After consulting multiple doctors about her ongoing cough and congestion, LeeAnn Devore asked one of her physicians if she might have lung cancer. "He said ...
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Σάββατο 15 Δεκεμβρίου 2018
Targeting Innovation in Small Cell Lung Cancer - Curetoday.com
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Targeting Innovation in Small Cell Lung Cancer - Curetoday.com
After consulting multiple doctors about her ongoing cough and congestion, LeeAnn Devore asked one of her physicians if she might have lung cancer. "He said ...
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Differentiated Thyroid Cancer Therapeutics Market Research Report by Forecast (2018-2025) - Blue Bird Magazine
The Differentiated Thyroid Cancer Therapeutics Market 2018 Research Report (Request Sample Report Here) is collected with several market features, ...
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Head-To-Head Contrast: IDEXX Laboratories (IDXX) versus Response Genetics (OTCMKTS:RGDXQ) - Fairfield Current
IDEXX Laboratories (NASDAQ:IDXX) and Response Genetics (OTCMKTS:RGDXQ) are both medical companies, but which is the better investment? We will ...
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Differentiated Thyroid Cancer Therapeutics Market Research Report by Forecast (2018-2025) - Blue Bird Magazine
The Differentiated Thyroid Cancer Therapeutics Market 2018 Research Report (Request Sample Report Here) is collected with several market features, ...
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Head-To-Head Contrast: IDEXX Laboratories (IDXX) versus Response Genetics (OTCMKTS:RGDXQ) - Fairfield Current
IDEXX Laboratories (NASDAQ:IDXX) and Response Genetics (OTCMKTS:RGDXQ) are both medical companies, but which is the better investment? We will ...
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Negotiating the terms of engagement: Humor as a resource for managing interactional trouble in after-school tutoring encounters
Publication date: February 2019Source: Linguistics and Education, Volume 49Author(s): Anne PomerantzAbstractThis paper examines how tutors and tutees negotiate the terms of their engagement within the context of an after-school program in the United States of America that pairs university students with immigrant children from Bangladesh for the purpose of working through the children's homework assignments. Drawing on insights and approaches from linguistic ethnography, it argues that humor plays a meaningful yet overlooked role both in managing the transactional and interpersonal dimensions of homework help sessions and in illuminating the ongoing tensions and uncertainties at various levels of social organization that tutors and tutees encounter as they engage with one another. Likewise,...
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Scales and scalarity: Processing scalar inferences
Publication date: April 2019Source: Journal of Memory and Language, Volume 105Author(s): Bob van Tiel, Elizabeth Pankratz, Chao SunAbstractThe scalar word 'some' may be interpreted with an upper bound, i.e., as excluding 'all'. Several studies have found that the computation of this scalar inference may be associated with a processing cost (e.g., Bott & Noveck, 2004; De Neys & Schaeken, 2007), which seems to argue in favour of theories according to which pragmatic inferencing is cognitively demanding (e.g., Sperber & Wilson, 1986). This argument holds on the premise that findings for 'some' can be generalised across the entire family of scalar words, which has been called into question by recent work highlighting the diversity within the class of scalar words (e.g., van Tiel, v...
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Lexical characteristics of written language input across primary grades: An analysis of a Dutch corpus based lexicon
Publication date: February 2019Source: Linguistics and Education, Volume 49Author(s): Marlies de Zeeuw, Franc Grootjen, Gerrit Jan Kootstra, Agnes TellingsAbstractThe lexical written language input aimed at beginning readers may influence reading success. We analyzed a lexicon based on a corpus of Dutch reading materials for primary school children to gain insight into the frequency distribution of different word types, i.e. words with similar word characteristics, both per grade and across grades. The frequencies of monomorphemic, concrete words and of polysemous words remained relatively stable, whereas that of multimorphemic and monomorphemic abstract words increased across grades. Within each grade, multimorphemic and monomorphemic, abstract words had lower frequencies than monomorphem...
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Global Cyclin Dependent Kinase 9 Market CAGR 2018-2025 - Business Courier
Global Cyclin Dependent Kinase 9 Market CAGR 2018-2025 Business Courier
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The research report includes the present performance of the Cyclin Dependent Kinase 9 Industry, current trends in the global market and a detailed analysis of ...
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Coding and decoding of messages in human speech communication: implications for machine recognition of speech
Publication date: Available online 15 December 2018Source: Speech CommunicationAuthor(s): Hynek HermanskyAbstractThis paper postulates that linguistic message in speech is coded redundantly in both the time and the frequency domains. Such redundant coding of the message in the signal evolved over millennia of human evolution so that relevant spectral and temporal properties of human hearing can be used to extract these messages in the presence of noise. This view of human speech suggests a particular architecture of an automatic recognition (ASR) system in which longer temporal segments of spectrally-smoothed temporal trajectories of spectral energies in individual frequency bands of speech are used to derive estimates of the posterior probabilities of speech sounds. Combinations of these ...
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Seasonality in terai tree frog (Polypedates teraiensis): Role of light and temperature in regulation of seasonal breeding
Publication date: Available online 14 December 2018Source: Journal of Photochemistry and Photobiology B: BiologyAuthor(s): Bijoy Krishna Borah, Zothanmawii Renthlei, Amit Kumar TrivediAbstractSeasonality is represented as an initiation-termination-reinitiation of any physiological processes. Photoperiod is the most predictable environmental cue which organism use to time their daily physiology and seasonal functions. In natural light environmental conditions, day and night components change in terms of duration, intensity and spectrum of light available. In many vertebrate species, daytime light intensity and spectrum of light play a critical role in gonadal recrudescence-regression cycle. In tropical conditions, many amphibian species show a clear relationship between reproduction and sea...
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Singing voice: acoustic parameters after vocal warm-up and cool-down.
CONCLUSIONS: Our study highlights the effect of the vocal warm-up on acoustic parameters. The reduction in F0 observed after the cool-down session confirms its positive effect in helping professional vocal recovery and reducing vocal fold tension. PMID: 30522367 [PubMed - as supplied by publisher] (Source: Logopedics, Phoniatrics, Vocology.)
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Scales and scalarity: Processing scalar inferences
Publication date: April 2019Source: Journal of Memory and Language, Volume 105Author(s): Bob van Tiel, Elizabeth Pankratz, Chao SunAbstractThe scalar word 'some' may be interpreted with an upper bound, i.e., as excluding 'all'. Several studies have found that the computation of this scalar inference may be associated with a processing cost (e.g., Bott & Noveck, 2004; De Neys & Schaeken, 2007), which seems to argue in favour of theories according to which pragmatic inferencing is cognitively demanding (e.g., Sperber & Wilson, 1986). This argument holds on the premise that findings for 'some' can be generalised across the entire family of scalar words, which has been called into question by recent work highlighting the diversity within the class of scalar words (e.g., van Tiel, v...
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Lexical characteristics of written language input across primary grades: An analysis of a Dutch corpus based lexicon
Publication date: February 2019Source: Linguistics and Education, Volume 49Author(s): Marlies de Zeeuw, Franc Grootjen, Gerrit Jan Kootstra, Agnes TellingsAbstractThe lexical written language input aimed at beginning readers may influence reading success. We analyzed a lexicon based on a corpus of Dutch reading materials for primary school children to gain insight into the frequency distribution of different word types, i.e. words with similar word characteristics, both per grade and across grades. The frequencies of monomorphemic, concrete words and of polysemous words remained relatively stable, whereas that of multimorphemic and monomorphemic abstract words increased across grades. Within each grade, multimorphemic and monomorphemic, abstract words had lower frequencies than monomorphem...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2QAwgNc
Coding and decoding of messages in human speech communication: implications for machine recognition of speech
Publication date: Available online 15 December 2018Source: Speech CommunicationAuthor(s): Hynek HermanskyAbstractThis paper postulates that linguistic message in speech is coded redundantly in both the time and the frequency domains. Such redundant coding of the message in the signal evolved over millennia of human evolution so that relevant spectral and temporal properties of human hearing can be used to extract these messages in the presence of noise. This view of human speech suggests a particular architecture of an automatic recognition (ASR) system in which longer temporal segments of spectrally-smoothed temporal trajectories of spectral energies in individual frequency bands of speech are used to derive estimates of the posterior probabilities of speech sounds. Combinations of these ...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2BlNgfU
Negotiating the terms of engagement: Humor as a resource for managing interactional trouble in after-school tutoring encounters
Publication date: February 2019Source: Linguistics and Education, Volume 49Author(s): Anne PomerantzAbstractThis paper examines how tutors and tutees negotiate the terms of their engagement within the context of an after-school program in the United States of America that pairs university students with immigrant children from Bangladesh for the purpose of working through the children's homework assignments. Drawing on insights and approaches from linguistic ethnography, it argues that humor plays a meaningful yet overlooked role both in managing the transactional and interpersonal dimensions of homework help sessions and in illuminating the ongoing tensions and uncertainties at various levels of social organization that tutors and tutees encounter as they engage with one another. Likewise,...
