Clinical pharmacology in HIV cure research - what impact have we seen?

Authors: Giacomelli A, de Rose S, Rusconi S Abstract Introduction Combined antiretroviral therapy (cART) has transformed an inexorably fatal disease into a chronic pathology, shifting the focus of research from the control of viral replication to the possibility of HIV cure. Areas covered The present review assesses the principal pharmacological strategies that have been tested for an HIV cure starting from the in vitro proof of concept and the potential rationale of their in vivo applicability. We evaluated the possible pharmacological procedures employed during the early-stage HIV infection and the possibility of cART-free remission. We then analysed the shock and kill approach from the single compounds in vitro mechanism of action, to the in vivo application of single or combine...

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2V1XCuq