No abstract available
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2yCukZF
Πέμπτη 25 Οκτωβρίου 2018
The Timing of Chemoprophylaxis in Autologous Microsurgical Breast Reconstruction
Background: Patients undergoing autologous breast reconstruction are at high risk of perioperative venous thromboembolic events. The efficacy of chemoprophylaxis in decreasing venous thromboembolic events is well established, but the timing of chemoprophylaxis remains controversial. The authors compare the incidence of bleeding following preoperative versus postoperative initiation of chemoprophylaxis in microvascular breast reconstruction. Methods: A retrospective chart review was performed from August of 2010 to July of 2016. Initiation of chemoprophylaxis changed from postoperative to preoperative in 2013, dividing subjects into two groups. Patient demographics, comorbidities, and complications were reviewed. Results: A total of 196 patients (311 flaps) were included in the study. A total of 105 patients (166 flaps) received preoperative enoxaparin (40 mg) and 91 patients (145 flaps) received postoperative chemoprophylaxis. A total of five patients required hematoma evacuation (2.6 percent). Of these, one hematoma (1 percent) occurred in the preoperative chemoprophylaxis group. Seven patients received blood transfusions: three in the preoperative group and four in the postoperative group (2.9 percent versus 4.4 percent; p = 0.419). There was a total of one flap failure, and there were no documented venous thromboembolic events in any of the groups. Conclusions: This study demonstrates that preoperative chemoprophylaxis can be used safely in patients undergoing microvascular breast reconstruction. The higher rate of bleeding in the postoperative group may be related to the onset of action of enoxaparin of 4 to 6 hours, which allows for intraoperative hemostasis in the preoperative group and possibly potentiating postoperative oozing when administered postoperatively. CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, III.from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2O703qE
Hybrid Prepectoral Breast Reconstruction: A Surgical Approach that Combines the Benefits of Autologous and Implant-Based Reconstruction
Background: The advantages of hybrid breast reconstruction (i.e., the combination of free tissue transfer with simultaneous implant placement) are well known. In an attempt to further minimize morbidity and simplify the procedure, the authors have modified their approach in that a prepectoral approach is now routinely chosen. Methods: A retrospective analysis of patients who underwent immediate microsurgical breast reconstruction with simultaneous prepectoral implant placement was performed. Clinical outcomes and postoperative complications were examined. Results: A total of 23 patients with a mean age of 46.6 years (range, 26 to 72 years) and mean body mass index of 25.8 kg/m2 (range, 21.4 to 32.1 kg/m2) underwent reconstruction with 46 free flaps with simultaneous prepectoral silicone gel implant placement. The most common implant volume was 210 cc (range, 150 to 255 cc). Postoperative complications included hematoma [n = 1 (4.3 percent)], mastectomy skin flap necrosis [n = 5 (21.7 percent)], fat necrosis [n = 3 (13 percent)], and delayed wound healing at the flap donor site [n = 4 (17.4 percent)]. No case of implant malposition, implant infection, flap loss, or "red breast" syndrome was encountered during a mean follow-up of 8.4 months (range, 2 to 17 months). Conclusions: Prepectoral hybrid breast reconstruction is a safe procedure that combines the benefits of autologous and implant-based reconstruction. Although the transfer of well-vascularized soft tissue allows reconstruction of natural breast ptosis, the addition of an implant provides the desired projection, but without being associated with complications such as rippling or animation deformity. CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, IV.from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2yB6ei9
Reply: Targeting Reflux-Free Veins with a Vein Visualizer to Identify the Ideal Recipient Vein Preoperatively for Optimal Lymphaticovenous Anastomosis in Treating Lymphedema
Sifting through the Ashes to Find the Meaning of Resilience
No abstract availablefrom #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2yCjIKg
Perioperative Ketorolac Use and Postoperative Hematoma Formation in Reduction Mammaplasty: A Single-Surgeon Experience of 500 Consecutive Cases
Background: In light of the escalating opioid crisis, surgeons are increasingly focused on minimizing opioid use. Ketorolac has well-documented opioid-sparing effects in the postoperative period; however, its use is limited because of concerns of postoperative bleeding and hematoma formation. This study explores the relationship between hematoma formation and administration of perioperative ketorolac in adolescent female patients and young adult women undergoing reduction mammaplasty. It also aims to determine the effect of perioperative ketorolac administration on the requirement for opioid analgesia. Methods: The authors reviewed the medical records of 500 consecutive female patients who underwent reduction mammaplasty for bilateral macromastia from 2007 to 2017. The authors collected data pertaining to perioperative analgesia use and postoperative hematoma formation. Results: Five-hundred patients were included in analyses. The average age of the patients was 18.1 ± 2.2 years. Three hundred eighty-nine patients (77.8 percent) received intravenous ketorolac during the perioperative period. Seven patients (1.4 percent) developed a postoperative hematoma. Hematoma was not associated with intraoperative, postoperative, and perioperative ketorolac use (p > 0.43, all). Intraoperative ketorolac use was associated with lower total intraoperative dosing of fentanyl and morphine, and postoperative ketorolac use was associated with lower total postoperative doses of oxycodone and morphine (pfrom #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2O9PDXw
Measurement of Warping Angle in Human Rib Graft: An Experimental Study
Breast Implant Mycobacterial Infections: An Epidemiologic Review and Outcome Analysis
Background: Epidemiologic evidence of periprosthetic mycobacterial infections is limited. The recent boom in cosmetic surgery tourism has been associated with a rise of surgical-site infections in returning patients. This review aims to explore available data, examine trends of documented periprosthetic mycobacterial infections, and analyze outcomes of management techniques. Methods: A search in the Biosis, Embase, LILACS, MEDLINE, and Web of Science databases from inception until December of 2017 for "Breast Implants" and "Mycobacterial Infections" and equivalents was performed. Data were pooled after two screening rounds following full-text retrieval and cross-referencing. Results: Forty-one reports describing 171 female patients who had breast prosthesis–related mycobacterial infections were identified. Bibliometric case-based analysis revealed a rise of periprosthetic mycobacterial infections in developing countries since the start of the millennium. The mean patient's age was 37.9 years and the majority of patients had undergone bilateral breast augmentation. Most patients presented with breast pain or tenderness, after an average incubation period of 9 months. Mycobacterium fortuitum was isolated from 90 cases (52.6 percent). Immediate explantation with or without delayed reimplantation was the most commonly used surgical strategy, complemented by combination antimicrobial therapy for an average of 4.6 months. The mean follow-up time was 39.7 months, during which recurrence was observed in 21 of 171 patients (12.3 percent). Conclusions: The emergence of periprosthetic mycobacterial infections in relation to cosmetic medical tourism alerts clinicians to the importance of educating the public about the associated risks. In addition, this study identifies risk factors associated with recurrence of periprosthetic mycobacterial infections.from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2O8ePh0
Reply: Increasing Diversity in Plastic Surgery
Anatomy of the Superficial Fascia System of the Breast: A Comprehensive Theory of Breast Fascial Anatomy
Background: It has been two centuries since Petrus Camper identified superficial fascia and over 175 years since Sir Astley Cooper wrote his book on the anatomy of the breast. In the 1990s, Ted Lockwood taught us the importance of the superficial fascia layers in body contouring procedures he pioneered. These descriptions, however, fail to explain the three-dimensional fascial system in the breast. The authors set out to discover and describe a theory of superficial fascia structures responsible for breast shape. Methods: The nature of the superficial fascia system that surrounds the breast and its attachments to the chest were studied in 12 cadaver breast dissections and in clinical cases of both cosmetic and reconstructive breast procedures. Results: The authors found a three-dimensional, closed system of fascia and fat surrounding the corpus mammae, which attaches to the skin by means of specialized vertical cutaneous ligaments, or Cooper ligaments, and which attaches to the chest wall by means of a three-dimensional zone of adherence at the breast's periphery. Conclusions: The breast is shaped by a three-dimensional, fibrofatty fascial system. Two layers of this system surround the corpus mammae and fuse together around it, and anchor it to the chest wall in a structure we have called the circummammary ligament.from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2O9Pu6q
Ergonomics in the Operating Room: The Cervicospinal Health of Today’s Surgeons
