Topical steroid vs placebo for the prevention of radiation dermatitis in head and neck cancer patients receiving ...

Topical steroid vs placebo for the prevention of radiation dermatitis in head and neck cancer patients receiving ...  MD LinxFull coverage

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Topical steroid vs placebo for the prevention of radiation dermatitis in head and neck cancer patients receiving ...

Topical steroid vs placebo for the prevention of radiation dermatitis in head and neck cancer patients receiving ...  MD LinxFull coverage

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COMISS Score for Detection of Cow's Milk Protein Allergy in Children With Recrrent or Persistent Gastrointestinal Manifistations in Infants Attending Assuit University Children Hospital - Egypt

Condition:   Cow Milk Allergy Intervention:   Diagnostic Test: COMISS score Sponsor:   caroline maher Not yet recruiting (Source: ClinicalTrials.gov)

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Liver Transplantation With Tregs at UCSF

Condition:   Liver Transplant Interventions:   Biological: arTreg;   Procedure: leukapheresis;   Drug: cyclophosphamide;   Drug: mesna;   Drug: everolimus Sponsors:   National Institute of Allergy and Infectious Diseases (NIAID);   Immune Tolerance Network (ITN) Not yet recruiting (Source: ClinicalTrials.gov)

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HIV Infection and Risk Related Coinfections/Comorbidities in Indonesia

Condition:   HIV Intervention:   Sponsors:   Ina-Respond;   National Institute of Allergy and Infectious Diseases (NIAID) Recruiting (Source: ClinicalTrials.gov)

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HIV Infection and Risk Related Coinfections/Comorbidities in Indonesia

Condition:   HIV Intervention:   Sponsors:   Ina-Respond;   National Institute of Allergy and Infectious Diseases (NIAID) Recruiting (Source: ClinicalTrials.gov)

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COMISS Score for Detection of Cow's Milk Protein Allergy in Children With Recrrent or Persistent Gastrointestinal Manifistations in Infants Attending Assuit University Children Hospital - Egypt

Condition:   Cow Milk Allergy Intervention:   Diagnostic Test: COMISS score Sponsor:   caroline maher Not yet recruiting (Source: ClinicalTrials.gov)

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Growth of Infants With Cow's Milk Allergy Fed an Amino Acid-based Formula Containing Two Human Milk Oligosaccharides

Condition:   Cow Milk Allergy Intervention:   Other: Food for Specific Medical Purpose Sponsor:   Nestlé Not yet recruiting (Source: ClinicalTrials.gov)

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A Methodology Development Environmental Clinical Trial of Reproxalap in Subjects With Seasonal Allergic Conjunctivitis

Condition:   Allergic Conjunctivitis Interventions:   Drug: Reproxalap Ophthalmic Solution (0.25%);   Drug: Reproxalap Ophthalmic Solution (0.5%);   Drug: Vehicle Ophthalmic Solution Sponsor:   Aldeyra Therapeutics, Inc. Not yet recruiting (Source: ClinicalTrials.gov)

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A Methodology Development Environmental Clinical Trial of Reproxalap in Subjects With Seasonal Allergic Conjunctivitis

Condition:   Allergic Conjunctivitis Interventions:   Drug: Reproxalap Ophthalmic Solution (0.25%);   Drug: Reproxalap Ophthalmic Solution (0.5%);   Drug: Vehicle Ophthalmic Solution Sponsor:   Aldeyra Therapeutics, Inc. Not yet recruiting (Source: ClinicalTrials.gov)

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Liver Transplantation With Tregs at UCSF

Condition:   Liver Transplant Interventions:   Biological: arTreg;   Procedure: leukapheresis;   Drug: cyclophosphamide;   Drug: mesna;   Drug: everolimus Sponsors:   National Institute of Allergy and Infectious Diseases (NIAID);   Immune Tolerance Network (ITN) Not yet recruiting (Source: ClinicalTrials.gov)

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Mite Asthma Pediatric Immunotherapy Trial

Conditions:   Allergic Asthma Due to Dermatophagoides Farinae;   Allergic Asthma Due to Dermatophagoides Pteronyssinus;   Allergic Rhinitis Due to House Dust Mite Interventions:   Biological: HDM SLIT-tablet;   Other: Placebo Sponsor:   ALK-Abelló A/S Recruiting (Source: ClinicalTrials.gov)

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Mite Asthma Pediatric Immunotherapy Trial

Conditions:   Allergic Asthma Due to Dermatophagoides Farinae;   Allergic Asthma Due to Dermatophagoides Pteronyssinus;   Allergic Rhinitis Due to House Dust Mite Interventions:   Biological: HDM SLIT-tablet;   Other: Placebo Sponsor:   ALK-Abelló A/S Recruiting (Source: ClinicalTrials.gov)

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Immune Response and Risk of Side Effects After Influenza Vaccination in Athletes

Conditions:   Influenza Virus Vaccine Adverse Reaction;   Influenza Vaccine Allergy Intervention:   Biological: Influenza Vaccination Sponsors:   Saarland University;   German Federal Institute of Sport Science Completed (Source: ClinicalTrials.gov)

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Immune Response and Risk of Side Effects After Influenza Vaccination in Athletes

Conditions:   Influenza Virus Vaccine Adverse Reaction;   Influenza Vaccine Allergy Intervention:   Biological: Influenza Vaccination Sponsors:   Saarland University;   German Federal Institute of Sport Science Completed (Source: ClinicalTrials.gov)

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To Evaluate the Efficacy and Safety of HL151 Versus Placebo in Perennial Allergic Rhinitis Patients

Condition:   Perennial Allergic Rhinitis Interventions:   Drug: HL151;   Drug: placebo Sponsor:   Hanlim Pharm. Co., Ltd. Completed (Source: ClinicalTrials.gov)

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To Evaluate the Efficacy and Safety of HL151 Versus Placebo in Perennial Allergic Rhinitis Patients

Condition:   Perennial Allergic Rhinitis Interventions:   Drug: HL151;   Drug: placebo Sponsor:   Hanlim Pharm. Co., Ltd. Completed (Source: ClinicalTrials.gov)

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Ternary semiconductor ZnxAg1-xS nanocomposites for efficient photocatalytic degradation of organophosphorus pesticides †

Photochem. Photobiol. Sci., 2018, Accepted Manuscript
DOI: 10.1039/C8PP00220G, Paper

Ayodhya Dasari, Veerabhadram Guttena
Construction of ternary semiconductor nanostructures has attracted much attention in photocatalysis by virtue of the tunable elemental composition and band structure. Herein, ternary semiconductor ZnxAg1-xS (0 ≤ x ≤ 1)...
The content of this RSS Feed (c) The Royal Society of Chemistry

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Automated on-line monitoring of the TiO2 based photocatalytic degradation of dimethyl phthalate and diethyl phthalate

Photochem. Photobiol. Sci., 2018, Accepted Manuscript
DOI: 10.1039/C8PP00307F, Paper

Daniel Salazar-Beltrán, Laura Hinojosa-Reyes, Fernando Maya, Gemma Turnes Palomino, Carlos Palomino Cabello, Aracely Hernandez-Ramirez, Jorge Luis Guzmán-Mar
A fully automated on-line system for monitoring the TiO₂ based photocatalytic degradation of dimethyl phthalate (DMP) and diethyl phthalate (DEP) using sequential injection analysis (SIA) coupled to liquid chromatography (LC)...
The content of this RSS Feed (c) The Royal Society of Chemistry

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Ternary semiconductor ZnxAg1-xS nanocomposites for efficient photocatalytic degradation of organophosphorus pesticides †

Photochem. Photobiol. Sci., 2018, Accepted Manuscript
DOI: 10.1039/C8PP00220G, Paper

Ayodhya Dasari, Veerabhadram Guttena
Construction of ternary semiconductor nanostructures has attracted much attention in photocatalysis by virtue of the tunable elemental composition and band structure. Herein, ternary semiconductor ZnxAg1-xS (0 ≤ x ≤ 1)...
The content of this RSS Feed (c) The Royal Society of Chemistry

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Automated on-line monitoring of the TiO2 based photocatalytic degradation of dimethyl phthalate and diethyl phthalate

Photochem. Photobiol. Sci., 2018, Accepted Manuscript
DOI: 10.1039/C8PP00307F, Paper

Daniel Salazar-Beltrán, Laura Hinojosa-Reyes, Fernando Maya, Gemma Turnes Palomino, Carlos Palomino Cabello, Aracely Hernandez-Ramirez, Jorge Luis Guzmán-Mar
A fully automated on-line system for monitoring the TiO₂ based photocatalytic degradation of dimethyl phthalate (DMP) and diethyl phthalate (DEP) using sequential injection analysis (SIA) coupled to liquid chromatography (LC)...
The content of this RSS Feed (c) The Royal Society of Chemistry

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Uncemented, curved, short endoprosthesis stem for distal femoral reconstruction: early follow-up outcomes

Uncemented endoprosthetic knee replacement has become a mainstream treatment for malignant tumours of the distal femur. Most femoral stems, however, are straight and therefore poorly fit the anteriorly bowed c...

