Σάββατο 8 Σεπτεμβρίου 2018

STAT5B deficiency due to a novel missense mutation in the coiled-coil domain

A novel homozygous missense mutation in the coiled-coil domain of STAT5B causes an immunodeficiency syndrome characterised by short stature due to GH insensitivity, immune dysregulation and hypothyroidism but currently without pulmonary disease or T-cell lymphopenia. (Source: Journal of Allergy and Clinical Immunology)

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Tobacco smoke as a risk factor for allergic sensitization in adults: conclusions of a systematic review and meta-analysis

(Source: Journal of Allergy and Clinical Immunology)

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Differential expression of functional chemokine receptors on human blood and lung group 2 innate lymphoid cells (ILC2s)

Differential expression of chemokine receptors on lymphocytes enables tissue and disease specific recruitment and activation of various lymphocytes. We have shown that human ILC2s display a different subset of functional chemokine receptors when isolated from blood or lung tissue. (Source: Journal of Allergy and Clinical Immunology)

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Lower Perinatal Exposure to Proteobacteria is an Independent Predictor of Early Childhood Wheezing

Circulating free Proteobacterial DNA in umbilical cord serum is associated with features of childhood asthma including maternal atopy, early childhood wheezing, and bronchodilator response. (Source: Journal of Allergy and Clinical Immunology)

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Anti-IL5 treatments in severe asthma by blood eosinophil thresholds: indirect treatment comparison

In the absence of head-to-head comparisons, this indirect treatment comparison provides clinically relevant, comparative information on the efficacy of licensed formulations of the three approved anti-IL5 pathway therapies in SEA by baseline blood eosinophil count. (Source: Journal of Allergy and Clinical Immunology)

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Tobacco smoke as a risk factor for allergic sensitization in adults: conclusions of a systematic review and meta-analysis

(Source: Journal of Allergy and Clinical Immunology)

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Differential expression of functional chemokine receptors on human blood and lung group 2 innate lymphoid cells (ILC2s)

Differential expression of chemokine receptors on lymphocytes enables tissue and disease specific recruitment and activation of various lymphocytes. We have shown that human ILC2s display a different subset of functional chemokine receptors when isolated from blood or lung tissue. (Source: Journal of Allergy and Clinical Immunology)

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Lower Perinatal Exposure to Proteobacteria is an Independent Predictor of Early Childhood Wheezing

Circulating free Proteobacterial DNA in umbilical cord serum is associated with features of childhood asthma including maternal atopy, early childhood wheezing, and bronchodilator response. (Source: Journal of Allergy and Clinical Immunology)

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Anti-IL5 treatments in severe asthma by blood eosinophil thresholds: indirect treatment comparison

In the absence of head-to-head comparisons, this indirect treatment comparison provides clinically relevant, comparative information on the efficacy of licensed formulations of the three approved anti-IL5 pathway therapies in SEA by baseline blood eosinophil count. (Source: Journal of Allergy and Clinical Immunology)

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Management of osteoradionecrosis of the jaws with pentoxifylline –tocopherol: a systematic review of the literature and meta-analysis

Osteoradionecrosis (ORN) of the jaws remains among the most commonly encountered and challenging complications of radiotherapy to the head and neck. The purpose of this study was to provide a review of the medical management for ORN and evaluate the reported outcomes with the use of pentoxifylline and tocopherol (PENTO), by means of a systematic review and meta-analysis. The predictor variable was the use of PENTO in the treatment of ORN. The outcome variable was the proportion of full recovery or significant improvement not requiring further intervention. (Source: International Journal of Oral and Maxillofacial Surgery)

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Relationship of age to foramen of Huschke and investigation of the development of spontaneous temporomandibular joint herniation

The aim of this study was to determine the prevalence, localization, and width of the foramen of Huschke (FH) and the relationship between age and FH. Another aim was to investigate the development of spontaneous temporomandibular joint (TMJ) herniation. This was a retrospective review of high-resolution computed tomography images of the temporal bone of 1025 patients. The prevalence of FH and the axial and sagittal diameters of the foramen were evaluated. Cases were found in which the TMJ had herniated through FH into the EAC. (Source: International Journal of Oral and Maxillofacial Surgery)

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Management of osteoradionecrosis of the jaws with pentoxifylline –tocopherol: a systematic review of the literature and meta-analysis

Osteoradionecrosis (ORN) of the jaws remains among the most commonly encountered and challenging complications of radiotherapy to the head and neck. The purpose of this study was to provide a review of the medical management for ORN and evaluate the reported outcomes with the use of pentoxifylline and tocopherol (PENTO), by means of a systematic review and meta-analysis. The predictor variable was the use of PENTO in the treatment of ORN. The outcome variable was the proportion of full recovery or significant improvement not requiring further intervention. (Source: International Journal of Oral and Maxillofacial Surgery)

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Relationship of age to foramen of Huschke and investigation of the development of spontaneous temporomandibular joint herniation

The aim of this study was to determine the prevalence, localization, and width of the foramen of Huschke (FH) and the relationship between age and FH. Another aim was to investigate the development of spontaneous temporomandibular joint (TMJ) herniation. This was a retrospective review of high-resolution computed tomography images of the temporal bone of 1025 patients. The prevalence of FH and the axial and sagittal diameters of the foramen were evaluated. Cases were found in which the TMJ had herniated through FH into the EAC. (Source: International Journal of Oral and Maxillofacial Surgery)

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The use of intra-articular analgesics to improve outcomes after temporomandibular joint arthrocentesis: a review

ConclusionsThere is inconclusive evidence in literature on the benefits of using intra-articular analgesics after TMJ arthrocentesis. Well-designed high-quality RCTs with standard protocol studying the effects of intra-articular opioids and NSAIDS after TMJ arthrocentesis would provide stronger evidence on its use. (Source: Oral and Maxillofacial Surgery)

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The use of intra-articular analgesics to improve outcomes after temporomandibular joint arthrocentesis: a review

ConclusionsThere is inconclusive evidence in literature on the benefits of using intra-articular analgesics after TMJ arthrocentesis. Well-designed high-quality RCTs with standard protocol studying the effects of intra-articular opioids and NSAIDS after TMJ arthrocentesis would provide stronger evidence on its use. (Source: Oral and Maxillofacial Surgery)

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Global Head and Neck cancer (HNC) Market Treatment approaches, Patient Population, Impact of upcoming Therapies ...

Global Head and Neck cancer (HNC) Market Treatment approaches, Patient Population, Impact of upcoming Therapies ...  Daily Industry ReportsFull coverage


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Global Head and Neck cancer (HNC) Market Treatment approaches, Patient Population, Impact of upcoming Therapies ...

Global Head and Neck cancer (HNC) Market Treatment approaches, Patient Population, Impact of upcoming Therapies ...  Daily Industry ReportsFull coverage


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Safest level of alcohol consumption is none, worldwide study shows

Safest level of alcohol consumption is none, worldwide study shows  Washington PostStudy Has Sobering News for Moderate Drinkers  NewserNo safe level of alcohol, scientific study concludes  UW Medicine Newsroom (press release) (blog)The Lancet: Alcohol is associated with 2.8 million deaths each year worldwide  EurekAlert (press release)Full coverage


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Global Thyroid Cancer Market Disease Outlook, Type, Treatment Algorithm along with Treatment Guidelines 2027

Global Thyroid Cancer Market Disease Outlook, Type, Treatment Algorithm along with Treatment Guidelines 2027  Daily Industry ReportsFull coverage


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Global Thyroid Cancer Market Disease Outlook, Type, Treatment Algorithm along with Treatment Guidelines 2027

Global Thyroid Cancer Market Disease Outlook, Type, Treatment Algorithm along with Treatment Guidelines 2027  Daily Industry ReportsFull coverage


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Global Medullary Thyroid Cancer Market: Identify the Drivers, Leaders and barriers of Medullary Thyroid Cancer Market ...

Global Medullary Thyroid Cancer Market: Identify the Drivers, Leaders and barriers of Medullary Thyroid Cancer Market ...  Daily Industry ReportsFull coverage


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Anti-IL5 treatments in severe asthma by blood eosinophil thresholds: indirect treatment comparison

In the absence of head-to-head comparisons, this indirect treatment comparison provides clinically relevant, comparative information on the efficacy of licensed formulations of the three approved anti-IL5 pathway therapies in SEA by baseline blood eosinophil count. (Source: Journal of Allergy and Clinical Immunology)

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STAT5B deficiency due to a novel missense mutation in the coiled-coil domain

A novel homozygous missense mutation in the coiled-coil domain of STAT5B causes an immunodeficiency syndrome characterised by short stature due to GH insensitivity, immune dysregulation and hypothyroidism but currently without pulmonary disease or T-cell lymphopenia. (Source: Journal of Allergy and Clinical Immunology)

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Lower Perinatal Exposure to Proteobacteria is an Independent Predictor of Early Childhood Wheezing

Circulating free Proteobacterial DNA in umbilical cord serum is associated with features of childhood asthma including maternal atopy, early childhood wheezing, and bronchodilator response. (Source: Journal of Allergy and Clinical Immunology)

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Differential expression of functional chemokine receptors on human blood and lung group 2 innate lymphoid cells (ILC2s)

