Retired Cronulla star Luke Lewis says Shane Flanagan's de-registration won't tarnish his drought-breaking 2016 NRL premiership.
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Παρασκευή 21 Δεκεμβρίου 2018
Saga won't tarnish Flanagan's Cronulla premiership: Lewis - The Sydney Morning Herald
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A Multi-Factorial Assessment of Elite Paratriathletes' Response to Two Weeks of Intensified Training.
CONCLUSIONS:: There was little to no change in parameters commonly associated with the fatigued state which may relate to the training camp setting minimising external life stresses and the careful management of training loads from coaches. This is the first evidence of such responses in Paralympic athletes. PMID: 30569793 [PubMed - as supplied by publisher] (Source: International Journal of Sports Physiology and Performance)
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Epigenome-wide Meta-analysis of DNA Methylation and Childhood Asthma
This large-scale genome-wide meta-analysis identified variation in DNA methylation related to childhood asthma, prospectively in newborns and cross-sectionally in children; these biomarkers of asthma development and biologic effects that may shed light on disease mechanisms. (Source: Journal of Allergy and Clinical Immunology)
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Saga won't tarnish Flanagan's Cronulla premiership: Lewis - The Sydney Morning Herald
Retired Cronulla star Luke Lewis says Shane Flanagan's de-registration won't tarnish his drought-breaking 2016 NRL premiership.
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A Multi-Factorial Assessment of Elite Paratriathletes' Response to Two Weeks of Intensified Training.
CONCLUSIONS:: There was little to no change in parameters commonly associated with the fatigued state which may relate to the training camp setting minimising external life stresses and the careful management of training loads from coaches. This is the first evidence of such responses in Paralympic athletes. PMID: 30569793 [PubMed - as supplied by publisher] (Source: International Journal of Sports Physiology and Performance)
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Epigenome-wide Meta-analysis of DNA Methylation and Childhood Asthma
This large-scale genome-wide meta-analysis identified variation in DNA methylation related to childhood asthma, prospectively in newborns and cross-sectionally in children; these biomarkers of asthma development and biologic effects that may shed light on disease mechanisms. (Source: Journal of Allergy and Clinical Immunology)
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Non‐syndromic cleft lip with or without palate susceptible loci are associated with tooth agenesis
Abstract
Objective
Non‐syndromic tooth agenesis (NSTA) may share common genetic factors with non‐syndromic cleft lip with or without cleft palate (NSCL/P). Single nucleotide polymorphisms (SNPs) were associated with individual's susceptibility to these anomalies. We selected five NSCL/P‐associated SNPs from our previous genome‐wide association study (GWAS) to test for the associations with NSTA.
Materials and methods
677 NSTA cases and 1,144 healthy controls were recruited in this case‐control study. Five genome‐wide NSCL/P‐associated SNPs (rs2235371, rs7078160, rs8049367, rs4791774 and rs13041247) were genotyped by TaqMan platform and evaluated for the associations with NSTA using PLINK software.
Results
No significant associations between these SNPs and risk of NSTA were observed in the overall analysis and subgroup analysis with the number of missing teeth. However, in the subgroup analysis by tooth position, rs8049367 was nominally associated with mandibular premolar agenesis (Dominant model: ORdom=0.66, 95% CIdom=0.47‐0.93, P dom=0.016; Heterozygote model: ORhet=0.60, 95% CIhet=0.41‐0.88, P het=0.008). Rs4791774 showed a nominal association with congenitally missing maxillary canine (Dominant model: ORdom=0.53, 95% CIdom=0.28‐0.98, P dom=0.041; Heterozygote model: ORhet=0.50, 95% CIhet=0.26‐0.97, P het=0.041) and premolar (Additive model: OR=0.59, 95% CI=0.36‐0.96, P=0.035).
Conclusion
This study showed that NSCL/P susceptible loci rs8049367 and rs4791774 were probably associated with risk of NSTA.
This article is protected by copyright. All rights reserved.
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Non‐syndromic cleft lip with or without palate susceptible loci are associated with tooth agenesis
Abstract
Objective
Non‐syndromic tooth agenesis (NSTA) may share common genetic factors with non‐syndromic cleft lip with or without cleft palate (NSCL/P). Single nucleotide polymorphisms (SNPs) were associated with individual's susceptibility to these anomalies. We selected five NSCL/P‐associated SNPs from our previous genome‐wide association study (GWAS) to test for the associations with NSTA.
Materials and methods
677 NSTA cases and 1,144 healthy controls were recruited in this case‐control study. Five genome‐wide NSCL/P‐associated SNPs (rs2235371, rs7078160, rs8049367, rs4791774 and rs13041247) were genotyped by TaqMan platform and evaluated for the associations with NSTA using PLINK software.
Results
No significant associations between these SNPs and risk of NSTA were observed in the overall analysis and subgroup analysis with the number of missing teeth. However, in the subgroup analysis by tooth position, rs8049367 was nominally associated with mandibular premolar agenesis (Dominant model: ORdom=0.66, 95% CIdom=0.47‐0.93, P dom=0.016; Heterozygote model: ORhet=0.60, 95% CIhet=0.41‐0.88, P het=0.008). Rs4791774 showed a nominal association with congenitally missing maxillary canine (Dominant model: ORdom=0.53, 95% CIdom=0.28‐0.98, P dom=0.041; Heterozygote model: ORhet=0.50, 95% CIhet=0.26‐0.97, P het=0.041) and premolar (Additive model: OR=0.59, 95% CI=0.36‐0.96, P=0.035).
Conclusion
This study showed that NSCL/P susceptible loci rs8049367 and rs4791774 were probably associated with risk of NSTA.
This article is protected by copyright. All rights reserved.
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Epigenome-wide Meta-analysis of DNA Methylation and Childhood Asthma
This large-scale genome-wide meta-analysis identified variation in DNA methylation related to childhood asthma, prospectively in newborns and cross-sectionally in children; these biomarkers of asthma development and biologic effects that may shed light on disease mechanisms. (Source: Journal of Allergy and Clinical Immunology)
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Epigenome-wide Meta-analysis of DNA Methylation and Childhood Asthma
This large-scale genome-wide meta-analysis identified variation in DNA methylation related to childhood asthma, prospectively in newborns and cross-sectionally in children; these biomarkers of asthma development and biologic effects that may shed light on disease mechanisms. (Source: Journal of Allergy and Clinical Immunology)
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Identifying features of apps to support using evidence-based language intervention with children.
This study investigated the features of apps that speech-language pathologists (SLPs) deem to be beneficial for language intervention with children. The study employed an explanatory, sequential mixed-method approach. A self-developed online survey was distributed to SLPs (n = 338) who use apps. This was followed by a semi-structured interview with some participants (n = 16) in order to obtain further insights from the survey. The findings indicated that SLPs view apps as an engaging and motivating tool for therapy to facilitate their intervention goals. Specific content and design features of apps may support effective language intervention. However, these features need to be carefully evaluated in terms of the underlying principles of language intervention, multimedia learning, and lea...
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Identifying features of apps to support using evidence-based language intervention with children.
This study investigated the features of apps that speech-language pathologists (SLPs) deem to be beneficial for language intervention with children. The study employed an explanatory, sequential mixed-method approach. A self-developed online survey was distributed to SLPs (n = 338) who use apps. This was followed by a semi-structured interview with some participants (n = 16) in order to obtain further insights from the survey. The findings indicated that SLPs view apps as an engaging and motivating tool for therapy to facilitate their intervention goals. Specific content and design features of apps may support effective language intervention. However, these features need to be carefully evaluated in terms of the underlying principles of language intervention, multimedia learning, and lea...
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'Devastation': Freak storm strikes family farm after drought and illness - Central Western Daily
'Devastation': Freak storm strikes family farm after drought and illness Central Western Daily
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The Johnstones were hit by a 'cyclone' type freak storm on Thursday.
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Saga won't tarnish Flanagan's Cronulla premiership: Lewis - The Sydney Morning Herald
Retired Cronulla star Luke Lewis says Shane Flanagan's de-registration won't tarnish his drought-breaking 2016 NRL premiership.
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Info integrity: Check your medical records for dangerous errors - Daily Comet
Info integrity: Check your medical records for dangerous errors Daily Comet
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When Liz Tidyman's elderly parents moved across the country to be closer to their children and grandchildren years ago, they carried their medical records with ...
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Merck KGaA, Darmstadt, Germany, and Pfizer Provide Update on JAVELIN Ovarian 100 Trial of Avelumab in Previously Untreated Advanced Ovarian Cancer - PRNewswire
Merck KGaA, Darmstadt, Germany, and Pfizer Provide Update on JAVELIN Ovarian 100 Trial of Avelumab in Previously Untreated Advanced Ovarian Cancer PRNewswire
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DARMSTADT, Germany, and NEW YORK, December 21, 2018 /PRNewswire/ -- Not intended for UK-based media Merck KGaA, Darmstadt, Germany, and Pfizer ...
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'Devastation': Freak storm strikes family farm after drought and illness - Central Western Daily
'Devastation': Freak storm strikes family farm after drought and illness Central Western Daily
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The Johnstones were hit by a 'cyclone' type freak storm on Thursday.