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Assessment of thyroid cancer risk in more than 334,000 patients with inflammatory bowel disease: a case-control study and a meta-analysis

Potential risk of thyroid cancer in patients with inflammatory bowel disease has not been well investigated. The aim of the study was to reveal the relationship between history of inflammatory bowel disease an...

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Uncemented, curved, short endoprosthesis stem for distal femoral reconstruction: early follow-up outcomes

Uncemented endoprosthetic knee replacement has become a mainstream treatment for malignant tumours of the distal femur. Most femoral stems, however, are straight and therefore poorly fit the anteriorly bowed c...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2x0IK5a

Assessment of thyroid cancer risk in more than 334,000 patients with inflammatory bowel disease: a case-control study and a meta-analysis

Potential risk of thyroid cancer in patients with inflammatory bowel disease has not been well investigated. The aim of the study was to reveal the relationship between history of inflammatory bowel disease an...

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Papillary Thyroid Cancer Pipeline Therapeutics Assessment, 2018

Papillary Thyroid Cancer Pipeline Therapeutics Assessment, 2018  indsutryjournal.comFull coverage

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Papillary Thyroid Cancer Pipeline Therapeutics Assessment, 2018

Papillary Thyroid Cancer Pipeline Therapeutics Assessment, 2018  indsutryjournal.comFull coverage

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For new cancer treatments, less is more

For new cancer treatments, less is more  Chicago TribuneFull coverage

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This Is How Much Chemo A Person Needs In The Early Stages Of Cancer

This Is How Much Chemo A Person Needs In The Early Stages Of Cancer  NDTVFull coverage

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For new cancer treatments, less is more

For new cancer treatments, less is more  Chicago TribuneFull coverage

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Current Utilization of Biologicals

FACIAL PLASTIC SURGERY CLINICS OF NORTH AMERICA

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Copyright

ELSEVIER

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Copyright

ELSEVIER

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Forthcoming Issues

Skin Cancer Surgery

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Forthcoming Issues

Skin Cancer Surgery

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Contributors

J. REGAN THOMAS, MD

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Contents

Gregory S. Keller

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Contents

Gregory S. Keller

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Current Utilization of Biologicals

FACIAL PLASTIC SURGERY CLINICS OF NORTH AMERICA

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2x2F3v0

Copyright

ELSEVIER

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Forthcoming Issues

Skin Cancer Surgery

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Contributors

J. REGAN THOMAS, MD

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LORATADINE ALLERGY RELIEF (Loratadine) Tablet [Bryant Ranch Prepack]

Updated Date: Sep 10, 2018 EST (Source: DailyMed Drug Label Updates)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

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Contents

Gregory S. Keller

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Contributors

J. REGAN THOMAS, MD

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2NyxXIM

Contents

Gregory S. Keller

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LORATADINE ALLERGY RELIEF (Loratadine) Tablet [Bryant Ranch Prepack]

Updated Date: Sep 10, 2018 EST (Source: DailyMed Drug Label Updates)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

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ALLERGY RELIEF-D (Cetirizine Hydrochloride And Pseudoephedrine Hydrochloride) Tablet, Film Coated, Extended Release [Ohm Laboratories Inc.]

Updated Date: Sep 10, 2018 EST (Source: DailyMed Drug Label Updates)

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ALLERGY RELIEF-D (Cetirizine Hydrochloride And Pseudoephedrine Hydrochloride) Tablet, Film Coated, Extended Release [Ohm Laboratories Inc.]

Updated Date: Sep 10, 2018 EST (Source: DailyMed Drug Label Updates)

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Laryngectomy patients call on Queensland Government to cough up funds for device

Laryngectomy patients call on Queensland Government to cough up funds for device  ABC NewsFull coverage

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Laryngectomy patients call on Queensland Government to cough up funds for device

Laryngectomy patients call on Queensland Government to cough up funds for device  ABC NewsFull coverage

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Artemisia pollen (mugwort) as a major vector for ambient LPS: brothers in harm?

(Source: Journal of Allergy and Clinical Immunology)

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Artemisia pollen (mugwort) as a major vector for ambient LPS: brothers in harm?

(Source: Journal of Allergy and Clinical Immunology)

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Rhinitis in Children and Adolescents with Asthma: Ubiquitous, Difficult to Control, and Associated with Asthma Outcomes

Almost all children and adolescents with asthma have rhinitis of various, stable phenotypes based on sensitization and seasonal pattern. Conventional medications control rhinitis symptoms only in a minority. Difficult-to-control asthma is associated with worse rhinitis. (Source: Journal of Allergy and Clinical Immunology)

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Rhinitis in Children and Adolescents with Asthma: Ubiquitous, Difficult to Control, and Associated with Asthma Outcomes

Almost all children and adolescents with asthma have rhinitis of various, stable phenotypes based on sensitization and seasonal pattern. Conventional medications control rhinitis symptoms only in a minority. Difficult-to-control asthma is associated with worse rhinitis. (Source: Journal of Allergy and Clinical Immunology)

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Cesarean delivery, preterm birth, and risk of food allergy: Nationwide Swedish cohort study of more than 1 million children

Little is known about early-life risk factors for food allergy in children. (Source: Journal of Allergy and Clinical Immunology)

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Cesarean delivery, preterm birth, and risk of food allergy: Nationwide Swedish cohort study of more than 1 million children

Little is known about early-life risk factors for food allergy in children. (Source: Journal of Allergy and Clinical Immunology)

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Advances in asthma in 2017: Mechanism, biologics, and genetics

This review summarizes some of the most significant advances in asthma research over the past year. We first focus on novel discoveries in the mechanism of asthma development and exacerbation. This is followed by a discussion of potential new biomarkers, including the use of radiographic markers of disease. Several new biologics have become available to the clinician in the past year, and we summarize these advances and how they may influence the clinical delivery of asthma care. Following this, important findings in the genetics of asthma and heterogeneity in phenotypes of the disease are explored, as is the role the environment plays in shaping the development and exacerbation of asthma. (Source: Journal of Allergy and Clinical Immunology)

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Advances in asthma in 2017: Mechanism, biologics, and genetics

This review summarizes some of the most significant advances in asthma research over the past year. We first focus on novel discoveries in the mechanism of asthma development and exacerbation. This is followed by a discussion of potential new biomarkers, including the use of radiographic markers of disease. Several new biologics have become available to the clinician in the past year, and we summarize these advances and how they may influence the clinical delivery of asthma care. Following this, important findings in the genetics of asthma and heterogeneity in phenotypes of the disease are explored, as is the role the environment plays in shaping the development and exacerbation of asthma. (Source: Journal of Allergy and Clinical Immunology)

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How to Treat Hypothyroidism

How to Treat Hypothyroidism  RedOrbitFull coverage

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How to Treat Hypothyroidism

How to Treat Hypothyroidism  RedOrbitFull coverage

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Allergy diagnosis from symptoms to molecules, or from molecules to symptoms: a comparative clinical study

ConclusionsFor the diagnostic verification of clinically suspected allergy, the novel concept "from molecules to clinic" offers a reliable diagnostic workup in shorter time. Due to lower skin test numbers it is especially applicable for young children and seniors, in atopic patients, and whenever skin tests get difficult or unreliable. (Source: World Allergy Organization Journal)

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Comparing Asthma Control Questionnaire (ACQ) and National Asthma Education and Prevention Program (NAEPP) Asthma Control Criteria

Adequate assessment of control is critical to asthma management. The Asthma Control Questionnaire (ACQ) and the National Asthma Education and Prevention Program (NAEPP) criteria are commonly used measures of asthma control. (Source: Annals of Allergy, Asthma and Immunology)

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Microglia priming by interleukin-6 signaling is enhanced in aged mice

This study examined the functional role of IL-6 signaling on microglia priming. Our hypothesis is that IL-6 signaling mediates primed states of microglia in the aged. An initial study assessed age-related alteration in IL-6 signaling molecules; sIL-6R and sgp130 were measured in cerebrospinal fluid of young and aged wild-type animals. (Source: Journal of Neuroimmunology)

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Rhinitis in Children and Adolescents with Asthma: Ubiquitous, Difficult to Control, and Associated with Asthma Outcomes

Almost all children and adolescents with asthma have rhinitis of various, stable phenotypes based on sensitization and seasonal pattern. Conventional medications control rhinitis symptoms only in a minority. Difficult-to-control asthma is associated with worse rhinitis. (Source: Journal of Allergy and Clinical Immunology)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

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Artemisia pollen (mugwort) as a major vector for ambient LPS: brothers in harm?