Differential expression of chemokine receptors on lymphocytes enables tissue and disease specific recruitment and activation of various lymphocytes. We have shown that human ILC2s display a different subset of functional chemokine receptors when isolated from blood or lung tissue. (Source: Journal of Allergy and Clinical Immunology)

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Tobacco smoke as a risk factor for allergic sensitization in adults: conclusions of a systematic review and meta-analysis

(Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2wRkqBC

Anti-IL5 treatments in severe asthma by blood eosinophil thresholds: indirect treatment comparison

In the absence of head-to-head comparisons, this indirect treatment comparison provides clinically relevant, comparative information on the efficacy of licensed formulations of the three approved anti-IL5 pathway therapies in SEA by baseline blood eosinophil count. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2wT6qYg

STAT5B deficiency due to a novel missense mutation in the coiled-coil domain

A novel homozygous missense mutation in the coiled-coil domain of STAT5B causes an immunodeficiency syndrome characterised by short stature due to GH insensitivity, immune dysregulation and hypothyroidism but currently without pulmonary disease or T-cell lymphopenia. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2NygrUW

Lower Perinatal Exposure to Proteobacteria is an Independent Predictor of Early Childhood Wheezing

Circulating free Proteobacterial DNA in umbilical cord serum is associated with features of childhood asthma including maternal atopy, early childhood wheezing, and bronchodilator response. (Source: Journal of Allergy and Clinical Immunology)

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Differential expression of functional chemokine receptors on human blood and lung group 2 innate lymphoid cells (ILC2s)

Differential expression of chemokine receptors on lymphocytes enables tissue and disease specific recruitment and activation of various lymphocytes. We have shown that human ILC2s display a different subset of functional chemokine receptors when isolated from blood or lung tissue. (Source: Journal of Allergy and Clinical Immunology)

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Tobacco smoke as a risk factor for allergic sensitization in adults: conclusions of a systematic review and meta-analysis

(Source: Journal of Allergy and Clinical Immunology)

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September Is Thyroid Cancer Awareness Month

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September Is Thyroid Cancer Awareness Month  Newswise (press release)Full coverage


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How not saying 'cancer' for low-risk thyroid cancer may affect treatment preferences, patient anxiety

How not saying 'cancer' for low-risk thyroid cancer may affect treatment preferences, patient anxiety  EurekAlert (press release)Drop the Word 'Cancer,' and Patient Choices Change  HealthDayFull coverage


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Anaplastic Thyroid Cancer Drug | Global market 2018-2023 analysis (Major Players:Daiichi Sankyo Company, Limited ...

Anaplastic Thyroid Cancer Drug | Global market 2018-2023 analysis (Major Players:Daiichi Sankyo Company, Limited ...  LiveBittThyroid Cancer Drugs Market Research Based on Elite Players, Present, Past and Futuristic Data Till 2026  Business StrategiesFull coverage


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September Is Thyroid Cancer Awareness Month

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September Is Thyroid Cancer Awareness Month  Newswise (press release)Full coverage


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How not saying 'cancer' for low-risk thyroid cancer may affect treatment preferences, patient anxiety

How not saying 'cancer' for low-risk thyroid cancer may affect treatment preferences, patient anxiety  EurekAlert (press release)Drop the Word 'Cancer,' and Patient Choices Change  HealthDayFull coverage


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Developing a bilingual mobile dictionary for Indian Sign Language and gathering users experience with SignDict.

This article discusses the development of a bilingual mobile sign language dictionary which has features for converting camera captured text into sign language and translating simple sentences from a spoken language into their corresponding signs. Feedback from 2900 users spread across India who have installed our mobile application indicates that, users prefer mobile application for learning ISL. Comparing the existing printed sign language dictionaries and other mobile based ISL dictionaries with the mobile application we have developed, 45 stakeholders of a deaf school assessed that its features like easy availability, speed of operation and character recognition are very effective in learning Indian Sign Language (ISL). PMID: 30193075 [PubMed - as supplied by publisher] (Source: As...

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Developing a bilingual mobile dictionary for Indian Sign Language and gathering users experience with SignDict.

This article discusses the development of a bilingual mobile sign language dictionary which has features for converting camera captured text into sign language and translating simple sentences from a spoken language into their corresponding signs. Feedback from 2900 users spread across India who have installed our mobile application indicates that, users prefer mobile application for learning ISL. Comparing the existing printed sign language dictionaries and other mobile based ISL dictionaries with the mobile application we have developed, 45 stakeholders of a deaf school assessed that its features like easy availability, speed of operation and character recognition are very effective in learning Indian Sign Language (ISL). PMID: 30193075 [PubMed - as supplied by publisher] (Source: As...

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Anaplastic Thyroid Cancer Drug | Global market 2018-2023 analysis (Major Players:Daiichi Sankyo Company, Limited ...

Anaplastic Thyroid Cancer Drug | Global market 2018-2023 analysis (Major Players:Daiichi Sankyo Company, Limited ...  LiveBittGlobal Castration-Resistant Prostate Cancer (CRPC)/HRPCA Therapeutics Sales Market Report 2018 - Questale  QuestaleFull coverage


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Thyroid Cancer Drugs Market Growth Opportunities and Future Prospects till 2026

Thyroid Cancer Drugs Market Growth Opportunities and Future Prospects till 2026  Business StrategiesGlobal Medullary Thyroid Cancer Market: Identify the Drivers, Leaders and barriers of Medullary Thyroid Cancer Market ...  Daily Industry ReportsFull coverage


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Global Head and Neck cancer (HNC) Market Treatment approaches, Patient Population, Impact of upcoming Therapies ...

Global Head and Neck cancer (HNC) Market Treatment approaches, Patient Population, Impact of upcoming Therapies ...  Daily Industry ReportsFull coverage


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Global Recurrent Head And Neck Cancer Squamous Cell Carcinoma Market: A Study Towards Market Shares ...

Global Recurrent Head And Neck Cancer Squamous Cell Carcinoma Market: A Study Towards Market Shares ...  Daily Industry ReportsFull coverage


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Head and neck cancer: A major disease burden

Head-and-neck-cancer.jpg

Head and neck cancer: A major disease burden  Himalayan TimesGetting ahead of head and neck cancers  Channel NewsAsiaFull coverage


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Marijuana may improve quality of life in head and neck cancer

Marijuana may improve quality of life in head and neck cancer  Medical XpressFull coverage


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إقرار لائحة تعرفة جديدة بالأجور الطبية / تفاصيل

إقرار لائحة تعرفة جديدة بالأجور الطبية / تفاصيل  sawaleif.com25 دينارا الحد الأعلى لكشفية طبيب الاختصاص و12 للعام  johinanews.comFull coverage


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Thyroid Cancer Drugs Market Growth Opportunities and Future Prospects till 2026

Thyroid Cancer Drugs Market Growth Opportunities and Future Prospects till 2026  Business StrategiesGlobal Medullary Thyroid Cancer Market: Identify the Drivers, Leaders and barriers of Medullary Thyroid Cancer Market ...  Daily Industry ReportsFull coverage


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Why The Cancer Death Of A Fukushima Worker Was Likely Not Due To Fukushima

Why The Cancer Death Of A Fukushima Worker Was Likely Not Due To Fukushima  ForbesIn a First, Japan Says Fukushima Radiation Caused Worker's Cancer Death  New York TimesJapan Acknowledges the First Radiation-Linked Death From the Fukushima Nuclear Disaster  TIMEFull coverage


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Global Head and Neck cancer (HNC) Market Treatment approaches, Patient Population, Impact of upcoming Therapies ...

Global Head and Neck cancer (HNC) Market Treatment approaches, Patient Population, Impact of upcoming Therapies ...  Daily Industry ReportsFull coverage


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Global Recurrent Head And Neck Cancer Squamous Cell Carcinoma Market: A Study Towards Market Shares ...

Global Recurrent Head And Neck Cancer Squamous Cell Carcinoma Market: A Study Towards Market Shares ...  Daily Industry ReportsFull coverage


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Head and neck cancer: A major disease burden

Head-and-neck-cancer.jpg

Head and neck cancer: A major disease burden  Himalayan TimesGetting ahead of head and neck cancers  Channel NewsAsiaFull coverage


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Marijuana may improve quality of life in head and neck cancer

Marijuana may improve quality of life in head and neck cancer  Medical XpressFull coverage


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إقرار لائحة تعرفة جديدة بالأجور الطبية / تفاصيل

إقرار لائحة تعرفة جديدة بالأجور الطبية / تفاصيل  sawaleif.com25 دينارا الحد الأعلى لكشفية طبيب الاختصاص و12 للعام  johinanews.comFull coverage


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Global Larynx Cancer Market: A Study Towards Market Shares, Symptoms, Treatment, Strategies and Forecast 2027

Global Larynx Cancer Market: A Study Towards Market Shares, Symptoms, Treatment, Strategies and Forecast 2027  Daily Industry ReportsFull coverage


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Bilateral Panuveitis and Keratitis as First Presentation of Relapsing Polychondritis.

CONCLUSION: Owing to debilitating and even life-threatening consequences of enigmatic relapsing polychondritis, high suspicion of the disease is of paramount importance in cases of retinal vasculitis and uveitis. PMID: 30193073 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)

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Ocular Whipple Disease: Report of Three Cases.

CONCLUSIONS: Whipple disease can have protean manifestations in the eye including an isolated ocular surface involvement manifested as keratitis. PMID: 30192690 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)

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Mucormycosis Endophthalmitis in a Silicone Oil-Filled Eye of an Immunocompetent Patient.

