Aerobiology of Cupressaceae in Porto city, Portugal

AbstractIn the last years, pollen-related respiratory allergies have increased worldwide. In the case of Cupressaceae pollen, allergy symptoms appearing during the winter are often confused with generic respiratory diseases such as the common cold, influenza syndrome, among others. The aim of our study was to monitor the atmospheric of Cupressaceae pollen in the city of Porto, investigate its diurnal variation, as well as find the meteorological factors influencing its atmospheric concentration. Airborne pollen sampling was performed using a 7-day Hirst-type volumetric spore trap for 5  years (2013–2017). Cupressaceae main pollen season, interannual and diurnal variations, as well as correlations with the meteorological parameters were determined. During the study period, 2015 was the y...

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Sequence analysis of isolates of Aspergillus from patients with chronic and allergic aspergillosis reveals a spectrum of cryptic species

Future Microbiology, Ahead of Print. (Source: Future Microbiology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2B2mSIR

Aerobiology of Cupressaceae in Porto city, Portugal

AbstractIn the last years, pollen-related respiratory allergies have increased worldwide. In the case of Cupressaceae pollen, allergy symptoms appearing during the winter are often confused with generic respiratory diseases such as the common cold, influenza syndrome, among others. The aim of our study was to monitor the atmospheric of Cupressaceae pollen in the city of Porto, investigate its diurnal variation, as well as find the meteorological factors influencing its atmospheric concentration. Airborne pollen sampling was performed using a 7-day Hirst-type volumetric spore trap for 5  years (2013–2017). Cupressaceae main pollen season, interannual and diurnal variations, as well as correlations with the meteorological parameters were determined. During the study period, 2015 was the y...

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2JZhLMr

Sequence analysis of isolates of Aspergillus from patients with chronic and allergic aspergillosis reveals a spectrum of cryptic species

Future Microbiology, Ahead of Print. (Source: Future Microbiology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2B2mSIR

Strategies for Person-Centered Approach to Mild TBI: An Interprofessional Perspective

Approximately 42 million people worldwide experience mild traumatic brain injury (mTBI) each year. Even if they don't exhibit verifiable cognitive symptoms, they might experience cognitive inefficiency in their daily lives. How can health care professionals, such as speech-language pathologists and psychologists, help them? The Joint Committee on Interprofessional Relations of ASHA and the American Psychological Association (APA) suggests taking a person-centered approach to treatment that focuses on education, counseling, and use of compensatory strategies to help patients re-engage in meaningful daily activities. A person-centered approach to mTBI treatment understands that people with mild brain injury can identify their symptoms and challenges. This ability allows them to use facilit...

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2zKwSVo

Strategies for Person-Centered Approach to Mild TBI: An Interprofessional Perspective

Approximately 42 million people worldwide experience mild traumatic brain injury (mTBI) each year. Even if they don't exhibit verifiable cognitive symptoms, they might experience cognitive inefficiency in their daily lives. How can health care professionals, such as speech-language pathologists and psychologists, help them? The Joint Committee on Interprofessional Relations of ASHA and the American Psychological Association (APA) suggests taking a person-centered approach to treatment that focuses on education, counseling, and use of compensatory strategies to help patients re-engage in meaningful daily activities. A person-centered approach to mTBI treatment understands that people with mild brain injury can identify their symptoms and challenges. This ability allows them to use facilit...

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2zKwSVo

Effects of oral ısotretinoin on normal and wounded nasal mucosa: an experimental study

Abstract

Background

We aimed to investigate the effect of systemic isotretinoin therapy on normal and wounded nasal septal mucosa histopathologically in an experimental rabbit model.

Methods

Circular mucosal defect with a 7 mm diameter was made in the left septum of 12 New Zealand white rabbits. The rabbits were divided into two groups (six rabbits in each group) oral isotretinoin was given with olive oil at the operation day to the first group. The control group was only oil given group. The harvested septum mucosas were divided into four groups (1—wounded-drug given side, 2—unwounded and drug-given side, 3—wounded-control and 4—unwounded-control side). The diameter of the defect, mucosal thickness, epithelial thickness, ciliated cell level, goblet cell level and inflammation were evaluated every week for 4 weeks.

Results

At both wounded and normal side, thinning of normal respiratory ciliated epithelium was observed in the postoperative period. In study group at the wounded side; mean mucosal thickness was measured 139.66 µ (± 26.24), and in the control group, mean mucosal thickness was 238.33 µ (± 39.7) at the wounded side. (p < 0.001). The difference between the groups in thickness of normal septal mucosa was also statistically significant (p = 0.016) [190 µ (± 14.6) and 256.66 µ (± 44.66)]. The average cilia level was observed 1.16 in the wounded study group, while the average level was 2.33 in the wounded control group (p = 0.012). Average score measurements of the regenerated mucosa suggested that isotretinoin–given wounded animals have reduced goblet cell recovery, compared to the control both on the regenerated and unwounded mucosas (p = 0.007, p = 0.002, respectively). Inflammation was significantly higher in the wounded isotretinoin group (p = 0.018).

Conclusion

Oral isotretinoin has negative effects on epithelial and ciliary regeneration, significantly reduces mucosal thickness and goblet cell counts of the normal and regenerated mucosa, causes severe inflammation and significant reactive changes.

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Cervical inlet patch: an important cause of Globus pharyngeus

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PScnQS

Reply to: Angulation of the ossified stylohyoid complex and Eagle syndrome

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Di9xh7

Commentary to: Predictable prosthesis length on a high-resolution CT scan before a stapedotomy

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PScmfM

Angulation of the ossified stylohyoid complex and Eagle syndrome

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2DgYK6Y

Evaluation of saccular and inferior vestibular nerve function in children with auditory neuropathy spectrum disorder

Abstract

Purpose

The aim of the current work was to evaluate the function of the saccule and inferior vestibular nerve in children with auditory neuropathy spectrum disorder (ANSD) by recording the cervical-evoked myogenic potentials (C-VEMP) on those children and to compare C-VEMP results in ANSD children of pre-lingual onset to those in ANSD children of post-lingual onset.

Methods

The study included 38 ANSD children of pre-lingual onset, 16 ANSD children of post-lingual onset, and 20 control children. All participant children were subjected to C-VEMP testing using 500 Hz tone burst stimuli.

Results

The vast majority of ANSD children of pre-lingual onset (35 out of 38; 92.1%) had bilateral intact C-VEMP response with C-VEMP parameters (amplitude, asymmetric ratio, latency, and inter-aural latency difference) that were not statistically different than those in the control children. Only three children had bilateral absent C-VEMP response. On the other hand, the majority of ANSD children of post-lingual onset (11 out of 16; 68.75%) had bilateral absent C-VEMP response. The remaining five children had bilateral intact C-VEMP response with C-VEMP parameters that were not statistically different than those in the control children.

Conclusions

The pathology of ANSD spares the saccule and inferior vestibular nerve in the vast majority of ANSD children of pre-lingual onset, while it involves them in the majority of ANSD of post-lingual onset reflecting different site(s) of lesion between the two ANSD categories. Such results have important clinical implications as regards to the management of ANSD in children.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PSchZw

Authors’ response to Commentary on “Role of barium swallow pharyngoesophagography in the management of globus pharyngeus”

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2DisYq9

Role of barium swallow pharyngoesophagography in the management of globus pharyngeus

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PQd7G7

Clinical classification of cervical necrotizing fasciitis

Abstract

Purpose

Necrotizing fasciitis of the craniofacial region is a rare and potentially life-threatening bacterial infectious disease. Odontogenic infections primarily spread along facial fascia and subcutaneous tissues, resulting in upper chest skin or thoracic necrosis. The purpose of this clinical classification was to demonstrate clinically important guidelines for early diagnosis and prompt management of CNF.

Methods

Although the incidence of cervical necrotizing fasciitis (CNF) is very rare in many developed countries, prompt management with appropriate initial diagnosis is essential, especially in tropical low-economic rural regions of African countries. Over the last 12 years, our charitable team in West Africa made clinical classifications of CNF according to onset time and spreading pattern to thoracic extension.

Results

CNF patients could be divided into two primary types, limited to neck type and extended to upper chest type. We also further categorized from each type into three different groups according to the CNF onset and clinical characteristics, including acute type with hematogenous spread within 2 weeks, subacute type with suppuration over 2 to 4 weeks, chronic type without suppuration over 4 weeks, multiple type with partial skin necrosis, island type with necrotic skin coverage, and broad type with whole skin necrosis.

Conclusions

These classifications will help decrease the mortality rate in severely infected patients.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2DhSNXm

Expression of matrix metalloproteinases (MMPs-2, -7, -9, and -26) and tissue inhibitors of metalloproteinases (TIMPs-1 and -2) in pleomorphic adenomas and adenoid cystic carcinomas

Abstract

Purpose

To compare the immunohistochemical expression of matrix metalloproteinases-2, -7, -9 and -26 and tissue inhibitors of metalloproteinases-1 and -2 in pleomorphic adenomas and adenoid cystic carcinomas of the minor salivary glands.

Methods

Twenty cases of pleomorphic adenomas and 20 cases of adenoid cystic carcinomas were evaluated for the immunohistochemical expression of matrix metalloproteinases-2, -7, -9, and -26 and tissue inhibitors-1 and -2 in tumor parenchyma.

Results

Most pleomorphic adenomas and adenoid cystic carcinomas showed high expression of matrix metalloproteinases and tissue inhibitors, predominantly located in the tumor cells. There was no statistically significant difference in the expression of the metalloproteinases-2 (p = 0.359), -7 (p = 0.081), and -26 (p = 0 553), as well as the tissue inhibitors-1 (p = 0.657), and -2 (p = 0.248) between the parenchyma of the studied tumors. Only matrix metalloproteinase-9 showed a significant difference in expression between the two tumors, with adenoid cystic carcinoma showing a more intense staining for this gelatinase (p = 0.041).

