Five decades of orofacial cleft management and research in Brazil

Our research team read with interest the article by Best et al.1 regarding short-term surgical missions for the management of orofacial clefts (OFCs) in South America. We congratulate the authors, but wish to make some observations. The authors stated that Chile has the only health system in South America with government-guaranteed access to surgical care for OFCs, and that the other countries on the continent are left to depend on temporary international or national campaigns or short-term surgical missions. (Source: International Journal of Oral and Maxillofacial Surgery)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2A2JjNQ

Fatal iatrogenic vinorelbine poisoning: a case report

The paper describes the case of a 69-year-old man with non-small-cell lung cancer who, owing to a mistake, received intravenously 500 mg of vinorelbine. Within 3 days of intoxication, the bone marrow of the patient was damaged with subsequent pancytopenia that did not respond to treatment. On the fifth day after the poisoning, features of intestinal obstruction appeared. The patient died on the sixth day after the drug overdose. The case presented by us constitutes the first description of a fatal iatrogenic poisoning with this drug. Correspondence to Marcin Zawadzki, MD, PhD, Department of Forensic Medicine, Wroclaw Medical University, Mikulicza-Radeckiego 4, PL 50-345 Wroclaw, Poland Tel: +48 717 841 480; fax: +48 717 575 006; e-mail: marcin.zawadzki@umed.wroc.pl Received June 23, 2018 Accepted September 27, 2018 Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2A1udbq

Five decades of orofacial cleft management and research in Brazil

Our research team read with interest the article by Best et al.1 regarding short-term surgical missions for the management of orofacial clefts (OFCs) in South America. We congratulate the authors, but wish to make some observations. The authors stated that Chile has the only health system in South America with government-guaranteed access to surgical care for OFCs, and that the other countries on the continent are left to depend on temporary international or national campaigns or short-term surgical missions. (Source: International Journal of Oral and Maxillofacial Surgery)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2A2JjNQ

Fatal iatrogenic vinorelbine poisoning: a case report

The paper describes the case of a 69-year-old man with non-small-cell lung cancer who, owing to a mistake, received intravenously 500 mg of vinorelbine. Within 3 days of intoxication, the bone marrow of the patient was damaged with subsequent pancytopenia that did not respond to treatment. On the fifth day after the poisoning, features of intestinal obstruction appeared. The patient died on the sixth day after the drug overdose. The case presented by us constitutes the first description of a fatal iatrogenic poisoning with this drug. Correspondence to Marcin Zawadzki, MD, PhD, Department of Forensic Medicine, Wroclaw Medical University, Mikulicza-Radeckiego 4, PL 50-345 Wroclaw, Poland Tel: +48 717 841 480; fax: +48 717 575 006; e-mail: marcin.zawadzki@umed.wroc.pl Received June 23, 2018 Accepted September 27, 2018 Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2A1udbq

Suppression of TGP on myocardial remodeling by regulating the NF-κB pathway

This study aims to investigate the effects of TGP on myocardial remodeling by regulating the nuclear factor kappa B cells (NF-κB) pathway. SD rats were selected and divided into five groups (n = 8), control, sham-operated, Captopril, low dose TGP and high dose TGP respectively. The pressure-overload method was adopted by abdominal aorta ligation to induce the CHF. Furthermore, collagen fibers detected by picrosirius red staining and expression of NF-kB, TGF-β1 by immunohistochemistry and observed under a polarized microscope and assessed by image-pro plus 6.0. Matrix metalloproteinase's (MMP)-2, -9 mRNA levels by reverse transcription PCR (RT-PCR), the concentration of angiotensin II was determined by radioimmunoassay and ELISA was employed to determine the cytokine IL-1β. It was ...

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OMXs9R

Management Algorithm for Interrupting Mother to Child Transmission of Hepatitis B Virus

In areas where hepatitis B virus (HBV) is endemic, mother to child transmission (MTCT) is the major route of infection of children. Blocking MTCT of HBV would therefore reduce its prevalence. The China Foundation of Hepatitis Prevention and Control organized a team of specialists in infectious diseases, hepatology, immunology, obstetrics, and public health to develop an algorithm for interrupting MTCT of HBV, based on the most recent hepatitis B guidelines and latest evidence. This algorithm comprises 10 steps and has been adopted in clinical practice in China. (Source: Clinical Gastroenterology and Hepatology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2NvUWAl

Assessment of microvascular dysfunction in acute limb ischemia‐reperfusion injury

Journal of Magnetic Resonance Imaging, EarlyView.


from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PoulXr

Minority Residents Experience Burdens Linked to Race/Ethnicity

Residents describe daily barrage of microaggression, bias; being tasked as race/ethnicity ambassadors (Source: The Doctors Lounge - Psychiatry)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2IKn0yW

Suppression of TGP on myocardial remodeling by regulating the NF-κB pathway

This study aims to investigate the effects of TGP on myocardial remodeling by regulating the nuclear factor kappa B cells (NF-κB) pathway. SD rats were selected and divided into five groups (n = 8), control, sham-operated, Captopril, low dose TGP and high dose TGP respectively. The pressure-overload method was adopted by abdominal aorta ligation to induce the CHF. Furthermore, collagen fibers detected by picrosirius red staining and expression of NF-kB, TGF-β1 by immunohistochemistry and observed under a polarized microscope and assessed by image-pro plus 6.0. Matrix metalloproteinase's (MMP)-2, -9 mRNA levels by reverse transcription PCR (RT-PCR), the concentration of angiotensin II was determined by radioimmunoassay and ELISA was employed to determine the cytokine IL-1β. It was ...

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OMXs9R

Management Algorithm for Interrupting Mother to Child Transmission of Hepatitis B Virus

In areas where hepatitis B virus (HBV) is endemic, mother to child transmission (MTCT) is the major route of infection of children. Blocking MTCT of HBV would therefore reduce its prevalence. The China Foundation of Hepatitis Prevention and Control organized a team of specialists in infectious diseases, hepatology, immunology, obstetrics, and public health to develop an algorithm for interrupting MTCT of HBV, based on the most recent hepatitis B guidelines and latest evidence. This algorithm comprises 10 steps and has been adopted in clinical practice in China. (Source: Clinical Gastroenterology and Hepatology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2NvUWAl

People rarely outgrow seafood allergies

(Reuters Health) - A small study of children and adults in Canada suggests that fish and shellfish allergies don't usually resolve over time. (Source: Reuters: Health)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2pMtEME

Assessment of microvascular dysfunction in acute limb ischemia‐reperfusion injury

Journal of Magnetic Resonance Imaging, EarlyView.


from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PoulXr

Minority Residents Experience Burdens Linked to Race/Ethnicity

Residents describe daily barrage of microaggression, bias; being tasked as race/ethnicity ambassadors (Source: The Doctors Lounge - Psychiatry)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2IKn0yW

People rarely outgrow seafood allergies

(Reuters Health) - A small study of children and adults in Canada suggests that fish and shellfish allergies don't usually resolve over time. (Source: Reuters: Health)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2pMtEME

Minority Residents Experience Burdens Linked to Race/Ethnicity

Residents describe daily barrage of microaggression, bias; being tasked as race/ethnicity ambassadors (Source: The Doctors Lounge - Psychiatry)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2IKn0yW

People rarely outgrow seafood allergies

(Reuters Health) - A small study of children and adults in Canada suggests that fish and shellfish allergies don't usually resolve over time. (Source: Reuters: Health)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2pMtEME

Minority Residents Experience Burdens Linked to Race/Ethnicity

Residents describe daily barrage of microaggression, bias; being tasked as race/ethnicity ambassadors (Source: The Doctors Lounge - Psychiatry)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2IKn0yW

Increasing trends of anaphylaxis-related events: an analysis of anaphylaxis using nationwide data in Taiwan, 2001 –2013

ConclusionThe incidence rate of anaphylaxis in Taiwan  has increased at an average rate of 5% annually since 2001, paralleling the rising trends in several Western countries. (Source: World Allergy Organization Journal)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PmupqU

Increased STAT1 Amounts Correlate with the Phospho-STAT1 Level in STAT1 Gain-of-function Defects

(Source: Journal of Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2yd85JI

Contribution of Vaccination to the Reduction of Infectious Mortality in Ukraine in the Second Half of the 20th and Early 21st Century: A Comparative Population Based Study of the Dynamics and Structure of Infectious Mortality and Incidence

Viral Immunology, Ahead of Print. (Source: Viral Immunology)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PpwBOd

Effects of cigarette smoke on immunity, neuroinflammation and multiple sclerosis

Cigarette smoking is the most prominent significant cause of death and morbidity. It is recognised as a risk factor for a number of immune mediated, inflammatory diseases including multiple sclerosis (MS). Here, we review the complex immunological effects of smoking on the immune system, which include enhancement of inflammatory responses with a parallel reduction of some immune defences, resulting in an increased susceptibility to infection and a persistent proinflammatory environment.We discuss the effect of smoking on the susceptibility, clinical course, disability, and mortality in MS, the likely benefits of smoking cessation, and the specific immunological effects of smoking in MS. (Source: Journal of Neuroimmunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2ycHPz5

Fourth Update on the Iranian National Registry of Primary Immunodeficiencies: Integration of Molecular Diagnosis

ConclusionsDuring a 20-year registration of Iranian PID patients, significant changes have been observed by increasing the awareness of the medical community, national PID network establishment, improving therapeutic facilities, and recently by inclusion of the molecular diagnosis. The current collective study of PID phenotypes and genotypes provides a major source for ethnic surveillance, newborn screening, and genetic consultation for prenatal and preimplantation genetic diagnosis. (Source: Journal of Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PuVmZC

Flow mediated vasodilation assay indicates no endothelial dysfunction in hereditary angioedema patients with C1-inhibitor deficiency

Hereditary angioedema with C1 inhibitor deficiency (C1-INH-HAE) is a rare, potentially life-threatening disorder characterized by recurrent edematous attacks. The edema formation is the consequence of interaction of bradykinin and various vasoactive peptides with endothelium. Besides these agents, danazol, a modified testosterone derivative used in these patients to prevent edematous attacks, can also affect the function of the endothelium, since it shifts the blood lipid profile to a pro-atherogenic phenotype. (Source: Annals of Allergy, Asthma and Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PoXnX5

Neutropenia as a sign of immunodeficiency

(Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2yccNHr

Upregulated P-Rex1 exacerbates human airway smooth muscle hyperplasia in asthma

P-Rex1, a Rac-selective activator is aberrantly upregulated in airway smooth muscle of subjects with asthma compared to non-asthmatics, and augments cell proliferation, thus contributing to airway smooth muscle hyperplasia and remodeling in severe asthma. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2ycHNqX

Intestinal dysbiosis in Inflammatory Bowel Disease associated with primary immunodeficiency.