(Source: Journal of Allergy and Clinical Immunology)

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Infliximab ameliorates tumor necrosis factor ‐alpha‐induced insulin resistance by attenuating PTP1B activation in 3T3L1 adipocytes in vitro

Scandinavian Journal of Immunology,Volume 0, Issue ja, -Not available-. (Source: Scandinavian Journal of Immunology)

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Advances in asthma in 2017: Mechanism, biologics, and genetics

This review summarizes some of the most significant advances in asthma research over the past year. We first focus on novel discoveries in the mechanism of asthma development and exacerbation. This is followed by a discussion of potential new biomarkers, including the use of radiographic markers of disease. Several new biologics have become available to the clinician in the past year, and we summarize these advances and how they may influence the clinical delivery of asthma care. Following this, important findings in the genetics of asthma and heterogeneity in phenotypes of the disease are explored, as is the role the environment plays in shaping the development and exacerbation of asthma. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2MjOoUS

Allergy diagnosis from symptoms to molecules, or from molecules to symptoms: a comparative clinical study

ConclusionsFor the diagnostic verification of clinically suspected allergy, the novel concept "from molecules to clinic" offers a reliable diagnostic workup in shorter time. Due to lower skin test numbers it is especially applicable for young children and seniors, in atopic patients, and whenever skin tests get difficult or unreliable. (Source: World Allergy Organization Journal)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

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Comparing Asthma Control Questionnaire (ACQ) and National Asthma Education and Prevention Program (NAEPP) Asthma Control Criteria

Adequate assessment of control is critical to asthma management. The Asthma Control Questionnaire (ACQ) and the National Asthma Education and Prevention Program (NAEPP) criteria are commonly used measures of asthma control. (Source: Annals of Allergy, Asthma and Immunology)

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Penicillin allergy skin testing is safe in pre-lung transplant patients with low lung volumes

Penicillin allergy is the most frequently reported drug hypersensitivity reaction with a prevalence rate of around 10% in the US 1,2; however, true reactions exist in only around 3% of patients reporting a penicillin allergy 2. Penicillin allergy stigma results in higher health care costs and increased prevalence of multidrug resistant (MDR) organisms. In the pre-lung transplant population there are no data on penicillin skin testing in the setting of severely compromised lung function. (Source: Annals of Allergy, Asthma and Immunology)

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Microglia priming by interleukin-6 signaling is enhanced in aged mice

This study examined the functional role of IL-6 signaling on microglia priming. Our hypothesis is that IL-6 signaling mediates primed states of microglia in the aged. An initial study assessed age-related alteration in IL-6 signaling molecules; sIL-6R and sgp130 were measured in cerebrospinal fluid of young and aged wild-type animals. (Source: Journal of Neuroimmunology)

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Rhinitis in Children and Adolescents with Asthma: Ubiquitous, Difficult to Control, and Associated with Asthma Outcomes

Almost all children and adolescents with asthma have rhinitis of various, stable phenotypes based on sensitization and seasonal pattern. Conventional medications control rhinitis symptoms only in a minority. Difficult-to-control asthma is associated with worse rhinitis. (Source: Journal of Allergy and Clinical Immunology)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

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Artemisia pollen (mugwort) as a major vector for ambient LPS: brothers in harm?

(Source: Journal of Allergy and Clinical Immunology)

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Infliximab ameliorates tumor necrosis factor ‐alpha‐induced insulin resistance by attenuating PTP1B activation in 3T3L1 adipocytes in vitro

Scandinavian Journal of Immunology,Volume 0, Issue ja, -Not available-. (Source: Scandinavian Journal of Immunology)

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Advances in asthma in 2017: Mechanism, biologics, and genetics

This review summarizes some of the most significant advances in asthma research over the past year. We first focus on novel discoveries in the mechanism of asthma development and exacerbation. This is followed by a discussion of potential new biomarkers, including the use of radiographic markers of disease. Several new biologics have become available to the clinician in the past year, and we summarize these advances and how they may influence the clinical delivery of asthma care. Following this, important findings in the genetics of asthma and heterogeneity in phenotypes of the disease are explored, as is the role the environment plays in shaping the development and exacerbation of asthma. (Source: Journal of Allergy and Clinical Immunology)

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Distinguishing histopathologic features of acantholytic dermatoses and the pattern of acantholytic hypergranulosis

Journal of Cutaneous Pathology, Volume 0, Issue ja, -Not available-.


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Distinguishing histopathologic features of acantholytic dermatoses and the pattern of acantholytic hypergranulosis

Journal of Cutaneous Pathology, Volume 0, Issue ja, -Not available-.


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Quality of life among caregivers of sickle cell disease patients: a cross sectional study

To assess the quality of life (QoL) of caregivers of children with sickle cell disease (SCD) and to determine the risk factors associated with poor QoL.

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Quality of life of parents of very preterm infants 4 months after birth: a mixed methods study

Knowledge about parental quality of life (QoL) is paramount to family-centred and integrated healthcare on prematurity, but evidence is limited. We aimed to explore mothers' and fathers' perspectives about the...

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Mapping of the Gastrointestinal Short Form Questionnaire (GSF-Q) into EQ-5D-3L and SF-6D in patients with gastroesophageal reflux disease

The short, self-administered Gastroesophageal Reflux Disease (GERD) Symptom Frequency Questionnaire (GSFQ) is a specific Quality of Life (QoL) instrument which measures the impact of GERD symptoms on QoL. This...

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Quality of life among caregivers of sickle cell disease patients: a cross sectional study

To assess the quality of life (QoL) of caregivers of children with sickle cell disease (SCD) and to determine the risk factors associated with poor QoL.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2O5kwgp

Quality of life of parents of very preterm infants 4 months after birth: a mixed methods study

Knowledge about parental quality of life (QoL) is paramount to family-centred and integrated healthcare on prematurity, but evidence is limited. We aimed to explore mothers' and fathers' perspectives about the...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2oY8n2a

Mapping of the Gastrointestinal Short Form Questionnaire (GSF-Q) into EQ-5D-3L and SF-6D in patients with gastroesophageal reflux disease

The short, self-administered Gastroesophageal Reflux Disease (GERD) Symptom Frequency Questionnaire (GSFQ) is a specific Quality of Life (QoL) instrument which measures the impact of GERD symptoms on QoL. This...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2O7qUEb

Coronectomy Root Retrievals: A review of 92 cases

Coronectomy has become an increasingly prescribed surgical treatment for mandibular third molars deemed to pose a risk to the inferior dental nerve. The retention of the roots can have subsequent potential for root retrieval in the future if symptoms are reported. The long term outcome and symptoms leading to coronectomy root retrieval have not been well documented or studied which has understandably led to hesitation by some clinicians offering the procedure. The current series assesses the patients who have undergone root retrieval and their reported indication for removal as well as the histopathological status of the removed roots.

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Coronectomy Root Retrievals: A review of 92 cases

Coronectomy has become an increasingly prescribed surgical treatment for mandibular third molars deemed to pose a risk to the inferior dental nerve. The retention of the roots can have subsequent potential for root retrieval in the future if symptoms are reported. The long term outcome and symptoms leading to coronectomy root retrieval have not been well documented or studied which has understandably led to hesitation by some clinicians offering the procedure. The current series assesses the patients who have undergone root retrieval and their reported indication for removal as well as the histopathological status of the removed roots.

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Laryngeal Cancer| A Drug Pipeline Analysis Report| Technavio

Laryngeal Cancer| A Drug Pipeline Analysis Report| Technavio  Odessa AmericanFull coverage

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The use of asbestos can cause cancer – Lagos Commissioner

The use of asbestos can cause cancer – Lagos Commissioner  VanguardThe use of asbestos can cause cancer – commissioner  TODAY.NGFull coverage

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Laryngeal Cancer| A Drug Pipeline Analysis Report| Technavio

Laryngeal Cancer| A Drug Pipeline Analysis Report| Technavio  Odessa AmericanFull coverage

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The use of asbestos can cause cancer – Lagos Commissioner

The use of asbestos can cause cancer – Lagos Commissioner  VanguardThe use of asbestos can cause cancer – commissioner  TODAY.NGFull coverage

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2wVXphU

Advances in asthma in 2017: Mechanism, biologics, and genetics

This review summarizes some of the most significant advances in asthma research over the past year. We first focus on novel discoveries in the mechanism of asthma development and exacerbation. This is followed by a discussion of potential new biomarkers, including the use of radiographic markers of disease. Several new biologics have become available to the clinician in the past year, and we summarize these advances and how they may influence the clinical delivery of asthma care. Following this, important findings in the genetics of asthma and heterogeneity in phenotypes of the disease are explored, as is the role the environment plays in shaping the development and exacerbation of asthma.

