Anatomy of the pterygopalatine fossa: an innovative metrical assessment based on 3D segmentation on head CT-scan

Abstract

Purpose

The pterygopalatine fossa is an important anatomical structure for several surgical and anaesthesiologic procedures; yet, very few data are available about its size. This study aims at providing a metrical assessment of pterygopalatine fossa through an innovative 3D segmentation procedure on head CT-scans.

Methods

CT-scans from 100 patients (50 males and 50 females) aged between 18 and 85 years were chosen for the study. Right and left pterygopalatine fossae were segmented through ITK-SNAP open source software. Height and volume were calculated on the acquired 3D models. In addition, anterior–posterior nasal spine distance, upper facial height (nasion–prosthion) and biorbital breadth (ectoconchion–ectoconchion) were measured as well. Statistically significant differences of height and volume according to sex and side were assessed through two-way ANOVA test: sexually dimorphic measurements were further assessed through one-way ANCOVA test using the three cranial measurements as covariates (p < 0.05).

Results

On average pterygopalatine fossa height was 24.1 ± 3.5 mm in males, and 22.8 ± 3.4 mm in females, whereas volume was 0.930 ± 0.181 cm³ in males and 0.817 ± 0.157 cm³ in females, with statistically significant differences according to sex (p < 0.05), but not to side (p > 0.05); interaction was negligible for both the measurements. ANCOVA test verified that sexual dimorphism of both measurements is independent from general cranial size (p < 0.05).

Conclusions

The present study highlighted the sexual dimorphism of pterygopalatine fossa: results may improve the knowledge of this anatomical structure difficult to explore, but crucial in several fields of clinics and surgery.

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Anatomy of the pterygopalatine fossa: an innovative metrical assessment based on 3D segmentation on head CT-scan

Abstract

Purpose

The pterygopalatine fossa is an important anatomical structure for several surgical and anaesthesiologic procedures; yet, very few data are available about its size. This study aims at providing a metrical assessment of pterygopalatine fossa through an innovative 3D segmentation procedure on head CT-scans.

Methods

CT-scans from 100 patients (50 males and 50 females) aged between 18 and 85 years were chosen for the study. Right and left pterygopalatine fossae were segmented through ITK-SNAP open source software. Height and volume were calculated on the acquired 3D models. In addition, anterior–posterior nasal spine distance, upper facial height (nasion–prosthion) and biorbital breadth (ectoconchion–ectoconchion) were measured as well. Statistically significant differences of height and volume according to sex and side were assessed through two-way ANOVA test: sexually dimorphic measurements were further assessed through one-way ANCOVA test using the three cranial measurements as covariates (p < 0.05).

Results

On average pterygopalatine fossa height was 24.1 ± 3.5 mm in males, and 22.8 ± 3.4 mm in females, whereas volume was 0.930 ± 0.181 cm³ in males and 0.817 ± 0.157 cm³ in females, with statistically significant differences according to sex (p < 0.05), but not to side (p > 0.05); interaction was negligible for both the measurements. ANCOVA test verified that sexual dimorphism of both measurements is independent from general cranial size (p < 0.05).

Conclusions

The present study highlighted the sexual dimorphism of pterygopalatine fossa: results may improve the knowledge of this anatomical structure difficult to explore, but crucial in several fields of clinics and surgery.

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Michigan businesses are discharging contaminants into water - The Telegraph

Michigan businesses are discharging contaminants into water  The Telegraph

A newspaper investigation has found that Michigan businesses are discharging large amounts of chemical contaminants into the state's waterways every day.

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Revised American Thyroid Association Guidelines for the Management of Medullary Thyroid Carcinoma - AAP News

Revised American Thyroid Association Guidelines for the Management of Medullary Thyroid Carcinoma  AAP News

In May 2015, the American Academy of Pediatrics endorsed the following publication: Wells SA Jr, Asa SL, Dralle H, et al; The American Thyroid Association ...

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Michigan businesses are discharging contaminants into water - The Telegraph

Michigan businesses are discharging contaminants into water  The Telegraph

A newspaper investigation has found that Michigan businesses are discharging large amounts of chemical contaminants into the state's waterways every day.

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Revised American Thyroid Association Guidelines for the Management of Medullary Thyroid Carcinoma - AAP News

Revised American Thyroid Association Guidelines for the Management of Medullary Thyroid Carcinoma  AAP News

In May 2015, the American Academy of Pediatrics endorsed the following publication: Wells SA Jr, Asa SL, Dralle H, et al; The American Thyroid Association ...

