Depth of invasion alone as a prognostic factor in low‐risk early‐stage oral cavity carcinoma

Objectives

To evaluate the significance of increasing depth of invasion (DOI) as the sole risk factor for recurrence in patients with low‐risk early‐stage oral cavity squamous cell carcinoma (OCSCC).

Methods

We retrospectively reviewed 560 patients with OCSCC treated at our institution between 2003 and 2013. Patients were included if they had low‐risk early‐stage OCSCC treated with surgical resection ± neck dissection and no adjuvant therapy. Low risk was defined as absence of positive or close margins, lymphovascular invasion, perineural invasion, and positive lymph nodes. Patients with tumor (T)3‐T4 disease were excluded. Pathology specimens were independently re‐reviewed by two board‐certified pathologists to confirm proper measurement of DOI. Kaplan‐Meier and Cox proportional hazards regression analyses were performed to identify factors predictive for recurrence as well as progression‐free survival (PFS) and overall survival (OS).

Results

A total of 126 patients with low‐risk early‐stage T1‐2N0 OCSCC were included. Median follow‐up time was 42.5 months and median DOI was 4 mm. There was no significant difference in incidence of local (P = 0.95), regional (P = 0.81), or distant recurrence (P = 0.96) among patients with DOI < 4 mm versus ≥4 mm. On multivariable analysis, DOI was significant for both PFS (P = 0.03) and OS (P = 0.002).

Conclusion

In this study, we show that in the absence of other high‐risk pathologic features, DOI ≥ 4 mm does not portend for increased incidence of local, regional, or distant relapse in patients treated with surgery alone; however, increasing DOI is a marker for worse PFS and OS in patients with low‐risk, early‐stage OCSCC.

Level of Evidence

4. Laryngoscope, 2019

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2F31KFR

Mandibular muscle attachments in genial advancement surgery for obstructive sleep apnea

Objectives/Hypothesis

Genioglossus advancement is performed in select patients with obstructive sleep apnea. Surgical techniques attempt to capture the genial tubercle of the mandible; however, measurements of the genioglossus, geniohyoid, and digastric muscles are poorly delineated. This investigation is the largest anatomic study exploring the muscles of genial advancement surgery and the first to quantitatively characterize muscular attachments relative to the tubercle, providing new insights from an anatomic perspective on optimizing muscular advancement.

Study Design

Cadaveric study.

Methods

Fifty‐three fresh cadaveric mandibles underwent dissection of the genial tubercle and genioglossus, geniohyoid, and digastric muscles.

Results

Genial tubercle, geniohyoid, and genioglossus mean height was 7.78 mm, 5.15 mm, and 6.11 mm, respectively. On average, the geniohyoid began 4.88 mm and ended 10.03 mm from the inferior border of the mandible; the genioglossus 11.91 mm and 18.01 mm, similarly. Intermuscular distance, if present, was 2.67 mm; the muscles overlapped in 28% of cadavers. The combined vertical height of the muscles at their mandibular attachment was 13.94 mm, significantly differing from the height of the genial tubercle. The left and right lateral insertion of the digastric muscles was 19.34 mm and 19.31 mm, respectively, from midline.

Conclusions

The variable range of muscle attachments suggests that genioglossal and geniohyoid attachments extend beyond the genial tubercle and may not originate concentrically from the tubercle, but overlap and lie in very close proximity. Mandibular anterior muscle attachments require anatomic accuracy and an effective operative evaluation of advancement before reproducible, clinically effective osteotomies can be recommended.

Level of Evidence

NA Laryngoscope, 2019

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2F9pmYH

Comparing short‐term outcomes of surgery and voice therapy for patients with vocal fold polyps

Objectives/Hypothesis

Optimal treatment for patients with vocal fold polyps (VFPs) remains controversial. We compared the short‐term outcomes of treatment with voice therapy alone (VT), surgery alone (SUR)m or voice therapy and surgery (VTS).

Study Design

Retrospective case series.

Methods

A retrospective study was performed for patients diagnosed with VFP (International Classification of Diseases, Ninth Revision code 478.4 and Tenth Revision code J38.1) between January 2010 and April 2016. Inclusion criteria were age greater than 18 years and charted evidence of treatment with voice therapy, surgery, or both. Exclusion criteria were history of laryngeal cancer or radiation above the clavicles. Outcomes measured included chart records of lesion absence, persistence or recurrence, and differences between pretreatment and post‐treatment Voice Handicap Index‐10 and GRBAS (G/grade, R/roughness, B/breathiness, A/asthenia, S/strain) scores.

Results

One hundred twenty patients with VFPs were identified (SUR = 23, 19.2%, VT = 29, 24.2%, VTS = 68, 56.7%). Mean follow‐up was 5.5 months. There were no recurrences in 115 patients (95.8%). There was significant improvement from pre‐ to post‐treatment VHI‐10 scores in the SUR (mean improvement = 12.5, standard deviation [SD] = 12.7) and VTS (mean improvement = 12.3, SD = 10.3) groups compared to the VT (mean improvement = 2.84, SD = 11.9) group (P = .009). Pre‐ and post‐treatment GRBAS scores did not significantly change in any group.

Conclusions

When using patient‐reported outcomes measures, patients with VFPs receive the greatest short‐term gains from treatment paradigms involving surgery or a combination of surgery and voice therapy. Voice therapy alone did not result in significant short‐term changes. Perceptual voice characteristics did not change significantly for any group. Further research on long‐term treatment outcomes for patients with VFPs is needed.

Level of Evidence

3 Laryngoscope, 2019

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2F4c28w

Depth of invasion alone as a prognostic factor in low‐risk early‐stage oral cavity carcinoma

Objectives

To evaluate the significance of increasing depth of invasion (DOI) as the sole risk factor for recurrence in patients with low‐risk early‐stage oral cavity squamous cell carcinoma (OCSCC).

Methods

We retrospectively reviewed 560 patients with OCSCC treated at our institution between 2003 and 2013. Patients were included if they had low‐risk early‐stage OCSCC treated with surgical resection ± neck dissection and no adjuvant therapy. Low risk was defined as absence of positive or close margins, lymphovascular invasion, perineural invasion, and positive lymph nodes. Patients with tumor (T)3‐T4 disease were excluded. Pathology specimens were independently re‐reviewed by two board‐certified pathologists to confirm proper measurement of DOI. Kaplan‐Meier and Cox proportional hazards regression analyses were performed to identify factors predictive for recurrence as well as progression‐free survival (PFS) and overall survival (OS).

Results

A total of 126 patients with low‐risk early‐stage T1‐2N0 OCSCC were included. Median follow‐up time was 42.5 months and median DOI was 4 mm. There was no significant difference in incidence of local (P = 0.95), regional (P = 0.81), or distant recurrence (P = 0.96) among patients with DOI < 4 mm versus ≥4 mm. On multivariable analysis, DOI was significant for both PFS (P = 0.03) and OS (P = 0.002).

Conclusion

In this study, we show that in the absence of other high‐risk pathologic features, DOI ≥ 4 mm does not portend for increased incidence of local, regional, or distant relapse in patients treated with surgery alone; however, increasing DOI is a marker for worse PFS and OS in patients with low‐risk, early‐stage OCSCC.

Level of Evidence

4. Laryngoscope, 2019

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2F31KFR

Mandibular muscle attachments in genial advancement surgery for obstructive sleep apnea

Objectives/Hypothesis

Genioglossus advancement is performed in select patients with obstructive sleep apnea. Surgical techniques attempt to capture the genial tubercle of the mandible; however, measurements of the genioglossus, geniohyoid, and digastric muscles are poorly delineated. This investigation is the largest anatomic study exploring the muscles of genial advancement surgery and the first to quantitatively characterize muscular attachments relative to the tubercle, providing new insights from an anatomic perspective on optimizing muscular advancement.

Study Design

Cadaveric study.

Methods

Fifty‐three fresh cadaveric mandibles underwent dissection of the genial tubercle and genioglossus, geniohyoid, and digastric muscles.

Results

Genial tubercle, geniohyoid, and genioglossus mean height was 7.78 mm, 5.15 mm, and 6.11 mm, respectively. On average, the geniohyoid began 4.88 mm and ended 10.03 mm from the inferior border of the mandible; the genioglossus 11.91 mm and 18.01 mm, similarly. Intermuscular distance, if present, was 2.67 mm; the muscles overlapped in 28% of cadavers. The combined vertical height of the muscles at their mandibular attachment was 13.94 mm, significantly differing from the height of the genial tubercle. The left and right lateral insertion of the digastric muscles was 19.34 mm and 19.31 mm, respectively, from midline.

Conclusions

The variable range of muscle attachments suggests that genioglossal and geniohyoid attachments extend beyond the genial tubercle and may not originate concentrically from the tubercle, but overlap and lie in very close proximity. Mandibular anterior muscle attachments require anatomic accuracy and an effective operative evaluation of advancement before reproducible, clinically effective osteotomies can be recommended.

Level of Evidence

NA Laryngoscope, 2019

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2F9pmYH

Comparing short‐term outcomes of surgery and voice therapy for patients with vocal fold polyps

Objectives/Hypothesis

Optimal treatment for patients with vocal fold polyps (VFPs) remains controversial. We compared the short‐term outcomes of treatment with voice therapy alone (VT), surgery alone (SUR)m or voice therapy and surgery (VTS).

Study Design

Retrospective case series.

Methods

A retrospective study was performed for patients diagnosed with VFP (International Classification of Diseases, Ninth Revision code 478.4 and Tenth Revision code J38.1) between January 2010 and April 2016. Inclusion criteria were age greater than 18 years and charted evidence of treatment with voice therapy, surgery, or both. Exclusion criteria were history of laryngeal cancer or radiation above the clavicles. Outcomes measured included chart records of lesion absence, persistence or recurrence, and differences between pretreatment and post‐treatment Voice Handicap Index‐10 and GRBAS (G/grade, R/roughness, B/breathiness, A/asthenia, S/strain) scores.