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Rhinitis in Children and Adolescents with Asthma: Ubiquitous, Difficult to Control, and Associated with Asthma Outcomes

Almost all children and adolescents with asthma have rhinitis of various, stable phenotypes based on sensitization and seasonal pattern. Conventional medications control rhinitis symptoms only in a minority. Difficult-to-control asthma is associated with worse rhinitis.

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Artemisia pollen (mugwort) as a major vector for ambient LPS: brothers in harm?

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2x0TDDi

Advances in asthma in 2017: Mechanism, biologics, and genetics

This review summarizes some of the most significant advances in asthma research over the past year. We first focus on novel discoveries in the mechanism of asthma development and exacerbation. This is followed by a discussion of potential new biomarkers, including the use of radiographic markers of disease. Several new biologics have become available to the clinician in the past year, and we summarize these advances and how they may influence the clinical delivery of asthma care. Following this, important findings in the genetics of asthma and heterogeneity in phenotypes of the disease are explored, as is the role the environment plays in shaping the development and exacerbation of asthma.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2x0UoME

Rhinitis in Children and Adolescents with Asthma: Ubiquitous, Difficult to Control, and Associated with Asthma Outcomes

Almost all children and adolescents with asthma have rhinitis of various, stable phenotypes based on sensitization and seasonal pattern. Conventional medications control rhinitis symptoms only in a minority. Difficult-to-control asthma is associated with worse rhinitis.

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Artemisia pollen (mugwort) as a major vector for ambient LPS: brothers in harm?

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Laryngeal Cancer| A Drug Pipeline Analysis Report| Technavio

Laryngeal Cancer| A Drug Pipeline Analysis Report| Technavio  Business Wire (press release)Full coverage

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Ft. Zumwalt school community supports parent fighting cancer

Ft. Zumwalt school community supports parent fighting cancer  KSDK.comFull coverage

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Laryngeal Cancer| A Drug Pipeline Analysis Report| Technavio

Laryngeal Cancer| A Drug Pipeline Analysis Report| Technavio  Business Wire (press release)Full coverage

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Ft. Zumwalt school community supports parent fighting cancer

Ft. Zumwalt school community supports parent fighting cancer  KSDK.comFull coverage

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Italy Is Living Through What Happens When Politicians Embrace Anti-Vaxxers

Source: Huffingtonpost.com Author: Nick Robins-Early Italy's Five Star movement, which was founded by a man who once called HIV a hoax, […]

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Usefulness of preoperative three-dimensional volumetric analysis of carotid body tumors

Abstract

Purpose

The Shamblin classification is the commonest method to predict complications and outcomes during carotid body tumor (CBT) resection. The aim of this study is to describe the utility of the three-dimensional volumetric reconstruction (3DVR) analysis of the CBT and its relationship with postoperative outcomes.

Methods

Preoperative computed tomography angiography (CTA) was obtained to perform 3DVR of the CBT. Imaging data were analyzed and correlated with surgical outcomes: estimated blood loss (EBL), surgical time (ST), and hospital length of stay (HLOS). The Pearson test was used to determine the correlation between volume and postoperative outcomes.

Results

Fifty-seven patients were studied, 13 had Shamblin type I tumors with a mean 3DVR of 7.69 cm³ (standard deviation [SD 8.27]), 21 were type II with a mean 3DVR of 15.57 cm³ (SD 8.40), and 23 were type III with a mean 3DVR of 30.58 cm³ (SD 20.16). EBL mean was 559 milliliters (mL) (standard error [SE] 80.44), the mean ST of resection was 202 min (SD 67), and the mean HLOS was 5.8 days (SD 3.23). The Pearson test showed a correlation of r = 0.69 (p < 0.0001) between 3DVR and EBL, a r = 0.4 (p = 0.05) was obtained between 3DVR and ST, and finally, a r = 0.3 (p = 0.05) between 3DVR and HLOS was obtained.

Conclusion

The preoperative 3DVR determination of CBTs allows to analyze possible predictors of surgical outcomes. We found a positive correlation between the 3DVR volume and EBL. Further research is necessary to validate this method in the evaluation of these rare neoplasms.

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The sequence analysis of Epstein –Barr virus EBNA1 gene: could viral screening markers for nasopharyngeal carcinoma be identified?

AbstractEpstein –Barr virus (EBV) has been identified as a group 1 carcinogenic agent, particularly for nasopharyngeal carcinoma (NPC). The sequence diversity of EBV nuclear antigen 1 (EBNA1) reflects region-restricted polymorphisms, which may be associated with the development of certain malignancies. The aims o f the present study were to evaluate EBV EBNA1 gene polymorphisms circulating in NPC, infectious mononucleosis, and isolates from patients with transplanted organs to determine if EBNA1 sequence specificities are useful as viral biomarkers for NPC. Forty biopsies of undifferentiated carcinoma of nas opharyngeal type (UCNT), 31 plasma samples from patients with mononucleosis syndrome, and 16 plasma samples from patients after renal transplantation were tested in this study. The E...

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Role of pentamer complex-specific and IgG subclass 3 antibodies in HCMV hyperimmunoglobulin and standard intravenous IgG preparations

ConclusionVia specific antibody depletion, we could demonstrate that pentameric complex-specific antibodies are present in HIG and bind to the recombinant PC resulting in a highly significant reduction of NT-capacity compared to the UL130 TAN-and SWS-peptides. We could not confirm the functional role of IgG subclass 3 neutralizing antibodies in IgG-preparations. (Source: Medical Microbiology and Immunology)

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The sequence analysis of Epstein –Barr virus EBNA1 gene: could viral screening markers for nasopharyngeal carcinoma be identified?

AbstractEpstein –Barr virus (EBV) has been identified as a group 1 carcinogenic agent, particularly for nasopharyngeal carcinoma (NPC). The sequence diversity of EBV nuclear antigen 1 (EBNA1) reflects region-restricted polymorphisms, which may be associated with the development of certain malignancies. The aims o f the present study were to evaluate EBV EBNA1 gene polymorphisms circulating in NPC, infectious mononucleosis, and isolates from patients with transplanted organs to determine if EBNA1 sequence specificities are useful as viral biomarkers for NPC. Forty biopsies of undifferentiated carcinoma of nas opharyngeal type (UCNT), 31 plasma samples from patients with mononucleosis syndrome, and 16 plasma samples from patients after renal transplantation were tested in this study. The E...

MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2x495iA

Role of pentamer complex-specific and IgG subclass 3 antibodies in HCMV hyperimmunoglobulin and standard intravenous IgG preparations

ConclusionVia specific antibody depletion, we could demonstrate that pentameric complex-specific antibodies are present in HIG and bind to the recombinant PC resulting in a highly significant reduction of NT-capacity compared to the UL130 TAN-and SWS-peptides. We could not confirm the functional role of IgG subclass 3 neutralizing antibodies in IgG-preparations. (Source: Medical Microbiology and Immunology)

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Allergy diagnosis from symptoms to molecules, or from molecules to symptoms: a comparative clinical study

Abstract

Background

Classical allergy diagnostic workup "from symptoms to molecules" comprises 1) clinical investigation, 2) skin prick- and IgE- testing, and recently, 3) molecular allergy testing. We aimed to examine the diagnostic fidelity of the alternative approach "from molecules to symptoms", which was recently suggested in the EAACI Molecular Allergology User's Guide, in a retrospective clinical study.

Methods

Records from 202 patients with clinically suspected allergic sensitizations were extracted from files at two sites applying either the "ISAC-first" workup with IgE-testing by immuno-solid phase allergen chip ISAC112 followed by selected skin prick tests (SPT) or the "SPT-first" starting with SPT followed by the microarray test.

Results

In the ISAC-first procedure significantly less SPTs were performed during allergy diagnosis (median 4 vs. 14). By SPT in 19% of patients in the ISAC-first group and in 34% in the SPT-first group additional respiratory allergens (p = 0.014) were detected not positive in ISAC microarray. By ISAC microarray test 18% additional sensitizations were found in the ISAC-first, and 32% in SPT-first cohort (p = 0.016). For food allergens 13 and 12% additional sensitizations were detected by the microarray not detected by SPT in the two groups (p = 0.800). No additional food allergen was found by SPT in the ISAC-first group, while in 6% of the cases in the SPT-first group detected sensitizations were negative in the microarray.

Discussion

The ISAC-first approach followed by (fewer) SPTs meets the demands for a patient's tailored diagnostic work-up and therefore can be considered equivalent to the conventional way using the skin prick test as first screening tool, followed by IgE diagnosis.

