Core-shell polymeric nanoparticles comprising BODIPY and fluorescein as ultra-bright ratiometric fluorescent pH sensors

Photochem. Photobiol. Sci., 2019, Accepted Manuscript
DOI: 10.1039/C8PP00457A, Paper

Chloé Grazon, Yang Si, Jean-Pierre Placial Marzin, Jutta Rieger, Rachel Meallet-Renault, Gilles Clavier
A new ratiometric fluorescent pH nanosensor is presented. It is based on ultrabright nanoparticles containing two spatially separated fluorophores: BODIPY covalently linked to the polystyrene core and fluorescein grafted to...
The content of this RSS Feed (c) The Royal Society of Chemistry

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://rsc.li/2SbiU63

Core-shell polymeric nanoparticles comprising BODIPY and fluorescein as ultra-bright ratiometric fluorescent pH sensors

Photochem. Photobiol. Sci., 2019, Accepted Manuscript
DOI: 10.1039/C8PP00457A, Paper

Chloé Grazon, Yang Si, Jean-Pierre Placial Marzin, Jutta Rieger, Rachel Meallet-Renault, Gilles Clavier
A new ratiometric fluorescent pH nanosensor is presented. It is based on ultrabright nanoparticles containing two spatially separated fluorophores: BODIPY covalently linked to the polystyrene core and fluorescein grafted to...
The content of this RSS Feed (c) The Royal Society of Chemistry

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://rsc.li/2SbiU63

Gallbladder Paraganglioma Associated with SDHD Mutation: a Potential Pitfall on 18 F-FDOPA PET Imaging

Abstract

A 36-year-old male patient initially presented with hypertension, tinnitus, bilateral carotid masses, a right jugular foramen, and a periaortic arch mass with an elevated plasma dopamine level but an otherwise normal biochemical profile. On surveillance MRI 4 years after initial presentation, he was found to have a 2.2-cm T2 hyperintense lesion with arterial enhancement adjacent to the gallbladder, which demonstrated avidity on ⁶⁸Ga-DOTATATE PET/CT and retrospectively on ¹⁸F-FDOPA PET/CT but was non-avid on ¹⁸F-FDG PET/CT. Biochemical work-up including plasma catecholamines, metanephrines, and chromogranin A levels were found to be within normal limits. This lesion was surgically resected and was confirmed to be a paraganglioma (PGL) originating from the gallbladder wall on histopathology. Pheochromocytoma (PHEO) and PGL are rare tumors of the autonomic nervous system. Succinate dehydrogenase subunit D (SDHD) pathogenic variants of the succinate dehydrogenase complex are usually involved in parasympathetic, extra-adrenal, multifocal head, and neck PGLs. We report an unusual location of PGL in the gallbladder associated with SDHD mutation which could present as a potential pitfall on ¹⁸F-FDOPA PET/CT as its normal excretion occurs through biliary system and gallbladder. This case highlights the superiority of ⁶⁸Ga-DOTATATE in comparison to ¹⁸F-FDOPA and ¹⁸F-FDG in the detection of SDHD-related parasympathetic PGL.

ClinicalTrials.gov Identifier: NCT00004847.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2IwLFui

Gallbladder Paraganglioma Associated with SDHD Mutation: a Potential Pitfall on 18 F-FDOPA PET Imaging

Abstract

A 36-year-old male patient initially presented with hypertension, tinnitus, bilateral carotid masses, a right jugular foramen, and a periaortic arch mass with an elevated plasma dopamine level but an otherwise normal biochemical profile. On surveillance MRI 4 years after initial presentation, he was found to have a 2.2-cm T2 hyperintense lesion with arterial enhancement adjacent to the gallbladder, which demonstrated avidity on ⁶⁸Ga-DOTATATE PET/CT and retrospectively on ¹⁸F-FDOPA PET/CT but was non-avid on ¹⁸F-FDG PET/CT. Biochemical work-up including plasma catecholamines, metanephrines, and chromogranin A levels were found to be within normal limits. This lesion was surgically resected and was confirmed to be a paraganglioma (PGL) originating from the gallbladder wall on histopathology. Pheochromocytoma (PHEO) and PGL are rare tumors of the autonomic nervous system. Succinate dehydrogenase subunit D (SDHD) pathogenic variants of the succinate dehydrogenase complex are usually involved in parasympathetic, extra-adrenal, multifocal head, and neck PGLs. We report an unusual location of PGL in the gallbladder associated with SDHD mutation which could present as a potential pitfall on ¹⁸F-FDOPA PET/CT as its normal excretion occurs through biliary system and gallbladder. This case highlights the superiority of ⁶⁸Ga-DOTATATE in comparison to ¹⁸F-FDOPA and ¹⁸F-FDG in the detection of SDHD-related parasympathetic PGL.

ClinicalTrials.gov Identifier: NCT00004847.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2IwLFui

Anesthetic Management of Nonobstetric Surgery during Pregnancy

Abstract

Purpose of Review

This article reviews several controversial aspects of management of nonobstetric surgery during pregnancy, including the optimal timing for nonurgent surgery, when to perform intraoperative fetal monitoring, modifications to anesthetic techniques to account for the physiologic changes of pregnancy, and management of maternal cardiac arrest.

Recent Findings

There have been several advances in the management of nonobstetric surgery during pregnancy, including the increased use of laparoscopic techniques, an improved understanding of the importance of adequate pain management, and new initiatives to improve the maternal cardiac resuscitation algorithm. Traditional dogma regarding aspiration prophylaxis during pregnancy and concerns about abortifacient and teratogenic properties of diagnostic imaging and anesthetic agents have also recently been reevaluated.

Summary

Urgent and emergent surgeries should proceed without delay during pregnancy in order to ensure optimal outcomes for both the mother and fetus. Anesthetic management may require several modifications to account for physiologic changes of pregnancy. In general, uteroplacental perfusion is best maintained by avoidance of maternal hypoxemia, hypotension, hyper- and hypocapnia, temperature extremes, and stress.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2TQApu9

How Do We Know? Comparisons of Existing Datasets for Overseas Surgical Missions

Abstract

Purpose of Review

Over five billion people lack access to safe surgery when they need it. Short-term surgical missions from high-resource countries are a popular strategy to try and address this deficit. Each year, thousands of providers spend billions of dollars participating in short-term surgical missions. These missions are poorly characterized in aggregate. In this exercise, we performed reviews of two databases in an attempt to identify and characterize short-term surgical missions to Uganda. The first, a traditional search of the medical literature. The second, an unorthodox search of the internet. We compare the results of each in terms of motive, trip length, operations performed, surgery type, country of origin, evidence of teaching, recurring missions, and year of mission.

Recent Findings

We found only one article in the academic literature that fits our criteria. We found 43 individual organizations responsible for 129 individual trips in our internet search. These are characterized in this paper.

Summary

The medical literature contains few traces of short-term surgical trips in Uganda. The internet contains many traces. These traces are rich in both qualitative and quantitative data. It is possible to mine, organize, and evaluate this data to better understand what is happening on the ground in Uganda and potentially the rest of the world.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2BHBi1f

Update on Obstetric Hemorrhage

Abstract

Purpose of Review

Postpartum hemorrhage is increasing in prevalence in the USA and continues to be an important cause of preventable maternal morbidity and mortality. This review provides the most recent epidemiologic data on postpartum hemorrhage in the USA, current nationwide initiatives for prevention, preparedness, and response to postpartum hemorrhage, and recent evidence-based advances in management.

Recent Findings

The National Partnership for Maternal Safety consensus bundle on obstetric hemorrhage serves as a resource for postpartum hemorrhage–related clinical and research initiatives. Areas of focus include standardizing postpartum hemorrhage management with protocol use, massive transfusion protocols, early and enhanced risk assessment, accurate quantitation of blood loss, and refined transfusion strategies such as early fibrinogen replacement, tranexamic acid therapy, and point of care testing to detect and treat coagulopathy.

Summary

Continued focus on improving the management of postpartum hemorrhage with available resources is imperative to minimize associated risks of morbidity and mortality.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2TWUdfg

Anesthetic Management of Nonobstetric Surgery during Pregnancy

Abstract

Purpose of Review

This article reviews several controversial aspects of management of nonobstetric surgery during pregnancy, including the optimal timing for nonurgent surgery, when to perform intraoperative fetal monitoring, modifications to anesthetic techniques to account for the physiologic changes of pregnancy, and management of maternal cardiac arrest.

Recent Findings

There have been several advances in the management of nonobstetric surgery during pregnancy, including the increased use of laparoscopic techniques, an improved understanding of the importance of adequate pain management, and new initiatives to improve the maternal cardiac resuscitation algorithm. Traditional dogma regarding aspiration prophylaxis during pregnancy and concerns about abortifacient and teratogenic properties of diagnostic imaging and anesthetic agents have also recently been reevaluated.

Summary

Urgent and emergent surgeries should proceed without delay during pregnancy in order to ensure optimal outcomes for both the mother and fetus. Anesthetic management may require several modifications to account for physiologic changes of pregnancy. In general, uteroplacental perfusion is best maintained by avoidance of maternal hypoxemia, hypotension, hyper- and hypocapnia, temperature extremes, and stress.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2TQApu9

How Do We Know? Comparisons of Existing Datasets for Overseas Surgical Missions

Abstract

Purpose of Review

Over five billion people lack access to safe surgery when they need it. Short-term surgical missions from high-resource countries are a popular strategy to try and address this deficit. Each year, thousands of providers spend billions of dollars participating in short-term surgical missions. These missions are poorly characterized in aggregate. In this exercise, we performed reviews of two databases in an attempt to identify and characterize short-term surgical missions to Uganda. The first, a traditional search of the medical literature. The second, an unorthodox search of the internet. We compare the results of each in terms of motive, trip length, operations performed, surgery type, country of origin, evidence of teaching, recurring missions, and year of mission.

Recent Findings

We found only one article in the academic literature that fits our criteria. We found 43 individual organizations responsible for 129 individual trips in our internet search. These are characterized in this paper.

Summary

The medical literature contains few traces of short-term surgical trips in Uganda. The internet contains many traces. These traces are rich in both qualitative and quantitative data. It is possible to mine, organize, and evaluate this data to better understand what is happening on the ground in Uganda and potentially the rest of the world.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2BHBi1f

Update on Obstetric Hemorrhage

Abstract

Purpose of Review

Postpartum hemorrhage is increasing in prevalence in the USA and continues to be an important cause of preventable maternal morbidity and mortality. This review provides the most recent epidemiologic data on postpartum hemorrhage in the USA, current nationwide initiatives for prevention, preparedness, and response to postpartum hemorrhage, and recent evidence-based advances in management.