The gut microbiota plays a key role in host physiology and is an actor in inflammatory bowel disease pathogenesis. Patients with primary immunodeficiency causing intestinal inflammation have disease-specific dysbiosis. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Pqfps2

Maintained thymic output of conventional and regulatory T cells during human pregnancy

In contrast to the rodent-based conception, the output of CD4+ T-cells is preserved, and for Treg cells even increased, during human pregnancy. This indicates a central thymic role in tolerance needed for a successful pregnancy. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2ybEMXP

Hsa-mir-144-3p is increased in umbilical cord serum of infants developing atopic dermatitis

Elevated hsa-miR-144-3p levels in umbilical cord serum may lower the threshold for allergen-induced skin inflammation. This gives insight in to possible mechanisms promoting early life atopic dermatitis and highlights the importance of skin barrier protection. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PmmUA9

Real life treatment of Cholinergic Urticaria with Omalizumab

Retrospective analysis of omalizumab treatment in 16 cholinergic urticaria (CholU) patients revealed effectiveness in two third of the patients, especially in female patients. Most non-responders to standard-dosed omalizumab benefited from updosing. Non-responders raise the question of different pathomechanisms in these patients. (Source: Journal of Allergy and Clinical Immunology)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2yaFLHE

CSF3R/CD114 mediates infection-dependent transition to severe asthma

We show that CSF3 expression in bronchial biopsies correlates with neutrophilic inflammation and Muc5AC in poorly controlled asthma and in vivo, CSF3R signalling governs excessive infection-dependent neutrophilic inflammation and mucus dependent airways hyper-reactivity in mice. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Ppe6JT

A Personal Perspective on Mentoring

(Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2ybofDa

Increased STAT1 Amounts Correlate with the Phospho-STAT1 Level in STAT1 Gain-of-function Defects

(Source: Journal of Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2yd85JI

Contribution of Vaccination to the Reduction of Infectious Mortality in Ukraine in the Second Half of the 20th and Early 21st Century: A Comparative Population Based Study of the Dynamics and Structure of Infectious Mortality and Incidence

Viral Immunology, Ahead of Print. (Source: Viral Immunology)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PpwBOd

Effects of cigarette smoke on immunity, neuroinflammation and multiple sclerosis

Cigarette smoking is the most prominent significant cause of death and morbidity. It is recognised as a risk factor for a number of immune mediated, inflammatory diseases including multiple sclerosis (MS). Here, we review the complex immunological effects of smoking on the immune system, which include enhancement of inflammatory responses with a parallel reduction of some immune defences, resulting in an increased susceptibility to infection and a persistent proinflammatory environment.We discuss the effect of smoking on the susceptibility, clinical course, disability, and mortality in MS, the likely benefits of smoking cessation, and the specific immunological effects of smoking in MS. (Source: Journal of Neuroimmunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2ycHPz5

Fourth Update on the Iranian National Registry of Primary Immunodeficiencies: Integration of Molecular Diagnosis

ConclusionsDuring a 20-year registration of Iranian PID patients, significant changes have been observed by increasing the awareness of the medical community, national PID network establishment, improving therapeutic facilities, and recently by inclusion of the molecular diagnosis. The current collective study of PID phenotypes and genotypes provides a major source for ethnic surveillance, newborn screening, and genetic consultation for prenatal and preimplantation genetic diagnosis. (Source: Journal of Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PuVmZC

From the Pages of AllergyWatch

John J. Oppenheimer, MD, Assistant Editor (Source: Annals of Allergy, Asthma and Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2ydIIr2

Flow mediated vasodilation assay indicates no endothelial dysfunction in hereditary angioedema patients with C1-inhibitor deficiency

Hereditary angioedema with C1 inhibitor deficiency (C1-INH-HAE) is a rare, potentially life-threatening disorder characterized by recurrent edematous attacks. The edema formation is the consequence of interaction of bradykinin and various vasoactive peptides with endothelium. Besides these agents, danazol, a modified testosterone derivative used in these patients to prevent edematous attacks, can also affect the function of the endothelium, since it shifts the blood lipid profile to a pro-atherogenic phenotype. (Source: Annals of Allergy, Asthma and Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PoXnX5

Neutropenia as a sign of immunodeficiency

(Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2yccNHr

EROS mutations: decreased NADPH oxidase function and chronic granulomatous disease

We demonstrate for the first time that EROS (CYBC1/C17ORF62) regulates abundance of the gp91phox-p22phox heterodimer of the phagocyte NADPH oxidase in human cells and that EROS mutations are a novel cause of chronic granulomatous disease. (Source: Journal of Allergy and Clinical Immunology)

MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PmukDC

Upregulated P-Rex1 exacerbates human airway smooth muscle hyperplasia in asthma

P-Rex1, a Rac-selective activator is aberrantly upregulated in airway smooth muscle of subjects with asthma compared to non-asthmatics, and augments cell proliferation, thus contributing to airway smooth muscle hyperplasia and remodeling in severe asthma. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2ycHNqX

Intestinal dysbiosis in Inflammatory Bowel Disease associated with primary immunodeficiency.

The gut microbiota plays a key role in host physiology and is an actor in inflammatory bowel disease pathogenesis. Patients with primary immunodeficiency causing intestinal inflammation have disease-specific dysbiosis. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Pqfps2

Maintained thymic output of conventional and regulatory T cells during human pregnancy

In contrast to the rodent-based conception, the output of CD4+ T-cells is preserved, and for Treg cells even increased, during human pregnancy. This indicates a central thymic role in tolerance needed for a successful pregnancy. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2ybEMXP

Hsa-mir-144-3p is increased in umbilical cord serum of infants developing atopic dermatitis

Elevated hsa-miR-144-3p levels in umbilical cord serum may lower the threshold for allergen-induced skin inflammation. This gives insight in to possible mechanisms promoting early life atopic dermatitis and highlights the importance of skin barrier protection. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PmmUA9

Real life treatment of Cholinergic Urticaria with Omalizumab

Retrospective analysis of omalizumab treatment in 16 cholinergic urticaria (CholU) patients revealed effectiveness in two third of the patients, especially in female patients. Most non-responders to standard-dosed omalizumab benefited from updosing. Non-responders raise the question of different pathomechanisms in these patients. (Source: Journal of Allergy and Clinical Immunology)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2yaFLHE

CSF3R/CD114 mediates infection-dependent transition to severe asthma

We show that CSF3 expression in bronchial biopsies correlates with neutrophilic inflammation and Muc5AC in poorly controlled asthma and in vivo, CSF3R signalling governs excessive infection-dependent neutrophilic inflammation and mucus dependent airways hyper-reactivity in mice. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Ppe6JT

A Personal Perspective on Mentoring

(Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2ybofDa

4 Reasons to Use Curriculum-Based Intervention

Not using curriculum-based intervention?  You may be working too hard. As a young speech-language pathologist, I was confronted with a large and staggeringly diverse caseload. It nearly brought an immediate end to my early career. I worked across two campuses with 65 Spanish-speaking students and conducted evaluations on another five campuses. Nearly half of my students were 3-year-olds in a half-day program, and many of them had multiple disabilities. I wasn't alone. Educators in my district also taught students from a range of cultural and linguistic backgrounds. Working with students from diverse backgrounds poses some of the greatest benefits and the biggest challenges. On one hand, we're exposed to unique and interesting cultures and can make massive positive change in their educ...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2NyJpAf

4 Reasons to Use Curriculum-Based Intervention

Not using curriculum-based intervention?  You may be working too hard. As a young speech-language pathologist, I was confronted with a large and staggeringly diverse caseload. It nearly brought an immediate end to my early career. I worked across two campuses with 65 Spanish-speaking students and conducted evaluations on another five campuses. Nearly half of my students were 3-year-olds in a half-day program, and many of them had multiple disabilities. I wasn't alone. Educators in my district also taught students from a range of cultural and linguistic backgrounds. Working with students from diverse backgrounds poses some of the greatest benefits and the biggest challenges. On one hand, we're exposed to unique and interesting cultures and can make massive positive change in their educ...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2NyJpAf

Anaesthesia care team improves outcomes in surgical patients compared with solo anaesthesiologist: An observational study

BACKGROUND In anaesthesiology, little attention has been drawn to the role of anaesthesia nurses as support personnel on quality of care. OBJECTIVES To compare the impact of anaesthesia by an anaesthesiologist alone (solo anaesthesiologist) or in combination with an anaesthesia nurse (anaesthesia care team) on 30-day postoperative mortality and hospital length of stay. RESULTS Anaesthesia was performed by solo anaesthesiologists in 2832 patients and by an anaesthesia care team in 2842 patients. The two groups were comparable in respect of sex and duration of anaesthesia but differed notably for age, American Society of Anesthesiologists' physical status score and type of surgery. Propensity score matching was performed by logistic regression to adjust for baseline differences between the two groups and 2095 pairs of perfectly matched patients were formed. The latter evidenced a significantly lower 30-day mortality rate for the anaesthesia care team compared with solo anaesthesiologists (0.76 vs. 1.56%, P = 0.0014). Length of hospital stay was also significantly reduced when an anaesthesia nurse was present (4.9 ± 10.1 vs. 5.6 ± 11.5 days, P = 0.0011). CONCLUSION Anaesthesia given by the combination of an anaesthesiologist and an anaesthesia nurse is associated with decreased 30-day postoperative mortality and shorter length of stay when compared with a solo anaesthesiologist. Even if without any demonstration of causality, this emphasises the benefits of the anaesthesia care team model. TRIAL REGISTRATION CCB 325201730849. Correspondence to Patrice Forget, Anaesthesiology and Perioperative Medicine, Vrije Universiteit Brussel (VUB), Universitair Ziekenhuis Brussel (UZ Brussel), Laarbeeklaan 101, 1090 Brussels, Belgium Tel: +32 24773058; e-mail: forgetpatrice@yahoo.fr Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website (https://ift.tt/2ylyqmW). © 2018 European Society of Anaesthesiology

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2RyFFlk

4 Reasons to Use Curriculum-Based Intervention

Not using curriculum-based intervention?  You may be working too hard. As a young speech-language pathologist, I was confronted with a large and staggeringly diverse caseload. It nearly brought an immediate end to my early career. I worked across two campuses with 65 Spanish-speaking students and conducted evaluations on another five campuses. Nearly half of my students were 3-year-olds in a half-day program, and many of them had multiple disabilities. I wasn't alone. Educators in my district also taught students from a range of cultural and linguistic backgrounds. Working with students from diverse backgrounds poses some of the greatest benefits and the biggest challenges. On one hand, we're exposed to unique and interesting cultures and can make massive positive change in their educ...