CONCLUSIONS: To the best of our knowledge, this is the first report of mucor endophthalmitis in a silicone oil-filled globe of an immunocompetent patient. PMID: 30192700 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)

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Bilateral Panuveitis and Keratitis as First Presentation of Relapsing Polychondritis.

CONCLUSION: Owing to debilitating and even life-threatening consequences of enigmatic relapsing polychondritis, high suspicion of the disease is of paramount importance in cases of retinal vasculitis and uveitis. PMID: 30193073 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)

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Ocular Whipple Disease: Report of Three Cases.

CONCLUSIONS: Whipple disease can have protean manifestations in the eye including an isolated ocular surface involvement manifested as keratitis. PMID: 30192690 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)

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Mucormycosis Endophthalmitis in a Silicone Oil-Filled Eye of an Immunocompetent Patient.

CONCLUSIONS: To the best of our knowledge, this is the first report of mucor endophthalmitis in a silicone oil-filled globe of an immunocompetent patient. PMID: 30192700 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)

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Pairing New Words With Unfamiliar Objects: Comparing Children With and Without Cochlear Implants.

Conclusion: This study provides preliminary evidence that children with cochlear implants approach mapping novel words to and soliciting information about unfamiliar objects differently than children with normal hearing. PMID: 30178030 [PubMed - as supplied by publisher] (Source: Journal of speech, language, and hearing research : JSLHR)

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Pure-Tone Frequency Discrimination in Preschoolers, Young School-Age Children, and Adults.

Conclusions: Thresholds for school-age children were broadly similar to those previously observed using a forced-choice procedure. Although there was a trend for improved performance with increasing age, no significant age effect was observed between preschoolers and school-age children. The practice of excluding participants based on failure to meet conditioning criteria in an observer-based task could contribute to the relatively good performance observed for preschoolers in this study and the adultlike performance previously observed in infants. PMID: 30167659 [PubMed - as supplied by publisher] (Source: Journal of speech, language, and hearing research : JSLHR)

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An Application of Network Science to Phonological Sequence Learning in Children With Developmental Language Disorder.

Conclusions: Network science provides significant insights into phonological learning trajectories in children with DLD and their typically developing peers. Importantly, errors in word production by children with DLD do not surface as a result of weakness in articulatory control. Instead, results suggest that speech errors in DLD may relate to deficits in sound sequencing. PMID: 30167667 [PubMed - as supplied by publisher] (Source: Journal of speech, language, and hearing research : JSLHR)

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A Simple Method to Obtain Basic Acoustic Measures From Video Recordings as Subtitles.

Conclusions: This method is useful in integrating the acoustic measures with any kind of video recordings containing audio data when inbuilt hardware means are not available. However, calibration and other technical aspects related to data acquisition and synchronization described in this article should be properly taken care of during the recording. PMID: 30167666 [PubMed - as supplied by publisher] (Source: Journal of speech, language, and hearing research : JSLHR)

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The Effects of Syntactic Complexity and Sentence Length on the Speech Motor Control of School-Age Children Who Stutter.

Conclusions: The speech motor systems of school-age CWS appear to be particularly vulnerable to processing demands associated with increased sentence length, as evidenced by increased LAVar. Increasing the length and complexity of the sentence stimuli also resulted in reduced production accuracy and increased stuttering frequency. We discuss these findings within a motor control framework of speech production. PMID: 30128477 [PubMed - as supplied by publisher] (Source: Journal of speech, language, and hearing research : JSLHR)

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Head and neck Cancer: Overcoming Challenges in Treatment

Source: www.curetoday.com Author: staff Itzhak Brook, M.D., M.Sc., shares the story of his initial diagnosis and treatment for cancer of the […]

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Head and neck cancer: An overview of head and neck cancer

Source: www.curetoday.com Author: staff Meryl Kaufman, M.Ed., CCC-SLP, BRS-S, and Itzhak Brook, M.D., M.Sc., board members of the Head and Neck Cancer […]

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Head and neck cancer: Novel treatment approaches

Source: www.curetoday.com Author: staff Meryl Kaufman, M.Ed., CCC-SLP, BRS-S, and Itzhak Brook, M.D., M.Sc., board members of the Head and Neck […]

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Cancer biology graduate student travels ‘ROCKy’ road toward a cure for post-radiation dry mouth

Source: medicalxpress.com Author: staff, University of Arizona The United States is in the midst of a head-and-neck cancer epidemic. Although survival […]

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E-cigarettes ‘could give you mouth cancer by damaging your DNA’

Source: metro.co.uk Author: Zoe Drewett Researchers say vaping could lead to an increased risk of developing mouth cancer. A study carried out […]

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Why a patient paid a $285 copay for a $40 drug

Source: pbs.org Author: Megan Thompson Two years ago Gretchen Liu, 78, had a transient ischemic attack — which experts sometimes call […]

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How Do Age and Hearing Loss Impact Spectral Envelope Perception?

Conclusions: The spectral envelope perception as measured by spectral modulation detection thresholds is compromised by hearing loss at higher spectral modulation frequencies, consistent with predictions of reduced spectral resolution known to accompany sensorineural hearing loss. Spectral envelope perception is not negatively impacted by advancing age at any spectral modulation frequency between 0.5 and 8.0 cycles/octave. PMID: 30178062 [PubMed - as supplied by publisher] (Source: Journal of speech, language, and hearing research : JSLHR)

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Pairing New Words With Unfamiliar Objects: Comparing Children With and Without Cochlear Implants.

Conclusion: This study provides preliminary evidence that children with cochlear implants approach mapping novel words to and soliciting information about unfamiliar objects differently than children with normal hearing. PMID: 30178030 [PubMed - as supplied by publisher] (Source: Journal of speech, language, and hearing research : JSLHR)

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Perceived Voice Quality and Voice-Related Problems Among Older Adults With Hearing Impairments.

Conclusions: The results indicate that hearing impairments and hearing aids affect several aspects of vocal satisfaction in older adults. A greater understanding of how hearing impairments and hearing aids relate to voice problems may contribute to better voice and hearing care. PMID: 30167670 [PubMed - as supplied by publisher] (Source: Journal of speech, language, and hearing research : JSLHR)

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Pure-Tone Frequency Discrimination in Preschoolers, Young School-Age Children, and Adults.

Conclusions: Thresholds for school-age children were broadly similar to those previously observed using a forced-choice procedure. Although there was a trend for improved performance with increasing age, no significant age effect was observed between preschoolers and school-age children. The practice of excluding participants based on failure to meet conditioning criteria in an observer-based task could contribute to the relatively good performance observed for preschoolers in this study and the adultlike performance previously observed in infants. PMID: 30167659 [PubMed - as supplied by publisher] (Source: Journal of speech, language, and hearing research : JSLHR)

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An Application of Network Science to Phonological Sequence Learning in Children With Developmental Language Disorder.

Conclusions: Network science provides significant insights into phonological learning trajectories in children with DLD and their typically developing peers. Importantly, errors in word production by children with DLD do not surface as a result of weakness in articulatory control. Instead, results suggest that speech errors in DLD may relate to deficits in sound sequencing. PMID: 30167667 [PubMed - as supplied by publisher] (Source: Journal of speech, language, and hearing research : JSLHR)

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The Effects of Syntactic Complexity and Sentence Length on the Speech Motor Control of School-Age Children Who Stutter.

Conclusions: The speech motor systems of school-age CWS appear to be particularly vulnerable to processing demands associated with increased sentence length, as evidenced by increased LAVar. Increasing the length and complexity of the sentence stimuli also resulted in reduced production accuracy and increased stuttering frequency. We discuss these findings within a motor control framework of speech production. PMID: 30128477 [PubMed - as supplied by publisher] (Source: Journal of speech, language, and hearing research : JSLHR)

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Erratum.

Authors: PMID: 30128559 [PubMed - as supplied by publisher] (Source: Journal of speech, language, and hearing research : JSLHR)

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Head and neck Cancer: Overcoming Challenges in Treatment

Source: www.curetoday.com Author: staff Itzhak Brook, M.D., M.Sc., shares the story of his initial diagnosis and treatment for cancer of the […]

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Head and neck cancer: An overview of head and neck cancer

Source: www.curetoday.com Author: staff Meryl Kaufman, M.Ed., CCC-SLP, BRS-S, and Itzhak Brook, M.D., M.Sc., board members of the Head and Neck Cancer […]

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Head and neck cancer: Novel treatment approaches

Source: www.curetoday.com Author: staff Meryl Kaufman, M.Ed., CCC-SLP, BRS-S, and Itzhak Brook, M.D., M.Sc., board members of the Head and Neck […]

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2MNwsqK

Head and neck cancer: Getting a diagnosis of head and neck cancer

Source: www.curetoday.com Author: staff Meryl Kaufman, M.Ed., CCC-SLP, BRS-S, and Itzhak Brook, M.D., M.Sc., board members of the Head and Neck […]

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2CjXktp

Cancer biology graduate student travels ‘ROCKy’ road toward a cure for post-radiation dry mouth

Source: medicalxpress.com Author: staff, University of Arizona The United States is in the midst of a head-and-neck cancer epidemic. Although survival […]

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How early do the effects of smoking start? Earlier than you think