Conclusions

The expression of the studied metalloproteinases suggests the involvement of these enzymes in the tissue remodeling process in pleomorphic adenomas and adenoid cystic carcinomas, but only MMP-9, significantly expressed in the adenoid cystic carcinomas, appears to be involved in the process of invasiveness and more aggressive behavior of these tumors. Additionally, results point that TIMPs-1 and -2 may have more complex functions besides metalloproteinase inhibition, which may be related to the pathogenesis and biological behavior of salivary gland tumors.

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The effect of ectodermal dysplasia on volume and surface area of maxillary sinus

Abstract

Purpose

Ectodermal dysplasia (ED) is a congenital syndrome characterized by abnormal development of ectodermal structures, such as skin, hair, nails, teeth, or salivary glands. Patients with ED demonstrate craniofacial dysmorphology, midfacial hypoplasia and hypodontia. The aim of this study is to evaluate volume and surface area of maxillary sinus and craniofacial structures in patients with ectodermal dysplasia (ED) using cone-beam computed tomography (CBCT) images.

Methods

The CBCT images of 20 patients with ED (study group) and 20 healthy individuals (control) which are equal in terms of age and gender were evaluated. After a three-dimensional analysis and segmentation of each maxillary sinus, the volume and surface area were calculated. Craniofacial dimensions were measured on the sagittal planes of the CBCT images. The results of the ED and control groups were statistically compared.

Results

The right and left sinus volumes and surface areas were significantly lower in the ED group than in the control group (p < 0.05) while the SNA was significantly higher (p < 0.05). ANB and SN-GoMe were also lower in patients with ED than in controls (p < 0.05). The difference in SNB values between the two groups was not significant (p > 0.05).

Conclusions

The volumes and surface areas of both maxillary sinuses were found to be smaller in patients with ED compared to healthy individuals. Class III malocclusion with maxillary retrusion is a characteristic craniofacial feature of these patients.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PX46uN

Evaluation of upper esophageal sphincter in benign vocal lesions

Abstract

Purpose

To evaluate upper esophageal sphincter (UES) activity in patients with benign glottic lesions.

Methods

Twenty-three patients with benign vocal fold (VF) lesions scheduled for manometric evaluation were enrolled as the study group (SG); 20 healthy subjects without vocal pathology or dysphagia were included as the control group (CG). UES residual, basal, relaxation time and peak pharyngeal pressures were evaluated by manometry. The reflux symptom index (RSI) and reflux finding score (RFS) were used to estimate the clinical findings of laryngopharyngeal reflux, and the voice handicap index (VHI) was measured in both groups. The patients' data were compared using the Mann–Whitney test and t test.

Results

The diagnoses in the SG were vocal nodules, vocal polyps, vocal cysts, sulcus vocalis, or Reinke's edema. The evaluation scores (RSI, RFS, and VHI) were significantly higher in the SG than in the CG (P < 0.05). UES basal and relaxation pressures, relaxation time, and peak pharyngeal pressures did not differ between the SG and the CG (P > 0.05).

Conclusion

UES manometric pressure was similar in patients with VF mucosal lesions and controls. Studies involving larger populations are necessary to confirm the manometric changes in the UES and to elucidate the pathogenesis of benign VF lesions.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Dj65mv

Effects of oral ısotretinoin on normal and wounded nasal mucosa: an experimental study

Abstract

Background

We aimed to investigate the effect of systemic isotretinoin therapy on normal and wounded nasal septal mucosa histopathologically in an experimental rabbit model.

Methods

Circular mucosal defect with a 7 mm diameter was made in the left septum of 12 New Zealand white rabbits. The rabbits were divided into two groups (six rabbits in each group) oral isotretinoin was given with olive oil at the operation day to the first group. The control group was only oil given group. The harvested septum mucosas were divided into four groups (1—wounded-drug given side, 2—unwounded and drug-given side, 3—wounded-control and 4—unwounded-control side). The diameter of the defect, mucosal thickness, epithelial thickness, ciliated cell level, goblet cell level and inflammation were evaluated every week for 4 weeks.

Results

At both wounded and normal side, thinning of normal respiratory ciliated epithelium was observed in the postoperative period. In study group at the wounded side; mean mucosal thickness was measured 139.66 µ (± 26.24), and in the control group, mean mucosal thickness was 238.33 µ (± 39.7) at the wounded side. (p < 0.001). The difference between the groups in thickness of normal septal mucosa was also statistically significant (p = 0.016) [190 µ (± 14.6) and 256.66 µ (± 44.66)]. The average cilia level was observed 1.16 in the wounded study group, while the average level was 2.33 in the wounded control group (p = 0.012). Average score measurements of the regenerated mucosa suggested that isotretinoin–given wounded animals have reduced goblet cell recovery, compared to the control both on the regenerated and unwounded mucosas (p = 0.007, p = 0.002, respectively). Inflammation was significantly higher in the wounded isotretinoin group (p = 0.018).

Conclusion

Oral isotretinoin has negative effects on epithelial and ciliary regeneration, significantly reduces mucosal thickness and goblet cell counts of the normal and regenerated mucosa, causes severe inflammation and significant reactive changes.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2DgCJoS

Cervical inlet patch: an important cause of Globus pharyngeus

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PScnQS

Reply to: Angulation of the ossified stylohyoid complex and Eagle syndrome

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Di9xh7

Commentary to: Predictable prosthesis length on a high-resolution CT scan before a stapedotomy

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PScmfM

Angulation of the ossified stylohyoid complex and Eagle syndrome

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2DgYK6Y

Evaluation of saccular and inferior vestibular nerve function in children with auditory neuropathy spectrum disorder

Abstract

Purpose

The aim of the current work was to evaluate the function of the saccule and inferior vestibular nerve in children with auditory neuropathy spectrum disorder (ANSD) by recording the cervical-evoked myogenic potentials (C-VEMP) on those children and to compare C-VEMP results in ANSD children of pre-lingual onset to those in ANSD children of post-lingual onset.

Methods

The study included 38 ANSD children of pre-lingual onset, 16 ANSD children of post-lingual onset, and 20 control children. All participant children were subjected to C-VEMP testing using 500 Hz tone burst stimuli.

Results

The vast majority of ANSD children of pre-lingual onset (35 out of 38; 92.1%) had bilateral intact C-VEMP response with C-VEMP parameters (amplitude, asymmetric ratio, latency, and inter-aural latency difference) that were not statistically different than those in the control children. Only three children had bilateral absent C-VEMP response. On the other hand, the majority of ANSD children of post-lingual onset (11 out of 16; 68.75%) had bilateral absent C-VEMP response. The remaining five children had bilateral intact C-VEMP response with C-VEMP parameters that were not statistically different than those in the control children.

Conclusions

The pathology of ANSD spares the saccule and inferior vestibular nerve in the vast majority of ANSD children of pre-lingual onset, while it involves them in the majority of ANSD of post-lingual onset reflecting different site(s) of lesion between the two ANSD categories. Such results have important clinical implications as regards to the management of ANSD in children.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PSchZw

Authors’ response to Commentary on “Role of barium swallow pharyngoesophagography in the management of globus pharyngeus”

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2DisYq9

Role of barium swallow pharyngoesophagography in the management of globus pharyngeus

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PQd7G7

Clinical classification of cervical necrotizing fasciitis

Abstract

Purpose

Necrotizing fasciitis of the craniofacial region is a rare and potentially life-threatening bacterial infectious disease. Odontogenic infections primarily spread along facial fascia and subcutaneous tissues, resulting in upper chest skin or thoracic necrosis. The purpose of this clinical classification was to demonstrate clinically important guidelines for early diagnosis and prompt management of CNF.

Methods

Although the incidence of cervical necrotizing fasciitis (CNF) is very rare in many developed countries, prompt management with appropriate initial diagnosis is essential, especially in tropical low-economic rural regions of African countries. Over the last 12 years, our charitable team in West Africa made clinical classifications of CNF according to onset time and spreading pattern to thoracic extension.

Results

CNF patients could be divided into two primary types, limited to neck type and extended to upper chest type. We also further categorized from each type into three different groups according to the CNF onset and clinical characteristics, including acute type with hematogenous spread within 2 weeks, subacute type with suppuration over 2 to 4 weeks, chronic type without suppuration over 4 weeks, multiple type with partial skin necrosis, island type with necrotic skin coverage, and broad type with whole skin necrosis.

Conclusions

These classifications will help decrease the mortality rate in severely infected patients.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2DhSNXm

Activations of group 2 innate lymphoid cells depend on endotypes of chronic rhinosinusitis

Abstract

Objective

Chronic rhinosinusitis (CRS) is a complicated disease with several variants caused by different cellular and molecular mechanisms. The characterization of this heterogeneity supports the definition that the disease consists of many endotypes, such as eosinophilic and neutrophilic CRS, and so on. This study aimed to explore group 2 innate lymphoid cells (ILC2s) in neutrophilic CRS without nasal polyps (CRSsNP) and with nasal polyps (CRSwNP), and evaluate ILC2s across characteristics of the disease.

Methods

Nasal biopsy samples were obtained from normal subjects or subjects with CRSsNP or CRSwNP during surgery. ILC2s were sorted and purified as CD45⁺Lin⁻CD127⁺CD4⁻CD8⁻CRTH2⁺CD161⁺ cells through flow cytometry, and were compared among three groups of subjects. Then, these samples were cultured in vitro, and inflammatory factors were assessed in tissue cultures. After that, human recombinant (rm) interleukin (IL)-33 or IL-17 were administered into the cultures, and we again examined relevant inflammatory substances.

Results

ILC2s were upregulated in neutrophilic CRSsNP and CRSwNP patients, and there were no statistical differences between them. Eosinophil cation protein (ECP), myeloperoxidase (MPO), IL-25, IL-33, IL-5, IL-13, interferon (IFN)-γ and IL-17 were increased in the cultures, however, only concentrations of MPO, IFN-γ and IL-17 were enhanced in CRSwNP tissues compared to CRSsNP ones. After administration of rmIL-33, ECP, IL-5 and IL-13 were all increased in tissues from CRSsNP and CRSwNP patients, however, there were no significant differences between them. Finally, we evaluated concentrations of several above inflammatory factors after the treatment of rmIL-17, and found that MPO and IFN-γ were enhanced in these two phenotypes of patients, and were elevated significantly in CRSwNP tissue cultures.