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Seasonality in terai tree frog (Polypedates teraiensis): Role of light and temperature in regulation of seasonal breeding
Publication date: Available online 14 December 2018Source: Journal of Photochemistry and Photobiology B: BiologyAuthor(s): Bijoy Krishna Borah, Zothanmawii Renthlei, Amit Kumar TrivediAbstractSeasonality is represented as an initiation-termination-reinitiation of any physiological processes. Photoperiod is the most predictable environmental cue which organism use to time their daily physiology and seasonal functions. In natural light environmental conditions, day and night components change in terms of duration, intensity and spectrum of light available. In many vertebrate species, daytime light intensity and spectrum of light play a critical role in gonadal recrudescence-regression cycle. In tropical conditions, many amphibian species show a clear relationship between reproduction and sea...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2QAU9EC
Singing voice: acoustic parameters after vocal warm-up and cool-down.
CONCLUSIONS: Our study highlights the effect of the vocal warm-up on acoustic parameters. The reduction in F0 observed after the cool-down session confirms its positive effect in helping professional vocal recovery and reducing vocal fold tension. PMID: 30522367 [PubMed - as supplied by publisher] (Source: Logopedics, Phoniatrics, Vocology.)
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Global Cyclin Dependent Kinase 9 Market CAGR 2018-2025 - Business Courier
Global Cyclin Dependent Kinase 9 Market CAGR 2018-2025 Business Courier
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The research report includes the present performance of the Cyclin Dependent Kinase 9 Industry, current trends in the global market and a detailed analysis of ...
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Head and Neck Cancer Market: Business Opportunities, Current Trends, Market Challenges in 2026 - Coherent Times
Head and Neck Cancer Market: Business Opportunities, Current Trends, Market Challenges in 2026 Coherent Times
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Head and Neck Cancer Market has witnessed continuous growth in the past few years and is projected to grow even further during the forecast period ...
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Head and Neck Cancer Market: Business Opportunities, Current Trends, Market Challenges in 2026 - Coherent Times
Head and Neck Cancer Market: Business Opportunities, Current Trends, Market Challenges in 2026 Coherent Times
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Head and Neck Cancer Market has witnessed continuous growth in the past few years and is projected to grow even further during the forecast period ...
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Analyzing Vermillion (NASDAQ:VRML) and Response Genetics (RGDXQ) - Fairfield Current
Vermillion (NASDAQ:VRML) and Response Genetics (OTCMKTS:RGDXQ) are both small-cap medical companies, but which is the better stock? We will contrast ...
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Outcomes in sporadic vs familial medullary thyroid cancer | Head & Neck - MD Linx
Outcomes in sporadic vs familial medullary thyroid cancer | Head & Neck MD Linx
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Experts evaluated the clinical course of medullary thyroid carcinoma (MTC) with familial cases (fMTC) diagnosed earlier than sporadic MTC (spMTC).
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Analyzing Vermillion (NASDAQ:VRML) and Response Genetics (RGDXQ) - Fairfield Current
Vermillion (NASDAQ:VRML) and Response Genetics (OTCMKTS:RGDXQ) are both small-cap medical companies, but which is the better stock? We will contrast ...
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Outcomes in sporadic vs familial medullary thyroid cancer | Head & Neck - MD Linx
Outcomes in sporadic vs familial medullary thyroid cancer | Head & Neck MD Linx
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Experts evaluated the clinical course of medullary thyroid carcinoma (MTC) with familial cases (fMTC) diagnosed earlier than sporadic MTC (spMTC).
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Hundreds of St. Johns County firefighters receive life-saving hoods - FirstCoastNews.com WTLV-WJXX
Hundreds of St. Johns County firefighters receive life-saving hoods FirstCoastNews.com WTLV-WJXX
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ST. AUGUSTINE, Fla. — Hundreds St. Johns County firefighters received specialty hoods Saturday that could reduce their risk of developing cancer. A charity ...
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Hundreds of St. Johns County firefighters receive life-saving hoods - FirstCoastNews.com WTLV-WJXX
Hundreds of St. Johns County firefighters receive life-saving hoods FirstCoastNews.com WTLV-WJXX
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ST. AUGUSTINE, Fla. — Hundreds St. Johns County firefighters received specialty hoods Saturday that could reduce their risk of developing cancer. A charity ...
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Missouri Man Transforms His Life From Jail to Ultramarathons - U.S. News & World Report
Missouri Man Transforms His Life From Jail to Ultramarathons U.S. News & World Report
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COLUMBIA, Mo. (AP) — On a crisp October night, at least 20 people gathered in Three Creeks Conservation Area for the last run of the season. As he does for ...
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Missouri Man Transforms His Life From Jail to Ultramarathons - U.S. News & World Report
Missouri Man Transforms His Life From Jail to Ultramarathons U.S. News & World Report
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COLUMBIA, Mo. (AP) — On a crisp October night, at least 20 people gathered in Three Creeks Conservation Area for the last run of the season. As he does for ...
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Radford Arsenal Transparency and Virginia Tech Data Forge Positive Community Relations - WVTF
Radford Arsenal Transparency and Virginia Tech Data Forge Positive Community Relations WVTF
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After decades of suspicion about what exactly is going on at the Radford Arsenal in southwestern Virginia, community relations are improving. Not only did.
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Radford Arsenal Transparency and Virginia Tech Data Forge Positive Community Relations - WVTF
Radford Arsenal Transparency and Virginia Tech Data Forge Positive Community Relations WVTF
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After decades of suspicion about what exactly is going on at the Radford Arsenal in southwestern Virginia, community relations are improving. Not only did.
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Rapid Acquisition of Cytomegalovirus-Specific T Cells with a Differentiated Phenotype, in Non-Viremic Hematopoietic Stem Transplant Recipients Vaccinated with CMVPepVax
Cytomegalovirus (CMV) is one of the largest and most complex of all known viruses, with a genome encoding approximately 165 genes. CMV is widely prevalent globally, but is immunologically controlled in healthy individuals with an intact immune system. The immune effector mechanisms involved do not eliminate the virus or preclude transmission, but can control viral replication and prevent disease. High frequencies of CMV specific CD8 T cells are detectable in the peripheral blood of healthy individuals [1]. (Source: Biology of Blood and Marrow Transplantation)
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Efficacy of allergen-blocker mechanical barrier gel on symptoms and quality of life in patients with allergic rhinitis
ConclusionIn conclusion, we found significant decrease in all symptom scores and improvement in QoLS of patients treated with MBG as monotherapy and combination therapy. (Source: European Archives of Oto-Rhino-Laryngology)
MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
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Efficacy of allergen-blocker mechanical barrier gel on symptoms and quality of life in patients with allergic rhinitis
ConclusionIn conclusion, we found significant decrease in all symptom scores and improvement in QoLS of patients treated with MBG as monotherapy and combination therapy. (Source: European Archives of Oto-Rhino-Laryngology)
MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
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Rapid Acquisition of Cytomegalovirus-Specific T Cells with a Differentiated Phenotype, in Non-Viremic Hematopoietic Stem Transplant Recipients Vaccinated with CMVPepVax
Cytomegalovirus (CMV) is one of the largest and most complex of all known viruses, with a genome encoding approximately 165 genes. CMV is widely prevalent globally, but is immunologically controlled in healthy individuals with an intact immune system. The immune effector mechanisms involved do not eliminate the virus or preclude transmission, but can control viral replication and prevent disease. High frequencies of CMV specific CD8 T cells are detectable in the peripheral blood of healthy individuals [1]. (Source: Biology of Blood and Marrow Transplantation)
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Long-Term Lithium Use: More Evidence Needed to Associate With Cancer Risk - Psychiatry Advisor
The European Medicine Agency has reported that there may be an association between long-term lithium use and reports of both renal tumors and thyroid ...
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Long-Term Lithium Use: More Evidence Needed to Associate With Cancer Risk - Psychiatry Advisor
The European Medicine Agency has reported that there may be an association between long-term lithium use and reports of both renal tumors and thyroid ...
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10 subtle signs of thyroid cancer to look out for - Business Insider
10 subtle signs of thyroid cancer to look out for Business Insider
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The signs of thyroid cancer are not always clear-cut. Here are some signs to look out for.
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10 subtle signs of thyroid cancer to look out for - Business Insider
10 subtle signs of thyroid cancer to look out for Business Insider
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The signs of thyroid cancer are not always clear-cut. Here are some signs to look out for.
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Letter to the Editor on “MRI-based determination of occlusal splint thickness for temporomandibular joint disk derangement: a randomized controlled clinical trial.”
The recent article by Hegab et al., titled "MRI-based determination of occlusal splint thickness for temporomandibular joint disk derangement: a randomized controlled clinical trial", attempted to use MRI to assess the most effective vertical thickness of the occlusal splint for the management of TMJ internal derangement1. The authors drew a conclusion that an increase in splint thickness was associated with an increase in anteroposterior condylar movements, anteroposterior disk movements, and vertical condylar movements, and led to improved clinical outcomes.
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Letter to the Editor on “MRI-based determination of occlusal splint thickness for temporomandibular joint disk derangement: a randomized controlled clinical trial.”
The recent article by Hegab et al., titled "MRI-based determination of occlusal splint thickness for temporomandibular joint disk derangement: a randomized controlled clinical trial", attempted to use MRI to assess the most effective vertical thickness of the occlusal splint for the management of TMJ internal derangement1. The authors drew a conclusion that an increase in splint thickness was associated with an increase in anteroposterior condylar movements, anteroposterior disk movements, and vertical condylar movements, and led to improved clinical outcomes.