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Saga won't tarnish Flanagan's Cronulla premiership: Lewis - The Sydney Morning Herald
Retired Cronulla star Luke Lewis says Shane Flanagan's de-registration won't tarnish his drought-breaking 2016 NRL premiership.
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Info integrity: Check your medical records for dangerous errors - Daily Comet
Info integrity: Check your medical records for dangerous errors Daily Comet
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When Liz Tidyman's elderly parents moved across the country to be closer to their children and grandchildren years ago, they carried their medical records with ...
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Merck KGaA, Darmstadt, Germany, and Pfizer Provide Update on JAVELIN Ovarian 100 Trial of Avelumab in Previously Untreated Advanced Ovarian Cancer - PRNewswire
Merck KGaA, Darmstadt, Germany, and Pfizer Provide Update on JAVELIN Ovarian 100 Trial of Avelumab in Previously Untreated Advanced Ovarian Cancer PRNewswire
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DARMSTADT, Germany, and NEW YORK, December 21, 2018 /PRNewswire/ -- Not intended for UK-based media Merck KGaA, Darmstadt, Germany, and Pfizer ...
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Follicular Thyroid Cancer Drug Market Competition, Status and Forecast, Market Size by Players, Regions, Type, Application by 2025 - NMSU Rеpоrt
Follicular Thyroid Cancer Drug Market Report covers the manufacturers data, including: shipment, price, revenue, gross profit, interview record, business ...
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Follicular Thyroid Cancer Drug Market Competition, Status and Forecast, Market Size by Players, Regions, Type, Application by 2025 - NMSU Rеpоrt
Follicular Thyroid Cancer Drug Market Report covers the manufacturers data, including: shipment, price, revenue, gross profit, interview record, business ...
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The utility of DECT in focal thyroid lesions | Head & Neck - MD Linx
The utility of DECT in focal thyroid lesions | Head & Neck MD Linx
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Internal Medicine Article: Dual-energy CT iodine quantification for characterizing focal thyroid lesions.
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Fall that broke Ruth Bader Ginsburg's ribs may have saved Supreme Court justice's life - NBC News
Doctors examining Supreme Court Justice Ruth Bader Ginsburg's broken ribs from a fall on Nov. 7 were able to discover cancer in her lungs in time to treat it.
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”F cancer, I’m going skiing” - SNEWS
Beloved PR guy, John DiCuollo of Backbone Media, is fighting Hodgkins Lymphoma the only way he knows how: by staying positive and carving turns.
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Effects of Soluble Tumor Necrosis Factor (TNF) on Antibody-Dependent Cellular Cytotoxicity of Therapeutic anti-TNF- α Antibody.
In this study, we established a new stable effector cell line expressing human FcγRIIIa, CD16:KHYG-1, and compared the performance of this cell line with that of peripheral blood mononuclear cells (PBMCs) in ADCC assays against CHO-derived target cells expressing protease-sensitive pro-TNF. Although an inhibitory effect of soluble TNF released from pro-TNF expressing cells on ADCC activity was seen, clear dose-responsive ADCC activities were observed even in the presence or absence of TNF-α converting enzyme (TACE) inhibitor. However, significant differences in the ADCC activities in the presence or absence of TACE inhibitor were only noted when CD16:KHYG-1 cells were used as the effector cells. Our findings indicate that soluble TNF may influence ADCC activity of anti-TNF antibody. More...
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New challenges in integrated diagnosis by imaging and osteo-immunology in bone lesions.
Authors: Schiano C, Soricelli A, de Nigris F, Napoli C Abstract INTRODUCTION: High-resolution imaging is the gold standard to measure the functional and biological features of bone lesions. Imaging markers have allowed the characterization both of tumour heterogeneity and metabolic data. Besides, ongoing studies are evaluating a combined use of "imaging markers", such as SUVs, MATV, TLG, ADC from PET and MRI techniques respectively, and several "biomarkers" spanning from chemokine immune-modulators, such as PD-1, RANK/RANKL, CXCR4/CXCL12 to transcription factors, such as TP53, RB1, MDM2, RUNX family, EZH2, YY1, MAD2. Osteoimmunology may improve diagnosis and prognosis leading to precision medicine in bone lesion treatment. Areas covered: We investigated modalities (molecular and im...
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New challenges in integrated diagnosis by imaging and osteo-immunology in bone lesions.
Authors: Schiano C, Soricelli A, de Nigris F, Napoli C Abstract INTRODUCTION: High-resolution imaging is the gold standard to measure the functional and biological features of bone lesions. Imaging markers have allowed the characterization both of tumour heterogeneity and metabolic data. Besides, ongoing studies are evaluating a combined use of "imaging markers", such as SUVs, MATV, TLG, ADC from PET and MRI techniques respectively, and several "biomarkers" spanning from chemokine immune-modulators, such as PD-1, RANK/RANKL, CXCR4/CXCL12 to transcription factors, such as TP53, RB1, MDM2, RUNX family, EZH2, YY1, MAD2. Osteoimmunology may improve diagnosis and prognosis leading to precision medicine in bone lesion treatment. Areas covered: We investigated modalities (molecular and im...
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From mother to baby: antenatal exposure to monoclonal antibody biologics.
We describe the potential risks of infections and reported hematological and immunological effects of antenatal mAbs exposure on the infant and provide guidance on the management of the exposed infant. Expert opinion: Exposed infants should be monitored closely. Certain mAb exposures require specific testing and management. Safety monitoring should be done in a multidisciplinary approach and should include pediatric care providers. The current clinical experience with anti-tumor necrosis factor agents in pregnancy cannot be extrapolated to other mAbs. Long term observational studies and a multicenter international registry are needed to better appreciate the impact of exposure, especially to newer mAbs. PMID: 30570400 [PubMed - as supplied by publisher] (Source: Expert Review of Clinic...
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From mother to baby: antenatal exposure to monoclonal antibody biologics.
We describe the potential risks of infections and reported hematological and immunological effects of antenatal mAbs exposure on the infant and provide guidance on the management of the exposed infant. Expert opinion: Exposed infants should be monitored closely. Certain mAb exposures require specific testing and management. Safety monitoring should be done in a multidisciplinary approach and should include pediatric care providers. The current clinical experience with anti-tumor necrosis factor agents in pregnancy cannot be extrapolated to other mAbs. Long term observational studies and a multicenter international registry are needed to better appreciate the impact of exposure, especially to newer mAbs. PMID: 30570400 [PubMed - as supplied by publisher] (Source: Expert Review of Clinic...
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Effects of Soluble Tumor Necrosis Factor (TNF) on Antibody-Dependent Cellular Cytotoxicity of Therapeutic anti-TNF- α Antibody.
In this study, we established a new stable effector cell line expressing human FcγRIIIa, CD16:KHYG-1, and compared the performance of this cell line with that of peripheral blood mononuclear cells (PBMCs) in ADCC assays against CHO-derived target cells expressing protease-sensitive pro-TNF. Although an inhibitory effect of soluble TNF released from pro-TNF expressing cells on ADCC activity was seen, clear dose-responsive ADCC activities were observed even in the presence or absence of TNF-α converting enzyme (TACE) inhibitor. However, significant differences in the ADCC activities in the presence or absence of TACE inhibitor were only noted when CD16:KHYG-1 cells were used as the effector cells. Our findings indicate that soluble TNF may influence ADCC activity of anti-TNF antibody. More...
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”F cancer, I’m going skiing” - SNEWS
Beloved PR guy, John DiCuollo of Backbone Media, is fighting Hodgkins Lymphoma the only way he knows how: by staying positive and carving turns.
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Global Head and Neck Cancer Diagnostics Market Outlook 2023: Market Trends, Segmentation, Market Growth and Competitive Landscape - Latest Biz News
Global Head and Neck Cancer Diagnostics Market Outlook 2023: Market Trends, Segmentation, Market Growth and Competitive Landscape Latest Biz News
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Global Head and Neck Cancer Diagnostics Market 2018 report profit smartly substantial competitor info, investigation, and tips to invent effective RD plans and ...
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Global Head and Neck Cancer Diagnostics Market Outlook 2023: Market Trends, Segmentation, Market Growth and Competitive Landscape - Latest Biz News
Global Head and Neck Cancer Diagnostics Market Outlook 2023: Market Trends, Segmentation, Market Growth and Competitive Landscape Latest Biz News
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Global Head and Neck Cancer Diagnostics Market 2018 report profit smartly substantial competitor info, investigation, and tips to invent effective RD plans and ...
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Rakuten Aspyrian Closes $284 Million Series C Financing for Late-Stage Oncology Pipeline - BioSpace
Published: Dec 21, 2018. SAN FRANCISCO, Dec. 20, 2018 /PRNewswire/ -- Rakuten Aspyrian, a biotechnology company developing precision-targeted cancer ...
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Rakuten Aspyrian Closes $284 Million Series C Financing for Late-Stage Oncology Pipeline - BioSpace
Published: Dec 21, 2018. SAN FRANCISCO, Dec. 20, 2018 /PRNewswire/ -- Rakuten Aspyrian, a biotechnology company developing precision-targeted cancer ...
