Arc of Bühler: the surgical significance of a rare anatomical variation

Abstract

Purpose

The arc of Bühler, an anastomotic vessel between celiac artery and superior mesenteric artery, is a rare anatomic variation. Various radiologic and surgical procedures can be affected by its existence. We aim to review all available information and identify possible clinical implications.

Methods

A systematic review was conducted in accordance to the Preferred Reporting Items for Systematic reviews and Meta-Analysis (PRISMA) guidelines. The following terms were utilized in various combinations: "Bühler", "arc of Bühler", "visceral aneurysm", "pancreaticoduodenal arcades".

Results

Only 53 cases have been described until today in the literature. The arc of Bühler enhances collateral circulation between celiac artery and superior mesenteric artery alongside with pancreaticoduodenal arcades and dorsal pancreatic artery. Computerized tomography and angiography are the main studies used for its detection and evaluation. Aneurysms of Bühler's arc have been rarely described and seem to share common pathophysiological mechanisms with aneurysms of the pancreaticoduodenal arcades.

Conclusions

Various radiologic and surgical procedures such as embolization or pancreaticoduodenectomy are potentially affected by its existence.

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Efficacy and safety of primary surgery with postoperative radiotherapy | CMAR - Dove Medical Press

Efficacy and safety of primary surgery with postoperative radiotherapy | CMAR  Dove Medical Press

Efficacy and safety of primary surgery with postoperative radiotherapy in head and neck mucosal melanoma: a single-arm Phase II study Ji-Jin Yao,1,2,* Fan ...

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Missouri man transforms his life from jail to ultramarathons - WDRB

Missouri man transforms his life from jail to ultramarathons  WDRB

COLUMBIA, Mo. (AP) — On a crisp October night, at least 20 people gathered in Three Creeks Conservation Area for the last run of the season. As he does for.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PBCh72

Arc of Bühler: the surgical significance of a rare anatomical variation

Abstract

Purpose

The arc of Bühler, an anastomotic vessel between celiac artery and superior mesenteric artery, is a rare anatomic variation. Various radiologic and surgical procedures can be affected by its existence. We aim to review all available information and identify possible clinical implications.

Methods

A systematic review was conducted in accordance to the Preferred Reporting Items for Systematic reviews and Meta-Analysis (PRISMA) guidelines. The following terms were utilized in various combinations: "Bühler", "arc of Bühler", "visceral aneurysm", "pancreaticoduodenal arcades".

Results

Only 53 cases have been described until today in the literature. The arc of Bühler enhances collateral circulation between celiac artery and superior mesenteric artery alongside with pancreaticoduodenal arcades and dorsal pancreatic artery. Computerized tomography and angiography are the main studies used for its detection and evaluation. Aneurysms of Bühler's arc have been rarely described and seem to share common pathophysiological mechanisms with aneurysms of the pancreaticoduodenal arcades.

Conclusions

Various radiologic and surgical procedures such as embolization or pancreaticoduodenectomy are potentially affected by its existence.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Pz4UC1

Efficacy and safety of primary surgery with postoperative radiotherapy | CMAR - Dove Medical Press

Efficacy and safety of primary surgery with postoperative radiotherapy | CMAR  Dove Medical Press

Efficacy and safety of primary surgery with postoperative radiotherapy in head and neck mucosal melanoma: a single-arm Phase II study Ji-Jin Yao,1,2,* Fan ...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2SQjfMt

Missouri man transforms his life from jail to ultramarathons - WDRB

Missouri man transforms his life from jail to ultramarathons  WDRB

COLUMBIA, Mo. (AP) — On a crisp October night, at least 20 people gathered in Three Creeks Conservation Area for the last run of the season. As he does for.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PBCh72

Dog the Bounty Hunter tells fans to 'pray' for his wife, Beth, who has throat cancer - Yahoo Entertainment

Dog the Bounty Hunter tells fans to 'pray' for his wife, Beth, who has throat cancer  Yahoo Entertainment

Here's what you need to know about her battle with throat cancer.

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Study: Excess body weight behind 4% of cancers worldwide - Channel3000.com - WISC-TV3

Study: Excess body weight behind 4% of cancers worldwide  Channel3000.com - WISC-TV3

Excess body weight was responsible for 3.9% of cancer globally, or 544300 cases, in 2012, according to a new report.

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Study: Excess body weight behind 4% of cancers worldwide - Channel3000.com - WISC-TV3

Study: Excess body weight behind 4% of cancers worldwide  Channel3000.com - WISC-TV3

Excess body weight was responsible for 3.9% of cancer globally, or 544300 cases, in 2012, according to a new report.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2UKdnGm

Dog the Bounty Hunter tells fans to 'pray' for his wife, Beth, who has throat cancer - Yahoo Entertainment

Dog the Bounty Hunter tells fans to 'pray' for his wife, Beth, who has throat cancer  Yahoo Entertainment

Here's what you need to know about her battle with throat cancer.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Bgars2

Application of low-cost fused deposition modeling additive manufacturing rapid anatomic models in patients with rhino-cerebral mucormycosis treated with maxillectomy

Abstract

Mucormycosis is a fungal infection mainly of immunocompromised patients. It has many clinical manifestations depending on the system that is affected. Rhinocerebral mucormycosis and pulmonary infection are the most common. In this pathology, the fungi invade the endothelium of the blood vessels with partial or total obliteration, with tissue ischemia and necrosis. The initial symptoms are unspecific making difficult to identify from other infections and need an expert suspicion level. The gold standard is the culture of the fungi; histopathology analysis shows empty hyphae with thin walls. Combined treatment is strongly recommended surgical extended debridement and Amphotericin B is the gold standard of treatment. The craniofacial skeleton (CS) has a very peculiar bone and soft tissue distribution that maintains height, width, and projection. In RCM, aggressive debridement is prognostic for patient survival. Extensive maxillectomies, often with orbital exenteration represent a reconstructive challenge for plastic surgeons. Recently different types of additive manufacture (AM) technology had been proposed in surgical planning. Fused deposition manufacture (FDM) technology could be the most cost-effective for patients. To the best of our knowledge, this is the first report of the use of FDM and reconstruction of patients with RCM. RCM is a very serious life-threatening condition. When treated in time with the adequate surgical approach and a correct antifungal medicine RCM can be a cured. The goals in treating this condition are very clear. A free flap reconstruction is an adequate approach to patients with RCM and FDM RAM can help the surgeon to plan the free flap in site. We present two cases reconstructed with MSAP and ALT-FL respectively with success assisted with FDM RAM.

Level of Evidence: Level V, therapeutic study.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2BheN1Z

IgE B cells unmasked

(Source: ScienceNOW)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2CbzQos

Application of low-cost fused deposition modeling additive manufacturing rapid anatomic models in patients with rhino-cerebral mucormycosis treated with maxillectomy

Abstract

Mucormycosis is a fungal infection mainly of immunocompromised patients. It has many clinical manifestations depending on the system that is affected. Rhinocerebral mucormycosis and pulmonary infection are the most common. In this pathology, the fungi invade the endothelium of the blood vessels with partial or total obliteration, with tissue ischemia and necrosis. The initial symptoms are unspecific making difficult to identify from other infections and need an expert suspicion level. The gold standard is the culture of the fungi; histopathology analysis shows empty hyphae with thin walls. Combined treatment is strongly recommended surgical extended debridement and Amphotericin B is the gold standard of treatment. The craniofacial skeleton (CS) has a very peculiar bone and soft tissue distribution that maintains height, width, and projection. In RCM, aggressive debridement is prognostic for patient survival. Extensive maxillectomies, often with orbital exenteration represent a reconstructive challenge for plastic surgeons. Recently different types of additive manufacture (AM) technology had been proposed in surgical planning. Fused deposition manufacture (FDM) technology could be the most cost-effective for patients. To the best of our knowledge, this is the first report of the use of FDM and reconstruction of patients with RCM. RCM is a very serious life-threatening condition. When treated in time with the adequate surgical approach and a correct antifungal medicine RCM can be a cured. The goals in treating this condition are very clear. A free flap reconstruction is an adequate approach to patients with RCM and FDM RAM can help the surgeon to plan the free flap in site. We present two cases reconstructed with MSAP and ALT-FL respectively with success assisted with FDM RAM.

Level of Evidence: Level V, therapeutic study.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2BheN1Z

The mysterious rise of meat allergies: Tick bites are driving rates up

It is only in recent years that scientists have identified and acknowledged that tick bites are triggering an allergy to a sugar in the muscles of most animals (but not humans or apes (Source: the Mail online | Health)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Lf19kC

High-affinity allergen-specific human antibodies cloned from single IgE B cell transcriptomes

Immunoglobulin E (IgE) antibodies protect against helminth infections but can also cause life-threatening allergic reactions. Despite their role in human health, the cells that produce these antibodies are rarely observed and remain enigmatic. We isolated single IgE B cells from individuals with food allergies and used single-cell RNA sequencing to elucidate the gene expression and splicing patterns unique to these cells. We identified a surprising example of convergent evolution in which IgE antibodies underwent identical gene rearrangements in unrelated individuals. Through the acquisition of variable region mutations, these IgE antibodies gained high affinity and unexpected cross-reactivity to the clinically important peanut allergens Ara h 2 and Ara h 3. These findings provide insight ...

MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Lk1gLS

Study Finds Almost 4% of Cancers Worldwide Linked to Obesity - BioSpace

Study Finds Almost 4% of Cancers Worldwide Linked to Obesity  BioSpace

A recent study published in CA: A Cancer Journal for Clinicians, a peer-review journal of the American Cancer Society, links excess body weight to ...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2UDCBpP

IgE B cells unmasked

(Source: ScienceNOW)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2CbzQos

The mysterious rise of meat allergies: Tick bites are driving rates up

It is only in recent years that scientists have identified and acknowledged that tick bites are triggering an allergy to a sugar in the muscles of most animals (but not humans or apes (Source: the Mail online | Health)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Lf19kC

High-affinity allergen-specific human antibodies cloned from single IgE B cell transcriptomes

Immunoglobulin E (IgE) antibodies protect against helminth infections but can also cause life-threatening allergic reactions. Despite their role in human health, the cells that produce these antibodies are rarely observed and remain enigmatic. We isolated single IgE B cells from individuals with food allergies and used single-cell RNA sequencing to elucidate the gene expression and splicing patterns unique to these cells. We identified a surprising example of convergent evolution in which IgE antibodies underwent identical gene rearrangements in unrelated individuals. Through the acquisition of variable region mutations, these IgE antibodies gained high affinity and unexpected cross-reactivity to the clinically important peanut allergens Ara h 2 and Ara h 3. These findings provide insight ...

MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Lk1gLS

Study Finds Almost 4% of Cancers Worldwide Linked to Obesity - BioSpace

Study Finds Almost 4% of Cancers Worldwide Linked to Obesity  BioSpace

A recent study published in CA: A Cancer Journal for Clinicians, a peer-review journal of the American Cancer Society, links excess body weight to ...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2UDCBpP

Use of the myocutaneous serratus anterior free flap for reconstruction after salvage glossectomy

Abstract

Purpose

To describe the use of a myocutaneous serratus anterior free flap (SAFF) for tongue reconstruction after salvage subtotal (STG) and total glossectomy (TG).

Methods

In this prospective case series, seven patients underwent salvage STG or TG and reconstruction with a myocutaneous SAFF between 10/2015 and 02/2017. Functional and oncologic outcomes were prospectively evaluated. Donor side morbidity was determined using the Disabilities of the Arm, Shoulder and Hand (DASH) score.

Results

SAFF with mean skin paddles of 6.7 cm × 8.7 cm was used in five STG and two TG patients, respectively. There was a 100% flap survival and a mean DASH score of 10.8 reflected normal arm and shoulder function after surgery. One year after salvage surgery, 1 (14.3%) and 4 (57.1%) patients were tracheostomy and gastrostomy tube dependent. Gastrostomy tube dependence was significantly worse in patients with tumors of the base of tongue compared to other tumor sites (p = 0.030) and in patients who underwent transcervical compared to transoral tumor resection (p = 0.008). Local recurrence rate was 57.1% with a disease-free survival of 17.6 months.

Conclusion

The myocutaneous SAFF represents a safe and reliable flap for tongue reconstruction after salvage glossectomy with satisfying functional outcomes and low donor side morbidity.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2LfJf16

Efficacy of Endo-Ice followed by intrapulpal ice application as an adjunct to inferior alveolar nerve block in patients with symptomatic irreversible pulpitis—a randomized controlled trial

Abstract

Objective

The purpose of the present study was to evaluate the effect of Endo-Ice followed by intrapulpal ice application for reducing pain during pulp extirpation in mandibular molars with symptomatic irreversible pulpitis.

Materials and methods

Sixty patients diagnosed with symptomatic irreversible pulpitis participated in the present study. Subjects were randomly allocated to any one of the following groups: control group—inferior alveolar nerve block with lignocaine (2%) adrenaline (1:80000), articaine group—inferior alveolar nerve block with lignocaine (2%) adrenaline (1:80000) + Buccal infiltration with articaine (4%) with adrenaline (1:100000); or cold group—inferior alveolar nerve block with lignocaine (2%) adrenaline (1:80000) + cold application. The outcome assessor measured the level of pain during access opening and pulp extirpation using the visual analogue scale. The anxiety level of the patient was also measured.

Results

During access opening, there was a significant difference in the pain reduction in the articaine group when compared to cold and control group (p value = 0.02). During pulp extirpation, cold group and articaine group showed a significant reduction in pain levels as compared to the control group (p value = 0.001). There was no difference in the pain level during pulp extirpation among the two test arms (articaine and cold) (p value = 0.99). Further, cold significantly reduced the level of anxiety when compared to the articaine or control group (p value = 0.001).

Conclusion

Hence, cold is a simple, supplementary technique in reducing pain during pulp extirpation.

Clinical relevance

Application of cold may help in minimizing the fear of additional injection in managing pain during endodontic treatment.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2EueMMi

Application of low-cost fused deposition modeling additive manufacturing rapid anatomic models in patients with rhino-cerebral mucormycosis treated with maxillectomy

Abstract

Mucormycosis is a fungal infection mainly of immunocompromised patients. It has many clinical manifestations depending on the system that is affected. Rhinocerebral mucormycosis and pulmonary infection are the most common. In this pathology, the fungi invade the endothelium of the blood vessels with partial or total obliteration, with tissue ischemia and necrosis. The initial symptoms are unspecific making difficult to identify from other infections and need an expert suspicion level. The gold standard is the culture of the fungi; histopathology analysis shows empty hyphae with thin walls. Combined treatment is strongly recommended surgical extended debridement and Amphotericin B is the gold standard of treatment. The craniofacial skeleton (CS) has a very peculiar bone and soft tissue distribution that maintains height, width, and projection. In RCM, aggressive debridement is prognostic for patient survival. Extensive maxillectomies, often with orbital exenteration represent a reconstructive challenge for plastic surgeons. Recently different types of additive manufacture (AM) technology had been proposed in surgical planning. Fused deposition manufacture (FDM) technology could be the most cost-effective for patients. To the best of our knowledge, this is the first report of the use of FDM and reconstruction of patients with RCM. RCM is a very serious life-threatening condition. When treated in time with the adequate surgical approach and a correct antifungal medicine RCM can be a cured. The goals in treating this condition are very clear. A free flap reconstruction is an adequate approach to patients with RCM and FDM RAM can help the surgeon to plan the free flap in site. We present two cases reconstructed with MSAP and ALT-FL respectively with success assisted with FDM RAM.

Level of Evidence: Level V, therapeutic study.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2BheN1Z

Use of the myocutaneous serratus anterior free flap for reconstruction after salvage glossectomy

Abstract

Purpose

To describe the use of a myocutaneous serratus anterior free flap (SAFF) for tongue reconstruction after salvage subtotal (STG) and total glossectomy (TG).

Methods

In this prospective case series, seven patients underwent salvage STG or TG and reconstruction with a myocutaneous SAFF between 10/2015 and 02/2017. Functional and oncologic outcomes were prospectively evaluated. Donor side morbidity was determined using the Disabilities of the Arm, Shoulder and Hand (DASH) score.

Results

SAFF with mean skin paddles of 6.7 cm × 8.7 cm was used in five STG and two TG patients, respectively. There was a 100% flap survival and a mean DASH score of 10.8 reflected normal arm and shoulder function after surgery. One year after salvage surgery, 1 (14.3%) and 4 (57.1%) patients were tracheostomy and gastrostomy tube dependent. Gastrostomy tube dependence was significantly worse in patients with tumors of the base of tongue compared to other tumor sites (p = 0.030) and in patients who underwent transcervical compared to transoral tumor resection (p = 0.008). Local recurrence rate was 57.1% with a disease-free survival of 17.6 months.

Conclusion

The myocutaneous SAFF represents a safe and reliable flap for tongue reconstruction after salvage glossectomy with satisfying functional outcomes and low donor side morbidity.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2LfJf16

Efficacy of Endo-Ice followed by intrapulpal ice application as an adjunct to inferior alveolar nerve block in patients with symptomatic irreversible pulpitis—a randomized controlled trial

Abstract

Objective

The purpose of the present study was to evaluate the effect of Endo-Ice followed by intrapulpal ice application for reducing pain during pulp extirpation in mandibular molars with symptomatic irreversible pulpitis.

Materials and methods

Sixty patients diagnosed with symptomatic irreversible pulpitis participated in the present study. Subjects were randomly allocated to any one of the following groups: control group—inferior alveolar nerve block with lignocaine (2%) adrenaline (1:80000), articaine group—inferior alveolar nerve block with lignocaine (2%) adrenaline (1:80000) + Buccal infiltration with articaine (4%) with adrenaline (1:100000); or cold group—inferior alveolar nerve block with lignocaine (2%) adrenaline (1:80000) + cold application. The outcome assessor measured the level of pain during access opening and pulp extirpation using the visual analogue scale. The anxiety level of the patient was also measured.

Results

During access opening, there was a significant difference in the pain reduction in the articaine group when compared to cold and control group (p value = 0.02). During pulp extirpation, cold group and articaine group showed a significant reduction in pain levels as compared to the control group (p value = 0.001). There was no difference in the pain level during pulp extirpation among the two test arms (articaine and cold) (p value = 0.99). Further, cold significantly reduced the level of anxiety when compared to the articaine or control group (p value = 0.001).

Conclusion

Hence, cold is a simple, supplementary technique in reducing pain during pulp extirpation.