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Cyclin Dependent Kinase 9 Market 2018: Growth Analysis by Top Manufacturers Sales, Consumption Volume, Cost Structures Forecast 2023 - The Flatland Post
Newest Cyclin Dependent Kinase 9 market share and competition analysis report – made available by keeping global competition in mind. It provides key ...
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Cyclin Dependent Kinase 9 Market 2018: Growth Analysis by Top Manufacturers Sales, Consumption Volume, Cost Structures Forecast 2023 - The Flatland Post
Newest Cyclin Dependent Kinase 9 market share and competition analysis report – made available by keeping global competition in mind. It provides key ...
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Huawei exec details health problems in affidavit submitted to B.C. court - West Lorne Chronicle
I continue to feel unwell and I am worried about my health deteriorating while I am incarcerated," Meng Wanzhou says of her time at the Alouette Correctional ...
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Huawei exec details health problems in affidavit submitted to B.C. court - West Lorne Chronicle
I continue to feel unwell and I am worried about my health deteriorating while I am incarcerated," Meng Wanzhou says of her time at the Alouette Correctional ...
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Cancer warning: The hidden signs of tumours in your EARS - can you hear this noise? - Express
Cancer warning: The hidden signs of tumours in your EARS - can you hear this noise? Express
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CANCER symptoms vary depending on which part of the body is affected by a tumour. You could be at risk of deadly tumour signs if you often hear this noise in ...
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[Investigation of the diagnostic value of anti-dense fine speckled 70/lens epithelium derived growth factor p75 autoantibody for autoimmune diseases].
Authors: Türkoğlu G, Berkem R, Karakoç AE Abstract Antinuclear antibodies (ANA) are the autoantibodies that are produced against nuclear antigens in the cell nucleus and/or cytoplasm, and are one of the important diagnostic criteria in systemic autoimmune rheumatic diseases (SARD). Until today, several methods have been developed for detecting ANA's. However, indirect immunofluorescence (IIF) technique, that is also known as one of the oldest methods, is still the most commonly used one. Typically, anti-dense fine speckled 70/Lens epithelium derived growth factor p75 (anti-DFS70/LEDGF p75) autoantibody can be detected via IIF method where in HEp-2 (human larynx carcinoma) cells are used. The dense fine speckled (DFS) pattern method can be masked and remain unnoticed by the IIF m...
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Differentiation of Common Variable Immunodeficiency from Igg Deficiency
ConclusionCVID and IgG deficiency do not share the same disease spectrum, the former being associated with immunodysregulative manifestations and markers of a more severe immune defect. These data may allow clinicians to distinguish these conditions and the management differences that these patients pose. (Source: The Journal of Allergy and Clinical Immunology: In Practice)
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Differentiation of angioimmunoblastic T-cell lymphoma from DRESS syndrome
Publication date: Available online 14 December 2018Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Jiung Jeong, Da Woon Sim, Ji Eun Yu, Yoo Duk Choi, Seul Kee Kim, Woong Yoon, Young-Il Koh (Source: The Journal of Allergy and Clinical Immunology: In Practice)
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Hemophagocytic Lymphohistiocytosis: Clinical presentations and diagnosis
Publication date: Available online 14 December 2018Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Kimberly A. Risma, Rebecca A. MarshAbstractHemophagocytic lymphohistiocytosis (HLH) is an overwhelming clinical syndrome associated with extreme immune activation. Familial HLH is caused by autosomal recessive inheritance of gene mutations that cripple lymphocyte cytotoxicity. X-linked lymphoproliferative diseases and mutations in NLRC4 also feature HLH as a predominant manifestation. Additionally, "secondary" HLH may occur in immunocompromised patients or in individuals with previously intact immune responses in the context of strong immunologic triggers such as Epstein Barr Virus (EBV) infection, malignancy, rheumatologic disease, and drug hypersensitivity....
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Immediate Hypersensitivity to Polyethylene Glycols and Polysorbates: More Common Than We Have Recognized
ConclusionsImmediate hypersensitivity to PEG 3350 with cross-reactive polysorbate 80 hypersensitivity may be under recognized in clinical practice and can be detected with clinical skin testing. Our studies raise the possibility of an IgE mediated Type I hypersensitivity mechanism in some cases. (Source: The Journal of Allergy and Clinical Immunology: In Practice)
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The Journal of Allergy and Clinical Immunology: In Practice 2018 Highlights
This article provides highlights of the original research published in 2018 issues of JACI: In Practice on the subjects of anaphylaxis, asthma, dermatitis, drug allergy, eosinophilic disorders, food allergy, immune deficiency, rhinitis/upper respiratory disease, and urticaria/angioedema. Within each topic, practical aspects of diagnosis and management are emphasized. Treatments discussed include lifestyle modifications, allergen avoidance therapy, positive and negative effects of pharmacologic therapy, and various forms of immunologic and desensitization management. We hope this review will help readers consolidate and use this extensive and practical knowledge for the benefit of patients (Source: The Journal of Allergy and Clinical Immunology: In Practice)
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Drugs of porcine origin – a risk for patients with α-Gal syndrome?
Publication date: Available online 15 December 2018Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Kyra Swiontek, Martine Morisset, Françoise Codreanu-Morel, Jörg Fischer, Jana Mehlich, Ulf Darsow, Nadine Petitpain, Tilo Biedermann, Markus Ollert, Bernadette Eberlein, Christiane Hilger (Source: The Journal of Allergy and Clinical Immunology: In Practice)
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Harmonization of Terminology for Tolerated and Reactive Dose in Food Allergy Immunotherapy
Publication date: Available online 14 December 2018Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Thomas B. Casale, Tmirah Haselkorn, Christina E. Ciaccio, Panida Sriaroon, Bradley E. ChippsAbstractCurrently, there is no FDA-approved therapy for food allergy. Several new potential treatments are under investigation, including food allergen immunotherapy via various routes of administration, such as oral immunotherapy, epicutaneous therapy, subcutaneous immunotherapy, and sublingual immunotherapy. The double-blind, placebo-controlled food challenge has traditionally been used for diagnostic purposes, but extrapolation of the specific terminology used in food allergy diagnosis to interpretation of efficacy in clinical trials is incongruent and difficult to appl...
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Regulation of TIM-3 expression in a human T cell line by tumor-conditioned media and cyclic AMP-dependent signaling
Publication date: January 2019Source: Molecular Immunology, Volume 105Author(s): Su Jin Yun, Bokyoung Lee, Kuniharu Komori, Mi Jin Lee, Byoung Gill Lee, Kyongmin Kim, Sun ParkAbstractT cell immunoglobulin and mucin domain-3 (TIM-3) expression increases in exhausted T cells, which inhibits T cell function. TIM-3 expression is supposedly up-regulated in tumor-bearing individuals via chronic antigenic stimulation of T cells. Considering the immunosuppressive nature of the tumor microenvironment, we investigated whether tumor-secreted molecules might enhance TIM-3 expression in Jurkat T cells. We observed that TIM-3 expression was increased by the activation of prostaglandin (PG) E2 and cyclic AMP (cAMP) signaling pathways. Adenylate cyclase activation led to protein kinase A (PKA)-dependent u...
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[Evaluation of the reproductive potential of Encephalitozoon intestinalis in four different cell line].
In conclusion, this study compared the potential for reproduction of E.intestinalis in three human cell lines and monkey originated VERO cell line. This study demonstrated that cells derived from the tissues or organs where Microsporidia species causes disseminated infections could be infected by the parasitic spores in vitro. Additionally, the parasite can survive and propagate longer than six weeks. The authors believe that the results of this study will contribute to the further studies related to the parasite in the area of genetics, pharmacology, biochemistry, immunology and eradication studies. PMID: 30522424 [PubMed - in process] (Source: Mikrobiyoloji Bulteni)
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[Investigation of the diagnostic value of anti-dense fine speckled 70/lens epithelium derived growth factor p75 autoantibody for autoimmune diseases].
Authors: Türkoğlu G, Berkem R, Karakoç AE Abstract Antinuclear antibodies (ANA) are the autoantibodies that are produced against nuclear antigens in the cell nucleus and/or cytoplasm, and are one of the important diagnostic criteria in systemic autoimmune rheumatic diseases (SARD). Until today, several methods have been developed for detecting ANA's. However, indirect immunofluorescence (IIF) technique, that is also known as one of the oldest methods, is still the most commonly used one. Typically, anti-dense fine speckled 70/Lens epithelium derived growth factor p75 (anti-DFS70/LEDGF p75) autoantibody can be detected via IIF method where in HEp-2 (human larynx carcinoma) cells are used. The dense fine speckled (DFS) pattern method can be masked and remain unnoticed by the IIF m...