Summary: In its many forms, operating can lead surgeons to adopt postures that have damaging long-term effects on physical health through imparting musculoskeletal fatigue. One area that is particularly susceptible is the cervical spine, as surgeons are forced into positions that require sustained cervical hyperflexion. The repercussions of resultant injuries can be steep, as they have the potential to adversely affect one's operative capacity. The purpose of this article is to assess the spinal health of today's surgeons by evaluating available research in various surgical subspecialties. By focusing on the ergonomic principles that govern the surgical arena and identifying unifying themes between plastic surgery and other surgical subspecialties, it is the goal of this article to enhance the understanding of cervical spine health as it pertains to the plastic and reconstructive surgeon.from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2yCjEKw
The Relationship between Age and Facial Asymmetry
Background: Facial symmetry is a fundamental goal of plastic surgery, yet some asymmetry is inherent in any face. Three-dimensional photogrammetry allows for rapid, reproducible, and quantitative facial measurements. With this tool, the authors investigated the relationship between age and facial symmetry. Methods: The authors imaged normal subjects using three-dimensional photogrammetry. Facial symmetry was calculated by identifying the plane of maximum symmetry and the root-mean-square deviation. Regression analysis was used to assess the relationship between age and symmetry. Subgroup analyses were performed among facial thirds. Results: The authors imaged 191 volunteers with an average age of 26.7 ± 22.2 years (range, 0.3 to 88 years). Root-mean-square deviation of facial symmetry clustered between 0.4 and 1.3 mm (mean, 0.8 ± 0.2 mm). The authors found a significant positive correlation between increasing age and asymmetry (pfrom #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2O6Aarl
Nitroglycerin Ointment for Reducing the Rate of Mastectomy Flap Necrosis in Immediate Implant-Based Breast Reconstruction: Correction
The Feasibility Determination of Risky Severe Complications of Arterial Vasculature Regarding the Filler Injection Sites at the Tear Trough
Background: The tear trough is a significant sign of periorbital aging and has usually been corrected with filler injection. However, the arterial supply surrounding the tear trough could be inadvertently injured during injection; therefore, this study aimed to evaluate the nearest arterial locations related to the tear trough and investigate the possibility of severe complications following filler injection. Methods: Thirty hemifaces of 15 Thai embalmed cadavers were used in this study. Results: The artery located closest to both the inferior margin (TT1) and mid-pupil level (TT2) of the tear trough was found to be the palpebral branch of the infraorbital artery. Furthermore, at 0.5 mm along the tear trough from the medial canthus (TT3), the angular artery was identified, which was found to be a branch of the ophthalmic artery. The artery at TT1 and TT2 was located beneath both the zygomaticus major and the orbicularis oculi muscles. The distances from TT1 to the artery were measured as follows: laterally, 2.79 ± 1.08 mm along the x axis; and inferiorly, 2.88 ± 1.57 mm along the y axis. For the TT2, the artery was located inferomedially from the landmark of 4.65 ± 1.83 mm along the x axis and 7.13 ± 3.99 mm along the y axis. However, the distance along the x axis at TT3 was located medially as 4.00 ± 2.37 mm. Conclusion: The high risk of injury to the artery at the tear trough should be considered because of the numerous arteries to this area.from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OcsB2o
Lower Body Lift in the Massive Weight Loss Patient: A New Classification and Algorithm for Gluteal Augmentation
High-Throughput Screening of Full-Face Clinically Relevant Arterial Variations Using Three-Dimensional Postmortem Computed Tomography
Background: Vascular complications resulting from intravascular filler injection and embolism are major safety concerns for facial filler injection. It is essential to systematically screen full-face arterial variations and help design evidence-based safe filler injection protocols. Methods: The carotid arteries of 22 cadaveric heads were infused with adequate lead oxide contrast. The facial and superficial temporal arteries of another 12 cadaveric heads were injected with the contrast in a sequential order. A computed tomographic scan was acquired after each contrast injection, and each three-dimensional computed tomographic scan was reconstructed using validated algorithms. Results: Three-dimensional computed tomography clearly demonstrated the course, relative depth, and anastomosis of all major arteries in 63 qualified hemifaces. The ophthalmic angiosome consistently deploys two distinctive layers of branch arteries to the forehead. The superficial temporal and superior palpebral arteries run along the preauricular and superior palpebral creases, respectively. The study found that 74.6 percent of the hemifaces had nasolabial trunks coursing along the nasolabial crease, and that 50.8 percent of the hemifaces had infraorbital trunks that ran through the infraorbital region. Fifty percent of the angular arteries were the direct anastomotic channels between the facial and ophthalmic angiosomes, and 29.2 percent of the angular arteries were members of the ophthalmic angiosomes. Conclusions: Full-face arterial variations were mapped using postmortem three-dimensional computed tomography. Facial creases were in general correlated with underlying deep arteries. Facial and angular artery variations were identified at high resolution, and reclassified into clinically relevant types to guide medical practice.from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2O5KpvS
Vascular Anomalies: From a Clinicohistologic to a Genetic Framework
Alar Cinching with Subcutaneous Flaps: A Procedure to Achieve Narrowing of the Nasal Base while Controlling the Alar Axis and Sidewall Curvature
Background: Insufficient narrowing of alar width, alar distortion, and noticeable scarring are commonly encountered after alar base reduction. The authors aimed to demonstrate an alar cinching with subcutaneous flaps procedure to reduce the alar width while controlling the alar axis and sidewall curvature. Methods: A retrospective chart review of 560 patients who underwent alar base reduction between 2000 and 2015 was performed. The clinical outcomes of alar cinching with subcutaneous flaps were compared to those of vestibular floor excision with cinching suture. Mean change in alar width was compared to assess narrowing efficacy between the two groups. In addition, mean changes in interalar distance for the upper, middle, and lower parts of the alae were compared to evaluate the alteration of alar axes. Results: Seventy-three patients who underwent alar base narrowing alone (alar cinching with subcutaneous flaps, n = 42; vestibular floor excision with cinching suture, n = 31) were identified. Alar cinching with subcutaneous flaps was significantly more effective than vestibular floor excision with cinching suture in reducing alar width. In patients with vertical alar axes, alar cinching with subcutaneous flaps achieved more uniform narrowing of the entire alae, resulting in prevention of alar distortion. The incidence of complications after alar cinching with subcutaneous flaps was 5.7 percent. Conclusions: Alar cinching with subcutaneous flaps achieved sufficient narrowing of the nasal base in the long-term follow-up in patients with any type of alar axis and enabled the reduction of sidewall curvature while eliminating the need for wedge resection. CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, III.from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2O5nQY9
Investigation and analysis of 1030 primary hair transplantation cases: a retrospective study
Abstract
Background
Hair transplantation has progressed since the introduction of the concept of follicular unit transplantation, a method that recognizes the follicular unit as the basic element of tissue to be transferred. It was aimed to estimate the area of donor scalp with the greatest probability contains the number of follicular units desired to transplant and to analyze the complications in all patients who underwent hair transplantation procedure.
Methods
A retrospective study was conducted in our clinic from January 2014 to January 2018.
Results
One thousand thirty hair restoration procedures were performed. Each patient was evaluated for age and gender in addition to the follicular unit density and postoperative complication rates. The mean age was 37.2 years. It was noted that the most common type of hair grouping was the 2-hair follicular unit grafts. The FU density ranged between 70 and 90 and the hair density ranged between 130 and 220 hair/cm2. Postoperative frontal edema was the most common postoperative complication.
Conclusions
Data collected from this series can help to estimate the area of donor scalp with the greates probability of containing the number of follicular units desired to transplant.
Level of Evidence: Level IV, therapeutic study.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2SmUKXs
Investigation and analysis of 1030 primary hair transplantation cases: a retrospective study
Abstract
Background
Hair transplantation has progressed since the introduction of the concept of follicular unit transplantation, a method that recognizes the follicular unit as the basic element of tissue to be transferred. It was aimed to estimate the area of donor scalp with the greatest probability contains the number of follicular units desired to transplant and to analyze the complications in all patients who underwent hair transplantation procedure.
Methods
A retrospective study was conducted in our clinic from January 2014 to January 2018.
Results
One thousand thirty hair restoration procedures were performed. Each patient was evaluated for age and gender in addition to the follicular unit density and postoperative complication rates. The mean age was 37.2 years. It was noted that the most common type of hair grouping was the 2-hair follicular unit grafts. The FU density ranged between 70 and 90 and the hair density ranged between 130 and 220 hair/cm2. Postoperative frontal edema was the most common postoperative complication.
Conclusions
Data collected from this series can help to estimate the area of donor scalp with the greates probability of containing the number of follicular units desired to transplant.