Conclusion

These findings show that ILC2s might be inactivated in neutrophilic CRSsNP and CRSwNP based on this pilot study.

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Expression of matrix metalloproteinases (MMPs-2, -7, -9, and -26) and tissue inhibitors of metalloproteinases (TIMPs-1 and -2) in pleomorphic adenomas and adenoid cystic carcinomas

Abstract

Purpose

To compare the immunohistochemical expression of matrix metalloproteinases-2, -7, -9 and -26 and tissue inhibitors of metalloproteinases-1 and -2 in pleomorphic adenomas and adenoid cystic carcinomas of the minor salivary glands.

Methods

Twenty cases of pleomorphic adenomas and 20 cases of adenoid cystic carcinomas were evaluated for the immunohistochemical expression of matrix metalloproteinases-2, -7, -9, and -26 and tissue inhibitors-1 and -2 in tumor parenchyma.

Results

Most pleomorphic adenomas and adenoid cystic carcinomas showed high expression of matrix metalloproteinases and tissue inhibitors, predominantly located in the tumor cells. There was no statistically significant difference in the expression of the metalloproteinases-2 (p = 0.359), -7 (p = 0.081), and -26 (p = 0 553), as well as the tissue inhibitors-1 (p = 0.657), and -2 (p = 0.248) between the parenchyma of the studied tumors. Only matrix metalloproteinase-9 showed a significant difference in expression between the two tumors, with adenoid cystic carcinoma showing a more intense staining for this gelatinase (p = 0.041).

Conclusions

The expression of the studied metalloproteinases suggests the involvement of these enzymes in the tissue remodeling process in pleomorphic adenomas and adenoid cystic carcinomas, but only MMP-9, significantly expressed in the adenoid cystic carcinomas, appears to be involved in the process of invasiveness and more aggressive behavior of these tumors. Additionally, results point that TIMPs-1 and -2 may have more complex functions besides metalloproteinase inhibition, which may be related to the pathogenesis and biological behavior of salivary gland tumors.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2DhSD2c

The effect of ectodermal dysplasia on volume and surface area of maxillary sinus

Abstract

Purpose

Ectodermal dysplasia (ED) is a congenital syndrome characterized by abnormal development of ectodermal structures, such as skin, hair, nails, teeth, or salivary glands. Patients with ED demonstrate craniofacial dysmorphology, midfacial hypoplasia and hypodontia. The aim of this study is to evaluate volume and surface area of maxillary sinus and craniofacial structures in patients with ectodermal dysplasia (ED) using cone-beam computed tomography (CBCT) images.

Methods

The CBCT images of 20 patients with ED (study group) and 20 healthy individuals (control) which are equal in terms of age and gender were evaluated. After a three-dimensional analysis and segmentation of each maxillary sinus, the volume and surface area were calculated. Craniofacial dimensions were measured on the sagittal planes of the CBCT images. The results of the ED and control groups were statistically compared.

Results

The right and left sinus volumes and surface areas were significantly lower in the ED group than in the control group (p < 0.05) while the SNA was significantly higher (p < 0.05). ANB and SN-GoMe were also lower in patients with ED than in controls (p < 0.05). The difference in SNB values between the two groups was not significant (p > 0.05).

Conclusions

The volumes and surface areas of both maxillary sinuses were found to be smaller in patients with ED compared to healthy individuals. Class III malocclusion with maxillary retrusion is a characteristic craniofacial feature of these patients.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PX46uN

Evaluation of upper esophageal sphincter in benign vocal lesions

Abstract

Purpose

To evaluate upper esophageal sphincter (UES) activity in patients with benign glottic lesions.

Methods

Twenty-three patients with benign vocal fold (VF) lesions scheduled for manometric evaluation were enrolled as the study group (SG); 20 healthy subjects without vocal pathology or dysphagia were included as the control group (CG). UES residual, basal, relaxation time and peak pharyngeal pressures were evaluated by manometry. The reflux symptom index (RSI) and reflux finding score (RFS) were used to estimate the clinical findings of laryngopharyngeal reflux, and the voice handicap index (VHI) was measured in both groups. The patients' data were compared using the Mann–Whitney test and t test.

Results

The diagnoses in the SG were vocal nodules, vocal polyps, vocal cysts, sulcus vocalis, or Reinke's edema. The evaluation scores (RSI, RFS, and VHI) were significantly higher in the SG than in the CG (P < 0.05). UES basal and relaxation pressures, relaxation time, and peak pharyngeal pressures did not differ between the SG and the CG (P > 0.05).

Conclusion

UES manometric pressure was similar in patients with VF mucosal lesions and controls. Studies involving larger populations are necessary to confirm the manometric changes in the UES and to elucidate the pathogenesis of benign VF lesions.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Dj65mv

Debt, disfigurement place survivors of these types of cancer at higher risk of suicide

Debt, disfigurement place survivors of these types of cancer at higher risk of suicide  St. Louis Public RadioHead And Neck Cancer Treatment Market 2017 – 2021: Analysis, Key Venders, Research, Trends and Segments  TokensTree (press release)Global Head and Neck Cancer Treatment Market 2018-2023 Price, Revenue, Gross Margin, Market Share and ...  Stock AnalysisFull coverage

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2qKxqXi

Debt, disfigurement place survivors of these types of cancer at higher risk of suicide

Debt, disfigurement place survivors of these types of cancer at higher risk of suicide  St. Louis Public RadioHead And Neck Cancer Treatment Market 2017 – 2021: Analysis, Key Venders, Research, Trends and Segments  TokensTree (press release)Global Head and Neck Cancer Treatment Market 2018-2023 Price, Revenue, Gross Margin, Market Share and ...  Stock AnalysisFull coverage

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2qKxqXi

Parents’ received and expected information about their child’s radiation exposure during radiographic examinations

Abstract

Background

Despite regulations, insufficient information is provided to adult patients prior to their radiologic examinations. Information regarding paediatric patients has not been systematically studied.

Objective

To survey parents' experience and wishes for information in connection with their child's radiographic examination.

Materials and methods

We provided a questionnaire to consenting parents of children younger than 12 years old at a university hospital. The questionnaire asked parents about the information obtained from the referrer prior to the radiograph, the chance to discuss with the referrer and their wishes regarding future information. Forty-one parents responded to the survey. Twenty-five children were referred for radiography of extremities, the others for dental, body and skull examinations.

Results

Altogether 34/41 (83%, 95% confidence interval [CI] 69–91%) parents said they received adequate information on the purpose of the examination, 8/35 (23%, 95% CI 12–39%) on other options and 3/41 (7%, 95% CI 3–19%) on radiation dose. Ten of 41 parents (24%, 95% CI 12–40%) said they were aware of radiation exposure. The number of previous radiology examinations was not sufficiently discussed. The communication was scored as mean 6.5 (95% CI 5.8–7.1) on a scale from 4 (poor) to 10 (excellent). Thirty-eight of 40 (95%, 95% CI 84–99%) of parents expected information on the purpose, 35/40 (88%, 95% CI 74–95%) on radiation dose and 31/40 (78%, 95% CI 63–88%) on other options. Symbols of radiation and corresponding period of natural background radiation are preferred to convey the dose. A referrer is the preferred source of information.

Conclusion

Parents did not feel adequately informed prior to their child's radiographic examination. Parents expect more information about the purpose, dose and alternative tests.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2qGbPiE

Parents’ received and expected information about their child’s radiation exposure during radiographic examinations

Abstract

Background

Despite regulations, insufficient information is provided to adult patients prior to their radiologic examinations. Information regarding paediatric patients has not been systematically studied.

Objective

To survey parents' experience and wishes for information in connection with their child's radiographic examination.

Materials and methods

We provided a questionnaire to consenting parents of children younger than 12 years old at a university hospital. The questionnaire asked parents about the information obtained from the referrer prior to the radiograph, the chance to discuss with the referrer and their wishes regarding future information. Forty-one parents responded to the survey. Twenty-five children were referred for radiography of extremities, the others for dental, body and skull examinations.

Results

Altogether 34/41 (83%, 95% confidence interval [CI] 69–91%) parents said they received adequate information on the purpose of the examination, 8/35 (23%, 95% CI 12–39%) on other options and 3/41 (7%, 95% CI 3–19%) on radiation dose. Ten of 41 parents (24%, 95% CI 12–40%) said they were aware of radiation exposure. The number of previous radiology examinations was not sufficiently discussed. The communication was scored as mean 6.5 (95% CI 5.8–7.1) on a scale from 4 (poor) to 10 (excellent). Thirty-eight of 40 (95%, 95% CI 84–99%) of parents expected information on the purpose, 35/40 (88%, 95% CI 74–95%) on radiation dose and 31/40 (78%, 95% CI 63–88%) on other options. Symbols of radiation and corresponding period of natural background radiation are preferred to convey the dose. A referrer is the preferred source of information.