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The Journal of Allergy and Clinical Immunology: In Practice 2018 Highlights
This article provides highlights of the original research published in 2018 issues of JACI: In Practice on the subjects of anaphylaxis, asthma, dermatitis, drug allergy, eosinophilic disorders, food allergy, immune deficiency, rhinitis/upper respiratory disease, and urticaria/angioedema. Within each topic, practical aspects of diagnosis and management are emphasized. Treatments discussed include lifestyle modifications, allergen avoidance therapy, positive and negative effects of pharmacologic therapy, and various forms of immunologic and desensitization management. We hope this review will help readers consolidate and use this extensive and practical knowledge for the benefit of patients (Source: The Journal of Allergy and Clinical Immunology: In Practice)
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Cancer warning: The hidden signs of tumours in your EARS - can you hear this noise? - Express
Cancer warning: The hidden signs of tumours in your EARS - can you hear this noise? Express
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CANCER symptoms vary depending on which part of the body is affected by a tumour. You could be at risk of deadly tumour signs if you often hear this noise in ...
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Differentiation of angioimmunoblastic T-cell lymphoma from DRESS syndrome
Publication date: Available online 14 December 2018Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Jiung Jeong, Da Woon Sim, Ji Eun Yu, Yoo Duk Choi, Seul Kee Kim, Woong Yoon, Young-Il Koh (Source: The Journal of Allergy and Clinical Immunology: In Practice)
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Real-World Attitudes Among Allergists/Immunologists Regarding Oral Immunotherapy and Preferred Terminology
Publication date: Available online 14 December 2018Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Bradley E. Chipps, Christina E. Ciaccio, Karin Rosén, Tmirah Haselkorn, Ellen Zigmont, Thomas B. Casale (Source: The Journal of Allergy and Clinical Immunology: In Practice)
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Hemophagocytic Lymphohistiocytosis: Clinical presentations and diagnosis
Publication date: Available online 14 December 2018Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Kimberly A. Risma, Rebecca A. MarshAbstractHemophagocytic lymphohistiocytosis (HLH) is an overwhelming clinical syndrome associated with extreme immune activation. Familial HLH is caused by autosomal recessive inheritance of gene mutations that cripple lymphocyte cytotoxicity. X-linked lymphoproliferative diseases and mutations in NLRC4 also feature HLH as a predominant manifestation. Additionally, "secondary" HLH may occur in immunocompromised patients or in individuals with previously intact immune responses in the context of strong immunologic triggers such as Epstein Barr Virus (EBV) infection, malignancy, rheumatologic disease, and drug hypersensitivity....
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Comparison of International Systemic Adverse Reactions due to Allergen Immunotherapy
ConclusionDespite having a lower correlation than EAACI and AAAAI/ACAAI, the WAO grading appears to provide a moderate correlation among these classifications. The analysis might help to inform clinicians and investigators on selecting the most appropriate classification. (Source: The Journal of Allergy and Clinical Immunology: In Practice)
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Immediate Hypersensitivity to Polyethylene Glycols and Polysorbates: More Common Than We Have Recognized
ConclusionsImmediate hypersensitivity to PEG 3350 with cross-reactive polysorbate 80 hypersensitivity may be under recognized in clinical practice and can be detected with clinical skin testing. Our studies raise the possibility of an IgE mediated Type I hypersensitivity mechanism in some cases. (Source: The Journal of Allergy and Clinical Immunology: In Practice)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2rEesSt
Harmonization of Terminology for Tolerated and Reactive Dose in Food Allergy Immunotherapy
Publication date: Available online 14 December 2018Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Thomas B. Casale, Tmirah Haselkorn, Christina E. Ciaccio, Panida Sriaroon, Bradley E. ChippsAbstractCurrently, there is no FDA-approved therapy for food allergy. Several new potential treatments are under investigation, including food allergen immunotherapy via various routes of administration, such as oral immunotherapy, epicutaneous therapy, subcutaneous immunotherapy, and sublingual immunotherapy. The double-blind, placebo-controlled food challenge has traditionally been used for diagnostic purposes, but extrapolation of the specific terminology used in food allergy diagnosis to interpretation of efficacy in clinical trials is incongruent and difficult to appl...
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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2LjGBYb
Regulation of TIM-3 expression in a human T cell line by tumor-conditioned media and cyclic AMP-dependent signaling
Publication date: January 2019Source: Molecular Immunology, Volume 105Author(s): Su Jin Yun, Bokyoung Lee, Kuniharu Komori, Mi Jin Lee, Byoung Gill Lee, Kyongmin Kim, Sun ParkAbstractT cell immunoglobulin and mucin domain-3 (TIM-3) expression increases in exhausted T cells, which inhibits T cell function. TIM-3 expression is supposedly up-regulated in tumor-bearing individuals via chronic antigenic stimulation of T cells. Considering the immunosuppressive nature of the tumor microenvironment, we investigated whether tumor-secreted molecules might enhance TIM-3 expression in Jurkat T cells. We observed that TIM-3 expression was increased by the activation of prostaglandin (PG) E2 and cyclic AMP (cAMP) signaling pathways. Adenylate cyclase activation led to protein kinase A (PKA)-dependent u...
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Adipose-derived stem cell research, worry and hope
In the wake of call for retractions of papers from Harvard University heart stem cell research lab, the public concerns had been raised about stem cell researches, including adipose-derived stem cells (ADSCs).
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Four corner fusion: Comparing outcomes of conventional K-wire-, locking plate-, and retrograde headless compression screw fixation
Several operative approaches and various implants for osseous fixation have been described to achieve four-corner fusion of the wrist. Given the discordance and to aid in further standardizing the technique, this study directly compares the outcomes of K-wire-, fusion-plate, and headless retrograde compressive screw-fixation to achieve four-corner arthrodesis.
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Nerve transfer of the anterior interosseous nerve to the thenar branch of the median nerve – an anatomical and histological analysis
Nerve transfer has become a vital method in the reconstruction of hand function. Reconstructing the motor function to the thenar musculature has proven to be difficult and is rarely satisfactory following direct anatomic repair. Aim of this investigation was to describe the anatomic results obtained by transferring the anterior interosseous nerve to the thenar branch of the median nerve and analyze the histomorphometric results.
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Letter re "Anesthesia for collagenase clostridium histolyticum injection in patients with dupuytren disease: A cohort analysis"
Sanjuan-Cervero et al. 1 report that patients undergoing collagenase injections for the treatment of Dupuytren's contracture report less pain if a wrist block is performed first. Unfortunately the authors did not account for the pain of 10mls of mepivacaine being injected through two injections at the wrist.
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What exactly is a thyroid disorder? 20 things experts want us all to know about this vital gland - Irish Examiner
Thyroid disorders are believed to affect around one in 20 people in the UK, yet because the symptoms – such as weight changes, depression and fatigue – can ...
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Reply to: “Updated guidelines on complex regional pain syndrome in adults”
We read with interest the article by Dr. Henderson "Updated guidelines on complex regional pain syndrome in adults." 1 The article provides an elegant summary of the Royal College of Physicians (RCP) current guidelines in the diagnosis and treatment of complex regional pain syndrome (CRPS) and recommends surgical intervention for the treatment of Type 2 CRPS (i.e. CRPS with a recognized nerve injury). However, it fails to identify the timing of such interventions. This is important considering the emerging paradigm shift in concepts of nerve pain, specifically 'centralization' of pain in neuroma patients with delayed presentations.
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Response to “Reply to: “Updated guidelines on complex regional pain syndrome in adults””
I thank Drs Zeiderman and Pereira for their kind words and constructive comments. The Royal College of Physicians guidelines do not absolutely recommend surgery for all cases of type II CRPS, but recognize that it might be appropriate where nerve injury or entrapment are confidently diagnosed (e.g. with nerve conduction tests).
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Response to the comment of Mr. J. Henderson on paper “Anaesthesia in the Colagenase Clostridium Histolyticum Injection for Dupuytren's Disease: A Cohort Analysis”
Dear Sir,
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CO2 Laser Treatment for Burn Scarring
Burn scars are usually characterised by a combination of hypertrophic and keloid scars that are often very challenging to treat. They are a consequence of abnormal collagen deposition by fibroblasts exhibiting a hypersensitive response to growth factors.1 These scars can have a profound effect on patients both functionally and psychologically due to their poor cosmesis and debilitating symptoms.2 Currently there is no reliable or satisfactory treatment available to address the long-term sequelae of burns, however, more recently the use of laser-based treatments has been attributed to a paradigm shift in the management of burn scarring.
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Commentary on JPRAS-D-18-00185: The Use of Laser Speckle Contrast Imaging to predict flap necrosis - an experimental study in a porcine flap model Article
The authors need to be congratulated for their fine study on the use of Laser Speckle Contrast Imaging (LSCI) to predict flap necrosis in an experimental setting with a porcine pedicled flap model. LSCI has been repeatedly described for perfusion analysis in flap surgery. There has always been a demand to simplify or optimize intra- and postoperative flap monitoring, especially in free flap surgery. However, the individual techniques to postoperatively monitor free flaps vary considerably. In former studies from the early 1990ies with questionnaires ninety percent of microsurgeons reported to routinely use monitoring devices, with external and laser doppler having achieved greatest popularity.
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$5.73 Million in Sales Expected for Interpace Diagnostics Group Inc (IDXG) This Quarter - Fairfield Current
Equities analysts expect that Interpace Diagnostics Group Inc (NASDAQ:IDXG) will report sales of $5.73 million for the current fiscal quarter, Zacks Investment ...
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Thyroid cancer impact on children and teens following Fukushima nuclear accident - thejournal.ie
OVER 180 TEENAGERS and children have been found to have thyroid cancer or suspected cancer following the Fukushima nuclear accident, new research has ...