Source: Author: Julia Mullaney Smoking's destructive nature has been known for quite a while. But many people think that a cigarette […]

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DCD: Oropharyngeal squamous cell carcinoma now and most common HPV associated with cancer

In 2015, oropharyngeal squamous cell carcinoma surpassed cervical cancer as the most common HPV-associated cancer in the U.S., with 15,479 cases […]

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Why a patient paid a $285 copay for a $40 drug

Source: pbs.org Author: Megan Thompson Two years ago Gretchen Liu, 78, had a transient ischemic attack — which experts sometimes call […]

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2NmwTI7

Smoking, cancer, heart disease, and the oral-systemic link: Where we are with research

Source: www.dentistryiq.com Author: Richard H. Nagelberg, DDS Dr. Richard Nagelberg examines the links between smoking, lung cancer, and heart disease, as […]

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Study: Cetuximab, radiation inferior to standard HPV throat cancer treatment

Source: upi.com Author: Allen Cone Treating HPV-positive throat cancer with cetuximab and radiation had worse overall and progression-free survival results compared […]

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Expression profiles of defense genes in cassava storage roots upon exposure to Phytopythium sp., causal agent of soft root rot disease

Publication date: Available online 8 September 2018Source: Physiological and Molecular Plant PathologyAuthor(s): Aline Medeiros Lima, Elisa Ferreira Moura, Alessandra Keiko Nakasone Ishida, Angelo Cleiton da Costa Pereira, Sávio Pinho dos Reis, Cláudia Regina Batista de SouzaAbstractCassava is one of the most important crops in Africa, Asia and Latin America, where millions of people depend on its starchy storage roots as their main source of energy. In Brazil, cassava is cultivated in all regions; however, soft root rot disease has hampered its production mainly in the Amazon region. The identification of Phytopythium sp., as the causal agent of soft root rot disease in cassava plants collected in Brazil, was recently reported. Here, our main aim was to evaluate changes in expression le...

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Recurrent alveolar hemorrhage: How do you treat that which you cannot see?

Publication date: Available online 8 September 2018Source: Respiratory Medicine Case ReportsAuthor(s): Jobin Philipose, A. Siddiqui Faraz, Jiyoung Wong, Shimshon Wiesel, Ziad Esper, E. Elsayegh DanyAbstractDiffuse alveolar hemorrhage (DAH) is a rare and life-threatening event which is characterized by bleeding into the alveolar spaces of the lung. Etiology of DAH can be broadly divided into immune and non-immune mediated disease. In the absence of infection or malignancy, an immunological workup is required to find the cause of alveolar bleed. Rarely, there is a failure to establish a definitive etiology in patients with DAH. In those scenarios, patients who do not respond to steroids, plasmapheresis should be considered as a rescue treatment to prevent catastrophic outcomes. Herein, we pr...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2wSTB14

Expression profiles of defense genes in cassava storage roots upon exposure to Phytopythium sp., causal agent of soft root rot disease

Publication date: Available online 8 September 2018Source: Physiological and Molecular Plant PathologyAuthor(s): Aline Medeiros Lima, Elisa Ferreira Moura, Alessandra Keiko Nakasone Ishida, Angelo Cleiton da Costa Pereira, Sávio Pinho dos Reis, Cláudia Regina Batista de SouzaAbstractCassava is one of the most important crops in Africa, Asia and Latin America, where millions of people depend on its starchy storage roots as their main source of energy. In Brazil, cassava is cultivated in all regions; however, soft root rot disease has hampered its production mainly in the Amazon region. The identification of Phytopythium sp., as the causal agent of soft root rot disease in cassava plants collected in Brazil, was recently reported. Here, our main aim was to evaluate changes in expression le...

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2M6qbkJ

Recurrent alveolar hemorrhage: How do you treat that which you cannot see?

Publication date: Available online 8 September 2018Source: Respiratory Medicine Case ReportsAuthor(s): Jobin Philipose, A. Siddiqui Faraz, Jiyoung Wong, Shimshon Wiesel, Ziad Esper, E. Elsayegh DanyAbstractDiffuse alveolar hemorrhage (DAH) is a rare and life-threatening event which is characterized by bleeding into the alveolar spaces of the lung. Etiology of DAH can be broadly divided into immune and non-immune mediated disease. In the absence of infection or malignancy, an immunological workup is required to find the cause of alveolar bleed. Rarely, there is a failure to establish a definitive etiology in patients with DAH. In those scenarios, patients who do not respond to steroids, plasmapheresis should be considered as a rescue treatment to prevent catastrophic outcomes. Herein, we pr...

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Relationship of age to foramen of Huschke and investigation of the development of spontaneous temporomandibular joint herniation

The aim of this study was to determine the prevalence, localization, and width of the foramen of Huschke (FH) and the relationship between age and FH. Another aim was to investigate the development of spontaneous temporomandibular joint (TMJ) herniation. This was a retrospective review of high-resolution computed tomography images of the temporal bone of 1025 patients. The prevalence of FH and the axial and sagittal diameters of the foramen were evaluated. Cases were found in which the TMJ had herniated through FH into the EAC.

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Relationship of age to foramen of Huschke and investigation of the development of spontaneous temporomandibular joint herniation

The aim of this study was to determine the prevalence, localization, and width of the foramen of Huschke (FH) and the relationship between age and FH. Another aim was to investigate the development of spontaneous temporomandibular joint (TMJ) herniation. This was a retrospective review of high-resolution computed tomography images of the temporal bone of 1025 patients. The prevalence of FH and the axial and sagittal diameters of the foramen were evaluated. Cases were found in which the TMJ had herniated through FH into the EAC.

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Management of osteoradionecrosis of the jaws with pentoxifylline–tocopherol: a systematic review of the literature and meta-analysis

Osteoradionecrosis (ORN) of the jaws remains among the most commonly encountered and challenging complications of radiotherapy to the head and neck. The purpose of this study was to provide a review of the medical management for ORN and evaluate the reported outcomes with the use of pentoxifylline and tocopherol (PENTO), by means of a systematic review and meta-analysis. The predictor variable was the use of PENTO in the treatment of ORN. The outcome variable was the proportion of full recovery or significant improvement not requiring further intervention.

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Endoscopic laryngo-pharyngeal surgery for elderly patients

Due to the rising number of elderly patients and advances in endoscopic devices, early laryngeal and pharyngeal cancers are increasingly found in elderly patients. In these cases, minimally invasive endoscopic larygo-pharyngeal surgery (ELPS) may be indicated. However, the safety and efficacy of ELPS in elderly populations has not been established. The purpose of this study was to investigate the safety, outcomes and feasibility of ELPS in very elderly patients.

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Endolymphatic hydrops severity in magnetic resonance imaging evidences disparate vestibular test results

It has been suggested that in Ménière's disease (MD) a dissociated result in the caloric test (abnormal result) and video head-impulse test (normal result) probably indicates that hydrops affects the membranous labyrinth in the horizontal semicircular canal (HSC). The hypothesis in this study is that based on endolymphatic hydrops' cochleocentric progression, hydrops should also be more severe in the vestibule of these patients than in those for whom both tests are normal.

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Endoscopic laryngo-pharyngeal surgery for elderly patients

Due to the rising number of elderly patients and advances in endoscopic devices, early laryngeal and pharyngeal cancers are increasingly found in elderly patients. In these cases, minimally invasive endoscopic larygo-pharyngeal surgery (ELPS) may be indicated. However, the safety and efficacy of ELPS in elderly populations has not been established. The purpose of this study was to investigate the safety, outcomes and feasibility of ELPS in very elderly patients.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2CAJF1k

Endolymphatic hydrops severity in magnetic resonance imaging evidences disparate vestibular test results

It has been suggested that in Ménière's disease (MD) a dissociated result in the caloric test (abnormal result) and video head-impulse test (normal result) probably indicates that hydrops affects the membranous labyrinth in the horizontal semicircular canal (HSC). The hypothesis in this study is that based on endolymphatic hydrops' cochleocentric progression, hydrops should also be more severe in the vestibule of these patients than in those for whom both tests are normal.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2CBJ2o8

Anti-IL5 treatments in severe asthma by blood eosinophil thresholds: indirect treatment comparison

In the absence of head-to-head comparisons, this indirect treatment comparison provides clinically relevant, comparative information on the efficacy of licensed formulations of the three approved anti-IL5 pathway therapies in SEA by baseline blood eosinophil count.

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Differential expression of functional chemokine receptors on human blood and lung group 2 innate lymphoid cells (ILC2s)

Differential expression of chemokine receptors on lymphocytes enables tissue and disease specific recruitment and activation of various lymphocytes. We have shown that human ILC2s display a different subset of functional chemokine receptors when isolated from blood or lung tissue.

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Tobacco smoke as a risk factor for allergic sensitization in adults: conclusions of a systematic review and meta-analysis



from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2NW6n53

STAT5B deficiency due to a novel missense mutation in the coiled-coil domain

A novel homozygous missense mutation in the coiled-coil domain of STAT5B causes an immunodeficiency syndrome characterised by short stature due to GH insensitivity, immune dysregulation and hypothyroidism but currently without pulmonary disease or T-cell lymphopenia.