Conclusion

Parents did not feel adequately informed prior to their child's radiographic examination. Parents expect more information about the purpose, dose and alternative tests.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2qGbPiE

Protect your thyroid

Protect your thyroid  dvm360Full coverage

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PqbUG9

Protect your thyroid

Protect your thyroid  dvm360Full coverage

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PqbUG9

Mutated Thyroid Hormone Transporter OATP1C1 Associates with Severe Brain Hypometabolism and Juvenile Neurodegeneration

Thyroid, Volume 28, Issue 11, Page 1406-1415, November 2018.


from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2zRPZx0

Regional Influences on Nutritional Iodine Status of Pregnant Women in Pakistan

Thyroid, Volume 28, Issue 11, Page 1538-1546, November 2018.


from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2zOsp49

Diagnostic Performance of Ultrasound-Based Risk-Stratification Systems for Thyroid Nodules: Comparison of the 2015 American Thyroid Association Guidelines with the 2016 Korean Thyroid Association/Korean Society of Thyroid Radiology and 2017 American Congress of Radiology Guidelines

Thyroid, Volume 28, Issue 11, Page 1532-1537, November 2018.


from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2T7F6Qn

Patients with Oncocytic Variant Papillary Thyroid Carcinoma Have a Similar Prognosis to Matched Classical Papillary Thyroid Carcinoma Controls

Thyroid, Volume 28, Issue 11, Page 1462-1467, November 2018.


from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2zQjjDI

Feasibility of Intraoperative Neuromonitoring During Thyroid Surgery Using Transcartilage Surface Recording Electrodes

Thyroid, Volume 28, Issue 11, Page 1508-1516, November 2018.


from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2TaQWZM

Future Meetings

Thyroid, Volume 28, Issue 11, Page 1559-1560, November 2018.


from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2T21733

Physician Choice of Hypothyroidism Therapy: Influence of Patient Characteristics

Thyroid, Volume 28, Issue 11, Page 1416-1424, November 2018.


from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2zJLmok

Metal Coordinated Poly-Zinc-Liothyronine Provides Stable Circulating Triiodothyronine Levels in Hypothyroid Rats

Thyroid, Volume 28, Issue 11, Page 1425-1433, November 2018.


from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2T9rx30

Regional Influences on Nutritional Iodine Status of Pregnant Women in Pakistan

Thyroid, Volume 28, Issue 11, Page 1538-1546, November 2018.


from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2zOsp49

Diagnostic Performance of Ultrasound-Based Risk-Stratification Systems for Thyroid Nodules: Comparison of the 2015 American Thyroid Association Guidelines with the 2016 Korean Thyroid Association/Korean Society of Thyroid Radiology and 2017 American Congress of Radiology Guidelines

Thyroid, Volume 28, Issue 11, Page 1532-1537, November 2018.


from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2T7F6Qn

Patients with Oncocytic Variant Papillary Thyroid Carcinoma Have a Similar Prognosis to Matched Classical Papillary Thyroid Carcinoma Controls

Thyroid, Volume 28, Issue 11, Page 1462-1467, November 2018.


from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2zQjjDI

Feasibility of Intraoperative Neuromonitoring During Thyroid Surgery Using Transcartilage Surface Recording Electrodes

Thyroid, Volume 28, Issue 11, Page 1508-1516, November 2018.


from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2TaQWZM

Future Meetings

Thyroid, Volume 28, Issue 11, Page 1559-1560, November 2018.


from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2T21733

Physician Choice of Hypothyroidism Therapy: Influence of Patient Characteristics

Thyroid, Volume 28, Issue 11, Page 1416-1424, November 2018.


from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2zJLmok

Metal Coordinated Poly-Zinc-Liothyronine Provides Stable Circulating Triiodothyronine Levels in Hypothyroid Rats

Thyroid, Volume 28, Issue 11, Page 1425-1433, November 2018.


from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2T9rx30

Regional Influences on Nutritional Iodine Status of Pregnant Women in Pakistan

Thyroid, Volume 28, Issue 11, Page 1538-1546, November 2018.


from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2zOsp49

Patients with Oncocytic Variant Papillary Thyroid Carcinoma Have a Similar Prognosis to Matched Classical Papillary Thyroid Carcinoma Controls

Thyroid, Volume 28, Issue 11, Page 1462-1467, November 2018.


from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2zQjjDI

Feasibility of Intraoperative Neuromonitoring During Thyroid Surgery Using Transcartilage Surface Recording Electrodes

Thyroid, Volume 28, Issue 11, Page 1508-1516, November 2018.


from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2TaQWZM

Mutated Thyroid Hormone Transporter OATP1C1 Associates with Severe Brain Hypometabolism and Juvenile Neurodegeneration

Thyroid, Volume 28, Issue 11, Page 1406-1415, November 2018.


from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2zRPZx0

Future Meetings

Thyroid, Volume 28, Issue 11, Page 1559-1560, November 2018.


from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2T21733

Physician Choice of Hypothyroidism Therapy: Influence of Patient Characteristics

Thyroid, Volume 28, Issue 11, Page 1416-1424, November 2018.


from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2zJLmok

Metal Coordinated Poly-Zinc-Liothyronine Provides Stable Circulating Triiodothyronine Levels in Hypothyroid Rats

Thyroid, Volume 28, Issue 11, Page 1425-1433, November 2018.


from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2T9rx30

Regional Influences on Nutritional Iodine Status of Pregnant Women in Pakistan

Thyroid, Volume 28, Issue 11, Page 1538-1546, November 2018.


from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2zOsp49

Diagnostic Performance of Ultrasound-Based Risk-Stratification Systems for Thyroid Nodules: Comparison of the 2015 American Thyroid Association Guidelines with the 2016 Korean Thyroid Association/Korean Society of Thyroid Radiology and 2017 American Congress of Radiology Guidelines

Thyroid, Volume 28, Issue 11, Page 1532-1537, November 2018.


from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2T7F6Qn

Patients with Oncocytic Variant Papillary Thyroid Carcinoma Have a Similar Prognosis to Matched Classical Papillary Thyroid Carcinoma Controls

Thyroid, Volume 28, Issue 11, Page 1462-1467, November 2018.


from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2zQjjDI

Feasibility of Intraoperative Neuromonitoring During Thyroid Surgery Using Transcartilage Surface Recording Electrodes

Thyroid, Volume 28, Issue 11, Page 1508-1516, November 2018.


from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2TaQWZM

Physician Choice of Hypothyroidism Therapy: Influence of Patient Characteristics

Thyroid, Volume 28, Issue 11, Page 1416-1424, November 2018.


from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2QF8Kee

Metal Coordinated Poly-Zinc-Liothyronine Provides Stable Circulating Triiodothyronine Levels in Hypothyroid Rats

Thyroid, Volume 28, Issue 11, Page 1425-1433, November 2018.


from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PpoSUs

Regional Influences on Nutritional Iodine Status of Pregnant Women in Pakistan

Thyroid, Volume 28, Issue 11, Page 1538-1546, November 2018.


from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2QBHNI7

Patients with Oncocytic Variant Papillary Thyroid Carcinoma Have a Similar Prognosis to Matched Classical Papillary Thyroid Carcinoma Controls

Thyroid, Volume 28, Issue 11, Page 1462-1467, November 2018.


from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2QDWhHJ

Feasibility of Intraoperative Neuromonitoring During Thyroid Surgery Using Transcartilage Surface Recording Electrodes

Thyroid, Volume 28, Issue 11, Page 1508-1516, November 2018.


from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Pp8OBX

Dr. Burtness on Findings of KEYNOTE-048 in Head and Neck Cancer

Dr. Burtness on Findings of KEYNOTE-048 in Head and Neck Cancer  OncLiveImmunotherapy improves survival in metastatic or recurrent head and neck cancer  EurekAlert (press release)First-line pembrolizumab a new standard for recurrent, metastatic head and neck squamous cell carcinoma  HealioFull coverage

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2DoT5g0

Mutated Thyroid Hormone Transporter OATP1C1 Associates with Severe Brain Hypometabolism and Juvenile Neurodegeneration

Thyroid, Volume 28, Issue 11, Page 1406-1415, November 2018.


from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2QBHUDx

Future Meetings

Thyroid, Volume 28, Issue 11, Page 1559-1560, November 2018.


from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PpR8Gv

Physician Choice of Hypothyroidism Therapy: Influence of Patient Characteristics

Thyroid, Volume 28, Issue 11, Page 1416-1424, November 2018.


from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2QF8Kee

Feasibility of Intraoperative Neuromonitoring During Thyroid Surgery Using Transcartilage Surface Recording Electrodes

Thyroid, Volume 28, Issue 11, Page 1508-1516, November 2018.


from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Pp8OBX

Dr. Burtness on Findings of KEYNOTE-048 in Head and Neck Cancer

Dr. Burtness on Findings of KEYNOTE-048 in Head and Neck Cancer  OncLiveImmunotherapy improves survival in metastatic or recurrent head and neck cancer  EurekAlert (press release)First-line pembrolizumab a new standard for recurrent, metastatic head and neck squamous cell carcinoma  HealioFull coverage

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2DoT5g0

Massive release of the histamine ‐degrading enzyme diamine oxidase during severe anaphylaxis in mastocytosis patients

ConclusionsDuring severe anaphylaxis in mastocytosis patients DAO is likely released from heparin ‐sensitive gastrointestinal storage sites. The measured concentrations can degrade histamine, but DAO activity is compromised compared to pregnancy samples. For accurate histamine measurements during anaphylaxis DAO inhibition is essential to inhibit further histamine degradation after blood withd rawal. Determination of DAO antigen levels might be of clinical value to improve the diagnosis of mast cell activation.This article is protected by copyright. All rights reserved. (Source: Allergy)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Pq7E9D

The Effect of Delayed and Early Diagnosis in Siblings, and Importance of Newborn Screening for SCID

Severe combined immunodeficiency (SCID) is a form of primary immunodeficiency that affects both cellular and humoral immunity, caused by genetic defects in lymphocyte development and function. There are over 20 known genes mutations that lead to SCID including defects that cause radiosensitivity due to impairment in DNA repair (1). Mutations in DCLREC1 resulting in absent or dysfunctional Artemis protein are the most common cause of SCID associated with increased radiosensitivity and were identified as the etiology of the unusually high incidence of T-B-NK+ SCID in Athabascan-speaking tribes, Apache and Navajo (2,3). (Source: Annals of Allergy, Asthma and Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2QDUYbN

An Ounce of Caution: Superparamagnetic Iron Oxide Nanoparticle Based MRI Contrast Associated Anaphylaxis

Superparamagnetic iron oxide nanoparticles (SPIONs) are increasingly utilized alternatives to gadolinium-based Magnetic Resonance Imaging (MRI) contrast agents in the diagnosis of osteomyelitis in diabetic patients with renal failure [1]. Ferumoxytol is approved by the United States Food and Drug Administration (FDA), the European Medicines Agency, for intravenous (IV) use for iron replacement therapy [1-3]. Ferumoxytol is composed of an iron-carbohydrate complex that minimizes dissociation and appearance of free iron into the serum. (Source: Annals of Allergy, Asthma and Immunology)