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Response to the comment of Mr. J. Henderson on paper “Anaesthesia in the Colagenase Clostridium Histolyticum Injection for Dupuytren's Disease: A Cohort Analysis”
Dear Sir,
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Thyroid cancer impact on children and teens following Fukushima nuclear accident - thejournal.ie
OVER 180 TEENAGERS and children have been found to have thyroid cancer or suspected cancer following the Fukushima nuclear accident, new research has ...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2LjtiXL
Letter re "Anesthesia for collagenase clostridium histolyticum injection in patients with dupuytren disease: A cohort analysis"
Sanjuan-Cervero et al. 1 report that patients undergoing collagenase injections for the treatment of Dupuytren's contracture report less pain if a wrist block is performed first. Unfortunately the authors did not account for the pain of 10mls of mepivacaine being injected through two injections at the wrist.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PHCt4G
Reply to: “Updated guidelines on complex regional pain syndrome in adults”
We read with interest the article by Dr. Henderson "Updated guidelines on complex regional pain syndrome in adults." 1 The article provides an elegant summary of the Royal College of Physicians (RCP) current guidelines in the diagnosis and treatment of complex regional pain syndrome (CRPS) and recommends surgical intervention for the treatment of Type 2 CRPS (i.e. CRPS with a recognized nerve injury). However, it fails to identify the timing of such interventions. This is important considering the emerging paradigm shift in concepts of nerve pain, specifically 'centralization' of pain in neuroma patients with delayed presentations.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2LhEtA2
Four corner fusion: Comparing outcomes of conventional K-wire-, locking plate-, and retrograde headless compression screw fixation
Several operative approaches and various implants for osseous fixation have been described to achieve four-corner fusion of the wrist. Given the discordance and to aid in further standardizing the technique, this study directly compares the outcomes of K-wire-, fusion-plate, and headless retrograde compressive screw-fixation to achieve four-corner arthrodesis.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2LjtjuN
Complications after lower body contouring surgery due to massive weight loss unaffected by weight loss method
Body contouring surgery following massive weight loss positively affects patient quality of life. However, the procedure is prone to complications. Here, we stratified complications time-wise. Furthermore, we examined whether the weight loss method — bariatric surgery or lifestyle changes — affected the frequency or severity of complications. In this single-centre retrospective analysis, we included 158 massive weight loss patients undergoing body contouring surgery between 2009 and 2015. We recorded 96 complications in 80 patients, with an overall rate of 51%.
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Response to “Reply to: “Updated guidelines on complex regional pain syndrome in adults””
I thank Drs Zeiderman and Pereira for their kind words and constructive comments. The Royal College of Physicians guidelines do not absolutely recommend surgery for all cases of type II CRPS, but recognize that it might be appropriate where nerve injury or entrapment are confidently diagnosed (e.g. with nerve conduction tests).
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2UHus3s
CO2 Laser Treatment for Burn Scarring
Burn scars are usually characterised by a combination of hypertrophic and keloid scars that are often very challenging to treat. They are a consequence of abnormal collagen deposition by fibroblasts exhibiting a hypersensitive response to growth factors.1 These scars can have a profound effect on patients both functionally and psychologically due to their poor cosmesis and debilitating symptoms.2 Currently there is no reliable or satisfactory treatment available to address the long-term sequelae of burns, however, more recently the use of laser-based treatments has been attributed to a paradigm shift in the management of burn scarring.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PJxcKc
Commentary on JPRAS-D-18-00185: The Use of Laser Speckle Contrast Imaging to predict flap necrosis - an experimental study in a porcine flap model Article
The authors need to be congratulated for their fine study on the use of Laser Speckle Contrast Imaging (LSCI) to predict flap necrosis in an experimental setting with a porcine pedicled flap model. LSCI has been repeatedly described for perfusion analysis in flap surgery. There has always been a demand to simplify or optimize intra- and postoperative flap monitoring, especially in free flap surgery. However, the individual techniques to postoperatively monitor free flaps vary considerably. In former studies from the early 1990ies with questionnaires ninety percent of microsurgeons reported to routinely use monitoring devices, with external and laser doppler having achieved greatest popularity.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2UQIjo2
$5.73 Million in Sales Expected for Interpace Diagnostics Group Inc (IDXG) This Quarter - Fairfield Current
Equities analysts expect that Interpace Diagnostics Group Inc (NASDAQ:IDXG) will report sales of $5.73 million for the current fiscal quarter, Zacks Investment ...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2UL0zPO
What exactly is a thyroid disorder? 20 things experts want us all to know about this vital gland - Irish Examiner
Thyroid disorders are believed to affect around one in 20 people in the UK, yet because the symptoms – such as weight changes, depression and fatigue – can ...
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Nuclear Theranostics in Turkey
Abstract
Nuclear theranostics functions as a bridge which connects targeted diagnosis to targeted therapy, just like Turkey functions as a geographical bridge which connects Asia to Europe. This unique geographical site of the country plays an important role with regard to introduction of novel scientific and technologic improvements, which originate from one continent to another, in the era of accelerated information. The first nuclear medicine practice in Turkey started in the beginning of 1950s with the first radioiodine treatment, which actually was a debut for nuclear theranostics in Turkey, years before many other countries in the world. For the time being, along with radioiodine treatment, many other theranostic applications such as I-131 MIBG treatment, Lu-177/Y-90 DOTA peptide treatment, Lu-177 PSMA treatment, Y-90 microsphere treatment, and bone palliative treatment are being performed in many centers countrywide. As science and technology improves, novel theranostic applications are eagerly awaited to be introduced in near future. This paper summarizes the story of nuclear theranostics in Turkey and aims to give an overview on the current status of theranostic applications in Turkey.
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Activities for the Development of Targeted Radionuclide Therapy in Japan
Abstract
Targeted radionuclide therapy (TRT) is unique because of its efficacy and its theranostic feature in the era of precision medicine. So far, introduction of new TRT has not been going well in Japan due to several reasons including strict regulations, shortage of facilities for TRT, and insufficient reimbursement for TRT in clinic. Japanese community had several strategies to develop TRT in these 10 years, including the establishment of the National Conference for Nuclear Medicine Theranostics in which physicians, scientists, patients, people supporting patients, and industrial people gather. To promote TRT with supports from the government, the preparatory committee for the establishment of Japan Foundation of Medical Isotope Development (JAFMID) was launched. I would like to call TRT "Precision Nuclear Medicine." When we can add genomic information here, we can put it to new stage of cancer therapy. It is time for us.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2QwjLSW
Anaphylactic reaction caused by skin contact with disinfectant chloramine‐T.
Chloramine‐T (CAS no. 7080‐50‐4, syn. sodium p‐toluenesulfonchloramide) is a crystalline powder on a chlorine basis, commonly used as a sterilizer, antiseptic, disinfectant and chemical reagent. Sensitization is often work related. We report a case of an anaphylactic reaction to chloramine‐T.
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Skin tape stripping: which layers of the epidermis are removed?
Skin biopsies represent the gold standard for investigating skin immunology and biomarkers.1 However, biopsies cause discomfort, bleeding, minor scarring and, rarely, skin infections. Accordingly, non‐invasive techniques are increasingly popular in dermatological research.2,3 Among these, the tape‐strip method is commonly used for obtaining skin cells, but validation showing how many cell layers are removed with this sampling method has not yet adequately been performed. In this study, we determined the number of epidermal cell layers that is removed when tape‐stripping skin using two different adhesive materials.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2QvRj3u
Activities for the Development of Targeted Radionuclide Therapy in Japan
Abstract
Targeted radionuclide therapy (TRT) is unique because of its efficacy and its theranostic feature in the era of precision medicine. So far, introduction of new TRT has not been going well in Japan due to several reasons including strict regulations, shortage of facilities for TRT, and insufficient reimbursement for TRT in clinic. Japanese community had several strategies to develop TRT in these 10 years, including the establishment of the National Conference for Nuclear Medicine Theranostics in which physicians, scientists, patients, people supporting patients, and industrial people gather. To promote TRT with supports from the government, the preparatory committee for the establishment of Japan Foundation of Medical Isotope Development (JAFMID) was launched. I would like to call TRT "Precision Nuclear Medicine." When we can add genomic information here, we can put it to new stage of cancer therapy. It is time for us.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2QwjLSW
Nuclear Theranostics in Turkey
Abstract
Nuclear theranostics functions as a bridge which connects targeted diagnosis to targeted therapy, just like Turkey functions as a geographical bridge which connects Asia to Europe. This unique geographical site of the country plays an important role with regard to introduction of novel scientific and technologic improvements, which originate from one continent to another, in the era of accelerated information. The first nuclear medicine practice in Turkey started in the beginning of 1950s with the first radioiodine treatment, which actually was a debut for nuclear theranostics in Turkey, years before many other countries in the world. For the time being, along with radioiodine treatment, many other theranostic applications such as I-131 MIBG treatment, Lu-177/Y-90 DOTA peptide treatment, Lu-177 PSMA treatment, Y-90 microsphere treatment, and bone palliative treatment are being performed in many centers countrywide. As science and technology improves, novel theranostic applications are eagerly awaited to be introduced in near future. This paper summarizes the story of nuclear theranostics in Turkey and aims to give an overview on the current status of theranostic applications in Turkey.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Bn11uG
Anaphylactic reaction caused by skin contact with disinfectant chloramine‐T.