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Head and Neck Cancer Treatment Market Analysis, Latest Trends and Regional Growth Forecast by Types and Applications 2017 - Dacca Times
Head and Neck Cancer Treatment Market research report 2017 delivers a holistic vision of the global market also analyze the current industry state, demands, ...
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Poly Polymerase 2 Market 2018-2025 Trends, Drivers, Strategies, Applications and Competitive Landscape - The Daily Journal
Poly Polymerase 2 market report provides an overview of industry on by analysing revenue, cost, gross, gross margin, growth rate, consumption, import, export, ...
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Obesity to Blame for Almost 1 in 25 Cancers Worldwide - U.S. News & World Report
Obesity to Blame for Almost 1 in 25 Cancers Worldwide U.S. News & World Report
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By Robert Preidt, HealthDay Reporter. (HealthDay). WEDNESDAY, Dec. 12, 2018 (HealthDay News) -- Overweight and obesity accounted for nearly 4 percent of ...
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Head and Neck Cancer Treatment Market Analysis, Latest Trends and Regional Growth Forecast by Types and Applications 2017 - Dacca Times
Head and Neck Cancer Treatment Market research report 2017 delivers a holistic vision of the global market also analyze the current industry state, demands, ...
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Poly Polymerase 2 Market 2018-2025 Trends, Drivers, Strategies, Applications and Competitive Landscape - The Daily Journal
Poly Polymerase 2 market report provides an overview of industry on by analysing revenue, cost, gross, gross margin, growth rate, consumption, import, export, ...
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Obesity to Blame for Almost 1 in 25 Cancers Worldwide - U.S. News & World Report
Obesity to Blame for Almost 1 in 25 Cancers Worldwide U.S. News & World Report
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By Robert Preidt, HealthDay Reporter. (HealthDay). WEDNESDAY, Dec. 12, 2018 (HealthDay News) -- Overweight and obesity accounted for nearly 4 percent of ...
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Funky Chunky, Llc Issues Allergy Alert on Undeclared Almond and Cashew Tree-Nut in 10 Oz. Nutty Choco Pop Found in Chocolate Popcorn Gift Box, Holiday Crowd Pleaser and Crowd Pleaser Gifts
Funky Chunky, LLC of Eden Prairie, MN is recalling 10 oz Nutty Choco Pop Gift Box, 50 oz. Holiday Crowd Pleaser and 50 oz. Crowd Pleaser, because it may contain undeclared Almond and Cashew Tree Nut. People who have an allergy or severe sensitivity to Almonds and Cashews run the risk of serious or life-threatening allergic reaction if they consume these products. (Source: Food and Drug Administration)
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Funky Chunky, Llc Issues Allergy Alert on Undeclared Almond and Cashew Tree-Nut in 10 Oz. Nutty Choco Pop Found in Chocolate Popcorn Gift Box, Holiday Crowd Pleaser and Crowd Pleaser Gifts
Funky Chunky, LLC of Eden Prairie, MN is recalling 10 oz Nutty Choco Pop Gift Box, 50 oz. Holiday Crowd Pleaser and 50 oz. Crowd Pleaser, because it may contain undeclared Almond and Cashew Tree Nut. People who have an allergy or severe sensitivity to Almonds and Cashews run the risk of serious or life-threatening allergic reaction if they consume these products. (Source: Food and Drug Administration)
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Funky Chunky, Llc Issues Allergy Alert on Undeclared Almond and Cashew Tree-Nut in 10 Oz. Nutty Choco Pop Found in Chocolate Popcorn Gift Box, Holiday Crowd Pleaser and Crowd Pleaser Gifts
Funky Chunky, LLC of Eden Prairie, MN is recalling 10 oz Nutty Choco Pop Gift Box, 50 oz. Holiday Crowd Pleaser and 50 oz. Crowd Pleaser, because it may contain undeclared Almond and Cashew Tree Nut. People who have an allergy or severe sensitivity to Almonds and Cashews run the risk of serious or life-threatening allergic reaction if they consume these products. (Source: Food and Drug Administration)
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Funky Chunky, Llc Issues Allergy Alert on Undeclared Almond and Cashew Tree-Nut in 10 Oz. Nutty Choco Pop Found in Chocolate Popcorn Gift Box, Holiday Crowd Pleaser and Crowd Pleaser Gifts
Funky Chunky, LLC of Eden Prairie, MN is recalling 10 oz Nutty Choco Pop Gift Box, 50 oz. Holiday Crowd Pleaser and 50 oz. Crowd Pleaser, because it may contain undeclared Almond and Cashew Tree Nut. People who have an allergy or severe sensitivity to Almonds and Cashews run the risk of serious or life-threatening allergic reaction if they consume these products. (Source: Food and Drug Administration)
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Response Genetics (OTCMKTS:RGDXQ) versus Lantheus (LNTH) Financial Survey - Fairfield Current
Response Genetics (OTCMKTS:RGDXQ) and Lantheus (NASDAQ:LNTH) are both small-cap medical companies, but which is the superior investment? We will ...
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Follicular Thyroid Cancer Drug Market Competition, Status and Forecast, Market Size by Players, Regions, Type, Application by 2025 - The Lansing Post
Follicular Thyroid Cancer Drug Market Report covers the manufacturers data, including: shipment, price, revenue, gross profit, interview record, business ...
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Cancer teenager’s dream Disney holiday - Yorkshire Evening Post
Cancer teenager's dream Disney holiday Yorkshire Evening Post
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A teenager stricken with cancer, that affects other members of his family too, has enjoyed a fantastic holiday in Florida.
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Global Head and Neck Cancer Market Analysis Outlook 2027 - The Business Hours
Global Head and Neck Cancer Market Analysis Outlook 2027 The Business Hours
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"The research study Head and Neck Cancer Market Global Trends, Growth, Size, status and Forecast 2027†is that the latest report added to the big market ...
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Follicular Thyroid Cancer Drug Market Competition, Status and Forecast, Market Size by Players, Regions, Type, Application by 2025 - The Lansing Post
Follicular Thyroid Cancer Drug Market Report covers the manufacturers data, including: shipment, price, revenue, gross profit, interview record, business ...
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Cancer teenager’s dream Disney holiday - Yorkshire Evening Post
Cancer teenager's dream Disney holiday Yorkshire Evening Post
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A teenager stricken with cancer, that affects other members of his family too, has enjoyed a fantastic holiday in Florida.
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Global Head and Neck Cancer Market Analysis Outlook 2027 - The Business Hours
Global Head and Neck Cancer Market Analysis Outlook 2027 The Business Hours
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"The research study Head and Neck Cancer Market Global Trends, Growth, Size, status and Forecast 2027†is that the latest report added to the big market ...
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NASA Spaceline Current Awareness List #829 21 December 2018 (Space Life Science Research Results) - Space Ref
NASA Spaceline Current Awareness List #829 21 December 2018 (Space Life Science Research Results) Space Ref
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Posted: Friday, December 21, 2018. SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at ...
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NASA Spaceline Current Awareness List #829 21 December 2018 (Space Life Science Research Results) - Space Ref
NASA Spaceline Current Awareness List #829 21 December 2018 (Space Life Science Research Results) Space Ref
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Posted: Friday, December 21, 2018. SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website at ...
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Smile aesthetics as perceived by dental students: a cross-sectional study
Abstract
Background
An aesthetic smile has a number of components, and people generally equate a good dental appearance with success in many areas of life. The features that determine smile aesthetics could provide significant insights into post-treatment satisfaction and may predict a patient's objectives when undergoing treatment. The purpose of this study was to evaluate how smile characteristics are perceived by dental students.
Methods
The study was performed in 431 local and international dental students at the Lithuanian University of Health Sciences. The study data were collected using a three-part questionnaire. The first part of the questionnaire included sociodemographic items, i.e., student gender, age, nationality, and years of study; the second consisted of questions about facial aesthetic features; and the third elicited responses to photographs of 17 different smiles retrieved from the Lithuanian University of Health Sciences Clinic of Orthodontics database. The smile aesthetics were evaluated according to their dentolabial, dentogingival, dental, and dental arch characteristics using a 5-point numeric rating scale (1, best; 5, worst). The data were analysed using the Pearson's chi-square and Mann-Whitney U tests.
Results
The study included 336 local and 95 international dental students (132 men [30.6%], 299 women [69.4%]). Significantly more women than men focused on a person's teeth when communicating (41.5% vs.32.6%, p < 0.005). Women were more critical than men when evaluating gingival smile, the 'golden proportion', occlusal cant, and dental crowding. The most unfavourable smile characteristics were identified in the dental analysis category, with hypodontia ranked as the worst smile feature (mean numeric rating scale score 4.71).
Conclusion
Among dental students, the most distracting characteristics of a smile when determining its attractiveness were hypodontia, gingival smile, a reversed curvature of the occlusal plane, and dental crowding.
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Smile aesthetics as perceived by dental students: a cross-sectional study
Abstract
Background
An aesthetic smile has a number of components, and people generally equate a good dental appearance with success in many areas of life. The features that determine smile aesthetics could provide significant insights into post-treatment satisfaction and may predict a patient's objectives when undergoing treatment. The purpose of this study was to evaluate how smile characteristics are perceived by dental students.