Recent Findings

The National Partnership for Maternal Safety consensus bundle on obstetric hemorrhage serves as a resource for postpartum hemorrhage–related clinical and research initiatives. Areas of focus include standardizing postpartum hemorrhage management with protocol use, massive transfusion protocols, early and enhanced risk assessment, accurate quantitation of blood loss, and refined transfusion strategies such as early fibrinogen replacement, tranexamic acid therapy, and point of care testing to detect and treat coagulopathy.

Summary

Continued focus on improving the management of postpartum hemorrhage with available resources is imperative to minimize associated risks of morbidity and mortality.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2TWUdfg

Three-dimensional analysis of nasolabial soft tissue changes after Le Fort I osteotomy: a systematic review of the literature

A systematic review was conducted to investigate the three-dimensional (3D) effect of Le Fort I osteotomy on the nasolabial soft tissues. The literature search was conducted using the MEDLINE (accessed via PubMed), Embase, and Cochrane electronic databases until January 2018. A total of 333 studies were identified (PubMed, n=292; Embase, n=41; Cochrane Library, n=0). Seventeen met the inclusion criteria. The studies were essentially retrospective. The risk of bias was considered high in 15 studies, medium in one study, and low in one study. (Source: International Journal of Oral and Maxillofacial Surgery)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2BFBZbm

Idiopathic bone cavity of the jaws: an updated analysis of the cases reported in the literature

The aim of this systematic review was to compare the clinical and radiological features of solitary and multiple idiopathic bone cavities (IBCs) reported in the jaws, as well as to identify possible features that may have some influence on the frequency of persistence of IBC following treatment. An electronic search was undertaken in August 2018. Eligibility criteria included publications with sufficient clinical, radiological, and histological information to confirm the diagnosis. A total of 284 publications reporting 1253 IBCs were included. (Source: International Journal of Oral and Maxillofacial Surgery)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2TYkkCI

Three-dimensional analysis of nasolabial soft tissue changes after Le Fort I osteotomy: a systematic review of the literature

A systematic review was conducted to investigate the three-dimensional (3D) effect of Le Fort I osteotomy on the nasolabial soft tissues. The literature search was conducted using the MEDLINE (accessed via PubMed), Embase, and Cochrane electronic databases until January 2018. A total of 333 studies were identified (PubMed, n=292; Embase, n=41; Cochrane Library, n=0). Seventeen met the inclusion criteria. The studies were essentially retrospective. The risk of bias was considered high in 15 studies, medium in one study, and low in one study. (Source: International Journal of Oral and Maxillofacial Surgery)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2BFBZbm

Idiopathic bone cavity of the jaws: an updated analysis of the cases reported in the literature

The aim of this systematic review was to compare the clinical and radiological features of solitary and multiple idiopathic bone cavities (IBCs) reported in the jaws, as well as to identify possible features that may have some influence on the frequency of persistence of IBC following treatment. An electronic search was undertaken in August 2018. Eligibility criteria included publications with sufficient clinical, radiological, and histological information to confirm the diagnosis. A total of 284 publications reporting 1253 IBCs were included. (Source: International Journal of Oral and Maxillofacial Surgery)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2TYkkCI

Brain Stem and Audio-Vestibular Regulation

AbstractThe central pathologies present with perverted auditory perception and compromised postural control. Considering the existing controversy this study involves assessments of 100 cases of post fossa tumefactions in which a detailed clinical and neuro-otological (pure tone audiometry, electronystagmography, brainstem evoked response audiometry) profile is compared with their imaging patterns. The CP angle schwannomas (N  = 26) presented with abnormal speech tests (N = 18), abnormal auditory adaptation (N = 7) and ABR with pathologically increased latency of wave V (N = 32), poor formation of wave I (N = 31) along with abnormal inter-wave interval (N = 32). In lesions (N = 32) compressing deeper nuclei, vermis and axial parts of brain stem, a gross truncal a...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2EiRMhT

Sinonasal Inverted Papilloma: Efficacy of Demucosation to Reduce Recurrence After Surgical Managements

AbstractTo compare the outcomes of various surgical approaches to resect sinonasal inverted papilloma and to discuss their advantages and disadvantages. A retrospective chart review of 61 consecutive patients with sinonasal inverted papilloma was performed. Surgical treatment included non-demucosation endoscopic sinus surgery (ESS), demucosation ESS, endonasal medial maxillectomy (EMM), Draf type 3, Caldwell-Luc surgery, Denker, Killian, and lateral rhinotomy. Recurrence rates were compared between endonasal and external approaches and between demucosation and non-demucosation. After the first curative surgery, the non-demucosation ESS, endonasal demucosation (demucosation ESS, EMM, and Draf type 3), and external surgery showed recurrence rates of 61.5%, (8/13), 0.0% (0/21), and 7.4% (2/27...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Gy3XKe

Brain Stem and Audio-Vestibular Regulation

AbstractThe central pathologies present with perverted auditory perception and compromised postural control. Considering the existing controversy this study involves assessments of 100 cases of post fossa tumefactions in which a detailed clinical and neuro-otological (pure tone audiometry, electronystagmography, brainstem evoked response audiometry) profile is compared with their imaging patterns. The CP angle schwannomas (N  = 26) presented with abnormal speech tests (N = 18), abnormal auditory adaptation (N = 7) and ABR with pathologically increased latency of wave V (N = 32), poor formation of wave I (N = 31) along with abnormal inter-wave interval (N = 32). In lesions (N = 32) compressing deeper nuclei, vermis and axial parts of brain stem, a gross truncal a...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2EiRMhT

Sinonasal Inverted Papilloma: Efficacy of Demucosation to Reduce Recurrence After Surgical Managements

AbstractTo compare the outcomes of various surgical approaches to resect sinonasal inverted papilloma and to discuss their advantages and disadvantages. A retrospective chart review of 61 consecutive patients with sinonasal inverted papilloma was performed. Surgical treatment included non-demucosation endoscopic sinus surgery (ESS), demucosation ESS, endonasal medial maxillectomy (EMM), Draf type 3, Caldwell-Luc surgery, Denker, Killian, and lateral rhinotomy. Recurrence rates were compared between endonasal and external approaches and between demucosation and non-demucosation. After the first curative surgery, the non-demucosation ESS, endonasal demucosation (demucosation ESS, EMM, and Draf type 3), and external surgery showed recurrence rates of 61.5%, (8/13), 0.0% (0/21), and 7.4% (2/27...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Gy3XKe

Brain Stem and Audio-Vestibular Regulation

AbstractThe central pathologies present with perverted auditory perception and compromised postural control. Considering the existing controversy this study involves assessments of 100 cases of post fossa tumefactions in which a detailed clinical and neuro-otological (pure tone audiometry, electronystagmography, brainstem evoked response audiometry) profile is compared with their imaging patterns. The CP angle schwannomas (N  = 26) presented with abnormal speech tests (N = 18), abnormal auditory adaptation (N = 7) and ABR with pathologically increased latency of wave V (N = 32), poor formation of wave I (N = 31) along with abnormal inter-wave interval (N = 32). In lesions (N = 32) compressing deeper nuclei, vermis and axial parts of brain stem, a gross truncal a...

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2EiRMhT

Audiological outcome for hearing preservation surgery in acoustic neuroma: the need of agreement in reporting results

. (Source: Hearing, Balance and Communication)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2GQdKdI

Benefit of directional microphones for unilateral, bilateral and bimodal cochlear implant users

. (Source: Cochlear Implants International)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2EfWmxe

Cochlear implantation via middle fossa approach – a case report

. (Source: Cochlear Implants International)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2GLng1T

Brain Stem and Audio-Vestibular Regulation

AbstractThe central pathologies present with perverted auditory perception and compromised postural control. Considering the existing controversy this study involves assessments of 100 cases of post fossa tumefactions in which a detailed clinical and neuro-otological (pure tone audiometry, electronystagmography, brainstem evoked response audiometry) profile is compared with their imaging patterns. The CP angle schwannomas (N  = 26) presented with abnormal speech tests (N = 18), abnormal auditory adaptation (N = 7) and ABR with pathologically increased latency of wave V (N = 32), poor formation of wave I (N = 31) along with abnormal inter-wave interval (N = 32). In lesions (N = 32) compressing deeper nuclei, vermis and axial parts of brain stem, a gross truncal a...

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2EiRMhT

Audiological outcome for hearing preservation surgery in acoustic neuroma: the need of agreement in reporting results

. (Source: Hearing, Balance and Communication)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2GQdKdI

Benefit of directional microphones for unilateral, bilateral and bimodal cochlear implant users

. (Source: Cochlear Implants International)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2EfWmxe

Cochlear implantation via middle fossa approach – a case report

. (Source: Cochlear Implants International)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2GLng1T

Glutathione-S-transferase mu-1 null genotype increases wood smoke-induced airway inflammation

A 2-hour exposure to 500 μg/m3 wood smoke particles caused neutrophilic airway inflammation in human volunteers, with GSTM1 null genotype being associated with greater inflammatory response to this pollutant. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2IkgeDy

Treatments of Cold Urticaria: A Systematic Review

Modern, second-generation H1-antihistamines at standard and up to fourfold dosages, as well as 150- and 300-mg dosages of omalizumab, are safe and effective in the treatment of cold urticaria. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2T6WGHa

HLA-A*32:01 is strongly associated with vancomycin-induced drug reaction with eosinophilia and systemic symptoms

In a population of predominantly European ancestry, we show that carriage of the HLA-A*32:01 allele is strongly associated with the development of vancomycin DRESS. HLA-A*32:01 testing could increase the safety of vancomycin treatment. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Inqawh

High Comorbidity Burden and Rates of Severe Reactions in Young Patients With Peanut Allergy

Peanut allergy (PA) has significant impact on quality of life (QoL) of patients and their families. Comorbidity and poly-allergy disease burden in these patients has not been adequately described. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2T6WGa8

Glutathione-S-transferase mu-1 null genotype increases wood smoke-induced airway inflammation

A 2-hour exposure to 500 μg/m3 wood smoke particles caused neutrophilic airway inflammation in human volunteers, with GSTM1 null genotype being associated with greater inflammatory response to this pollutant. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2IkgeDy

Treatments of Cold Urticaria: A Systematic Review

Modern, second-generation H1-antihistamines at standard and up to fourfold dosages, as well as 150- and 300-mg dosages of omalizumab, are safe and effective in the treatment of cold urticaria. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2T6WGHa

HLA-A*32:01 is strongly associated with vancomycin-induced drug reaction with eosinophilia and systemic symptoms

In a population of predominantly European ancestry, we show that carriage of the HLA-A*32:01 allele is strongly associated with the development of vancomycin DRESS. HLA-A*32:01 testing could increase the safety of vancomycin treatment. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Inqawh

High Comorbidity Burden and Rates of Severe Reactions in Young Patients With Peanut Allergy

Peanut allergy (PA) has significant impact on quality of life (QoL) of patients and their families. Comorbidity and poly-allergy disease burden in these patients has not been adequately described. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2T6WGa8

The spritz of aftershave that could've killed me...because I've got a FOOD allergy!