Results

One hundred twenty patients with VFPs were identified (SUR = 23, 19.2%, VT = 29, 24.2%, VTS = 68, 56.7%). Mean follow‐up was 5.5 months. There were no recurrences in 115 patients (95.8%). There was significant improvement from pre‐ to post‐treatment VHI‐10 scores in the SUR (mean improvement = 12.5, standard deviation [SD] = 12.7) and VTS (mean improvement = 12.3, SD = 10.3) groups compared to the VT (mean improvement = 2.84, SD = 11.9) group (P = .009). Pre‐ and post‐treatment GRBAS scores did not significantly change in any group.

Conclusions

When using patient‐reported outcomes measures, patients with VFPs receive the greatest short‐term gains from treatment paradigms involving surgery or a combination of surgery and voice therapy. Voice therapy alone did not result in significant short‐term changes. Perceptual voice characteristics did not change significantly for any group. Further research on long‐term treatment outcomes for patients with VFPs is needed.

Level of Evidence

3 Laryngoscope, 2019

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2F4c28w

Preoperative assessment of simple and complex anorectal fistulas: Tridimensional endoanal ultrasound? Magnetic resonance? Both?

Abstract

Purpose

The purpose of the study is to evaluate the diagnostic value of tridimensional endoanal ultrasound (3D-EAUS) and magnetic resonance (MR) in the preoperative assessment of both simple and complex anorectal fistulas.

Methods

All the patients referred for the treatment of anal fistulas were enrolled in this study and underwent, as preoperative assessment, anamnestic evaluation, clinical examination, and unenhanced and H2O2-enhanced 3D-EAUS and MR. The results of imaging evaluation were compared with surgical findings, considered as reference standard.

Results

During the study period, 124 patients operated on for anal fistulas underwent complete preoperative imaging assessment. Perfect agreement between 3D-EAUS and surgery in the anal fistulas' severity grading was found (K = 1). The fistulas were classified as simple in 68/126 (53.9%) and complex in 58/126 (46.03%) cases, according to fistulas' Parks' classification and the most recent American Guidelines. In both simple and complex anal fistulas, 3D-EAUS did not show a significantly higher accuracy in the evaluation of internal openings, if compared with MR (P = 0.47; McNemar's Chi-square test). In the complex anal fistulas, MR showed a significantly higher accuracy in the evaluation of secondary extensions if compared with 3D-EAUS (P = 0.041; McNemar's Chi-square test), whereas in the simple anal fistulas, no significant difference was found.

Conclusion

In the preoperative work-up of patients with anorectal fistulas, 3D-EAUS may represent the first-line diagnostic tool. In cases of fistulas classified as complex by 3D-EAUS, MR may be indicated as adjunctive diagnostic imaging examination, to more carefully describe the fistulas' complete anatomy.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2BVYY0V

Machine learning-based radiomic models to predict intensity-modulated radiation therapy response, Gleason score and stage in prostate cancer

Abstract

Objective

To develop different radiomic models based on the magnetic resonance imaging (MRI) radiomic features and machine learning methods to predict early intensity-modulated radiation therapy (IMRT) response, Gleason scores (GS) and prostate cancer (Pca) stages.

Methods

Thirty-three Pca patients were included. All patients underwent pre- and post-IMRT T2-weighted (T2 W) and apparent diffusing coefficient (ADC) MRI. IMRT response was calculated in terms of changes in the ADC value, and patients were divided as responders and non-responders. A wide range of radiomic features from different feature sets were extracted from all T2 W and ADC images. Univariate radiomic analysis was performed to find highly correlated radiomic features with IMRT response, and a paired t test was used to find significant features between responders and non-responders. To find high predictive radiomic models, tenfold cross-validation as the criterion for feature selection and classification was applied on the pre-, post- and delta IMRT radiomic features, and area under the curve (AUC) of receiver operating characteristics was calculated as model performance value.

Results

Of 33 patients, 15 patients (45%) were found as responders. Univariate analysis showed 20 highly correlated radiomic features with IMRT response (20 ADC and 20 T2). Two and fifteen T2 and ADC radiomic features were found as significant (P-value ≤ 0.05) features between responders and non-responders, respectively. Several cross-combined predictive radiomic models were obtained, and post-T2 radiomic models were found as high predictive models (AUC 0.632) followed by pre-ADC (AUC 0.626) and pre-T2 (AUC 0.61). For GS prediction, T2 W radiomic models were found as more predictive (mean AUC 0.739) rather than ADC models (mean AUC 0.70), while for stage prediction, ADC models had higher prediction performance (mean AUC 0.675).

Conclusions

Radiomic models developed by MR image features and machine learning approaches are noninvasive and easy methods for personalized prostate cancer diagnosis and therapy.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2R4HSZe

High-dose intensity-modulated radiation therapy as primary treatment of prostate cancer: genitourinary/gastrointestinal toxicity and outcomes, a single-institution experience

Abstract

Purpose

Prostatectomy, radiotherapy and watchful waiting are the main therapeutic options available for local stage of prostate cancer (PCa). We report our experience on 394 patients affected by prostate cancer primarily treated with high-dose, image-guided, IMRT, focusing on gastrointestinal, genitourinary toxicities and biochemical control.

Methods

From July 2003 to August 2014, 394 patients were treated with radical high-dose radiotherapy (HDRT) for prostate cancer; the mean total radiation dose was 79 Gy in standard fractions. Hormonal therapy (HT) was administered to 7.6% of low-risk patients, to 20.3% of intermediate-risk patients and to 72% of high-risk patients. Patients were evaluated for biochemical failure, local recurrence (LR) and metastases.

Results

Ninety-seven patients (26.65%) developed acute GU toxicity at the medium dose of 25.4 Gy, grade 1 (G1) or grade 2 (G2) in 94 cases. Only 16 patients (4.06%) reported chronic GU toxicity (G1 or G2), and one case developed G3 cystitis. No G3 GI acute and late toxicity were detected. Fifty-six (14.2%) patients experienced LR, 26 (6.6%) developed metastases and 70 patients (17.8%) were deceased. Gleason sum score > 7 was predictive for worse overall survival (GS = 7 was borderline) and for metastasis. No factors resulted predictive for local relapse. HT pre-RT had been demonstrated as a negative predictor for OS and DFS-DM.

Conclusions

Data confirm the safety of HDRT for PCa. Treatment was efficient with low toxicity profile. Moreover, continued technologic advancements, as image-guided radiotherapy, could lead to further reduction in toxicity, thus increasing the therapeutic index.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2BZ4YpX

MRI findings and utility of DWI in the evaluation of solid parathyroid lesions

Abstract

Purpose

To evaluate the MRI findings of solid parathyroid lesions and to elaborate on a possible improvement of MRI detection of parathyroid lesions by the use of additional DWI.

Materials and methods

MRI and DWI properties of pathologically proven 20 solid parathyroid lesions were retrospectively reviewed. Mean ADC values (b50 + b400 + b800/3) of parathyroid lesions were compared with that of normal appearing thyroid parenchyma (TP), sternocleidomastoid muscle (SCM) and jugulodigastric lymph nodes (JDLN).

Results

Of lesions, 4 were parathyroid hyperplasia, 13 parathyroid adenoma and 3 parathyroid adenocarcinoma. All parathyroid lesions were very bright on fat-saturated T2W images. Parathyroid hyperplasia and adenoma were small sized, homogenous, well-defined and low on T1W, high on T2W and avidly enhancing. Parathyroid carcinoma was large sized, ill-defined and very heterogeneous on MRI including DWI. Means ADC values of parathyroid hyperplasia, adenoma, and adenocarcinoma, TP, SCM and JDLN were measured as 2.3 ± 0.14 × 10⁻³, 1.7 ± 0.45 × 10⁻³, 1.5 ± 1.48 × 10⁻³, 0.87 ± 0.40 × 10⁻³, 0.55 ± 0.21 × 10⁻³ and 0.96 ± 0.33 × 10⁻³ mm²/s, respectively. All parathyroid lesions had high diffusion properties comparing other soft tissue structures of head and neck region. By increasing strength (b value) of diffusion tensor on DWI, solid parathyroid lesions still kept their brightness comparing other soft tissue structures of head and neck region because of their high T2 properties.

Conclusion

Solid parathyroid lesions had higher diffusion properties comparing other soft tissues structures of head and neck region. This feature makes them easily differentiate from nearby structures on fat-saturated T2W and DWI.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2R9PBp7

Preoperative assessment of simple and complex anorectal fistulas: Tridimensional endoanal ultrasound? Magnetic resonance? Both?

Abstract

Purpose

The purpose of the study is to evaluate the diagnostic value of tridimensional endoanal ultrasound (3D-EAUS) and magnetic resonance (MR) in the preoperative assessment of both simple and complex anorectal fistulas.

Methods

All the patients referred for the treatment of anal fistulas were enrolled in this study and underwent, as preoperative assessment, anamnestic evaluation, clinical examination, and unenhanced and H2O2-enhanced 3D-EAUS and MR. The results of imaging evaluation were compared with surgical findings, considered as reference standard.

Results

During the study period, 124 patients operated on for anal fistulas underwent complete preoperative imaging assessment. Perfect agreement between 3D-EAUS and surgery in the anal fistulas' severity grading was found (K = 1). The fistulas were classified as simple in 68/126 (53.9%) and complex in 58/126 (46.03%) cases, according to fistulas' Parks' classification and the most recent American Guidelines. In both simple and complex anal fistulas, 3D-EAUS did not show a significantly higher accuracy in the evaluation of internal openings, if compared with MR (P = 0.47; McNemar's Chi-square test). In the complex anal fistulas, MR showed a significantly higher accuracy in the evaluation of secondary extensions if compared with 3D-EAUS (P = 0.041; McNemar's Chi-square test), whereas in the simple anal fistulas, no significant difference was found.

Conclusion

In the preoperative work-up of patients with anorectal fistulas, 3D-EAUS may represent the first-line diagnostic tool. In cases of fistulas classified as complex by 3D-EAUS, MR may be indicated as adjunctive diagnostic imaging examination, to more carefully describe the fistulas' complete anatomy.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2BVYY0V

Machine learning-based radiomic models to predict intensity-modulated radiation therapy response, Gleason score and stage in prostate cancer

Abstract

Objective

To develop different radiomic models based on the magnetic resonance imaging (MRI) radiomic features and machine learning methods to predict early intensity-modulated radiation therapy (IMRT) response, Gleason scores (GS) and prostate cancer (Pca) stages.