Clinical relevance

Application of cold may help in minimizing the fear of additional injection in managing pain during endodontic treatment.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2EueMMi

Application of low-cost fused deposition modeling additive manufacturing rapid anatomic models in patients with rhino-cerebral mucormycosis treated with maxillectomy

Abstract

Mucormycosis is a fungal infection mainly of immunocompromised patients. It has many clinical manifestations depending on the system that is affected. Rhinocerebral mucormycosis and pulmonary infection are the most common. In this pathology, the fungi invade the endothelium of the blood vessels with partial or total obliteration, with tissue ischemia and necrosis. The initial symptoms are unspecific making difficult to identify from other infections and need an expert suspicion level. The gold standard is the culture of the fungi; histopathology analysis shows empty hyphae with thin walls. Combined treatment is strongly recommended surgical extended debridement and Amphotericin B is the gold standard of treatment. The craniofacial skeleton (CS) has a very peculiar bone and soft tissue distribution that maintains height, width, and projection. In RCM, aggressive debridement is prognostic for patient survival. Extensive maxillectomies, often with orbital exenteration represent a reconstructive challenge for plastic surgeons. Recently different types of additive manufacture (AM) technology had been proposed in surgical planning. Fused deposition manufacture (FDM) technology could be the most cost-effective for patients. To the best of our knowledge, this is the first report of the use of FDM and reconstruction of patients with RCM. RCM is a very serious life-threatening condition. When treated in time with the adequate surgical approach and a correct antifungal medicine RCM can be a cured. The goals in treating this condition are very clear. A free flap reconstruction is an adequate approach to patients with RCM and FDM RAM can help the surgeon to plan the free flap in site. We present two cases reconstructed with MSAP and ALT-FL respectively with success assisted with FDM RAM.

Level of Evidence: Level V, therapeutic study.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2BheN1Z

TMJ arthrosis: does the occlusal relationship really interfere? A comparison between cone beam computed tomography and dried skulls

Abstract

The aim of this study was to investigate the association between condylar bone morphological characteristics with occlusal conditions. Besides the study will compare the tomography images with the real condition in 122 temporomandibular joints from 61 skulls. The occlusal conditions were evaluated by number of teeth missing, measurement of overjet and overbite, in millimeters, and presence or absence of crossbite, openbite and dental rotation. The condylar bone morphological conditions were classified in five types (normal, presence of erosion, presence of osteophytes, flattening and/or deformation). This classification was used in real skulls and in Cone Beam Computed tomography (CBCT) images. The data were submitted to statistical analysis with a level of significance of 0.05. Occlusal variables have no association to morphologic data (p > 0.05). Normal condylar bone was seen in 62 CBCT versus 53 in real skulls while morphological alterations were seen in 60 CBCT versus 67-real condyles. The clinical and tomographic measurements were compared, demonstrating an important difference in the classification demonstrating poor association between detection methods (k − 0.3, p < 0.001). The occlusal conditions appear to have no correlation with the morphological condyle conditions. The CBCT is a reliable diagnostic method, although it may present divergences of findings when compared with clinical raw examination to morphologic condylar conditions.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Ccb5bG

Saint Barnabas is First to Offer Halcyon System for Image-Guided Cancer Treatments - TAPinto.net

Saint Barnabas is First to Offer Halcyon System for Image-Guided Cancer Treatments  TAPinto.net

LIVINGSTON, NJ — Saint Barnabas Medical Center's (SBMC) Department of Radiation Oncology is the first in New Jersey to offer the Halcyon system for ...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2zX1mEK

TMJ arthrosis: does the occlusal relationship really interfere? A comparison between cone beam computed tomography and dried skulls

Abstract

The aim of this study was to investigate the association between condylar bone morphological characteristics with occlusal conditions. Besides the study will compare the tomography images with the real condition in 122 temporomandibular joints from 61 skulls. The occlusal conditions were evaluated by number of teeth missing, measurement of overjet and overbite, in millimeters, and presence or absence of crossbite, openbite and dental rotation. The condylar bone morphological conditions were classified in five types (normal, presence of erosion, presence of osteophytes, flattening and/or deformation). This classification was used in real skulls and in Cone Beam Computed tomography (CBCT) images. The data were submitted to statistical analysis with a level of significance of 0.05. Occlusal variables have no association to morphologic data (p > 0.05). Normal condylar bone was seen in 62 CBCT versus 53 in real skulls while morphological alterations were seen in 60 CBCT versus 67-real condyles. The clinical and tomographic measurements were compared, demonstrating an important difference in the classification demonstrating poor association between detection methods (k − 0.3, p < 0.001). The occlusal conditions appear to have no correlation with the morphological condyle conditions. The CBCT is a reliable diagnostic method, although it may present divergences of findings when compared with clinical raw examination to morphologic condylar conditions.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Ccb5bG

Saint Barnabas is First to Offer Halcyon System for Image-Guided Cancer Treatments - TAPinto.net

Saint Barnabas is First to Offer Halcyon System for Image-Guided Cancer Treatments  TAPinto.net

LIVINGSTON, NJ — Saint Barnabas Medical Center's (SBMC) Department of Radiation Oncology is the first in New Jersey to offer the Halcyon system for ...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2zX1mEK

High-affinity allergen-specific human antibodies cloned from single IgE B cell transcriptomes

Immunoglobulin E (IgE) antibodies protect against helminth infections but can also cause life-threatening allergic reactions. Despite their role in human health, the cells that produce these antibodies are rarely observed and remain enigmatic. We isolated single IgE B cells from individuals with food allergies and used single-cell RNA sequencing to elucidate the gene expression and splicing patterns unique to these cells. We identified a surprising example of convergent evolution in which IgE antibodies underwent identical gene rearrangements in unrelated individuals. Through the acquisition of variable region mutations, these IgE antibodies gained high affinity and unexpected cross-reactivity to the clinically important peanut allergens Ara h 2 and Ara h 3. These findings provide insight ...

MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.

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[ASAP] A Convergent Route to Enantiomers of the Bicyclic Monosaccharide Bradyrhizose Leads to Insight into the Bioactivity of an Immunologically Silent Lipopolysaccharide

The Journal of Organic ChemistryDOI: 10.1021/acs.joc.8b02206 (Source: The Journal of Organic Chemistry)

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Ccn5Km

The mysterious rise of meat allergies: Tick bites are driving rates up

It is only in recent years that scientists have identified and acknowledged that tick bites are triggering an allergy to a sugar in the muscles of most animals (but not humans or apes (Source: the Mail online | Health)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

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IgE B cells unmasked

(Source: ScienceNOW)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2CbzQos

The Inhibitory Role of M2000 ( β-D-Mannuronic Acid) on Expression of Toll-like Receptor 2 and 4 in HT29 Cell Line.

CONCLUSION: Our study which was conducted in colonic epithelial cell model, shows that M2000 can be considered as a new anti-inflammatory agent in IBD. However, more comprehensive experimental and clinical studies are required to recognize the molecular mechanism of M2000 and also its safety and efficacy. PMID: 30539708 [PubMed - as supplied by publisher] (Source: Recent Patents on Inflammation and Allergy Drug Discovery)

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The late Paul Allen leaves $125 million for immunology research center

The third Allen Institute will track the immune systems of healthy people, and those with autoimmune diseases (Source: Chemical and Engineering News)

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The mysterious rise of meat allergies: Tick bites are driving rates up

It is only in recent years that scientists have identified and acknowledged that tick bites are triggering an allergy to a sugar in the muscles of most animals (but not humans or apes (Source: the Mail online | Health)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Lf19kC

IgE B cells unmasked

(Source: ScienceNOW)

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High-affinity allergen-specific human antibodies cloned from single IgE B cell transcriptomes

Immunoglobulin E (IgE) antibodies protect against helminth infections but can also cause life-threatening allergic reactions. Despite their role in human health, the cells that produce these antibodies are rarely observed and remain enigmatic. We isolated single IgE B cells from individuals with food allergies and used single-cell RNA sequencing to elucidate the gene expression and splicing patterns unique to these cells. We identified a surprising example of convergent evolution in which IgE antibodies underwent identical gene rearrangements in unrelated individuals. Through the acquisition of variable region mutations, these IgE antibodies gained high affinity and unexpected cross-reactivity to the clinically important peanut allergens Ara h 2 and Ara h 3. These findings provide insight ...

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The Inhibitory Role of M2000 ( β-D-Mannuronic Acid) on Expression of Toll-like Receptor 2 and 4 in HT29 Cell Line.

CONCLUSION: Our study which was conducted in colonic epithelial cell model, shows that M2000 can be considered as a new anti-inflammatory agent in IBD. However, more comprehensive experimental and clinical studies are required to recognize the molecular mechanism of M2000 and also its safety and efficacy. PMID: 30539708 [PubMed - as supplied by publisher] (Source: Recent Patents on Inflammation and Allergy Drug Discovery)

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The late Paul Allen leaves $125 million for immunology research center

The third Allen Institute will track the immune systems of healthy people, and those with autoimmune diseases (Source: Chemical and Engineering News)

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[ASAP] A Convergent Route to Enantiomers of the Bicyclic Monosaccharide Bradyrhizose Leads to Insight into the Bioactivity of an Immunologically Silent Lipopolysaccharide

The Journal of Organic ChemistryDOI: 10.1021/acs.joc.8b02206 (Source: The Journal of Organic Chemistry)

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Human Papillomaviru Therapeutics Market Analysis, Drivers, Restraints, Opportunities, Threats, Trends, Applications, And Growth Forecast To 2025 - thestocknewsnow.com

Human Papillomaviru Therapeutics Market Analysis, Drivers, Restraints, Opportunities, Threats, Trends, Applications, And Growth Forecast To 2025  thestocknewsnow.com

QYResearch is a leading market research publisher which pursuits high product quality with the belief that quality is the soul of business and consulting group ...