Julianne Ponan, from Walton-on-Thames, Surrey, was left fighting for her life after she received a hug from her father, who was wearing cologne. Here, she reveals how to manage life with allergies. (Source: the Mail online | Health)

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2V1QkG8

The spritz of aftershave that could've killed me...because I've got a FOOD allergy!

Julianne Ponan, from Walton-on-Thames, Surrey, was left fighting for her life after she received a hug from her father, who was wearing cologne. Here, she reveals how to manage life with allergies. (Source: the Mail online | Health)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2V1QkG8

The spritz of aftershave that could've killed me...because I've got a FOOD allergy!

Julianne Ponan, from Walton-on-Thames, Surrey, was left fighting for her life after she received a hug from her father, who was wearing cologne. Here, she reveals how to manage life with allergies. (Source: the Mail online | Health)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2V1QkG8

The spritz of aftershave that could've killed me...because I've got a FOOD allergy!

Julianne Ponan, from Walton-on-Thames, Surrey, was left fighting for her life after she received a hug from her father, who was wearing cologne. Here, she reveals how to manage life with allergies. (Source: the Mail online | Health)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

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Benigne Raumforderung der Glandula parotis – eine seltene Differentialdiagnose

Laryngo-Rhino-Otol
DOI: 10.1055/a-0839-5241

© Georg Thieme Verlag KG Stuttgart · New York

Article in Thieme eJournals:
Table of contents  |  Full text

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Nbjtfg

Benigne Raumforderung der Glandula parotis – eine seltene Differentialdiagnose

Laryngo-Rhino-Otol
DOI: 10.1055/a-0839-5241

© Georg Thieme Verlag KG Stuttgart · New York

Article in Thieme eJournals:
Table of contents  |  Full text

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Nbjtfg

Risk factors of intracranial hemorrhage after mechanical thrombectomy of anterior circulation ischemic stroke

Abstract

Purpose

Intracranial hemorrhage (ICH) is a potentially severe complication after mechanical thrombectomy (MT). Here, we investigated risk factors for the occurrence of any and symptomatic ICH after MT due to large-vessel occlusion of the anterior circulation.

Methods

Consecutive patients with acute ischemic anterior circulation stroke with large-vessel occlusion undergoing MT were analyzed. ICH was categorized according to the Heidelberg Bleeding Classification. Forty-three procedural and clinical parameters were analyzed using univariate tests and multivariate logistic regressions.

Results

Of 612 patients, any ICH was detected in 195 (31.9%), while 27 (4.4%) developed a symptomatic ICH. Infarct size > 1/3 of vascular territory in control imaging (OR 2.18, 95% CI 1.45–3.21), higher serum glucose levels (OR 1.23 for change of 15 units mg/dL, 95% CI 1.10–1.39), and higher thrombectomy maneuver count (OR 1.21, 95% CI 1.11–1.32) were significantly associated with a higher risk of developing any ICH compared to no ICH. Wake-up strokes (OR 3.99, 95% CI 1.38–11.60), transfer from an external clinic (OR 3.04, 95% CI 1.24–7.48), and higher serum glucose levels (OR 1.22 for change of 15 units mg/dL, 95% CI 1.05–1.42) were revealed as independent risk factors for development of symptomatic ICH compared to no symptomatic ICH. Patients with no infarct demarcation (OR 0.10, 95% CI 0.01–0.80) and complete recanalization (OR 0.57, 95% CI 0.37–0.86) showed a lower risk of developing any ICH.

Conclusion

Wake-up strokes and patients who are treated within a drip-and-ship concept are especially vulnerable for symptomatic ICH, while complete recanalization, contrary to subtotal recanalization only, was revealed as a protective factor against ICH.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2GPwo5n

Symptomatic Schmorl’s nodes: role of percutaneous vertebroplasty. Open study on 52 patients

Abstract

Purpose

To assess the feasibility and clinical outcome of combined CT and fluoroscopy-guided percutaneous vertebroplasty in the management of painful Schmorl's nodes (SN).

Methods

A prospective study was carried out from January 2014 to January 2016 in 52 consecutive patients. Thirty-two men and 30 women aged between 42 and 88 years old were consecutively included. Technical success was defined as the ability to deposit cement in the subchondral endplate anteriorly, around the SN and posteriorly to the SN, in a cupule-like shape. Data regarding procedure time, amount of cement injection, and cement leakage were also noted. Assessment of pain was performed with VAS score and Oswestry disability index. All patients underwent a clinical and radiological follow-up at 1 day, 1 month, 6 months, and 1 year after procedure.

Results

Technical success was 100%. Mean procedural time was 15 min, and mean injected cement volume was 2.8 mL. The VAS and Oswestry disability index decreased respectively from 7.2 ± 1.5 to 2.1 ± 1.0 and from 59.2 ± 16.2 to 17.1 ± 5.0 at 1 month. Follow-up mean VAS scores were 2.4 (± 1.4) at 6 months and 2.2 (± 1.2) at 12 months.

Conclusion

PVP appears as a feasible procedure in patients with painful SN with satisfying pain decrease in the following year after procedure.

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Risk factors of intracranial hemorrhage after mechanical thrombectomy of anterior circulation ischemic stroke

Abstract

Purpose

Intracranial hemorrhage (ICH) is a potentially severe complication after mechanical thrombectomy (MT). Here, we investigated risk factors for the occurrence of any and symptomatic ICH after MT due to large-vessel occlusion of the anterior circulation.

Methods

Consecutive patients with acute ischemic anterior circulation stroke with large-vessel occlusion undergoing MT were analyzed. ICH was categorized according to the Heidelberg Bleeding Classification. Forty-three procedural and clinical parameters were analyzed using univariate tests and multivariate logistic regressions.

Results

Of 612 patients, any ICH was detected in 195 (31.9%), while 27 (4.4%) developed a symptomatic ICH. Infarct size > 1/3 of vascular territory in control imaging (OR 2.18, 95% CI 1.45–3.21), higher serum glucose levels (OR 1.23 for change of 15 units mg/dL, 95% CI 1.10–1.39), and higher thrombectomy maneuver count (OR 1.21, 95% CI 1.11–1.32) were significantly associated with a higher risk of developing any ICH compared to no ICH. Wake-up strokes (OR 3.99, 95% CI 1.38–11.60), transfer from an external clinic (OR 3.04, 95% CI 1.24–7.48), and higher serum glucose levels (OR 1.22 for change of 15 units mg/dL, 95% CI 1.05–1.42) were revealed as independent risk factors for development of symptomatic ICH compared to no symptomatic ICH. Patients with no infarct demarcation (OR 0.10, 95% CI 0.01–0.80) and complete recanalization (OR 0.57, 95% CI 0.37–0.86) showed a lower risk of developing any ICH.

Conclusion

Wake-up strokes and patients who are treated within a drip-and-ship concept are especially vulnerable for symptomatic ICH, while complete recanalization, contrary to subtotal recanalization only, was revealed as a protective factor against ICH.

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Symptomatic Schmorl’s nodes: role of percutaneous vertebroplasty. Open study on 52 patients

Abstract

Purpose

To assess the feasibility and clinical outcome of combined CT and fluoroscopy-guided percutaneous vertebroplasty in the management of painful Schmorl's nodes (SN).

Methods

A prospective study was carried out from January 2014 to January 2016 in 52 consecutive patients. Thirty-two men and 30 women aged between 42 and 88 years old were consecutively included. Technical success was defined as the ability to deposit cement in the subchondral endplate anteriorly, around the SN and posteriorly to the SN, in a cupule-like shape. Data regarding procedure time, amount of cement injection, and cement leakage were also noted. Assessment of pain was performed with VAS score and Oswestry disability index. All patients underwent a clinical and radiological follow-up at 1 day, 1 month, 6 months, and 1 year after procedure.

Results

Technical success was 100%. Mean procedural time was 15 min, and mean injected cement volume was 2.8 mL. The VAS and Oswestry disability index decreased respectively from 7.2 ± 1.5 to 2.1 ± 1.0 and from 59.2 ± 16.2 to 17.1 ± 5.0 at 1 month. Follow-up mean VAS scores were 2.4 (± 1.4) at 6 months and 2.2 (± 1.2) at 12 months.

Conclusion

PVP appears as a feasible procedure in patients with painful SN with satisfying pain decrease in the following year after procedure.

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Successful Mandibular MucormycosisTreatment in the Severe Neutropenic Patient

Mucormycosis is a rare opportunistic and aggressive deep fungal infection that predominantly affects immunocompromised patients and its mortality rate has been reported to be up to 80%.Typing of the infection is based mainly on the clinical and anatomical presentation, the most common being rhino-cerebral type.We present three cases of oncology patients who had successful treatment of mandibular mucormycosis. Chemotherapy was administered 13-30 days prior to diagnosis of the infection, resulting in neutropenia in all patients.

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Successful Mandibular MucormycosisTreatment in the Severe Neutropenic Patient

Mucormycosis is a rare opportunistic and aggressive deep fungal infection that predominantly affects immunocompromised patients and its mortality rate has been reported to be up to 80%.Typing of the infection is based mainly on the clinical and anatomical presentation, the most common being rhino-cerebral type.We present three cases of oncology patients who had successful treatment of mandibular mucormycosis. Chemotherapy was administered 13-30 days prior to diagnosis of the infection, resulting in neutropenia in all patients.

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Idiopathic bone cavity of the jaws: an updated analysis of the cases reported in the literature

The aim of this systematic review was to compare the clinical and radiological features of solitary and multiple idiopathic bone cavities (IBCs) reported in the jaws, as well as to identify possible features that may have some influence on the frequency of persistence of IBC following treatment. An electronic search was undertaken in August 2018. Eligibility criteria included publications with sufficient clinical, radiological, and histological information to confirm the diagnosis. A total of 284 publications reporting 1253 IBCs were included.