Methods

Thirty-three Pca patients were included. All patients underwent pre- and post-IMRT T2-weighted (T2 W) and apparent diffusing coefficient (ADC) MRI. IMRT response was calculated in terms of changes in the ADC value, and patients were divided as responders and non-responders. A wide range of radiomic features from different feature sets were extracted from all T2 W and ADC images. Univariate radiomic analysis was performed to find highly correlated radiomic features with IMRT response, and a paired t test was used to find significant features between responders and non-responders. To find high predictive radiomic models, tenfold cross-validation as the criterion for feature selection and classification was applied on the pre-, post- and delta IMRT radiomic features, and area under the curve (AUC) of receiver operating characteristics was calculated as model performance value.

Results

Of 33 patients, 15 patients (45%) were found as responders. Univariate analysis showed 20 highly correlated radiomic features with IMRT response (20 ADC and 20 T2). Two and fifteen T2 and ADC radiomic features were found as significant (P-value ≤ 0.05) features between responders and non-responders, respectively. Several cross-combined predictive radiomic models were obtained, and post-T2 radiomic models were found as high predictive models (AUC 0.632) followed by pre-ADC (AUC 0.626) and pre-T2 (AUC 0.61). For GS prediction, T2 W radiomic models were found as more predictive (mean AUC 0.739) rather than ADC models (mean AUC 0.70), while for stage prediction, ADC models had higher prediction performance (mean AUC 0.675).

Conclusions

Radiomic models developed by MR image features and machine learning approaches are noninvasive and easy methods for personalized prostate cancer diagnosis and therapy.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2R4HSZe

High-dose intensity-modulated radiation therapy as primary treatment of prostate cancer: genitourinary/gastrointestinal toxicity and outcomes, a single-institution experience

Abstract

Purpose

Prostatectomy, radiotherapy and watchful waiting are the main therapeutic options available for local stage of prostate cancer (PCa). We report our experience on 394 patients affected by prostate cancer primarily treated with high-dose, image-guided, IMRT, focusing on gastrointestinal, genitourinary toxicities and biochemical control.

Methods

From July 2003 to August 2014, 394 patients were treated with radical high-dose radiotherapy (HDRT) for prostate cancer; the mean total radiation dose was 79 Gy in standard fractions. Hormonal therapy (HT) was administered to 7.6% of low-risk patients, to 20.3% of intermediate-risk patients and to 72% of high-risk patients. Patients were evaluated for biochemical failure, local recurrence (LR) and metastases.

Results

Ninety-seven patients (26.65%) developed acute GU toxicity at the medium dose of 25.4 Gy, grade 1 (G1) or grade 2 (G2) in 94 cases. Only 16 patients (4.06%) reported chronic GU toxicity (G1 or G2), and one case developed G3 cystitis. No G3 GI acute and late toxicity were detected. Fifty-six (14.2%) patients experienced LR, 26 (6.6%) developed metastases and 70 patients (17.8%) were deceased. Gleason sum score > 7 was predictive for worse overall survival (GS = 7 was borderline) and for metastasis. No factors resulted predictive for local relapse. HT pre-RT had been demonstrated as a negative predictor for OS and DFS-DM.

Conclusions

Data confirm the safety of HDRT for PCa. Treatment was efficient with low toxicity profile. Moreover, continued technologic advancements, as image-guided radiotherapy, could lead to further reduction in toxicity, thus increasing the therapeutic index.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2BZ4YpX

MRI findings and utility of DWI in the evaluation of solid parathyroid lesions

Abstract

Purpose

To evaluate the MRI findings of solid parathyroid lesions and to elaborate on a possible improvement of MRI detection of parathyroid lesions by the use of additional DWI.

Materials and methods

MRI and DWI properties of pathologically proven 20 solid parathyroid lesions were retrospectively reviewed. Mean ADC values (b50 + b400 + b800/3) of parathyroid lesions were compared with that of normal appearing thyroid parenchyma (TP), sternocleidomastoid muscle (SCM) and jugulodigastric lymph nodes (JDLN).

Results

Of lesions, 4 were parathyroid hyperplasia, 13 parathyroid adenoma and 3 parathyroid adenocarcinoma. All parathyroid lesions were very bright on fat-saturated T2W images. Parathyroid hyperplasia and adenoma were small sized, homogenous, well-defined and low on T1W, high on T2W and avidly enhancing. Parathyroid carcinoma was large sized, ill-defined and very heterogeneous on MRI including DWI. Means ADC values of parathyroid hyperplasia, adenoma, and adenocarcinoma, TP, SCM and JDLN were measured as 2.3 ± 0.14 × 10⁻³, 1.7 ± 0.45 × 10⁻³, 1.5 ± 1.48 × 10⁻³, 0.87 ± 0.40 × 10⁻³, 0.55 ± 0.21 × 10⁻³ and 0.96 ± 0.33 × 10⁻³ mm²/s, respectively. All parathyroid lesions had high diffusion properties comparing other soft tissue structures of head and neck region. By increasing strength (b value) of diffusion tensor on DWI, solid parathyroid lesions still kept their brightness comparing other soft tissue structures of head and neck region because of their high T2 properties.

Conclusion

Solid parathyroid lesions had higher diffusion properties comparing other soft tissues structures of head and neck region. This feature makes them easily differentiate from nearby structures on fat-saturated T2W and DWI.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2R9PBp7

Development and dosimetry of 203 Pb/ 212 Pb-labelled PSMA ligands: bringing “the lead” into PSMA-targeted alpha therapy?

Abstract

Purpose

The aims of this study were to develop a prostate-specific membrane antigen (PSMA) ligand for labelling with different radioisotopes of lead and to obtain an approximation of the dosimetry of a simulated ²¹²Pb-based alpha therapy using its ²⁰³Pb imaging analogue.

Methods

Four novel Glu-urea-based ligands containing the chelators p-SCN-Bn-TCMC or DO3AM were synthesized. Affinity and PSMA-specific internalization were studied in C4-2 cells, and biodistribution in C4-2 tumour-bearing mice. The most promising compound, ²⁰³Pb-CA012, was transferred to clinical use. Two patients underwent planar scintigraphy scans at 0.4, 4, 18, 28 and 42 h after injection, together with urine and blood sampling. The time–activity curves of source organs were extrapolated from ²⁰³Pb to ²¹²Pb and the calculated residence times of ²¹²Pb were forwarded to its unstable daughter nuclides. QDOSE and OLINDA were used for dosimetry calculations.

Results

In vitro, all ligands showed low nanomolar binding affinities for PSMA. CA09 and CA012 additionally showed specific ligand-induced internalization of 27.4 ± 2.4 and 15.6 ± 2.1 %ID/10⁶ cells, respectively. The ²⁰³Pb-labelled PSMA ligands were stable in serum for 72 h. In vivo, CA012 showed higher specific uptake in tumours than in other organs, and particularly showed rapid kidney clearance from 5.1 ± 2.5%ID/g at 1 h after injection to 0.9 ± 0.1%ID/g at 24 h. In patients, the estimated effective dose from 250–300 MBq of diagnostic ²⁰³Pb-CA012 was 6–7 mSv. Assuming instant decay of daughter nuclides, the equivalent doses projected from a therapeutic activity of 100 MBq of ²¹²Pb-CA012 were 0.6 Sv_RBE5 to the red marrow, 4.3 Sv_RBE5 to the salivary glands, 4.9 Sv_RBE5 to the kidneys, 0.7 Sv_RBE5 to the liver and 0.2 Sv_RBE5 to other organs; representative tumour lesions averaged 13.2 Sv_RBE5 (where RBE5 is relative biological effectiveness factor 5). Compared to clinical experience with ²¹³Bi-PSMA-617 and ²²⁵Ac-PSMA-617, the projected maximum tolerable dose was about 150 MBq per cycle.

Conclusion

²¹²Pb-CA012 is a promising candidate for PSMA-targeted alpha therapy of prostate cancer. The dosimetry estimate for radiopharmaceuticals decaying with the release of unstable daughter nuclides has some inherent limitations, thus clinical translation should be done cautiously.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2BVhEhs

Head and neck microsurgical reconstruction using the superficial temporal vein for antegrade and retrograde drainage: A clinical case series

Abstract

Background

In head and neck microsurgical reconstruction, previous surgery and past radiation exposure to the neck may adversely affect recipient vessel access in the neck. The superficial temporal vessels can be used to overcome these challenges. The purpose of this article is to demonstrate the viability of using the superficial temporal vein (STV) for a double venous anastomosis, for antegrade and retrograde drainage, in head and neck microvascular free flap transfers.

Methods

An 11-year retrospective chart review was performed of clinical cases of head and neck reconstruction by free tissue transfer, in which the recipient vessels used were the superficial temporal artery (STA) and vein, with the latter providing for dual antegrade and retrograde drainage.

Results

The case series comprised of six patients who underwent free flap reconstruction of craniofacial defects following resection of malignant tumours in five, and due to noma in one. Compromising factors were scarring, radiotherapy, previous surgery and the recipient superficial temporal vein being less than 1 mm in diameter above the parotid. The recipient vessels used were the superficial temporal artery and veins in all cases.

Conclusions

The use of the superficial temporal blood supply for a single arterial supply and a dual antegrade and retrograde venous drainage is a reliable technique for free flaps to the upper two thirds of the head. A double venous anastomosis adds to its dependability.

Level of Evidence: Level IV, therapeutic study.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2QkVVEH

Development and dosimetry of 203 Pb/ 212 Pb-labelled PSMA ligands: bringing “the lead” into PSMA-targeted alpha therapy?

Abstract

Purpose

The aims of this study were to develop a prostate-specific membrane antigen (PSMA) ligand for labelling with different radioisotopes of lead and to obtain an approximation of the dosimetry of a simulated ²¹²Pb-based alpha therapy using its ²⁰³Pb imaging analogue.