Level of Evidence: Level IV, therapeutic study.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2SmUKXs
Quantitative gingival crevicular fluid proteome in type 2 diabetes mellitus and chronic periodontitis
Oral Diseases, Volume 0, Issue ja, -Not available-.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2qaGMLJ
Quantitative gingival crevicular fluid proteome in type 2 diabetes mellitus and chronic periodontitis
Oral Diseases, Volume 0, Issue ja, -Not available-.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2qaGMLJ
Apical U-shape splitting technique for undercut areas of the anterior alveolar ridge: a prospective non-randomized controlled study
The aim of this study was to investigate a novel apical U-shape splitting technique for horizontal bone augmentation in undercut areas and to compare its efficacy with that of guided bone regeneration (GBR). This was a prospective non-randomized controlled clinical trial. A total of 36 patients, who presented with a labial undercut that was not able to house a normally inclined implant, underwent the new technique or GBR. Radiographic and clinical data were obtained preoperatively, immediately after surgery, and 12 months after surgery. (Source: International Journal of Oral and Maxillofacial Surgery)
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Considerations on the ‘corseting’ or ‘strangling’ technique to treat large venous malformations
We read with interest the paper entitled "Corseting: a new technique for the management of diffuse venous malformations in the head and neck region" published in the International Journal of Oral& Maxillofacial Surgery1, and found that it deals with a relevant topic. (Source: International Journal of Oral and Maxillofacial Surgery)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2CFX2f2
Apical U-shape splitting technique for undercut areas of the anterior alveolar ridge: a prospective non-randomized controlled study
The aim of this study was to investigate a novel apical U-shape splitting technique for horizontal bone augmentation in undercut areas and to compare its efficacy with that of guided bone regeneration (GBR). This was a prospective non-randomized controlled clinical trial. A total of 36 patients, who presented with a labial undercut that was not able to house a normally inclined implant, underwent the new technique or GBR. Radiographic and clinical data were obtained preoperatively, immediately after surgery, and 12 months after surgery. (Source: International Journal of Oral and Maxillofacial Surgery)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2qaoTwj
Considerations on the ‘corseting’ or ‘strangling’ technique to treat large venous malformations
We read with interest the paper entitled "Corseting: a new technique for the management of diffuse venous malformations in the head and neck region" published in the International Journal of Oral& Maxillofacial Surgery1, and found that it deals with a relevant topic. (Source: International Journal of Oral and Maxillofacial Surgery)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2CFX2f2
‘Corseting’ and ‘strangling’—two techniques sharing similar concepts to treat large venous malformations in the head and neck region
We congratulate Colletti et al. for introducing the 'strangling technique' in a preliminary report of two cases in the journal Head& Neck in October 20141. Although it shares a similar approach with the 'corset technique' in terms of the concept and the exposure of the lesion, it is very different from the corset technique2. The term itself talks about a difference in collapsing the lesion using locked vertical mattress sutures. The following narrative clearly explains the differences between t he two techniques. (Source: International Journal of Oral and Maxillofacial Surgery)
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Radiation Oncology for Head and Neck Cancer
Treatment of head and neck cancer with curative intent consists of surgery and/or radiotherapy (RT) sometimes combined with adjuvant chemotherapy depending on the tumor site, extent, and histology. Herein, the authors review the role of RT in the management of head and neck mucosal squamous cell carcinoma (SCC). The authors focus on the outcomes of definitive RT and, depending on the primary site, postoperative RT. Unless otherwise specified, outcomes data cited are from the University of Florida. (Source: Oral and Maxillofacial Surgery Clinics)
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Gene Therapy in Head and Neck Cancer
This article provides insight into some gene therapy targets and varied techniques being evaluated for patients with head and neck cancer. Techniques include corrective gene therapy, cytoreductive gene therapy, and gene editing, in addition to a discussion on gene therapy vectors. (Source: Oral and Maxillofacial Surgery Clinics)
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Oral Cavity Cancer
This article provides clinicians with a synopsis of the most contemporary management strategies for oral cavity squamous cell carcinoma, framed within the context of historical treatment philosophies. (Source: Oral and Maxillofacial Surgery Clinics)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2RdCL4z
Radiation Oncology for Head and Neck Cancer
Treatment of head and neck cancer with curative intent consists of surgery and/or radiotherapy (RT) sometimes combined with adjuvant chemotherapy depending on the tumor site, extent, and histology. Herein, the authors review the role of RT in the management of head and neck mucosal squamous cell carcinoma (SCC). The authors focus on the outcomes of definitive RT and, depending on the primary site, postoperative RT. Unless otherwise specified, outcomes data cited are from the University of Florida. (Source: Oral and Maxillofacial Surgery Clinics)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Rg61rn
Gene Therapy in Head and Neck Cancer
This article provides insight into some gene therapy targets and varied techniques being evaluated for patients with head and neck cancer. Techniques include corrective gene therapy, cytoreductive gene therapy, and gene editing, in addition to a discussion on gene therapy vectors. (Source: Oral and Maxillofacial Surgery Clinics)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2q9Zp26
Oral Cavity Cancer
This article provides clinicians with a synopsis of the most contemporary management strategies for oral cavity squamous cell carcinoma, framed within the context of historical treatment philosophies. (Source: Oral and Maxillofacial Surgery Clinics)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2RdCL4z
Re: Knowledge of final-year medical students about oral and maxillofacial surgery: a two-centre study
As medical students in our clinical years, we read with interest the article by Hamid et al.1 They used a questionnaire to assess students ' exposure to oral and maxillofacial surgery (OMFS), their knowledge of oral cancer, and their ability to refer appropriately to OMFS. They concluded that medical students are poorly engaged with OMFS and would benefit from improved awareness and understanding of the specialty. (Source: The British Journal of Oral and Maxillofacial Surgery)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Sk0xx2
Rural and urban differences in orthognathic surgical patients in the north east of Scotland
We have previously identified differences in the presentation and treatment of cancer between patients who live in rural compared with urban areas, but have not yet seen differences in those treated by orthognathic surgery. We hypothesised that patients from areas further away from the hospital face higher costs to attend and may not present with minor problems as often as those who live nearby. We therefore retrospectively reviewed all those (n=216) who had presented for orthognathic surgery over a six-year period (May 2011 to May 2017). (Source: The British Journal of Oral and Maxillofacial Surgery)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2yZwSAk
Re: Knowledge of final-year medical students about oral and maxillofacial surgery: a two-centre study
As medical students in our clinical years, we read with interest the article by Hamid et al.1 They used a questionnaire to assess students ' exposure to oral and maxillofacial surgery (OMFS), their knowledge of oral cancer, and their ability to refer appropriately to OMFS. They concluded that medical students are poorly engaged with OMFS and would benefit from improved awareness and understanding of the specialty. (Source: The British Journal of Oral and Maxillofacial Surgery)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Sk0xx2
Rural and urban differences in orthognathic surgical patients in the north east of Scotland
We have previously identified differences in the presentation and treatment of cancer between patients who live in rural compared with urban areas, but have not yet seen differences in those treated by orthognathic surgery. We hypothesised that patients from areas further away from the hospital face higher costs to attend and may not present with minor problems as often as those who live nearby. We therefore retrospectively reviewed all those (n=216) who had presented for orthognathic surgery over a six-year period (May 2011 to May 2017). (Source: The British Journal of Oral and Maxillofacial Surgery)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2yZwSAk
A skewed pool of resident T cells triggers psoriasis-associated tissue responses in never-lesional skin from patients with psoriasis
Resident T cells are implicated in the maintenance and recurrence of psoriatic lesions. Whether skin that has not yet experienced psoriasis in patients with established disease harbors pathogenic T cells is less investigated. (Source: Journal of Allergy and Clinical Immunology)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PWyp1A
ALLERGY RELIEF (Cetirizine Hcl) Capsule [ASSURED / DOLLAR TREE (Greenbrier International, Inc.)]
Updated Date: Oct 25, 2018 EST (Source: DailyMed Drug Label Updates)
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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PXcHur
Loss of Gimap5 promotes pathogenic CD4+ T cell development and allergic airway disease
GIMAP5 LOF mutations in both mice and humans are associated with polarization of CD4+ T cells towards TH17 and TH2 cells in vivo. Gimap5-deficient mice develop more severe allergic airway disease upon HDM sensitization. (Source: Journal of Allergy and Clinical Immunology)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2SigALS
Advances in Food Allergy in 2017
This review highlights research and policy advances in food allergy that were published in 2017 in the Journal and beyond. In 2017, many important studies on the treatment of food allergy were published, bringing us ever closer to a standardized treatment for food allergy. Other important advancements included research into other management strategies, including thresholds for avoidance and management of food allergies in schools were published, and development of new guidelines for prevention of food allergy. (Source: Journal of Allergy and Clinical Immunology)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2z3NEym
Supporting caregivers during hematopoietic cell transplantation for children with primary immunodeficiency disorders
Caregivers of children with primary immunodeficiencies experience unique challenges during hematopoietic cell transplantation and are at risk for poor well-being. Healthcare systems should consider facilitating peer-to-peer on-line support and targeted interventions to improve caregiver well-being among high-risk groups. (Source: Journal of Allergy and Clinical Immunology)
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Epithelial acid imbalance in patients with eosinophilic esophagitis
Eosinophilic esophagitis (EoE) is a chronic allergic inflammatory disease of the esophagus that is triggered by specific foods and, if left untreated, can result in considerable morbidity.1 Although the clinical significance of this condition is widely acknowledged, the cellular and molecular mechanisms that underlie its pathophysiology are an active area of research. The sine qua non of EoE is the presence of eosinophilic inflammation in the esophagus. However, there are other key histopathologic features of EoE that can provide important insights into the mechanisms of this disease. (Source: Journal of Allergy and Clinical Immunology)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2ArRweo
ALLERGY RELIEF (Cetirizine Hcl) Capsule [ASSURED / DOLLAR TREE (Greenbrier International, Inc.)]
Updated Date: Oct 25, 2018 EST (Source: DailyMed Drug Label Updates)
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PXcHur
Loss of Gimap5 promotes pathogenic CD4+ T cell development and allergic airway disease
GIMAP5 LOF mutations in both mice and humans are associated with polarization of CD4+ T cells towards TH17 and TH2 cells in vivo. Gimap5-deficient mice develop more severe allergic airway disease upon HDM sensitization. (Source: Journal of Allergy and Clinical Immunology)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2SigALS
Advances in Food Allergy in 2017
This review highlights research and policy advances in food allergy that were published in 2017 in the Journal and beyond. In 2017, many important studies on the treatment of food allergy were published, bringing us ever closer to a standardized treatment for food allergy. Other important advancements included research into other management strategies, including thresholds for avoidance and management of food allergies in schools were published, and development of new guidelines for prevention of food allergy. (Source: Journal of Allergy and Clinical Immunology)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2z3NEym
Epithelial acid imbalance in patients with eosinophilic esophagitis
Eosinophilic esophagitis (EoE) is a chronic allergic inflammatory disease of the esophagus that is triggered by specific foods and, if left untreated, can result in considerable morbidity.1 Although the clinical significance of this condition is widely acknowledged, the cellular and molecular mechanisms that underlie its pathophysiology are an active area of research. The sine qua non of EoE is the presence of eosinophilic inflammation in the esophagus. However, there are other key histopathologic features of EoE that can provide important insights into the mechanisms of this disease. (Source: Journal of Allergy and Clinical Immunology)
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A skewed pool of resident T cells triggers psoriasis-associated tissue responses in never-lesional skin from patients with psoriasis
Resident T cells are implicated in the maintenance and recurrence of psoriatic lesions. Whether skin that has not yet experienced psoriasis in patients with established disease harbors pathogenic T cells is less investigated. (Source: Journal of Allergy and Clinical Immunology)
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Imaging and Surgical Findings in Patients with Hemi-Laryngopharyngeal Spasm and the Potential Role of MRI in the Diagnostic Work-Up [HEAD & NECK]
BACKGROUND AND PURPOSE:
Hemi-laryngopharyngeal spasm is a recently discovered condition characterized by episodic coughing and unilateral throat contractions that may lead to severe stridor. These symptoms are caused by a vascular compression of the ipsilateral vagus nerve, typically the PICA. Microvascular decompression of the vagus nerve has been demonstrated to be a potential cure for this neurovascular compression syndrome. The main aim of this study was to clarify the role of MR imaging in the diagnostic work-up of this rare condition.