Methods
The study was performed in 431 local and international dental students at the Lithuanian University of Health Sciences. The study data were collected using a three-part questionnaire. The first part of the questionnaire included sociodemographic items, i.e., student gender, age, nationality, and years of study; the second consisted of questions about facial aesthetic features; and the third elicited responses to photographs of 17 different smiles retrieved from the Lithuanian University of Health Sciences Clinic of Orthodontics database. The smile aesthetics were evaluated according to their dentolabial, dentogingival, dental, and dental arch characteristics using a 5-point numeric rating scale (1, best; 5, worst). The data were analysed using the Pearson's chi-square and Mann-Whitney U tests.
Results
The study included 336 local and 95 international dental students (132 men [30.6%], 299 women [69.4%]). Significantly more women than men focused on a person's teeth when communicating (41.5% vs.32.6%, p < 0.005). Women were more critical than men when evaluating gingival smile, the 'golden proportion', occlusal cant, and dental crowding. The most unfavourable smile characteristics were identified in the dental analysis category, with hypodontia ranked as the worst smile feature (mean numeric rating scale score 4.71).
Conclusion
Among dental students, the most distracting characteristics of a smile when determining its attractiveness were hypodontia, gingival smile, a reversed curvature of the occlusal plane, and dental crowding.
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Post-auricular lump: CT diagnosis
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Artificial intelligence-assisted interpretation of bone age radiographs improves accuracy and decreases variability
Abstract
Objective
Radiographic bone age assessment (BAA) is used in the evaluation of pediatric endocrine and metabolic disorders. We previously developed an automated artificial intelligence (AI) deep learning algorithm to perform BAA using convolutional neural networks. We compared the BAA performance of a cohort of pediatric radiologists with and without AI assistance.
Materials and methods
Six board-certified, subspecialty trained pediatric radiologists interpreted 280 age- and gender-matched bone age radiographs ranging from 5 to 18 years. Three of those radiologists then performed BAA with AI assistance. Bone age accuracy and root mean squared error (RMSE) were used as measures of accuracy. Intraclass correlation coefficient evaluated inter-rater variation.
Results
AI BAA accuracy was 68.2% overall and 98.6% within 1 year, and the mean six-reader cohort accuracy was 63.6 and 97.4% within 1 year. AI RMSE was 0.601 years, while mean single-reader RMSE was 0.661 years. Pooled RMSE decreased from 0.661 to 0.508 years, all individually decreasing with AI assistance. ICC without AI was 0.9914 and with AI was 0.9951.
Conclusions
AI improves radiologist's bone age assessment by increasing accuracy and decreasing variability and RMSE. The utilization of AI by radiologists improves performance compared to AI alone, a radiologist alone, or a pooled cohort of experts. This suggests that AI may optimally be utilized as an adjunct to radiologist interpretation of imaging studies to improve performance.
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The effects of granulocyte colony-stimulating factor on MR images of bone marrow
Abstract
Granulocyte colony-stimulating factor (G-CSF) analogs such as filgrastim/pegfilgrastim are increasingly used to enhance neutrophilic recovery after chemotherapy. It is widely known that, physiologically, pegfilgrastim stimulates marrow mitotic activity and induces marrow reconversion from fatty to cellular. However, there is limited literature discussing the effects of pegfilgrastim on musculoskeletal magnetic resonance imaging, with the consensus that marrow reconversion secondary to pegfilgrastim therapy is easily confounded with a malignant process, especially in patients with a history of cancer. We attempt to discuss the expected changes and MRI findings after pegfilgrastim therapy through a summary of current literature. Additionally, we provide images from our own practice to support the previously established findings. G-CSF-stimulated reconversion can appear as patchy expansions of baseline hematopoietic marrow, but can also appear to be diffusely homogeneous, adding to its ambiguity. We conclude that using a baseline MRI, clinical information, and assessing sequential MRI changes in conjunction with pegfilgrastim therapy may aid the differentiation between benign and pathological change. We expand our discussion to include the effects of novel technologies, such as whole-body MRI, chemical shift imaging, and contrast agents in helping the distinction.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2CtUctg
High-pressure injection injury of the hand: peculiar MRI features and treatment implications
Abstract
High-pressure injection injuries of the hand are rare, but potentially devastating injuries. The amount of tissue damage is dependent on the magnitude of the pressure generated by the device and the composition of the injected material. The standard of care is emergent surgical debridement of the injected material and devitalized tissue. Although, preoperative advanced imaging is not routinely pursued, MRI may be helpful in determining the anatomic distribution of the foreign material, and associated soft tissue or osseous injury. We present a case of a 28-year-old male with complications related to a high-pressure grease injection injury to his non-dominant hand. The MRI demonstrated peculiar imaging features of retained grease deposits and played an important role in surgical planning.
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Unusual proximal fragment migration of an os peroneum fracture with associated peroneus longus tendon injury—a tree often hides a forest
Abstract
We report the case of a 55-year-old male patient who presented to the emergency department after sustaining a right ankle trauma. Swelling and tenderness of the lateral aspect of the right ankle were present on physical examination without evidence of motor or sensory deficit. Ankle radiographs were performed and showed two bony fragments, the first located postero-inferiorly to the cuboid bone while the second was adjacent to the tip of the lateral malleolus. The diagnosis of an os peroneum fracture was made with high suspicion of an associated peroneus longus tendon rupture. Computed tomography (CT) and magnetic resonance imaging (MRI) of the right ankle confirmed the diagnosis of a subtotal retracted tendinous rupture. Successful surgical repair of the injured tendon was performed. This article illustrates the imaging findings of an os peroneum fracture with its associated tendinous injury and reviews the literature.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2CtRpAk
Detecting intertrochanteric hip fractures with orthopedist-level accuracy using a deep convolutional neural network
Abstract
Objective
To compare performances in diagnosing intertrochanteric hip fractures from proximal femoral radiographs between a convolutional neural network and orthopedic surgeons.
Materials and methods
In total, 1773 patients were enrolled in this study. Hip plain radiographs from these patients were cropped to display only proximal fractured and non-fractured femurs. Images showing pseudarthrosis after femoral neck fracture and those showing artificial objects were excluded. This yielded a total of 3346 hip images (1773 fractured and 1573 non-fractured hip images) that were used to compare performances between the convolutional neural network and five orthopedic surgeons.
Results
The convolutional neural network and orthopedic surgeons had accuracies of 95.5% (95% CI = 93.1–97.6) and 92.2% (95% CI = 89.2–94.9), sensitivities of 93.9% (95% CI = 90.1–97.1) and 88.3% (95% CI = 83.3–92.8), and specificities of 97.4% (95% CI = 94.5–99.4) and 96.8% (95% CI = 95.1–98.4), respectively.
Conclusions
The performance of the convolutional neural network exceeded that of orthopedic surgeons in detecting intertrochanteric hip fractures from proximal femoral radiographs under limited conditions. The convolutional neural network has a significant potential to be a useful tool for screening for fractures on plain radiographs, especially in the emergency room, where orthopedic surgeons are not readily available.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2CsFdQ5
Point vs. traditional method evaluation of hallux valgus: interreader reliability and intermethod performance using X-ray and MRI
Abstract
Background
The two most widely used measurements for diagnosing and assessing the severity of hallux valgus are the hallux valgus angle (HVA) and the intermetatarsal angle (IMA). Traditionally, these have been measured by using the midaxial lines approximating the axis of each bone. A new simpler point method has been recently suggested for measuring these angles by connecting points along the medial corners of each bone. Interreader reliability of these measurements on X-ray and MRI as well as intermethod and intermodality differences have not been assessed.
Methods
A series of 56 consecutive patients between 18 and 100 years old with no history of foot trauma or orthopedic hardware in their feet were included. All had AP and lateral X-rays and MRI performed on the same foot between April 27, 2015 and March 9, 2016. Two readers measured HVA and IMA using both the traditional midaxial and new point methods. ICC correlations were obtained.
Results
The interreader reliability for HVA was similar on point method (0.92) and traditional method (0.94). For the IMA, the ICC was 0.77 on point method versus 0.76 on traditional method. The intermodality agreement (between X-ray and MRI) was higher for HVA (ICC = 0.85, 0.88) as compared to IMA (0.58, 0.74), respectively on both methods. The mean difference between the methods was larger on traditional method = 5.5 for HVA and 2.5° for IMA.
Conclusions
HVA is more reliable than IMA on both methods and modalities and a significant difference exists between the magnitudes of values obtained using the two methods.
Level of Clinical Evidence: 3
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MRI findings for unilateral sternoclavicular arthritis: differentiation between infectious arthritis and spondyloarthritis
Abstract
Objectives
To analyze and identify magnetic resonance imaging (MRI) and clinical findings for the differentiation between infectious arthritis and spondyloarthritis in patients with unilateral sternoclavicular arthritis.