Methods

Four novel Glu-urea-based ligands containing the chelators p-SCN-Bn-TCMC or DO3AM were synthesized. Affinity and PSMA-specific internalization were studied in C4-2 cells, and biodistribution in C4-2 tumour-bearing mice. The most promising compound, ²⁰³Pb-CA012, was transferred to clinical use. Two patients underwent planar scintigraphy scans at 0.4, 4, 18, 28 and 42 h after injection, together with urine and blood sampling. The time–activity curves of source organs were extrapolated from ²⁰³Pb to ²¹²Pb and the calculated residence times of ²¹²Pb were forwarded to its unstable daughter nuclides. QDOSE and OLINDA were used for dosimetry calculations.

Results

In vitro, all ligands showed low nanomolar binding affinities for PSMA. CA09 and CA012 additionally showed specific ligand-induced internalization of 27.4 ± 2.4 and 15.6 ± 2.1 %ID/10⁶ cells, respectively. The ²⁰³Pb-labelled PSMA ligands were stable in serum for 72 h. In vivo, CA012 showed higher specific uptake in tumours than in other organs, and particularly showed rapid kidney clearance from 5.1 ± 2.5%ID/g at 1 h after injection to 0.9 ± 0.1%ID/g at 24 h. In patients, the estimated effective dose from 250–300 MBq of diagnostic ²⁰³Pb-CA012 was 6–7 mSv. Assuming instant decay of daughter nuclides, the equivalent doses projected from a therapeutic activity of 100 MBq of ²¹²Pb-CA012 were 0.6 Sv_RBE5 to the red marrow, 4.3 Sv_RBE5 to the salivary glands, 4.9 Sv_RBE5 to the kidneys, 0.7 Sv_RBE5 to the liver and 0.2 Sv_RBE5 to other organs; representative tumour lesions averaged 13.2 Sv_RBE5 (where RBE5 is relative biological effectiveness factor 5). Compared to clinical experience with ²¹³Bi-PSMA-617 and ²²⁵Ac-PSMA-617, the projected maximum tolerable dose was about 150 MBq per cycle.

Conclusion

²¹²Pb-CA012 is a promising candidate for PSMA-targeted alpha therapy of prostate cancer. The dosimetry estimate for radiopharmaceuticals decaying with the release of unstable daughter nuclides has some inherent limitations, thus clinical translation should be done cautiously.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2BVhEhs

Head and neck microsurgical reconstruction using the superficial temporal vein for antegrade and retrograde drainage: A clinical case series

Abstract

Background

In head and neck microsurgical reconstruction, previous surgery and past radiation exposure to the neck may adversely affect recipient vessel access in the neck. The superficial temporal vessels can be used to overcome these challenges. The purpose of this article is to demonstrate the viability of using the superficial temporal vein (STV) for a double venous anastomosis, for antegrade and retrograde drainage, in head and neck microvascular free flap transfers.

Methods

An 11-year retrospective chart review was performed of clinical cases of head and neck reconstruction by free tissue transfer, in which the recipient vessels used were the superficial temporal artery (STA) and vein, with the latter providing for dual antegrade and retrograde drainage.

Results

The case series comprised of six patients who underwent free flap reconstruction of craniofacial defects following resection of malignant tumours in five, and due to noma in one. Compromising factors were scarring, radiotherapy, previous surgery and the recipient superficial temporal vein being less than 1 mm in diameter above the parotid. The recipient vessels used were the superficial temporal artery and veins in all cases.

Conclusions

The use of the superficial temporal blood supply for a single arterial supply and a dual antegrade and retrograde venous drainage is a reliable technique for free flaps to the upper two thirds of the head. A double venous anastomosis adds to its dependability.

Level of Evidence: Level IV, therapeutic study.

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What Does It Mean if a Child Doesn ’ t Respond to Their Name?

Speech-language pathologists working in early intervention often consider a young child's lack of response to their name as a potential sign of autism spectrum disorder (ASD). It can also be an indicator of issues with receptive language skills. Sometimes, the parent reports their child does respond to their name, but you notice otherwise. So we need to dig beyond just asking the parent whether they feel like their child responds to their name. Here's the thing—kids might respond at some times, but not at others. One of the challenges experienced by young kids, especially those with ASD, is generalization of skills. Performing a skill—like responding to their name—in a session is different from doing the same in various locations and with a variety of people. So what should SLPs ...

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2BW4yAv

What Does It Mean if a Child Doesn ’ t Respond to Their Name?

Speech-language pathologists working in early intervention often consider a young child's lack of response to their name as a potential sign of autism spectrum disorder (ASD). It can also be an indicator of issues with receptive language skills. Sometimes, the parent reports their child does respond to their name, but you notice otherwise. So we need to dig beyond just asking the parent whether they feel like their child responds to their name. Here's the thing—kids might respond at some times, but not at others. One of the challenges experienced by young kids, especially those with ASD, is generalization of skills. Performing a skill—like responding to their name—in a session is different from doing the same in various locations and with a variety of people. So what should SLPs ...

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2BW4yAv

Dental malocclusions are not just about small and weak bones: assessing the morphology of the mandible with cross-section analysis and geometric morphometrics

Abstract

Objectives

Dental malocclusions in modern populations would be the result of small and weak jaws developing under low masticatory loads. We assess the validity of this by characterising the external and internal morphology of mandibles affected by class II and III malocclusions and comparing them with those from individuals with different masticatory load patterns.

Materials and methods

CTs from up to 118 individuals exerting intensive, medium and low masticatory loads with harmonic occlusion, and from class II and III individuals, were used to compare their external shape using geometric morphometrics, as well as their internal amount and distribution of cortical bone.

Results

The low-load groups (harmonic, class II and III occlusion) are externally more gracile than the intense and medium load groups. But more relevant in shape variation is a marked allometric pattern, which differentiates class II (small) and III (large) mandibles. Despite gracility, the relative amount of cortical bone in the low-load groups is larger than in the remaining groups.

Conclusions

There is no evidence that the modern mandible, including class II and III individuals, is intrinsically small and weak. Instead, there is a rather large degree of morphological variation, which could be linked to a lack of constraints derived from low masticatory loads. Thus, the effect of other factors such as genetics, but also basal metabolism, should be looked in more depth.

Clinical relevance

Dental malocclusions are a common disorder whose aetiology has not been unravelled, and several to be considered in the prevention and therapy of malocclusion.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2F4Kujp

Dental malocclusions are not just about small and weak bones: assessing the morphology of the mandible with cross-section analysis and geometric morphometrics

Abstract

Objectives

Dental malocclusions in modern populations would be the result of small and weak jaws developing under low masticatory loads. We assess the validity of this by characterising the external and internal morphology of mandibles affected by class II and III malocclusions and comparing them with those from individuals with different masticatory load patterns.

Materials and methods

CTs from up to 118 individuals exerting intensive, medium and low masticatory loads with harmonic occlusion, and from class II and III individuals, were used to compare their external shape using geometric morphometrics, as well as their internal amount and distribution of cortical bone.

Results

The low-load groups (harmonic, class II and III occlusion) are externally more gracile than the intense and medium load groups. But more relevant in shape variation is a marked allometric pattern, which differentiates class II (small) and III (large) mandibles. Despite gracility, the relative amount of cortical bone in the low-load groups is larger than in the remaining groups.

Conclusions

There is no evidence that the modern mandible, including class II and III individuals, is intrinsically small and weak. Instead, there is a rather large degree of morphological variation, which could be linked to a lack of constraints derived from low masticatory loads. Thus, the effect of other factors such as genetics, but also basal metabolism, should be looked in more depth.

Clinical relevance

Dental malocclusions are a common disorder whose aetiology has not been unravelled, and several to be considered in the prevention and therapy of malocclusion.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2F4Kujp

What Does It Mean if a Child Doesn ’ t Respond to Their Name?

Speech-language pathologists working in early intervention often consider a young child's lack of response to their name as a potential sign of autism spectrum disorder (ASD). It can also be an indicator of issues with receptive language skills. Sometimes, the parent reports their child does respond to their name, but you notice otherwise. So we need to dig beyond just asking the parent whether they feel like their child responds to their name. Here's the thing—kids might respond at some times, but not at others. One of the challenges experienced by young kids, especially those with ASD, is generalization of skills. Performing a skill—like responding to their name—in a session is different from doing the same in various locations and with a variety of people. So what should SLPs ...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2BW4yAv

What Does It Mean if a Child Doesn ’ t Respond to Their Name?

Speech-language pathologists working in early intervention often consider a young child's lack of response to their name as a potential sign of autism spectrum disorder (ASD). It can also be an indicator of issues with receptive language skills. Sometimes, the parent reports their child does respond to their name, but you notice otherwise. So we need to dig beyond just asking the parent whether they feel like their child responds to their name. Here's the thing—kids might respond at some times, but not at others. One of the challenges experienced by young kids, especially those with ASD, is generalization of skills. Performing a skill—like responding to their name—in a session is different from doing the same in various locations and with a variety of people. So what should SLPs ...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2BW4yAv

Efficacy and safety of preoperative internal maxillary arterial embolization with gelfoam for nasopharyngeal angiofibroma

Abstract

Purpose

To investigate the efficacy and safety of preoperative internal maxillary arterial embolization with gelfoam particles in patients with nasopharyngeal angiofibroma.

Materials and methods

We retrospectively reviewed a total of 27 consecutive patients with pathologically confirmed nasopharyngeal angiofibroma from August 2006 to September 2018. Of the 27 enrolled patients, 10 patients received surgical excision alone; 17 patients received preoperative internal maxillary arterial embolization followed by surgical excision. Embolic agents were gelfoam particles.

Results

The mean volume of intro-operative blood loss was 385.3 ml in patients with preoperative arterial embolization, which was significantly lower than 1215.0 ml in the patients without preoperative arterial embolization (P < 0.001). The mean surgical time was shorter in patients with preoperative arterial embolization than in the patient without preoperative arterial embolization, but the difference had no statistical significance (205.0 vs 264.5 min, P = 0.064). Neurological complications such as facial palsy or vision loss or hemiplegia were not observed in patients with preoperative arterial embolization.