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Three-dimensional analysis of nasolabial soft tissue changes after Le Fort I osteotomy: a systematic review of the literature

A systematic review was conducted to investigate the three-dimensional (3D) effect of Le Fort I osteotomy on the nasolabial soft tissues. The literature search was conducted using the MEDLINE (accessed via PubMed), Embase, and Cochrane electronic databases until January 2018. A total of 333 studies were identified (PubMed, n=292; Embase, n=41; Cochrane Library, n=0). Seventeen met the inclusion criteria. The studies were essentially retrospective. The risk of bias was considered high in 15 studies, medium in one study, and low in one study.

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Successful Mandibular MucormycosisTreatment in the Severe Neutropenic Patient

Mucormycosis is a rare opportunistic and aggressive deep fungal infection that predominantly affects immunocompromised patients and its mortality rate has been reported to be up to 80%.Typing of the infection is based mainly on the clinical and anatomical presentation, the most common being rhino-cerebral type.We present three cases of oncology patients who had successful treatment of mandibular mucormycosis. Chemotherapy was administered 13-30 days prior to diagnosis of the infection, resulting in neutropenia in all patients.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2NbDCSs

Idiopathic bone cavity of the jaws: an updated analysis of the cases reported in the literature

The aim of this systematic review was to compare the clinical and radiological features of solitary and multiple idiopathic bone cavities (IBCs) reported in the jaws, as well as to identify possible features that may have some influence on the frequency of persistence of IBC following treatment. An electronic search was undertaken in August 2018. Eligibility criteria included publications with sufficient clinical, radiological, and histological information to confirm the diagnosis. A total of 284 publications reporting 1253 IBCs were included.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2NbROLg

Three-dimensional analysis of nasolabial soft tissue changes after Le Fort I osteotomy: a systematic review of the literature

A systematic review was conducted to investigate the three-dimensional (3D) effect of Le Fort I osteotomy on the nasolabial soft tissues. The literature search was conducted using the MEDLINE (accessed via PubMed), Embase, and Cochrane electronic databases until January 2018. A total of 333 studies were identified (PubMed, n=292; Embase, n=41; Cochrane Library, n=0). Seventeen met the inclusion criteria. The studies were essentially retrospective. The risk of bias was considered high in 15 studies, medium in one study, and low in one study.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2GwiZQw

Successful Mandibular MucormycosisTreatment in the Severe Neutropenic Patient

Mucormycosis is a rare opportunistic and aggressive deep fungal infection that predominantly affects immunocompromised patients and its mortality rate has been reported to be up to 80%.Typing of the infection is based mainly on the clinical and anatomical presentation, the most common being rhino-cerebral type.We present three cases of oncology patients who had successful treatment of mandibular mucormycosis. Chemotherapy was administered 13-30 days prior to diagnosis of the infection, resulting in neutropenia in all patients.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2NbDCSs

Medical News Today: Is it allergic asthma or something else?

Allergic asthma occurs when people are around certain triggers. Symptoms may include chest tightness. Treatment may be possible at home or with lifestyle changes. Learn more here. (Source: Health News from Medical News Today)

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New Allergy Treatment Program Aims to Improve Patient Care and Reduce...

Through an investment in Xtract Solutions, a software provider for hospitals and allergy clinics, Edge Pharmacy Services creates the first complete solution to provide compliant immunotherapy. The...(PRWeb February 18, 2019)Read the full story at http://bit.ly/2Ij6DNu (Source: PRWeb: Medical Pharmaceuticals)

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Medical News Today: Is it allergic asthma or something else?

Allergic asthma occurs when people are around certain triggers. Symptoms may include chest tightness. Treatment may be possible at home or with lifestyle changes. Learn more here. (Source: Health News from Medical News Today)

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New Allergy Treatment Program Aims to Improve Patient Care and Reduce...

Through an investment in Xtract Solutions, a software provider for hospitals and allergy clinics, Edge Pharmacy Services creates the first complete solution to provide compliant immunotherapy. The...(PRWeb February 18, 2019)Read the full story at http://bit.ly/2Ij6DNu (Source: PRWeb: Medical Pharmaceuticals)

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Impact of UV-B radiation on the photosystem II activity, pro-/antioxidant balance and expression of light-activated genes in Arabidopsis thaliana hy4 mutants grown under light of different spectral composition

Publication date: Available online 18 February 2019Source: Journal of Photochemistry and Photobiology B: BiologyAuthor(s): Aleksandra Yu Khudyakova, Vladimir D. Kreslavski, Aleksandr N. Shmarev, Valery Yu Lyubimov, Galina N. Shirshikova, Pavel P. Pashkovskiy, Vladimir V. Kuznetsov, Suleyman I. AllahverdievAbstractThe effect of UV-B irradiation on the photosystem II (PSII) activity, the content of photosynthetic and UV-absorbing pigments (UAPs), activity of antioxidant enzymes such as catalase (CAT) and peroxidase (POD), as well as H2O2 content in 25-day-old wild type (WT) and the cryptochrome 1 (Cry1) mutant hy4 of Arabidopsis thaliana Col-0 plants was studied. In addition, expression of photoreceptor genes Cry1, Cry2 and UVR8, photomorphogenetic gene COP1 and transcription factors genes H...

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Corrigendum to ‘Working memory training involves learning new skills’. [J. Memory Language 105 (2019) 19–42]

Publication date: Available online 18 February 2019Source: Journal of Memory and LanguageAuthor(s): Susan E. Gathercole, Darren L. Dunning, Joni Holmes, Dennis Norris (Source: Journal of Memory and Language)

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Learning Phonology from Surface Distributions, Considering Dutch and English Vowel Duration

. (Source: Language Learning and Development)

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Towards Abstract Syntax at 24 Months: Evidence from Subject-Verb Agreement with Conjoined Subjects

. (Source: Language Learning and Development)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2BIyhxq

Lexical stress in childhood apraxia of speech: acoustic and kinematic findings

. (Source: International Journal of Speech-Language Pathology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2TY41Ww

Analysis of behavioural characteristics of children with developmental language disorders

. (Source: International Journal of Speech-Language Pathology)

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Do Children Recall Numbers as Generic? A Strong Test of the Generics-As-Default Hypothesis

. (Source: Language Learning and Development)

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Proton transfer fluorescent secondary amines. Synthesis, photophysics, theoretical calculation and preparation of photoactive phosphatidylcholine-based liposomes

Photochem. Photobiol. Sci., 2019, Accepted Manuscript
DOI: 10.1039/C9PP00017H, Paper

Thais Kroetz, Marinalva Cardoso dos Santos, Roiney Beal, Gabriel Zanotto, Fabiano S Santos, Fernando Carlos Giacomelli, Paulo F.B. Goncalves, Vânia Rodrigues de Lima, Alexandre Gonçalves Dal Bó, Fabiano Severo Rodembusch
In this article, new fluorescent lipophilic based benzazoles were synthesized from the reaction between photoactive formyl derivatives and aliphatic amines followed by NaBH₄ reduction with good yields. The photophysics of...
The content of this RSS Feed (c) The Royal Society of Chemistry

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Medical News Today: Is it allergic asthma or something else?

Allergic asthma occurs when people are around certain triggers. Symptoms may include chest tightness. Treatment may be possible at home or with lifestyle changes. Learn more here. (Source: Health News from Medical News Today)

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New Allergy Treatment Program Aims to Improve Patient Care and Reduce...

Through an investment in Xtract Solutions, a software provider for hospitals and allergy clinics, Edge Pharmacy Services creates the first complete solution to provide compliant immunotherapy. The...(PRWeb February 18, 2019)Read the full story at http://bit.ly/2Ij6DNu (Source: PRWeb: Medical Pharmaceuticals)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2TRvgCc

Impact of UV-B radiation on the photosystem II activity, pro-/antioxidant balance and expression of light-activated genes in Arabidopsis thaliana hy4 mutants grown under light of different spectral composition

Publication date: Available online 18 February 2019Source: Journal of Photochemistry and Photobiology B: BiologyAuthor(s): Aleksandra Yu Khudyakova, Vladimir D. Kreslavski, Aleksandr N. Shmarev, Valery Yu Lyubimov, Galina N. Shirshikova, Pavel P. Pashkovskiy, Vladimir V. Kuznetsov, Suleyman I. AllahverdievAbstractThe effect of UV-B irradiation on the photosystem II (PSII) activity, the content of photosynthetic and UV-absorbing pigments (UAPs), activity of antioxidant enzymes such as catalase (CAT) and peroxidase (POD), as well as H2O2 content in 25-day-old wild type (WT) and the cryptochrome 1 (Cry1) mutant hy4 of Arabidopsis thaliana Col-0 plants was studied. In addition, expression of photoreceptor genes Cry1, Cry2 and UVR8, photomorphogenetic gene COP1 and transcription factors genes H...

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2TVoJq9

Corrigendum to ‘Working memory training involves learning new skills’. [J. Memory Language 105 (2019) 19–42]

Publication date: Available online 18 February 2019Source: Journal of Memory and LanguageAuthor(s): Susan E. Gathercole, Darren L. Dunning, Joni Holmes, Dennis Norris (Source: Journal of Memory and Language)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2BH791L

Learning Phonology from Surface Distributions, Considering Dutch and English Vowel Duration

. (Source: Language Learning and Development)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2TWvvM2

Towards Abstract Syntax at 24 Months: Evidence from Subject-Verb Agreement with Conjoined Subjects

. (Source: Language Learning and Development)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2BIyhxq

Lexical stress in childhood apraxia of speech: acoustic and kinematic findings

. (Source: International Journal of Speech-Language Pathology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2TY41Ww

Analysis of behavioural characteristics of children with developmental language disorders

. (Source: International Journal of Speech-Language Pathology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2BFwDNe

Do Children Recall Numbers as Generic? A Strong Test of the Generics-As-Default Hypothesis

. (Source: Language Learning and Development)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2TVlD5x

Proton transfer fluorescent secondary amines. Synthesis, photophysics, theoretical calculation and preparation of photoactive phosphatidylcholine-based liposomes

Photochem. Photobiol. Sci., 2019, Accepted Manuscript
DOI: 10.1039/C9PP00017H, Paper

Thais Kroetz, Marinalva Cardoso dos Santos, Roiney Beal, Gabriel Zanotto, Fabiano S Santos, Fernando Carlos Giacomelli, Paulo F.B. Goncalves, Vânia Rodrigues de Lima, Alexandre Gonçalves Dal Bó, Fabiano Severo Rodembusch
In this article, new fluorescent lipophilic based benzazoles were synthesized from the reaction between photoactive formyl derivatives and aliphatic amines followed by NaBH₄ reduction with good yields. The photophysics of...
The content of this RSS Feed (c) The Royal Society of Chemistry

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Medical News Today: Is it allergic asthma or something else?