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Human Papillomaviru Therapeutics Market Analysis, Drivers, Restraints, Opportunities, Threats, Trends, Applications, And Growth Forecast To 2025 - thestocknewsnow.com

Human Papillomaviru Therapeutics Market Analysis, Drivers, Restraints, Opportunities, Threats, Trends, Applications, And Growth Forecast To 2025  thestocknewsnow.com

QYResearch is a leading market research publisher which pursuits high product quality with the belief that quality is the soul of business and consulting group ...

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Photophysics of Perylene Monoimide-labelled Organocatalysts

Photochem. Photobiol. Sci., 2018, Accepted Manuscript
DOI: 10.1039/C8PP00462E, Paper

Albert Manfred Brouwer, Dongdong Zheng, Mina Raeisolsadati Oskouei, Hans J. Sanders, Junhong Qian, René M. Williams
We designed and synthesized cinchona alkaloid derivates PMI-BnCPD, 1 and PMI-dHQD, 2, in which a fluorescent perylene monoimide unit is linked to the quinuclidine fragment. The latter acts as an...
The content of this RSS Feed (c) The Royal Society of Chemistry

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UV-A screening in Cladophora sp. lowers internal UV-A availability and photoreactivation as compared to non-UV screening Ulva intestinalis

Photochem. Photobiol. Sci., 2018, Accepted Manuscript
DOI: 10.1039/C8PP00432C, Paper

Frauke Pescheck
In the Baltic Sea, the two co-occurring green macroalgae Cladophora sp. and Ulva intestinalis grow in the upper eulittoral. Due to regular and high sunlight exposure in their habitat, both...
The content of this RSS Feed (c) The Royal Society of Chemistry

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A theoretical study of 5,6,7,8-tetrahydro-6-hydroxymethylpterin: insight into intrinsic photoreceptor properties of 6-substituted tetrahydropterins

Photochem. Photobiol. Sci., 2019, Advance Article
DOI: 10.1039/C8PP00322J, Paper

A. A. Buglak, T. A. Telegina
For the first time, we demonstrated that the nature of the excited states of H₄pterins is similar to the nature of the excited states of guanine.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

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Photophysics of Perylene Monoimide-labelled Organocatalysts

Photochem. Photobiol. Sci., 2018, Accepted Manuscript
DOI: 10.1039/C8PP00462E, Paper

Albert Manfred Brouwer, Dongdong Zheng, Mina Raeisolsadati Oskouei, Hans J. Sanders, Junhong Qian, René M. Williams
We designed and synthesized cinchona alkaloid derivates PMI-BnCPD, 1 and PMI-dHQD, 2, in which a fluorescent perylene monoimide unit is linked to the quinuclidine fragment. The latter acts as an...
The content of this RSS Feed (c) The Royal Society of Chemistry

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Laser flash photolysis study of the photoinduced oxidation of 4-(dimethylamino)benzonitrile (DMABN)

Photochem. Photobiol. Sci., 2018, Accepted Manuscript
DOI: 10.1039/C8PP00519B, Paper

Frank Leresche, Lucie Ludvikova, Dominik Heger, Petr Klán, Urs von Gunten, Silvio Canonica
Aromatic amines are aquatic contaminants for which phototransformation in surface waters can be induced by excited triplet states of dissolved organic matter (³DOM*). The first reaction step is assumed to...
The content of this RSS Feed (c) The Royal Society of Chemistry

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UV-A screening in Cladophora sp. lowers internal UV-A availability and photoreactivation as compared to non-UV screening Ulva intestinalis

Photochem. Photobiol. Sci., 2018, Accepted Manuscript
DOI: 10.1039/C8PP00432C, Paper

Frauke Pescheck
In the Baltic Sea, the two co-occurring green macroalgae Cladophora sp. and Ulva intestinalis grow in the upper eulittoral. Due to regular and high sunlight exposure in their habitat, both...
The content of this RSS Feed (c) The Royal Society of Chemistry

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A theoretical study of 5,6,7,8-tetrahydro-6-hydroxymethylpterin: insight into intrinsic photoreceptor properties of 6-substituted tetrahydropterins

Photochem. Photobiol. Sci., 2019, Advance Article
DOI: 10.1039/C8PP00322J, Paper

A. A. Buglak, T. A. Telegina
For the first time, we demonstrated that the nature of the excited states of H₄pterins is similar to the nature of the excited states of guanine.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

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Europe Head & Neck Cancer Market and Competitive Landscape - 2018 - ResearchAndMarkets.com - News Press Release - PharmiWeb.com

Europe Head & Neck Cancer Market and Competitive Landscape - 2018 - ResearchAndMarkets.com - News Press Release  PharmiWeb.com

More Research and Markets press releases. The "Europe Head & Neck Cancer Market and Competitive Landscape - 2018" report has been added to ...

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A tiny patch with the potential to beat cancer - KATU

A tiny patch with the potential to beat cancer  KATU

CINCINNATI (WKRC) - Local doctors are among the first in the country to test a potential new therapy to fight cancer that could change outcomes in ways never ...

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Europe Head & Neck Cancer Market and Competitive Landscape - 2018 - ResearchAndMarkets.com - News Press Release - PharmiWeb.com

Europe Head & Neck Cancer Market and Competitive Landscape - 2018 - ResearchAndMarkets.com - News Press Release  PharmiWeb.com

More Research and Markets press releases. The "Europe Head & Neck Cancer Market and Competitive Landscape - 2018" report has been added to ...

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A tiny patch with the potential to beat cancer - KATU

A tiny patch with the potential to beat cancer  KATU

CINCINNATI (WKRC) - Local doctors are among the first in the country to test a potential new therapy to fight cancer that could change outcomes in ways never ...

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Brain {beta}-Amyloid and Atrophy in Individuals at Increased Risk of Cognitive Decline [ADULT BRAIN]

BACKGROUND AND PURPOSE:

The relationship between brain β-amyloid and regional atrophy is still incompletely understood in elderly individuals at risk of dementia. Here, we studied the associations between brain β-amyloid load and regional GM and WM volumes in older adults who were clinically evaluated as being at increased risk of cognitive decline based on cardiovascular risk factors.

MATERIALS AND METHODS:

Forty subjects (63–81 years of age) were recruited as part of a larger study, the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability. Neuroimaging consisted of PET using ¹¹C Pittsburgh compound-B and T1-weighted 3D MR imaging for the measurement of brain β-amyloid and GM and WM volumes, respectively. All subjects underwent clinical, genetic, and neuropsychological evaluations for the assessment of cognitive function and the identification of cardiovascular risk factors.

RESULTS:

Sixteen subjects were visually evaluated as showing cortical β-amyloid (positive for β-amyloid). In the voxel-by-voxel analyses, no significant differences were found in GM and WM volumes between the samples positive and negative for β-amyloid. However, in the sample positive for β-amyloid, increases in ¹¹C Pittsburgh compound-B uptake were associated with reductions in GM volume in the left prefrontal (P = .02) and right temporal lobes (P = .04).

CONCLUSIONS:

Our results show a significant association between increases in brain β-amyloid and reductions in regional GM volume in individuals at increased risk of cognitive decline. This evidence is consistent with a model in which increases in β-amyloid incite neurodegeneration in memory systems before cognitive impairment manifests.

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MRI Abnormalities Predominate in the Bottom Part of the Sulcus with Type II Focal Cortical Dysplasia: A Quantitative Study [PEDIATRICS]

BACKGROUND AND PURPOSE:

Type II focal cortical dysplasia is a common histopathological substrate in focal epilepsy. This study explored the spatial distribution of abnormal findings on MR imaging across the sulcus with type II focal cortical dysplasia using quantitative MR imaging postprocessing techniques.

MATERIALS AND METHODS:

The morphometric analysis program and normalized FLAIR signal intensity analysis were applied to retrospectively analyze the MR imaging data of 58 patients with histopathologically confirmed type II focal cortical dysplasia. We divided the dysplastic sulcus into the bottom and nonbottom parts. Then spatial distribution types 1, 2, and 3 were arbitrarily defined as the abnormal findings on MR imaging (z-value > threshold) located in the bottom part, both the bottom and nonbottom parts, and the nonbottom part, respectively. For type 2, the mean z-values and standardized volumes of abnormal findings on MR imaging were compared between the bottom and nonbottom parts.

RESULTS:

Abnormal findings on MR imaging were detected by quantitative techniques in 42 of 58 enrolled patients. Among these 42 patients, 38 and 26 patients showed gray-white matter junction blurring and cortical FLAIR hyperintensity, respectively, which were the 2 most common abnormal MR imaging features. Gray-white matter junction blurring manifested as types 1, 2, and 3 in 24, 13, and 1 patient, respectively, and the corresponding counts for cortical FLAIR hyperintensity were 12, 13, and 1 patient. For the 2 most common abnormal findings on MR imaging spatially manifested as type 2, higher mean z-values and larger corresponding standardized volumes of abnormalities were found in the bottom part.

CONCLUSIONS:

Abnormal findings on MR imaging predominate in the bottom part of the sulcus with type II focal cortical dysplasia, which indicates that this malformation is bottom-of-sulcus-rooted.

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Defining the Normal Dorsal Contour of the Corpus Callosum with Time [ADULT BRAIN]

BACKGROUND AND PURPOSE:

Morphological changes of the corpus callosum have been associated with a large number of congenital neurocognitive and psychiatric disorders. Focal defects or notches of the dorsal surface of the corpus callosum have not been well characterized. Our purpose was the following; 1) to characterize the dorsal contour of the corpus callosum during the life span, 2) to characterize the relationship of contour deviations to neighboring vessels, and 3) to determine whether contour deviations are congenital or acquired.

