Massive release of the histamine ‐degrading enzyme diamine oxidase during severe anaphylaxis in mastocytosis patients

ConclusionsDuring severe anaphylaxis in mastocytosis patients DAO is likely released from heparin ‐sensitive gastrointestinal storage sites. The measured concentrations can degrade histamine, but DAO activity is compromised compared to pregnancy samples. For accurate histamine measurements during anaphylaxis DAO inhibition is essential to inhibit further histamine degradation after blood withd rawal. Determination of DAO antigen levels might be of clinical value to improve the diagnosis of mast cell activation.This article is protected by copyright. All rights reserved. (Source: Allergy)

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