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2NyJpAf

Anaesthesia care team improves outcomes in surgical patients compared with solo anaesthesiologist: An observational study

BACKGROUND In anaesthesiology, little attention has been drawn to the role of anaesthesia nurses as support personnel on quality of care. OBJECTIVES To compare the impact of anaesthesia by an anaesthesiologist alone (solo anaesthesiologist) or in combination with an anaesthesia nurse (anaesthesia care team) on 30-day postoperative mortality and hospital length of stay. RESULTS Anaesthesia was performed by solo anaesthesiologists in 2832 patients and by an anaesthesia care team in 2842 patients. The two groups were comparable in respect of sex and duration of anaesthesia but differed notably for age, American Society of Anesthesiologists' physical status score and type of surgery. Propensity score matching was performed by logistic regression to adjust for baseline differences between the two groups and 2095 pairs of perfectly matched patients were formed. The latter evidenced a significantly lower 30-day mortality rate for the anaesthesia care team compared with solo anaesthesiologists (0.76 vs. 1.56%, P = 0.0014). Length of hospital stay was also significantly reduced when an anaesthesia nurse was present (4.9 ± 10.1 vs. 5.6 ± 11.5 days, P = 0.0011). CONCLUSION Anaesthesia given by the combination of an anaesthesiologist and an anaesthesia nurse is associated with decreased 30-day postoperative mortality and shorter length of stay when compared with a solo anaesthesiologist. Even if without any demonstration of causality, this emphasises the benefits of the anaesthesia care team model. TRIAL REGISTRATION CCB 325201730849. Correspondence to Patrice Forget, Anaesthesiology and Perioperative Medicine, Vrije Universiteit Brussel (VUB), Universitair Ziekenhuis Brussel (UZ Brussel), Laarbeeklaan 101, 1090 Brussels, Belgium Tel: +32 24773058; e-mail: forgetpatrice@yahoo.fr Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Website (https://ift.tt/2ylyqmW). © 2018 European Society of Anaesthesiology

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2RyFFlk

4 Reasons to Use Curriculum-Based Intervention

Not using curriculum-based intervention?  You may be working too hard. As a young speech-language pathologist, I was confronted with a large and staggeringly diverse caseload. It nearly brought an immediate end to my early career. I worked across two campuses with 65 Spanish-speaking students and conducted evaluations on another five campuses. Nearly half of my students were 3-year-olds in a half-day program, and many of them had multiple disabilities. I wasn't alone. Educators in my district also taught students from a range of cultural and linguistic backgrounds. Working with students from diverse backgrounds poses some of the greatest benefits and the biggest challenges. On one hand, we're exposed to unique and interesting cultures and can make massive positive change in their educ...

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2NyJpAf

Bone repair in craniofacial defects treated with different doses of alendronate: a histological, histomorphometric, and immunohistochemical study

Abstract

Objective

The objective of the study is to evaluate bone repair in rats treated with different alendronate doses.

Matherials and methods

Sixty female rats ovariectomized were randomly divided in three groups: group C (control group), group A1 (ALN/1 mg/kg), and A2 (ALN/ 3 mg/kg). Each animal received subcutaneous applications of sodium alendronate at a dose correspondent to group A1 or A2 three times a week, while the control group received 0.9% saline solution. After 4 weeks of application, a critical defect was created in the calvaria of animals of all groups. The defect was filled by particulate autogenous bone. The applications were maintained until euthanasia, which occurred 15 and 60 days after the surgical procedure. The pieces were sent for histological, histomorphometric and immunohistochemical analysis. The data were submitted to statistical analysis with significance level of 0.05.

Results

The descriptive histological analysis demonstrated an increase in bone neoformation in both groups treated with alendronate when compared to the control group. The histomorphometric analysis showed an increase in the amount of neoformed bone in A1 and A2 groups when compared to group C, both at 15 days (p = 0.0002) and at 60 days (p = 0.001). In the immunohistochemical analysis, it was possible to observe a difference in immunolabeling just for Mmp2 at the time of 60 days in A1 (p = 0.001) and A2 (p = 0.023) when compared to the control group.

Conclusion

Systemic delivery of alendronate, regardless of the dose, increased the amount of bone neoformation.

Clinical relevance

Prescription of sodium alendronate at 1 mg/kg for improvement of bone neoformation in bone graft procedures.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2ycPPjE

Effect of sucralfate against hydrochloric acid-induced dental erosion

Abstract

Objective

Devising effective measures for the prevention of hydrochloric acid (HCl)-induced erosion is of great significance. This is even more important in dentine, in which products have limited diffusion. Therefore, agents that can bind to proteins forming an acid-resistant gel-like coat, such as sucralfate, may stand out as a promising alternative. This study investigated the protective effect of sucralfate suspensions against HCl-induced dental erosion.

Materials and methods

In the first experiment, hydroxyapatite (HAp) crystals were pre-treated with a commercial sucralfate suspension (CoSS, pH 5.9), a stannous-containing sodium fluoride solution (NaF/SnCl₂ pH 4.5), two prepared sucralfate suspensions (PrSS, pH 5.9 and 4.5), or deionized water (DI, control). HAp dissolution was measured using a pH-stat system. In a subsequent experiment, embedded/polished enamel and root dentine slabs were allocated into five groups to be treated with one of the tested substances prior to and during erosion-remineralization cycles (HCl-2 min + artificial saliva 60 min, two times per day, 5 days). Surface loss was assessed profilometrically. Data were analyzed by ANOVA and Tukey's tests.

Results

HAp dissolution was as follows: NaF/SnCl₂ < CoSS < PrSS/pH 4.5, while PrSS/pH 5.9 = DI and both did not differ from CoSS and PrSS/pH 4.5. In enamel, surface loss did not differ between CoSS and PrSS/pH 4.5, with both having lower surface loss than PrSS/pH 5.9 and DI and NaF/SnCl₂ differing only from DI. In root dentine, surface loss was as follows: CoSS < PrSS/pH 5.9 < (NaF/SnCl₂ = DI), while PrSS/pH 4.5 = CoSS = PrSS/pH 5.9.

Conclusion

Sucralfate suspension provided anti-erosive protection to HCl-induced erosion.

Clinical relevance

Sucralfate may protect teeth against erosion caused by gastric acid.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2ONX5vM

Increasing trends of anaphylaxis-related events: an analysis of anaphylaxis using nationwide data in Taiwan, 2001–2013

Abstract

Background

Anaphylaxis is a severe, potentially fatal, and systemic allergic reaction. Previous studies document increasing trends in incidence rates of anaphylaxis-related events in Western countries, yet little is known about the incidence and trend of anaphylaxis in Asia. In this study, we aimed to determine time trends in incidence rates of anaphylaxis-related events in Taiwan from 2001 through 2013.

Methods

We utilized medical claims data from the National Health Insurance Research Databases in Taiwan. We identified anaphylaxis-related events (ICD-9-CM-codes: 995.0, 995.60–995.69, 999.41–999.42, and 999.49) and calculated incidence rates. Poisson regression models were applied to examine trends and incidence rates.

Results

A total of 2496 patients (mean age, 45.11 years; 56% male) with first-time anaphylaxis were identified during 34,430,000 person-years of observation time. The overall incidence of anaphylaxis was 7.25 (95% confidence interval (CI) = 6.97–7.53) per 100,000 person-years, increasing from 4.79 in 2001 to 8.20 in 2013, with an incidence rate ratio (IRR) of 1.05 (95%CI = 1.04–1.06). Over the 13-year period, the increasing trends were found in incident diagnosis of anaphylaxis-related outpatient or emergency department visits (IRR = 1.06, 95%CI = 1.05–1.08) and admissions to intensive care units (IRR = 1.06, 95%CI = 1.03–1.10), whereas the trends in incidence of anaphylaxis-related hospitalizations remained steady. The proportion of patients requiring hospitalizations among all patients with anaphylaxis (p_{_trend} = 0.01), as well as the proportion requiring intensive care treatment among patients who were hospitalized (p_{_trend} = 0.01), both increased with age.

Conclusion

The incidence rate of anaphylaxis in Taiwan has increased at an average rate of 5% annually since 2001, paralleling the rising trends in several Western countries.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OItOCT

Bone repair in craniofacial defects treated with different doses of alendronate: a histological, histomorphometric, and immunohistochemical study

Abstract

Objective

The objective of the study is to evaluate bone repair in rats treated with different alendronate doses.