Conclusions

For the diagnostic verification of clinically suspected allergy, the novel concept "from molecules to clinic" offers a reliable diagnostic workup in shorter time. Due to lower skin test numbers it is especially applicable for young children and seniors, in atopic patients, and whenever skin tests get difficult or unreliable.

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Allergy diagnosis from symptoms to molecules, or from molecules to symptoms: a comparative clinical study

Abstract

Background

Classical allergy diagnostic workup "from symptoms to molecules" comprises 1) clinical investigation, 2) skin prick- and IgE- testing, and recently, 3) molecular allergy testing. We aimed to examine the diagnostic fidelity of the alternative approach "from molecules to symptoms", which was recently suggested in the EAACI Molecular Allergology User's Guide, in a retrospective clinical study.

Methods

Records from 202 patients with clinically suspected allergic sensitizations were extracted from files at two sites applying either the "ISAC-first" workup with IgE-testing by immuno-solid phase allergen chip ISAC112 followed by selected skin prick tests (SPT) or the "SPT-first" starting with SPT followed by the microarray test.

Results

In the ISAC-first procedure significantly less SPTs were performed during allergy diagnosis (median 4 vs. 14). By SPT in 19% of patients in the ISAC-first group and in 34% in the SPT-first group additional respiratory allergens (p = 0.014) were detected not positive in ISAC microarray. By ISAC microarray test 18% additional sensitizations were found in the ISAC-first, and 32% in SPT-first cohort (p = 0.016). For food allergens 13 and 12% additional sensitizations were detected by the microarray not detected by SPT in the two groups (p = 0.800). No additional food allergen was found by SPT in the ISAC-first group, while in 6% of the cases in the SPT-first group detected sensitizations were negative in the microarray.

Discussion

The ISAC-first approach followed by (fewer) SPTs meets the demands for a patient's tailored diagnostic work-up and therefore can be considered equivalent to the conventional way using the skin prick test as first screening tool, followed by IgE diagnosis.

Conclusions

For the diagnostic verification of clinically suspected allergy, the novel concept "from molecules to clinic" offers a reliable diagnostic workup in shorter time. Due to lower skin test numbers it is especially applicable for young children and seniors, in atopic patients, and whenever skin tests get difficult or unreliable.

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Prof. Dr. Iyad Hassan Launches a New Website to Educate Patients on Endocrine and Cancer Diseases

Prof. Dr. Iyad Hassan Launches a New Website to Educate Patients on Endocrine and Cancer Diseases  Digital JournalFull coverage

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Mark Lawrenson's cancer diagnosis and other TV stars 'saved' by viewers

Mark Lawrenson's cancer diagnosis and other TV stars 'saved' by viewers  BBC NewsFull coverage

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Prof. Dr. Iyad Hassan Launches a New Website to Educate Patients on Endocrine and Cancer Diseases

Prof. Dr. Iyad Hassan Launches a New Website to Educate Patients on Endocrine and Cancer Diseases  Digital JournalFull coverage

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Mark Lawrenson's cancer diagnosis and other TV stars 'saved' by viewers

Mark Lawrenson's cancer diagnosis and other TV stars 'saved' by viewers  BBC NewsFull coverage

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4-D flow MRI aortic 3-D hemodynamics and wall shear stress remain stable over short-term follow-up in pediatric and young adult patients with bicuspid aortic valve

Abstract

Background

Children with bicuspid aortic valve (BAV) are at risk for serious complications including aortic valve stenosis and aortic rupture. Most studies investigating biomarkers predictive of BAV complications are focused on adults.

Objective

To investigate whether hemodynamic parameters change over time in children and young adults with BAV by comparing baseline and follow-up four-dimensional (4-D) flow MRI examinations.

Materials and methods

We retrospectively included 19 children and young adults with BAV who had serial 4-D flow MRI exams (mean difference in scan dates 1.8±1.0 [range, 0.6–3.4 years]). We compared aortic peak blood flow velocity, three-dimensional (3-D) wall shear stress, aortic root and ascending aortic (AAo) z-scores between baseline and follow-up exams. We generated systolic streamlines for all patients and visually compared their baseline and follow-up exams.

Results

The only significant difference between baseline and follow-up exams occurred in AAo z-scores (3.12±2.62 vs. 3.59±2.76, P<0.05) indicating growth of the AAo out of proportion to somatic growth. There were no significant changes in either peak velocity or 3-D wall shear stress between baseline and follow-up exams. Ascending aortic peak velocity at baseline correlated with annual change in AAo z-score (r=0.58, P=0.009). Visual assessment revealed abnormal blood flow patterns, which were unique to each patient and remained stable between baseline and follow-up exams.

Conclusion

In our pediatric and young adult BAV cohort, hemodynamic markers and systolic blood flow patterns remained stable over short-term follow-up despite significant AAo growth, suggesting minimal acute disease progression. Baseline AAo peak velocity was a predictor of AAo dilation and might help in determining pediatric patients with BAV who are at risk of increased AAo growth.

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4-D flow MRI aortic 3-D hemodynamics and wall shear stress remain stable over short-term follow-up in pediatric and young adult patients with bicuspid aortic valve

Abstract

Background

Children with bicuspid aortic valve (BAV) are at risk for serious complications including aortic valve stenosis and aortic rupture. Most studies investigating biomarkers predictive of BAV complications are focused on adults.

Objective

To investigate whether hemodynamic parameters change over time in children and young adults with BAV by comparing baseline and follow-up four-dimensional (4-D) flow MRI examinations.

Materials and methods

We retrospectively included 19 children and young adults with BAV who had serial 4-D flow MRI exams (mean difference in scan dates 1.8±1.0 [range, 0.6–3.4 years]). We compared aortic peak blood flow velocity, three-dimensional (3-D) wall shear stress, aortic root and ascending aortic (AAo) z-scores between baseline and follow-up exams. We generated systolic streamlines for all patients and visually compared their baseline and follow-up exams.

Results

The only significant difference between baseline and follow-up exams occurred in AAo z-scores (3.12±2.62 vs. 3.59±2.76, P<0.05) indicating growth of the AAo out of proportion to somatic growth. There were no significant changes in either peak velocity or 3-D wall shear stress between baseline and follow-up exams. Ascending aortic peak velocity at baseline correlated with annual change in AAo z-score (r=0.58, P=0.009). Visual assessment revealed abnormal blood flow patterns, which were unique to each patient and remained stable between baseline and follow-up exams.

Conclusion

In our pediatric and young adult BAV cohort, hemodynamic markers and systolic blood flow patterns remained stable over short-term follow-up despite significant AAo growth, suggesting minimal acute disease progression. Baseline AAo peak velocity was a predictor of AAo dilation and might help in determining pediatric patients with BAV who are at risk of increased AAo growth.

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The use of asbestos can cause cancer – Lagos Commissioner

The use of asbestos can cause cancer – Lagos Commissioner  VanguardNigeria: Lagos Govt Warns Against Use of Asbestos in Homes  AllAfrica.comFull coverage

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The use of asbestos can cause cancer – Lagos Commissioner

The use of asbestos can cause cancer – Lagos Commissioner  VanguardNigeria: Lagos Govt Warns Against Use of Asbestos in Homes  AllAfrica.comFull coverage

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Prof. Dr. Iyad Hassan Launches a New Website to Educate Patients on Endocrine and Cancer Diseases

Prof. Dr. Iyad Hassan Launches a New Website to Educate Patients on Endocrine and Cancer Diseases  Digital JournalFull coverage

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Prof. Dr. Iyad Hassan Launches a New Website to Educate Patients on Endocrine and Cancer Diseases

Prof. Dr. Iyad Hassan Launches a New Website to Educate Patients on Endocrine and Cancer Diseases  Digital JournalFull coverage

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When the theme is collaboration, labs get moving

UCLA Health Most people have, at one time or another, packed up all their belongings and lugged them to a new environment — a first dorm room, a bigger apartment, a different house. Few people, though, have had to pack up multiple million-dollar scientific instruments, boxes upon boxes of test tubes, pipettes and beakers, and scores of experiments at various stages of completion. Hundreds of researchers at the David Geffen School of Medicine at UCLA recently did just that.The reason was simple: School leaders wanted dramatically amplify the environment of collaboration that unites multidisciplinary teams in six research themes.The logistics were not: Coordinating the move of 33 labs into a central location — in just longer than a month and with minimum disruptions and downtime for on...

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When the theme is collaboration, labs get moving

UCLA Health Most people have, at one time or another, packed up all their belongings and lugged them to a new environment — a first dorm room, a bigger apartment, a different house. Few people, though, have had to pack up multiple million-dollar scientific instruments, boxes upon boxes of test tubes, pipettes and beakers, and scores of experiments at various stages of completion. Hundreds of researchers at the David Geffen School of Medicine at UCLA recently did just that.The reason was simple: School leaders wanted dramatically amplify the environment of collaboration that unites multidisciplinary teams in six research themes.The logistics were not: Coordinating the move of 33 labs into a central location — in just longer than a month and with minimum disruptions and downtime for on...