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Lower Perinatal Exposure to Proteobacteria is an Independent Predictor of Early Childhood Wheezing

Circulating free Proteobacterial DNA in umbilical cord serum is associated with features of childhood asthma including maternal atopy, early childhood wheezing, and bronchodilator response.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2O1zJ22

Anti-IL5 treatments in severe asthma by blood eosinophil thresholds: indirect treatment comparison

In the absence of head-to-head comparisons, this indirect treatment comparison provides clinically relevant, comparative information on the efficacy of licensed formulations of the three approved anti-IL5 pathway therapies in SEA by baseline blood eosinophil count.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2M8ogfu

Differential expression of functional chemokine receptors on human blood and lung group 2 innate lymphoid cells (ILC2s)

Differential expression of chemokine receptors on lymphocytes enables tissue and disease specific recruitment and activation of various lymphocytes. We have shown that human ILC2s display a different subset of functional chemokine receptors when isolated from blood or lung tissue.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2wUiRUn

Tobacco smoke as a risk factor for allergic sensitization in adults: conclusions of a systematic review and meta-analysis



from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2NW6n53

STAT5B deficiency due to a novel missense mutation in the coiled-coil domain

A novel homozygous missense mutation in the coiled-coil domain of STAT5B causes an immunodeficiency syndrome characterised by short stature due to GH insensitivity, immune dysregulation and hypothyroidism but currently without pulmonary disease or T-cell lymphopenia.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2wWfmwF

Lower Perinatal Exposure to Proteobacteria is an Independent Predictor of Early Childhood Wheezing

Circulating free Proteobacterial DNA in umbilical cord serum is associated with features of childhood asthma including maternal atopy, early childhood wheezing, and bronchodilator response.

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Unmet Need and Financial Impact Disparities for US Children with ADHD

ConclusionDeeper understanding of household language's influence is important in ADHD needs assessments. Considering overall family financial circumstances may also be pertinent, particularly as children age, because earlier diagnosis was associated with adverse financial outcomes. These findings could shape future clinic policies for targeting community resources. (Source: Academic Pediatrics)

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Perceptual Encoding in Auditory Brainstem Responses: Effects of Stimulus Frequency.

Conclusions: Results demonstrate that the ABR provides a useful measure of early perceptual encoding for stimuli varying in frequency and that the tonotopic organization of the auditory system is preserved at this stage of processing for stimuli from 500 to 8000 Hz. Such a measure may serve as a useful clinical tool for evaluating a listener's ability to encode specific frequencies in sounds. Supplemental Material: https://ift.tt/2Qeaviq. PMID: 30193361 [PubMed - as supplied by publisher] (Source: Journal of speech, language, and hearing research : JSLHR)

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Erratum.

Authors: PMID: 30193369 [PubMed - as supplied by publisher] (Source: Journal of speech, language, and hearing research : JSLHR)

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Exploring the Effects of Imitating Hand Gestures and Head Nods on L1 and L2 Mandarin Tone Production.

Conclusion: Results suggest that metaphoric bodily actions do not influence the lowest levels of L1 speech production in a tonal language and may play a very modest role during preliminary L2 learning. PMID: 30193334 [PubMed - as supplied by publisher] (Source: Journal of speech, language, and hearing research : JSLHR)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2QdM0C9

Unmet Need and Financial Impact Disparities for US Children with ADHD

ConclusionDeeper understanding of household language's influence is important in ADHD needs assessments. Considering overall family financial circumstances may also be pertinent, particularly as children age, because earlier diagnosis was associated with adverse financial outcomes. These findings could shape future clinic policies for targeting community resources. (Source: Academic Pediatrics)

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2QaYomi

Perceptual Encoding in Auditory Brainstem Responses: Effects of Stimulus Frequency.

Conclusions: Results demonstrate that the ABR provides a useful measure of early perceptual encoding for stimuli varying in frequency and that the tonotopic organization of the auditory system is preserved at this stage of processing for stimuli from 500 to 8000 Hz. Such a measure may serve as a useful clinical tool for evaluating a listener's ability to encode specific frequencies in sounds. Supplemental Material: https://ift.tt/2Qeaviq. PMID: 30193361 [PubMed - as supplied by publisher] (Source: Journal of speech, language, and hearing research : JSLHR)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2O19Gbm

Erratum.

Authors: PMID: 30193369 [PubMed - as supplied by publisher] (Source: Journal of speech, language, and hearing research : JSLHR)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2MbPNg8

Exploring the Effects of Imitating Hand Gestures and Head Nods on L1 and L2 Mandarin Tone Production.

Conclusion: Results suggest that metaphoric bodily actions do not influence the lowest levels of L1 speech production in a tonal language and may play a very modest role during preliminary L2 learning. PMID: 30193334 [PubMed - as supplied by publisher] (Source: Journal of speech, language, and hearing research : JSLHR)

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The use of intra-articular analgesics to improve outcomes after temporomandibular joint arthrocentesis: a review

Abstract

Purpose

The aim of this review was to assess the efficacy of intra-articular analgesics in improving outcomes after temporomandibular joint (TMJ) arthrocentesis.

Material and methods

An electronic search of PubMed, Scopus, and Google scholar databases was performed for papers in English published up to December 2017 reporting the use of intra-articular analgesics after TMJ arthrocentesis. Randomized controlled trials (RCTs), controlled clinical trials (CCTs), comparative studies, retrospective studies, and case series were included while case reports, technical reports, animal studies, cadaveric studies, and review papers were excluded.

Results

Of the six studies included in the review, three were RCTs, two were randomized comparative studies, and one was a retrospective study. Both opioids and non-steroidal anti-inflammatory drugs have been used after TMJ arthrocentesis. Morphine, tramadol, fentanyl, buprenorphine, tenoxicam, and COX-2 inhibitors are the drugs used till date. Placebo-controlled studies reported improved outcomes after TMJ arthrocentesis with morphine and fentanyl but no such results with buprenorphine and tenoxicam. Tramadol was found to be better than COX-2 inhibitor. The quality of literature was not high.

Conclusions

There is inconclusive evidence in literature on the benefits of using intra-articular analgesics after TMJ arthrocentesis. Well-designed high-quality RCTs with standard protocol studying the effects of intra-articular opioids and NSAIDS after TMJ arthrocentesis would provide stronger evidence on its use.



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The use of intra-articular analgesics to improve outcomes after temporomandibular joint arthrocentesis: a review

Abstract

Purpose

The aim of this review was to assess the efficacy of intra-articular analgesics in improving outcomes after temporomandibular joint (TMJ) arthrocentesis.

Material and methods

An electronic search of PubMed, Scopus, and Google scholar databases was performed for papers in English published up to December 2017 reporting the use of intra-articular analgesics after TMJ arthrocentesis. Randomized controlled trials (RCTs), controlled clinical trials (CCTs), comparative studies, retrospective studies, and case series were included while case reports, technical reports, animal studies, cadaveric studies, and review papers were excluded.

Results

Of the six studies included in the review, three were RCTs, two were randomized comparative studies, and one was a retrospective study. Both opioids and non-steroidal anti-inflammatory drugs have been used after TMJ arthrocentesis. Morphine, tramadol, fentanyl, buprenorphine, tenoxicam, and COX-2 inhibitors are the drugs used till date. Placebo-controlled studies reported improved outcomes after TMJ arthrocentesis with morphine and fentanyl but no such results with buprenorphine and tenoxicam. Tramadol was found to be better than COX-2 inhibitor. The quality of literature was not high.

Conclusions

There is inconclusive evidence in literature on the benefits of using intra-articular analgesics after TMJ arthrocentesis. Well-designed high-quality RCTs with standard protocol studying the effects of intra-articular opioids and NSAIDS after TMJ arthrocentesis would provide stronger evidence on its use.



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Immune checkpoint inhibitors as a bridge to allogeneic transplantation with posttransplant cyclophosphamide.

Authors: Schoch LK, Cooke KR, Wagner-Johnston ND, Gojo I, Swinnen LJ, Imus P, Fuchs EJ, Levis M, Ambinder RF, Jones RJ, Gladstone DE Abstract Published reports suggest that immune checkpoint inhibitors (ICIs) before allogeneic blood or marrow transplantation (alloBMT) may increase the incidence of graft-versus-host disease (GvHD), immune-related adverse events, and nonrelapse mortality (NRM); this led to the US Food and Drug Administration issuing a "Warning and Precaution" regarding the potential for life-threatening immune-mediated complications associated with alloBMT after nivolumab and pembrolizumab. We retrospectively reviewed the outcomes of 14 consecutive patients who received ICIs as their final salvage therapy before T-cell-replete alloBMT using reduced-intensity conditio...

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Immunological characteristics of Mycobacterium tuberculosis subunit vaccines immunized through different routes

Publication date: Available online 6 September 2018Source: Microbial PathogenesisAuthor(s): Yanzhi Lu, Jian Kang, Huanhuan Ning, Lifei Wang, Yanhui Xu, Ying Xue, Zhikai Xu, Xingan Wu, Yinlan BaiAbstractTuberculosis is chronic infectious disease caused by Mycobacterium tuberculosis (M.tb) that is prevalent worldwide. Several specific antigens, such as Antigen 85B (Ag85B) and 6 kDa early secretory antigenic target (ESAT-6) protein of M.tb, are listed as some of the candidate subunit vaccines against M.tb. ESAT-6, as a virulent factor and differential gene in M.tb, shows insufficient immunogenicity in animal model. In order to investigate the ways to improve the immunogenicity of ESAT-6, we immunized ESAT-6 by subcutaneous and intramuscular routes with different adjuvants. We found that ESA...