Materials and methods
We retrospectively collected and evaluated the magnetic resonance (MR) images of 21 patients diagnosed with unilateral sternoclavicular arthritis, including 12 with infection and nine with spondyloarthritis, between 2004 and 2017. Capsular distension, extracapsular fluid collection, periarticular muscle edema, the prevalence and distribution of bone marrow edema, and the prevalence and size of bone erosions were assessed on the MR images. Clinical data were also reviewed.
Results
Capsular distension was more prominent in patients with infectious arthritis than those with spondyloarthritis (p = 0.002); extracapsular fluid collection and periarticular muscle edema were also more common in infectious arthritis than spondyloarthritis (p < 0.001, respectively); moreover, bone erosions were larger in infectious arthritis than spondyloarthritis (p = 0.023). Other findings significantly associated with infectious arthritis included advanced age (p = 0.007), an elevated C-reactive protein (CRP) level (p = 0.001), and erythrocyte sedimentation rate (ESR) (p < 0.001). The prevalence and distribution of bone marrow edema and the prevalence of bone erosions on MRI, the white blood cell count, and sex showed no significant differences between the two groups.
Conclusions
Capsular distension, extracapsular fluid collection, periarticular muscle edema, and the size of bone erosions on MRI, as well as the age, CRP level, and ESR of patients, could be helpful for differentiating infectious arthritis from spondyloarthritis involving the sternoclavicular joint.
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Incorporating musculoskeletal ultrasound into your radiology practice: patients, patience, and why your department cannot do without it
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Progression of dialysis-related amyloidoma towards pathologic fracture
Abstract
Amyloidosis is the extracellular deposition of amyloid protein fibrils, and this condition may be hereditary or acquired. Patients undergoing long-term hemodialysis are particularly at risk for developing acquired amyloidosis. A rare form of amyloidosis is an amyloidoma or amyloid tumor, which occurs when amyloid focally deposits in a section of the musculoskeletal system, most commonly in the osteoarticular system. Here, we present a case of a hemodialysis-related amyloidoma of the left femoral neck in an 80-year-old woman with end-stage renal disease on hemodialysis for 8 years. The purpose of this report is to provide an account of the unique clinical, imaging, and histopathologic manifestation of a dialysis-related amyloidoma that progressively enlarges over a 2-year period. This report also highlights some prophylactic measures that may reduce the risk of developing an associated pathologic fracture.
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Can effusion-synovitis measured on ultrasound or MRI predict response to intra-articular steroid injection in hip osteoarthritis?
Abstract
Objectives
Intra-articular steroid injection (IASI) is an effective therapy for hip osteoarthritis (OA), but carries risks and provides significant pain relief to only two thirds of patients. We attempted to predict response to IASI in hip OA patients using baseline clinical, ultrasound, and MRI data.
Methods
Observational study of 97 subjects with symptomatic hip OA presenting for IASI. At baseline and 8 weeks we obtained hip MRI, grayscale and Doppler ultrasound, clinical range of motion (ROM), timed-up and go test (TUG) scores, and self-reported Western Ontario and McMaster Universities Osteoarthritis (WOMAC) pain, stiffness, and function scores. Bone-capsule distance (BCD) measurements of inflammation on hip ultrasound and MRI were measured at three locations: the proximal-most uncovered portion of the femoral head, the superficial-most (apex) portion of the femoral head, and the largest fluid pocket at the femoral neck.
Results
Ultrasound and MRI BCD correlated with each other significantly and strongly at the apex and neck. Power Doppler findings did not correlate significantly with any other imaging indices. Eight weeks post-injection, WOMAC pain, function, and stiffness scores significantly improved and TUG time improved nearly to the level of significance, but there were no significant changes in ultrasound, MRI, or Doppler indices. Baseline variables were not significantly different between responder and nonresponder WOMAC pain or TUG time cohorts.
Conclusion
Basic measures of inflammation on ultrasound and MRI are highly related to each other, but provide little insight into patient function and pain after IASI. Other mechanisms to explain improvement in patient status after IASI are likely at work.
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Post-auricular lump: CT diagnosis
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Preliminary results: use of multi-hole injection nails for intramedullary nailing with simultaneous bone cement injection in long-bone metastasis
Abstract
Objective
For symptomatic metastasis of the long bones, intramedullary nailing has been the most accepted fixation method. Intramedullary nailing has effective control of pain, perioperative bleeding, and local tumor progression by augmentation with bone cement around the nail. Here, we report the preliminary results of a new surgical implant that allows for simultaneous injection of bone cement while inserting a percutaneous, flexible intramedullary nail.
Materials and methods
We performed palliative surgeries for long-bone metastasis using a multi-hole injection nail (MIN) with multiple side holes in the distal one third. When the nail tip entered the metastatic cancer lesion, the bone cement injection was started, and continued until the nail was completely seated. Ten patients with advanced cancer underwent palliative surgery using the new implant with simultaneous bone cement injection for humeral (n = 4), femoral (n = 4), and tibial (n = 2) metastases.
Results
The mean operative time was 42 min (range, 36–52 min). The mean length of the injection nail was 23.0 cm (range, 18.0–33.0 cm), and the mean volume of cement was 28.0 ml (range, 14.0–40.0 ml). Marked pain palliation (p < 0.001) and functional recovery (p = 0.01) were verified. The mean Musculoskeletal Tumor Society (MSTS) functional score improved significantly from 12.5 at 6 weeks preoperatively, to 24.9 postoperatively. No acute postoperative complications, including cement embolism, occurred.
Conclusion
This minimally invasive surgical method with MIN could be useful for stabilization of long-bone metastases in patients with advanced cancer.
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Post-auricular lump: CT diagnosis
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Artificial intelligence-assisted interpretation of bone age radiographs improves accuracy and decreases variability
Abstract
Objective
Radiographic bone age assessment (BAA) is used in the evaluation of pediatric endocrine and metabolic disorders. We previously developed an automated artificial intelligence (AI) deep learning algorithm to perform BAA using convolutional neural networks. We compared the BAA performance of a cohort of pediatric radiologists with and without AI assistance.
Materials and methods
Six board-certified, subspecialty trained pediatric radiologists interpreted 280 age- and gender-matched bone age radiographs ranging from 5 to 18 years. Three of those radiologists then performed BAA with AI assistance. Bone age accuracy and root mean squared error (RMSE) were used as measures of accuracy. Intraclass correlation coefficient evaluated inter-rater variation.
Results
AI BAA accuracy was 68.2% overall and 98.6% within 1 year, and the mean six-reader cohort accuracy was 63.6 and 97.4% within 1 year. AI RMSE was 0.601 years, while mean single-reader RMSE was 0.661 years. Pooled RMSE decreased from 0.661 to 0.508 years, all individually decreasing with AI assistance. ICC without AI was 0.9914 and with AI was 0.9951.
Conclusions
AI improves radiologist's bone age assessment by increasing accuracy and decreasing variability and RMSE. The utilization of AI by radiologists improves performance compared to AI alone, a radiologist alone, or a pooled cohort of experts. This suggests that AI may optimally be utilized as an adjunct to radiologist interpretation of imaging studies to improve performance.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2T8y90J
The effects of granulocyte colony-stimulating factor on MR images of bone marrow
Abstract
Granulocyte colony-stimulating factor (G-CSF) analogs such as filgrastim/pegfilgrastim are increasingly used to enhance neutrophilic recovery after chemotherapy. It is widely known that, physiologically, pegfilgrastim stimulates marrow mitotic activity and induces marrow reconversion from fatty to cellular. However, there is limited literature discussing the effects of pegfilgrastim on musculoskeletal magnetic resonance imaging, with the consensus that marrow reconversion secondary to pegfilgrastim therapy is easily confounded with a malignant process, especially in patients with a history of cancer. We attempt to discuss the expected changes and MRI findings after pegfilgrastim therapy through a summary of current literature. Additionally, we provide images from our own practice to support the previously established findings. G-CSF-stimulated reconversion can appear as patchy expansions of baseline hematopoietic marrow, but can also appear to be diffusely homogeneous, adding to its ambiguity. We conclude that using a baseline MRI, clinical information, and assessing sequential MRI changes in conjunction with pegfilgrastim therapy may aid the differentiation between benign and pathological change. We expand our discussion to include the effects of novel technologies, such as whole-body MRI, chemical shift imaging, and contrast agents in helping the distinction.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2CtUctg
Unusual proximal fragment migration of an os peroneum fracture with associated peroneus longus tendon injury—a tree often hides a forest
Abstract
We report the case of a 55-year-old male patient who presented to the emergency department after sustaining a right ankle trauma. Swelling and tenderness of the lateral aspect of the right ankle were present on physical examination without evidence of motor or sensory deficit. Ankle radiographs were performed and showed two bony fragments, the first located postero-inferiorly to the cuboid bone while the second was adjacent to the tip of the lateral malleolus. The diagnosis of an os peroneum fracture was made with high suspicion of an associated peroneus longus tendon rupture. Computed tomography (CT) and magnetic resonance imaging (MRI) of the right ankle confirmed the diagnosis of a subtotal retracted tendinous rupture. Successful surgical repair of the injured tendon was performed. This article illustrates the imaging findings of an os peroneum fracture with its associated tendinous injury and reviews the literature.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2CtRpAk
Differentiation between malignant and benign musculoskeletal tumors using diffusion kurtosis imaging
Abstract
Objective
The purpose of this study was to evaluate differences in parameters of diffusion kurtosis imaging (DKI) and minimum apparent diffusion coefficient (ADCmin) between benign and malignant musculoskeletal tumors.