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Ppo2ag

Food OIT is Superior to Food Avoidance

Over the last decade much attention has focused on the possibility of using oral immunotherapy (OIT) as a therapeutic approach for treatment of IgE-mediated food allergies, a disease without a Food and Drug Administration (FDA)-approved disease-modifying therapy. Peanut allergy has been a particular concern because of its persistent nature and association with potentially life-threatening reactions. The OIT literature has been criticized for heterogeneity in trial design with disparities in identification of allergic individuals by double blind placebo controlled food challenges (DBPCFC), differences in desensitization approaches and maintenance doses of allergen, absence of a standardized product, inconsistency in the primary endpoint (e.g. (Source: Annals of Allergy, Asthma and Immunolog...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2QDUS3V

Home-Based Treatment with Immunoglobulins: an Evaluation from the Perspective of Patients and Healthcare Professionals

ConclusionsHome-based treatment with immunoglobulins is highly valued because of its personalized and effective character, meeting the needs and preferences of patients. Nonetheless, patients and professionals do have different perspectives on the value of this type of care. (Source: Journal of Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PsZRbb

Markers of atopic dermatitis, allergic rhinitis and bronchial asthma in pediatric patients: correlation with filaggrin, eosinophil major basic protein and immunoglobulin E

Allergic reactions have been implicated as contributions in a number of atopic disorders, including atopic dermatitis (AD), allergic rhinitis (AR) and bronchial asthma (BA). However, the potential for filaggri... (Source: Clinical and Molecular Allergy)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2QIY5ze

Loss of an IgG plasma cell checkpoint in lupus

Using a novel assay for ANA+ plasma cells, we show the presence of a strong tolerance checkpoint. Loss of tolerance in lupus results from expansion of IgG+ plasma cells rather than aberrant antigen-specific selection. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PpQqcj

Germination of pollen grains in the esophagus of individuals with eosinophilic esophagitis

ConclusionAlteration of the mucosal barrier in EoE might cause the penetration of pollen grains into the esophageal tissues. In EoE patients, anatomopathological studies searching for intrusion to plant foods and pollen, and specific ‐guided diet and immunotherapy after plant structures detection in biopsies, might be effective.This article is protected by copyright. All rights reserved. (Source: Clinical and Experimental Allergy)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2QKSrfC

Mast Cell CRF2 Suppresses Mast Cell Degranulation and Limits the Severity of Anaphylaxis and Stress-Induced Intestinal Permeability

Targeting CRF2 and (or) downstream pathways has potential as a new therapeutic approach to limit excessive MC activation and intestinal permeability which initiate and perpetuate highly prevalent and burdensome diseases including allergy, anaphylaxis and functional bowel disorders. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PouUF1

Th9 immunodeficiency in Hyper IgE syndrome patients

(Source: Journal of Allergy and Clinical Immunology)

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Qyqesu

CD3+CD4-CD8- mucosal T cells are associated with uncontrolled chronic rhinosinusitis with nasal polyps

Increased mucosal double-negative (DN) CD3+CD4-CD8- T cells were found for the first time in CRS and were much more abundant in uncontrolled CRSwNP than in well-controlled CRSwNP. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PpyleA

IL4 ‐10 fusion protein: a novel immunoregulatory drug combining activities of interleukin 4 and interleukin 10

The objective of this study was to test the capacity of a newly developed fusion protein of interleukin 4 (IL ‐4) and IL‐10 [IL4‐10 fusion protein (FP)] to shift multiple pro‐inflammatory pathways towards immune regulation, and to inhibit pro‐inflammatory activity in arthritis models. The effects of IL4‐10 FP in comparison with IL‐4, IL‐10 and IL‐4 plus IL‐10 on pro‐ and anti‐inflamm atory mediators, T cells and immunoglobulin (Ig) receptors in favour of immunoregulatory activity were studied. In addition, the capacity of IL4‐10 FP to inhibit pro‐inflammatory activity inex ‐vivo andin ‐vivo arthritis models was investigated. IL4 ‐10 FP robustly inhibited pro‐inflammatory cytokine [IL‐1β, tumour necrosis factor (TNF)‐α, IL‐6 and IL‐8] production...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PpykY4

Massive release of the histamine ‐degrading enzyme diamine oxidase during severe anaphylaxis in mastocytosis patients

ConclusionsDuring severe anaphylaxis in mastocytosis patients DAO is likely released from heparin ‐sensitive gastrointestinal storage sites. The measured concentrations can degrade histamine, but DAO activity is compromised compared to pregnancy samples. For accurate histamine measurements during anaphylaxis DAO inhibition is essential to inhibit further histamine degradation after blood withd rawal. Determination of DAO antigen levels might be of clinical value to improve the diagnosis of mast cell activation.This article is protected by copyright. All rights reserved. (Source: Allergy)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Pq7E9D

The Effect of Delayed and Early Diagnosis in Siblings, and Importance of Newborn Screening for SCID

Severe combined immunodeficiency (SCID) is a form of primary immunodeficiency that affects both cellular and humoral immunity, caused by genetic defects in lymphocyte development and function. There are over 20 known genes mutations that lead to SCID including defects that cause radiosensitivity due to impairment in DNA repair (1). Mutations in DCLREC1 resulting in absent or dysfunctional Artemis protein are the most common cause of SCID associated with increased radiosensitivity and were identified as the etiology of the unusually high incidence of T-B-NK+ SCID in Athabascan-speaking tribes, Apache and Navajo (2,3). (Source: Annals of Allergy, Asthma and Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2QDUYbN

An Ounce of Caution: Superparamagnetic Iron Oxide Nanoparticle Based MRI Contrast Associated Anaphylaxis

Superparamagnetic iron oxide nanoparticles (SPIONs) are increasingly utilized alternatives to gadolinium-based Magnetic Resonance Imaging (MRI) contrast agents in the diagnosis of osteomyelitis in diabetic patients with renal failure [1]. Ferumoxytol is approved by the United States Food and Drug Administration (FDA), the European Medicines Agency, for intravenous (IV) use for iron replacement therapy [1-3]. Ferumoxytol is composed of an iron-carbohydrate complex that minimizes dissociation and appearance of free iron into the serum. (Source: Annals of Allergy, Asthma and Immunology)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Ppo2ag

Food OIT is Superior to Food Avoidance

Over the last decade much attention has focused on the possibility of using oral immunotherapy (OIT) as a therapeutic approach for treatment of IgE-mediated food allergies, a disease without a Food and Drug Administration (FDA)-approved disease-modifying therapy. Peanut allergy has been a particular concern because of its persistent nature and association with potentially life-threatening reactions. The OIT literature has been criticized for heterogeneity in trial design with disparities in identification of allergic individuals by double blind placebo controlled food challenges (DBPCFC), differences in desensitization approaches and maintenance doses of allergen, absence of a standardized product, inconsistency in the primary endpoint (e.g. (Source: Annals of Allergy, Asthma and Immunolog...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2QDUS3V

Home-Based Treatment with Immunoglobulins: an Evaluation from the Perspective of Patients and Healthcare Professionals

ConclusionsHome-based treatment with immunoglobulins is highly valued because of its personalized and effective character, meeting the needs and preferences of patients. Nonetheless, patients and professionals do have different perspectives on the value of this type of care. (Source: Journal of Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PsZRbb

Markers of atopic dermatitis, allergic rhinitis and bronchial asthma in pediatric patients: correlation with filaggrin, eosinophil major basic protein and immunoglobulin E

Allergic reactions have been implicated as contributions in a number of atopic disorders, including atopic dermatitis (AD), allergic rhinitis (AR) and bronchial asthma (BA). However, the potential for filaggri... (Source: Clinical and Molecular Allergy)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2QIY5ze

Loss of an IgG plasma cell checkpoint in lupus

Using a novel assay for ANA+ plasma cells, we show the presence of a strong tolerance checkpoint. Loss of tolerance in lupus results from expansion of IgG+ plasma cells rather than aberrant antigen-specific selection. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PpQqcj

Germination of pollen grains in the esophagus of individuals with eosinophilic esophagitis

ConclusionAlteration of the mucosal barrier in EoE might cause the penetration of pollen grains into the esophageal tissues. In EoE patients, anatomopathological studies searching for intrusion to plant foods and pollen, and specific ‐guided diet and immunotherapy after plant structures detection in biopsies, might be effective.This article is protected by copyright. All rights reserved. (Source: Clinical and Experimental Allergy)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2QKSrfC

CD3+CD4-CD8- mucosal T cells are associated with uncontrolled chronic rhinosinusitis with nasal polyps

Increased mucosal double-negative (DN) CD3+CD4-CD8- T cells were found for the first time in CRS and were much more abundant in uncontrolled CRSwNP than in well-controlled CRSwNP. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PpyleA

Immunomodulatory effects of probiotics: Can they be used to treat allergies and autoimmune diseases?