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Inflammation, immunity and allergy

Publication date: Available online 7 September 2018Source: Anaesthesia & Intensive Care MedicineAuthor(s): Darryl Stewart, Alistair NicholAbstractInjury or foreign invasion will instigate a cascade of events directed at eliminating the intruder and augmenting the healing process. This involves the unification of two separate processes (inflammatory and immune processes) to provide an effective host defence. Chemical mediators converge on the site of tissue damage and exert local and distant effects. The immune response is divided into innate and acquired immunity. The immediate, non-specific innate response, combined with the specifically targeted acquired response, provide our major defence mechanisms. Lymphocytes and immunoglobulins are the hallmark of acquired immunity. Regulation of th...

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Immune checkpoint inhibitors as a bridge to allogeneic transplantation with posttransplant cyclophosphamide.

Authors: Schoch LK, Cooke KR, Wagner-Johnston ND, Gojo I, Swinnen LJ, Imus P, Fuchs EJ, Levis M, Ambinder RF, Jones RJ, Gladstone DE Abstract Published reports suggest that immune checkpoint inhibitors (ICIs) before allogeneic blood or marrow transplantation (alloBMT) may increase the incidence of graft-versus-host disease (GvHD), immune-related adverse events, and nonrelapse mortality (NRM); this led to the US Food and Drug Administration issuing a "Warning and Precaution" regarding the potential for life-threatening immune-mediated complications associated with alloBMT after nivolumab and pembrolizumab. We retrospectively reviewed the outcomes of 14 consecutive patients who received ICIs as their final salvage therapy before T-cell-replete alloBMT using reduced-intensity conditio...

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Immunological characteristics of Mycobacterium tuberculosis subunit vaccines immunized through different routes

Publication date: Available online 6 September 2018Source: Microbial PathogenesisAuthor(s): Yanzhi Lu, Jian Kang, Huanhuan Ning, Lifei Wang, Yanhui Xu, Ying Xue, Zhikai Xu, Xingan Wu, Yinlan BaiAbstractTuberculosis is chronic infectious disease caused by Mycobacterium tuberculosis (M.tb) that is prevalent worldwide. Several specific antigens, such as Antigen 85B (Ag85B) and 6 kDa early secretory antigenic target (ESAT-6) protein of M.tb, are listed as some of the candidate subunit vaccines against M.tb. ESAT-6, as a virulent factor and differential gene in M.tb, shows insufficient immunogenicity in animal model. In order to investigate the ways to improve the immunogenicity of ESAT-6, we immunized ESAT-6 by subcutaneous and intramuscular routes with different adjuvants. We found that ESA...

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Inflammation, immunity and allergy

Publication date: Available online 7 September 2018Source: Anaesthesia & Intensive Care MedicineAuthor(s): Darryl Stewart, Alistair NicholAbstractInjury or foreign invasion will instigate a cascade of events directed at eliminating the intruder and augmenting the healing process. This involves the unification of two separate processes (inflammatory and immune processes) to provide an effective host defence. Chemical mediators converge on the site of tissue damage and exert local and distant effects. The immune response is divided into innate and acquired immunity. The immediate, non-specific innate response, combined with the specifically targeted acquired response, provide our major defence mechanisms. Lymphocytes and immunoglobulins are the hallmark of acquired immunity. Regulation of th...

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Single-Channel Multi-talker Speech Recognition with Permutation Invariant Training

Publication date: Available online 7 September 2018Source: Speech CommunicationAuthor(s): Yanmin Qian, Xuankai Chang, Dong YuAbstractAlthough great progress has been made in automatic speech recognition (ASR), significant performance degradation is still observed when recognizing multi-talker mixed speech. In this paper, we propose and evaluate several architectures to address this problem under the assumption that only a single channel of mixed signal is available. Our technique extends permutation invariant training (PIT) by introducing the front-end feature separation module with the minimum mean square error (MSE) criterion and the back-end recognition module with the minimum cross entropy (CE) criterion. More specifically, during training we compute the average MSE or CE over the whol...

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Editorial Board

Publication date: October 2018Source: Journal of Photochemistry and Photobiology B: Biology, Volume 187Author(s): (Source: Journal of Photochemistry and Photobiology B: Biology)

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Stuttering-like hesitation in speech during acute/post-acute phase of immune-mediated encephalitis

ConclusionThis case reports a probable immune-mediated encephalitis that resulted in acquired stuttering. The effect of "slowed" oscillatory brain activity on motor skills requesting sequencing and fine coordination (e.g. speech) could result in less "synchronized" systems, easily prone to disruptions. (Source: Journal of Fluency Disorders)

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Can listeners hear the difference between children with normal hearing and children with a hearing impairment?

This study focuses on the perception of HI speech in comparison to NH children's speech. The purpose of this study was to investigate whether adult listeners can identify the speech of NH and HI children. Moreover, it is studied whether listeners' experience and the children's length of device use play a role in that assessment. For this study, short utterances of 7 children with a cochlear implant (CI), 7 children with an acoustic hearing aid (HA) and 7 children with NH were presented to 90 listeners who were required to specify the hearing status of each speech sample. The judges had different degrees of familiarity with hearing disorders: there were 30 audiologists, 30 primary schoolteachers and 30 inexperienced listeners. The results show that the speech of children with NH and HI can ...

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Single-Channel Multi-talker Speech Recognition with Permutation Invariant Training

Publication date: Available online 7 September 2018Source: Speech CommunicationAuthor(s): Yanmin Qian, Xuankai Chang, Dong YuAbstractAlthough great progress has been made in automatic speech recognition (ASR), significant performance degradation is still observed when recognizing multi-talker mixed speech. In this paper, we propose and evaluate several architectures to address this problem under the assumption that only a single channel of mixed signal is available. Our technique extends permutation invariant training (PIT) by introducing the front-end feature separation module with the minimum mean square error (MSE) criterion and the back-end recognition module with the minimum cross entropy (CE) criterion. More specifically, during training we compute the average MSE or CE over the whol...

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Editorial Board

Publication date: October 2018Source: Journal of Photochemistry and Photobiology B: Biology, Volume 187Author(s): (Source: Journal of Photochemistry and Photobiology B: Biology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2oQVkPP

Stuttering-like hesitation in speech during acute/post-acute phase of immune-mediated encephalitis

ConclusionThis case reports a probable immune-mediated encephalitis that resulted in acquired stuttering. The effect of "slowed" oscillatory brain activity on motor skills requesting sequencing and fine coordination (e.g. speech) could result in less "synchronized" systems, easily prone to disruptions. (Source: Journal of Fluency Disorders)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2wV4yOO

Can listeners hear the difference between children with normal hearing and children with a hearing impairment?

This study focuses on the perception of HI speech in comparison to NH children's speech. The purpose of this study was to investigate whether adult listeners can identify the speech of NH and HI children. Moreover, it is studied whether listeners' experience and the children's length of device use play a role in that assessment. For this study, short utterances of 7 children with a cochlear implant (CI), 7 children with an acoustic hearing aid (HA) and 7 children with NH were presented to 90 listeners who were required to specify the hearing status of each speech sample. The judges had different degrees of familiarity with hearing disorders: there were 30 audiologists, 30 primary schoolteachers and 30 inexperienced listeners. The results show that the speech of children with NH and HI can ...

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The use of intra-articular analgesics to improve outcomes after temporomandibular joint arthrocentesis: a review

Abstract

Purpose

The aim of this review was to assess the efficacy of intra-articular analgesics in improving outcomes after temporomandibular joint (TMJ) arthrocentesis.

Material and methods

An electronic search of PubMed, Scopus, and Google scholar databases was performed for papers in English published up to December 2017 reporting the use of intra-articular analgesics after TMJ arthrocentesis. Randomized controlled trials (RCTs), controlled clinical trials (CCTs), comparative studies, retrospective studies, and case series were included while case reports, technical reports, animal studies, cadaveric studies, and review papers were excluded.

Results

Of the six studies included in the review, three were RCTs, two were randomized comparative studies, and one was a retrospective study. Both opioids and non-steroidal anti-inflammatory drugs have been used after TMJ arthrocentesis. Morphine, tramadol, fentanyl, buprenorphine, tenoxicam, and COX-2 inhibitors are the drugs used till date. Placebo-controlled studies reported improved outcomes after TMJ arthrocentesis with morphine and fentanyl but no such results with buprenorphine and tenoxicam. Tramadol was found to be better than COX-2 inhibitor. The quality of literature was not high.

Conclusions

There is inconclusive evidence in literature on the benefits of using intra-articular analgesics after TMJ arthrocentesis. Well-designed high-quality RCTs with standard protocol studying the effects of intra-articular opioids and NSAIDS after TMJ arthrocentesis would provide stronger evidence on its use.



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The use of intra-articular analgesics to improve outcomes after temporomandibular joint arthrocentesis: a review

Abstract

Purpose

The aim of this review was to assess the efficacy of intra-articular analgesics in improving outcomes after temporomandibular joint (TMJ) arthrocentesis.

Material and methods

An electronic search of PubMed, Scopus, and Google scholar databases was performed for papers in English published up to December 2017 reporting the use of intra-articular analgesics after TMJ arthrocentesis. Randomized controlled trials (RCTs), controlled clinical trials (CCTs), comparative studies, retrospective studies, and case series were included while case reports, technical reports, animal studies, cadaveric studies, and review papers were excluded.