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

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Docs, Consumers Agree on Benefits of Virtual Care

But physician adoption of virtual care technologies is low; few plan to add video visit capability (Source: Pulmonary Medicine News - Doctors Lounge)

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Docs, Consumers Agree on Benefits of Virtual Care

But physician adoption of virtual care technologies is low; few plan to add video visit capability (Source: Pulmonary Medicine News - Doctors Lounge)

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A 'reset' of regulatory T-cells reverses chronic heart failure in mouse model

(University of Alabama at Birmingham) A severe heart attack, however, can cause chronic and sustained inflammation that leads to heart failure and death. In mouse experiments, scientists now have shown a way to hit an immunological 'reset button' that ends that inappropriately sustained inflammation. This reset reverses the pathologic enlargement and pumping failure of the heart, and it suggests a therapeutic approach to treating human heart failure. (Source: EurekAlert! - Medicine and Health)

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A 'reset' of regulatory T-cells reverses chronic heart failure in mouse model

(University of Alabama at Birmingham) A severe heart attack, however, can cause chronic and sustained inflammation that leads to heart failure and death. In mouse experiments, scientists now have shown a way to hit an immunological 'reset button' that ends that inappropriately sustained inflammation. This reset reverses the pathologic enlargement and pumping failure of the heart, and it suggests a therapeutic approach to treating human heart failure. (Source: EurekAlert! - Medicine and Health)

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Drug and chemical induced photosensitivity from a clinical perspective

Photochem. Photobiol. Sci., 2018, Accepted Manuscript
DOI: 10.1039/C8PP00011E, Perspective

Sally H Ibbotson
Drug photosensitivity is a relatively common occurrence and a range of mechanisms may be involved. Some of these mechanisms will be discussed, including the most common, that of drug phototoxicity....
The content of this RSS Feed (c) The Royal Society of Chemistry

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Drug and chemical induced photosensitivity from a clinical perspective

Photochem. Photobiol. Sci., 2018, Accepted Manuscript
DOI: 10.1039/C8PP00011E, Perspective

Sally H Ibbotson
Drug photosensitivity is a relatively common occurrence and a range of mechanisms may be involved. Some of these mechanisms will be discussed, including the most common, that of drug phototoxicity....
The content of this RSS Feed (c) The Royal Society of Chemistry

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When the theme is collaboration, labs get moving

UCLA Health Most people have, at one time or another, packed up all their belongings and lugged them to a new environment — a first dorm room, a bigger apartment, a different house. Few people, though, have had to pack up multiple million-dollar scientific instruments, boxes upon boxes of test tubes, pipettes and beakers, and scores of experiments at various stages of completion. Hundreds of researchers at the David Geffen School of Medicine at UCLA recently did just that.The reason was simple: School leaders wanted dramatically amplify the environment of collaboration that unites multidisciplinary teams in six research themes.The logistics were not: Coordinating the move of 33 labs into a central location — in just longer than a month and with minimum disruptions and downtime for on...

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When the theme is collaboration, labs get moving

UCLA Health Most people have, at one time or another, packed up all their belongings and lugged them to a new environment — a first dorm room, a bigger apartment, a different house. Few people, though, have had to pack up multiple million-dollar scientific instruments, boxes upon boxes of test tubes, pipettes and beakers, and scores of experiments at various stages of completion. Hundreds of researchers at the David Geffen School of Medicine at UCLA recently did just that.The reason was simple: School leaders wanted dramatically amplify the environment of collaboration that unites multidisciplinary teams in six research themes.The logistics were not: Coordinating the move of 33 labs into a central location — in just longer than a month and with minimum disruptions and downtime for on...

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Docs, Consumers Agree on Benefits of Virtual Care

But physician adoption of virtual care technologies is low; few plan to add video visit capability (Source: Pulmonary Medicine News - Doctors Lounge)

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Docs, Consumers Agree on Benefits of Virtual Care

But physician adoption of virtual care technologies is low; few plan to add video visit capability (Source: Pulmonary Medicine News - Doctors Lounge)

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A 'reset' of regulatory T-cells reverses chronic heart failure in mouse model

(University of Alabama at Birmingham) A severe heart attack, however, can cause chronic and sustained inflammation that leads to heart failure and death. In mouse experiments, scientists now have shown a way to hit an immunological 'reset button' that ends that inappropriately sustained inflammation. This reset reverses the pathologic enlargement and pumping failure of the heart, and it suggests a therapeutic approach to treating human heart failure. (Source: EurekAlert! - Medicine and Health)

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A 'reset' of regulatory T-cells reverses chronic heart failure in mouse model

(University of Alabama at Birmingham) A severe heart attack, however, can cause chronic and sustained inflammation that leads to heart failure and death. In mouse experiments, scientists now have shown a way to hit an immunological 'reset button' that ends that inappropriately sustained inflammation. This reset reverses the pathologic enlargement and pumping failure of the heart, and it suggests a therapeutic approach to treating human heart failure. (Source: EurekAlert! - Medicine and Health)

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Analysis of the effectiveness of training school personnel in the management of food allergy and anaphylaxis.

CONCLUSIONS: Our study demonstrates the usefulness of a self-efficacy scale in school personnel as a tool to assess the ability to manage food allergy and anaphylaxis. It can help to identify problem areas in which more specific training programs can be implemented. PMID: 30193885 [PubMed - as supplied by publisher] (Source: Allergologia et Immunopathologia)

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Asthma diagnosis in infants and preschool children: a systematic review of clinical guidelines.

CONCLUSIONS: There is generalized although not unanimous agreement that asthma can be diagnosed in preschool children. PMID: 30193886 [PubMed - as supplied by publisher] (Source: Allergologia et Immunopathologia)

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Contact sensitization in children with atopic dermatitis.

CONCLUSION: Cutaneous sensitization can develop in children with atopic dermatitis, therefore allergic contact dermatitis should be kept in mind. PMID: 30193890 [PubMed - as supplied by publisher] (Source: Allergologia et Immunopathologia)

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Subdiuretic dose of furosemide enhances albuterol effects in asthmatic mice rather than bumetanide.

CONCLUSIONS: Inhaled subdiuretic dose of furosemide enhanced effects of albuterol more in ovalbumin-asthmatic mice rather than bumetanide, while oral diuretic doses of both drugs failed to improve asthma, indicating that this enhancing effect is not diuretic-related. PMID: 30193887 [PubMed - as supplied by publisher] (Source: Allergologia et Immunopathologia)

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The profile of IL-4, IL-5, IL-10 and GATA3 in patients with LRBA deficiency and CVID with no known monogenic disease: Association with disease severity.

CONCLUSIONS: Our findings demonstrated that patients with CVID and LRBA deficiency (even with severe infectious and inflammatory complications) have not imbalance in Th2 response, which is in parallel with lower frequency of allergy and asthma in these patients. PMID: 30193889 [PubMed - as supplied by publisher] (Source: Allergologia et Immunopathologia)

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Detection of profilin in SPT extracts that are supposed to contain it.

CONCLUSION: The only accurate way to detect sensitization to profilin, while performing SPT, is the use of purified profilin extract. Even if a plant food or pollen contain an identified molecule of profilin, the relevant SPT commercial extract may not. PMID: 30193888 [PubMed - as supplied by publisher] (Source: Allergologia et Immunopathologia)

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Analysis of the effectiveness of training school personnel in the management of food allergy and anaphylaxis.

CONCLUSIONS: Our study demonstrates the usefulness of a self-efficacy scale in school personnel as a tool to assess the ability to manage food allergy and anaphylaxis. It can help to identify problem areas in which more specific training programs can be implemented. PMID: 30193885 [PubMed - as supplied by publisher] (Source: Allergologia et Immunopathologia)

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Asthma diagnosis in infants and preschool children: a systematic review of clinical guidelines.

CONCLUSIONS: There is generalized although not unanimous agreement that asthma can be diagnosed in preschool children. PMID: 30193886 [PubMed - as supplied by publisher] (Source: Allergologia et Immunopathologia)

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Contact sensitization in children with atopic dermatitis.

CONCLUSION: Cutaneous sensitization can develop in children with atopic dermatitis, therefore allergic contact dermatitis should be kept in mind. PMID: 30193890 [PubMed - as supplied by publisher] (Source: Allergologia et Immunopathologia)

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Subdiuretic dose of furosemide enhances albuterol effects in asthmatic mice rather than bumetanide.