MATERIALS AND METHODS:We describe the imaging and surgical findings of 3 patients from our prospective case series of patients with hemi-laryngopharyngeal spasm from 2015 to 2017. Second, the imaging data of 100 patients (control cohort) with symptoms unrelated to hemi-laryngopharyngeal spasm were reviewed to investigate the rate and degree of neurovascular conflict of the vagus nerve.
RESULTS:All patients with hemi-laryngopharyngeal spasm reported to date have had vascular compression of the vagus nerve due to the PICA. In the control cohort, there was a good interrater agreement in scoring the "contact" and "compression" of the vagus nerve ( = 0.73. P = < .001). The frequency of contact or compression of the vagus nerve was approximately 50%. The PICA was the most frequent vessel involved in 74%.
CONCLUSIONS:The presence of unilateral neurovascular contact or compression of the vagus nerve does not confirm the diagnosis of hemi-laryngopharyngeal spasm. The MR imaging finding of ipsilateral vascular compression of the vagus nerve is a necessary but not sufficient finding for the diagnosis of hemi-laryngopharyngeal spasm.
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Perspectives on Neuroradiology Medical Expert Testimony: Fact and Fiction [PRACTICE PERSPECTIVES]
SUMMARY:
There are numerous misconceptions about serving as a medical malpractice expert witness. By maintaining an objective perspective based in the unbiased interpretation of the images provided (for both sides of the conflict), one can best serve society as a whole. Most cases for which a neuroradiology expert is recruited are the following: 1) not with the radiologist as a defendant, 2) resolved without court testimony, and 3) short-lived if frivolous. One can learn much about medicine, our nonradiology colleagues, and the litigation process by participating as an expert witness.
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Percutaneous Radiofrequency Ablation of Spinal Osteoid Osteomas Using a Targeted Navigational Bipolar Electrode System [PATIENT SAFETY]
SUMMARY:
Safe and effective percutaneous CT-guided radiofrequency ablation of spinal osteoid osteomas can be performed using a targeted navigational bipolar electrode system. Articulating bipolar electrodes with built-in thermocouples along an electrode shaft and variable generator wattage settings allow optimal nidus access, particularly in challenging locations; provide precise real-time monitoring of ablation zone volume and geometry; and minimize the risk of undesired thermal injury.
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Does the Presence or Absence of DESH Predict Outcomes in Adult Hydrocephalus? [ADULT BRAIN]
BACKGROUND AND PURPOSE:
The DESH (disproportionately enlarged subarachnoid-space hydrocephalus) pattern of "tight high-convexity and medial subarachnoid spaces, and enlarged Sylvian fissures with ventriculomegaly" is used to determine which patients undergo an operation for adult hydrocephalus at many centers. Our aim was to review adult hydrocephalus cases when DESH has not been a criterion for an operation to determine the prevalence of DESH among the cohort and compare the surgical outcomes in the presence or absence of DESH.
MATERIALS AND METHODS:A retrospective cohort study was conducted at a single institution (Johns Hopkins Hospital) to include patients surgically treated for adult hydrocephalus between 2003 and 2014 drawn from a data base of patients who had undergone standardized hydrocephalus protocol MR imaging. Preoperative imaging was reviewed by 2 blinded neuroradiologists to characterize the presence of DESH. Preoperative and postoperative clinical symptomatology was recorded. Frequencies were compared using the Fisher exact test, and nonparametric means were compared using the Mann-Whitney U Test.
RESULTS:One hundred thirty-three subjects were identified and included (96 DESH absent, 37 DESH present). Shunting led to significant improvement in gait and urinary and cognitive symptoms for the overall cohort and for patients with and without DESH (P < .05). The Fisher exact test did not demonstrate any significant differences in either gait or urinary or cognitive symptom improvement between patients with or without DESH (P > .05).
CONCLUSIONS:The current study demonstrated symptom improvement in patients with adult hydrocephalus following shunting, with no significant differences between subjects with and without DESH. Thus, shunt insertion for patients with adult hydrocephalus should not rely solely on the presence of preoperative DESH findings.
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ERRATUM [ERRATA]
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The Top 20 Most Prolific Authors in the American Journal of Neuroradiology: What Is Their Impact? [RESEARCH PERSPECTIVES]
BACKGROUND AND PURPOSE:
Many articles that are relevant to patient care but published in radiology journals may escape notice by clinicians. We sought to determine how often the 20 most prolific American Journal of Neuroradiology (AJNR) authors from 2013 to 2017 published in clinical journals and the extent to which their articles were disseminated into the clinical literature.
MATERIALS AND METHODS:We counted all authors' first- or senior-authored articles in the AJNR from 2013 to 2017 to identify the 20 most prolific authors in AJNR. We searched for these 20 authors' total articles from 2013 to 2017 to determine which were published in radiology or clinical journals and the number of citations received from radiology and clinical journals. Authors were sorted into quartiles according to these metrics, and other descriptive statistics were performed.
RESULTS:The top 20 AJNR authors contributed to 1463 articles during 5 years, including 711 (48.6%) in radiology and 752 (51.4%) in clinical journals. These articles were cited 15,857 times, including 4659 (29.3%) by articles in radiology journals. The more prolific authors published in clinical journals more often (Spearman = 0.65, P = .002) and were cited more ( = 0.42, P = .07). Articles published in clinical journals were cited more often (mean, 12.3 clinical, 9.3 radiology general versus 8.7 in AJNR), and whether published in radiology or clinical journals, they were cited more frequently by clinical journals.
CONCLUSIONS:Regardless of where it is published, radiology research is disseminating into the clinical realm. Radiology articles published in clinical journals are cited more often than those published in radiology journals.
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Peeking into the Black Box of Coregistration in Clinical fMRI: Which Registration Methods Are Used and How Well Do They Perform? [FUNCTIONAL]
BACKGROUND AND PURPOSE:
Interpretation of fMRI depends on accurate functional-to-structural alignment. This study explores registration methods used by FDA-approved software for clinical fMRI and aims to answer the following question: What is the degree of misalignment when registration is not performed, and how well do current registration methods perform?
MATERIALS AND METHODS:This retrospective study of presurgical fMRI for brain tumors compares nonregistered images and 5 registration cost functions: Hellinger, mutual information, normalized mutual information, correlation ratio, and local Pearson correlation. To adjudicate the accuracy of coregistration, we edge-enhanced echo-planar maps and rated them for alignment with structural anatomy. Lesion-to-activation distances were measured to evaluate the effects of different cost functions.
RESULTS:Transformation parameters were congruent among Hellinger, mutual information, normalized mutual information, and the correlation ratio but divergent from the local Pearson correlation. Edge-enhanced images validated the local Pearson correlation as the most accurate. Hellinger worsened misalignment in 59% of cases, primarily exaggerating the inferior translation; no cases were worsened by the local Pearson correlation. Three hundred twenty lesion-to-activation distances from 25 patients were analyzed among nonregistered images, Hellinger, and the local Pearson correlation. ANOVA analysis revealed significant differences in the coronal (P < .001) and sagittal (P = .04) planes. If registration is not performed, 8% of cases may have a >3-mm discrepancy and up to a 5.6-mm lesion-to-activation distance difference. If a poor registration method is used, 23% of cases may have a >3-mm discrepancy and up to a 6.9-mm difference.
CONCLUSIONS:The local Pearson correlation is a special-purpose cost function specifically designed for T2*–T1 coregistration and should be more widely incorporated into software tools as a better method for coregistration in clinical fMRI.
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Hemodynamic Impairment Measured by Positron-Emission Tomography Is Regionally Associated with Decreased Cortical Thickness in Moyamoya Phenomenon [ADULT BRAIN]
BACKGROUND AND PURPOSE:
Impaired cerebrovascular reactivity has been associated with decreased cortical thickness in patients with arterial occlusive diseases. This study tests the hypothesis that severe hemodynamic impairment, indicated by increased oxygen extraction fraction ratios on positron-emission tomography with 15O tracers, is associated with decreased cortical thickness in patients with Moyamoya phenomenon.
MATERIALS AND METHODS:Patients with unilateral or bilateral idiopathic Moyamoya phenomenon were recruited. Oxygen extraction fraction ratio maps were generated from cerebral images of O[15O] counts divided by H2[15O] counts with normalization by corresponding cerebellar counts. The normal range of the oxygen extraction fraction ratio was estimated from historically available healthy control subjects. Cortical thickness was estimated from T1-weighted MR imaging and FreeSurfer. Regional samples of oxygen extraction fraction ratios and cortical thicknesses were drawn using FreeSurfer parcellations, retaining only parcellations from the vascular territory of the middle cerebral artery.
RESULTS:Complete MR imaging and PET datasets were available in 35 subjects, including 23 women; the mean age at scanning was 44 years. Patients with Moyamoya phenomenon had a significantly increased regional oxygen extraction fraction ratio compared with 15 healthy control subjects (P < .001). Regional oxygen extraction fraction ratio and age were significant predictors of cortical thickness (P < .001 for each) in a generalized linear mixed-effects model. Using hemisphere averages and patient averages, we found that only age was a significant predictor of cortical thickness (P < .001).
CONCLUSIONS:Chronic hemodynamic impairment, as indicated by a higher regional oxygen extraction fraction ratio, was significantly predictive of reduced cortical thickness in mixed-effects analysis of FreeSurfer regions. This phenomenon may be related to reversible metabolic down-regulation.
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Imaging and Surgical Findings in Patients with Hemi-Laryngopharyngeal Spasm and the Potential Role of MRI in the Diagnostic Work-Up [HEAD & NECK]
BACKGROUND AND PURPOSE:
Hemi-laryngopharyngeal spasm is a recently discovered condition characterized by episodic coughing and unilateral throat contractions that may lead to severe stridor. These symptoms are caused by a vascular compression of the ipsilateral vagus nerve, typically the PICA. Microvascular decompression of the vagus nerve has been demonstrated to be a potential cure for this neurovascular compression syndrome. The main aim of this study was to clarify the role of MR imaging in the diagnostic work-up of this rare condition.