Materials and methods
In this prospective study, 43 patients were scanned using a DKI protocol on a 3-T MR scanner. Eligibility criteria were: non-fatty, non-cystic soft tissue or osteolytic tumors; > 2 cm; location in the retroperitoneum, pelvis, leg, or neck; and no prior treatment. They were clinically or histologically diagnosed as benign (n = 27) or malignant (n = 16). In the DKI protocol, diffusion-weighted imaging was performed using four b values (0-2000 s/mm2) and 21 diffusion directions. Mean kurtosis (MK) values were calculated on the MR console. A recently developed software application enabling reliable calculation was used for DKI analysis.
Results
MK showed a strong correction with ADCmin (Spearman's rs = 0.95). Both MK and ADCmin values differed between benign and malignant tumors (p < 0.01). For benign and malignant tumors, the mean MK values (± SD) were 0.49 ± 0.17 and 1.14 ± 0.30, respectively, and ADCmin values were 1.54 ± 0.47 and 0.49 ± 0.17 × 10−3 mm2/s, respectively. At cutoffs of MK = 0.81 and ADCmin = 0.77 × 10−3 mm2/s, the specificity and sensitivity for diagnosis of malignant tumors were 96.3 and 93.8% for MK and 96.3 and 93.8% for ADCmin, respectively. The areas under the curve were 0.97 and 0.99 for MK and ADCmin, respectively (p = 0.31).
Conclusions
MK and ADCmin showed high diagnostic accuracy and strong correlation, reflecting the accuracy of MK. However, no clear added value of DKI could be demonstrated in differentiating musculoskeletal tumors.
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Detecting intertrochanteric hip fractures with orthopedist-level accuracy using a deep convolutional neural network
Abstract
Objective
To compare performances in diagnosing intertrochanteric hip fractures from proximal femoral radiographs between a convolutional neural network and orthopedic surgeons.
Materials and methods
In total, 1773 patients were enrolled in this study. Hip plain radiographs from these patients were cropped to display only proximal fractured and non-fractured femurs. Images showing pseudarthrosis after femoral neck fracture and those showing artificial objects were excluded. This yielded a total of 3346 hip images (1773 fractured and 1573 non-fractured hip images) that were used to compare performances between the convolutional neural network and five orthopedic surgeons.
Results
The convolutional neural network and orthopedic surgeons had accuracies of 95.5% (95% CI = 93.1–97.6) and 92.2% (95% CI = 89.2–94.9), sensitivities of 93.9% (95% CI = 90.1–97.1) and 88.3% (95% CI = 83.3–92.8), and specificities of 97.4% (95% CI = 94.5–99.4) and 96.8% (95% CI = 95.1–98.4), respectively.
Conclusions
The performance of the convolutional neural network exceeded that of orthopedic surgeons in detecting intertrochanteric hip fractures from proximal femoral radiographs under limited conditions. The convolutional neural network has a significant potential to be a useful tool for screening for fractures on plain radiographs, especially in the emergency room, where orthopedic surgeons are not readily available.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2CsFdQ5
Point vs. traditional method evaluation of hallux valgus: interreader reliability and intermethod performance using X-ray and MRI
Abstract
Background
The two most widely used measurements for diagnosing and assessing the severity of hallux valgus are the hallux valgus angle (HVA) and the intermetatarsal angle (IMA). Traditionally, these have been measured by using the midaxial lines approximating the axis of each bone. A new simpler point method has been recently suggested for measuring these angles by connecting points along the medial corners of each bone. Interreader reliability of these measurements on X-ray and MRI as well as intermethod and intermodality differences have not been assessed.
Methods
A series of 56 consecutive patients between 18 and 100 years old with no history of foot trauma or orthopedic hardware in their feet were included. All had AP and lateral X-rays and MRI performed on the same foot between April 27, 2015 and March 9, 2016. Two readers measured HVA and IMA using both the traditional midaxial and new point methods. ICC correlations were obtained.
Results
The interreader reliability for HVA was similar on point method (0.92) and traditional method (0.94). For the IMA, the ICC was 0.77 on point method versus 0.76 on traditional method. The intermodality agreement (between X-ray and MRI) was higher for HVA (ICC = 0.85, 0.88) as compared to IMA (0.58, 0.74), respectively on both methods. The mean difference between the methods was larger on traditional method = 5.5 for HVA and 2.5° for IMA.
Conclusions
HVA is more reliable than IMA on both methods and modalities and a significant difference exists between the magnitudes of values obtained using the two methods.
Level of Clinical Evidence: 3
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2T2xgGQ
MRI findings for unilateral sternoclavicular arthritis: differentiation between infectious arthritis and spondyloarthritis
Abstract
Objectives
To analyze and identify magnetic resonance imaging (MRI) and clinical findings for the differentiation between infectious arthritis and spondyloarthritis in patients with unilateral sternoclavicular arthritis.
Materials and methods
We retrospectively collected and evaluated the magnetic resonance (MR) images of 21 patients diagnosed with unilateral sternoclavicular arthritis, including 12 with infection and nine with spondyloarthritis, between 2004 and 2017. Capsular distension, extracapsular fluid collection, periarticular muscle edema, the prevalence and distribution of bone marrow edema, and the prevalence and size of bone erosions were assessed on the MR images. Clinical data were also reviewed.
Results
Capsular distension was more prominent in patients with infectious arthritis than those with spondyloarthritis (p = 0.002); extracapsular fluid collection and periarticular muscle edema were also more common in infectious arthritis than spondyloarthritis (p < 0.001, respectively); moreover, bone erosions were larger in infectious arthritis than spondyloarthritis (p = 0.023). Other findings significantly associated with infectious arthritis included advanced age (p = 0.007), an elevated C-reactive protein (CRP) level (p = 0.001), and erythrocyte sedimentation rate (ESR) (p < 0.001). The prevalence and distribution of bone marrow edema and the prevalence of bone erosions on MRI, the white blood cell count, and sex showed no significant differences between the two groups.
Conclusions
Capsular distension, extracapsular fluid collection, periarticular muscle edema, and the size of bone erosions on MRI, as well as the age, CRP level, and ESR of patients, could be helpful for differentiating infectious arthritis from spondyloarthritis involving the sternoclavicular joint.
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Incorporating musculoskeletal ultrasound into your radiology practice: patients, patience, and why your department cannot do without it
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Progression of dialysis-related amyloidoma towards pathologic fracture
Abstract
Amyloidosis is the extracellular deposition of amyloid protein fibrils, and this condition may be hereditary or acquired. Patients undergoing long-term hemodialysis are particularly at risk for developing acquired amyloidosis. A rare form of amyloidosis is an amyloidoma or amyloid tumor, which occurs when amyloid focally deposits in a section of the musculoskeletal system, most commonly in the osteoarticular system. Here, we present a case of a hemodialysis-related amyloidoma of the left femoral neck in an 80-year-old woman with end-stage renal disease on hemodialysis for 8 years. The purpose of this report is to provide an account of the unique clinical, imaging, and histopathologic manifestation of a dialysis-related amyloidoma that progressively enlarges over a 2-year period. This report also highlights some prophylactic measures that may reduce the risk of developing an associated pathologic fracture.
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Can effusion-synovitis measured on ultrasound or MRI predict response to intra-articular steroid injection in hip osteoarthritis?
Abstract
Objectives
Intra-articular steroid injection (IASI) is an effective therapy for hip osteoarthritis (OA), but carries risks and provides significant pain relief to only two thirds of patients. We attempted to predict response to IASI in hip OA patients using baseline clinical, ultrasound, and MRI data.
Methods
Observational study of 97 subjects with symptomatic hip OA presenting for IASI. At baseline and 8 weeks we obtained hip MRI, grayscale and Doppler ultrasound, clinical range of motion (ROM), timed-up and go test (TUG) scores, and self-reported Western Ontario and McMaster Universities Osteoarthritis (WOMAC) pain, stiffness, and function scores. Bone-capsule distance (BCD) measurements of inflammation on hip ultrasound and MRI were measured at three locations: the proximal-most uncovered portion of the femoral head, the superficial-most (apex) portion of the femoral head, and the largest fluid pocket at the femoral neck.
Results
Ultrasound and MRI BCD correlated with each other significantly and strongly at the apex and neck. Power Doppler findings did not correlate significantly with any other imaging indices. Eight weeks post-injection, WOMAC pain, function, and stiffness scores significantly improved and TUG time improved nearly to the level of significance, but there were no significant changes in ultrasound, MRI, or Doppler indices. Baseline variables were not significantly different between responder and nonresponder WOMAC pain or TUG time cohorts.
Conclusion
Basic measures of inflammation on ultrasound and MRI are highly related to each other, but provide little insight into patient function and pain after IASI. Other mechanisms to explain improvement in patient status after IASI are likely at work.