Matherials and methods

Sixty female rats ovariectomized were randomly divided in three groups: group C (control group), group A1 (ALN/1 mg/kg), and A2 (ALN/ 3 mg/kg). Each animal received subcutaneous applications of sodium alendronate at a dose correspondent to group A1 or A2 three times a week, while the control group received 0.9% saline solution. After 4 weeks of application, a critical defect was created in the calvaria of animals of all groups. The defect was filled by particulate autogenous bone. The applications were maintained until euthanasia, which occurred 15 and 60 days after the surgical procedure. The pieces were sent for histological, histomorphometric and immunohistochemical analysis. The data were submitted to statistical analysis with significance level of 0.05.

Results

The descriptive histological analysis demonstrated an increase in bone neoformation in both groups treated with alendronate when compared to the control group. The histomorphometric analysis showed an increase in the amount of neoformed bone in A1 and A2 groups when compared to group C, both at 15 days (p = 0.0002) and at 60 days (p = 0.001). In the immunohistochemical analysis, it was possible to observe a difference in immunolabeling just for Mmp2 at the time of 60 days in A1 (p = 0.001) and A2 (p = 0.023) when compared to the control group.

Conclusion

Systemic delivery of alendronate, regardless of the dose, increased the amount of bone neoformation.

Clinical relevance

Prescription of sodium alendronate at 1 mg/kg for improvement of bone neoformation in bone graft procedures.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2ycPPjE

Effect of sucralfate against hydrochloric acid-induced dental erosion

Abstract

Objective

Devising effective measures for the prevention of hydrochloric acid (HCl)-induced erosion is of great significance. This is even more important in dentine, in which products have limited diffusion. Therefore, agents that can bind to proteins forming an acid-resistant gel-like coat, such as sucralfate, may stand out as a promising alternative. This study investigated the protective effect of sucralfate suspensions against HCl-induced dental erosion.

Materials and methods

In the first experiment, hydroxyapatite (HAp) crystals were pre-treated with a commercial sucralfate suspension (CoSS, pH 5.9), a stannous-containing sodium fluoride solution (NaF/SnCl₂ pH 4.5), two prepared sucralfate suspensions (PrSS, pH 5.9 and 4.5), or deionized water (DI, control). HAp dissolution was measured using a pH-stat system. In a subsequent experiment, embedded/polished enamel and root dentine slabs were allocated into five groups to be treated with one of the tested substances prior to and during erosion-remineralization cycles (HCl-2 min + artificial saliva 60 min, two times per day, 5 days). Surface loss was assessed profilometrically. Data were analyzed by ANOVA and Tukey's tests.

Results

HAp dissolution was as follows: NaF/SnCl₂ < CoSS < PrSS/pH 4.5, while PrSS/pH 5.9 = DI and both did not differ from CoSS and PrSS/pH 4.5. In enamel, surface loss did not differ between CoSS and PrSS/pH 4.5, with both having lower surface loss than PrSS/pH 5.9 and DI and NaF/SnCl₂ differing only from DI. In root dentine, surface loss was as follows: CoSS < PrSS/pH 5.9 < (NaF/SnCl₂ = DI), while PrSS/pH 4.5 = CoSS = PrSS/pH 5.9.

Conclusion

Sucralfate suspension provided anti-erosive protection to HCl-induced erosion.

Clinical relevance

Sucralfate may protect teeth against erosion caused by gastric acid.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2ONX5vM

Increasing trends of anaphylaxis-related events: an analysis of anaphylaxis using nationwide data in Taiwan, 2001–2013

Abstract

Background

Anaphylaxis is a severe, potentially fatal, and systemic allergic reaction. Previous studies document increasing trends in incidence rates of anaphylaxis-related events in Western countries, yet little is known about the incidence and trend of anaphylaxis in Asia. In this study, we aimed to determine time trends in incidence rates of anaphylaxis-related events in Taiwan from 2001 through 2013.

Methods

We utilized medical claims data from the National Health Insurance Research Databases in Taiwan. We identified anaphylaxis-related events (ICD-9-CM-codes: 995.0, 995.60–995.69, 999.41–999.42, and 999.49) and calculated incidence rates. Poisson regression models were applied to examine trends and incidence rates.

Results

A total of 2496 patients (mean age, 45.11 years; 56% male) with first-time anaphylaxis were identified during 34,430,000 person-years of observation time. The overall incidence of anaphylaxis was 7.25 (95% confidence interval (CI) = 6.97–7.53) per 100,000 person-years, increasing from 4.79 in 2001 to 8.20 in 2013, with an incidence rate ratio (IRR) of 1.05 (95%CI = 1.04–1.06). Over the 13-year period, the increasing trends were found in incident diagnosis of anaphylaxis-related outpatient or emergency department visits (IRR = 1.06, 95%CI = 1.05–1.08) and admissions to intensive care units (IRR = 1.06, 95%CI = 1.03–1.10), whereas the trends in incidence of anaphylaxis-related hospitalizations remained steady. The proportion of patients requiring hospitalizations among all patients with anaphylaxis (p_{_trend} = 0.01), as well as the proportion requiring intensive care treatment among patients who were hospitalized (p_{_trend} = 0.01), both increased with age.

Conclusion

The incidence rate of anaphylaxis in Taiwan has increased at an average rate of 5% annually since 2001, paralleling the rising trends in several Western countries.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OItOCT

Siglec-7 engagement by GBS {beta}-protein suppresses pyroptotic cell death of natural killer cells [Immunology and Inflammation]

Natural killer (NK) cells are innate immune lymphocytes that recognize and destroy abnormal host cells, such as tumor cells or those infected by viral pathogens. To safely accomplish these functions, NK cells display activating receptors that detect stress molecules or viral ligands displayed at the cell surface, balanced by inhibitory... (Source: Proceedings of the National Academy of Sciences)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2pKBExr

MAVS deficiency induces gut dysbiotic microbiota conferring a proallergic phenotype [Immunology and Inflammation]

Prominent changes in the gut microbiota (referred to as "dysbiosis") play a key role in the development of allergic disorders, but the underlying mechanisms remain unknown. Study of the delayed-type hypersensitivity (DTH) response in mice contributed to our knowledge of the pathophysiology of human allergic contact dermatitis. Here we report... (Source: Proceedings of the National Academy of Sciences)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2IKBEGo

Cochaperone Mzb1 is a key effector of Blimp1 in plasma cell differentiation and {beta}1-integrin function [Immunology and Inflammation]

Plasma cell differentiation involves coordinated changes in gene expression and functional properties of B cells. Here, we study the role of Mzb1, a Grp94 cochaperone that is expressed in marginal zone (MZ) B cells and during the terminal differentiation of B cells to antibody-secreting cells. By analyzing Mzb1−/−Prdm1+/gfp mice, we... (Source: Proceedings of the National Academy of Sciences)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2pLXOj8

Optimal protection against Salmonella infection requires noncirculating memory [Immunology and Inflammation]

While CD4 Th1 cells are required for resistance to intramacrophage infections, adoptive transfer of Th1 cells is insufficient to protect against Salmonella infection. Using an epitope-tagged vaccine strain of Salmonella, we found that effective protection correlated with expanded Salmonella-specific memory CD4 T cells in circulation and nonlymphoid tissues. However, naive... (Source: Proceedings of the National Academy of Sciences)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2IL3IJL

Innate lymphoid cells, mediators of tissue homeostasis, adaptation and disease tolerance

Immunological Reviews,Volume 286, Issue 1, Page 86-101, November 2018. (Source: Immunological Reviews)

MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2pLjjR9

Siglec-7 engagement by GBS {beta}-protein suppresses pyroptotic cell death of natural killer cells [Immunology and Inflammation]

Natural killer (NK) cells are innate immune lymphocytes that recognize and destroy abnormal host cells, such as tumor cells or those infected by viral pathogens. To safely accomplish these functions, NK cells display activating receptors that detect stress molecules or viral ligands displayed at the cell surface, balanced by inhibitory... (Source: Proceedings of the National Academy of Sciences)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2pKBExr

MAVS deficiency induces gut dysbiotic microbiota conferring a proallergic phenotype [Immunology and Inflammation]

Prominent changes in the gut microbiota (referred to as "dysbiosis") play a key role in the development of allergic disorders, but the underlying mechanisms remain unknown. Study of the delayed-type hypersensitivity (DTH) response in mice contributed to our knowledge of the pathophysiology of human allergic contact dermatitis. Here we report... (Source: Proceedings of the National Academy of Sciences)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2IKBEGo

Cochaperone Mzb1 is a key effector of Blimp1 in plasma cell differentiation and {beta}1-integrin function [Immunology and Inflammation]

Plasma cell differentiation involves coordinated changes in gene expression and functional properties of B cells. Here, we study the role of Mzb1, a Grp94 cochaperone that is expressed in marginal zone (MZ) B cells and during the terminal differentiation of B cells to antibody-secreting cells. By analyzing Mzb1−/−Prdm1+/gfp mice, we... (Source: Proceedings of the National Academy of Sciences)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2pLXOj8

Optimal protection against Salmonella infection requires noncirculating memory [Immunology and Inflammation]

While CD4 Th1 cells are required for resistance to intramacrophage infections, adoptive transfer of Th1 cells is insufficient to protect against Salmonella infection. Using an epitope-tagged vaccine strain of Salmonella, we found that effective protection correlated with expanded Salmonella-specific memory CD4 T cells in circulation and nonlymphoid tissues. However, naive... (Source: Proceedings of the National Academy of Sciences)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2IL3IJL

Innate lymphoid cells, mediators of tissue homeostasis, adaptation and disease tolerance

Immunological Reviews,Volume 286, Issue 1, Page 86-101, November 2018. (Source: Immunological Reviews)

MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2pLjjR9

FDA Approves Marketing of First User-Fitted Hearing Aid

TUESDAY, Oct. 9, 2018 -- The first hearing aid that does not require the assistance of an audiologist or other health care provider has been approved by the U.S. Food and Drug Administration. The Bose Hearing Aid is a user-fitted device for people... (Source: Drugs.com - Pharma News)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Nx2Pp1

Effects of social defeat stress on dopamine D2 receptor isoforms and proteins involved in intracellular trafficking

Chronic social defeat stress induces depression and anxiety-like behaviors in rodents and also responsible for differentiating defeated animals into stress susceptible and resilient groups. The present study i...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2NxLFaE

FDA Approves Marketing of First User-Fitted Hearing Aid

TUESDAY, Oct. 9, 2018 -- The first hearing aid that does not require the assistance of an audiologist or other health care provider has been approved by the U.S. Food and Drug Administration. The Bose Hearing Aid is a user-fitted device for people... (Source: Drugs.com - Pharma News)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Nx2Pp1

Effects of social defeat stress on dopamine D2 receptor isoforms and proteins involved in intracellular trafficking

Chronic social defeat stress induces depression and anxiety-like behaviors in rodents and also responsible for differentiating defeated animals into stress susceptible and resilient groups. The present study i...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2NxLFaE

Standing on the shoulders of mice: adventures in human immunology

NIH Director's Wednesday Afternoon Lecture Series While inbred mice have been a very powerful model for analyzing the immune system, recent advances, both technological and conceptual, have begun to make direct studies of the human immune system possible. This is vitally important from a translational perspective, as mouse models of disease have not been as productive as hoped for in producing " actionable intelligence " with which to diagnose and treat patients. Another benefit is that human work is almost unexplored territory for immunologists in our present time, where asking basic questions often results in unexpected answers, as the compromises that were necessary to make in laboratory mice-virtually eliminating genetic and environmental heterogeneity-are unavoidable in human bein...