MATERIALS AND METHODS:

We retrospectively reviewed normal sagittal T1-weighted brain MR images. A "notch" was defined as a concavity in the dorsal surface at least 1 mm in depth. The corpus callosum was considered to be "undulating" if there were >2 notches, including an anterior and posterior notch. The presence of a pericallosal artery and its relationship to a notch were assessed.

RESULTS:

We reviewed 1639 MR imaging studies, spanning 0–89 years of age. A total of 1102 notches were identified in 823 studies; 344 (31%) were anterior, 660 (60%) were posterior, and 98 (9%), undulating. There was a positive correlation between the prevalence (P < .001) and depth (P = .028) of an anterior notch and age and a negative correlation between the prevalence of a posterior notch and age (P < .001). There was no difference between patient sex and corpus callosum notching (P = .884). Of the 823 studies with notches, 490 (60%) were associated with a pericallosal artery (P < .001).

CONCLUSIONS:

The prevalence and depth of notches in the anterior corpus callosum increase significantly with age; this finding suggests that most notches are acquired. There is a significant positive association between the presence of a corpus callosum notch and adjacent pericallosal arteries, suggesting that this may play a role in notch formation.

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MRI Abnormalities Predominate in the Bottom Part of the Sulcus with Type II Focal Cortical Dysplasia: A Quantitative Study [PEDIATRICS]

BACKGROUND AND PURPOSE:

Type II focal cortical dysplasia is a common histopathological substrate in focal epilepsy. This study explored the spatial distribution of abnormal findings on MR imaging across the sulcus with type II focal cortical dysplasia using quantitative MR imaging postprocessing techniques.

MATERIALS AND METHODS:

The morphometric analysis program and normalized FLAIR signal intensity analysis were applied to retrospectively analyze the MR imaging data of 58 patients with histopathologically confirmed type II focal cortical dysplasia. We divided the dysplastic sulcus into the bottom and nonbottom parts. Then spatial distribution types 1, 2, and 3 were arbitrarily defined as the abnormal findings on MR imaging (z-value > threshold) located in the bottom part, both the bottom and nonbottom parts, and the nonbottom part, respectively. For type 2, the mean z-values and standardized volumes of abnormal findings on MR imaging were compared between the bottom and nonbottom parts.

RESULTS:

Abnormal findings on MR imaging were detected by quantitative techniques in 42 of 58 enrolled patients. Among these 42 patients, 38 and 26 patients showed gray-white matter junction blurring and cortical FLAIR hyperintensity, respectively, which were the 2 most common abnormal MR imaging features. Gray-white matter junction blurring manifested as types 1, 2, and 3 in 24, 13, and 1 patient, respectively, and the corresponding counts for cortical FLAIR hyperintensity were 12, 13, and 1 patient. For the 2 most common abnormal findings on MR imaging spatially manifested as type 2, higher mean z-values and larger corresponding standardized volumes of abnormalities were found in the bottom part.

CONCLUSIONS:

Abnormal findings on MR imaging predominate in the bottom part of the sulcus with type II focal cortical dysplasia, which indicates that this malformation is bottom-of-sulcus-rooted.

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Early Diagnosis of Spastic Cerebral Palsy in Infants with Periventricular White Matter Injury Using Diffusion Tensor Imaging [FUNCTIONAL]

BACKGROUND AND PURPOSE:

Periventricular white matter injury is the common cause of spastic cerebral palsy. However, the early diagnosis of spastic cerebral palsy still remains a challenge. Our aim was to investigate whether infants with periventricular white matter injury with bilateral spastic cerebral palsy have unique lesions different from those in infants without cerebral palsy and to evaluate the efficiency of DTI in the early diagnosis of spastic cerebral palsy.

MATERIALS AND METHODS:

Infants with periventricular white matter injury and controls underwent MR imaging at 6–18 months of age. Fractional anisotropy was calculated from DTI. Cerebral palsy was diagnosed by 24–30 months of age. Subjects were divided into 3 groups: infants with periventricular white matter injury with bilateral spastic cerebral palsy, infants with periventricular white matter injury without cerebral palsy, and controls. Tract-Based Spatial Statistics and Automated Fiber Quantification were used to investigate intergroup differences. Receiver operating characteristic curves were used to assess the diagnostic accuracy of spastic cerebral palsy. Correlations between motor function scores and fractional anisotropy were evaluated along white matter tracts.

RESULTS:

There were 20, 19, and 33 subjects in periventricular white matter injury with spastic cerebral palsy, periventricular white matter injury without cerebral palsy, and control groups, respectively. Decreased fractional anisotropy in the corticospinal tract was only observed in infants with periventricular white matter injury with spastic cerebral palsy, whereas decreased fractional anisotropy in the posterior thalamic radiation and genu and splenium of the corpus callosum was seen in both periventricular white matter injury subgroups. Fractional anisotropy in the corticospinal tract at the internal capsule level was effective in differentiating infants with periventricular white matter injury with spastic cerebral palsy from those without cerebral palsy by a threshold of 0.53, and it had strong correlations with motor function scores.

CONCLUSIONS:

Corticospinal tract lesions play a crucial role in motor impairment related to spastic cerebral palsy in infants with periventricular white matter injury. Fractional anisotropy in the corticospinal tract at the internal capsule level could aid in the early diagnosis of spastic cerebral palsy with high diagnostic accuracy.

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Defining the Normal Dorsal Contour of the Corpus Callosum with Time [ADULT BRAIN]

BACKGROUND AND PURPOSE:

Morphological changes of the corpus callosum have been associated with a large number of congenital neurocognitive and psychiatric disorders. Focal defects or notches of the dorsal surface of the corpus callosum have not been well characterized. Our purpose was the following; 1) to characterize the dorsal contour of the corpus callosum during the life span, 2) to characterize the relationship of contour deviations to neighboring vessels, and 3) to determine whether contour deviations are congenital or acquired.

MATERIALS AND METHODS:

We retrospectively reviewed normal sagittal T1-weighted brain MR images. A "notch" was defined as a concavity in the dorsal surface at least 1 mm in depth. The corpus callosum was considered to be "undulating" if there were >2 notches, including an anterior and posterior notch. The presence of a pericallosal artery and its relationship to a notch were assessed.

RESULTS:

We reviewed 1639 MR imaging studies, spanning 0–89 years of age. A total of 1102 notches were identified in 823 studies; 344 (31%) were anterior, 660 (60%) were posterior, and 98 (9%), undulating. There was a positive correlation between the prevalence (P < .001) and depth (P = .028) of an anterior notch and age and a negative correlation between the prevalence of a posterior notch and age (P < .001). There was no difference between patient sex and corpus callosum notching (P = .884). Of the 823 studies with notches, 490 (60%) were associated with a pericallosal artery (P < .001).

CONCLUSIONS:

The prevalence and depth of notches in the anterior corpus callosum increase significantly with age; this finding suggests that most notches are acquired. There is a significant positive association between the presence of a corpus callosum notch and adjacent pericallosal arteries, suggesting that this may play a role in notch formation.

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Clinical Feasibility of Zero TE Skull MRI in Patients with Head Trauma in Comparison with CT: A Single-Center Study [ADULT BRAIN]

BACKGROUND AND PURPOSE:

Conventional MR imaging techniques cannot produce optimal images of bone structures because bone has little water and a very short T2 life span. The aim of this study was to investigate the clinical feasibility of skull MR imaging using the zero TE sequence in patients with head trauma by assessing its diagnostic image quality and quantitative measurement compared with CT images.

MATERIALS AND METHODS:

Thirteen enrolled patients with head trauma were assessed using brain CT and skull MR imaging. Image quality was graded on a 5-point Likert scale to compare the 2 modalities. To evaluate quantitative analyses between the 2 imaging modalities, we measured skull thickness and normalized bone tissue signal. Interobserver reliability was assessed using weighted statistics and the intraclass correlation coefficient.

RESULTS:

Both imaging techniques clearly depicted skull fractures in all 13 patients. The mean scores for skull MR imaging and CT were 4.65 ± 0.56 and 4.73 ± 0.45 (P = .157), respectively, with substantial interobserver agreement (P < .05). The 2 imaging modalities showed no difference in skull thickness (P = .092) and had good correlation (r² = 0.997). The mean value of normalized bone tissue signal among the 3 layers of the skull was relatively consistent (P = .401) with high interobserver agreement (P < .001).

CONCLUSIONS:

Zero TE skull MR imaging has diagnostic image quality comparable with that of CT images. It also provides consistent results on the quantitative measurement of cortical bone with CT images.

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Brain {beta}-Amyloid and Atrophy in Individuals at Increased Risk of Cognitive Decline [ADULT BRAIN]

BACKGROUND AND PURPOSE:

The relationship between brain β-amyloid and regional atrophy is still incompletely understood in elderly individuals at risk of dementia. Here, we studied the associations between brain β-amyloid load and regional GM and WM volumes in older adults who were clinically evaluated as being at increased risk of cognitive decline based on cardiovascular risk factors.

MATERIALS AND METHODS:

Forty subjects (63–81 years of age) were recruited as part of a larger study, the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability. Neuroimaging consisted of PET using ¹¹C Pittsburgh compound-B and T1-weighted 3D MR imaging for the measurement of brain β-amyloid and GM and WM volumes, respectively. All subjects underwent clinical, genetic, and neuropsychological evaluations for the assessment of cognitive function and the identification of cardiovascular risk factors.