Chloramine‐T (CAS no. 7080‐50‐4, syn. sodium p‐toluenesulfonchloramide) is a crystalline powder on a chlorine basis, commonly used as a sterilizer, antiseptic, disinfectant and chemical reagent. Sensitization is often work related. We report a case of an anaphylactic reaction to chloramine‐T.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2BqgB8L
Skin tape stripping: which layers of the epidermis are removed?
Skin biopsies represent the gold standard for investigating skin immunology and biomarkers.1 However, biopsies cause discomfort, bleeding, minor scarring and, rarely, skin infections. Accordingly, non‐invasive techniques are increasingly popular in dermatological research.2,3 Among these, the tape‐strip method is commonly used for obtaining skin cells, but validation showing how many cell layers are removed with this sampling method has not yet adequately been performed. In this study, we determined the number of epidermal cell layers that is removed when tape‐stripping skin using two different adhesive materials.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2QvRj3u
Deep sequencing salivary proteins for periodontitis using proteomics
Abstract
Objectives
Saliva is a bodily fluid transuded from gingival crevice fluid and blood and contains many proteins. Proteins in saliva have been studied as markers for periodontal diseases. Mass spectrometric analysis is applied to investigate biomarker proteins that are related to periodontitis.
Material and methods
Saliva samples were collected from 207 participants including 36 pairs matched for age, sex, and smoking who joined Yangpyeong health cohort. Periodontitis was defined by 2005 5th European guideline. Shotgun proteomics was applied to detect proteins from saliva samples. Principal component analysis and Ingenuity Pathway Analysis for canonical pathway and protein pathway were applied. Protein-protein interaction was also applied. Enzyme-linked immunosorbent assay (ELISA) was used to verify the candidate protein markers among another matched participants (n = 80).
Results
Shotgun proteomics indicated that salivary S100A8 and S100A9 were candidate biomarkers for periodontitis. ELISA confirmed that both salivary S100A8 and S100A9 were higher in those with periodontitis compared to those without periodontitis (paired-t test, p < 0.05).
Conclusion
Our proteomics data showed that S100A8 and S100A9 in saliva could be candidate biomarkers for periodontitis. The rapid-test-kit using salivary S100A8 and S100A9 will be a practical tool for reducing the risk of periodontitis and promotion of periodontal health.
Clinical relevance
A rapid-test-kit using salivary biomarkers, S100A8 and S100A9, could be utilized by clinicians and individuals for screening periodontitis, which might reduce the morbidity of periodontitis and promote periodontal health.
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Deep sequencing salivary proteins for periodontitis using proteomics
Abstract
Objectives
Saliva is a bodily fluid transuded from gingival crevice fluid and blood and contains many proteins. Proteins in saliva have been studied as markers for periodontal diseases. Mass spectrometric analysis is applied to investigate biomarker proteins that are related to periodontitis.
Material and methods
Saliva samples were collected from 207 participants including 36 pairs matched for age, sex, and smoking who joined Yangpyeong health cohort. Periodontitis was defined by 2005 5th European guideline. Shotgun proteomics was applied to detect proteins from saliva samples. Principal component analysis and Ingenuity Pathway Analysis for canonical pathway and protein pathway were applied. Protein-protein interaction was also applied. Enzyme-linked immunosorbent assay (ELISA) was used to verify the candidate protein markers among another matched participants (n = 80).
Results
Shotgun proteomics indicated that salivary S100A8 and S100A9 were candidate biomarkers for periodontitis. ELISA confirmed that both salivary S100A8 and S100A9 were higher in those with periodontitis compared to those without periodontitis (paired-t test, p < 0.05).
Conclusion
Our proteomics data showed that S100A8 and S100A9 in saliva could be candidate biomarkers for periodontitis. The rapid-test-kit using salivary S100A8 and S100A9 will be a practical tool for reducing the risk of periodontitis and promotion of periodontal health.
Clinical relevance
A rapid-test-kit using salivary biomarkers, S100A8 and S100A9, could be utilized by clinicians and individuals for screening periodontitis, which might reduce the morbidity of periodontitis and promote periodontal health.
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Definitive RT + cisplatin or cetuximab in head and neck cancer | Cancer - MD Linx
Definitive RT + cisplatin or cetuximab in head and neck cancer | Cancer MD Linx
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Internal Medicine Article: Survival of patients with head and neck cancer treated with definitive radiotherapy and concurrent cisplatin or concurrent cetuximab: A ...
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Excess body weight responsible for 3.9% of cancer globally - WREG NewsChannel 3
Excess body weight responsible for 3.9% of cancer globally WREG NewsChannel 3
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NEW YORK — Excess body weight was responsible for 3.9% of cancer globally, or 544,300 cases, in 2012, according to a new report.
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Definitive RT + cisplatin or cetuximab in head and neck cancer | Cancer - MD Linx
Definitive RT + cisplatin or cetuximab in head and neck cancer | Cancer MD Linx
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Internal Medicine Article: Survival of patients with head and neck cancer treated with definitive radiotherapy and concurrent cisplatin or concurrent cetuximab: A ...
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Excess body weight responsible for 3.9% of cancer globally - WREG NewsChannel 3
Excess body weight responsible for 3.9% of cancer globally WREG NewsChannel 3
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NEW YORK — Excess body weight was responsible for 3.9% of cancer globally, or 544,300 cases, in 2012, according to a new report.
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High correlation between human rhinovirus type C and children with asthma exacerbations in Taiwan
ConclusionsHRV is the most predominant viral infection responsible for pediatric AE in Taiwan, and HRV-C is responsible for more of these exacerbations than HRV-A or HRV-B. (Source: Journal of Microbiology, Immunology and Infection)
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High correlation between human rhinovirus type C and children with asthma exacerbations in Taiwan
ConclusionsHRV is the most predominant viral infection responsible for pediatric AE in Taiwan, and HRV-C is responsible for more of these exacerbations than HRV-A or HRV-B. (Source: Journal of Microbiology, Immunology and Infection)
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Teen diagnosed with thyroid cancer reveals hospital support that made life 'bearable' - Mirror Online
Teen diagnosed with thyroid cancer reveals hospital support that made life 'bearable' Mirror Online
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Shannon Hawthorne felt less isolated after confiding in a Teenage Cancer Trust nurse who discussed her fears and helped her meet other teens in the same ...
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Teen diagnosed with thyroid cancer reveals hospital support that made life 'bearable' - Mirror Online
Teen diagnosed with thyroid cancer reveals hospital support that made life 'bearable' Mirror Online
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Shannon Hawthorne felt less isolated after confiding in a Teenage Cancer Trust nurse who discussed her fears and helped her meet other teens in the same ...
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Definitive RT + cisplatin or cetuximab in head and neck cancer | Cancer - MD Linx
Definitive RT + cisplatin or cetuximab in head and neck cancer | Cancer MD Linx
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Otolaryngology Article: Survival of patients with head and neck cancer treated with definitive radiotherapy and concurrent cisplatin or concurrent cetuximab: A ...
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Salivary gland tumors: Molecular characterization and therapeutic advances for metastatic disease
Abstract
Salivary gland cancers represent a rare group of tumors composed by over 20 histological subtypes. Initially treated as one single disease, its diagnosis, prognosis, and treatment are currently being stratified based on morphology. More recently, insight has been provided on the molecular characterization of each subtype, further improving diagnostic accuracy and paving the way for personalized therapy. In this article, we provide a comprehensive review of recent breakthroughs, preliminary results of novel therapy, and future directions on the treatment of these complex malignancies.
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Expression of CD44, EGFR, p16, and their mutual combinations in patients with head and neck cancer: Impact on outcomes of intensity‐modulated radiation therapy
Abstract
Background
Progress in radiation treatment of head and neck squamous cell carcinoma (HNSCC) deserves the studies focused on molecular predictors that would help to enhance individually tailored treatment.
Methods
p16/epidermal growth factor receptor (EGFR)/cluster of differentiation‐44 (CD44) was immunohistochemically analyzed in 165 HNSCC patients.
Results
In the entire group and the p16 negative cohort, better 3‐year overall survival and locoregional control correlated with p16 positivity, CD44, and EGFR negativity were observed. Combined analysis revealed the worst results in the CD44+/p16−, EGFR+/p16−, and EGFR+/CD44+ groups and in the EGFR+/CD44+ within p16 negative cohort. Multivariate analysis found tumor stage, Karnofsky index, p16, and CD44 as prognostic factors of overall survival and clinical stage, and p16 as a prognostic factor for locoregional control. Clinical stage and Karnofsky index affected overall survival and tumor stage. EGFR affected locoregional control in the p16 negative subgroup.
Conclusion
Our study confirmed the negative effect of CD44 and EGFR and the positive effect of p16 on radiotherapy results.
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Reply to Letter to the Editor regarding “Carbon Dioxide Embolism during Transoral Robotic Thyroidectomy: A Case Report”
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Effect of radiotherapy on the chemical composition of root dentin
Abstract
Background
The radiotherapy can directly affect the bond strength of the adhesive materials, interfering in the prognosis of restorative treatments, which may be caused by chemical changes in dentin structure.