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2QGzSZX

Standing on the shoulders of mice: adventures in human immunology

NIH Director's Wednesday Afternoon Lecture Series While inbred mice have been a very powerful model for analyzing the immune system, recent advances, both technological and conceptual, have begun to make direct studies of the human immune system possible. This is vitally important from a translational perspective, as mouse models of disease have not been as productive as hoped for in producing " actionable intelligence " with which to diagnose and treat patients. Another benefit is that human work is almost unexplored territory for immunologists in our present time, where asking basic questions often results in unexpected answers, as the compromises that were necessary to make in laboratory mice-virtually eliminating genetic and environmental heterogeneity-are unavoidable in human bein...

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2QGzSZX

CCR Eminent Lecture: The Multifaceted Function of the PD-1 Pathway

NCI Center for Cancer Research Eminent Lecture Arlene Sharpe is the George Fabyan Professor of Comparative Pathology, Head of the Division of Immunology and Interim Co-Chair of the Department of Microbiology and Immunobiology at Harvard Medical School. She is a member of the Department of Pathology at Brigham and Women ' s Hospital, an Associate Member at the Broad Institute of MIT and Harvard, Leader of the Cancer Immunology Program at the Dana-Farber/Harvard Cancer Center and Co-Director of the Evergrande Center for Immunologic Diseases at Harvard Medical School and Brigham and Women ' s Hospital. Dr. Sharpe earned her A.B. from Harvard University and her M.D. and Ph.D. degrees from Harvard Medical School. She completed residency training in Pathology at Brigham and Women ' s Hospi...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2A1A1RT

A Personal Perspective on Mentoring

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2QD1cIk

Maintained thymic output of conventional and regulatory T cells during human pregnancy

In contrast to the rodent-based conception, the output of CD4+ T-cells is preserved, and for Treg cells even increased, during human pregnancy. This indicates a central thymic role in tolerance needed for a successful pregnancy.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2A1d2GO

CSF3R/CD114 mediates infection-dependent transition to severe asthma

We show that CSF3 expression in bronchial biopsies correlates with neutrophilic inflammation and Muc5AC in poorly controlled asthma and in vivo, CSF3R signalling governs excessive infection-dependent neutrophilic inflammation and mucus dependent airways hyper-reactivity in mice.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2QGyQgt

Neutropenia as a sign of immunodeficiency

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2A0rSx5

Real life treatment of Cholinergic Urticaria with Omalizumab

Retrospective analysis of omalizumab treatment in 16 cholinergic urticaria (CholU) patients revealed effectiveness in two third of the patients, especially in female patients. Most non-responders to standard-dosed omalizumab benefited from updosing. Non-responders raise the question of different pathomechanisms in these patients.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2QGyKW9

Intestinal dysbiosis in Inflammatory Bowel Disease associated with primary immunodeficiency.

The gut microbiota plays a key role in host physiology and is an actor in inflammatory bowel disease pathogenesis. Patients with primary immunodeficiency causing intestinal inflammation have disease-specific dysbiosis.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2A15K60

EROS mutations: decreased NADPH oxidase function and chronic granulomatous disease

We demonstrate for the first time that EROS (CYBC1/C17ORF62) regulates abundance of the gp91phox-p22phox heterodimer of the phagocyte NADPH oxidase in human cells and that EROS mutations are a novel cause of chronic granulomatous disease.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2A2SfCG

Upregulated P-Rex1 exacerbates human airway smooth muscle hyperplasia in asthma

P-Rex1, a Rac-selective activator is aberrantly upregulated in airway smooth muscle of subjects with asthma compared to non-asthmatics, and augments cell proliferation, thus contributing to airway smooth muscle hyperplasia and remodeling in severe asthma.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2QGhaS8

A Personal Perspective on Mentoring

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2QD1cIk

Maintained thymic output of conventional and regulatory T cells during human pregnancy

In contrast to the rodent-based conception, the output of CD4+ T-cells is preserved, and for Treg cells even increased, during human pregnancy. This indicates a central thymic role in tolerance needed for a successful pregnancy.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2A1d2GO

CSF3R/CD114 mediates infection-dependent transition to severe asthma

We show that CSF3 expression in bronchial biopsies correlates with neutrophilic inflammation and Muc5AC in poorly controlled asthma and in vivo, CSF3R signalling governs excessive infection-dependent neutrophilic inflammation and mucus dependent airways hyper-reactivity in mice.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2QGyQgt

Real life treatment of Cholinergic Urticaria with Omalizumab

Retrospective analysis of omalizumab treatment in 16 cholinergic urticaria (CholU) patients revealed effectiveness in two third of the patients, especially in female patients. Most non-responders to standard-dosed omalizumab benefited from updosing. Non-responders raise the question of different pathomechanisms in these patients.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2QGyKW9

Intestinal dysbiosis in Inflammatory Bowel Disease associated with primary immunodeficiency.

The gut microbiota plays a key role in host physiology and is an actor in inflammatory bowel disease pathogenesis. Patients with primary immunodeficiency causing intestinal inflammation have disease-specific dysbiosis.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2A15K60

Hsa-mir-144-3p is increased in umbilical cord serum of infants developing atopic dermatitis

Elevated hsa-miR-144-3p levels in umbilical cord serum may lower the threshold for allergen-induced skin inflammation. This gives insight in to possible mechanisms promoting early life atopic dermatitis and highlights the importance of skin barrier protection.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2QBy8kz

EROS mutations: decreased NADPH oxidase function and chronic granulomatous disease

We demonstrate for the first time that EROS (CYBC1/C17ORF62) regulates abundance of the gp91phox-p22phox heterodimer of the phagocyte NADPH oxidase in human cells and that EROS mutations are a novel cause of chronic granulomatous disease.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2A2SfCG

Upregulated P-Rex1 exacerbates human airway smooth muscle hyperplasia in asthma

P-Rex1, a Rac-selective activator is aberrantly upregulated in airway smooth muscle of subjects with asthma compared to non-asthmatics, and augments cell proliferation, thus contributing to airway smooth muscle hyperplasia and remodeling in severe asthma.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2QGhaS8

FDA Approves Marketing of First User-Fitted Hearing Aid

TUESDAY, Oct. 9, 2018 -- The first hearing aid that does not require the assistance of an audiologist or other health care provider has been approved by the U.S. Food and Drug Administration. The Bose Hearing Aid is a user-fitted device for people... (Source: Drugs.com - Pharma News)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Nx2Pp1

Comparison of Erich arch bar versus embrasure wires for intraoperative intermaxillary fixation in mandibular fractures

ConclusionEmbrasure wire technique is a quick, easy, and reliable technique for minimally or moderately displaced fractured mandible and had better clinical outcomes than did patients that underwent the Erich arch bar technique. (Source: Oral and Maxillofacial Surgery)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OMP0HS

FDA Approves Marketing of First User-Fitted Hearing Aid

TUESDAY, Oct. 9, 2018 -- The first hearing aid that does not require the assistance of an audiologist or other health care provider has been approved by the U.S. Food and Drug Administration. The Bose Hearing Aid is a user-fitted device for people... (Source: Drugs.com - Pharma News)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Nx2Pp1

Comparison of Erich arch bar versus embrasure wires for intraoperative intermaxillary fixation in mandibular fractures

ConclusionEmbrasure wire technique is a quick, easy, and reliable technique for minimally or moderately displaced fractured mandible and had better clinical outcomes than did patients that underwent the Erich arch bar technique. (Source: Oral and Maxillofacial Surgery)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OMP0HS

Specialized pro ‐resolving lipid mediators in experimental periodontitis: A systematic review

Oral Diseases, EarlyView. (Source: Oral Diseases)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2CzuDrE

Specialized pro ‐resolving lipid mediators in experimental periodontitis: A systematic review

Oral Diseases, EarlyView. (Source: Oral Diseases)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2CzuDrE

Epilepsy in patients with long QT syndrome type 1: A Norwegian family

We present a Norwegian family with mutations within the KCNQ1 gene causing cLQTS type 1 (LQT1) and epilepsy. The index patient had Jervell and Lange-Nielsen-syndrome (JLNS) with deafness and recurrent episodes of cardiac arrhythmia. The mother and the brother have Romano-Ward syndrome (RWS) with recurrent arrhythmias. Whereas the father has focal epilepsy and genetically verified LQT1, the sister has both focal epilepsy and RWS.Our findings are consistent with the notion that mutations in the KCNQ1 gene can cause epilepsy. (Source: Epilepsy and Behavior Case Reports)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2IMo99s

Losing silence, gaining acceptance: a qualitative exploration of the role of thoughts in adult patients with subjective tinnitus

. (Source: International Journal of Audiology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2pM1GjU

Epilepsy in patients with long QT syndrome type 1: A Norwegian family

We present a Norwegian family with mutations within the KCNQ1 gene causing cLQTS type 1 (LQT1) and epilepsy. The index patient had Jervell and Lange-Nielsen-syndrome (JLNS) with deafness and recurrent episodes of cardiac arrhythmia. The mother and the brother have Romano-Ward syndrome (RWS) with recurrent arrhythmias. Whereas the father has focal epilepsy and genetically verified LQT1, the sister has both focal epilepsy and RWS.Our findings are consistent with the notion that mutations in the KCNQ1 gene can cause epilepsy. (Source: Epilepsy and Behavior Case Reports)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2IMo99s

Losing silence, gaining acceptance: a qualitative exploration of the role of thoughts in adult patients with subjective tinnitus

. (Source: International Journal of Audiology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2pM1GjU

[Possibilities for residual hearing preservation with Nucleus CI532 Slim Modiolar electrode array. Case report].