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This big Warriors backer now is shooting for biotech - San Francisco Business Times
This big Warriors backer now is shooting for biotech San Francisco Business Times
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Hiroshi "Mickey" Mikitani, whose Rakuten conglomerate has its name on Golden State Warriors jerseys, is taking a bigger stake in a biotech company called ...
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Cisplatin Superior to Cetuximab for HPV+ Oropharyngeal Cancer - Infectious Disease Advisor
Cisplatin Superior to Cetuximab for HPV+ Oropharyngeal Cancer Infectious Disease Advisor
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For treatment of HPV positive low-risk oropharyngeal cancer, cetuximab shows no benefit compared with the standard cisplatin regimen in terms of reduced ...
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This big Warriors backer now is shooting for biotech - San Francisco Business Times
This big Warriors backer now is shooting for biotech San Francisco Business Times
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Hiroshi "Mickey" Mikitani, whose Rakuten conglomerate has its name on Golden State Warriors jerseys, is taking a bigger stake in a biotech company called ...
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Cisplatin Superior to Cetuximab for HPV+ Oropharyngeal Cancer - Infectious Disease Advisor
Cisplatin Superior to Cetuximab for HPV+ Oropharyngeal Cancer Infectious Disease Advisor
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For treatment of HPV positive low-risk oropharyngeal cancer, cetuximab shows no benefit compared with the standard cisplatin regimen in terms of reduced ...
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Diagnosis of thyroid cancer using deep convolutional neural network models applied to sonographic images: a retrospective, multicohort, diagnostic study - The Lancet
Diagnosis of thyroid cancer using deep convolutional neural network models applied to sonographic images: a retrospective, multicohort, diagnostic study The Lancet
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The incidence of thyroid cancer is rising steadily because of overdiagnosis and overtreatment conferred by widespread use of sensitive imaging techniques for ...
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Diagnosis of thyroid cancer using deep convolutional neural network models applied to sonographic images: a retrospective, multicohort, diagnostic study - The Lancet
Diagnosis of thyroid cancer using deep convolutional neural network models applied to sonographic images: a retrospective, multicohort, diagnostic study The Lancet
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The incidence of thyroid cancer is rising steadily because of overdiagnosis and overtreatment conferred by widespread use of sensitive imaging techniques for ...
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MRI assessment of aortic flow in patients with pulmonary arterial hypertension in response to exercise
Abstract
Background
While primarily a right heart disease, pulmonary arterial hypertension (PAH) can impact left heart function and aortic flow through a shifted interventricular septum from right ventricular pressure overload and reduced left ventricular preload, among other mechanisms. In this study, we used phase contrast (PC) MRI and a modest exercise challenge to examine the effects of PAH on systemic circulation. While exercise challenges are typically performed with ultrasound in the clinic, MRI exercise studies allow for more reproducible image alignment, more accurate flow quantification, and improved tissue contrast.
Methods
Six PAH patients and fifteen healthy controls (8 older age-matched, 7 younger) exercised in the magnet bore with an MRI-compatible exercise device that allowed for scanning immediately following cessation of exercise. PC scans were performed in the ascending aorta during a breath hold immediately after modest exercise to non-invasively measure stroke volume (SV), cardiac output (CO), aortic peak systolic flow (PSF), and aortic wall stiffness via relative area change (RAC).
Results
Images following exercise showed mild blurring, but were high enough quality to allow for segmentation of the aorta. While SV was approximately 30% lower in PAH patients (SVPAH,rest = 67 ± 16 mL; SVPAH,stress = 90 ± 42 mL) than age-matched controls (SV,older,rest = 93 ± 16 mL; SVolder,stress = 133 ± 40 mL) at both rest and following exercise, CO was similar for both groups following exercise (COPAH,stress = 10.8 ± 5.7 L/min; COolder,stress = 11.8 ± 5.0 L/min). This was achieved through a compensatory increase in heart rate in the PAH subjects (74% increase as compared to 29% in age-matched controls). The PAH subjects also demonstrated reduced aortic peak systolic flow relative to the healthy controls (PSFPAH,rest = 309 ± 52 mL/s; PSFolder,rest = 416 ± 114 mL/s; PSFPAH,stress = 388 ± 113 mL/s; PSFolder,stress = 462 ± 176 mL/s). PAH patients and older controls demonstrated stiffer aortic walls when compared to younger controls (RACPAH,rest = 0.15 ± 0.05; RAColder,rest = 0.17 ± 0.05; RACyoung,rest = 0.28 ± 0.08).
Conclusions
PC MRI following a modest exercise challenge was capable of detecting differences in left heart dynamics likely induced from PAH. These results demonstrated that PAH can have a significant influence on systemic flow, even when the patient has no prior left heart disease. Image quantification following exercise could likely be improved in future studies through the implementation of free-breathing or real-time MRI acquisitions.
Trial registration
Retrospectively registered on 02/26/2018 (TRN:NCT03523910).
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MRI assessment of aortic flow in patients with pulmonary arterial hypertension in response to exercise
Abstract
Background
While primarily a right heart disease, pulmonary arterial hypertension (PAH) can impact left heart function and aortic flow through a shifted interventricular septum from right ventricular pressure overload and reduced left ventricular preload, among other mechanisms. In this study, we used phase contrast (PC) MRI and a modest exercise challenge to examine the effects of PAH on systemic circulation. While exercise challenges are typically performed with ultrasound in the clinic, MRI exercise studies allow for more reproducible image alignment, more accurate flow quantification, and improved tissue contrast.
Methods
Six PAH patients and fifteen healthy controls (8 older age-matched, 7 younger) exercised in the magnet bore with an MRI-compatible exercise device that allowed for scanning immediately following cessation of exercise. PC scans were performed in the ascending aorta during a breath hold immediately after modest exercise to non-invasively measure stroke volume (SV), cardiac output (CO), aortic peak systolic flow (PSF), and aortic wall stiffness via relative area change (RAC).
Results
Images following exercise showed mild blurring, but were high enough quality to allow for segmentation of the aorta. While SV was approximately 30% lower in PAH patients (SVPAH,rest = 67 ± 16 mL; SVPAH,stress = 90 ± 42 mL) than age-matched controls (SV,older,rest = 93 ± 16 mL; SVolder,stress = 133 ± 40 mL) at both rest and following exercise, CO was similar for both groups following exercise (COPAH,stress = 10.8 ± 5.7 L/min; COolder,stress = 11.8 ± 5.0 L/min). This was achieved through a compensatory increase in heart rate in the PAH subjects (74% increase as compared to 29% in age-matched controls). The PAH subjects also demonstrated reduced aortic peak systolic flow relative to the healthy controls (PSFPAH,rest = 309 ± 52 mL/s; PSFolder,rest = 416 ± 114 mL/s; PSFPAH,stress = 388 ± 113 mL/s; PSFolder,stress = 462 ± 176 mL/s). PAH patients and older controls demonstrated stiffer aortic walls when compared to younger controls (RACPAH,rest = 0.15 ± 0.05; RAColder,rest = 0.17 ± 0.05; RACyoung,rest = 0.28 ± 0.08).
Conclusions
PC MRI following a modest exercise challenge was capable of detecting differences in left heart dynamics likely induced from PAH. These results demonstrated that PAH can have a significant influence on systemic flow, even when the patient has no prior left heart disease. Image quantification following exercise could likely be improved in future studies through the implementation of free-breathing or real-time MRI acquisitions.
Trial registration
Retrospectively registered on 02/26/2018 (TRN:NCT03523910).
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Impact of organ prioritization for immunological sensitization and waiting times for heart transplantation
Sensitization refers to the presence of antibodies to human leukocyte antigens (HLA). The percentage calculated panel reactive antibody (CPRA) is a measure of sensitization with higher CPRA associated with increased unacceptable donor HLA, a smaller pool of potential donors, and longer waiting times for an HLA compatible donor.1 Sensitization rates in heart transplant candidates have increased with 1 in 5 patients having a CPRA>10% reported in the International Society of Heart and Lung Transplantation (ISHLT) registry. (Source: The Journal of Heart and Lung Transplantation)
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Fukushima Screening Program Sheds Light on Pediatric Thyroid Cancer - Cancer Network
Fukushima Screening Program Sheds Light on Pediatric Thyroid Cancer Cancer Network
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The thyroid screening program put in place after the 2011 Fukushima Daiichi nuclear power station accident resulted in the diagnosis of a number of pediatric ...
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Fukushima Screening Program Sheds Light on Pediatric Thyroid Cancer - Cancer Network
Fukushima Screening Program Sheds Light on Pediatric Thyroid Cancer Cancer Network
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The thyroid screening program put in place after the 2011 Fukushima Daiichi nuclear power station accident resulted in the diagnosis of a number of pediatric ...
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Fukushima Screening Program Sheds Light on Pediatric Thyroid Cancer - Cancer Network
Fukushima Screening Program Sheds Light on Pediatric Thyroid Cancer Cancer Network
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The thyroid screening program put in place after the 2011 Fukushima Daiichi nuclear power station accident resulted in the diagnosis of a number of pediatric ...