Methods
Twenty inferior homologues premolars were distributed in 2 groups (in vitro study) (n = 10): nonirradiated and irradiated. The specimens were submitted to the analysis of phosphate (ν1PO43−;ν2PO43−;ν4PO43−), carbonate (ν3CO32−), amide I, CH2, amide III, and amide I/III ratio by confocal Raman spectroscopy. Data were submitted to statistical analysis (T test, P < .05).
Results
In intracanal dentin, the irradiated group had lower ν4PO43− values (1.23 ± 0.06) compared to nonirradiated group (1.40 ± 0.18) (P < .05), with no difference for ν1PO43− and ν2PO43 peaks (P > .05). The irradiated (1.56 ± 0.06) had lower carbonate, amide III (1.05 ± 0.19), and amide I/III ratio values (0.19 ± 0.06) compared to nonirradiated group (1.42 ± 0.10, 1.28 ± 0.24, and 0.31 ± 0.10, respectively) (P < .05). For medium dentin irradiated group (1.30 ± 0.12) had lower phosphate values compared to nonirradiated group (1.48 ± 0.22) (P < .05). In cementum, there was no statistical difference between the groups.
Conclusion
The radiotherapy was able to cause changes in ν4PO43−, carbonate, and amide III peaks of root dentin.
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Prospective instrumental evaluation of swallowing, tongue function, and QOL measures following transoral robotic surgery alone without adjuvant therapy
Abstract
Background
Transoral robotic surgery (TORS) has been utilized to deintensify treatment. No studies have measured swallow safety and efficiency, nor assessed the functional impact of TORS alone.
Methods
This prospective cohort underwent baseline and 1‐month postsurgery assessments including modified barium swallow evaluation, using the Dynamic Imaging Grade of Swallowing Toxicity (DIGEST) rating system, tongue range of motion assessment, the Performance Status Scale (PSS), and quality of life with the MD Anderson Dysphagia Inventory (MDADI).
Results
All DIGEST safety scores were 0 (normal) at both time points. DIGEST efficiency scores were mildly impaired in 2 of 10 patients postsurgery. PSS scores revealed all patients were on regular diets, were 100% understandable, and were eating in public at both time points. Tongue Range of Motion scores were 100 of 100 at both time points. MDADI scores were not significantly different across time points.
Conclusions
Careful identification of patients can result in excellent outcomes following TORS. Future studies will examine longer follow‐up of speech, swallowing, and tongue function in patients undergoing TORS surgery.
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The DAHANCA 32 study: Electrochemotherapy for recurrent mucosal head and neck cancer
Abstract
Background
Electrochemotherapy is an established treatment for cutaneous tumors. This study aimed at determining efficacy of electrochemotherapy in recurrent head and neck cancer.
Methods
Phase II clinical trial in patients with recurrent head and neck carcinomas with no curative treatment options. Electrochemotherapy was performed under general anesthesia. Primary endpoint was tumor response (CT scanning) evaluated at week 8. Secondary endpoints included biopsy results, MRI and fluorodeoxyglucose‐positron emission tomography scanning, safety, toxicity, pain score, and quality‐of‐life questionnaires.
Results
Of 26 patients treated, 5 (19%) achieved complete response, 10 (39%) partial response, resulting in an objective response of 58%. Two responders remain without recurrence. No serious adverse events occurred during treatment. Four events occurred posttreatment: one bleeding episode, two episodes with mucosal swelling, and one patient died due to disease progression.
Conclusion
Electrochemotherapy is efficient against local recurrence of head and neck cancer with an overall response rate of 58%.
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Regression of human immunodeficiency virus‐associated oral Kaposi sarcoma with combined antiretroviral therapy: A case report and literature review
Abstract
Background
Kaposi's sarcoma (KS) is the most prevalent malignant neoplasia in human immunodeficiency virus positive (HIV+) patients for which the primary mode of management was chemotherapy.
Methods
We have presented the case of a newly diagnosed HIV+ male patient who was diagnosed with a pedunculated nodule in the anterior region of the hard palate, measuring 3.5 cm in diameter and with 2 months of evolution.
Results
Histopathological examination confirmed the clinical hypothesis of KS. Soon after the diagnosis, the patient started using combined antiretroviral therapy (Biovir and Kaletra), presenting a significant reduction of the lesion after 4 weeks. With 1.5 cm in diameter, the lesion was surgically removed. The patient was followed‐up for 10 years without any recurrence.
Conclusion
In antiretroviral‐naive patients with a well‐preserved immune system, the use of cART may be efficient in reducing the progression of the KS lesions, thus avoiding the use of chemotherapeutic agents.
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Three prognostic indexes as predictors of response to adjuvant chemoradiotherapy in patients with oral squamous cell carcinoma after radical surgery: A large‐scale prospective study
Abstract
Background
To develop and validate practical prognostic indexes (PIs) for predicting the prognosis and response to postoperative adjuvant therapy in patients with oral squamous cell carcinoma (OSCC).
Methods
A large cohort of 1071 OSCC patients were randomized to either training set (N = 708) or validation set (N = 363). Three types of PIs were developed according to the nomogram scores, β coefficients and excess hazard ratios, respectively. Restricted cubic spline was used to demonstrate the relationship between PIs and the risks of death.
Results
First, a nomogram was developed incorporating age at diagnosis, smoking status, clinical stage, tumor differentiation, lymph node status, comorbidity, and neutrophil to lymphocyte ratio levels. Then, three PIs were established with high survival predictive ability, and were superior to AJCC staging system (all P < .05). The risks of death were escalated continuously with the increasing number of PIs. Interestingly, adjuvant chemoradiotherapy was positively associated with poor overall survival in patients with low PIs, but exerted a beneficial effect on patients with high PIs.
Conclusion
Combined nomogram with further established PIs not only predicts the survival probability of OSCC patients, but also continuously quantifies the risk of death. High PIs could predict a beneficial response to adjuvant chemoradiotherapy, whereas low PIs indicate an unfavorable response.
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Radiographic nodal prognostic factors in stage I HPV‐related oropharyngeal squamous cell carcinoma
Abstract
Background
The updated AJCC Cancer Staging Manual groups all p16‐positive oropharyngeal squamous cell carcinoma (OPSCC) with unilateral nodal involvement within 6 cm into the new clinical N1 classification, consolidating a heterogeneous group of disease with varying radiographic findings.
Methods
A central radiological review was conducted identifying 233 patients with stage I node‐positive (cT1‐2N1) disease who underwent definitive concurrent chemoradiation. Factors evaluated included lymph node size, low‐neck lymphadenopathy, retropharyngeal lymphadenopathy, overt radiographic extracapsular extension, and matted lymphadenopathy.
Results
On multivariate analysis adjusted for age, smoking history, and chemotherapy regimen, low‐neck lymphadenopathy (hazard ratio (HR) = 6.55; P < .001) and retropharyngeal lymphadenopathy (HR = 3.36; P = .009) predicted for inferior progression‐free survival (PFS). low‐neck lymphadenopathy (HR = 6.38; P = .001) and retropharyngeal lymphadenopathy (HR = 3.32; P = .02) also predicted for inferior overall survival (OS). All other radiographic characteristics showed no prognostic impact for PFS or OS.
Conclusions
This analysis suggests that caution should be advised against de‐intensification efforts among patients with stage I node‐positive p16‐positive OPSCC with low‐neck lymphadenopathy or retropharyngeal lymphadenopathy.
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Smoking and papillomavirus DNA in patients with p16‐positive N3 oropharyngeal squamous cell carcinoma
Abstract
Background
We investigated the survival of patients with a p16‐positive N3 oropharyngeal squamous cell carcinoma (OPSCC) and the prognostic significance of patient, tumor, and treatment characteristics.
Methods
We retrospectively reviewed the data of patients treated at our Cancer Center for a p16‐positive N3 OPSCC between 2003 and 2016. End points were overall survival (OS) and progression‐free survival (PFS).
Results
A total of 29 patients were included. The 5‐year OS and PFS were 67.5% and 59.1%, respectively. Smoking history above 10 pack‐years and the absence of human papillomavirus DNA were associated with worse OS (P = .02 and P = .03, respectively) and PFS (P = .02 and P = .02, respectively). Induction chemotherapy or radical neck dissection were not associated with different treatment outcomes.
Conclusion
Patients with an N3 p16‐positive oropharyngeal cancer in our series had a 5‐year OS rate of 67.5%. Smoking history and viral DNA were prognostic factors associated with survival.
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Influence of comorbidity on therapeutic decision making and impact on outcomes in patients with head and neck squamous cell cancers: Results from a prospective cohort study
Abstract
Background
High prevalence of comorbidity in head and neck squamous cell carcinoma (HNSCC) often lead to suboptimal treatment. The presence study aims to evaluate the presence of comorbidity, its impact on therapeutic decision making, treatment compliance, and overall survival in HNSCC.
Methods
Five hundred eighteen patients with nonmetastatic HNSCC, elder than 18 years of age, without any prior history of cancer or anticancer treatment in the last 5 years were evaluated using Adult Comorbidity Evaluation 27 (ACE 27) index.