Authors: Nagy R, Jarabin JA, Dimák B, Perényi Á, Tóth F, Szűts V, Jóri J, Kiss JG, Rovó L Abstract During the rehabilitation of hearing-impaired patients, the preservation of residual acoustic hearing following cochlear implantation by minimizing the implantation trauma allows for improved hearing performance. To achieve this, minimally invasive, soft surgery methods and thinner, atraumatic electrodes were required. In our present study, we reported a case where Cochlear® Nucleus CI532 Slim Modiolar electrode was implanted in a patient with residual hearing. Our aim was to study the possible preservation of postoperative acoustic residual hearing by audiological monitoring. Since childhood, due to her congenital hearing loss, she has been wearing a conventional, airborne he...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2INo4Ci

Impact of bisphosphonate therapy on dental implant outcomes: An overview of systematic review evidence

The purpose of this overview was to assess the methods, quality, and outcomes of systematic reviews conducted to evaluate the impact of bisphosphonates on dental implants and the risk of developing bisphosphonate-related osteonecrosis of the jaw after dental implant surgery. An electronic search without date or language restriction was performed in the PubMed/MEDLINE, Cochrane CENTRAL, Web of Science, and LILACS databases (to January 2018). Eligibility criteria included systematic reviews that evaluated the impact of bisphosphonates on implant outcomes.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2C5F5Gk

Does methylprednisolone improve postoperative outcomes after mandibular third molar surgery? A systematic review and meta-analysis

This systematic review and meta-analysis was performed to investigate whether methylprednisolone (MP) administered via any route improves postoperative outcomes (pain, trismus, and oedema) following mandibular third molar surgery. An electronic search of the PubMed, Scopus, Cochrane CENTRAL, and Google Scholar databases was performed to identify studies published in English up until January 2018. A total of 28 studies were included in the review: 25 randomized clinical trials (RCTs) and three controlled clinical trials.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2CA5sp5

Three-dimensional longitudinal evaluation of facial mimicry in orthognathic class III surgery

The effect of bimaxillary orthognathic surgery on facial mimicry was assessed longitudinally in 15 patients with dentoskeletal class III facial dysmorphism (seven men, eight women, mean age 28 years). The patients were analysed pre-surgery and at 6, 12, and 24 months post-surgery while performing verbal (five vowels) and non-verbal (open and closed mouth smile, lip purse) soft tissue facial movements. The three-dimensional motions of right and left nasogenian, crista philtri, cheilion, and lower lip landmarks were detected by an optoelectronic instrument, and a total mobility index was obtained.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2C5YYgB

The Antitumor Activity of Combinations of Cytotoxic Chemotherapy and Immune Checkpoint Inhibitors Is Model-Dependent

Chlo é Grasselly, Morgane Denis, Aurore Bourguignon, Nolan Talhi, Doriane Mathe, Anne Tourette, Laurent Serre, Lars Petter Jordheim, Eva Laure Matera, Charles Dumontet (Source: Frontiers in Immunology)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2NxzB9m

The simple 10-item PARC tool to predict childhood asthma – an external validation

ConclusionPerforming equally well in the validation cohort as in the development cohort, PARC is a valid tool for predicting asthma in population based cohorts. Its use in clinical practice is ready to be tested. (Source: The Journal of Allergy and Clinical Immunology: In Practice)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Nxztqo

The Impact of Tree Nut Oral Food Challenges on Quality of Life and Acute Reactions in Nut Allergic Patients

Publication date: Available online 9 October 2018Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Jennifer A. Dantzer, Robert A. Wood (Source: The Journal of Allergy and Clinical Immunology: In Practice)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2ONybwi

Does Obesity Increase Respiratory Tract Infections in Patients with Asthma?

ConclusionsBMI classification was not associated with increased risk of RTIs in children or adults. In adults only, obesity was associated with increased URI severity and all-cause and RTI-associated asthma morbidity. (Source: The Journal of Allergy and Clinical Immunology: In Practice)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Nxhf8M

Periodontal ligament fibroblasts migration injury via ROS/TXNIP/Nlrp3 inflammasome pathway with Porphyromonas gingivalis lipopolysaccharide

In conclusion, our results demonstrate that ROS/TXNIP/Nlrp3 Inflammasome pathway is a key initiating mechanism necessary for P.g-LPS-induced subsequent mPDLFs inflammatory response leading to chronic periodontitis. (Source: Molecular Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OQtoKu

Potential advantages of CD1-restricted T cell immunotherapy in cancer

Publication date: November 2018Source: Molecular Immunology, Volume 103Author(s): Michela Consonni, Paolo Dellabona, Giulia CasoratiAbstractAdoptive cell therapy (ACT) using tumor-specific "conventional" MHC-restricted T cells obtained from tumor-infiltrating lymphocytes, or derived ex vivo by either antigen-specific expansion or genetic engineering of polyclonal T cell populations, shows great promise for cancer treatment. However, the wide applicability of this therapy finds limits in the high polymorphism of MHC molecules that restricts the use in the autologous context. CD1 antigen presenting molecules are nonpolymorphic and specialized for lipid antigen presentation to T cells. They are often expressed on malignant cells and, therefore, may represent an attractive target for ACT. ...

MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2NwayDO

CD8+ T Cell Priming in Established Chronic Viral Infection Preferentially Directs Differentiation of Memory-like Cells for Sustained Immunity

How new T  cell responses are mounted during chronic infection is unclear. Snell et al. demonstrate that unlike T cells primed at the onset of infection, CD8+ T cells primed after chronic viral infection is established are differentially programmed into less exhausted, TCF1+ memory-like cells that respond better to immunotherapy but diminish immunity to cancers that arise in chronic infection. (Source: Immunity)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OMpN06

Distinct Effector B Cells Induced by Unregulated Toll-like Receptor 7 Contribute to Pathogenic Responses in Systemic Lupus Erythematosus

The role of extrafollicular B cells in human systemic lupus is unknown. Jenks et  al. define the main components of this pathway and its prominence in severe disease. Its activation is mediated by hyper-responsiveness to Toll-like receptor-7 and leads to the generation of autoreactive antibody-secreting plasmablasts. (Source: Immunity)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Nyjtoh

The Majority of CD45 – Ter119– CD31– Bone Marrow Cell Fraction Is of Hematopoietic Origin and Contains Erythroid and Lymphoid Progenitors

Bone marrow triple-negative CD45 – Ter119– CD31– cells are thought to contain heterogeneous stromal cell populations. Boulais et al. show these cells are mostly hematopoietic in origin and contain previously unappreciated stromal-associated erythroid and B-lymphoid progenitor populations. (Source: Immunity)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2NxQAJ0

The simple 10-item PARC tool to predict childhood asthma – an external validation

ConclusionPerforming equally well in the validation cohort as in the development cohort, PARC is a valid tool for predicting asthma in population based cohorts. Its use in clinical practice is ready to be tested. (Source: The Journal of Allergy and Clinical Immunology: In Practice)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Nxztqo

Human Microbiome: Composition and Role in Inflammatory Skin Diseases

AbstractThis review focuses on recent evidences about human microbiome composition and functions, exploring the potential implication of its impairment in some diffuse and invalidating inflammatory skin diseases, such as atopic dermatitis, psoriasis, hidradenitis suppurativa and acne. We analysed current scientific literature, focusing on the current evidences about gut and skin microbiome composition and the complex dialogue between microbes and the host. Finally, we examined the consequences of this dialogue for health and skin diseases. This review highlights how human microbes interact with different anatomic niches modifying the state of immune activation, skin barrier status, microbe –host and microbe–microbe interactions. It also shows as most of the factors affecting gut and sk...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2NsYqU9

The Impact of Tree Nut Oral Food Challenges on Quality of Life and Acute Reactions in Nut Allergic Patients

Publication date: Available online 9 October 2018Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Jennifer A. Dantzer, Robert A. Wood (Source: The Journal of Allergy and Clinical Immunology: In Practice)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2ONybwi

Innate lymphoid cells in lung infection and immunity

Immunological Reviews,Volume 286, Issue 1, Page 102-119, November 2018. (Source: Immunological Reviews)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OVa8Md

Spatial and temporal coordination of antiviral responses by group 1 ILCs

Immunological Reviews,Volume 286, Issue 1, Page 23-36, November 2018. (Source: Immunological Reviews)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Ny8awf

Periodontal ligament fibroblasts migration injury via ROS/TXNIP/Nlrp3 inflammasome pathway with Porphyromonas gingivalis lipopolysaccharide

In conclusion, our results demonstrate that ROS/TXNIP/Nlrp3 Inflammasome pathway is a key initiating mechanism necessary for P.g-LPS-induced subsequent mPDLFs inflammatory response leading to chronic periodontitis. (Source: Molecular Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OQtoKu

Deconstructing deployment of the innate immune lymphocyte army for barrier homeostasis and protection

Immunological Reviews,Volume 286, Issue 1, Page 6-22, November 2018. (Source: Immunological Reviews)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OMk1LR

Potential advantages of CD1-restricted T cell immunotherapy in cancer

Publication date: November 2018Source: Molecular Immunology, Volume 103Author(s): Michela Consonni, Paolo Dellabona, Giulia CasoratiAbstractAdoptive cell therapy (ACT) using tumor-specific "conventional" MHC-restricted T cells obtained from tumor-infiltrating lymphocytes, or derived ex vivo by either antigen-specific expansion or genetic engineering of polyclonal T cell populations, shows great promise for cancer treatment. However, the wide applicability of this therapy finds limits in the high polymorphism of MHC molecules that restricts the use in the autologous context. CD1 antigen presenting molecules are nonpolymorphic and specialized for lipid antigen presentation to T cells. They are often expressed on malignant cells and, therefore, may represent an attractive target for ACT. ...

MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2NwayDO

CD8+ T Cell Priming in Established Chronic Viral Infection Preferentially Directs Differentiation of Memory-like Cells for Sustained Immunity

How new T  cell responses are mounted during chronic infection is unclear. Snell et al. demonstrate that unlike T cells primed at the onset of infection, CD8+ T cells primed after chronic viral infection is established are differentially programmed into less exhausted, TCF1+ memory-like cells that respond better to immunotherapy but diminish immunity to cancers that arise in chronic infection. (Source: Immunity)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OMpN06

Neuroendocrine regulation of innate lymphoid cells

Immunological Reviews,Volume 286, Issue 1, Page 120-136, November 2018. (Source: Immunological Reviews)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OMpAKm

Distinct Effector B Cells Induced by Unregulated Toll-like Receptor 7 Contribute to Pathogenic Responses in Systemic Lupus Erythematosus

The role of extrafollicular B cells in human systemic lupus is unknown. Jenks et  al. define the main components of this pathway and its prominence in severe disease. Its activation is mediated by hyper-responsiveness to Toll-like receptor-7 and leads to the generation of autoreactive antibody-secreting plasmablasts. (Source: Immunity)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Nyjtoh

The group 2 innate lymphoid cell (ILC2) regulatory network and its underlying mechanisms

Immunological Reviews,Volume 286, Issue 1, Page 37-52, November 2018. (Source: Immunological Reviews)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Nw9qjv

JAK/STAT signaling in regulation of innate lymphoid cells: The gods before the guardians

Immunological Reviews,Volume 286, Issue 1, Page 148-159, November 2018. (Source: Immunological Reviews)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OT8tXu

The Majority of CD45 – Ter119– CD31– Bone Marrow Cell Fraction Is of Hematopoietic Origin and Contains Erythroid and Lymphoid Progenitors

Bone marrow triple-negative CD45 – Ter119– CD31– cells are thought to contain heterogeneous stromal cell populations. Boulais et al. show these cells are mostly hematopoietic in origin and contain previously unappreciated stromal-associated erythroid and B-lymphoid progenitor populations. (Source: Immunity)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2NxQAJ0

TGF ‐β suppresses RasGRP1 expression and supports regulatory T cell resistance against p53‐induced CD28‐dependent T cell apoptosis

European Journal of Immunology,Volume 0, Issue ja, -Not available-. (Source: European Journal of Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OMGKrm

Human Microbiome: Composition and Role in Inflammatory Skin Diseases

AbstractThis review focuses on recent evidences about human microbiome composition and functions, exploring the potential implication of its impairment in some diffuse and invalidating inflammatory skin diseases, such as atopic dermatitis, psoriasis, hidradenitis suppurativa and acne. We analysed current scientific literature, focusing on the current evidences about gut and skin microbiome composition and the complex dialogue between microbes and the host. Finally, we examined the consequences of this dialogue for health and skin diseases. This review highlights how human microbes interact with different anatomic niches modifying the state of immune activation, skin barrier status, microbe –host and microbe–microbe interactions. It also shows as most of the factors affecting gut and sk...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2NsYqU9

Innate lymphoid cells in lung infection and immunity

Immunological Reviews,Volume 286, Issue 1, Page 102-119, November 2018. (Source: Immunological Reviews)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OVa8Md

Spatial and temporal coordination of antiviral responses by group 1 ILCs

Immunological Reviews,Volume 286, Issue 1, Page 23-36, November 2018. (Source: Immunological Reviews)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Ny8awf

Deconstructing deployment of the innate immune lymphocyte army for barrier homeostasis and protection

Immunological Reviews,Volume 286, Issue 1, Page 6-22, November 2018. (Source: Immunological Reviews)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OMk1LR

New insights into the function, development, and plasticity of type 2 innate lymphoid cells

Immunological Reviews,Volume 286, Issue 1, Page 74-85, November 2018. (Source: Immunological Reviews)

MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2NyKmZ6

Neuroendocrine regulation of innate lymphoid cells

Immunological Reviews,Volume 286, Issue 1, Page 120-136, November 2018. (Source: Immunological Reviews)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OMpAKm

The group 2 innate lymphoid cell (ILC2) regulatory network and its underlying mechanisms

Immunological Reviews,Volume 286, Issue 1, Page 37-52, November 2018. (Source: Immunological Reviews)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Nw9qjv

JAK/STAT signaling in regulation of innate lymphoid cells: The gods before the guardians

Immunological Reviews,Volume 286, Issue 1, Page 148-159, November 2018. (Source: Immunological Reviews)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OT8tXu

Comparison of Erich arch bar versus embrasure wires for intraoperative intermaxillary fixation in mandibular fractures

Abstract

Purpose

Intermaxillary fixation (IMF) is a fundamental principle in the management of mandibular fractures but with recent advent of open reduction and internal fixation (ORIF), use of IMF is almost limited intraoperatively. Therefore, we compared the efficacy of Erich arch bar versus embrasure wires for intraoperative IMF in mandibular fractures.

Method

This prospective study was comprised of 50 patients with mandibular fractures who required ORIF with intraoperative IMF. Patients were categorized into two groups of 25 patients each: Erich arch bar technique was used for group A and embrasure wire technique for group B. Parameters were time taken for IMF, needle stick injury, occlusal stability, iatrogenic complications, and periodontal status of patients.

Statistical analysis

Chi-squared test and unpaired t test analyses was run on IBM SPSS 21.0 version (2015) software.

Result

Mean time for placing embrasure wire (3.48 min) was significantly less than that for Erich arch bar (48.08 min). Needle stick injury rates to the operator as well as the assistants were significantly less when using the embrasure wire than the Erich arch bar. The Erich arch bar had significantly superior postoperative occlusion stability. Iatrogenic injury was more common when placing the Erich arch bar than the embrasure wire. Postoperative oral hygiene status was good in patients that received the embrasure wire.

Conclusion

Embrasure wire technique is a quick, easy, and reliable technique for minimally or moderately displaced fractured mandible and had better clinical outcomes than did patients that underwent the Erich arch bar technique.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2C3Bclg

Comparison of Erich arch bar versus embrasure wires for intraoperative intermaxillary fixation in mandibular fractures

Abstract

Purpose

Intermaxillary fixation (IMF) is a fundamental principle in the management of mandibular fractures but with recent advent of open reduction and internal fixation (ORIF), use of IMF is almost limited intraoperatively. Therefore, we compared the efficacy of Erich arch bar versus embrasure wires for intraoperative IMF in mandibular fractures.

Method

This prospective study was comprised of 50 patients with mandibular fractures who required ORIF with intraoperative IMF. Patients were categorized into two groups of 25 patients each: Erich arch bar technique was used for group A and embrasure wire technique for group B. Parameters were time taken for IMF, needle stick injury, occlusal stability, iatrogenic complications, and periodontal status of patients.

Statistical analysis

Chi-squared test and unpaired t test analyses was run on IBM SPSS 21.0 version (2015) software.

Result

Mean time for placing embrasure wire (3.48 min) was significantly less than that for Erich arch bar (48.08 min). Needle stick injury rates to the operator as well as the assistants were significantly less when using the embrasure wire than the Erich arch bar. The Erich arch bar had significantly superior postoperative occlusion stability. Iatrogenic injury was more common when placing the Erich arch bar than the embrasure wire. Postoperative oral hygiene status was good in patients that received the embrasure wire.

Conclusion

Embrasure wire technique is a quick, easy, and reliable technique for minimally or moderately displaced fractured mandible and had better clinical outcomes than did patients that underwent the Erich arch bar technique.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2C3Bclg

Comparison of Erich arch bar versus embrasure wires for intraoperative intermaxillary fixation in mandibular fractures

Abstract

Purpose

Intermaxillary fixation (IMF) is a fundamental principle in the management of mandibular fractures but with recent advent of open reduction and internal fixation (ORIF), use of IMF is almost limited intraoperatively. Therefore, we compared the efficacy of Erich arch bar versus embrasure wires for intraoperative IMF in mandibular fractures.

Method

This prospective study was comprised of 50 patients with mandibular fractures who required ORIF with intraoperative IMF. Patients were categorized into two groups of 25 patients each: Erich arch bar technique was used for group A and embrasure wire technique for group B. Parameters were time taken for IMF, needle stick injury, occlusal stability, iatrogenic complications, and periodontal status of patients.

Statistical analysis

Chi-squared test and unpaired t test analyses was run on IBM SPSS 21.0 version (2015) software.

Result

Mean time for placing embrasure wire (3.48 min) was significantly less than that for Erich arch bar (48.08 min). Needle stick injury rates to the operator as well as the assistants were significantly less when using the embrasure wire than the Erich arch bar. The Erich arch bar had significantly superior postoperative occlusion stability. Iatrogenic injury was more common when placing the Erich arch bar than the embrasure wire. Postoperative oral hygiene status was good in patients that received the embrasure wire.