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Respiratory Care Devices Market All Set To Perceive Massive Gains by Most Demanding Industry Players up to 2023 | Confirms MRFR - Press Release - Digital Journal

Respiratory Care Devices Market All Set To Perceive Massive Gains by Most Demanding Industry Players up to 2023 | Confirms MRFR - Press Release  Digital Journal

"Market Research Future"Global Respiratory Care Devices Market: Therapeutic devices (PAP Devices), Monitoring devices (Pulse Oximeters), Diagnostic ...

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Vaccinated with a Phonograph Needle - Brooklyn Rail

Vaccinated with a Phonograph Needle  Brooklyn Rail

There's this guy. He's pretty normal looking, just your average mid-century white Texan male in a probably un-ironed white dress shirt and slacks, possibly a lab ...

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Vaccinated with a Phonograph Needle - Brooklyn Rail

Vaccinated with a Phonograph Needle  Brooklyn Rail

There's this guy. He's pretty normal looking, just your average mid-century white Texan male in a probably un-ironed white dress shirt and slacks, possibly a lab ...

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Respiratory Care Devices Market All Set To Perceive Massive Gains by Most Demanding Industry Players up to 2023 | Confirms MRFR - Press Release - Digital Journal

Respiratory Care Devices Market All Set To Perceive Massive Gains by Most Demanding Industry Players up to 2023 | Confirms MRFR - Press Release  Digital Journal

"Market Research Future"Global Respiratory Care Devices Market: Therapeutic devices (PAP Devices), Monitoring devices (Pulse Oximeters), Diagnostic ...

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Correction to: Anatomical locations in the oral cavity where surgical resections of oral squamous cell carcinomas are associated with a close or positive margin—a retrospective study

The following note was inadvertently omitted from the published paper: This work was performed in (partial) fulfillment of the requirements for the first author's obtaining the degree Dr. med. dent.

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Correction to: Anatomical locations in the oral cavity where surgical resections of oral squamous cell carcinomas are associated with a close or positive margin—a retrospective study

The following note was inadvertently omitted from the published paper: This work was performed in (partial) fulfillment of the requirements for the first author's obtaining the degree Dr. med. dent.

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Individual synaptic vesicles mediate stimulated exocytosis from cochlear inner hair cells [Neuroscience]

Spontaneous excitatory postsynaptic currents (sEPSCs) measured from the first synapse in the mammalian auditory pathway reach a large mean amplitude with a high level of variance (CV between 0.3 and 1). This has led some to propose that each inner hair cell (IHC) ribbon-type active zone (AZ), on average, releases... (Source: Proceedings of the National Academy of Sciences)

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Maternally inherited diabetes and deafness complicated by mesangial galactose-deficient IgA1 deposits: a case report

Maternally inherited diabetes and deafness (MIDD), a mitochondrial genetic disorder, typically affects the kidneys and results in end-stage renal disease. Early diagnosis of MIDD is challenging when renal mani... (Source: BMC Nephrology)

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Maternally inherited diabetes and deafness complicated by mesangial galactose-deficient IgA1 deposits: a case report

Maternally inherited diabetes and deafness (MIDD), a mitochondrial genetic disorder, typically affects the kidneys and results in end-stage renal disease. Early diagnosis of MIDD is challenging when renal mani... (Source: BMC Nephrology)

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Individual synaptic vesicles mediate stimulated exocytosis from cochlear inner hair cells [Neuroscience]

Spontaneous excitatory postsynaptic currents (sEPSCs) measured from the first synapse in the mammalian auditory pathway reach a large mean amplitude with a high level of variance (CV between 0.3 and 1). This has led some to propose that each inner hair cell (IHC) ribbon-type active zone (AZ), on average, releases... (Source: Proceedings of the National Academy of Sciences)

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Profile of Akiko Iwasaki [Profiles]

Akiko Iwasaki, an immunologist at the Yale School of Medicine and a Howard Hughes Medical Institute Investigator, has made significant contributions toward understanding innate and adaptive immunity. Her achievements include the demonstration of tissue-specific properties of dendritic cells (DCs), discovery of a pathway by which immune responses to viruses can... (Source: Proceedings of the National Academy of Sciences)

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Mizzou is marshaling its forces against cancer - News - Columbia Daily Tribune

Mizzou is marshaling its forces against cancer - News  Columbia Daily Tribune

The University of Missouri is well known for its role in educating the state's workforce and its connections to businesses and communities across Missouri, but ...

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Early and late outcomes of bevacizumab plus chemotherapy versus chemot | OTT - Dove Medical Press

Early and late outcomes of bevacizumab plus chemotherapy versus chemot | OTT  Dove Medical Press

Early and late outcomes of bevacizumab plus chemotherapy versus chemotherapy alone as a neoadjuvant treatment in HER2-negative nonmetastatic breast ...

