Epithelial acid imbalance in patients with eosinophilic esophagitis

Eosinophilic esophagitis (EoE) is a chronic allergic inflammatory disease of the esophagus that is triggered by specific foods and, if left untreated, can result in considerable morbidity.1 Although the clinical significance of this condition is widely acknowledged, the cellular and molecular mechanisms that underlie its pathophysiology are an active area of research. The sine qua non of EoE is the presence of eosinophilic inflammation in the esophagus. However, there are other key histopathologic features of EoE that can provide important insights into the mechanisms of this disease. (Source: Journal of Allergy and Clinical Immunology)

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