CONCLUSIONS: Inhaled subdiuretic dose of furosemide enhanced effects of albuterol more in ovalbumin-asthmatic mice rather than bumetanide, while oral diuretic doses of both drugs failed to improve asthma, indicating that this enhancing effect is not diuretic-related. PMID: 30193887 [PubMed - as supplied by publisher] (Source: Allergologia et Immunopathologia)

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The profile of IL-4, IL-5, IL-10 and GATA3 in patients with LRBA deficiency and CVID with no known monogenic disease: Association with disease severity.

CONCLUSIONS: Our findings demonstrated that patients with CVID and LRBA deficiency (even with severe infectious and inflammatory complications) have not imbalance in Th2 response, which is in parallel with lower frequency of allergy and asthma in these patients. PMID: 30193889 [PubMed - as supplied by publisher] (Source: Allergologia et Immunopathologia)

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Detection of profilin in SPT extracts that are supposed to contain it.

CONCLUSION: The only accurate way to detect sensitization to profilin, while performing SPT, is the use of purified profilin extract. Even if a plant food or pollen contain an identified molecule of profilin, the relevant SPT commercial extract may not. PMID: 30193888 [PubMed - as supplied by publisher] (Source: Allergologia et Immunopathologia)

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Help the public understand radiation, advises cancer expert

Help the public understand radiation, advises cancer expert  World Nuclear NewsFull coverage

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Help the public understand radiation, advises cancer expert

Help the public understand radiation, advises cancer expert  World Nuclear NewsFull coverage

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Early-Stage Clinical Trial of Antimalarial Drug Begins

(NIH/National Institute of Allergy and Infectious Diseases) Enrollment has begun in a Phase 1 clinical trial to test the safety of a new investigational drug designed to treat malaria, as well as its effect on the human body. The first-in-human study is sponsored by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH), and is being conducted at the Duke University School of Medicine in Durham, North Carolina. (Source: EurekAlert! - Infectious and Emerging Diseases)

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Early-Stage Clinical Trial of Antimalarial Drug Begins

(NIH/National Institute of Allergy and Infectious Diseases) Enrollment has begun in a Phase 1 clinical trial to test the safety of a new investigational drug designed to treat malaria, as well as its effect on the human body. The first-in-human study is sponsored by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH), and is being conducted at the Duke University School of Medicine in Durham, North Carolina. (Source: EurekAlert! - Infectious and Emerging Diseases)

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Early-Stage Clinical Trial of Antimalarial Drug Begins

(NIH/National Institute of Allergy and Infectious Diseases) Enrollment has begun in a Phase 1 clinical trial to test the safety of a new investigational drug designed to treat malaria, as well as its effect on the human body. The first-in-human study is sponsored by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH), and is being conducted at the Duke University School of Medicine in Durham, North Carolina. (Source: EurekAlert! - Infectious and Emerging Diseases)

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Early-Stage Clinical Trial of Antimalarial Drug Begins

(NIH/National Institute of Allergy and Infectious Diseases) Enrollment has begun in a Phase 1 clinical trial to test the safety of a new investigational drug designed to treat malaria, as well as its effect on the human body. The first-in-human study is sponsored by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH), and is being conducted at the Duke University School of Medicine in Durham, North Carolina. (Source: EurekAlert! - Infectious and Emerging Diseases)

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Growth of Infants With Cow's Milk Allergy Fed an Amino Acid-based Formula Containing Two Human Milk Oligosaccharides

Condition:   Cow Milk Allergy Intervention:   Other: Food for Specific Medical Purpose Sponsor:   Nestlé Not yet recruiting (Source: ClinicalTrials.gov)

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Growth of Infants With Cow's Milk Allergy Fed an Amino Acid-based Formula Containing Two Human Milk Oligosaccharides

Condition:   Cow Milk Allergy Intervention:   Other: Food for Specific Medical Purpose Sponsor:   Nestlé Not yet recruiting (Source: ClinicalTrials.gov)

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A Methodology Development Environmental Clinical Trial of Reproxalap in Subjects With Seasonal Allergic Conjunctivitis

Condition:   Allergic Conjunctivitis Interventions:   Drug: Reproxalap Ophthalmic Solution (0.25%);   Drug: Reproxalap Ophthalmic Solution (0.5%);   Drug: Vehicle Ophthalmic Solution Sponsor:   Aldeyra Therapeutics, Inc. Not yet recruiting (Source: ClinicalTrials.gov)

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A Methodology Development Environmental Clinical Trial of Reproxalap in Subjects With Seasonal Allergic Conjunctivitis

Condition:   Allergic Conjunctivitis Interventions:   Drug: Reproxalap Ophthalmic Solution (0.25%);   Drug: Reproxalap Ophthalmic Solution (0.5%);   Drug: Vehicle Ophthalmic Solution Sponsor:   Aldeyra Therapeutics, Inc. Not yet recruiting (Source: ClinicalTrials.gov)

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To Evaluate the Efficacy and Safety of HL151 Versus Placebo in Perennial Allergic Rhinitis Patients

Condition:   Perennial Allergic Rhinitis Interventions:   Drug: HL151;   Drug: placebo Sponsor:   Hanlim Pharm. Co., Ltd. Completed (Source: ClinicalTrials.gov)

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To Evaluate the Efficacy and Safety of HL151 Versus Placebo in Perennial Allergic Rhinitis Patients

Condition:   Perennial Allergic Rhinitis Interventions:   Drug: HL151;   Drug: placebo Sponsor:   Hanlim Pharm. Co., Ltd. Completed (Source: ClinicalTrials.gov)

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Immune Response and Risk of Side Effects After Influenza Vaccination in Athletes

Conditions:   Influenza Virus Vaccine Adverse Reaction;   Influenza Vaccine Allergy Intervention:   Biological: Influenza Vaccination Sponsors:   Saarland University;   German Federal Institute of Sport Science Completed (Source: ClinicalTrials.gov)

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Immune Response and Risk of Side Effects After Influenza Vaccination in Athletes

Conditions:   Influenza Virus Vaccine Adverse Reaction;   Influenza Vaccine Allergy Intervention:   Biological: Influenza Vaccination Sponsors:   Saarland University;   German Federal Institute of Sport Science Completed (Source: ClinicalTrials.gov)

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Effects of irradiation with narrowband-ultraviolet B on up-regulation of histamine H1 receptor mRNA and induction of apoptosis in HeLa cells and nasal mucosa of rats

Publication date: Available online 10 September 2018Source: Journal of Pharmacological SciencesAuthor(s): Tatsuya Fujii, Yoshiaki Kitamura, Hiroyuki Mizuguchi, Kentaro Okamoto, Nanae Sanada, Takuya Yamada, Manabu Sugiyama, Shotaro Michinaga, Mika Kitayama, Hiroyuki Fukui, Noriaki TakedaAbstractNarrowband-ultraviolet B (NB-UVB) phototherapy is used for the treatment of atopic dermatitis. Previously, we reported that irradiation with 200 mJ/cm2 of 310 nm NB-UVB suppressed phorbol-12-myristate-13-acetate (PMA)-induced up-regulation of histamine H1 receptor (H1R) gene expression without induction of apoptosis in HeLa cells. However, the effect of NB-UVB irradiation on nasal symptoms is still unclear. Here, we show that low dose irradiation with 310 nm NB-UVB alleviates nasal symptoms in toluen...

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Mite Asthma Pediatric Immunotherapy Trial

Conditions:   Allergic Asthma Due to Dermatophagoides Farinae;   Allergic Asthma Due to Dermatophagoides Pteronyssinus;   Allergic Rhinitis Due to House Dust Mite Interventions:   Biological: HDM SLIT-tablet;   Other: Placebo Sponsor:   ALK-Abelló A/S Recruiting (Source: ClinicalTrials.gov)

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Mite Asthma Pediatric Immunotherapy Trial

Conditions:   Allergic Asthma Due to Dermatophagoides Farinae;   Allergic Asthma Due to Dermatophagoides Pteronyssinus;   Allergic Rhinitis Due to House Dust Mite Interventions:   Biological: HDM SLIT-tablet;   Other: Placebo Sponsor:   ALK-Abelló A/S Recruiting (Source: ClinicalTrials.gov)

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Effects of irradiation with narrowband-ultraviolet B on up-regulation of histamine H1 receptor mRNA and induction of apoptosis in HeLa cells and nasal mucosa of rats

Publication date: Available online 10 September 2018Source: Journal of Pharmacological SciencesAuthor(s): Tatsuya Fujii, Yoshiaki Kitamura, Hiroyuki Mizuguchi, Kentaro Okamoto, Nanae Sanada, Takuya Yamada, Manabu Sugiyama, Shotaro Michinaga, Mika Kitayama, Hiroyuki Fukui, Noriaki TakedaAbstractNarrowband-ultraviolet B (NB-UVB) phototherapy is used for the treatment of atopic dermatitis. Previously, we reported that irradiation with 200 mJ/cm2 of 310 nm NB-UVB suppressed phorbol-12-myristate-13-acetate (PMA)-induced up-regulation of histamine H1 receptor (H1R) gene expression without induction of apoptosis in HeLa cells. However, the effect of NB-UVB irradiation on nasal symptoms is still unclear. Here, we show that low dose irradiation with 310 nm NB-UVB alleviates nasal symptoms in toluen...