MATERIALS AND METHODS:We describe the imaging and surgical findings of 3 patients from our prospective case series of patients with hemi-laryngopharyngeal spasm from 2015 to 2017. Second, the imaging data of 100 patients (control cohort) with symptoms unrelated to hemi-laryngopharyngeal spasm were reviewed to investigate the rate and degree of neurovascular conflict of the vagus nerve.
RESULTS:All patients with hemi-laryngopharyngeal spasm reported to date have had vascular compression of the vagus nerve due to the PICA. In the control cohort, there was a good interrater agreement in scoring the "contact" and "compression" of the vagus nerve ( = 0.73. P = < .001). The frequency of contact or compression of the vagus nerve was approximately 50%. The PICA was the most frequent vessel involved in 74%.
CONCLUSIONS:The presence of unilateral neurovascular contact or compression of the vagus nerve does not confirm the diagnosis of hemi-laryngopharyngeal spasm. The MR imaging finding of ipsilateral vascular compression of the vagus nerve is a necessary but not sufficient finding for the diagnosis of hemi-laryngopharyngeal spasm.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2O7Kv6i
Perspectives on Neuroradiology Medical Expert Testimony: Fact and Fiction [PRACTICE PERSPECTIVES]
SUMMARY:
There are numerous misconceptions about serving as a medical malpractice expert witness. By maintaining an objective perspective based in the unbiased interpretation of the images provided (for both sides of the conflict), one can best serve society as a whole. Most cases for which a neuroradiology expert is recruited are the following: 1) not with the radiologist as a defendant, 2) resolved without court testimony, and 3) short-lived if frivolous. One can learn much about medicine, our nonradiology colleagues, and the litigation process by participating as an expert witness.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OS9Lmg
Percutaneous Radiofrequency Ablation of Spinal Osteoid Osteomas Using a Targeted Navigational Bipolar Electrode System [PATIENT SAFETY]
SUMMARY:
Safe and effective percutaneous CT-guided radiofrequency ablation of spinal osteoid osteomas can be performed using a targeted navigational bipolar electrode system. Articulating bipolar electrodes with built-in thermocouples along an electrode shaft and variable generator wattage settings allow optimal nidus access, particularly in challenging locations; provide precise real-time monitoring of ablation zone volume and geometry; and minimize the risk of undesired thermal injury.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2O6Yl92
ERRATUM [ERRATA]
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2O7rukf
The Top 20 Most Prolific Authors in the American Journal of Neuroradiology: What Is Their Impact? [RESEARCH PERSPECTIVES]
BACKGROUND AND PURPOSE:
Many articles that are relevant to patient care but published in radiology journals may escape notice by clinicians. We sought to determine how often the 20 most prolific American Journal of Neuroradiology (AJNR) authors from 2013 to 2017 published in clinical journals and the extent to which their articles were disseminated into the clinical literature.
MATERIALS AND METHODS:We counted all authors' first- or senior-authored articles in the AJNR from 2013 to 2017 to identify the 20 most prolific authors in AJNR. We searched for these 20 authors' total articles from 2013 to 2017 to determine which were published in radiology or clinical journals and the number of citations received from radiology and clinical journals. Authors were sorted into quartiles according to these metrics, and other descriptive statistics were performed.
RESULTS:The top 20 AJNR authors contributed to 1463 articles during 5 years, including 711 (48.6%) in radiology and 752 (51.4%) in clinical journals. These articles were cited 15,857 times, including 4659 (29.3%) by articles in radiology journals. The more prolific authors published in clinical journals more often (Spearman = 0.65, P = .002) and were cited more ( = 0.42, P = .07). Articles published in clinical journals were cited more often (mean, 12.3 clinical, 9.3 radiology general versus 8.7 in AJNR), and whether published in radiology or clinical journals, they were cited more frequently by clinical journals.
CONCLUSIONS:Regardless of where it is published, radiology research is disseminating into the clinical realm. Radiology articles published in clinical journals are cited more often than those published in radiology journals.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OOl7rj
Peeking into the Black Box of Coregistration in Clinical fMRI: Which Registration Methods Are Used and How Well Do They Perform? [FUNCTIONAL]
BACKGROUND AND PURPOSE:
Interpretation of fMRI depends on accurate functional-to-structural alignment. This study explores registration methods used by FDA-approved software for clinical fMRI and aims to answer the following question: What is the degree of misalignment when registration is not performed, and how well do current registration methods perform?
MATERIALS AND METHODS:This retrospective study of presurgical fMRI for brain tumors compares nonregistered images and 5 registration cost functions: Hellinger, mutual information, normalized mutual information, correlation ratio, and local Pearson correlation. To adjudicate the accuracy of coregistration, we edge-enhanced echo-planar maps and rated them for alignment with structural anatomy. Lesion-to-activation distances were measured to evaluate the effects of different cost functions.
RESULTS:Transformation parameters were congruent among Hellinger, mutual information, normalized mutual information, and the correlation ratio but divergent from the local Pearson correlation. Edge-enhanced images validated the local Pearson correlation as the most accurate. Hellinger worsened misalignment in 59% of cases, primarily exaggerating the inferior translation; no cases were worsened by the local Pearson correlation. Three hundred twenty lesion-to-activation distances from 25 patients were analyzed among nonregistered images, Hellinger, and the local Pearson correlation. ANOVA analysis revealed significant differences in the coronal (P < .001) and sagittal (P = .04) planes. If registration is not performed, 8% of cases may have a >3-mm discrepancy and up to a 5.6-mm lesion-to-activation distance difference. If a poor registration method is used, 23% of cases may have a >3-mm discrepancy and up to a 6.9-mm difference.
CONCLUSIONS:The local Pearson correlation is a special-purpose cost function specifically designed for T2*–T1 coregistration and should be more widely incorporated into software tools as a better method for coregistration in clinical fMRI.
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A novel allele for inducible Cre expression in germinal center B cells
European Journal of Immunology,Volume 0, Issue ja, -Not available-. (Source: European Journal of Immunology)
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
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AID and TET2 cooperation modulates FANCA expression by active demethylation in diffuse large B cell lymphoma
Clinical&Experimental Immunology,Volume 0, Issue ja, -Not available-. (Source: Clinical and Experimental Immunology)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2yZoRLK
Richard Studley Farr, MD
During the early 1960s, I was a postdoctoral fellow under the mentorship of David W. Talmage, MD. The laboratory at the University of Colorado Health Sciences Center was a crossroads for visiting allergists and immunologists from all over the world. Dr. Talmage would arrange for the fellows to meet one-on-one with many of the visitors. For some visitors, a suggestion was made to avoid discussing any work that was not well along the path to publication. When Dr. Richard Farr came to visit, the suggestion was, "you should get Dick Farr's thoughts about this." Very worthwhile advice indeed. (Source: Annals of Allergy, Asthma and Immunology)
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Supporting caregivers during hematopoietic cell transplantation for children with primary immunodeficiency disorders
Caregivers of children with primary immunodeficiencies experience unique challenges during hematopoietic cell transplantation and are at risk for poor well-being. Healthcare systems should consider facilitating peer-to-peer on-line support and targeted interventions to improve caregiver well-being among high-risk groups. (Source: Journal of Allergy and Clinical Immunology)
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Loss of Gimap5 promotes pathogenic CD4+ T cell development and allergic airway disease
GIMAP5 LOF mutations in both mice and humans are associated with polarization of CD4+ T cells towards TH17 and TH2 cells in vivo. Gimap5-deficient mice develop more severe allergic airway disease upon HDM sensitization. (Source: Journal of Allergy and Clinical Immunology)
MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
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Advances in Food Allergy in 2017
This review highlights research and policy advances in food allergy that were published in 2017 in the Journal and beyond. In 2017, many important studies on the treatment of food allergy were published, bringing us ever closer to a standardized treatment for food allergy. Other important advancements included research into other management strategies, including thresholds for avoidance and management of food allergies in schools were published, and development of new guidelines for prevention of food allergy. (Source: Journal of Allergy and Clinical Immunology)
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The cerebral endothelial cell as a key regulator of inflammatory processes in sterile inflammation
Cerebral endothelial cells accomplish numerous tasks connected to the maintenance of homeostasis of the central nervous system. They create a barrier between the central nervous system and peripheral blood and regulate mechanotransduction, vascular permeability, rheology, thrombogenesis, and leukocyte adhesion. In pathophysiological conditions (e.g., stroke or ischemia-reperfusion injury) the endothelial functions are impaired, leading to increased vascular permeability, vascular inflammation, leukocyte-endothelium interactions, and transendothelial migration, driving CNS inflammation and neuronal destruction. (Source: Journal of Neuroimmunology)
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A novel allele for inducible Cre expression in germinal center B cells
European Journal of Immunology,Volume 0, Issue ja, -Not available-. (Source: European Journal of Immunology)
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
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Altered metabolic pathways regulate synovial inflammation in Rheumatoid Arthritis
Clinical&Experimental Immunology,Volume 0, Issue ja, -Not available-. (Source: Clinical and Experimental Immunology)
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AID and TET2 cooperation modulates FANCA expression by active demethylation in diffuse large B cell lymphoma
Clinical&Experimental Immunology,Volume 0, Issue ja, -Not available-. (Source: Clinical and Experimental Immunology)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2yZoRLK
Richard Studley Farr, MD
During the early 1960s, I was a postdoctoral fellow under the mentorship of David W. Talmage, MD. The laboratory at the University of Colorado Health Sciences Center was a crossroads for visiting allergists and immunologists from all over the world. Dr. Talmage would arrange for the fellows to meet one-on-one with many of the visitors. For some visitors, a suggestion was made to avoid discussing any work that was not well along the path to publication. When Dr. Richard Farr came to visit, the suggestion was, "you should get Dick Farr's thoughts about this." Very worthwhile advice indeed. (Source: Annals of Allergy, Asthma and Immunology)
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Supporting caregivers during hematopoietic cell transplantation for children with primary immunodeficiency disorders