Conclusion

Embrasure wire technique is a quick, easy, and reliable technique for minimally or moderately displaced fractured mandible and had better clinical outcomes than did patients that underwent the Erich arch bar technique.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2C3Bclg

EpiPen Shortage Keeping Some Kids Out Of School

(CBS News) — Eden Morris should be in kindergarten with his friends but the 5-year-old has been home since the school year started. Eden has severe allergies so Spanaway Elementary, about 35 miles south of Seattle, won't let him go to school without an EpiPen. The U.S. is experiencing a shortage of the lifesaving device and parents are scrambling to find them because some schools won't let kids with allergies in the classroom if they don't have one. This affects as many as two students in every classroom in the U.S. "There's nothing else that made me feel worse than my son telling me, 'Mom, why can't I go to school? Why am I different from other kids?'" Eden's mom, Chiquita, told CBS News' John Blackstone. Related: First G...

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2C5oYsk

Schools shut doors to kids with severe allergies who can't get EpiPen amid national shortage

Chiquita Morris said her five-year-old son Eden was sent home on his first day of kindergarten at Spanaway Elementary School in Spanaway, Washington, because he didn't have an EpiPen. (Source: the Mail online | Health)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2CA1lte

Yes-associated protein (YAP) molecule expression in odontogenic epithelium of ameloblastoma

Abstract

Objectives

YAP (Yes-associated protein molecule) augments multiple processes known to be important for tumor progression and metastasis. Hence, the application of YAP as a targeted therapy for several malignancies has been documented in the literature. Ameloblastoma being a locally invasive odontogenic lesion causes tissue destruction and presents with a great chance of recurrence. Based on these qualities, we hypothesized that YAP could exhibit increased expression in the odontogenic epithelium of ameloblastoma. Therefore, the objective of the present study was to evaluate the immunohistochemical expression of YAP in ameloblastoma and compare the immunoreactivity of YAP in ameloblastoma and dental follicle.

Materials and methods

Twenty-four paraffin-embedded tissue blocks of ameloblastoma and dental follicle each were retrieved from the departmental archives. Immunohistochemical (IHC) staining was performed employing YAP antibody on 5-μm thick sections. The expression of YAP was reviewed on the peripheral lining of ameloblast-like cells and centrally placed stellate reticulum–like cells and was further graded as negative, weak, or strong. For data analysis, Chi-square test and Fisher's exact test were applied.

Results

In ameloblastoma, peripheral/basal cells exhibited strong expression for YAP in 12/24 cases and weak expression in the other 12 cases. Whereas, 20 cases of dental follicle presented negative expression and only four cases exhibited weak expression (p < 0.001). On statistical analysis, the differences in expression of YAP in stellate cells of ameloblastoma and dental follicle were found to be significant (p < 0.001).

Conclusion

YAP expression was strongly seen in ameloblastoma as compared to the epithelial islands of dental follicle. The neoplastic nature of ameloblastoma could be attributed to YAP molecule and it may play a possible role in tumor invasiveness.

Clinical relevance

Positive YAP expression in ameloblastoma and negative expression in the odontogenic epithelial islands of dental follicle insinuate that YAP could be responsible for the aggressiveness and local tissue invasion commonly encountered with ameloblastoma.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Ebh7wl

Alveolar bone preservation by a hydroxyapatite/collagen composite material after tooth extraction

Abstract

Objective

The aim of this study was to assess the effectiveness of a hydroxyapatite/collagen composite material (HAp/Col) for preservation of alveolar bone after tooth extraction.

Materials and methods

HAp/Col was applied to the alveolus bone ridge preservation after tooth extraction, because of subsequent dental implant placement in 35 regions of 24 patients (mean age, 59.3 years; range, 25–81 years). Cone beam computed tomography was used to assess changes in alveolar bone at the extraction site before and at 3 months (mean, 13.7 weeks; range, 10–17 weeks) after tooth extraction. Changes in height and width of the alveolar bone were measured to evaluate bone reduction after surgery. Bone biopsy was performed at 11 regions of dental implant placement to observe bone regeneration and remaining material in the extraction socket.

Results

The alveolar bone height was decreased by 0.00 ± 2.44 mm at the buccal side and 0.35 ± 1.73 mm at the lingual side, while the width was decreased by 1.02 ± 1.64 mm at 3 months after surgery. The middle of the socket floor was elevated by 5.71 ± 3.45 mm at 3 months after surgery. Bone biopsy specimens revealed no remaining implanted material, and approximately 49.79 ± 14.41% of the specimens were occupied by bone tissue.

Conclusions

According to the result of this study, HAp/Col is a reliable material to presearve alveolar bone after tooth extraction.

Clinical relevance

HAp/Col contributes dental implant treatment due to maintain the alveolar bone after tooth extraction.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OM9DDP

Presentation of gaps around endodontic access cavity restoration by phase contrast-enhanced micro-CT

Abstract

Objective

To evaluate the feasibility of synchrotron-based phase-contrast (PC) μCT for visualization of the gaps and differentiation between the gaps, restorative, and endodontic materials at the tooth-restoration interface.

Materials and methods

Standardized access cavities were prepared in human maxillary molars and subjected to materials, simulating endodontic treatment: (1) saline irrigation; (2) NaOCl and 17% EDTA irrigation; (3) same as group 2, followed by application of Ca(OH)₂; and (4) same as group 2, followed by application of root canal sealer. The access cavities were cleaned and restored using an etch-and-rinse adhesive and a composite material in multilayering technique. The samples were thermocycled (1000 cycles, 5–55 °C). Synchrotron-based μCT imaging was performed obtaining absorption and PC μCT images before and after the immersion of the samples into 50% AgNO₃. PC μCT images were compared to absorption μCT and conventional optical microscopy images.

Results

PC μCT of unstained samples enabled the best visualization of gaps and differentiation of restorative and endodontic materials, contaminating the cavity surface. PC μCT revealed that AgNO₃ staining leads to an overestimation of gap size due to anterograde and retrograde AgNO₃ infiltration into dentinal tubules and underestimation of large gaps due to lack of AgNO₃ penetration.

Conclusion

Synchrotron PC μCT imaging enables better visualization of gap and differentiation of materials at the tooth-restoration interface. μCT imaging with AgNO3 staining has shown certain over- and underestimations. Future research should be aimed at incorporating PC μCT imaging of unstained samples for the validation of results obtained with other methods.

Clinical significance

Contamination of cavity walls with an endodontic sealer or Ca(OH)₂ leads to increased gap formation at the tooth-restoration interface.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2RCirLd

Comparative evaluation of autofluorescence imaging and histopathological investigation for oral potentially malignant disorders in Taiwan

Abstract

Objectives

Autofluorescence imaging is gaining popularity as an adjunctive test for oral potentially malignant disorders (OPMD). This study evaluated the efficacy of autofluorescence imaging based on the current standard oral mucosal disorder checklist in Taiwan.

Materials and methods

In total, 126 patients suspected to have mucosal disorders at the Division of Oral and Maxillofacial Surgery, Tri-Service General Hospital, Taipei, Taiwan, were enrolled. Following a conventional oral examination by using the oral mucosal disorder checklist and an autofluorescence imaging examination, all participants underwent histopathological examination to access epithelial dysplasia.

Results

Among 126 patients, 68 patients were diagnosis as having an OPMD and 63 having epithelial dysplasia. Autofluorescence imaging exhibited a sensitivity, specificity, positivity predictive value (PPV), negative predictive value (NPV), and accuracy of 77.94%, 35.42%, 63.10%, 53.13%, and 60.34%, respectively, for OPMD and of 88.89%, 43.86%, 63.64%, 78.13%, and 67.50%, respectively, for epithelial dysplasia. After the exclusion of 48 non-OPMD cases according to the checklist, the sensitivity, specificity, PPV, NPV, and accuracy of autofluorescence imaging became 87.50%, 72.73%, 94.23%, 53.33%, and 85.07%, respectively, for epithelial dysplasia.

Conclusion

The efficacy of epithelial dysplasia identification and OPMD risk assessment can be increased after the exclusion of the non-OPMD cases through autofluorescence imaging.

Clinical relevance

Autofluorescence imaging is a useful adjunct that can assist specialists in assessing OPMD patients prone to dysplasia without compromising patient care.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2E7qe0V

Comparing the outcomes of gold-standard dental examinations with photographic screening by mid-level dental providers

Abstract

Objectives

To determine the detectability of the intra-oral photographic method in comparison to the baseline, comprehensive dental examination (CDE), in children when performed by different levels of dental practitioners.

Materials and methods

As part of a quality assurance program, intra-oral photographs were obtained from 77 patients (2–18 years) as part of a CDE before undertaking dental treatment under general anaesthesia. A DSLR camera was utilised to acquire images which were subsequently uploaded to a cloud-based server. The baseline for each participant was established during the CDE, utilising both visual and radiographic examination, which was then compared to the assessment made by a mid-level dental practitioners (MLDP). The evaluation was based on utilising an odontogram where the teeth were charted either as decayed or filled.

Results

Specificity (95%) was higher than sensitivity (61.5%) when comparing the photographic assessment with the benchmark CDE assessment. The inter-rater reliability between the two methods of assessment was substantial, with a kappa score of 0.62. The photographic assessment method underestimated the decayed and filled teeth, as observed by the caries experience (dft/DFT scores) (CDE = 7.01 vs. photographic assessment = 5.22). There were lower levels of diagnostic detection in the posterior teeth as compared to the anterior teeth assessments.

Conclusions

Although the CDE is still considered to be the gold-standard, this study found that the photographic caries assessment by MLDP produced an acceptable diagnostic level of detection particularly for the anterior teeth.

Clinical relevance

The photographic method could offer a potential cost-saving and user-friendly screening.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2RFrESO

EpiPen Shortage Keeping Some Kids Out Of School

(CBS News) — Eden Morris should be in kindergarten with his friends but the 5-year-old has been home since the school year started. Eden has severe allergies so Spanaway Elementary, about 35 miles south of Seattle, won't let him go to school without an EpiPen. The U.S. is experiencing a shortage of the lifesaving device and parents are scrambling to find them because some schools won't let kids with allergies in the classroom if they don't have one. This affects as many as two students in every classroom in the U.S. "There's nothing else that made me feel worse than my son telling me, 'Mom, why can't I go to school? Why am I different from other kids?'" Eden's mom, Chiquita, told CBS News' John Blackstone. Related: First G...

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2C5oYsk