Optimal protection against Salmonella infection requires noncirculating memory [Immunology and Inflammation]

While CD4 Th1 cells are required for resistance to intramacrophage infections, adoptive transfer of Th1 cells is insufficient to protect against Salmonella infection. Using an epitope-tagged vaccine strain of Salmonella, we found that effective protection correlated with expanded Salmonella-specific memory CD4 T cells in circulation and nonlymphoid tissues. However, naive... (Source: Proceedings of the National Academy of Sciences)

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