Caregivers of children with primary immunodeficiencies experience unique challenges during hematopoietic cell transplantation and are at risk for poor well-being. Healthcare systems should consider facilitating peer-to-peer on-line support and targeted interventions to improve caregiver well-being among high-risk groups. (Source: Journal of Allergy and Clinical Immunology)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2z3NKWK
Loss of Gimap5 promotes pathogenic CD4+ T cell development and allergic airway disease
GIMAP5 LOF mutations in both mice and humans are associated with polarization of CD4+ T cells towards TH17 and TH2 cells in vivo. Gimap5-deficient mice develop more severe allergic airway disease upon HDM sensitization. (Source: Journal of Allergy and Clinical Immunology)
MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2SigALS
Advances in Food Allergy in 2017
This review highlights research and policy advances in food allergy that were published in 2017 in the Journal and beyond. In 2017, many important studies on the treatment of food allergy were published, bringing us ever closer to a standardized treatment for food allergy. Other important advancements included research into other management strategies, including thresholds for avoidance and management of food allergies in schools were published, and development of new guidelines for prevention of food allergy. (Source: Journal of Allergy and Clinical Immunology)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2z3NEym
The cerebral endothelial cell as a key regulator of inflammatory processes in sterile inflammation
Cerebral endothelial cells accomplish numerous tasks connected to the maintenance of homeostasis of the central nervous system. They create a barrier between the central nervous system and peripheral blood and regulate mechanotransduction, vascular permeability, rheology, thrombogenesis, and leukocyte adhesion. In pathophysiological conditions (e.g., stroke or ischemia-reperfusion injury) the endothelial functions are impaired, leading to increased vascular permeability, vascular inflammation, leukocyte-endothelium interactions, and transendothelial migration, driving CNS inflammation and neuronal destruction. (Source: Journal of Neuroimmunology)
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Comparative Evaluation of QuantiFERON-TB Gold In-Tube and QuantiFERON-TB Gold Plus in Diagnosis of Latent Tuberculosis Infection in Immunocompromised Patients [Mycobacteriology and Aerobic Actinomycetes]
QuantiFERON-TB Gold Plus (QFT-Plus) is a new-generation QuantiFERON-TB Gold In-Tube (QFT-GIT) assay which has two antigen-coated tubes called TB1, which contains long peptides derived from ESAT-6 and CFP-10, and TB2, which contains the same components as TB1 and additional short peptides which potentially stimulate CD8+ T cells through the presentation of major histocompatibility complex class I. This is the first study to compare QFT-Plus and QFT-GIT for use in the diagnosis of latent tuberculosis infection (LTBI) among immunocompromised patients in the Republic of Korea. Among 317 consecutive patients who underwent screening for LTBI before solid organ or hematopoietic stem cell transplantation and tumor necrosis factor alpha inhibitor treatment, LTBI was identified in 92 (29.0%) and 88 ...
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Comparative Evaluation of QuantiFERON-TB Gold In-Tube and QuantiFERON-TB Gold Plus in Diagnosis of Latent Tuberculosis Infection in Immunocompromised Patients [Mycobacteriology and Aerobic Actinomycetes]
QuantiFERON-TB Gold Plus (QFT-Plus) is a new-generation QuantiFERON-TB Gold In-Tube (QFT-GIT) assay which has two antigen-coated tubes called TB1, which contains long peptides derived from ESAT-6 and CFP-10, and TB2, which contains the same components as TB1 and additional short peptides which potentially stimulate CD8+ T cells through the presentation of major histocompatibility complex class I. This is the first study to compare QFT-Plus and QFT-GIT for use in the diagnosis of latent tuberculosis infection (LTBI) among immunocompromised patients in the Republic of Korea. Among 317 consecutive patients who underwent screening for LTBI before solid organ or hematopoietic stem cell transplantation and tumor necrosis factor alpha inhibitor treatment, LTBI was identified in 92 (29.0%) and 88 ...
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Management of Squamous Cell Carcinoma Involving the Temporal Bone
Abstract
Purpose of Review
To examine contemporary management of squamous cell carcinoma (SCC) involving the temporal bone.
Recent Findings
The modified Pittsburgh criteria have gained acceptance by many institutions for staging, planning treatment and comparing outcomes. Often primary SCC as well as secondary cutaneous SCC involving the temporal bone can be managed in a similar fashion.
Summary
T1 tumours should undergo lateral temporal bone resection (LTBR) due to the higher risk of positive margins and recurrence rates with lesser surgical procedures. T2 tumours require LTBR and superficial parotidectomy. T3 and T4 tumours often require a subtotal resection of the temporal bone (STBR), parotidectomy and cutaneous soft tissues as an en bloc excision. Advanced lesions are associated with a diminished survival especially if margins are involved. Patient outcomes are improved by a combination of surgery and postoperative radiotherapy. Preoperative imaging with high resolution CT and MRI is useful, particularly if there is evidence of large nerve perineural spread and nodal disease.
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Management of Squamous Cell Carcinoma Involving the Temporal Bone
Abstract
Purpose of Review
To examine contemporary management of squamous cell carcinoma (SCC) involving the temporal bone.
Recent Findings
The modified Pittsburgh criteria have gained acceptance by many institutions for staging, planning treatment and comparing outcomes. Often primary SCC as well as secondary cutaneous SCC involving the temporal bone can be managed in a similar fashion.
Summary
T1 tumours should undergo lateral temporal bone resection (LTBR) due to the higher risk of positive margins and recurrence rates with lesser surgical procedures. T2 tumours require LTBR and superficial parotidectomy. T3 and T4 tumours often require a subtotal resection of the temporal bone (STBR), parotidectomy and cutaneous soft tissues as an en bloc excision. Advanced lesions are associated with a diminished survival especially if margins are involved. Patient outcomes are improved by a combination of surgery and postoperative radiotherapy. Preoperative imaging with high resolution CT and MRI is useful, particularly if there is evidence of large nerve perineural spread and nodal disease.
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Letter to the Editor
The article by Donoff and Troulis1 reviewed the development of dual degree oral and maxillofacial surgery (OMS) programs. The authors stated that this "was not without controversy." As a mid-octogenarian who survived that contentious era of both inter- and intraprofessional conflict, I add my personal experience and historical perspective. It is both a lament and a celebration, as well as a cautionary tale.
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Letter to the Editor
The article by Donoff and Troulis1 reviewed the development of dual degree oral and maxillofacial surgery (OMS) programs. The authors stated that this "was not without controversy." As a mid-octogenarian who survived that contentious era of both inter- and intraprofessional conflict, I add my personal experience and historical perspective. It is both a lament and a celebration, as well as a cautionary tale.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2O6p45i
Letter to the Editor
The article by Donoff and Troulis1 reviewed the development of dual degree oral and maxillofacial surgery (OMS) programs. The authors stated that this "was not without controversy." As a mid-octogenarian who survived that contentious era of both inter- and intraprofessional conflict, I add my personal experience and historical perspective. It is both a lament and a celebration, as well as a cautionary tale.
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Letter to the Editor
The article by Donoff and Troulis1 reviewed the development of dual degree oral and maxillofacial surgery (OMS) programs. The authors stated that this "was not without controversy." As a mid-octogenarian who survived that contentious era of both inter- and intraprofessional conflict, I add my personal experience and historical perspective. It is both a lament and a celebration, as well as a cautionary tale.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2O6p45i
Management of Squamous Cell Carcinoma Involving the Temporal Bone
Abstract
Purpose of Review
To examine contemporary management of squamous cell carcinoma (SCC) involving the temporal bone.
Recent Findings
The modified Pittsburgh criteria have gained acceptance by many institutions for staging, planning treatment and comparing outcomes. Often primary SCC as well as secondary cutaneous SCC involving the temporal bone can be managed in a similar fashion.
Summary
T1 tumours should undergo lateral temporal bone resection (LTBR) due to the higher risk of positive margins and recurrence rates with lesser surgical procedures. T2 tumours require LTBR and superficial parotidectomy. T3 and T4 tumours often require a subtotal resection of the temporal bone (STBR), parotidectomy and cutaneous soft tissues as an en bloc excision. Advanced lesions are associated with a diminished survival especially if margins are involved. Patient outcomes are improved by a combination of surgery and postoperative radiotherapy. Preoperative imaging with high resolution CT and MRI is useful, particularly if there is evidence of large nerve perineural spread and nodal disease.
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Prior to Initiation of Chemotherapy, Can We Predict Breast Tumor Response? Deep Learning Convolutional Neural Networks Approach Using a Breast MRI Tumor Dataset
Abstract
We hypothesize that convolutional neural networks (CNN) can be used to predict neoadjuvant chemotherapy (NAC) response using a breast MRI tumor dataset prior to initiation of chemotherapy. An institutional review board-approved retrospective review of our database from January 2009 to June 2016 identified 141 locally advanced breast cancer patients who (1) underwent breast MRI prior to the initiation of NAC, (2) successfully completed adriamycin/taxane-based NAC, and (3) underwent surgical resection with available final surgical pathology data. Patients were classified into three groups based on their NAC response confirmed on final surgical pathology: complete (group 1), partial (group 2), and no response/progression (group 3). A total of 3107 volumetric slices of 141 tumors were evaluated. Breast tumor was identified on first T1 postcontrast dynamic images and underwent 3D segmentation. CNN consisted of ten convolutional layers, four max-pooling layers, and dropout of 50% after a fully connected layer. Dropout, augmentation, and L2 regularization were implemented to prevent overfitting of data. Non-linear functions were modeled by a rectified linear unit (ReLU). Batch normalization was used between the convolutional and ReLU layers to limit drift of layer activations during training. A three-class neoadjuvant prediction model was evaluated (group 1, group 2, or group 3). The CNN achieved an overall accuracy of 88% in three-class prediction of neoadjuvant treatment response. Three-class prediction discriminating one group from the other two was analyzed. Group 1 had a specificity of 95.1% ± 3.1%, sensitivity of 73.9% ± 4.5%, and accuracy of 87.7% ± 0.6%. Group 2 (partial response) had a specificity of 91.6% ± 1.3%, sensitivity of 82.4% ± 2.7%, and accuracy of 87.7% ± 0.6%. Group 3 (no response/progression) had a specificity of 93.4% ± 2.9%, sensitivity of 76.8% ± 5.7%, and accuracy of 87.8% ± 0.6%. It is feasible for current deep CNN architectures to be trained to predict NAC treatment response using a breast MRI dataset obtained prior to initiation of chemotherapy. Larger dataset will likely improve our prediction model.