Allergic asthma occurs when people are around certain triggers. Symptoms may include chest tightness. Treatment may be possible at home or with lifestyle changes. Learn more here. (Source: Health News from Medical News Today)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

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New Allergy Treatment Program Aims to Improve Patient Care and Reduce...

Through an investment in Xtract Solutions, a software provider for hospitals and allergy clinics, Edge Pharmacy Services creates the first complete solution to provide compliant immunotherapy. The...(PRWeb February 18, 2019)Read the full story at http://bit.ly/2Ij6DNu (Source: PRWeb: Medical Pharmaceuticals)

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Glutathione-S-transferase mu-1 null genotype increases wood smoke-induced airway inflammation

A 2-hour exposure to 500 μg/m3 wood smoke particles caused neutrophilic airway inflammation in human volunteers, with GSTM1 null genotype being associated with greater inflammatory response to this pollutant.

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Glutathione-S-transferase mu-1 null genotype increases wood smoke-induced airway inflammation

A 2-hour exposure to 500 μg/m3 wood smoke particles caused neutrophilic airway inflammation in human volunteers, with GSTM1 null genotype being associated with greater inflammatory response to this pollutant.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2ImjqPa

Sinonasal Inverted Papilloma: Efficacy of Demucosation to Reduce Recurrence After Surgical Managements

Abstract

To compare the outcomes of various surgical approaches to resect sinonasal inverted papilloma and to discuss their advantages and disadvantages. A retrospective chart review of 61 consecutive patients with sinonasal inverted papilloma was performed. Surgical treatment included non-demucosation endoscopic sinus surgery (ESS), demucosation ESS, endonasal medial maxillectomy (EMM), Draf type 3, Caldwell-Luc surgery, Denker, Killian, and lateral rhinotomy. Recurrence rates were compared between endonasal and external approaches and between demucosation and non-demucosation. After the first curative surgery, the non-demucosation ESS, endonasal demucosation (demucosation ESS, EMM, and Draf type 3), and external surgery showed recurrence rates of 61.5%, (8/13), 0.0% (0/21), and 7.4% (2/27), respectively. A significantly lower recurrence rate was observed in the endonasal demucosation (p < 0.001) and in the demucosation ESS group (p < 0.001) in comparison with the non-demucosation ESS. However, as for recurrence rate, no statistically significant difference was observed between endonasal surgery and external surgery (p = 0.162). Demucosation is a better strategy for the treatment of inverted papilloma than is non-demucosation. Demucosation is the key procedure for preventing recurrence.

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Sinonasal Inverted Papilloma: Efficacy of Demucosation to Reduce Recurrence After Surgical Managements

Abstract

To compare the outcomes of various surgical approaches to resect sinonasal inverted papilloma and to discuss their advantages and disadvantages. A retrospective chart review of 61 consecutive patients with sinonasal inverted papilloma was performed. Surgical treatment included non-demucosation endoscopic sinus surgery (ESS), demucosation ESS, endonasal medial maxillectomy (EMM), Draf type 3, Caldwell-Luc surgery, Denker, Killian, and lateral rhinotomy. Recurrence rates were compared between endonasal and external approaches and between demucosation and non-demucosation. After the first curative surgery, the non-demucosation ESS, endonasal demucosation (demucosation ESS, EMM, and Draf type 3), and external surgery showed recurrence rates of 61.5%, (8/13), 0.0% (0/21), and 7.4% (2/27), respectively. A significantly lower recurrence rate was observed in the endonasal demucosation (p < 0.001) and in the demucosation ESS group (p < 0.001) in comparison with the non-demucosation ESS. However, as for recurrence rate, no statistically significant difference was observed between endonasal surgery and external surgery (p = 0.162). Demucosation is a better strategy for the treatment of inverted papilloma than is non-demucosation. Demucosation is the key procedure for preventing recurrence.

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18 F-FDG and 18 F-FAMT PET-derived metabolic parameters predict outcome of oral squamous cell carcinoma

Abstract

Objectives

L-3-[¹⁸F]-Fluoro-α-methyl tyrosine (FAMT), an amino acid positron emission tomography (PET) tracer, complements [¹⁸F]-fluorodeoxyglucose (FDG) in the diagnosis of malignancies. We compared the predictive ability of FAMT PET versus FDG PET regarding metastatic oral squamous cell carcinoma (OSCC) outcomes for distant metastasis, including lymph node metastasis, and identified the relevant metabolic parameters for each.

Methods

We enrolled 160 patients with OSCC who underwent PET/computed tomography using FDG and FAMT before treatment. Outcomes were assessed using clinicopathological characteristics such as the standardized uptake value (SUV_max, SUV_peak), metabolic tumor volume (MTV), and total lesion glycolysis or total lesion retention. Univariate and multivariate Cox proportional hazards models were used to identify the independent predictors of disease-free survival (DFS) and overall survival (OS) during an average follow-up time of 1401.7 and 1646.0 days, respectively. Areas under the receiver operating characteristic curves were analyzed for the accuracy and predictive value of imaging parameters.

Results

Clinical parameters (excluding age) and PET metabolic parameters were significantly associated with OS. Multivariate analysis showed that an infiltrative growth pattern [p = 0.034, hazard ratio (HR) = 2.30], and the FDG-measured SUV_peak (p = 0.045, HR = 2.45) were independent risk factors for DFS and that lymph node metastasis (p = 0.03, HR = 2.57) and the FAMT-measured MTV (p = 0.004, HR = 3.65) were independent risk factors for OS.

Conclusions

In patients with OSCC, FDG PET predicted DFS, whereas FAMT predicted OS. The two PET tracers, combined with clinical parameters, provide complementary, outcome-related diagnostic information in OSCC.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2EiGKcB

Hearing interventions to prevent dementia.

Authors: Dawes P Abstract Hearing loss is a marker of risk for cognitive decline and dementia. Controlled hearing intervention studies of long-term cognitive outcomes are challenging, and thus the evidence for the impact of hearing interventions is primarily from observational studies and will likely continue to be from studies other than randomised controlled trials. Seven studies of hearing interventions with cognitive outcomes assessed over longer than 3 years are reviewed. Most were of low-to-moderate quality. One cochlear implant study had indeterminate findings. Of six hearing aid studies, three reported a positive impact of hearing aid use while three reported no impact of hearing aid use on cognitive decline or incident cognitive impairment. Further studies are requir...

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Eph/ephrin signalling in the development and function of the mammalian cochlea.

Authors: Defourny J Abstract In mammals, the functional development of the cochlea requires the tight regulation of multiple molecules and signalling pathways including fibroblast growth factors, bone morphogenetic proteins, Wnt and Notch signalling pathways. Over the last decade, the Eph/ephrin system also emerged as a key player of the development and function of the mammalian cochlea. In this review, we discuss the recent advances on the role of Eph/ephrin signalling in patterning the cochlear sensory epithelium and the complex innervation of mechanosensory hair cells by spiral ganglion neurons. Finally, we address the issue of a syndromic form of hearing loss caused by a deficient member of the Eph/ephrin family. PMID: 30771305 [PubMed - as supplied by publisher] (Source: D...

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Drug Allergy

(Source: eMedicineHealth.com)

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18 F-FDG and 18 F-FAMT PET-derived metabolic parameters predict outcome of oral squamous cell carcinoma

Abstract

Objectives

L-3-[¹⁸F]-Fluoro-α-methyl tyrosine (FAMT), an amino acid positron emission tomography (PET) tracer, complements [¹⁸F]-fluorodeoxyglucose (FDG) in the diagnosis of malignancies. We compared the predictive ability of FAMT PET versus FDG PET regarding metastatic oral squamous cell carcinoma (OSCC) outcomes for distant metastasis, including lymph node metastasis, and identified the relevant metabolic parameters for each.

Methods

We enrolled 160 patients with OSCC who underwent PET/computed tomography using FDG and FAMT before treatment. Outcomes were assessed using clinicopathological characteristics such as the standardized uptake value (SUV_max, SUV_peak), metabolic tumor volume (MTV), and total lesion glycolysis or total lesion retention. Univariate and multivariate Cox proportional hazards models were used to identify the independent predictors of disease-free survival (DFS) and overall survival (OS) during an average follow-up time of 1401.7 and 1646.0 days, respectively. Areas under the receiver operating characteristic curves were analyzed for the accuracy and predictive value of imaging parameters.

Results

Clinical parameters (excluding age) and PET metabolic parameters were significantly associated with OS. Multivariate analysis showed that an infiltrative growth pattern [p = 0.034, hazard ratio (HR) = 2.30], and the FDG-measured SUV_peak (p = 0.045, HR = 2.45) were independent risk factors for DFS and that lymph node metastasis (p = 0.03, HR = 2.57) and the FAMT-measured MTV (p = 0.004, HR = 3.65) were independent risk factors for OS.

Conclusions

In patients with OSCC, FDG PET predicted DFS, whereas FAMT predicted OS. The two PET tracers, combined with clinical parameters, provide complementary, outcome-related diagnostic information in OSCC.

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Hearing interventions to prevent dementia.

Authors: Dawes P Abstract Hearing loss is a marker of risk for cognitive decline and dementia. Controlled hearing intervention studies of long-term cognitive outcomes are challenging, and thus the evidence for the impact of hearing interventions is primarily from observational studies and will likely continue to be from studies other than randomised controlled trials. Seven studies of hearing interventions with cognitive outcomes assessed over longer than 3 years are reviewed. Most were of low-to-moderate quality. One cochlear implant study had indeterminate findings. Of six hearing aid studies, three reported a positive impact of hearing aid use while three reported no impact of hearing aid use on cognitive decline or incident cognitive impairment. Further studies are requir...

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Va0957

Eph/ephrin signalling in the development and function of the mammalian cochlea.

Authors: Defourny J Abstract In mammals, the functional development of the cochlea requires the tight regulation of multiple molecules and signalling pathways including fibroblast growth factors, bone morphogenetic proteins, Wnt and Notch signalling pathways. Over the last decade, the Eph/ephrin system also emerged as a key player of the development and function of the mammalian cochlea. In this review, we discuss the recent advances on the role of Eph/ephrin signalling in patterning the cochlear sensory epithelium and the complex innervation of mechanosensory hair cells by spiral ganglion neurons. Finally, we address the issue of a syndromic form of hearing loss caused by a deficient member of the Eph/ephrin family. PMID: 30771305 [PubMed - as supplied by publisher] (Source: D...

