Distinct Effector B Cells Induced by Unregulated Toll-like Receptor 7 Contribute to Pathogenic Responses in Systemic Lupus Erythematosus

The role of extrafollicular B cells in human systemic lupus is unknown. Jenks et  al. define the main components of this pathway and its prominence in severe disease. Its activation is mediated by hyper-responsiveness to Toll-like receptor-7 and leads to the generation of autoreactive antibody-secreting plasmablasts. (Source: Immunity)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Nyjtoh