issue ja, -Not available-.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2QSWUgL
The 2016 Melbourne thunderstorm asthma epidemic: risk factors for severe attacks requiring hospital admission
Allergy, Volume 0, Issue ja, -Not available-.
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Latest News on relationship between thunderstorms and respiratory allergy, severe asthma, and deaths for asthma
Allergy, Volume 0, Issue ja, -Not available-.
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Potential cofactors in accidental food allergic reactions are frequently present but may not influence severity and occurrence
Clinical &Experimental Allergy, Volume 0, Issue ja, -Not available-.
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