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Merck KGaA, Darmstadt, Germany, and Pfizer Provide Update on JAVELIN Ovarian 100 Trial of Avelumab in Previously Untreated Advanced Ovarian Cancer - GuruFocus.com
PR Newswire. DARMSTADT, Germany, and NEW YORK, December 21, 2018. DARMSTADT, Germany, and NEW YORK, December 21, 2018 /PRNewswire/ --.
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Anaplastic Thyroid Cancer Drug Market Competition, Status and Forecast, Market Size by Players, Regions, Type, Application by 2025 - DigiTribune
Anaplastic Thyroid Cancer Drug Market Report covers the manufacturers data, including: shipment, price, revenue, gross profit, interview record, business ...
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Fukushima Screening Program Sheds Light on Pediatric Thyroid Cancer - Cancer Network
Fukushima Screening Program Sheds Light on Pediatric Thyroid Cancer Cancer Network
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The thyroid screening program put in place after the 2011 Fukushima Daiichi nuclear power station accident resulted in the diagnosis of a number of pediatric ...
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Merck KGaA, Darmstadt, Germany, and Pfizer Provide Update on JAVELIN Ovarian 100 Trial of Avelumab in Previously Untreated Advanced Ovarian Cancer - GuruFocus.com
PR Newswire. DARMSTADT, Germany, and NEW YORK, December 21, 2018. DARMSTADT, Germany, and NEW YORK, December 21, 2018 /PRNewswire/ --.
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Anaplastic Thyroid Cancer Drug Market Competition, Status and Forecast, Market Size by Players, Regions, Type, Application by 2025 - DigiTribune
Anaplastic Thyroid Cancer Drug Market Report covers the manufacturers data, including: shipment, price, revenue, gross profit, interview record, business ...
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Clinical pharmacology in HIV cure research - what impact have we seen?
Authors: Giacomelli A, de Rose S, Rusconi S Abstract Introduction Combined antiretroviral therapy (cART) has transformed an inexorably fatal disease into a chronic pathology, shifting the focus of research from the control of viral replication to the possibility of HIV cure. Areas covered The present review assesses the principal pharmacological strategies that have been tested for an HIV cure starting from the in vitro proof of concept and the potential rationale of their in vivo applicability. We evaluated the possible pharmacological procedures employed during the early-stage HIV infection and the possibility of cART-free remission. We then analysed the shock and kill approach from the single compounds in vitro mechanism of action, to the in vivo application of single or combine...
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
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Clinical pharmacology in HIV cure research - what impact have we seen?
Authors: Giacomelli A, de Rose S, Rusconi S Abstract Introduction Combined antiretroviral therapy (cART) has transformed an inexorably fatal disease into a chronic pathology, shifting the focus of research from the control of viral replication to the possibility of HIV cure. Areas covered The present review assesses the principal pharmacological strategies that have been tested for an HIV cure starting from the in vitro proof of concept and the potential rationale of their in vivo applicability. We evaluated the possible pharmacological procedures employed during the early-stage HIV infection and the possibility of cART-free remission. We then analysed the shock and kill approach from the single compounds in vitro mechanism of action, to the in vivo application of single or combine...
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Value-Based Costs of Undesignated School Stock Epinephrine Policies for Peanut Anaphylaxis
This analysis uses Markov simulations of the Chicago Public Schools system to define value-based strategies and cost-effectiveness of undesignated school stock epinephrine programs based on analysis of children with peanut allergies. (Source: JAMA Pediatrics)
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Notes from the Field: Infections After Receipt of Bacterially Contaminated Umbilical Cord Blood-Derived Stem Cell Products for Other Than Hematopoietic or Immunologic Reconstitution - United States, 2018.
Authors: Perkins KM, Spoto S, Rankin DA, Dotson NQ, Malarkey M, Mendoza M, McNeill L, Gable P, Powell KM PMID: 30571672 [PubMed - in process] (Source: MMWR Morb Mortal Wkl...)
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Value-Based Costs of Undesignated School Stock Epinephrine Policies for Peanut Anaphylaxis
This analysis uses Markov simulations of the Chicago Public Schools system to define value-based strategies and cost-effectiveness of undesignated school stock epinephrine programs based on analysis of children with peanut allergies. (Source: JAMA Pediatrics)
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Notes from the Field: Infections After Receipt of Bacterially Contaminated Umbilical Cord Blood-Derived Stem Cell Products for Other Than Hematopoietic or Immunologic Reconstitution - United States, 2018.
Authors: Perkins KM, Spoto S, Rankin DA, Dotson NQ, Malarkey M, Mendoza M, McNeill L, Gable P, Powell KM PMID: 30571672 [PubMed - in process] (Source: MMWR Morb Mortal Wkl...)
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Are night sweats a sign of low testosterone? - Medical News Today
Are night sweats a sign of low testosterone? Medical News Today
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Sweating at night may be a sign of low testosterone in males or menopause in females. Treatment often involves supplementing the hormone to correct an ...
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”F cancer, I’m going skiing” - SNEWS
Beloved PR guy, John DiCuollo of Backbone Media, is fighting Hodgkins Lymphoma the only way he knows how: by staying positive and carving turns.
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Are night sweats a sign of low testosterone? - Medical News Today
Are night sweats a sign of low testosterone? Medical News Today
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Sweating at night may be a sign of low testosterone in males or menopause in females. Treatment often involves supplementing the hormone to correct an ...
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”F cancer, I’m going skiing” - SNEWS
Beloved PR guy, John DiCuollo of Backbone Media, is fighting Hodgkins Lymphoma the only way he knows how: by staying positive and carving turns.
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IMvoke010 Trial to Assess Adjuvant Atezolizumab in SCCHN - OncLive
An ongoing randomized phase III study will compare the safety and efficacy of atezolizumab with placebo as adjuvant therapy after definitive local therapy in ...
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IMvoke010 Trial to Assess Adjuvant Atezolizumab in SCCHN - OncLive
An ongoing randomized phase III study will compare the safety and efficacy of atezolizumab with placebo as adjuvant therapy after definitive local therapy in ...
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Sorafenib Doubles PFS at 2 Years in Patients With Desmoid Tumors for 'New Standard of Care' - MedPage Today
Sorafenib Doubles PFS at 2 Years in Patients With Desmoid Tumors for 'New Standard of Care' MedPage Today
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CME Author: Vicki Brower. Study Authors: Mrinal M. Gounder, Michelle R. Mahoney, et al. Target Audience and Goal Statement: Oncologists, pediatric ...
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Sorafenib Doubles PFS at 2 Years in Patients With Desmoid Tumors for 'New Standard of Care' - MedPage Today
Sorafenib Doubles PFS at 2 Years in Patients With Desmoid Tumors for 'New Standard of Care' MedPage Today
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CME Author: Vicki Brower. Study Authors: Mrinal M. Gounder, Michelle R. Mahoney, et al. Target Audience and Goal Statement: Oncologists, pediatric ...
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The Prosody of Rhetorical and Information-Seeking Questions in German.
Authors: Braun B, Dehé N, Neitsch J, Wochner D, Zahner K Abstract This paper reports on the prosody of rhetorical questions (RQs) and information-seeking questions (ISQs) in German for two question types-polar questions and constituent questions (henceforth " wh-questions"). The results are as follows: Phonologically, polar RQs were mainly realized with H-% (high plateau), while polar ISQs mostly ended in H-^H% (high-rise). Wh-RQs almost exclusively terminated in a low edge tone, whereas wh-ISQs allowed for more tonal variation (L-%, L-H%, H-^H%). Irrespective of question type, RQs were mainly produced with L*+H accents. Phonetically, RQs were more often realized with breathy voice quality than ISQs, in particular in the beginning of the interrogative. Furthermore, they were produ...
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The Prosody of Rhetorical and Information-Seeking Questions in German.
Authors: Braun B, Dehé N, Neitsch J, Wochner D, Zahner K Abstract This paper reports on the prosody of rhetorical questions (RQs) and information-seeking questions (ISQs) in German for two question types-polar questions and constituent questions (henceforth " wh-questions"). The results are as follows: Phonologically, polar RQs were mainly realized with H-% (high plateau), while polar ISQs mostly ended in H-^H% (high-rise). Wh-RQs almost exclusively terminated in a low edge tone, whereas wh-ISQs allowed for more tonal variation (L-%, L-H%, H-^H%). Irrespective of question type, RQs were mainly produced with L*+H accents. Phonetically, RQs were more often realized with breathy voice quality than ISQs, in particular in the beginning of the interrogative. Furthermore, they were produ...
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What Can You Do For Your Loved Ones When You’re Dying Of Cancer? - Forbes
Data always has a face. Here is the advice that people who have struggled with cancer had for others at this year's Forbes Healthcare Summit.
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Mentally ill and homeless, he rolls into traffic to die but goes to jail instead - Lexington Herald-Leader
Mentally ill and homeless, he rolls into traffic to die but goes to jail instead Lexington Herald-Leader
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James Edmonds, a homeless and severely mentally ill man, has rolled his wheelchair into downtown Lexington traffic for years, trying to die and often going to ...
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