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Content-Based Image Retrieval System for Pulmonary Nodules Using Optimal Feature Sets and Class Membership-Based Retrieval
Abstract
Lung cancer manifests itself in the form of lung nodules, the diagnosis of which is essential to plan the treatment. Automated retrieval of nodule cases will assist the budding radiologists in self-learning and differential diagnosis. This paper presents a content-based image retrieval (CBIR) system for lung nodules using optimal feature sets and learning to enhance the performance of retrieval. The classifiers with more features suffer from the curse of dimensionality. Like classification schemes, we found that the optimal feature set selected using the minimal-redundancy-maximal-relevance (mRMR) feature selection technique improves the precision performance of simple distance-based retrieval (SDR). The performance of the classifier is always superior to SDR, which leans researchers towards conventional classifier-based retrieval (CCBR). While CCBR improves the average precision and provides 100% precision for correct classification, it fails for misclassification leading to zero retrieval precision. The class membership-based retrieval (CMR) is found to bridge this gap for texture-based retrieval. Here, CMR is proposed for nodule retrieval using shape-, margin-, and texture-based features. It is found again that optimal feature set is important for the classifier used in CMR as well as for the feature set used for retrieval, which may lead to different feature sets. The proposed system is evaluated using two independent databases from two continents: a public database LIDC/IDRI and a private database PGIMER-IITKGP, using three distance metrics, i.e., Canberra, City block, and Euclidean. The proposed CMR-based retrieval system with optimal feature sets performs better than CCBR and SDR with optimal features in terms of average precision. Apart from average precision and standard deviation of precision, the fraction of queries with zero precision retrieval is also measured.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PXI0VF
Management of Squamous Cell Carcinoma Involving the Temporal Bone
Abstract
Purpose of Review
To examine contemporary management of squamous cell carcinoma (SCC) involving the temporal bone.
Recent Findings
The modified Pittsburgh criteria have gained acceptance by many institutions for staging, planning treatment and comparing outcomes. Often primary SCC as well as secondary cutaneous SCC involving the temporal bone can be managed in a similar fashion.
Summary
T1 tumours should undergo lateral temporal bone resection (LTBR) due to the higher risk of positive margins and recurrence rates with lesser surgical procedures. T2 tumours require LTBR and superficial parotidectomy. T3 and T4 tumours often require a subtotal resection of the temporal bone (STBR), parotidectomy and cutaneous soft tissues as an en bloc excision. Advanced lesions are associated with a diminished survival especially if margins are involved. Patient outcomes are improved by a combination of surgery and postoperative radiotherapy. Preoperative imaging with high resolution CT and MRI is useful, particularly if there is evidence of large nerve perineural spread and nodal disease.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2SjOKPy
Prior to Initiation of Chemotherapy, Can We Predict Breast Tumor Response? Deep Learning Convolutional Neural Networks Approach Using a Breast MRI Tumor Dataset
Abstract
We hypothesize that convolutional neural networks (CNN) can be used to predict neoadjuvant chemotherapy (NAC) response using a breast MRI tumor dataset prior to initiation of chemotherapy. An institutional review board-approved retrospective review of our database from January 2009 to June 2016 identified 141 locally advanced breast cancer patients who (1) underwent breast MRI prior to the initiation of NAC, (2) successfully completed adriamycin/taxane-based NAC, and (3) underwent surgical resection with available final surgical pathology data. Patients were classified into three groups based on their NAC response confirmed on final surgical pathology: complete (group 1), partial (group 2), and no response/progression (group 3). A total of 3107 volumetric slices of 141 tumors were evaluated. Breast tumor was identified on first T1 postcontrast dynamic images and underwent 3D segmentation. CNN consisted of ten convolutional layers, four max-pooling layers, and dropout of 50% after a fully connected layer. Dropout, augmentation, and L2 regularization were implemented to prevent overfitting of data. Non-linear functions were modeled by a rectified linear unit (ReLU). Batch normalization was used between the convolutional and ReLU layers to limit drift of layer activations during training. A three-class neoadjuvant prediction model was evaluated (group 1, group 2, or group 3). The CNN achieved an overall accuracy of 88% in three-class prediction of neoadjuvant treatment response. Three-class prediction discriminating one group from the other two was analyzed. Group 1 had a specificity of 95.1% ± 3.1%, sensitivity of 73.9% ± 4.5%, and accuracy of 87.7% ± 0.6%. Group 2 (partial response) had a specificity of 91.6% ± 1.3%, sensitivity of 82.4% ± 2.7%, and accuracy of 87.7% ± 0.6%. Group 3 (no response/progression) had a specificity of 93.4% ± 2.9%, sensitivity of 76.8% ± 5.7%, and accuracy of 87.8% ± 0.6%. It is feasible for current deep CNN architectures to be trained to predict NAC treatment response using a breast MRI dataset obtained prior to initiation of chemotherapy. Larger dataset will likely improve our prediction model.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PoTwfP
Content-Based Image Retrieval System for Pulmonary Nodules Using Optimal Feature Sets and Class Membership-Based Retrieval
Abstract
Lung cancer manifests itself in the form of lung nodules, the diagnosis of which is essential to plan the treatment. Automated retrieval of nodule cases will assist the budding radiologists in self-learning and differential diagnosis. This paper presents a content-based image retrieval (CBIR) system for lung nodules using optimal feature sets and learning to enhance the performance of retrieval. The classifiers with more features suffer from the curse of dimensionality. Like classification schemes, we found that the optimal feature set selected using the minimal-redundancy-maximal-relevance (mRMR) feature selection technique improves the precision performance of simple distance-based retrieval (SDR). The performance of the classifier is always superior to SDR, which leans researchers towards conventional classifier-based retrieval (CCBR). While CCBR improves the average precision and provides 100% precision for correct classification, it fails for misclassification leading to zero retrieval precision. The class membership-based retrieval (CMR) is found to bridge this gap for texture-based retrieval. Here, CMR is proposed for nodule retrieval using shape-, margin-, and texture-based features. It is found again that optimal feature set is important for the classifier used in CMR as well as for the feature set used for retrieval, which may lead to different feature sets. The proposed system is evaluated using two independent databases from two continents: a public database LIDC/IDRI and a private database PGIMER-IITKGP, using three distance metrics, i.e., Canberra, City block, and Euclidean. The proposed CMR-based retrieval system with optimal feature sets performs better than CCBR and SDR with optimal features in terms of average precision. Apart from average precision and standard deviation of precision, the fraction of queries with zero precision retrieval is also measured.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PXI0VF
HPV vaccine gains support of ADA
Source: Multi Briefs Date: October 24th, 2018 Author: Tammy Adams The American Cancer Society estimates there will be more than 50,000 […]
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Lowering Radiation Dose Could Improve QoL, Cut Costs in Oral Ca
Source: MedPage Today, Medpage.com Date: October 25th, 2018 Author: Elizabeth Hlavinka SAN ANTONIO — Radiation de-intensification was tied to a quicker […]
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Antibiotic Sensitivity Pattern of Bacterial Isolates in Patients with Chronic Rhinosinusitis in Kaduna, Nigeria
Int Arch Otorhinolaryngol
DOI: 10.1055/s-0038-1673676
Introduction A common practice in the management of patients with chronic rhinosinusitis (CRS), the empirical use of antibiotics may contribute to treatment failure and to the development of antimicrobial resistance. Objective To determine the antibiotic sensitivity pattern of aerobic and anaerobic bacteria associated with CRS. Methods This was a prospective cross-sectional study in which endoscopically guided middle meatal swabs (IBM Spss, version 16.0, Chicago, IL, USA) were aseptically taken from patients diagnosed with CRS after obtaining informed consent and ethical clearance. The samples were sent to the laboratory for qualitative and semiquantitative analysis via gram stain, aerobic, anaerobic cultures and antibacterial sensitivity tests. The collected data was analyzed using SPSS for Windows, version 16 (SPSS Inc, Chicago, IL, USA). Simple statistical parameters and paired sample t-test were used, as appropriate. Results There were 74 (56.92%) bacterial growths, out of which 55 (74.32%) were aerobic and 19 (25.68%) were anaerobic isolates, from a total of 130 patients. About 13 (17.5%–18%) of these bacterial growths yielded a mixed growth of aerobic and anaerobic isolates. The most common bacterial isolates were 26 (35.14%) Staphylococcus aureus, Haemophilus influenzae 9 (12.16%), Streptococcus viridians 8 (10.81%), and Streptococcus pneumoniae 5 (6.76%). Augmentin, ciprofloxacin, and Peflacine were found to be most effective, followed by levofloxacin, Rocephin, erythromycin and Zinat in that order. Conclusion Augmentin, ciprofloxacin and Peflacine have a sensitivity of 100%, while most of the organisms show resistance to Ampiclox, amoxicillin, and Septrin.