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Letter: Minnetonka should raise tobacco sales age to 21

Letter: Minnetonka should raise tobacco sales age to 21  ECM PublishersFull coverage

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Letter: Minnetonka should raise tobacco sales age to 21

Letter: Minnetonka should raise tobacco sales age to 21  ECM PublishersFull coverage

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Ask a Specialist: Thyroid Cancer - The Queen's Medical Center

Ask a Specialist: Thyroid Cancer - The Queen's Medical Center  KHON2Full coverage

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Ask a Specialist: Thyroid Cancer - The Queen's Medical Center

Ask a Specialist: Thyroid Cancer - The Queen's Medical Center  KHON2Full coverage

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Adolescents, parents and teachers’ perceptions of risk and protective factors of substance use in Moroccan adolescents: a qualitative study

Substance use in adolescents is a global public health concern that continues to draw attention from academics, policy experts, and government officials. In Morocco, few studies have investigated the influenci...

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Adolescents, parents and teachers’ perceptions of risk and protective factors of substance use in Moroccan adolescents: a qualitative study

Substance use in adolescents is a global public health concern that continues to draw attention from academics, policy experts, and government officials. In Morocco, few studies have investigated the influenci...

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Versatility of uniplanar prearthoplastic distraction osteogenesis in the correction of post-ankylosis facial deformities —a report of five different cases

ConclusionPre-arthroplastic distraction osteogenesis is a versatile cost effective approach that can be customized for every patient based on their needs. (Source: Oral and Maxillofacial Surgery)

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Versatility of uniplanar prearthoplastic distraction osteogenesis in the correction of post-ankylosis facial deformities —a report of five different cases

ConclusionPre-arthroplastic distraction osteogenesis is a versatile cost effective approach that can be customized for every patient based on their needs. (Source: Oral and Maxillofacial Surgery)

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Laryngeal Cancer| A Drug Pipeline Analysis Report| Technavio

Laryngeal Cancer| A Drug Pipeline Analysis Report| Technavio  Hastings TribuneFull coverage

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Laryngeal Cancer| A Drug Pipeline Analysis Report| Technavio

Laryngeal Cancer| A Drug Pipeline Analysis Report| Technavio  Hastings TribuneFull coverage

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Men Who Survive Thyroid Cancer Have Higher Risk of CVD vs Women

Men Who Survive Thyroid Cancer Have Higher Risk of CVD vs Women  Endocrinology Network (press release) (blog)Full coverage

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Thyroid Cancer Webchat

Thyroid Cancer Webchat  ABC27Full coverage

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Men Who Survive Thyroid Cancer Have Higher Risk of CVD vs Women

Men Who Survive Thyroid Cancer Have Higher Risk of CVD vs Women  Endocrinology Network (press release) (blog)Full coverage

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Thyroid Cancer Webchat

Thyroid Cancer Webchat  ABC27Full coverage

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Monitoring the Nervous System for Anesthesiologists and Other Health Care Professionals, Second Edition

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A survey of medication preparation and administration practices among members of the Canadian Anesthesiologists’ Society

Abstract

Purpose

Recommendations for safe medication injection practices to eliminate the risk of patient-to-patient transmission of blood-borne infections have been in place for many years. The purpose of our study was to evaluate the medication administration practices of Canadian anesthesiologists relative to current safe practice guidelines.

Methods

An anonymous 17-question online survey was sent to all members of the Canadian Anesthesiologists' Society (CAS) via the membership email list. Data pertaining to respondent demographics, practice characteristics, and medication preparation and administration practices were collected and analyzed descriptively using frequencies and percentages as well as Fisher's exact tests followed by post hoc multiple comparisons.

Results

Of the 2,656 CAS members, 546 (21%) responded. The practice of reusing needles (2%) and/or syringes (7%) between patients is reported by only a minority of practitioners; however, sharing a medication vial between more than one patient using new needles and syringes is still widely practiced with 83% doing this sometimes or routinely. The main reasons for sharing medications include the desire to reduce medication waste and the associated costs.

Conclusion

Sharing medication vials between multiple patients is common practice in Canada, with new needles and syringes used for each patient. Unfortunately, a small minority of anesthesiologists continue to reuse needles and/or syringes between patients, and this may pose a significant risk of patient-to-patient infection transmission.

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Improving communication, teamwork, and action during a “cannot intubate cannot oxygenate (CICO)” emergency: employing CICO as a cognitive aid mnemonic

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A survey of medication preparation and administration practices among members of the Canadian Anesthesiologists’ Society

Abstract

Purpose

Recommendations for safe medication injection practices to eliminate the risk of patient-to-patient transmission of blood-borne infections have been in place for many years. The purpose of our study was to evaluate the medication administration practices of Canadian anesthesiologists relative to current safe practice guidelines.

Methods

An anonymous 17-question online survey was sent to all members of the Canadian Anesthesiologists' Society (CAS) via the membership email list. Data pertaining to respondent demographics, practice characteristics, and medication preparation and administration practices were collected and analyzed descriptively using frequencies and percentages as well as Fisher's exact tests followed by post hoc multiple comparisons.

Results

Of the 2,656 CAS members, 546 (21%) responded. The practice of reusing needles (2%) and/or syringes (7%) between patients is reported by only a minority of practitioners; however, sharing a medication vial between more than one patient using new needles and syringes is still widely practiced with 83% doing this sometimes or routinely. The main reasons for sharing medications include the desire to reduce medication waste and the associated costs.

Conclusion

Sharing medication vials between multiple patients is common practice in Canada, with new needles and syringes used for each patient. Unfortunately, a small minority of anesthesiologists continue to reuse needles and/or syringes between patients, and this may pose a significant risk of patient-to-patient infection transmission.

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Improving communication, teamwork, and action during a “cannot intubate cannot oxygenate (CICO)” emergency: employing CICO as a cognitive aid mnemonic

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Comments on “Anesthesia for interventional pulmonology procedures: a review of advanced diagnostic and therapeutic bronchoscopy”

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Anesthesia and Neurotoxicity, First Edition

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Monitoring the Nervous System for Anesthesiologists and Other Health Care Professionals, Second Edition

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In reply: Comments on “Anesthesia for interventional pulmonology procedures: a review of advanced diagnostic and therapeutic bronchoscopy”

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Comments on “Anesthesia for interventional pulmonology procedures: a review of advanced diagnostic and therapeutic bronchoscopy”

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Canadian Critical Care Society revised process for guideline development and endorsement

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Anesthesia and Neurotoxicity, First Edition

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Mechanism of the erector spinae plane block: insights from a magnetic resonance imaging study

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In reply: Comments on “Anesthesia for interventional pulmonology procedures: a review of advanced diagnostic and therapeutic bronchoscopy”

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In at the start: recollections of the early days of critical care in Toronto

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A multicentre investigation of organ and tissue donation education for critical care residents

Abstract

Purpose

To describe critical care medicine residents' training, expertise, and skills regarding organ and tissue donation processes and procedures.

Methods

We undertook a qualitative multicentre study and employed a purposive sample of program directors, physicians, nurses, residents, and organ donation leaders from all nine academic intensive care unit (ICU) training centres (five adult, four pediatric) in Ontario (n = 71). Interviews, conducted by telephone between December 2015 and March 2016, were audio-recorded and transcribed verbatim. Data collection and analysis were performed using an iterative process and continued until saturation was achieved.

Results

Five main themes were identified: 1) gaps in residents' knowledge for both neurologic determination of death (NDD) and circulatory determination of death (DCD) cases; 2) commitment to the provision of organ and tissue donation training; 3) limited experiential learning (NDD and DCD); 4) challenges related to the provision of training on organ donation and need for a standardized curriculum; and 5) communication with family members. Overall, this study showed system-level gaps in training resulting from the lack of a standardized provincial curriculum on organ donation.

Conclusions

Qualitative data corroborated that residents need more exposure to clinical cases, especially regarding DCD donors. A standardized education curriculum would be beneficial for all residents within the ICU. Developing a better shared understanding of the donation process will improve team communication and performance, translate into a better end-of-life experience for families, and potentially result in increased donation rates.

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Canadian Critical Care Society revised process for guideline development and endorsement

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