RESULTS:

Sixteen subjects were visually evaluated as showing cortical β-amyloid (positive for β-amyloid). In the voxel-by-voxel analyses, no significant differences were found in GM and WM volumes between the samples positive and negative for β-amyloid. However, in the sample positive for β-amyloid, increases in ¹¹C Pittsburgh compound-B uptake were associated with reductions in GM volume in the left prefrontal (P = .02) and right temporal lobes (P = .04).

CONCLUSIONS:

Our results show a significant association between increases in brain β-amyloid and reductions in regional GM volume in individuals at increased risk of cognitive decline. This evidence is consistent with a model in which increases in β-amyloid incite neurodegeneration in memory systems before cognitive impairment manifests.

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Man's cancer linked to 2011 N-disaster - The Japan News

Man's cancer linked to 2011 N-disaster  The Japan News

TOKYO (Jiji Press) — The labor ministry said Wednesday that it has recognized as a work-related disease thyroid cancer of a male worker who was exposed to ...

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Study finds toxic substances in all 12 carpets tested - WDIV ClickOnDetroit

Study finds toxic substances in all 12 carpets tested  WDIV ClickOnDetroit

DETROIT - A new study revealed carpets can be dangerous due to toxic substances. The study found 44 toxic substances in all 12 of the carpets tested.

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Study finds toxic substances in all 12 carpets tested - WDIV ClickOnDetroit

Study finds toxic substances in all 12 carpets tested  WDIV ClickOnDetroit

DETROIT - A new study revealed carpets can be dangerous due to toxic substances. The study found 44 toxic substances in all 12 of the carpets tested.

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Quantifying the Benefits of Precision Oncology - Targeted Oncology

Quantifying the Benefits of Precision Oncology  Targeted Oncology

Precision medicine has produced some dramatic successes in patients with advanced cancer. With developments in molecular profiling, targeted therapies are ...

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Man's cancer linked to 2011 N-disaster - The Japan News

Man's cancer linked to 2011 N-disaster  The Japan News

TOKYO (Jiji Press) — The labor ministry said Wednesday that it has recognized as a work-related disease thyroid cancer of a male worker who was exposed to ...

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Ultrasound shear wave elastography effectively predicts integrity of ventral hernia repair using acellular dermal matrix augmented with platelet-rich plasma (PRP)

ConclusionThis study confirms both the efficacy of PRP in augmenting VHR using pADM, as well as the reliability of US-SWE to non-invasively predict the quality of VHR. Although further human studies are necessary, this work supports PRP use to improve VHR outcomes and US-SWE potential for bedside non-invasive hernia characterization. (Source: Surgical Endoscopy)

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CD4+ T cells induce productions of IL-5 and IL-13 through MHCII on ILC2s in a murine model of allergic rhinitis

CD4+ T cells play an important role not only in the induction of allergy but also in allergic inflammation. Group 2 innate lymphoid cells (ILC2s) also mediate type 2 immune responses in allergic rhinitis (AR). However, the relationships between CD4+ T cells and ILC2s in allergic condition are currently not well defined. The study aimed to evaluate the potential influences of CD4+ T cells on ILC2s in the murine model of AR. (Source: Auris, Nasus, Larynx)

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Ultrasound shear wave elastography effectively predicts integrity of ventral hernia repair using acellular dermal matrix augmented with platelet-rich plasma (PRP)

ConclusionThis study confirms both the efficacy of PRP in augmenting VHR using pADM, as well as the reliability of US-SWE to non-invasively predict the quality of VHR. Although further human studies are necessary, this work supports PRP use to improve VHR outcomes and US-SWE potential for bedside non-invasive hernia characterization. (Source: Surgical Endoscopy)

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Nonceliac Wheat Sensitivity

Non-celiac wheat sensitivity (NCWS) is characterized by gastrointestinal and extra-intestinal symptoms following the ingestion of gluten-containing cereals in subjects without celiac disease or wheat allergy. The identity of the molecular triggers in these cereals responsible for the symptoms of NCWS remains to be delineated. Recent research has identified a biological basis for the condition, with the observation of systemic immune activation in response to microbial translocation that appears to be linked to intestinal barrier defects. Ongoing research efforts are aimed at further characterizing the etiology, mechanism, and biomarkers of the condition. (Source: Gastroenterology Clinics of North America)

MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.

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CD4+ T cells induce productions of IL-5 and IL-13 through MHCII on ILC2s in a murine model of allergic rhinitis

CD4+ T cells play an important role not only in the induction of allergy but also in allergic inflammation. Group 2 innate lymphoid cells (ILC2s) also mediate type 2 immune responses in allergic rhinitis (AR). However, the relationships between CD4+ T cells and ILC2s in allergic condition are currently not well defined. The study aimed to evaluate the potential influences of CD4+ T cells on ILC2s in the murine model of AR. (Source: Auris, Nasus, Larynx)

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Cemiplimab Combo Does Not Show Superior ORR to Anti-PD-1 Monotherapy in Advanced HNSCC - Targeted Oncology

Cemiplimab Combo Does Not Show Superior ORR to Anti-PD-1 Monotherapy in Advanced HNSCC  Targeted Oncology

The PD-1 inhibitor cemiplimab in combination with radiotherapy, cyclophosphamide, and granulocyte-macrophage colony-stimulating factor did not demonstrate ...

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Otolaryngology Conference: Technology, Innovation, and Personalized Care in Head and Neck Cancer 2018 - San Francisco November 30 - December 1, 2018 - MD Linx

Otolaryngology Conference: Technology, Innovation, and Personalized Care in Head and Neck Cancer 2018 - San Francisco November 30 - December 1, 2018  MD Linx

This two-day course will provide a comprehensive update on new technologies and clinical advances in head and neck cancer treatment and head and neck ...

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Cemiplimab Combo Does Not Show Superior ORR to Anti-PD-1 Monotherapy in Advanced HNSCC - Targeted Oncology

Cemiplimab Combo Does Not Show Superior ORR to Anti-PD-1 Monotherapy in Advanced HNSCC  Targeted Oncology

The PD-1 inhibitor cemiplimab in combination with radiotherapy, cyclophosphamide, and granulocyte-macrophage colony-stimulating factor did not demonstrate ...

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Spurt in new throat cancer cases in city - The Hans India

Spurt in new throat cancer cases in city  The Hans India

Around 1200 throat cancer patients are added to the list of cancer patients every year in the city Overall about 12 of all cancers in India are related to the throat, ...

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Otolaryngology Conference: Technology, Innovation, and Personalized Care in Head and Neck Cancer 2018 - San Francisco November 30 - December 1, 2018 - MD Linx

Otolaryngology Conference: Technology, Innovation, and Personalized Care in Head and Neck Cancer 2018 - San Francisco November 30 - December 1, 2018  MD Linx

This two-day course will provide a comprehensive update on new technologies and clinical advances in head and neck cancer treatment and head and neck ...

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Inspire's Health Profiles Identifies the Insights of Patients to Unlock Research Gaps - GlobeNewswire

Inspire's Health Profiles Identifies the Insights of Patients to Unlock Research Gaps  GlobeNewswire

Company invites new global academic collaborations to accelerate clinical research.

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Huawei exec. details health problems in affidavit submitted to B.C. court - Toronto Star

Huawei exec. details health problems in affidavit submitted to B.C. court  Toronto Star

Meng Wanzhou says she has suffered a lifetime of health problems, including thyroid cancer, sleep apnea and high blood pressure, but she is ready to fight ...

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Study finds toxic substances in all 12 carpets tested - WDIV ClickOnDetroit

Study finds toxic substances in all 12 carpets tested  WDIV ClickOnDetroit

DETROIT - A new study revealed carpets can be dangerous due to toxic substances. The study found 44 toxic substances in all 12 of the carpets tested.

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Study finds toxic substances in all 12 carpets tested - WDIV ClickOnDetroit

Study finds toxic substances in all 12 carpets tested  WDIV ClickOnDetroit

DETROIT - A new study revealed carpets can be dangerous due to toxic substances. The study found 44 toxic substances in all 12 of the carpets tested.

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Huawei exec. details health problems in affidavit submitted to B.C. court - Toronto Star

Huawei exec. details health problems in affidavit submitted to B.C. court  Toronto Star

Meng Wanzhou says she has suffered a lifetime of health problems, including thyroid cancer, sleep apnea and high blood pressure, but she is ready to fight ...

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Inspire's Health Profiles Identifies the Insights of Patients to Unlock Research Gaps - GlobeNewswire

Inspire's Health Profiles Identifies the Insights of Patients to Unlock Research Gaps  GlobeNewswire

Company invites new global academic collaborations to accelerate clinical research.

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Obesity at fault for 4 percent cancers worldwide, study says - UPI.com

Obesity at fault for 4 percent cancers worldwide, study says  UPI.com

Overweight and obesity accounted for nearly 4 percent of all cancers globally in 2012, and that rate is likely to rise in coming decades, a new study suggests.

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Exercise Significantly Cuts the Risk of Death from Cancer, Roswell Park Study Shows - PR Web

Exercise Significantly Cuts the Risk of Death from Cancer, Roswell Park Study Shows  PR Web

BUFFALO, N.Y. (PRWEB) December 13, 2018 -- New research out of Roswell Park Comprehensive Cancer Center shows that cancer patients who exercise ...