Results

Of the six studies included in the review, three were RCTs, two were randomized comparative studies, and one was a retrospective study. Both opioids and non-steroidal anti-inflammatory drugs have been used after TMJ arthrocentesis. Morphine, tramadol, fentanyl, buprenorphine, tenoxicam, and COX-2 inhibitors are the drugs used till date. Placebo-controlled studies reported improved outcomes after TMJ arthrocentesis with morphine and fentanyl but no such results with buprenorphine and tenoxicam. Tramadol was found to be better than COX-2 inhibitor. The quality of literature was not high.

Conclusions

There is inconclusive evidence in literature on the benefits of using intra-articular analgesics after TMJ arthrocentesis. Well-designed high-quality RCTs with standard protocol studying the effects of intra-articular opioids and NSAIDS after TMJ arthrocentesis would provide stronger evidence on its use.



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Documenting current practices in the management of deaf suspects in the USA

This study combines previous research on deaf suspects, which has been published largely through the framework of deaf studies, with the insight of practitioners to identify a list of current practices used by US law enforcement when handling deaf suspects. (Source: Policing: An International Journal of Police Strategies and Management)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2NqlI0V

Can listeners hear the difference between children with normal hearing and children with a hearing impairment?

This study focuses on the perception of HI speech in comparison to NH children's speech. The purpose of this study was to investigate whether adult listeners can identify the speech of NH and HI children. Moreover, it is studied whether listeners' experience and the children's length of device use play a role in that assessment. For this study, short utterances of 7 children with a cochlear implant (CI), 7 children with an acoustic hearing aid (HA) and 7 children with NH were presented to 90 listeners who were required to specify the hearing status of each speech sample. The judges had different degrees of familiarity with hearing disorders: there were 30 audiologists, 30 primary schoolteachers and 30 inexperienced listeners. The results show that the speech of children with NH and HI can ...

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Mycoplasma-Induced Toxic Epidermal Necrolysis with Severe Mucositis

Publication date: Available online 7 September 2018Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Ze-Hu Liu, Hong Shen (Source: The Journal of Allergy and Clinical Immunology: In Practice)

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Manipulation of Non-canonical NF- κB Signaling by Non-oncogenic Viruses

AbstractNuclear factor (NF)- κB is a major regulator of antiviral response. Viral pathogens exploit NF-κB activation pathways to avoid cellular mechanisms that eliminate the infection. Canonical (classical) NF-κB signaling, which regulates innate immune response, cell survival and inflammation, is often manipulated by viral pathogens that can counteract antiviral response. Oncogenic viruses can modulate not only canonical, but also non-canonical (alternative) NF-κB activation pathways. The non-canonical NF-κB signaling is responsible for adaptive immunity and plays a role in lymphoid organogenesis, B cell development , as well as bone metabolism. Thus, non-canonical NF-κB activation has been linked to lymphoid malignancies. However, some data strongly suggest that the non-canonical N...

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Improving efficacy of cancer immunotherapy through targeting of macrophages

. (Source: Human Vaccines and Immunotherapeutics)

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Gallic acid attenuates allergic airway inflammation via suppressed interleukin ‐33 and group 2 innate lymphoid cells in ovalbumin‐induced asthma in mice

International Forum of Allergy&Rhinology, EarlyView. (Source: International Forum of Allergy and Rhinology)

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The immunomodulatory role of probiotics in allergy therapy

Journal of Cellular Physiology, EarlyView. (Source: Journal of Cellular Physiology)

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2NqEvt0

Documenting current practices in the management of deaf suspects in the USA

This study combines previous research on deaf suspects, which has been published largely through the framework of deaf studies, with the insight of practitioners to identify a list of current practices used by US law enforcement when handling deaf suspects. (Source: Policing: An International Journal of Police Strategies and Management)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2NqlI0V

Can listeners hear the difference between children with normal hearing and children with a hearing impairment?

This study focuses on the perception of HI speech in comparison to NH children's speech. The purpose of this study was to investigate whether adult listeners can identify the speech of NH and HI children. Moreover, it is studied whether listeners' experience and the children's length of device use play a role in that assessment. For this study, short utterances of 7 children with a cochlear implant (CI), 7 children with an acoustic hearing aid (HA) and 7 children with NH were presented to 90 listeners who were required to specify the hearing status of each speech sample. The judges had different degrees of familiarity with hearing disorders: there were 30 audiologists, 30 primary schoolteachers and 30 inexperienced listeners. The results show that the speech of children with NH and HI can ...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2CB576u

Mycoplasma-Induced Toxic Epidermal Necrolysis with Severe Mucositis

Publication date: Available online 7 September 2018Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Ze-Hu Liu, Hong Shen (Source: The Journal of Allergy and Clinical Immunology: In Practice)

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2NstWp7

Manipulation of Non-canonical NF- κB Signaling by Non-oncogenic Viruses

AbstractNuclear factor (NF)- κB is a major regulator of antiviral response. Viral pathogens exploit NF-κB activation pathways to avoid cellular mechanisms that eliminate the infection. Canonical (classical) NF-κB signaling, which regulates innate immune response, cell survival and inflammation, is often manipulated by viral pathogens that can counteract antiviral response. Oncogenic viruses can modulate not only canonical, but also non-canonical (alternative) NF-κB activation pathways. The non-canonical NF-κB signaling is responsible for adaptive immunity and plays a role in lymphoid organogenesis, B cell development , as well as bone metabolism. Thus, non-canonical NF-κB activation has been linked to lymphoid malignancies. However, some data strongly suggest that the non-canonical N...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2CwenIM

Improving efficacy of cancer immunotherapy through targeting of macrophages

. (Source: Human Vaccines and Immunotherapeutics)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Nstozz

Gallic acid attenuates allergic airway inflammation via suppressed interleukin ‐33 and group 2 innate lymphoid cells in ovalbumin‐induced asthma in mice

International Forum of Allergy&Rhinology, EarlyView. (Source: International Forum of Allergy and Rhinology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Cwel3C

The immunomodulatory role of probiotics in allergy therapy

Journal of Cellular Physiology, EarlyView. (Source: Journal of Cellular Physiology)

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Study: HPV cancer survivors at risk for second HPV cancer

Source: www.bcm.edu Author: Dipali Pathak A retrospective study led by researchers at Baylor College of Medicine and The University of Texas […]

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Natural remedies for eye allergies

(Natural News) In the U.S., more than 50 million people suffer from allergies, according to the American Academy of Allergy, Asthma and Immunology (AAAAI). Fortunately, allergies can be treated without the use of drug medications. Here are natural remedies available for allergies, particularly eye allergy: (h/t: Homeo-Pathic.esy.es) Prepare either a warm or cold compress: A... (Source: NaturalNews.com)

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Study: HPV cancer survivors at risk for second HPV cancer

Source: www.bcm.edu Author: Dipali Pathak A retrospective study led by researchers at Baylor College of Medicine and The University of Texas […]

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2NqP1jR

Natural remedies for eye allergies

(Natural News) In the U.S., more than 50 million people suffer from allergies, according to the American Academy of Allergy, Asthma and Immunology (AAAAI). Fortunately, allergies can be treated without the use of drug medications. Here are natural remedies available for allergies, particularly eye allergy: (h/t: Homeo-Pathic.esy.es) Prepare either a warm or cold compress: A... (Source: NaturalNews.com)

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Study: HPV cancer survivors at risk for second HPV cancer

Source: www.bcm.edu Author: Dipali Pathak A retrospective study led by researchers at Baylor College of Medicine and The University of Texas […]

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2NqP1jR

Study: HPV cancer survivors at risk for second HPV cancer

Source: www.bcm.edu Author: Dipali Pathak A retrospective study led by researchers at Baylor College of Medicine and The University of Texas […]

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2NqP1jR

Natural remedies for eye allergies

(Natural News) In the U.S., more than 50 million people suffer from allergies, according to the American Academy of Allergy, Asthma and Immunology (AAAAI). Fortunately, allergies can be treated without the use of drug medications. Here are natural remedies available for allergies, particularly eye allergy: (h/t: Homeo-Pathic.esy.es) Prepare either a warm or cold compress: A... (Source: NaturalNews.com)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2CuR3v4

Natural remedies for eye allergies

(Natural News) In the U.S., more than 50 million people suffer from allergies, according to the American Academy of Allergy, Asthma and Immunology (AAAAI). Fortunately, allergies can be treated without the use of drug medications. Here are natural remedies available for allergies, particularly eye allergy: (h/t: Homeo-Pathic.esy.es) Prepare either a warm or cold compress: A... (Source: NaturalNews.com)

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Proper Cut-off Levels of Serum Specific IgE to Cefaclor for Patients with Cefaclor Allergy.

CONCLUSION: Patients with cefaclor anaphylaxis exhibit high serum IgE levels. A cut-off value of 0.11 kU/L of sIgE to cefaclor is proper for identifying patients with cefaclor allergy, and 0.44 kU/L may be useful to detect anaphylaxis. PMID: 30187704 [PubMed - in process] (Source: Yonsei Medical Journal)

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Cervical lymphadenopathy: can the histogram analysis of apparent diffusion coefficient help to differentiate between lymphoma and squamous cell carcinoma in patients with unknown clinical primary tumor?