Regular ingestion of probiotic bacteria, has been used for tapping into the health benefits exerted by microbiota of the gastrointestinal tract (GIT) within a healthy subject. Use of probiotics in the form of fermented milk dates back to ancient times and in Middle Eastern traditions, with claims that Abraham 's longevity was due to the consumption of fermented milk [1,2]. The physiological changes of the GIT and alterations in the gut microbiome associated with age, along with changes in life style and dietary behaviors, leads to changes to the immune system [3]. (Source: Maturitas)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2QDVG8T

IL4 ‐10 fusion protein: a novel immunoregulatory drug combining activities of interleukin 4 and interleukin 10

The objective of this study was to test the capacity of a newly developed fusion protein of interleukin 4 (IL ‐4) and IL‐10 [IL4‐10 fusion protein (FP)] to shift multiple pro‐inflammatory pathways towards immune regulation, and to inhibit pro‐inflammatory activity in arthritis models. The effects of IL4‐10 FP in comparison with IL‐4, IL‐10 and IL‐4 plus IL‐10 on pro‐ and anti‐inflamm atory mediators, T cells and immunoglobulin (Ig) receptors in favour of immunoregulatory activity were studied. In addition, the capacity of IL4‐10 FP to inhibit pro‐inflammatory activity inex ‐vivo andin ‐vivo arthritis models was investigated. IL4 ‐10 FP robustly inhibited pro‐inflammatory cytokine [IL‐1β, tumour necrosis factor (TNF)‐α, IL‐6 and IL‐8] production...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PpykY4

Vestibular Evoked Myographic Correlation

AbstractThis work started from the hypothesis that the physiological processes giving rise to the vestibular evoked myogenic potential (VEMP) can be induced not only by transient sounds but also by a continuous stimulation with a stochastic signal. The hypothesis is based on the idea that the number of motor unit action potentials (MUAPs) decreases after a momentary amplitude increase of the effective stimulus, whereas a momentary amplitude decrease has the opposite effect. This concept was theoretically analyzed by assuming that the effective stimulus is closely related to the envelope of the stimulus actually presented. The analysis led to the prediction that the cross-correlation function of the effective stimulus and the measured electromyogram (EMG) has VEMP-like properties. Experimen...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2RL7ZjQ

Comparison of rim-sparing versus rim-removal techniques in deep lateral wall orbital decompression for Graves ’ orbitopathy

The aim of this study was to compare the surgical outcomes of deep lateral orbital decompression using the rim-sparing technique versus the rim-removal technique in Graves ' orbitopathy (GO). A retrospective cohort study of 75 orbits in 50 patients with GO was performed. Proptosis, best corrected visual acuity (BCVA), intraocular pressure (IOP), upper and lower lid margin to reflex distances (MRD-1 and MRD-2, respectively), diplopia, ocular restriction, and GO quali ty of life (GO-QOL) questionnaire results were analyzed pre- and postoperatively. (Source: International Journal of Oral and Maxillofacial Surgery)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2DzJWBn

Effects of auriculotherapy and midazolam for anxiety control in patients submitted to third molar extraction

Anxiety is common and still represents a barrier to appropriate professional care for patients requiring dental treatment. The aim of this study was to compare the effects of auriculotherapy and midazolam for the control of anxiety in patients submitted to third molar extractions. This was a randomized, double-blind, controlled, crossover clinical trial. Thirty healthy volunteers requiring bilateral third molar extraction received midazolam 15mg (oral) and sham auriculotherapy during one session, and a placebo tablet (oral) and auriculotherapy during the other; the sessions were randomized. (Source: International Journal of Oral and Maxillofacial Surgery)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2RQRgvj

Response to the Letter to the Editor regarding “Impact of crack cocaine use on the occurrence of oral lesions and micronuclei”

We are grateful for the interest in our study "Impact of crack cocaine use on the occurrence of oral lesions and micronuclei"1. Firstly, regarding the criticism that Giemsa stain can cause false-positive results, we agree that this method may provide an overestimate of the presence of micronuclei. However, any misclassification would be non -differential, as a difference in the overestimation between groups is not plausible. Thus, this type of error would bias the results towards the null hypothesis2 and therefore does not account for the differences described in our study between crack users and non-users. (Source: International Journal of Oral and Maxillofacial Surgery)

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Cost analysis of oral and maxillofacial free flap reconstruction for patients at an institution in China

This study was performed to retrospectively analyse the composition of hospitalization expenses and factors influencing this for 507 patients who underwent oral and maxillofacial free flap transplantation at a representative medical institution in China. The aim was to provide evidence for the reasonable control of expenditure and effective utilization of medical resources, and to gain an indirect reflection of the healthcare model characteristics of public hospitals in China. (Source: International Journal of Oral and Maxillofacial Surgery)

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Vestibular Evoked Myographic Correlation

AbstractThis work started from the hypothesis that the physiological processes giving rise to the vestibular evoked myogenic potential (VEMP) can be induced not only by transient sounds but also by a continuous stimulation with a stochastic signal. The hypothesis is based on the idea that the number of motor unit action potentials (MUAPs) decreases after a momentary amplitude increase of the effective stimulus, whereas a momentary amplitude decrease has the opposite effect. This concept was theoretically analyzed by assuming that the effective stimulus is closely related to the envelope of the stimulus actually presented. The analysis led to the prediction that the cross-correlation function of the effective stimulus and the measured electromyogram (EMG) has VEMP-like properties. Experimen...

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Comparison of rim-sparing versus rim-removal techniques in deep lateral wall orbital decompression for Graves ’ orbitopathy

The aim of this study was to compare the surgical outcomes of deep lateral orbital decompression using the rim-sparing technique versus the rim-removal technique in Graves ' orbitopathy (GO). A retrospective cohort study of 75 orbits in 50 patients with GO was performed. Proptosis, best corrected visual acuity (BCVA), intraocular pressure (IOP), upper and lower lid margin to reflex distances (MRD-1 and MRD-2, respectively), diplopia, ocular restriction, and GO quali ty of life (GO-QOL) questionnaire results were analyzed pre- and postoperatively. (Source: International Journal of Oral and Maxillofacial Surgery)

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Effects of auriculotherapy and midazolam for anxiety control in patients submitted to third molar extraction

Anxiety is common and still represents a barrier to appropriate professional care for patients requiring dental treatment. The aim of this study was to compare the effects of auriculotherapy and midazolam for the control of anxiety in patients submitted to third molar extractions. This was a randomized, double-blind, controlled, crossover clinical trial. Thirty healthy volunteers requiring bilateral third molar extraction received midazolam 15mg (oral) and sham auriculotherapy during one session, and a placebo tablet (oral) and auriculotherapy during the other; the sessions were randomized. (Source: International Journal of Oral and Maxillofacial Surgery)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2RQRgvj

Response to the Letter to the Editor regarding “Impact of crack cocaine use on the occurrence of oral lesions and micronuclei”

We are grateful for the interest in our study "Impact of crack cocaine use on the occurrence of oral lesions and micronuclei"1. Firstly, regarding the criticism that Giemsa stain can cause false-positive results, we agree that this method may provide an overestimate of the presence of micronuclei. However, any misclassification would be non -differential, as a difference in the overestimation between groups is not plausible. Thus, this type of error would bias the results towards the null hypothesis2 and therefore does not account for the differences described in our study between crack users and non-users. (Source: International Journal of Oral and Maxillofacial Surgery)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2DBzBor

Cost analysis of oral and maxillofacial free flap reconstruction for patients at an institution in China

This study was performed to retrospectively analyse the composition of hospitalization expenses and factors influencing this for 507 patients who underwent oral and maxillofacial free flap transplantation at a representative medical institution in China. The aim was to provide evidence for the reasonable control of expenditure and effective utilization of medical resources, and to gain an indirect reflection of the healthcare model characteristics of public hospitals in China. (Source: International Journal of Oral and Maxillofacial Surgery)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2RWlUnp

A streamlined pathway for patients with unilateral tinnitus: our experience of 22 patients

ConclusionsThe streamlined unilateral tinnitus patient pathway confers significant benefits to patients, the NHS and wider health economy. Future research should focus on the challenge of scaling and sustaining innovation.This article is protected by copyright. All rights reserved. (Source: Clinical Otolaryngology)

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2T7ZPUa

Cochlear implantation after canal wall down mastoidectomy — Outcomes after partial mastoid obliteration

To describe and evaluate the partial mastoid obliteration of the so-called radical mastoid cavity after canal-wall down mastoidectomy (CWD) for cochlear implantation (CI) compared to overclosure of the external ear canal as two stage procedures. (Source: Auris, Nasus, Larynx)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2zNjY96

A streamlined pathway for patients with unilateral tinnitus: our experience of 22 patients

ConclusionsThe streamlined unilateral tinnitus patient pathway confers significant benefits to patients, the NHS and wider health economy. Future research should focus on the challenge of scaling and sustaining innovation.This article is protected by copyright. All rights reserved. (Source: Clinical Otolaryngology)

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2T7ZPUa

Cochlear implantation after canal wall down mastoidectomy — Outcomes after partial mastoid obliteration

To describe and evaluate the partial mastoid obliteration of the so-called radical mastoid cavity after canal-wall down mastoidectomy (CWD) for cochlear implantation (CI) compared to overclosure of the external ear canal as two stage procedures. (Source: Auris, Nasus, Larynx)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2zNjY96

Debt, disfigurement place survivors of these types of cancer at higher risk of suicide

Debt, disfigurement place survivors of these types of cancer at higher risk of suicide  St. Louis Public RadioFull coverage

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2qKxqXi

Debt, disfigurement place survivors of these types of cancer at higher risk of suicide

Debt, disfigurement place survivors of these types of cancer at higher risk of suicide  St. Louis Public RadioFull coverage

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2qKxqXi

New Study Looks at Selumetinib for Treating Differentiated Thyroid Cancer

New Study Looks at Selumetinib for Treating Differentiated Thyroid Cancer  Cancer NetworkFull coverage

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New Study Looks at Selumetinib for Treating Differentiated Thyroid Cancer

New Study Looks at Selumetinib for Treating Differentiated Thyroid Cancer  Cancer NetworkFull coverage

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Extracorporeal shockwave treatment impedes tooth movement in rats

Accelerated tooth movement has been a topic of interest for orthodontic research recently. Surgically facilitated orthodontic treatment has been shown to be an effective approach to accelerate tooth movement; ...

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Debt, disfigurement place some cancer survivors at higher risk of suicide

Debt, disfigurement place some cancer survivors at higher risk of suicide  St. Louis Public RadioFull coverage

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2qLhaFf

Carotid blowout syndrome: modern trends in management

Carotid blowout syndrome: modern trends in management  Dove Medical PressFull coverage

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Carotid blowout syndrome: modern trends in management

Carotid blowout syndrome: modern trends in management  Dove Medical PressFull coverage

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cDNA cloning, characterization, and expression analysis of the Rac1 and Rac2 genes from Cynoglossus semilaevis

In this study, a Rac1 homolog (CsRac1) and a Rac2 homolog (CsRac2) were cloned from the Cynoglossus semilaevis. The full-length of CsRac1 and CsRac2 cDNA was 1219 bp and 1047 bp, respectively. Both CsRac1 and CsRac2 contain a 579 bp open reading frame (ORF) which encoding a 192 amino acids putative protein. The predicted molecular weight of CsRac1 and CsRac2 was 21.41 kDa and 21.35 kDa, and their theoretical pI was 8.50 and 7.91, respectively. Sequence analysis showed that the conserved RHO domain was detected both from amino acid of CsRac1 and CsRac2. Homologous analysis showed that CsRac1 and CsRac2 share high conservation with other counterparts from different species. The CsRac1 and CsRac2 transcript showed wide tissue distribution, in which CsRac1 and CsRac2 exhibit the highest ex...