Results
Two hundred ninety three (56.6%) patients had comorbidity, and 20.6% had deviation from the ideal treatment plan. Higher grade of comorbidity led to less likely completion of guideline‐concordant therapy (moderate ACE 27 vs none: odds ratio [OR] 0.46, 95% confidence interval [CI] 0.26‐0.82, P < .01*; severe ACE 27 vs none: OR 0.23, 95% CI 0.08‐0.57, P < .01*). Patients who completed guideline‐concordant treatment had the best outcomes as compared to those who could not (median survival: not reached vs 9.56 months, hazard ratio 3.66, 95% CI: 2.8‐4.79; P < .01*).
Conclusion
Presence of increasing severity of comorbidity in HNSCC influences therapeutic decision making. Survival outcomes are poorer in patients receiving guideline‐discordant treatment.
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Masticatory function and related factors after oral oncological treatment: a 5‐year prospective study
Abstract
Background
Chewing ability is often compromised in patients with oral cancer. The aim of this study was to identify which factors affect masticatory performance in these patients.
Methods
Patients with primary oral cancer were assessed for up to 5 years after primary treatment. Healthy controls were assessed once. A mixed‐model analysis was performed, with masticatory performance as outcome measure.
Results
A total of 123 patients were included in the study. Factors positively associated with masticatory performance were number of occlusal units (OU), having functional dentures, and maximum mouth opening (MMO). The impact of tumor location and maximum bite force (MBF) differed per assessment moment. Masticatory performance declined for up to 1 year but recovered at 5 years after treatment.
Conclusion
Masticatory performance in patients treated for oral cancer is affected by MBF, MMO, number of OU, and dental status. These should be the focus of posttreatment therapy.
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Prospective instrumental evaluation of swallowing, tongue function, and QOL measures following transoral robotic surgery alone without adjuvant therapy
Abstract
Background
Transoral robotic surgery (TORS) has been utilized to deintensify treatment. No studies have measured swallow safety and efficiency, nor assessed the functional impact of TORS alone.
Methods
This prospective cohort underwent baseline and 1‐month postsurgery assessments including modified barium swallow evaluation, using the Dynamic Imaging Grade of Swallowing Toxicity (DIGEST) rating system, tongue range of motion assessment, the Performance Status Scale (PSS), and quality of life with the MD Anderson Dysphagia Inventory (MDADI).
Results
All DIGEST safety scores were 0 (normal) at both time points. DIGEST efficiency scores were mildly impaired in 2 of 10 patients postsurgery. PSS scores revealed all patients were on regular diets, were 100% understandable, and were eating in public at both time points. Tongue Range of Motion scores were 100 of 100 at both time points. MDADI scores were not significantly different across time points.
Conclusions
Careful identification of patients can result in excellent outcomes following TORS. Future studies will examine longer follow‐up of speech, swallowing, and tongue function in patients undergoing TORS surgery.
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Prognostic value of C‐reactive protein/albumin ratio for patients with hypopharyngeal and laryngeal cancer undergoing invasive surgery involving laryngectomy
Abstract
Background
The C‐reactive protein/albumin (CRP/Alb) ratio has been recently established as a prognostic indicator in various cancer types. However, few reports regarding the prognostic value of the CRP/Alb ratio in head and neck cancer exist. This study aimed to investigate the significance of the CRP/Alb ratio in clinical outcomes after invasive surgery involving laryngectomy for hypopharyngeal and laryngeal cancer.
Methods
We evaluated 56 patients who underwent total laryngectomy or total pharyngolaryngectomy between 2003 and 2012. Univariate and multivariate analyses were retrospectively performed to examine the prognostic value of the CRP/Alb ratio in these patients.
Results
The optimal cutoff value of the CRP/Alb ratio was 0.32. Multivariate analysis showed that the CRP/Alb ratio was a significant and independent predictor of poor overall and disease‐free survival.
Conclusion
The CRP/Alb ratio may be a novel and useful indicator for predicting postoperative outcomes in patients with hypopharyngeal and laryngeal cancer.
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Expression of CD44, EGFR, p16, and their mutual combinations in patients with head and neck cancer: Impact on outcomes of intensity‐modulated radiation therapy
Abstract
Background
Progress in radiation treatment of head and neck squamous cell carcinoma (HNSCC) deserves the studies focused on molecular predictors that would help to enhance individually tailored treatment.
Methods
p16/epidermal growth factor receptor (EGFR)/cluster of differentiation‐44 (CD44) was immunohistochemically analyzed in 165 HNSCC patients.
Results
In the entire group and the p16 negative cohort, better 3‐year overall survival and locoregional control correlated with p16 positivity, CD44, and EGFR negativity were observed. Combined analysis revealed the worst results in the CD44+/p16−, EGFR+/p16−, and EGFR+/CD44+ groups and in the EGFR+/CD44+ within p16 negative cohort. Multivariate analysis found tumor stage, Karnofsky index, p16, and CD44 as prognostic factors of overall survival and clinical stage, and p16 as a prognostic factor for locoregional control. Clinical stage and Karnofsky index affected overall survival and tumor stage. EGFR affected locoregional control in the p16 negative subgroup.
Conclusion
Our study confirmed the negative effect of CD44 and EGFR and the positive effect of p16 on radiotherapy results.
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Smoking and papillomavirus DNA in patients with p16‐positive N3 oropharyngeal squamous cell carcinoma
Abstract
Background
We investigated the survival of patients with a p16‐positive N3 oropharyngeal squamous cell carcinoma (OPSCC) and the prognostic significance of patient, tumor, and treatment characteristics.
Methods
We retrospectively reviewed the data of patients treated at our Cancer Center for a p16‐positive N3 OPSCC between 2003 and 2016. End points were overall survival (OS) and progression‐free survival (PFS).
Results
A total of 29 patients were included. The 5‐year OS and PFS were 67.5% and 59.1%, respectively. Smoking history above 10 pack‐years and the absence of human papillomavirus DNA were associated with worse OS (P = .02 and P = .03, respectively) and PFS (P = .02 and P = .02, respectively). Induction chemotherapy or radical neck dissection were not associated with different treatment outcomes.
Conclusion
Patients with an N3 p16‐positive oropharyngeal cancer in our series had a 5‐year OS rate of 67.5%. Smoking history and viral DNA were prognostic factors associated with survival.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2S5oMOX
Radiographic nodal prognostic factors in stage I HPV‐related oropharyngeal squamous cell carcinoma
Abstract
Background
The updated AJCC Cancer Staging Manual groups all p16‐positive oropharyngeal squamous cell carcinoma (OPSCC) with unilateral nodal involvement within 6 cm into the new clinical N1 classification, consolidating a heterogeneous group of disease with varying radiographic findings.
Methods
A central radiological review was conducted identifying 233 patients with stage I node‐positive (cT1‐2N1) disease who underwent definitive concurrent chemoradiation. Factors evaluated included lymph node size, low‐neck lymphadenopathy, retropharyngeal lymphadenopathy, overt radiographic extracapsular extension, and matted lymphadenopathy.
Results
On multivariate analysis adjusted for age, smoking history, and chemotherapy regimen, low‐neck lymphadenopathy (hazard ratio (HR) = 6.55; P < .001) and retropharyngeal lymphadenopathy (HR = 3.36; P = .009) predicted for inferior progression‐free survival (PFS). low‐neck lymphadenopathy (HR = 6.38; P = .001) and retropharyngeal lymphadenopathy (HR = 3.32; P = .02) also predicted for inferior overall survival (OS). All other radiographic characteristics showed no prognostic impact for PFS or OS.
Conclusions
This analysis suggests that caution should be advised against de‐intensification efforts among patients with stage I node‐positive p16‐positive OPSCC with low‐neck lymphadenopathy or retropharyngeal lymphadenopathy.
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Regression of human immunodeficiency virus‐associated oral Kaposi sarcoma with combined antiretroviral therapy: A case report and literature review
Abstract
Background
Kaposi's sarcoma (KS) is the most prevalent malignant neoplasia in human immunodeficiency virus positive (HIV+) patients for which the primary mode of management was chemotherapy.
Methods
We have presented the case of a newly diagnosed HIV+ male patient who was diagnosed with a pedunculated nodule in the anterior region of the hard palate, measuring 3.5 cm in diameter and with 2 months of evolution.
Results
Histopathological examination confirmed the clinical hypothesis of KS. Soon after the diagnosis, the patient started using combined antiretroviral therapy (Biovir and Kaletra), presenting a significant reduction of the lesion after 4 weeks. With 1.5 cm in diameter, the lesion was surgically removed. The patient was followed‐up for 10 years without any recurrence.
Conclusion
In antiretroviral‐naive patients with a well‐preserved immune system, the use of cART may be efficient in reducing the progression of the KS lesions, thus avoiding the use of chemotherapeutic agents.
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Definitive RT + cisplatin or cetuximab in head and neck cancer | Cancer - MD Linx
Definitive RT + cisplatin or cetuximab in head and neck cancer | Cancer MD Linx
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Ep1HTl
Otolaryngology Article: Survival of patients with head and neck cancer treated with definitive radiotherapy and concurrent cisplatin or concurrent cetuximab: A ...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Ep1HTl
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