Conclusion

Internal maxillary artery embolization with gelfoam particles suffices to provide an effective and safe adjuvant procedure for surgical excision of nasopharyngeal angiofibroma.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Qf4KA1

Efficacy and safety of preoperative internal maxillary arterial embolization with gelfoam for nasopharyngeal angiofibroma

Abstract

Purpose

To investigate the efficacy and safety of preoperative internal maxillary arterial embolization with gelfoam particles in patients with nasopharyngeal angiofibroma.

Materials and methods

We retrospectively reviewed a total of 27 consecutive patients with pathologically confirmed nasopharyngeal angiofibroma from August 2006 to September 2018. Of the 27 enrolled patients, 10 patients received surgical excision alone; 17 patients received preoperative internal maxillary arterial embolization followed by surgical excision. Embolic agents were gelfoam particles.

Results

The mean volume of intro-operative blood loss was 385.3 ml in patients with preoperative arterial embolization, which was significantly lower than 1215.0 ml in the patients without preoperative arterial embolization (P < 0.001). The mean surgical time was shorter in patients with preoperative arterial embolization than in the patient without preoperative arterial embolization, but the difference had no statistical significance (205.0 vs 264.5 min, P = 0.064). Neurological complications such as facial palsy or vision loss or hemiplegia were not observed in patients with preoperative arterial embolization.

Conclusion

Internal maxillary artery embolization with gelfoam particles suffices to provide an effective and safe adjuvant procedure for surgical excision of nasopharyngeal angiofibroma.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Qf4KA1

Smoking Habits Do Not Differ for Teens With, Without Asthma

WEDNESDAY, Jan. 2, 2019 -- Smoking habits do not differ for adolescents with asthma or their parents versus those without asthma, according to a letter to the editor published online Dec. 4 in Allergy. Ulrika Hellberg, from the Karolinska Institutet... (Source: Drugs.com - Pharma News)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2ArnVl9

December 2018 Briefing - Allergy

Here are what the editors at HealthDay consider to be the most important developments in Allergy for December 2018. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are... (Source: Drugs.com - Pharma News)

MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SFAznm

Smoking Habits Do Not Differ for Teens With, Without Asthma

WEDNESDAY, Jan. 2, 2019 -- Smoking habits do not differ for adolescents with asthma or their parents versus those without asthma, according to a letter to the editor published online Dec. 4 in Allergy. Ulrika Hellberg, from the Karolinska Institutet... (Source: Drugs.com - Pharma News)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2ArnVl9

December 2018 Briefing - Allergy

Here are what the editors at HealthDay consider to be the most important developments in Allergy for December 2018. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are... (Source: Drugs.com - Pharma News)

MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SFAznm

Smoking Habits Do Not Differ for Teens With, Without Asthma

WEDNESDAY, Jan. 2, 2019 -- Smoking habits do not differ for adolescents with asthma or their parents versus those without asthma, according to a letter to the editor published online Dec. 4 in Allergy. Ulrika Hellberg, from the Karolinska Institutet... (Source: Drugs.com - Pharma News)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2ArnVl9

No Link In Mom-to-Be's Diet, Baby's Allergy Risk

There were no differences in food allergy diagnosis rates between infants born to women who made diet changes during pregnancy and those who did not, researchers have found. (Source: WebMD Health)

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2R79HQK

No Link Between Mom-to-Be's Diet, Baby's Allergy Risk

WEDNESDAY, Jan. 2, 2019 -- Avoiding certain foods during pregnancy does not reduce your child's risk of food allergies, a new analysis shows. For the study, researchers examined data from a 2005 to 2007 survey of 4,900 pregnant women who were part... (Source: Drugs.com - Daily MedNews)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2BVwLY8

December 2018 Briefing - Allergy

Here are what the editors at HealthDay consider to be the most important developments in Allergy for December 2018. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are... (Source: Drugs.com - Pharma News)

MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SFAznm

No Link In Mom-to-Be's Diet, Baby's Allergy Risk

There were no differences in food allergy diagnosis rates between infants born to women who made diet changes during pregnancy and those who did not, researchers have found. (Source: WebMD Health)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2R79HQK

No Link Between Mom-to-Be's Diet, Baby's Allergy Risk

WEDNESDAY, Jan. 2, 2019 -- Avoiding certain foods during pregnancy does not reduce your child's risk of food allergies, a new analysis shows. For the study, researchers examined data from a 2005 to 2007 survey of 4,900 pregnant women who were part... (Source: Drugs.com - Daily MedNews)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2BVwLY8

Smoking Habits Do Not Differ for Teens With, Without Asthma

WEDNESDAY, Jan. 2, 2019 -- Smoking habits do not differ for adolescents with asthma or their parents versus those without asthma, according to a letter to the editor published online Dec. 4 in Allergy. Ulrika Hellberg, from the Karolinska Institutet... (Source: Drugs.com - Pharma News)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2ArnVl9

December 2018 Briefing - Allergy

Here are what the editors at HealthDay consider to be the most important developments in Allergy for December 2018. This roundup includes the latest research news from journal articles, as well as the FDA approvals and regulatory changes that are... (Source: Drugs.com - Pharma News)

MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SFAznm

Effectiveness of a comprehensive oral management protocol for the prevention of severe oral mucositis in patients receiving radiotherapy with or without chemotherapy for oral cancer: a multicentre, phase II, randomized controlled trial

The aim of this phase II, multicentre, randomized controlled trial was to evaluate the effectiveness of a comprehensive oral management protocol for the prevention of severe oral mucositis in patients with oral cancer receiving radiotherapy alone or chemoradiotherapy. In total, 124 patients with oral cancer were enrolled from five institutions. Of these, 37 patients undergoing radiotherapy were randomly divided into an intervention group (n=18) and a control group (n=19). The remaining 87 patients, who were undergoing chemoradiotherapy, were also randomized into an intervention group (n=42) and a control group (n=45). (Source: International Journal of Oral and Maxillofacial Surgery)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2GTZGBy

Oral medicine psychiatric liaison clinic: study of 1202 patients attending over an 18-year period

Patients with orofacial pain and discomfort often suffer from psychiatric disorders. However, few studies involving a large sample have examined the diagnostic results of patients with orofacial pain or discomfort in relation to psychiatric disorders. The purpose of this study was to summarize and clarify the characteristics and demographic data of 1202 patients attending the psychiatric liaison clinic at Aichi Gakuin University Hospital. Psychiatric diagnosis was performed by psychiatrists for all patients, based on the Diagnostic and Statistical Manual of Mental Disorders, fifth edition. (Source: International Journal of Oral and Maxillofacial Surgery)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2RuHYst

Effectiveness of a comprehensive oral management protocol for the prevention of severe oral mucositis in patients receiving radiotherapy with or without chemotherapy for oral cancer: a multicentre, phase II, randomized controlled trial

The aim of this phase II, multicentre, randomized controlled trial was to evaluate the effectiveness of a comprehensive oral management protocol for the prevention of severe oral mucositis in patients with oral cancer receiving radiotherapy alone or chemoradiotherapy. In total, 124 patients with oral cancer were enrolled from five institutions. Of these, 37 patients undergoing radiotherapy were randomly divided into an intervention group (n=18) and a control group (n=19). The remaining 87 patients, who were undergoing chemoradiotherapy, were also randomized into an intervention group (n=42) and a control group (n=45). (Source: International Journal of Oral and Maxillofacial Surgery)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2GTZGBy

Oral medicine psychiatric liaison clinic: study of 1202 patients attending over an 18-year period

Patients with orofacial pain and discomfort often suffer from psychiatric disorders. However, few studies involving a large sample have examined the diagnostic results of patients with orofacial pain or discomfort in relation to psychiatric disorders. The purpose of this study was to summarize and clarify the characteristics and demographic data of 1202 patients attending the psychiatric liaison clinic at Aichi Gakuin University Hospital. Psychiatric diagnosis was performed by psychiatrists for all patients, based on the Diagnostic and Statistical Manual of Mental Disorders, fifth edition. (Source: International Journal of Oral and Maxillofacial Surgery)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2RuHYst

Postoperative Pain and Wound Healing After Coblation-Assisted Barbed Anterior Pharyngoplasty (CABAPh): An Observational Study

AbstractDespite the numerous progresses in the palatal surgery, one of the critical aspect of snoring and OSA surgery is the postoperative pain. Over the last decades several surgical palatal procedures have been proposed. Our aim was to evaluate the tolerability of the coblation-assisted barbed anterior pharyngoplasty (CABAPh) in terms of postoperative pain and wound healing, compared with bipolar assisted barbed anterior pharyngoplasty (BAPh). An observational study on 20 patients with simple snoring was conducted. The outcomes measured to assessing pain were a 10  cm visual analog scale (VAS) and the dose of paracetamol + codeine administrated postoperatively. The wound healing was evaluated using a 3-point scale. The other parameters indicative of both pain and surgical repair wer...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2F7S3Fn

Postoperative Pain and Wound Healing After Coblation-Assisted Barbed Anterior Pharyngoplasty (CABAPh): An Observational Study

AbstractDespite the numerous progresses in the palatal surgery, one of the critical aspect of snoring and OSA surgery is the postoperative pain. Over the last decades several surgical palatal procedures have been proposed. Our aim was to evaluate the tolerability of the coblation-assisted barbed anterior pharyngoplasty (CABAPh) in terms of postoperative pain and wound healing, compared with bipolar assisted barbed anterior pharyngoplasty (BAPh). An observational study on 20 patients with simple snoring was conducted. The outcomes measured to assessing pain were a 10  cm visual analog scale (VAS) and the dose of paracetamol + codeine administrated postoperatively. The wound healing was evaluated using a 3-point scale. The other parameters indicative of both pain and surgical repair wer...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2F7S3Fn

No Link In Mom-to-Be's Diet, Baby's Allergy Risk

There were no differences in food allergy diagnosis rates between infants born to women who made diet changes during pregnancy and those who did not, researchers have found. (Source: WebMD Health)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2R79HQK

No Link Between Mom-to-Be's Diet, Baby's Allergy Risk

WEDNESDAY, Jan. 2, 2019 -- Avoiding certain foods during pregnancy does not reduce your child's risk of food allergies, a new analysis shows. For the study, researchers examined data from a 2005 to 2007 survey of 4,900 pregnant women who were part... (Source: Drugs.com - Daily MedNews)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2BVwLY8