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Drug Allergy

(Source: eMedicineHealth.com)

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E-cig users develop some of the same cancer-related molecular changes as cigarette smokers

Source: EurekAlert! Date: February 14, 2019 If you think vaping is benign, think again. A small USC study shows that e-cig […]

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2DPMrNK

E-cig users develop some of the same cancer-related molecular changes as cigarette smokers

Source: EurekAlert! Date: February 14, 2019 If you think vaping is benign, think again. A small USC study shows that e-cig […]

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2DPMrNK

Drug Allergy

(Source: eMedicineHealth.com)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SVEQ9V

Ultrasound guided continuous Quadratus Lumborum block hastened recovery in patients undergoing open liver resection: a randomized controlled, open-label trial

Abstract

Background

Quadratus lumborum (QL) block is increasingly being used as a new abdominal nerve block technique. In some studies of mid and lower abdominal and hip analgesia, continuous QL block achieved favorable outcomes as an alternative to continuous intravenous analgesia with opioids. However, the use of continuous QL block for upper abdominal pain is less well characterized. This study aimed to investigate the effects of continuous anterior QL block (CQLB) on postoperative pain and recovery in patients undergoing open liver resection.

Methods

Sixty-three patients underwent elective open liver resection were randomly divided into continuous anterior QL block (CQLB, n = 32) group and patient-controlled intravenous analgesia (PCIA, n = 31) group. Patients in CQLB group underwent ultrasound-guided anterior QL block at the second lumbar vertebral transverse processes before general anesthesia, followed by postoperative CQLB analgesia. Patients in PCIA group underwent continuous intravenous analgesia postoperatively. Postoperative numerical rating scale (NRS) pain scores upon coughing and at rest, self-administered analgesic counts, rate of rescue analgesic use, time to first out-of-bed activity and anal flatus after surgery, and incidences of analgesic-related adverse effects were recorded.

Results

Postoperative NRS pain scores on coughing in CQLB group at different time points and NRS pain score at rest 48 h after surgery were significantly lower than those in PCIA group (P < 0.05). Time to first out-of-bed activity and anal flatus after surgery in CQLB group were significantly earlier than those in PCIA group (P < 0.05). No significant differences of postoperative self-administered analgesic counts, rate of postoperative rescue analgesic usage, or incidences of analgesic-related adverse effects were found between the two groups (P > 0.05).

Conclusions

Ultrasound-guided anterior QL block significantly alleviated the pain during coughing after surgery, shortened the time to first out-of-bed activity and anal flatus, promoting postoperative recovery of the patients undergoing open liver resection.

Trial registration

This study has been registered in April 1, 2018 on Chinese Clinical Trail Registry, the registration number is ChiCTR1800015454.

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Why does a point of care guided transfusion algorithm not improve blood loss and transfusion practice in patients undergoing high-risk cardiac surgery? A prospective randomized controlled pilot study

Abstract

Background

Adult cardiac surgery is often complicated by elevated blood losses that account for elevated transfusion requirements. Perioperative bleeding and transfusion of blood products are major risk factors for morbidity and mortality. Timely diagnostic and goal-directed therapies aim at the reduction of bleeding and need for allogeneic transfusions.

Methods

Single-centre, prospective, randomized trial assessing blood loss and transfusion requirements of 26 adult patients undergoing elective cardiac surgery at high risk for perioperative bleeding. Primary endpoint was blood loss at 24 h postoperatively. Random assignment to intra- and postoperative haemostatic management following either an algorithm based on conventional coagulation assays (conventional group: platelet count, aPTT, PT, fibrinogen) or based on point-of-care (PoC-group) monitoring, i.e. activated rotational thromboelastometry (ROTEM®) combined with multiple aggregometry (Multiplate®). Differences between groups were analysed using nonparametric tests for independent samples.

Results

The study was terminated after interim analysis (n = 26). Chest tube drainage volume was 360 ml (IQR 229-599 ml) in the conventional group, and 380 ml (IQR 310-590 ml) in the PoC-group (p = 0.767) after 24 h. Basic patient characteristics, results of PoC coagulation assays, and transfusion requirements of red blood cells and fresh frozen plasma did not differ between groups. Coagulation results were comparable. Platelets were transfused in the PoC group only.

Conclusion

Blood loss via chest tube drainage and transfusion amounts were not different comparing PoC- and central lab-driven transfusion algorithms in subjects that underwent high-risk cardiac surgery. Routine PoC coagulation diagnostics do not seem to be beneficial when actual blood loss is low. High risk procedures might not suffice as a sole risk factor for increased blood loss.

Trial registration

NCT01402739, Date of registration July 26, 2011.

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Drug Allergy

(Source: eMedicineHealth.com)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SVEQ9V

Ultrasound guided continuous Quadratus Lumborum block hastened recovery in patients undergoing open liver resection: a randomized controlled, open-label trial

Abstract

Background

Quadratus lumborum (QL) block is increasingly being used as a new abdominal nerve block technique. In some studies of mid and lower abdominal and hip analgesia, continuous QL block achieved favorable outcomes as an alternative to continuous intravenous analgesia with opioids. However, the use of continuous QL block for upper abdominal pain is less well characterized. This study aimed to investigate the effects of continuous anterior QL block (CQLB) on postoperative pain and recovery in patients undergoing open liver resection.

Methods

Sixty-three patients underwent elective open liver resection were randomly divided into continuous anterior QL block (CQLB, n = 32) group and patient-controlled intravenous analgesia (PCIA, n = 31) group. Patients in CQLB group underwent ultrasound-guided anterior QL block at the second lumbar vertebral transverse processes before general anesthesia, followed by postoperative CQLB analgesia. Patients in PCIA group underwent continuous intravenous analgesia postoperatively. Postoperative numerical rating scale (NRS) pain scores upon coughing and at rest, self-administered analgesic counts, rate of rescue analgesic use, time to first out-of-bed activity and anal flatus after surgery, and incidences of analgesic-related adverse effects were recorded.

Results

Postoperative NRS pain scores on coughing in CQLB group at different time points and NRS pain score at rest 48 h after surgery were significantly lower than those in PCIA group (P < 0.05). Time to first out-of-bed activity and anal flatus after surgery in CQLB group were significantly earlier than those in PCIA group (P < 0.05). No significant differences of postoperative self-administered analgesic counts, rate of postoperative rescue analgesic usage, or incidences of analgesic-related adverse effects were found between the two groups (P > 0.05).

Conclusions

Ultrasound-guided anterior QL block significantly alleviated the pain during coughing after surgery, shortened the time to first out-of-bed activity and anal flatus, promoting postoperative recovery of the patients undergoing open liver resection.

Trial registration

This study has been registered in April 1, 2018 on Chinese Clinical Trail Registry, the registration number is ChiCTR1800015454.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Nb44Md

Why does a point of care guided transfusion algorithm not improve blood loss and transfusion practice in patients undergoing high-risk cardiac surgery? A prospective randomized controlled pilot study

Abstract

Background

Adult cardiac surgery is often complicated by elevated blood losses that account for elevated transfusion requirements. Perioperative bleeding and transfusion of blood products are major risk factors for morbidity and mortality. Timely diagnostic and goal-directed therapies aim at the reduction of bleeding and need for allogeneic transfusions.

Methods

Single-centre, prospective, randomized trial assessing blood loss and transfusion requirements of 26 adult patients undergoing elective cardiac surgery at high risk for perioperative bleeding. Primary endpoint was blood loss at 24 h postoperatively. Random assignment to intra- and postoperative haemostatic management following either an algorithm based on conventional coagulation assays (conventional group: platelet count, aPTT, PT, fibrinogen) or based on point-of-care (PoC-group) monitoring, i.e. activated rotational thromboelastometry (ROTEM®) combined with multiple aggregometry (Multiplate®). Differences between groups were analysed using nonparametric tests for independent samples.

Results

The study was terminated after interim analysis (n = 26). Chest tube drainage volume was 360 ml (IQR 229-599 ml) in the conventional group, and 380 ml (IQR 310-590 ml) in the PoC-group (p = 0.767) after 24 h. Basic patient characteristics, results of PoC coagulation assays, and transfusion requirements of red blood cells and fresh frozen plasma did not differ between groups. Coagulation results were comparable. Platelets were transfused in the PoC group only.

Conclusion

Blood loss via chest tube drainage and transfusion amounts were not different comparing PoC- and central lab-driven transfusion algorithms in subjects that underwent high-risk cardiac surgery. Routine PoC coagulation diagnostics do not seem to be beneficial when actual blood loss is low. High risk procedures might not suffice as a sole risk factor for increased blood loss.

Trial registration

NCT01402739, Date of registration July 26, 2011.

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Sensitivity and specificity of standardised allergen extracts in skin prick test for diagnoses of IgE-mediated respiratory allergies

Skin prick tests (SPTs) are essential for the diagnosis of IgE-mediated allergy and are influenced by extract quality, biological potency and concentration of allergen.