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AstraZeneca mines for positives in Imfinzi's failed Mystic lung cancer trial - FiercePharma

AstraZeneca mines for positives in Imfinzi's failed Mystic lung cancer trial  FiercePharma

AstraZeneca felt the blow last month when Mystic, a key trial examining its immuno-oncology drug Imfinzi in previously untreated lung cancer, failed. But now ...

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Spurt in new throat cancer cases in city - The Hans India

Spurt in new throat cancer cases in city  The Hans India

Around 1200 throat cancer patients are added to the list of cancer patients every year in the city Overall about 12 of all cancers in India are related to the throat, ...

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AstraZeneca mines for positives in Imfinzi's failed Mystic lung cancer trial - FiercePharma

AstraZeneca mines for positives in Imfinzi's failed Mystic lung cancer trial  FiercePharma

AstraZeneca felt the blow last month when Mystic, a key trial examining its immuno-oncology drug Imfinzi in previously untreated lung cancer, failed. But now ...

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Exercise Significantly Cuts the Risk of Death from Cancer, Roswell Park Study Shows - PR Web

Exercise Significantly Cuts the Risk of Death from Cancer, Roswell Park Study Shows  PR Web

BUFFALO, N.Y. (PRWEB) December 13, 2018 -- New research out of Roswell Park Comprehensive Cancer Center shows that cancer patients who exercise ...

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Spurt in new throat cancer cases in city - The Hans India

Spurt in new throat cancer cases in city  The Hans India

Around 1200 throat cancer patients are added to the list of cancer patients every year in the city Overall about 12 of all cancers in India are related to the throat, ...

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Changing face of orofacial pain: The diagnostic impact of working with Neurology on an orofacial pain clinic

This study assessed the impact of collaborative working with a headache neurologist on diagnoses of patients attending orofacial pain (OFP) clinic. Patient diagnostic data was collected from adult patients attending an Orofacial Pain Service from January 2013 to January 2017. A liaison headache neurologist was appointed late 2015; OFP clinics were co-run with the neurologist specialist thereafter. Overall, 639 patients attended the service; 315 in 2013 –2015 and 324 in 2016–2017. Compared to 2013–2015, there were increased rates of diagnoses related to neurovascular (27.5% vs. (Source: International Journal of Oral and Maxillofacial Surgery)

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Follicular Thyroid Cancer Drug Market Major Players Competitive Landscape – AstraZeneca PLC, Exelixis, Inc., GlaxoSmithKline plc - Chesco DOES

Follicular Thyroid Cancer Drug Market Major Players Competitive Landscape – AstraZeneca PLC, Exelixis, Inc., GlaxoSmithKline plc  Chesco DOES

The Global Market for Follicular Thyroid Cancer Drug to 2023 offers detailed coverage of Follicular Thyroid Cancer Drug industry and presents main market ...

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Exercise Significantly Cuts the Risk of Death from Cancer, Roswell Park Study Shows - PR Web

Exercise Significantly Cuts the Risk of Death from Cancer, Roswell Park Study Shows  PR Web

BUFFALO, N.Y. (PRWEB) December 13, 2018 -- New research out of Roswell Park Comprehensive Cancer Center shows that cancer patients who exercise ...

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Medication Errors Resulting in Death Most Common in Elderly

Most common medication error category was omitted medicine or ingredient (Source: The Doctors Lounge - Psychiatry)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

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Mayo Clinic Minute: Holiday allergy triggers

For a person with?allergies, the holiday season can create challenges. Decorated trees,? roaring fires and a plate of Christmas cookies can lead to problems. ?A person who is allergic needs to be an advocate for himself, because it?s always better to be safe than sorry,??says Dr. Rohit Divekar, a Mayo Clinic allergic diseases specialist. You [...] (Source: News from Mayo Clinic)

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Follicular Thyroid Cancer Drug Market Major Players Competitive Landscape – AstraZeneca PLC, Exelixis, Inc., GlaxoSmithKline plc - Chesco DOES

Follicular Thyroid Cancer Drug Market Major Players Competitive Landscape – AstraZeneca PLC, Exelixis, Inc., GlaxoSmithKline plc  Chesco DOES

The Global Market for Follicular Thyroid Cancer Drug to 2023 offers detailed coverage of Follicular Thyroid Cancer Drug industry and presents main market ...

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NOTHING BUT THE TOOTH: Oral cancer screenings should be routine - Wicked Local North of Boston

NOTHING BUT THE TOOTH: Oral cancer screenings should be routine  Wicked Local North of Boston

Q. My simple request is that you please educate readers through your column about the OralID tool and test and the importance of asking for it once a year since ...

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Exercise Significantly Cuts the Risk of Death from Cancer, Roswell Park Study Shows - PR Web

Exercise Significantly Cuts the Risk of Death from Cancer, Roswell Park Study Shows  PR Web

BUFFALO, N.Y. (PRWEB) December 13, 2018 -- New research out of Roswell Park Comprehensive Cancer Center shows that cancer patients who exercise ...

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Medication Errors Resulting in Death Most Common in Elderly

Most common medication error category was omitted medicine or ingredient (Source: The Doctors Lounge - Psychiatry)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

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Mayo Clinic Minute: Holiday allergy triggers

For a person with?allergies, the holiday season can create challenges. Decorated trees,? roaring fires and a plate of Christmas cookies can lead to problems. ?A person who is allergic needs to be an advocate for himself, because it?s always better to be safe than sorry,??says Dr. Rohit Divekar, a Mayo Clinic allergic diseases specialist. You [...] (Source: News from Mayo Clinic)

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Clinical Response to Subcutaneous < b > < i > Dermatophagoides pteronyssinus < /i > < /b > Immunotherapy in Children with Allergic Rhinitis and Asthma Is Independent of Sensitization to < b > < i > Blomia tropicalis < /i > < /b > Allergens

Conclusion: DP-SCIT may be of clinical benefit to patients with IgE sensitizations to both DP and BT. DP-SCIT induces IgG4 that cross-react with BT allergens.Int Arch Allergy Immunol (Source: International Archives of Allergy and Immunology)

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Expression Density of Receptors as a Potent Regulator of Cell Function and Property in Health and Pathology

The expression of cytokine receptors has a crucial role in many cellular processes. Recent studies reported that changes of receptor expression could control the action of mediators on target cells. The initiation of different signaling pathways and, therefore, specific effects on cells, depends on certain components forming the cytokine-receptor complex. These mechanisms control the immune response and affect both the course of diseases (oncological, autoimmune, inflammatory) and the effectiveness of therapy. This review describes the potential of immune mediator receptors to regulate the efficiency of cytokine activity during pathologic processes and ensure the variability of their biological effects. Our aim was to investigate the spectrum of potential roles of changes in mediator recep...

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Characterization of Patients with Ibuprofen Hypersensitivity

Conclusion: In our cohort of patients, ibuprofen hypersensitivity affected females more commonly than males, and presented with mainly cutaneous manifestations. Onset of symptoms was rapid (#x3c; 60 min). Reactions typically ranged in severity from mild to moderate although there was a risk of severe anaphylaxis. There was potential cross-reactivity with other NSAIDs or acetaminophen. The results of our study contribute to the understanding of the demographics and clinical course of ibuprofen hypersensitivity reactions.Int Arch Allergy Immunol (Source: International Archives of Allergy and Immunology)

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Clinical Response to Subcutaneous < b > < i > Dermatophagoides pteronyssinus < /i > < /b > Immunotherapy in Children with Allergic Rhinitis and Asthma Is Independent of Sensitization to < b > < i > Blomia tropicalis < /i > < /b > Allergens

Conclusion: DP-SCIT may be of clinical benefit to patients with IgE sensitizations to both DP and BT. DP-SCIT induces IgG4 that cross-react with BT allergens.Int Arch Allergy Immunol (Source: International Archives of Allergy and Immunology)

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Expression Density of Receptors as a Potent Regulator of Cell Function and Property in Health and Pathology

The expression of cytokine receptors has a crucial role in many cellular processes. Recent studies reported that changes of receptor expression could control the action of mediators on target cells. The initiation of different signaling pathways and, therefore, specific effects on cells, depends on certain components forming the cytokine-receptor complex. These mechanisms control the immune response and affect both the course of diseases (oncological, autoimmune, inflammatory) and the effectiveness of therapy. This review describes the potential of immune mediator receptors to regulate the efficiency of cytokine activity during pathologic processes and ensure the variability of their biological effects. Our aim was to investigate the spectrum of potential roles of changes in mediator recep...

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Characterization of Patients with Ibuprofen Hypersensitivity

Conclusion: In our cohort of patients, ibuprofen hypersensitivity affected females more commonly than males, and presented with mainly cutaneous manifestations. Onset of symptoms was rapid (#x3c; 60 min). Reactions typically ranged in severity from mild to moderate although there was a risk of severe anaphylaxis. There was potential cross-reactivity with other NSAIDs or acetaminophen. The results of our study contribute to the understanding of the demographics and clinical course of ibuprofen hypersensitivity reactions.Int Arch Allergy Immunol (Source: International Archives of Allergy and Immunology)

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Motor –vehicle accidents related maxillofacial injuries: a multicentre and prospective study

The purpose of this study is to obtain more precise information about the demographics and etiological/epidemiological patterns of MVA – related maxillofacial fractures of an European multicentre prospective study.

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The Reliability of MAML2 Gene Rearrangement in Discriminating Between Histologically Similar Glandular Odontogenic Cysts and Intraosseous Mucoepidermoid Carcinomas

MAML2 expression is proven in the majority of mucoepidermoid carcinomas (MEC) arising in salivary glands. MEC can also occur intraosseously (IMEC). Glandular odontogenic cyst (GOC) is an odontogenic cyst with histologic overlap with IMEC. This study will determine the reliability of MAML2 in distinguishing cases of IMEC from GOC.