No Link In Mom-to-Be's Diet, Baby's Allergy Risk

There were no differences in food allergy diagnosis rates between infants born to women who made diet changes during pregnancy and those who did not, researchers have found. (Source: WebMD Health)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2R79HQK

No Link Between Mom-to-Be's Diet, Baby's Allergy Risk

WEDNESDAY, Jan. 2, 2019 -- Avoiding certain foods during pregnancy does not reduce your child's risk of food allergies, a new analysis shows. For the study, researchers examined data from a 2005 to 2007 survey of 4,900 pregnant women who were part... (Source: Drugs.com - Daily MedNews)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2BVwLY8

Elizabeth Jaffee, MD: 2018 WebMD Health Hero, Scientist

As a young girl she attended cancer fundraisers. That led to a career in immunology research and ultimately to patents for six cancer vaccines. (Source: WebMD Health)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2To4K2m

Elizabeth Jaffee, MD: 2018 WebMD Health Hero, Scientist

As a young girl she attended cancer fundraisers. That led to a career in immunology research and ultimately to patents for six cancer vaccines. (Source: WebMD Health)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2To4K2m

Effects of water availability and UV radiation on silicon accumulation in the C4 crop proso millet

Photochem. Photobiol. Sci., 2019, Advance Article
DOI: 10.1039/C8PP00517F, Paper

Mateja Grašič, Urša Malovrh, Aleksandra Golob, Katarina Vogel-Mikuš, Alenka Gaberščik
In proso millet, water shortage reduced leaf silicon, calcium, phosphorus, and sulphur levels, and ambient ultraviolet radiation reinforced this effect.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://rsc.li/2CLqwaY

Synthesis and antimicrobial photodynamic effect of methylene blue conjugated carbon nanotubes on E. coli and S. aureus

Photochem. Photobiol. Sci., 2019, Advance Article
DOI: 10.1039/C8PP00369F, Paper

Paramanantham Parasuraman, V. T Anju, SB Sruthil Lal, Alok Sharan, Siddhardha Busi, K. Kaviyarasu, Mohammed Arshad, Turki M. S. Dawoud, Asad Syed
The methylene blue and CNT nanoconjugate effectively produced singlet oxygen via photoactivation using a diode laser. It was employed for aPDT against pathogenic bacteria.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://rsc.li/2F5e3l5

Effects of water availability and UV radiation on silicon accumulation in the C4 crop proso millet

Photochem. Photobiol. Sci., 2019, Advance Article
DOI: 10.1039/C8PP00517F, Paper

Mateja Grašič, Urša Malovrh, Aleksandra Golob, Katarina Vogel-Mikuš, Alenka Gaberščik
In proso millet, water shortage reduced leaf silicon, calcium, phosphorus, and sulphur levels, and ambient ultraviolet radiation reinforced this effect.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://rsc.li/2CLqwaY

Synthesis and antimicrobial photodynamic effect of methylene blue conjugated carbon nanotubes on E. coli and S. aureus

Photochem. Photobiol. Sci., 2019, Advance Article
DOI: 10.1039/C8PP00369F, Paper

Paramanantham Parasuraman, V. T Anju, SB Sruthil Lal, Alok Sharan, Siddhardha Busi, K. Kaviyarasu, Mohammed Arshad, Turki M. S. Dawoud, Asad Syed
The methylene blue and CNT nanoconjugate effectively produced singlet oxygen via photoactivation using a diode laser. It was employed for aPDT against pathogenic bacteria.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://rsc.li/2F5e3l5

Effectiveness of a comprehensive oral management protocol for the prevention of severe oral mucositis in patients receiving radiotherapy with or without chemotherapy for oral cancer: a multicentre, phase II, randomized controlled trial

The aim of this phase II, multicentre, randomized controlled trial was to evaluate the effectiveness of a comprehensive oral management protocol for the prevention of severe oral mucositis in patients with oral cancer receiving radiotherapy alone or chemoradiotherapy. In total, 124 patients with oral cancer were enrolled from five institutions. Of these, 37 patients undergoing radiotherapy were randomly divided into an intervention group (n=18) and a control group (n=19). The remaining 87 patients, who were undergoing chemoradiotherapy, were also randomized into an intervention group (n=42) and a control group (n=45).

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SwD2kb

Effectiveness of a comprehensive oral management protocol for the prevention of severe oral mucositis in patients receiving radiotherapy with or without chemotherapy for oral cancer: a multicentre, phase II, randomized controlled trial

The aim of this phase II, multicentre, randomized controlled trial was to evaluate the effectiveness of a comprehensive oral management protocol for the prevention of severe oral mucositis in patients with oral cancer receiving radiotherapy alone or chemoradiotherapy. In total, 124 patients with oral cancer were enrolled from five institutions. Of these, 37 patients undergoing radiotherapy were randomly divided into an intervention group (n=18) and a control group (n=19). The remaining 87 patients, who were undergoing chemoradiotherapy, were also randomized into an intervention group (n=42) and a control group (n=45).

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Evaluation of Mandible Fractures in Patients with Sickle cell anemia- A Nationwide study

Sickle cell anemia is the most commonly inherited blood disorder in the United States. Despite its prevalence, clinicians know little about the extent of its impact on orofacial manifestations. Methods: All patients with diagnoses of both mandible fracture and sickle cell anemia admitted between 2004 and 2014 were identified using the National Inpatient Sample (NIS). Patient demographics, fracture regions, and complications were characterized by descriptive statistics. Results: 51 out of 48,464 patients admitted for mandible fracture had sickle cell anemia.

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Evaluation of Mandible Fractures in Patients with Sickle cell anemia- A Nationwide study

Sickle cell anemia is the most commonly inherited blood disorder in the United States. Despite its prevalence, clinicians know little about the extent of its impact on orofacial manifestations. Methods: All patients with diagnoses of both mandible fracture and sickle cell anemia admitted between 2004 and 2014 were identified using the National Inpatient Sample (NIS). Patient demographics, fracture regions, and complications were characterized by descriptive statistics. Results: 51 out of 48,464 patients admitted for mandible fracture had sickle cell anemia.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2AtsZFq

Evaluation of Mandible Fractures in Patients with Sickle cell anemia- A Nationwide study

Sickle cell anemia is the most commonly inherited blood disorder in the United States. Despite its prevalence, clinicians know little about the extent of its impact on orofacial manifestations. Methods: All patients with diagnoses of both mandible fracture and sickle cell anemia admitted between 2004 and 2014 were identified using the National Inpatient Sample (NIS). Patient demographics, fracture regions, and complications were characterized by descriptive statistics. Results: 51 out of 48,464 patients admitted for mandible fracture had sickle cell anemia.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2AtsZFq

Evaluation of Mandible Fractures in Patients with Sickle cell anemia- A Nationwide study

Sickle cell anemia is the most commonly inherited blood disorder in the United States. Despite its prevalence, clinicians know little about the extent of its impact on orofacial manifestations. Methods: All patients with diagnoses of both mandible fracture and sickle cell anemia admitted between 2004 and 2014 were identified using the National Inpatient Sample (NIS). Patient demographics, fracture regions, and complications were characterized by descriptive statistics. Results: 51 out of 48,464 patients admitted for mandible fracture had sickle cell anemia.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2AtsZFq

Elizabeth Jaffee, MD: 2018 WebMD Health Hero, Scientist

As a young girl she attended cancer fundraisers. That led to a career in immunology research and ultimately to patents for six cancer vaccines. (Source: WebMD Health)

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3D CT Cinematic Rendering of Mandibular Odontogenic Myxofibroma

Three dimensional (3D) methods for visualizing volumetric computed tomography (CT) data can aid in understanding the extent of a disease process and planning necessary surgical interventions. Recently, a new method of 3D image creation known as cinematic rendering (CR) has been developed that produces photorealistic images from standard CT acquisitions. We describe the CT appearance of a rare tumor type, odontogenic myxofibroma, in the mandible of a 33-year-old woman, and we focus on the potential applications of CR visualizations in this and similar scenarios.

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Comparing the Diagnostic Efficacy of Intraoral Radiography and Cone Beam Computed Tomography Volume Registration in the Detection of Mandibular Alveolar Bone Defects

(1) Compare bone loss detection accuracy with intraoral radiography (IO) and registered cone beam computed tomography (CBCT); (2) assess repeatability with both modalities; (3) determine factors affecting defect detection; (4) determine effect of bucco-lingual bone thickness on defect detection.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2TmKEFO

Elizabeth Jaffee, MD: 2018 WebMD Health Hero, Scientist

As a young girl she attended cancer fundraisers. That led to a career in immunology research and ultimately to patents for six cancer vaccines. (Source: WebMD Health)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2To4K2m

3D CT Cinematic Rendering of Mandibular Odontogenic Myxofibroma

Three dimensional (3D) methods for visualizing volumetric computed tomography (CT) data can aid in understanding the extent of a disease process and planning necessary surgical interventions. Recently, a new method of 3D image creation known as cinematic rendering (CR) has been developed that produces photorealistic images from standard CT acquisitions. We describe the CT appearance of a rare tumor type, odontogenic myxofibroma, in the mandible of a 33-year-old woman, and we focus on the potential applications of CR visualizations in this and similar scenarios.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2CKzW6L

Comparing the Diagnostic Efficacy of Intraoral Radiography and Cone Beam Computed Tomography Volume Registration in the Detection of Mandibular Alveolar Bone Defects

(1) Compare bone loss detection accuracy with intraoral radiography (IO) and registered cone beam computed tomography (CBCT); (2) assess repeatability with both modalities; (3) determine factors affecting defect detection; (4) determine effect of bucco-lingual bone thickness on defect detection.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2TmKEFO

CDC: Top HPV-Associated Cancer Is Now Oropharyngeal

Date: 08/23/18 Source: medscape.com Author: Nick Mulcahy Oropharyngeal squamous cell carcinoma (SCC) is now the most common HPV-associated cancer in the United […]

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2QjPiT0

Five Things To Look Out For In Cancer Research In 2019

Date: 12/28/18 Source: Forbes.com Author: Victoria Forster 2018 was a remarkable year for cancer research, with great strides made in diagnosing […]

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2F2W0eh

Hospitals required to post all prices online beginning January 1

Date: 12/26/18 Source: KATV Author: Associated Press   WASHINGTON (AP) — Medicare will require hospitals to post their standard prices online and make […]

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2BYeKIy

Does the Hebrew Eating Assessment Tool-10 Correlate with Pharyngeal Residue, Penetration and Aspiration on Fiberoptic Endoscopic Examination of Swallowing?