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Sensitivity and specificity of standardised allergen extracts in skin prick test for diagnoses of IgE-mediated respiratory allergies

Skin prick tests (SPTs) are essential for the diagnosis of IgE-mediated allergy and are influenced by extract quality, biological potency and concentration of allergen.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2DQsczf

Experimental Human Infection With Neisseria Gonorrhoeae

Condition:   Gonococcal Infection Interventions:   Drug: Cefixime;   Drug: Ceftriaxone;   Drug: Ciprofloxacin;   Biological: Neisseria gonorrhoeae strain FA1090 A26;   Biological: Neisseria gonorrhoeae strain FA7537 Sponsor:   National Institute of Allergy and Infectious Diseases (NIAID) Recruiting (Source: ClinicalTrials.gov)

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Impact of MEditerranean Diet, Inflammation and Microbiome After an Acute Coronary Syndrome

Condition:   Acute Coronary Syndrome Interventions:   Other: Microbiota analysis;   Other: Immunological analysis;   Other: Proteome analysis;   Other: Metabolome analysis;   Other: Clinical evaluation;   Other: Diet evaluation;   Other: MedDiet Sponsors:   Consorcio Centro de Investigación Biomédica en Red, M.P.;   Hospital General Universitario Gregorio Marañon;   Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana;   University of Navarra;   Institut National de la Santé Et de la Recher che Médicale, France;   Tel Aviv University;   Göteborg University Not yet recruiting (Source: ClinicalTrials.gov)

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Effect of Migalastat on Cardiac Involvement in Fabry Disease

Conditions:   Fabry Disease;   Heart Diseases Intervention:   Diagnostic Test: Cardiological evaluation Sponsors:   Ospedale San Donato;   Amicus Therapeutics;   Institute of Biomedicine and Molecular Immunology - CNR Recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2X8WA0K

Study in Cat-Allergic Patients With Asthma to Evaluate the Efficacy of a Single Dose of REGN1908-1909 to Reduce Bronchoconstriction Upon Cat Allergen Challenge

Conditions:   Cat Allergy;   Mild Asthma Interventions:   Drug: REGN1908-1909;   Drug: Placebo Sponsor:   Regeneron Pharmaceuticals Not yet recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SbScdw

Combining TLR9 Agonist With bNAbs for Reservoir Reduction and Immunological Control of HIV

Condition:   HIV-1-infection Interventions:   Drug: Saline;   Drug: Lefitolimod;   Drug: 3BNC117 and 10-1074 Sponsors:   University of Aarhus;   Aalborg Universitetshospital;   Odense University Hospital;   Rigshospitalet, Denmark;   Hvidovre University Hospital;   The Peter Doherty Institute for Infection and Immunity;   University of Utah Not yet recruiting (Source: ClinicalTrials.gov)

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The Influence of ANS-6637 on Midazolam Pharmacokinetics in Healthy Volunteers

Condition:   Opioid Addiction Interventions:   Drug: MDZ;   Drug: ANS-6637 Sponsors:   National Institutes of Health Clinical Center (CC);   National Institute of Allergy and Infectious Diseases (NIAID) Recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SaOHUB

Experimental Human Infection With Neisseria Gonorrhoeae

Condition:   Gonococcal Infection Interventions:   Drug: Cefixime;   Drug: Ceftriaxone;   Drug: Ciprofloxacin;   Biological: Neisseria gonorrhoeae strain FA1090 A26;   Biological: Neisseria gonorrhoeae strain FA7537 Sponsor:   National Institute of Allergy and Infectious Diseases (NIAID) Recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2X8Wy98

Impact of MEditerranean Diet, Inflammation and Microbiome After an Acute Coronary Syndrome

Condition:   Acute Coronary Syndrome Interventions:   Other: Microbiota analysis;   Other: Immunological analysis;   Other: Proteome analysis;   Other: Metabolome analysis;   Other: Clinical evaluation;   Other: Diet evaluation;   Other: MedDiet Sponsors:   Consorcio Centro de Investigación Biomédica en Red, M.P.;   Hospital General Universitario Gregorio Marañon;   Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana;   University of Navarra;   Institut National de la Santé Et de la Recher che Médicale, France;   Tel Aviv University;   Göteborg University Not yet recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2S74jso

Effect of Migalastat on Cardiac Involvement in Fabry Disease

Conditions:   Fabry Disease;   Heart Diseases Intervention:   Diagnostic Test: Cardiological evaluation Sponsors:   Ospedale San Donato;   Amicus Therapeutics;   Institute of Biomedicine and Molecular Immunology - CNR Recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2X8WA0K

Study in Cat-Allergic Patients With Asthma to Evaluate the Efficacy of a Single Dose of REGN1908-1909 to Reduce Bronchoconstriction Upon Cat Allergen Challenge

Conditions:   Cat Allergy;   Mild Asthma Interventions:   Drug: REGN1908-1909;   Drug: Placebo Sponsor:   Regeneron Pharmaceuticals Not yet recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SbScdw

Combining TLR9 Agonist With bNAbs for Reservoir Reduction and Immunological Control of HIV

Condition:   HIV-1-infection Interventions:   Drug: Saline;   Drug: Lefitolimod;   Drug: 3BNC117 and 10-1074 Sponsors:   University of Aarhus;   Aalborg Universitetshospital;   Odense University Hospital;   Rigshospitalet, Denmark;   Hvidovre University Hospital;   The Peter Doherty Institute for Infection and Immunity;   University of Utah Not yet recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2X6vcjU

The Influence of ANS-6637 on Midazolam Pharmacokinetics in Healthy Volunteers

Condition:   Opioid Addiction Interventions:   Drug: MDZ;   Drug: ANS-6637 Sponsors:   National Institutes of Health Clinical Center (CC);   National Institute of Allergy and Infectious Diseases (NIAID) Recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SaOHUB

E-cig users develop some of the same cancer-related molecular changes as cigarette smokers

Source: EurekAlert! Date: February 14, 2019 If you think vaping is benign, think again. A small USC study shows that e-cig […]

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2DPMrNK

E-cig users develop some of the same cancer-related molecular changes as cigarette smokers

Source: EurekAlert! Date: February 14, 2019 If you think vaping is benign, think again. A small USC study shows that e-cig […]

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2DPMrNK

Gene expression profiling of Jagged1 treated human periodontal ligament cells

Abstract

Objective

Jagged1 regulates several biological functions in human periodontal ligament cells (hPDLs). The present study aimed to evaluate mRNA expression profiling of Jagged1 treated hPDLs using microarray technique.

Methods

Notch ligands, Jagged1, were indirectly immobilized on tissue culture surface. Subsequently, hPDLs were seeded on Jagged1 immobilized surface and maintained in growth medium for 48 h. Total RNA was collected and processed. Gene expression profiling was examined using microarray technique. Real‐time polymerase chain reaction and immunofluorescence staining was employed to determine mRNA and protein expression levels, respectively. Cell proliferation and colony forming unit assay were performed. Cell cycle was evaluated using propidium iodide staining and flow cytometry analysis.

Results

The isolated cells demonstrated fibroblast‐like morphology and exhibited the co‐expression of CD44, CD90, and CD105 surface markers. After stimulated with Jagged1, the total of 411 genes were differentially expressed, consisting both coding and non‐coding genes. For coding genes, 165 and 160 coding genes were upregulated and downregulated, respectively. Pathway analysis revealed that the upregulated genes were mainly involved in cellular interactions, signal transduction, and collagen formation and degradation while the downregulated genes were in the events and phases in cell cycle. Jagged1 significantly decreased cell proliferation, reduced colony forming unit ability and induced G0/G1 cell cycle arrest in hPDLs.

Conclusion

Jagged1 regulates various biological pathway in hPDLs. This gene expression profiling could help to understand the mechanisms potentially involved in the Notch signaling regulation in periodontal homeostasis.

This article is protected by copyright. All rights reserved.

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Necrotizing sialometaplasia can hide the presence of salivary gland tumors. A case series

Abstract

Objective

Necrotizing sialometaplasia (NS) is an uncommon benign process which affects minor and, more rarely, major salivary glands. While self‐limiting, the condition might be clinically and histologically mistaken for malignancy. Furthermore, NS may accompany neoplasms. The aim of this paper is to report a series of Italian patients affected by NS associated with an unusual high presence of neoplasms of minor and major salivary glands.

Study Design

Clinical and histological features of twelve patients with NS were retrospectively evaluated.

Results

Eight patients presented NS of the minor salivary glands of the palate, two of them had associated neoplasms (pleomorphic adenoma and adenoid cystic carcinoma) at the same site. Four patients had NS of the parotid gland associated with a history of fine needle aspiration biopsy performed to diagnose parotid neoplasms. These were epithelial‐myoepithelial carcinoma, adenoid cystic carcinoma, Warthin's tumor and oncocytoma, respectively.

Conclusion

Tumors of minor and major salivary glands might be associated with NS more frequently than previously reported. While NS of the parotid is generally the result of invasive diagnostic procedure and is detected after the excision of the tumor, NS of the minor salivary glands may obscure an underlying neoplasm, resulting in delays in referral or treatment.

This article is protected by copyright. All rights reserved.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2TXw4Fy

Gene expression profiling of Jagged1 treated human periodontal ligament cells

Abstract

Objective

Jagged1 regulates several biological functions in human periodontal ligament cells (hPDLs). The present study aimed to evaluate mRNA expression profiling of Jagged1 treated hPDLs using microarray technique.

Methods

Notch ligands, Jagged1, were indirectly immobilized on tissue culture surface. Subsequently, hPDLs were seeded on Jagged1 immobilized surface and maintained in growth medium for 48 h. Total RNA was collected and processed. Gene expression profiling was examined using microarray technique. Real‐time polymerase chain reaction and immunofluorescence staining was employed to determine mRNA and protein expression levels, respectively. Cell proliferation and colony forming unit assay were performed. Cell cycle was evaluated using propidium iodide staining and flow cytometry analysis.

Results

The isolated cells demonstrated fibroblast‐like morphology and exhibited the co‐expression of CD44, CD90, and CD105 surface markers. After stimulated with Jagged1, the total of 411 genes were differentially expressed, consisting both coding and non‐coding genes. For coding genes, 165 and 160 coding genes were upregulated and downregulated, respectively. Pathway analysis revealed that the upregulated genes were mainly involved in cellular interactions, signal transduction, and collagen formation and degradation while the downregulated genes were in the events and phases in cell cycle. Jagged1 significantly decreased cell proliferation, reduced colony forming unit ability and induced G0/G1 cell cycle arrest in hPDLs.

Conclusion

Jagged1 regulates various biological pathway in hPDLs. This gene expression profiling could help to understand the mechanisms potentially involved in the Notch signaling regulation in periodontal homeostasis.

This article is protected by copyright. All rights reserved.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2BGERo5

Necrotizing sialometaplasia can hide the presence of salivary gland tumors. A case series

Abstract

Objective

Necrotizing sialometaplasia (NS) is an uncommon benign process which affects minor and, more rarely, major salivary glands. While self‐limiting, the condition might be clinically and histologically mistaken for malignancy. Furthermore, NS may accompany neoplasms. The aim of this paper is to report a series of Italian patients affected by NS associated with an unusual high presence of neoplasms of minor and major salivary glands.

Study Design

Clinical and histological features of twelve patients with NS were retrospectively evaluated.

Results

Eight patients presented NS of the minor salivary glands of the palate, two of them had associated neoplasms (pleomorphic adenoma and adenoid cystic carcinoma) at the same site. Four patients had NS of the parotid gland associated with a history of fine needle aspiration biopsy performed to diagnose parotid neoplasms. These were epithelial‐myoepithelial carcinoma, adenoid cystic carcinoma, Warthin's tumor and oncocytoma, respectively.