Abstract

Purpose

To retrospectively evaluate the value of whole-lesion histogram analysis of apparent diffusion coefficient (ADC) maps in differentiating between lymphoma and metastatic squamous cell carcinoma (SCC) of unknown clinical primary in neck nodes.

Methods

A total of 39 patients, 20 affected by lymphoma and 19 affected by metastatic non-nasopharyngeal SCC, were included in this retrospective study. All patients underwent MR imaging with a 1.5 T scanner system, including diffusion-weighted imaging (DWI) with three different b values (b = 0, 500 and 800 s/mm2). The entire tumor volume was manually delineated on the ADC maps, using the T2-weighted images and DWIs with b = 800 s/mm2 as a guide to the lesion location. The Mann–Whitney rank-sum test for independent samples was performed to compare the histogram parameters of patients with lymphoma and SCC.

Results

The SCCs showed significantly higher median ADC (ADCmedian) and mean ADC (ADCmean) values, compared to lymphomas (p < 0.001), while they exhibited lower kurtosis and skewness without reaching significance (p = 0.066 and 0.148, respectively). The ADCmean and ADCmedian had the best discriminative powers for differentiating lymphoma and SCC, with an area under the curve of 87% and 85%, respectively. The optimal cutoff values for ADCmean and ADCmedian as predictors for lymphoma were ≤ 0.83 × 10−3 mm2/s and ≤ 0.73 × 10−3 mm2/s, respectively.

Conclusions

The whole-lesion ADC histogram analysis of cervical lymphadenopathy may help to discriminate lymphomas from non-nasopharyngeal SCC in patients with unknown clinical primary tumor.



from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2CwUCBa

Proper Cut-off Levels of Serum Specific IgE to Cefaclor for Patients with Cefaclor Allergy.

CONCLUSION: Patients with cefaclor anaphylaxis exhibit high serum IgE levels. A cut-off value of 0.11 kU/L of sIgE to cefaclor is proper for identifying patients with cefaclor allergy, and 0.44 kU/L may be useful to detect anaphylaxis. PMID: 30187704 [PubMed - in process] (Source: Yonsei Medical Journal)

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Nvyknm

Cervical lymphadenopathy: can the histogram analysis of apparent diffusion coefficient help to differentiate between lymphoma and squamous cell carcinoma in patients with unknown clinical primary tumor?

Abstract

Purpose

To retrospectively evaluate the value of whole-lesion histogram analysis of apparent diffusion coefficient (ADC) maps in differentiating between lymphoma and metastatic squamous cell carcinoma (SCC) of unknown clinical primary in neck nodes.

Methods

A total of 39 patients, 20 affected by lymphoma and 19 affected by metastatic non-nasopharyngeal SCC, were included in this retrospective study. All patients underwent MR imaging with a 1.5 T scanner system, including diffusion-weighted imaging (DWI) with three different b values (b = 0, 500 and 800 s/mm2). The entire tumor volume was manually delineated on the ADC maps, using the T2-weighted images and DWIs with b = 800 s/mm2 as a guide to the lesion location. The Mann–Whitney rank-sum test for independent samples was performed to compare the histogram parameters of patients with lymphoma and SCC.

Results

The SCCs showed significantly higher median ADC (ADCmedian) and mean ADC (ADCmean) values, compared to lymphomas (p < 0.001), while they exhibited lower kurtosis and skewness without reaching significance (p = 0.066 and 0.148, respectively). The ADCmean and ADCmedian had the best discriminative powers for differentiating lymphoma and SCC, with an area under the curve of 87% and 85%, respectively. The optimal cutoff values for ADCmean and ADCmedian as predictors for lymphoma were ≤ 0.83 × 10−3 mm2/s and ≤ 0.73 × 10−3 mm2/s, respectively.

Conclusions

The whole-lesion ADC histogram analysis of cervical lymphadenopathy may help to discriminate lymphomas from non-nasopharyngeal SCC in patients with unknown clinical primary tumor.



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Use of 5% monoethanolamine oleate foam in oral varicose

Publication date: Available online 7 September 2018

Source: Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology

Author(s): Camila de Nazaré Alves de Oliveira Kato, Márcio Bruno Figueiredo do Amaral, Wagner Henriques de Castro, Ricardo Santiago Gomez, Ricardo Alves Mesquita

Abstract
Objective

Oral varicose is an acquired change that occurs in the veins. Usually, small oral varicose require no treatment. Aesthetic site, trauma and bleeding risk of the lesion need of intervention. This technical note describes the treatment of oral varicose by sclerotherapy in form of foam.

Method

The 5% monoethanolamine oleate was used. The foam was produced with Tessari method, in which the proportion air:liquid sclerosing was 4:1. A single application of the 0.5 mL of foam was made under local anesthesia.

Result

Signs and symptoms were minimal after the treatment. Clinical remission of the lesion was observed in two weeks.

Conclusion

The 5% monoethanolamine oleate foam showed to be effective and safety for treatment this case of the oral varicose.



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Use of 5% monoethanolamine oleate foam in oral varicose

Publication date: Available online 7 September 2018

Source: Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology

Author(s): Camila de Nazaré Alves de Oliveira Kato, Márcio Bruno Figueiredo do Amaral, Wagner Henriques de Castro, Ricardo Santiago Gomez, Ricardo Alves Mesquita

Abstract
Objective

Oral varicose is an acquired change that occurs in the veins. Usually, small oral varicose require no treatment. Aesthetic site, trauma and bleeding risk of the lesion need of intervention. This technical note describes the treatment of oral varicose by sclerotherapy in form of foam.

Method

The 5% monoethanolamine oleate was used. The foam was produced with Tessari method, in which the proportion air:liquid sclerosing was 4:1. A single application of the 0.5 mL of foam was made under local anesthesia.

Result

Signs and symptoms were minimal after the treatment. Clinical remission of the lesion was observed in two weeks.

Conclusion

The 5% monoethanolamine oleate foam showed to be effective and safety for treatment this case of the oral varicose.



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Salivary Proteome patterns of individuals exposed to High Altitude

Publication date: Available online 7 September 2018

Source: Archives of Oral Biology

Author(s): Shikha Jain, Yasmin Ahmad, Kalpana Bhargava

Abstract
Objective

Identification of molecular signatures having key roles in hypobaric hypoxia by analysing the salivary proteome. Saliva holds a promising future in the search for new clinical biomarkers that are easily accessible, less complex, accurate, and cost effective as well as being non-invasive.

Methodology

We employed qualitative proteomics approach to develop discriminatory biomarker signatures from human saliva exposed to hypobaric hypoxia. Salivary proteins were analyzed and compared between age-matched healthy subjects exposed to high altitude (~13700 ft) for seven days (HAD7) with control subjects at sea level (Normoxia) by using 2-Dimensional gel electrophoresis/Mass Spectrometry approach.

Results

Several proteins with significant differential expression were found. The up-regulated proteins were apoptosis inducing factor-2, cystatin S, cystatin SN and carbonic anhydrase 6. The down regulated proteins were polymeric immunoglobulin receptor, alpha-enolase and prolactin-inducible protein. Further confirmation of the altered proteins such as alpha enolase, carbonic anhydrase 6, prolactin-inducible protein, apoptosis inducing factor 2, cystatin S and cystatin SN was performed using immunoblotting. The expression patterns of the selected proteins observed by immunoblot were in concurrence with 2-Dimesional gel electrophoresis results, therefore affirming the authenticity of the proteomic investigation.

Conclusion

This study provides the proof of concept of salivary biomarkers for the non-invasive detection of hypobaric hypoxia induced effects. It is highly feasible to turn these biomarkers into an applicable clinical test after large scale validation.



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Salivary Proteome patterns of individuals exposed to High Altitude

Publication date: Available online 7 September 2018

Source: Archives of Oral Biology

Author(s): Shikha Jain, Yasmin Ahmad, Kalpana Bhargava

Abstract
Objective

Identification of molecular signatures having key roles in hypobaric hypoxia by analysing the salivary proteome. Saliva holds a promising future in the search for new clinical biomarkers that are easily accessible, less complex, accurate, and cost effective as well as being non-invasive.

Methodology

We employed qualitative proteomics approach to develop discriminatory biomarker signatures from human saliva exposed to hypobaric hypoxia. Salivary proteins were analyzed and compared between age-matched healthy subjects exposed to high altitude (~13700 ft) for seven days (HAD7) with control subjects at sea level (Normoxia) by using 2-Dimensional gel electrophoresis/Mass Spectrometry approach.

Results

Several proteins with significant differential expression were found. The up-regulated proteins were apoptosis inducing factor-2, cystatin S, cystatin SN and carbonic anhydrase 6. The down regulated proteins were polymeric immunoglobulin receptor, alpha-enolase and prolactin-inducible protein. Further confirmation of the altered proteins such as alpha enolase, carbonic anhydrase 6, prolactin-inducible protein, apoptosis inducing factor 2, cystatin S and cystatin SN was performed using immunoblotting. The expression patterns of the selected proteins observed by immunoblot were in concurrence with 2-Dimesional gel electrophoresis results, therefore affirming the authenticity of the proteomic investigation.

Conclusion

This study provides the proof of concept of salivary biomarkers for the non-invasive detection of hypobaric hypoxia induced effects. It is highly feasible to turn these biomarkers into an applicable clinical test after large scale validation.



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