The objective of this study was to translate and validate the EAT-10Heb and to test for a correlation between its score and residue, penetration and aspiration on Fiberoptic Endoscopic Examination of Swallowing (FEES). 136 patients visiting two specialized dysphagia clinics and undergoing FEES between April 2015 and August 2017, filled the EAT-10Heb. 23 patients refilled the EAT-10Heb during a 2-week period following their first visit. FEES were scored for residue (1 point per consistency, maximum 3 points) and penetration and aspiration (1 point for penetration, 2 points for aspiration per consistency, maximum 6 points). 51 healthy volunteers also filled the EAT-10Heb. Internal consistency and test –retest reproducibility were examined for reliability testing. Validity was established b...

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Effects of Low-Frequency Repetitive Transcranial Magnetic Stimulation on Swallowing Function and Quality of Life of Post-stroke Patients

In conclusion, despite positive changes in some aspects of quality of life, rTMS did not enhance the swallowing function when compared conventional dysphagia rehabilitation. Therefore, the application of 1 Hz rTMS should be reconsidered to improve swallowing function in the chronic period . (Source: Dysphagia)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2QjGuMX

CDC: Top HPV-Associated Cancer Is Now Oropharyngeal

Date: 08/23/18 Source: medscape.com Author: Nick Mulcahy Oropharyngeal squamous cell carcinoma (SCC) is now the most common HPV-associated cancer in the United […]

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2QjPiT0

Five Things To Look Out For In Cancer Research In 2019

Date: 12/28/18 Source: Forbes.com Author: Victoria Forster 2018 was a remarkable year for cancer research, with great strides made in diagnosing […]

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2F2W0eh

Hospitals required to post all prices online beginning January 1

Date: 12/26/18 Source: KATV Author: Associated Press   WASHINGTON (AP) — Medicare will require hospitals to post their standard prices online and make […]

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2BYeKIy

Does the Hebrew Eating Assessment Tool-10 Correlate with Pharyngeal Residue, Penetration and Aspiration on Fiberoptic Endoscopic Examination of Swallowing?

The objective of this study was to translate and validate the EAT-10Heb and to test for a correlation between its score and residue, penetration and aspiration on Fiberoptic Endoscopic Examination of Swallowing (FEES). 136 patients visiting two specialized dysphagia clinics and undergoing FEES between April 2015 and August 2017, filled the EAT-10Heb. 23 patients refilled the EAT-10Heb during a 2-week period following their first visit. FEES were scored for residue (1 point per consistency, maximum 3 points) and penetration and aspiration (1 point for penetration, 2 points for aspiration per consistency, maximum 6 points). 51 healthy volunteers also filled the EAT-10Heb. Internal consistency and test –retest reproducibility were examined for reliability testing. Validity was established b...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Vr8QbS

Effects of Low-Frequency Repetitive Transcranial Magnetic Stimulation on Swallowing Function and Quality of Life of Post-stroke Patients

In conclusion, despite positive changes in some aspects of quality of life, rTMS did not enhance the swallowing function when compared conventional dysphagia rehabilitation. Therefore, the application of 1 Hz rTMS should be reconsidered to improve swallowing function in the chronic period . (Source: Dysphagia)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2QjGuMX

CDC: Top HPV-Associated Cancer Is Now Oropharyngeal

Date: 08/23/18 Source: medscape.com Author: Nick Mulcahy Oropharyngeal squamous cell carcinoma (SCC) is now the most common HPV-associated cancer in the United […]

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2QjPiT0

CDC: Top HPV-Associated Cancer Is Now Oropharyngeal

Date: 08/23/18 Source: medscape.com Author: Nick Mulcahy Oropharyngeal squamous cell carcinoma (SCC) is now the most common HPV-associated cancer in the United […]

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2QjPiT0

Woman, 68, who received a lung transplant develops her donor's peanut allergy

A 68-year-old woman in San Diego, California, had a severe allergic reaction to a peanut butter and jam sandwich after she developed the nut allergy of the man whose lung was transplanted into her. (Source: the Mail online | Health)

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2R8JzVt

Woman, 68, who received a lung transplant develops her donor's peanut allergy

A 68-year-old woman in San Diego, California, had a severe allergic reaction to a peanut butter and jam sandwich after she developed the nut allergy of the man whose lung was transplanted into her. (Source: the Mail online | Health)

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2R8JzVt

Five Things To Look Out For In Cancer Research In 2019

Date: 12/28/18 Source: Forbes.com Author: Victoria Forster 2018 was a remarkable year for cancer research, with great strides made in diagnosing […]

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2F2W0eh

Five Things To Look Out For In Cancer Research In 2019

Date: 12/28/18 Source: Forbes.com Author: Victoria Forster 2018 was a remarkable year for cancer research, with great strides made in diagnosing […]

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2F2W0eh

Hospitals required to post all prices online beginning January 1

Date: 12/26/18 Source: KATV Author: Associated Press   WASHINGTON (AP) — Medicare will require hospitals to post their standard prices online and make […]

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2BYeKIy

Woman, 68, who received a lung transplant develops her donor's peanut allergy

A 68-year-old woman in San Diego, California, had a severe allergic reaction to a peanut butter and jam sandwich after she developed the nut allergy of the man whose lung was transplanted into her. (Source: the Mail online | Health)

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2R8JzVt

Hospitals required to post all prices online beginning January 1

Date: 12/26/18 Source: KATV Author: Associated Press   WASHINGTON (AP) — Medicare will require hospitals to post their standard prices online and make […]

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2BYeKIy

Woman, 68, who received a lung transplant develops her donor's peanut allergy

A 68-year-old woman in San Diego, California, had a severe allergic reaction to a peanut butter and jam sandwich after she developed the nut allergy of the man whose lung was transplanted into her. (Source: the Mail online | Health)

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Postoperative Pain and Wound Healing After Coblation-Assisted Barbed Anterior Pharyngoplasty (CABAPh): An Observational Study

Abstract

Despite the numerous progresses in the palatal surgery, one of the critical aspect of snoring and OSA surgery is the postoperative pain. Over the last decades several surgical palatal procedures have been proposed. Our aim was to evaluate the tolerability of the coblation-assisted barbed anterior pharyngoplasty (CABAPh) in terms of postoperative pain and wound healing, compared with bipolar assisted barbed anterior pharyngoplasty (BAPh). An observational study on 20 patients with simple snoring was conducted. The outcomes measured to assessing pain were a 10 cm visual analog scale (VAS) and the dose of paracetamol + codeine administrated postoperatively. The wound healing was evaluated using a 3-point scale. The other parameters indicative of both pain and surgical repair were food intake and weight loss postoperatively. The mean overall pain (VAS scale) was significantly less in the CABAPh group (M 3.7; CI 3.34–4.06) compared with the BAPh (M 4.73; CI 4.28–5.19) with a P = 0.003. The mean wound healing after 4 weeks was significantly less in CABAPh group (M 2.7; CI 3.12–2.28) compared with the BAPh (M 2.1; CI 2.45–1.75) with a P = 0.02. There were no statistically significant difference with regard to food intake (P = 0.09) and weight loss (P = 0.94). The CABAPh was able to achieve a greater pain reduction and a faster wound healing compared with bipolar forceps.

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Phase-locking of irregular guinea pig primary vestibular afferents to high frequency ( > 250 Hz) sound and vibration.

Phase-locking of irregular guinea pig primary vestibular afferents to high frequency (>250 Hz) sound and vibration. Hear Res. 2018 Dec 24;373:59-70 Authors: Curthoys IS, Burgess AM, Goonetilleke SC Abstract Phase-locking of cochlear neurons to sound has been of great value in understanding cochlear transduction. Phase-locking has also been reported previously in irregular vestibular afferents, but detailed information about it is sparse. We measured the phase-locking of guinea pig irregular otolithic neurons and canal neurons (after a semicircular canal dehiscence allowed them to respond) to both sound and vibration stimuli. Irregular vestibular afferents from both otoliths and canals have a range of preferred phase angles which systematically increase as frequenc...

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2F21Z32

Postoperative Pain and Wound Healing After Coblation-Assisted Barbed Anterior Pharyngoplasty (CABAPh): An Observational Study

Abstract

Despite the numerous progresses in the palatal surgery, one of the critical aspect of snoring and OSA surgery is the postoperative pain. Over the last decades several surgical palatal procedures have been proposed. Our aim was to evaluate the tolerability of the coblation-assisted barbed anterior pharyngoplasty (CABAPh) in terms of postoperative pain and wound healing, compared with bipolar assisted barbed anterior pharyngoplasty (BAPh). An observational study on 20 patients with simple snoring was conducted. The outcomes measured to assessing pain were a 10 cm visual analog scale (VAS) and the dose of paracetamol + codeine administrated postoperatively. The wound healing was evaluated using a 3-point scale. The other parameters indicative of both pain and surgical repair were food intake and weight loss postoperatively. The mean overall pain (VAS scale) was significantly less in the CABAPh group (M 3.7; CI 3.34–4.06) compared with the BAPh (M 4.73; CI 4.28–5.19) with a P = 0.003. The mean wound healing after 4 weeks was significantly less in CABAPh group (M 2.7; CI 3.12–2.28) compared with the BAPh (M 2.1; CI 2.45–1.75) with a P = 0.02. There were no statistically significant difference with regard to food intake (P = 0.09) and weight loss (P = 0.94). The CABAPh was able to achieve a greater pain reduction and a faster wound healing compared with bipolar forceps.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SERDda

Phase-locking of irregular guinea pig primary vestibular afferents to high frequency ( > 250 Hz) sound and vibration.