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PP5pMv

Effect of dietary L-tryptophan on the survival, immune response and gut microbiota of the Chinese mitten crab, Eriocheir sinensis

This study investigated the influence of L-tryptophan (L-trp) on the survival, immune response and gut microbiota of the Chinese mitten crab, Eriocheir sinensis (with an average weight of 16.58 ± 2.20 g). After 30 days of feeding with diets supplemented with L-trp at 0.36%, 0.47%, 0.73% and 1.05% (groups 1, 2, 3 and 4, respectively), the survival rate and bacterial challenge (Aeromonas hydrophila) were evaluated, the activities of antioxidant and phosphatase enzymes in the serum were assessed, and the gut microbiota were measured via high-throughput Illumina sequencing. The results showed that the supplementation of L-trp significantly improved the survival rate of crabs (P < 0.05). After feeding for 7 days, it was observed that a high L-trp diet significantly increase the s...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2DhC1rk

Production and Function of Different Regions from Mytichitin-1 of Mytilus coruscus

In this study, mytichitin-1 was recombinantly expressed with different lengths, full-length mytichtin-1 (rMchi-F) and the N-terminal region (rMchi-N) in Escherichia coli BL21 with codon optimization. The results of SDS-PAGE, Western blotting, and mass spectrometry confirmed that the two forms of mytichitin-1 had been successfully recombinant expressed with a yield of 40 mg purified enzyme per L culture. In addition, the 55-AA fragment of mytichitin-CB was chemically synthesized (sMchi-CB). After purification and oxidation, the functions of the three protein products were analysed, including chitin degradation, chitin binding, and antimicrobial activities. Both rMchi-F and rMchi-N displayed enzymatic activity with the optimum pH of 4.0 and optimum temperature of 40 °C, and rMchi-N show...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PTzSsv

Anisakiasis: The risks of seafood consumption

Conclusions: Endoscopy was valuable for the diagnosis and treatment of anisakiasis. We recommend endoscopy in suspected cases of anisakiasis. Moreover, it is desirable to combine complementary tests such as immunological tests/IgE measurement. As the popularity of Japanese cuisine increases, reports of anisakiasis are likely to be more frequent in countries other than Japan. (Source: Nigerian Journal of Clinical Practice)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2DgrPzq

cDNA cloning, characterization, and expression analysis of the Rac1 and Rac2 genes from Cynoglossus semilaevis

In this study, a Rac1 homolog (CsRac1) and a Rac2 homolog (CsRac2) were cloned from the Cynoglossus semilaevis. The full-length of CsRac1 and CsRac2 cDNA was 1219 bp and 1047 bp, respectively. Both CsRac1 and CsRac2 contain a 579 bp open reading frame (ORF) which encoding a 192 amino acids putative protein. The predicted molecular weight of CsRac1 and CsRac2 was 21.41 kDa and 21.35 kDa, and their theoretical pI was 8.50 and 7.91, respectively. Sequence analysis showed that the conserved RHO domain was detected both from amino acid of CsRac1 and CsRac2. Homologous analysis showed that CsRac1 and CsRac2 share high conservation with other counterparts from different species. The CsRac1 and CsRac2 transcript showed wide tissue distribution, in which CsRac1 and CsRac2 exhibit the highest ex...

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PP5pMv

Effect of dietary L-tryptophan on the survival, immune response and gut microbiota of the Chinese mitten crab, Eriocheir sinensis

This study investigated the influence of L-tryptophan (L-trp) on the survival, immune response and gut microbiota of the Chinese mitten crab, Eriocheir sinensis (with an average weight of 16.58 ± 2.20 g). After 30 days of feeding with diets supplemented with L-trp at 0.36%, 0.47%, 0.73% and 1.05% (groups 1, 2, 3 and 4, respectively), the survival rate and bacterial challenge (Aeromonas hydrophila) were evaluated, the activities of antioxidant and phosphatase enzymes in the serum were assessed, and the gut microbiota were measured via high-throughput Illumina sequencing. The results showed that the supplementation of L-trp significantly improved the survival rate of crabs (P < 0.05). After feeding for 7 days, it was observed that a high L-trp diet significantly increase the s...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2DhC1rk

Production and Function of Different Regions from Mytichitin-1 of Mytilus coruscus

In this study, mytichitin-1 was recombinantly expressed with different lengths, full-length mytichtin-1 (rMchi-F) and the N-terminal region (rMchi-N) in Escherichia coli BL21 with codon optimization. The results of SDS-PAGE, Western blotting, and mass spectrometry confirmed that the two forms of mytichitin-1 had been successfully recombinant expressed with a yield of 40 mg purified enzyme per L culture. In addition, the 55-AA fragment of mytichitin-CB was chemically synthesized (sMchi-CB). After purification and oxidation, the functions of the three protein products were analysed, including chitin degradation, chitin binding, and antimicrobial activities. Both rMchi-F and rMchi-N displayed enzymatic activity with the optimum pH of 4.0 and optimum temperature of 40 °C, and rMchi-N show...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PTzSsv

Anisakiasis: The risks of seafood consumption

Conclusions: Endoscopy was valuable for the diagnosis and treatment of anisakiasis. We recommend endoscopy in suspected cases of anisakiasis. Moreover, it is desirable to combine complementary tests such as immunological tests/IgE measurement. As the popularity of Japanese cuisine increases, reports of anisakiasis are likely to be more frequent in countries other than Japan. (Source: Nigerian Journal of Clinical Practice)

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EXCLUSIVE: Family Allergy & Asthma acquires largest Louisville competitor, two other offices

The move comes after Family Allergy received an investment from a Chicago-based private-equity firm earlier this year. (Source: bizjournals.com Health Care:Biotechnology headlines)

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2T8kZRV

EXCLUSIVE: Family Allergy & Asthma acquires largest Louisville competitor, two other offices

The move comes after Family Allergy received an investment from a Chicago-based private-equity firm earlier this year. (Source: bizjournals.com Health Care:Biotechnology headlines)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

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Th9 immunodeficiency in Hyper IgE syndrome patients

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2qKpjtO

Mast Cell CRF2 Suppresses Mast Cell Degranulation and Limits the Severity of Anaphylaxis and Stress-Induced Intestinal Permeability

Targeting CRF2 and (or) downstream pathways has potential as a new therapeutic approach to limit excessive MC activation and intestinal permeability which initiate and perpetuate highly prevalent and burdensome diseases including allergy, anaphylaxis and functional bowel disorders.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Fk1Vxm

Loss of an IgG plasma cell checkpoint in lupus

Using a novel assay for ANA+ plasma cells, we show the presence of a strong tolerance checkpoint. Loss of tolerance in lupus results from expansion of IgG+ plasma cells rather than aberrant antigen-specific selection.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2qI5GT3

Shining Sunlight on Industry Payments in Oral and Maxillofacial Surgery: The Sunshine Act

To characterize industry payments to oral and maxillofacial surgeons (OMSs) and to determine the accuracy of the Centers for Medicare & Medicaid Services (CMS) Open Payments Databases.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2B1pN4u

Does apico-coronal implant position influence peri-implant marginal bone loss? A 36-months follow-up randomized clinical trial.

Preserving peri-implant bone and reducing the exposure of rough implant surface might influence long-term outcomes of implant therapy. The aim of this study was to compare peri-implant clinical and radiological parameters after crestal and subcrestal dental implant placement at 36 months of follow-up.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2JXeT2R

Dental and maxillofacial signs in Leri-Weill dyschondrosteosis

One of the most common causes of short stature is a defect of the short stature homeobox-containing (SHOX) gene, which is located in the pseudoautosomal region 1, on the distal end of the short arm of the Xp22.33 and Yp11.32 chromosomes (1). Greater than 300 different mutations in the SHOX gene responsible for short stature syndrome have been described (1,2). The phenotypic expression of SHOX haploinsufficiency is remarkably varied. The following three typical clinical presentations, from least to most severe, are described: idiopathic short stature without skeletal malformations, Leri-Weill dyschondrosteosis (LWD) and Langer mesomelic dysplasia, which is thought to represent the homozygous form of Léri-Weill dyschondrosteosis (3,4).

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2B39tjT

Does apico-coronal implant position influence peri-implant marginal bone loss? A 36-months follow-up randomized clinical trial.

Preserving peri-implant bone and reducing the exposure of rough implant surface might influence long-term outcomes of implant therapy. The aim of this study was to compare peri-implant clinical and radiological parameters after crestal and subcrestal dental implant placement at 36 months of follow-up.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2JXeT2R

Dental and maxillofacial signs in Leri-Weill dyschondrosteosis

One of the most common causes of short stature is a defect of the short stature homeobox-containing (SHOX) gene, which is located in the pseudoautosomal region 1, on the distal end of the short arm of the Xp22.33 and Yp11.32 chromosomes (1). Greater than 300 different mutations in the SHOX gene responsible for short stature syndrome have been described (1,2). The phenotypic expression of SHOX haploinsufficiency is remarkably varied. The following three typical clinical presentations, from least to most severe, are described: idiopathic short stature without skeletal malformations, Leri-Weill dyschondrosteosis (LWD) and Langer mesomelic dysplasia, which is thought to represent the homozygous form of Léri-Weill dyschondrosteosis (3,4).