Conclusion

Tumors of minor and major salivary glands might be associated with NS more frequently than previously reported. While NS of the parotid is generally the result of invasive diagnostic procedure and is detected after the excision of the tumor, NS of the minor salivary glands may obscure an underlying neoplasm, resulting in delays in referral or treatment.

This article is protected by copyright. All rights reserved.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2TXw4Fy

Comparison of Er,Cr:YSGG and diode laser effects on dentin hypersensitivity: a split-mouth randomized clinical trial

Abstract

Objectives

The aim of the present study was to compare the clinical efficacy of diode laser and Er,Cr:YSGG lasers in the treatment of dentin hypersensitivity.

Materials and methods

Thirty-four teeth from 17 patients with dentin hypersensitivity were divided into two groups. In group D, the teeth were irradiated with diode laser beams with a wavelength of 940 nm for 1 min, and in group E, the teeth were irradiated with Er,Cr:YSGG laser beams with a wavelength of 2780 nm and a pulse width of 140–200 μs. Treatments with laser beams were carried out in 1 session. Sensitivity was assessed with air spray and a dental explorer. Pain severity was measured with the use of visual analog scale (VAS) before and after laser application.

Results

A decrease in dentin hypersensitivity was observed in both groups immediately, 1 week, and 1 month after laser irradiation. Statistically significant differences were found between the two groups in dentin hypersensitivity severity only 1 month after laser application. The decrease in dentin hypersensitivity by Er,Cr:YSGG laser was significantly higher than that by diode laser at this time interval.

Conclusion

The decrease in dentin hypersensitivity after application of Er,Cr:YSGG laser was significantly higher than that after the application of diode laser at 1-month postoperative interval.

Clinical relevance

Er,Cr:YSGG laser is a better choice than diode laser for the treatment of dentin hypersensitivity in the short term.

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Impact of the radiographic method on treatment decisions related to dental caries in primary molars: a before–after study

Abstract

Objectives

To evaluate the impact of radiographic examination on changes of treatment decision related to dental caries compared to decisions guided by visual inspection alone in primary molars.

Materials and methods

A total of 126 children aged 3–6 years who had sought dental assistance were randomly selected and examined by two calibrated examiners using visual inspection. A treatment plan regarding dental caries was generated based on this assessment. The same examiners then evaluated two bitewing radiographs, creating an additional treatment plan guided by concurrent assessment of both visual and radiographic methods. Occlusal and proximal surfaces of primary molars received a treatment decision as follows: (i) no treatment, (ii) non-operative treatment, and (iii) operative treatment. The frequency of changes in the treatment decision after radiographic examination was calculated, with subsequent Poisson multilevel regression analysis to evaluate variables influencing such changes.

Results

Changes from "no treatment" decided with visual inspection to "non-operative treatment" after radiographic evaluation occurred in 52 surfaces (3.2%), and changes to "operative treatment" were observed in 46 dental surfaces (2.8%). Furthermore, 50 surfaces (6.2%) had their treatment decision changed from non-operative to operative treatment after radiographic assessment. In addition, changes were significantly more frequent in children with higher caries experience, on proximal surfaces and in 1st primary molars.

Conclusions

The impact of radiographic examination on changes in the treatment decision of primary molars made with visual inspection is modest. Changes are more frequent in children with higher caries experience and in proximal surfaces.

Clinical relevance

The benefits of the radiographic method for detecting caries in children, as a protocol in the diagnostic process, seem to be overestimated; the impact of this method on changes in treatment decision made by visual examination alone is low. Radiographs could be, however, useful in particular conditions, such as in children with high caries experience.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2DU4x0L

Quantitative Imaging of Alpha-Emitting Therapeutic Radiopharmaceuticals

Abstract

Targeted alpha therapy (TAT) is an active area of drug development as a highly specific and highly potent therapeutic modality that can be applied to many types of late-stage cancers. In order to properly evaluate its safety and efficacy, understanding biokinetics of alpha-emitting radiopharmaceuticals is essential. Quantitative imaging of alpha-emitting radiopharmaceuticals is often possible via imaging of gammas and positrons produced during complex decay chains of these radionuclides. Analysis of the complex decay chains for alpha-emitting radionuclides (Tb-149, At-211, Bi-212 (decayed from Pb-212), Bi-213, Ra-223, Ac-225, and Th-227) with relevance to imageable signals is attempted in this mini-review article. Gamma camera imaging, single-photon emission computed tomography, positron emission tomography, bremsstrahlung radiation imaging, Cerenkov luminescence imaging, and Compton cameras are briefly discussed as modalities for imaging alpha-emitting radiopharmaceuticals.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2GQTj07

Comparison of Er,Cr:YSGG and diode laser effects on dentin hypersensitivity: a split-mouth randomized clinical trial

Abstract

Objectives

The aim of the present study was to compare the clinical efficacy of diode laser and Er,Cr:YSGG lasers in the treatment of dentin hypersensitivity.

Materials and methods

Thirty-four teeth from 17 patients with dentin hypersensitivity were divided into two groups. In group D, the teeth were irradiated with diode laser beams with a wavelength of 940 nm for 1 min, and in group E, the teeth were irradiated with Er,Cr:YSGG laser beams with a wavelength of 2780 nm and a pulse width of 140–200 μs. Treatments with laser beams were carried out in 1 session. Sensitivity was assessed with air spray and a dental explorer. Pain severity was measured with the use of visual analog scale (VAS) before and after laser application.

Results

A decrease in dentin hypersensitivity was observed in both groups immediately, 1 week, and 1 month after laser irradiation. Statistically significant differences were found between the two groups in dentin hypersensitivity severity only 1 month after laser application. The decrease in dentin hypersensitivity by Er,Cr:YSGG laser was significantly higher than that by diode laser at this time interval.

Conclusion

The decrease in dentin hypersensitivity after application of Er,Cr:YSGG laser was significantly higher than that after the application of diode laser at 1-month postoperative interval.

Clinical relevance

Er,Cr:YSGG laser is a better choice than diode laser for the treatment of dentin hypersensitivity in the short term.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SGjU7i

Impact of the radiographic method on treatment decisions related to dental caries in primary molars: a before–after study

Abstract

Objectives

To evaluate the impact of radiographic examination on changes of treatment decision related to dental caries compared to decisions guided by visual inspection alone in primary molars.

Materials and methods

A total of 126 children aged 3–6 years who had sought dental assistance were randomly selected and examined by two calibrated examiners using visual inspection. A treatment plan regarding dental caries was generated based on this assessment. The same examiners then evaluated two bitewing radiographs, creating an additional treatment plan guided by concurrent assessment of both visual and radiographic methods. Occlusal and proximal surfaces of primary molars received a treatment decision as follows: (i) no treatment, (ii) non-operative treatment, and (iii) operative treatment. The frequency of changes in the treatment decision after radiographic examination was calculated, with subsequent Poisson multilevel regression analysis to evaluate variables influencing such changes.

Results

Changes from "no treatment" decided with visual inspection to "non-operative treatment" after radiographic evaluation occurred in 52 surfaces (3.2%), and changes to "operative treatment" were observed in 46 dental surfaces (2.8%). Furthermore, 50 surfaces (6.2%) had their treatment decision changed from non-operative to operative treatment after radiographic assessment. In addition, changes were significantly more frequent in children with higher caries experience, on proximal surfaces and in 1st primary molars.

Conclusions

The impact of radiographic examination on changes in the treatment decision of primary molars made with visual inspection is modest. Changes are more frequent in children with higher caries experience and in proximal surfaces.

Clinical relevance

The benefits of the radiographic method for detecting caries in children, as a protocol in the diagnostic process, seem to be overestimated; the impact of this method on changes in treatment decision made by visual examination alone is low. Radiographs could be, however, useful in particular conditions, such as in children with high caries experience.

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Quantitative Imaging of Alpha-Emitting Therapeutic Radiopharmaceuticals

Abstract

Targeted alpha therapy (TAT) is an active area of drug development as a highly specific and highly potent therapeutic modality that can be applied to many types of late-stage cancers. In order to properly evaluate its safety and efficacy, understanding biokinetics of alpha-emitting radiopharmaceuticals is essential. Quantitative imaging of alpha-emitting radiopharmaceuticals is often possible via imaging of gammas and positrons produced during complex decay chains of these radionuclides. Analysis of the complex decay chains for alpha-emitting radionuclides (Tb-149, At-211, Bi-212 (decayed from Pb-212), Bi-213, Ra-223, Ac-225, and Th-227) with relevance to imageable signals is attempted in this mini-review article. Gamma camera imaging, single-photon emission computed tomography, positron emission tomography, bremsstrahlung radiation imaging, Cerenkov luminescence imaging, and Compton cameras are briefly discussed as modalities for imaging alpha-emitting radiopharmaceuticals.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2GQTj07

Brain Stem and Audio-Vestibular Regulation

Abstract

The central pathologies present with perverted auditory perception and compromised postural control. Considering the existing controversy this study involves assessments of 100 cases of post fossa tumefactions in which a detailed clinical and neuro-otological (pure tone audiometry, electronystagmography, brainstem evoked response audiometry) profile is compared with their imaging patterns. The CP angle schwannomas (N = 26) presented with abnormal speech tests (N = 18), abnormal auditory adaptation (N = 7) and ABR with pathologically increased latency of wave V (N = 32), poor formation of wave I (N = 31) along with abnormal inter-wave interval (N = 32). In lesions (N = 32) compressing deeper nuclei, vermis and axial parts of brain stem, a gross truncal ataxia, incoordination, nystagmus, speech defects, subtotal deafness and bilateral ABR abnormalities were observed. The abnormal optomotor activities were seen as saccadic (N = 44) and deformed slow pursuit eye movements (N = 20). Inability to sustain holding function resulted in gaze nystagmus (N = 71), and poor timing manifested as fixation overshoots (N = 42). The midline cerebellar and upper brain stem lesions revealed bilateral OKN abnormalities whereas paramedian pathology showed only ipsilateral distortion. Caloric tests revealed culmination frequency as the most sensitive parameter for assessment of the hypo-reflexia in diffuse cerebellopathies while slow phase velocity in cases of posterior fossa lesion. The caloric hypo-activity appears to be of a better localizing value than the directional preponderance. The slow pursuit tracking revealed Type III curve perhaps due to defective regulation of slow movements in partially intact cerebellum (N = 15), while gross cerebellar dysfunctioning resulted into Type IV curve (N = 5).

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2TVYOhV