Phase-locking of irregular guinea pig primary vestibular afferents to high frequency (>250 Hz) sound and vibration. Hear Res. 2018 Dec 24;373:59-70 Authors: Curthoys IS, Burgess AM, Goonetilleke SC Abstract Phase-locking of cochlear neurons to sound has been of great value in understanding cochlear transduction. Phase-locking has also been reported previously in irregular vestibular afferents, but detailed information about it is sparse. We measured the phase-locking of guinea pig irregular otolithic neurons and canal neurons (after a semicircular canal dehiscence allowed them to respond) to both sound and vibration stimuli. Irregular vestibular afferents from both otoliths and canals have a range of preferred phase angles which systematically increase as frequenc...

MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2F21Z32

Performance metrics in mastoidectomy training: a systematic review

Abstract

Objective

To investigate validity evidence, and strengths and limitations of performance metrics in mastoidectomy training.

Methods

A systematic review following the PRISMA guidelines. Studies reporting performance metrics in mastoidectomy/temporal bone surgery were included. Data on design, outcomes, and results were extracted by two reviewers. Validity evidence according to Messick's framework and level of evidence were assessed.

Results

The search yielded a total of 1085 studies from the years 1947–2018 and 35 studies were included for full data extraction after abstract and full-text screening. 33 different metrics on mastoidectomy performance were identified and ranked according to the number of reports. Most of the 33 metrics identified had some amount of validity evidence. The metrics with most validity evidence were related to drilling time, volume drilled per time, force applied near vital structures, and volume removed.

Conclusions

This review provides an overview of current metrics of mastoidectomy performance, their validity, strengths and limitations, and identifies the gap in validity evidence of some metrics. Evidence-based metrics can be used for performance assessment in temporal bone surgery and for providing integrated and automated feedback in virtual reality simulation training. The use of such metrics in simulation-based mastoidectomy training can potentially address some of the limitations in current temporal bone skill assessment and ease assessment in repeated practice. However, at present, an automated feedback based on metrics in VR simulation does not have sufficient empirical basis and has not been generally accepted for use in training and certification.

Level of evidence

2a.

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Performance metrics in mastoidectomy training: a systematic review

Abstract

Objective

To investigate validity evidence, and strengths and limitations of performance metrics in mastoidectomy training.

Methods

A systematic review following the PRISMA guidelines. Studies reporting performance metrics in mastoidectomy/temporal bone surgery were included. Data on design, outcomes, and results were extracted by two reviewers. Validity evidence according to Messick's framework and level of evidence were assessed.

Results

The search yielded a total of 1085 studies from the years 1947–2018 and 35 studies were included for full data extraction after abstract and full-text screening. 33 different metrics on mastoidectomy performance were identified and ranked according to the number of reports. Most of the 33 metrics identified had some amount of validity evidence. The metrics with most validity evidence were related to drilling time, volume drilled per time, force applied near vital structures, and volume removed.

Conclusions

This review provides an overview of current metrics of mastoidectomy performance, their validity, strengths and limitations, and identifies the gap in validity evidence of some metrics. Evidence-based metrics can be used for performance assessment in temporal bone surgery and for providing integrated and automated feedback in virtual reality simulation training. The use of such metrics in simulation-based mastoidectomy training can potentially address some of the limitations in current temporal bone skill assessment and ease assessment in repeated practice. However, at present, an automated feedback based on metrics in VR simulation does not have sufficient empirical basis and has not been generally accepted for use in training and certification.

Level of evidence

2a.

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Neurofeedback in Alzheimer's Disease

Condition:   Alzheimer Disease Intervention:   Behavioral: Neurofeedback Sponsors:   Oregon Health and Science University;   National Institutes of Health (NIH);   National Institute on Deafness and Other Communication Disorders (NIDCD) Not yet recruiting (Source: ClinicalTrials.gov)

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Neurofeedback in Alzheimer's Disease

Condition:   Alzheimer Disease Intervention:   Behavioral: Neurofeedback Sponsors:   Oregon Health and Science University;   National Institutes of Health (NIH);   National Institute on Deafness and Other Communication Disorders (NIDCD) Not yet recruiting (Source: ClinicalTrials.gov)

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Nasal patency and otorhinolaryngologic-orofacial features in children

ConclusionsNasal patency was lower in children with restless sleep, rhinitis signs and symptoms, hard palate width reduced and with changes in mastication, deglutition and speech functions. It is also emphasized that most of the children presented signs and symptom of allergic rhinitis.ResumoIntroduçãoA obstrução nasal é um sintoma comum na infância relacionado a rinite e hipertrofia das tonsilas faríngeas. Na presença de obstrução nasal, a patência nasal pode estar reduzida e a respiração nasal ser substituída por respiração oral. Alterações orofaciais e otorrinolaringológicas estão relacionadas a esse modo de respiração. A avaliação objetiva das vias aéreas superiores pode ser obtida através da medida da patência nasal.ObjetivoComparar a patência nasal e carac...

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Telling tales: unlocking the potential of AAC technologies.

Authors: Waller A Abstract Augmentative and alternative communication (AAC) has been transformed by the social media revolution made possible by the emergence of mobile technology. The cumbersome dedicated devices of the 1970s have evolved into a burgeoning AAC app industry. However, the limited use and abandonment of AAC technologies remains high. Unlocking the untapped potential of technology requires a paradigm shift in the design of AAC technologies by building systems that minimize the cognitive load placed on users, adapting to their individual physical and language needs. Telling Tales shares insights and stories of how the combination of user-centred design, interdisciplinary research and the application of intelligent computing is providing a vision of future generations o...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2GTbfJe

Nasal patency and otorhinolaryngologic-orofacial features in children

ConclusionsNasal patency was lower in children with restless sleep, rhinitis signs and symptoms, hard palate width reduced and with changes in mastication, deglutition and speech functions. It is also emphasized that most of the children presented signs and symptom of allergic rhinitis.ResumoIntroduçãoA obstrução nasal é um sintoma comum na infância relacionado a rinite e hipertrofia das tonsilas faríngeas. Na presença de obstrução nasal, a patência nasal pode estar reduzida e a respiração nasal ser substituída por respiração oral. Alterações orofaciais e otorrinolaringológicas estão relacionadas a esse modo de respiração. A avaliação objetiva das vias aéreas superiores pode ser obtida através da medida da patência nasal.ObjetivoComparar a patência nasal e carac...

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2RtSGiV

Telling tales: unlocking the potential of AAC technologies.

Authors: Waller A Abstract Augmentative and alternative communication (AAC) has been transformed by the social media revolution made possible by the emergence of mobile technology. The cumbersome dedicated devices of the 1970s have evolved into a burgeoning AAC app industry. However, the limited use and abandonment of AAC technologies remains high. Unlocking the untapped potential of technology requires a paradigm shift in the design of AAC technologies by building systems that minimize the cognitive load placed on users, adapting to their individual physical and language needs. Telling Tales shares insights and stories of how the combination of user-centred design, interdisciplinary research and the application of intelligent computing is providing a vision of future generations o...

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Recognition of Weld Penetration During K-TIG Welding Based on Acoustic and Visual Sensing

Abstract

In the field of welding process control, on-line monitoring of welding quality based on multi-sensor information fusion has attracted more attention. In order to recognize the penetration state of the Keyhole mode Tungsten Inert Gas welded joint in real time, an acoustic and visual sensing system was established in this paper. The acoustic and visual features that characterize the penetration state of the welded joints in 34 dimensions were extracted and the variation of the acoustic signal and the keyhole geometry were analyzed. In addition, the weighted scoring criterion based on the Fisher distance and the maximum information coefficient (Fisher–MIC) and Support Vector Machine (SVM) model based on cross-validation (CV) are designed as the feature selection method. The feature selection method can evaluate the penetration recognition accuracy of different feature subsets. The experiment results show that the maximum recognition accuracy was 97.1655%, which was performed by the 10-dimension optimal feature subset and the CV–SVM model with particle swarm optimization (PSO–CV–SVM). It is proved that the selected acoustic and visual features can well characterize the penetration state of the welded joints, and the feature selection method and PSO–CV–SVM model have superior performance.

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Recognition of Weld Penetration During K-TIG Welding Based on Acoustic and Visual Sensing

Abstract

In the field of welding process control, on-line monitoring of welding quality based on multi-sensor information fusion has attracted more attention. In order to recognize the penetration state of the Keyhole mode Tungsten Inert Gas welded joint in real time, an acoustic and visual sensing system was established in this paper. The acoustic and visual features that characterize the penetration state of the welded joints in 34 dimensions were extracted and the variation of the acoustic signal and the keyhole geometry were analyzed. In addition, the weighted scoring criterion based on the Fisher distance and the maximum information coefficient (Fisher–MIC) and Support Vector Machine (SVM) model based on cross-validation (CV) are designed as the feature selection method. The feature selection method can evaluate the penetration recognition accuracy of different feature subsets. The experiment results show that the maximum recognition accuracy was 97.1655%, which was performed by the 10-dimension optimal feature subset and the CV–SVM model with particle swarm optimization (PSO–CV–SVM). It is proved that the selected acoustic and visual features can well characterize the penetration state of the welded joints, and the feature selection method and PSO–CV–SVM model have superior performance.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Qk0nU8

The protective effects of whortleberry extract against cisplatin-induced ototoxicity in rats

ConclusionThe results obtained in this study show that whortleberry extract has a protective effect against cisplatin-induced ototoxicity.ResumoIntroduçãoA cisplatina é um dos principais agentes quimioterápicos utilizados para o tratamento de muitos tipos de câncer. No entanto, a ototoxicidade, um dos efeitos colaterais mais graves da cisplatina, restringe seu uso.ObjetivoNosso objetivo foi investigar os efeitos protetores do extrato de uva-do-monte contra a ototoxicidade induzida por cisplatina, avaliar o dano auditivo e histopatológico coclear e medir os parâmetros bioquímicos afetados pelo estresse oxidativo.MétodoForam incluídos no estudo 48 ratos machos após teste de emissão otoacústica evocada por produto de distorção para confirmar que seus níveis de audição eram n...

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2F3bCiQ