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2B39tjT

Th9 immunodeficiency in Hyper IgE syndrome patients

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2qKpjtO

Mast Cell CRF2 Suppresses Mast Cell Degranulation and Limits the Severity of Anaphylaxis and Stress-Induced Intestinal Permeability

Targeting CRF2 and (or) downstream pathways has potential as a new therapeutic approach to limit excessive MC activation and intestinal permeability which initiate and perpetuate highly prevalent and burdensome diseases including allergy, anaphylaxis and functional bowel disorders.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Fk1Vxm

Loss of an IgG plasma cell checkpoint in lupus

Using a novel assay for ANA+ plasma cells, we show the presence of a strong tolerance checkpoint. Loss of tolerance in lupus results from expansion of IgG+ plasma cells rather than aberrant antigen-specific selection.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2qI5GT3

Shining Sunlight on Industry Payments in Oral and Maxillofacial Surgery: The Sunshine Act

To characterize industry payments to oral and maxillofacial surgeons (OMSs) and to determine the accuracy of the Centers for Medicare & Medicaid Services (CMS) Open Payments Databases.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2B1pN4u

Does apico-coronal implant position influence peri-implant marginal bone loss? A 36-months follow-up randomized clinical trial.

Preserving peri-implant bone and reducing the exposure of rough implant surface might influence long-term outcomes of implant therapy. The aim of this study was to compare peri-implant clinical and radiological parameters after crestal and subcrestal dental implant placement at 36 months of follow-up.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2JXeT2R

Dental and maxillofacial signs in Leri-Weill dyschondrosteosis

One of the most common causes of short stature is a defect of the short stature homeobox-containing (SHOX) gene, which is located in the pseudoautosomal region 1, on the distal end of the short arm of the Xp22.33 and Yp11.32 chromosomes (1). Greater than 300 different mutations in the SHOX gene responsible for short stature syndrome have been described (1,2). The phenotypic expression of SHOX haploinsufficiency is remarkably varied. The following three typical clinical presentations, from least to most severe, are described: idiopathic short stature without skeletal malformations, Leri-Weill dyschondrosteosis (LWD) and Langer mesomelic dysplasia, which is thought to represent the homozygous form of Léri-Weill dyschondrosteosis (3,4).

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2B39tjT

Shining Sunlight on Industry Payments in Oral and Maxillofacial Surgery: The Sunshine Act

To characterize industry payments to oral and maxillofacial surgeons (OMSs) and to determine the accuracy of the Centers for Medicare & Medicaid Services (CMS) Open Payments Databases.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2B1pN4u

Does apico-coronal implant position influence peri-implant marginal bone loss? A 36-months follow-up randomized clinical trial.

Preserving peri-implant bone and reducing the exposure of rough implant surface might influence long-term outcomes of implant therapy. The aim of this study was to compare peri-implant clinical and radiological parameters after crestal and subcrestal dental implant placement at 36 months of follow-up.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2JXeT2R

Dental and maxillofacial signs in Leri-Weill dyschondrosteosis

One of the most common causes of short stature is a defect of the short stature homeobox-containing (SHOX) gene, which is located in the pseudoautosomal region 1, on the distal end of the short arm of the Xp22.33 and Yp11.32 chromosomes (1). Greater than 300 different mutations in the SHOX gene responsible for short stature syndrome have been described (1,2). The phenotypic expression of SHOX haploinsufficiency is remarkably varied. The following three typical clinical presentations, from least to most severe, are described: idiopathic short stature without skeletal malformations, Leri-Weill dyschondrosteosis (LWD) and Langer mesomelic dysplasia, which is thought to represent the homozygous form of Léri-Weill dyschondrosteosis (3,4).

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2B39tjT

EXCLUSIVE: Family Allergy & Asthma acquires largest Louisville competitor, two other offices

The move comes after Family Allergy received an investment from a Chicago-based private-equity firm earlier this year. (Source: bizjournals.com Health Care:Biotechnology headlines)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2T8kZRV

EXCLUSIVE: Family Allergy & Asthma acquires largest Louisville competitor, two other offices

The move comes after Family Allergy received an investment from a Chicago-based private-equity firm earlier this year. (Source: bizjournals.com Health Care:Biotechnology headlines)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2T8kZRV

Effects of l-carnitine administration on health-related quality of life during cisplatin-based chemoradiotherapy in patients with head and neck squamous cell carcinoma

Cancer-related fatigue impairs daily functioning and negatively impacts health-related quality of life (HRQoL). Our previous study revealed that cisplatin-based chemoradiotherapy (CRT) impairs the carnitine system and carnitine deficiency leads to poor physical functioning. This open label, randomized, controlled prospective study investigated the effects of l-carnitine administration on plasma carnitine concentration, CRT-induced fatigue, and decline in HRQoL in patients with head and neck squamous cell carcinoma (HNSCC).

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Efficacy of anti-PD-1 therapy in a patient with brain metastasis of parotid carcinoma: A case report

CheckMate 141, an open-label, randomized phase III trial of nivolumab, indicated that treatment with nivolumab prolonged overall survival of patients with platinum-refractory, recurrent head and neck squamous cell carcinoma. Herein, we describe a case of brain metastasis of parotid carcinoma in which a good response was achieved after nivolumab treatment. The patient was a 67-year-old woman with parotid carcinoma (cT4bN0M0) who received induction chemotherapy followed by chemoradiation. Computed tomography and magnetic resonance imaging performed 10 weeks after the primary treatment revealed a residual tumor and brain and lung metastases.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2RS2U9A

Cochlear implantation after canal wall down mastoidectomy — Outcomes after partial mastoid obliteration

To describe and evaluate the partial mastoid obliteration of the so-called radical mastoid cavity after canal-wall down mastoidectomy (CWD) for cochlear implantation (CI) compared to overclosure of the external ear canal as two stage procedures.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2DBdSx2

Effects of l-carnitine administration on health-related quality of life during cisplatin-based chemoradiotherapy in patients with head and neck squamous cell carcinoma

Cancer-related fatigue impairs daily functioning and negatively impacts health-related quality of life (HRQoL). Our previous study revealed that cisplatin-based chemoradiotherapy (CRT) impairs the carnitine system and carnitine deficiency leads to poor physical functioning. This open label, randomized, controlled prospective study investigated the effects of l-carnitine administration on plasma carnitine concentration, CRT-induced fatigue, and decline in HRQoL in patients with head and neck squamous cell carcinoma (HNSCC).

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2DBFvGe

Efficacy of anti-PD-1 therapy in a patient with brain metastasis of parotid carcinoma: A case report

CheckMate 141, an open-label, randomized phase III trial of nivolumab, indicated that treatment with nivolumab prolonged overall survival of patients with platinum-refractory, recurrent head and neck squamous cell carcinoma. Herein, we describe a case of brain metastasis of parotid carcinoma in which a good response was achieved after nivolumab treatment. The patient was a 67-year-old woman with parotid carcinoma (cT4bN0M0) who received induction chemotherapy followed by chemoradiation. Computed tomography and magnetic resonance imaging performed 10 weeks after the primary treatment revealed a residual tumor and brain and lung metastases.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2RS2U9A

Cochlear implantation after canal wall down mastoidectomy — Outcomes after partial mastoid obliteration

To describe and evaluate the partial mastoid obliteration of the so-called radical mastoid cavity after canal-wall down mastoidectomy (CWD) for cochlear implantation (CI) compared to overclosure of the external ear canal as two stage procedures.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2DBdSx2

Comparison of rim-sparing versus rim-removal techniques in deep lateral wall orbital decompression for Graves’ orbitopathy

The aim of this study was to compare the surgical outcomes of deep lateral orbital decompression using the rim-sparing technique versus the rim-removal technique in Graves' orbitopathy (GO). A retrospective cohort study of 75 orbits in 50 patients with GO was performed. Proptosis, best corrected visual acuity (BCVA), intraocular pressure (IOP), upper and lower lid margin to reflex distances (MRD-1 and MRD-2, respectively), diplopia, ocular restriction, and GO quality of life (GO-QOL) questionnaire results were analyzed pre- and postoperatively.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2qJ6R4U

Cost analysis of oral and maxillofacial free flap reconstruction for patients at an institution in China

Free flap transplantation has become a mainstay for the restoration of oral and maxillofacial defects. However, the complexity of the surgical procedure and long hospitalization time result in high hospitalization costs. This study was performed to retrospectively analyse the composition of hospitalization expenses and factors influencing this for 507 patients who underwent oral and maxillofacial free flap transplantation at a representative medical institution in China. The aim was to provide evidence for the reasonable control of expenditure and effective utilization of medical resources, and to gain an indirect reflection of the healthcare model characteristics of public hospitals in China.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2FjE2pL

Effects of auriculotherapy and midazolam for anxiety control in patients submitted to third molar extraction

Anxiety is common and still represents a barrier to appropriate professional care for patients requiring dental treatment. The aim of this study was to compare the effects of auriculotherapy and midazolam for the control of anxiety in patients submitted to third molar extractions. This was a randomized, double-blind, controlled, crossover clinical trial. Thirty healthy volunteers requiring bilateral third molar extraction received midazolam 15mg (oral) and sham auriculotherapy during one session, and a placebo tablet (oral) and auriculotherapy during the other; the sessions were randomized.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2qKhDaW

Response to the Letter to the Editor regarding “Impact of crack cocaine use on the occurrence of oral lesions and micronuclei”

We are grateful for the interest in our study "Impact of crack cocaine use on the occurrence of oral lesions and micronuclei"1. Firstly, regarding the criticism that Giemsa stain can cause false-positive results, we agree that this method may provide an overestimate of the presence of micronuclei. However, any misclassification would be non-differential, as a difference in the overestimation between groups is not plausible. Thus, this type of error would bias the results towards the null hypothesis2 and therefore does not account for the differences described in our study between crack users and non-users.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Fgyj3K

Comparison of rim-sparing versus rim-removal techniques in deep lateral wall orbital decompression for Graves’ orbitopathy

The aim of this study was to compare the surgical outcomes of deep lateral orbital decompression using the rim-sparing technique versus the rim-removal technique in Graves' orbitopathy (GO). A retrospective cohort study of 75 orbits in 50 patients with GO was performed. Proptosis, best corrected visual acuity (BCVA), intraocular pressure (IOP), upper and lower lid margin to reflex distances (MRD-1 and MRD-2, respectively), diplopia, ocular restriction, and GO quality of life (GO-QOL) questionnaire results were analyzed pre- and postoperatively.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2qJ6R4U