[...]
Thieme Publicações Ltda Rio de Janeiro, Brazil
Article in Thieme eJournals:
Table of contents | Abstract | open access Full text
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HPV vaccine gains support of ADA
Source: Multi Briefs Date: October 24th, 2018 Author: Tammy Adams The American Cancer Society estimates there will be more than 50,000 […]
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2z458e9
Lowering Radiation Dose Could Improve QoL, Cut Costs in Oral Ca
Source: MedPage Today, Medpage.com Date: October 25th, 2018 Author: Elizabeth Hlavinka SAN ANTONIO — Radiation de-intensification was tied to a quicker […]
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OQW0E8
Antibiotic Sensitivity Pattern of Bacterial Isolates in Patients with Chronic Rhinosinusitis in Kaduna, Nigeria
Int Arch Otorhinolaryngol
DOI: 10.1055/s-0038-1673676
Introduction A common practice in the management of patients with chronic rhinosinusitis (CRS), the empirical use of antibiotics may contribute to treatment failure and to the development of antimicrobial resistance. Objective To determine the antibiotic sensitivity pattern of aerobic and anaerobic bacteria associated with CRS. Methods This was a prospective cross-sectional study in which endoscopically guided middle meatal swabs (IBM Spss, version 16.0, Chicago, IL, USA) were aseptically taken from patients diagnosed with CRS after obtaining informed consent and ethical clearance. The samples were sent to the laboratory for qualitative and semiquantitative analysis via gram stain, aerobic, anaerobic cultures and antibacterial sensitivity tests. The collected data was analyzed using SPSS for Windows, version 16 (SPSS Inc, Chicago, IL, USA). Simple statistical parameters and paired sample t-test were used, as appropriate. Results There were 74 (56.92%) bacterial growths, out of which 55 (74.32%) were aerobic and 19 (25.68%) were anaerobic isolates, from a total of 130 patients. About 13 (17.5%–18%) of these bacterial growths yielded a mixed growth of aerobic and anaerobic isolates. The most common bacterial isolates were 26 (35.14%) Staphylococcus aureus, Haemophilus influenzae 9 (12.16%), Streptococcus viridians 8 (10.81%), and Streptococcus pneumoniae 5 (6.76%). Augmentin, ciprofloxacin, and Peflacine were found to be most effective, followed by levofloxacin, Rocephin, erythromycin and Zinat in that order. Conclusion Augmentin, ciprofloxacin and Peflacine have a sensitivity of 100%, while most of the organisms show resistance to Ampiclox, amoxicillin, and Septrin.
[...]
Thieme Publicações Ltda Rio de Janeiro, Brazil
Article in Thieme eJournals:
Table of contents | Abstract | open access Full text
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HPV vaccine gains support of ADA
Source: Multi Briefs Date: October 24th, 2018 Author: Tammy Adams The American Cancer Society estimates there will be more than 50,000 […]
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2z458e9
Rural and urban differences in orthognathic surgical patients in the north east of Scotland
We have previously identified differences in the presentation and treatment of cancer between patients who live in rural compared with urban areas, but have not yet seen differences in those treated by orthognathic surgery. We hypothesised that patients from areas further away from the hospital face higher costs to attend and may not present with minor problems as often as those who live nearby. We therefore retrospectively reviewed all those (n=216) who had presented for orthognathic surgery over a six-year period (May 2011 to May 2017).
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Re: Knowledge of final-year medical students about oral and maxillofacial surgery: a two-centre study
As medical students in our clinical years, we read with interest the article by Hamid et al.1 They used a questionnaire to assess students' exposure to oral and maxillofacial surgery (OMFS), their knowledge of oral cancer, and their ability to refer appropriately to OMFS. They concluded that medical students are poorly engaged with OMFS and would benefit from improved awareness and understanding of the specialty.
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More Press Coverage from the 88th Annual Meeting of the ATA
From endocrineweb
Combination Immunotherapies to Treat Advanced Thyroid Cancers
Diet for Thyroid Disease: What You Need to Know
Matching Expectations and Guidelines to Treatment-Worthy Thyroid Cancers
Liver Failure: A Turning Point in Graves' Disease Treatment
The post More Press Coverage from the 88th Annual Meeting of the ATA appeared first on American Thyroid Association.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2RhD8v8
Rural and urban differences in orthognathic surgical patients in the north east of Scotland
We have previously identified differences in the presentation and treatment of cancer between patients who live in rural compared with urban areas, but have not yet seen differences in those treated by orthognathic surgery. We hypothesised that patients from areas further away from the hospital face higher costs to attend and may not present with minor problems as often as those who live nearby. We therefore retrospectively reviewed all those (n=216) who had presented for orthognathic surgery over a six-year period (May 2011 to May 2017).
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OS7lEf
Re: Knowledge of final-year medical students about oral and maxillofacial surgery: a two-centre study
As medical students in our clinical years, we read with interest the article by Hamid et al.1 They used a questionnaire to assess students' exposure to oral and maxillofacial surgery (OMFS), their knowledge of oral cancer, and their ability to refer appropriately to OMFS. They concluded that medical students are poorly engaged with OMFS and would benefit from improved awareness and understanding of the specialty.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Rd4iTN
More Press Coverage from the 88th Annual Meeting of the ATA
From endocrineweb
Combination Immunotherapies to Treat Advanced Thyroid Cancers
Diet for Thyroid Disease: What You Need to Know
Matching Expectations and Guidelines to Treatment-Worthy Thyroid Cancers
Liver Failure: A Turning Point in Graves' Disease Treatment
The post More Press Coverage from the 88th Annual Meeting of the ATA appeared first on American Thyroid Association.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2RhD8v8
Poplar catkin-derived self-templated synthesis of N-doped hierarchical porous carbon microtubes for effective CO2 capture
Publication date: 15 February 2019Source: Chemical Engineering Journal, Volume 358Author(s): Binbin Chang, Weiwei Shi, Hang Yin, Shouren Zhang, Baocheng YangAbstractPoplar catkins are an environmental pollutant because they can trigger sneezing, shortness of breath, skin allergy and even cause forest fire. It is very attractive to discover ways for reducing the threats of poplar catkins to the environment and human health and even to convert poplar catkins into useful materials. Herein we report on a facile and cost-efficient strategy for the synthesis of hierarchical porous carbon microtubes using poplar catkins as the carbon source. The synthesis involves pre-carbonization and subsequent ZnCl2 activation. The resultant materials not only inherit the natural tubular morphology of poplar c...
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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2ywQa0I
Diet and Psychosis: A Scoping Review
Discussion: Overall, these findings were consistent with many other bodies of knowledge about healthy dietary patterns. Many limitations exist related to the design of the individual studies and the ability to extrapolate the results of studies using dietary supplements to dietary interventions (food). Dietary recommendations are presented as well as recommendations for further research including more prospective observational studies and intervention studies that modify diet constituents or entire dietary patterns with statistical power to detect mental health outcomes.Neuropsychobiology (Source: Neuropsychobiology)
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Role of contrast-enhanced ultrasound (CEUS) in the diagnosis and management of traumatic splenic injuries
AbstractSplenic injuries are common emergencies in the setting of abdominal trauma, as the spleen is the second most frequently injured abdominal organ after the liver. The treatment of splenic injuries underwent a severe shift from operative to non-operative due to an increased awareness of the double physiological function, both immunological and hematological, of the spleen. This, in turn, led to an increased application of splenic preservation techniques. The non-operative approach has been strengthened through radiological imaging and interventional radiology. While multidetector computed tomography is mandatory in the evaluation of hemodynamically stable patients after high-energy trauma, one ultrasound (US) can be used as a first-line technique to examine patients in cases of low-en...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2yuSCov
Poplar catkin-derived self-templated synthesis of N-doped hierarchical porous carbon microtubes for effective CO2 capture
Publication date: 15 February 2019Source: Chemical Engineering Journal, Volume 358Author(s): Binbin Chang, Weiwei Shi, Hang Yin, Shouren Zhang, Baocheng YangAbstractPoplar catkins are an environmental pollutant because they can trigger sneezing, shortness of breath, skin allergy and even cause forest fire. It is very attractive to discover ways for reducing the threats of poplar catkins to the environment and human health and even to convert poplar catkins into useful materials. Herein we report on a facile and cost-efficient strategy for the synthesis of hierarchical porous carbon microtubes using poplar catkins as the carbon source. The synthesis involves pre-carbonization and subsequent ZnCl2 activation. The resultant materials not only inherit the natural tubular morphology of poplar c...
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2ywQa0I
Diet and Psychosis: A Scoping Review
Discussion: Overall, these findings were consistent with many other bodies of knowledge about healthy dietary patterns. Many limitations exist related to the design of the individual studies and the ability to extrapolate the results of studies using dietary supplements to dietary interventions (food). Dietary recommendations are presented as well as recommendations for further research including more prospective observational studies and intervention studies that modify diet constituents or entire dietary patterns with statistical power to detect mental health outcomes.Neuropsychobiology (Source: Neuropsychobiology)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2O6SXm8
Role of contrast-enhanced ultrasound (CEUS) in the diagnosis and management of traumatic splenic injuries
AbstractSplenic injuries are common emergencies in the setting of abdominal trauma, as the spleen is the second most frequently injured abdominal organ after the liver. The treatment of splenic injuries underwent a severe shift from operative to non-operative due to an increased awareness of the double physiological function, both immunological and hematological, of the spleen. This, in turn, led to an increased application of splenic preservation techniques. The non-operative approach has been strengthened through radiological imaging and interventional radiology. While multidetector computed tomography is mandatory in the evaluation of hemodynamically stable patients after high-energy trauma, one ultrasound (US) can be used as a first-line technique to examine patients in cases of low-en...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2yuSCov
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