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How well do we manage the odontogenic keratocyst? A multicenter study

To answer the clinical question: among patients treated for odontogenic keratocysts (OKCs), what is the overall 5-year disease-free rate and what factors are associated with disease recurrence?

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Mayo Clinic Minute: Holiday allergy triggers

For a person with?allergies, the holiday season can create challenges. Decorated trees,? roaring fires and a plate of Christmas cookies can lead to problems. ?A person who is allergic needs to be an advocate for himself, because it?s always better to be safe than sorry,??says Dr. Rohit Divekar, a Mayo Clinic allergic diseases specialist. You [...] (Source: News from Mayo Clinic)

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Removal of the articular fibrous layers with discectomy leads to temporomandibular joint ankylosis

The aim of this study was to investigate whether the direct damage of the articular fibrous layers without condylar fracture, combined with discectomy, was enough to induce temporomandibular joint (TMJ) ankylosis.

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Collagen/nano-sized β-tricalcium phosphate conduits combined with collagen filaments and nerve growth factor promote facial nerve regeneration in miniature swine: an in vivo study

We aimed to investigate the efficiency of a novel biomedical system that repairs facial nerve gaps in a miniature swine model.

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Diagnostic utility of microsurgical carbon-dioxide laser excision of oral potentially malignant lesions (OPMLs) vs incisional biopsy: a retrospective histopathological review

Complete excision of oral potentially malignant lesions (OPMLs) could result in improved and earlier detection of more severe grades of oral epithelial dysplasia and/or frank malignancy. Transoral micro-surgical carbon dioxide (CO2) laser techniques allow for resection of OPMLs, even those that are extensive. The advantages are improved diagnostic yield, improved viability of the specimen for pathologic evaluation reduced post-surgical morbidity and easier post-operative clinical surveillance.

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Medication Errors Resulting in Death Most Common in Elderly

Most common medication error category was omitted medicine or ingredient (Source: The Doctors Lounge - Psychiatry)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2rzMWWh

Mayo Clinic Minute: Holiday allergy triggers

For a person with?allergies, the holiday season can create challenges. Decorated trees,? roaring fires and a plate of Christmas cookies can lead to problems. ?A person who is allergic needs to be an advocate for himself, because it?s always better to be safe than sorry,??says Dr. Rohit Divekar, a Mayo Clinic allergic diseases specialist. You [...] (Source: News from Mayo Clinic)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2GgMiHl

Motor –vehicle accidents related maxillofacial injuries: a multicentre and prospective study

The purpose of this study is to obtain more precise information about the demographics and etiological/epidemiological patterns of MVA – related maxillofacial fractures of an European multicentre prospective study.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2zVr8cs

Collagen/nano-sized β-tricalcium phosphate conduits combined with collagen filaments and nerve growth factor promote facial nerve regeneration in miniature swine: an in vivo study

We aimed to investigate the efficiency of a novel biomedical system that repairs facial nerve gaps in a miniature swine model.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2zZ6XKG

The Reliability of MAML2 Gene Rearrangement in Discriminating Between Histologically Similar Glandular Odontogenic Cysts and Intraosseous Mucoepidermoid Carcinomas

MAML2 expression is proven in the majority of mucoepidermoid carcinomas (MEC) arising in salivary glands. MEC can also occur intraosseously (IMEC). Glandular odontogenic cyst (GOC) is an odontogenic cyst with histologic overlap with IMEC. This study will determine the reliability of MAML2 in distinguishing cases of IMEC from GOC.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PEDKd3

How well do we manage the odontogenic keratocyst? A multicenter study

To answer the clinical question: among patients treated for odontogenic keratocysts (OKCs), what is the overall 5-year disease-free rate and what factors are associated with disease recurrence?

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PEDFWN

Diagnostic utility of microsurgical carbon-dioxide laser excision of oral potentially malignant lesions (OPMLs) vs incisional biopsy: a retrospective histopathological review

Complete excision of oral potentially malignant lesions (OPMLs) could result in improved and earlier detection of more severe grades of oral epithelial dysplasia and/or frank malignancy. Transoral micro-surgical carbon dioxide (CO2) laser techniques allow for resection of OPMLs, even those that are extensive. The advantages are improved diagnostic yield, improved viability of the specimen for pathologic evaluation reduced post-surgical morbidity and easier post-operative clinical surveillance.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PEDASZ

Removal of the articular fibrous layers with discectomy leads to temporomandibular joint ankylosis

The aim of this study was to investigate whether the direct damage of the articular fibrous layers without condylar fracture, combined with discectomy, was enough to induce temporomandibular joint (TMJ) ankylosis.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2zVqYSo

Medication Errors Resulting in Death Most Common in Elderly

Most common medication error category was omitted medicine or ingredient (Source: The Doctors Lounge - Psychiatry)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

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Top News in Oncology December 13 2018 (8 of 8) - MD Linx

Top News in Oncology December 13 2018 (8 of 8)  MD Linx

If someone told you there was a vaccine that could prevent most cases of cervical cancer—and a growing number of head and neck cancers—would you get it?

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Huawei exec details health problems in affidavit submitted to BC court - Prince George Citizen

Huawei exec details health problems in affidavit submitted to BC court  Prince George Citizen

VANCOUVER — Huawei's chief financial officer says she has suffered a lifetime of health problems, including thyroid cancer, sleep apnea and high blood ...

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Top News in Oncology December 13 2018 (8 of 8) - MD Linx

Top News in Oncology December 13 2018 (8 of 8)  MD Linx

If someone told you there was a vaccine that could prevent most cases of cervical cancer—and a growing number of head and neck cancers—would you get it?

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Huawei exec details health problems in affidavit submitted to BC court - Prince George Citizen

Huawei exec details health problems in affidavit submitted to BC court  Prince George Citizen

VANCOUVER — Huawei's chief financial officer says she has suffered a lifetime of health problems, including thyroid cancer, sleep apnea and high blood ...

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Head And Neck Cancer Market Clinical Aspects, Review, Survey Reports 2018 to 2023 - Browse Live News

Head And Neck Cancer Market Clinical Aspects, Review, Survey Reports 2018 to 2023  Browse Live News

Global Head And Neck Cancer Market report provides a detailed analysis of the market from 2013 to 2023. The report provides comprehensive analysis for the ...

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Type I interferon/IRF7 axis instigates chemotherapy-induced immunological dormancy in breast cancer

Type I interferon/IRF7 axis instigates chemotherapy-induced immunological dormancy in breast cancer, Published online: 13 December 2018; doi:10.1038/s41388-018-0624-2Type I interferon/IRF7 axis instigates chemotherapy-induced immunological dormancy in breast cancer (Source: Oncogene)

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Potential efficacy and prognosis of silencing the CRLF2 ‑mediated AKT/mTOR pathway in pediatric acute B‑cell lymphoblastic leukemia.

Potential efficacy and prognosis of silencing the CRLF2‑mediated AKT/mTOR pathway in pediatric acute B‑cell lymphoblastic leukemia. Oncol Rep. 2018 Dec 07;: Authors: Jiang M, Zou X, Lu L Abstract Acute B‑cell lymphoblastic leukemia (B‑ALL) is a common type of blood cancer, which is associated with aberrant gene expression. Cytokine receptor‑like factor 2 (CRLF2) serves a crucial role in the growth and allergic and inflammatory responses of dendritic cells and T cells. The purpose of the present study was to investigate the potential therapeutic and prognostic effect of silencing the CRLF2‑mediated RAC‑α serine/threonine‑protein kinase (AKT)/serine/threonine‑protein kinase mTOR (mTOR) pathway in B‑ALL. In our study, bone marrow specimens were collec...

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

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Clinical Response to Subcutaneous < b > < i > Dermatophagoides pteronyssinus < /i > < /b > Immunotherapy in Children with Allergic Rhinitis and Asthma Is Independent of Sensitization to < b > < i > Blomia tropicalis < /i > < /b > Allergens

Conclusion: DP-SCIT may be of clinical benefit to patients with IgE sensitizations to both DP and BT. DP-SCIT induces IgG4 that cross-react with BT allergens.Int Arch Allergy Immunol (Source: International Archives of Allergy and Immunology)

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Corrigendum: Early Growth Response Gene-2 Is Essential for M1 and M2 Macrophage Activation and Plasticity by Modulation of the Transcription Factor CEBP β

Tatyana Veremeyko, Amanda W. Y. Yung, Daniel C. Anthony, Tatyana Strekalova, Eugene D. Ponomarev (Source: Frontiers in Immunology)

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Mediators of Inflammation - A Potential Source of Biomarkers in Oral Squamous Cell Carcinoma.

Authors: Tampa M, Mitran MI, Mitran CI, Sarbu MI, Matei C, Nicolae I, Caruntu A, Tocut SM, Popa MI, Caruntu C, Georgescu SR Abstract Oral squamous cell carcinoma (OSCC) is the most common tumour of the oral cavity, associated with significant morbidity and mortality. It is a multifactorial condition, both genetic and environmental factors being involved in its development and progression. Its pathogenesis is not fully elucidated, but a pivotal role has been attributed to inflammation, strong evidence supporting the association between chronic inflammation and carcinogenesis. Moreover, an increasing number of studies have investigated the role of different mediators of inflammation in the early detection of OSCC. In this review, we have summarized the main markers of inflammation th...

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

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