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Vernal Keratoconjunctivitis

Vernal keratoconjunctivitis, a chronic, bilateral, seasonal allergic inflammatory disease of the eye, is an important cause of visual debilitation and impairment of quality of life in children and young adults in certain parts of the world such as the Mediterranean areas, Central and West Africa, the Middle East, Japan, the Indian subcontinent, and South America. It usually has a self-limiting course; however, in a few cases the disease is recurrent and leads to long-term visual disabling complications like keratoconus and limbal stem cell deficiency. (Source: Survey of Ophthalmology)

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ERVmap analysis reveals genome-wide transcription of human endogenous retroviruses [Immunology and Inflammation]

Endogenous retroviruses (ERVs) are integrated retroviral elements that make up 8% of the human genome. However, the impact of ERVs on human health and disease is not well understood. While select ERVs have been implicated in diseases, including autoimmune disease and cancer, the lack of tools to analyze genome-wide, locus-specific... (Source: Proceedings of the National Academy of Sciences)

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CD226 regulates natural killer cell antitumor responses via phosphorylation-mediated inactivation of transcription factor FOXO1 [Immunology and Inflammation]

Natural killer (NK) cell recognition of tumor cells is mediated through activating receptors such as CD226, with suppression of effector functions often controlled by negative regulatory transcription factors such as FOXO1. Here we show that CD226 regulation of NK cell cytotoxicity is facilitated through inactivation of FOXO1. Gene-expression analysis of... (Source: Proceedings of the National Academy of Sciences)

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Molecular mechanisms of biogenesis of apoptotic exosome-like vesicles and their roles as damage-associated molecular patterns [Immunology and Inflammation]

Recent research has led to contradictory notions regarding the conventional theory that apoptotic cell death can evoke inflammatory or immunogenic responses orchestrated by released damage-associated patterns (DAMPs). By inducing IL-1β from bone marrow-derived macrophages in an effort to determine the inflammatory mediators released from apoptotic cells, we found that exosomal... (Source: Proceedings of the National Academy of Sciences)

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A case series of cementless revision total knee arthroplasty in patients with benzoyl peroxide allergy

ConclusionsThe regression of complaints after replacement with cementless and nickel-free revision implants suggests allergic implant intolerance. Implantation of a cementless, hypoallergenic endoprosthesis might, therefore, be a surgical treatment strategy in patients with evidence of allergies. (Source: International Orthopaedics)

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Precise tracking of vaccine-responding T cell clones reveals convergent and personalized response in identical twins [Immunology and Inflammation]

T cell receptor (TCR) repertoire data contain information about infections that could be used in disease diagnostics and vaccine development, but extracting that information remains a major challenge. Here we developed a statistical framework to detect TCR clone proliferation and contraction from longitudinal repertoire data. We applied this framework to... (Source: Proceedings of the National Academy of Sciences)

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The NRL Podcast: News and views on the greatest game of all - NRL.COM

The NRL Podcast: News and views on the greatest game of all  NRL.COM

The NRL Podcast takes you behind the scenes with some of the biggest names in the game, delving into the issues on and off the field in the Telstra ...

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Mizzou is marshaling its forces against cancer - News - Columbia Daily Tribune

Mizzou is marshaling its forces against cancer - News  Columbia Daily Tribune

The University of Missouri is well known for its role in educating the state's workforce and its connections to businesses and communities across Missouri, but ...

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Molecular mechanisms of biogenesis of apoptotic exosome-like vesicles and their roles as damage-associated molecular patterns [Immunology and Inflammation]

Recent research has led to contradictory notions regarding the conventional theory that apoptotic cell death can evoke inflammatory or immunogenic responses orchestrated by released damage-associated patterns (DAMPs). By inducing IL-1β from bone marrow-derived macrophages in an effort to determine the inflammatory mediators released from apoptotic cells, we found that exosomal... (Source: Proceedings of the National Academy of Sciences)

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ERVmap analysis reveals genome-wide transcription of human endogenous retroviruses [Immunology and Inflammation]

Endogenous retroviruses (ERVs) are integrated retroviral elements that make up 8% of the human genome. However, the impact of ERVs on human health and disease is not well understood. While select ERVs have been implicated in diseases, including autoimmune disease and cancer, the lack of tools to analyze genome-wide, locus-specific... (Source: Proceedings of the National Academy of Sciences)

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Precise tracking of vaccine-responding T cell clones reveals convergent and personalized response in identical twins [Immunology and Inflammation]

T cell receptor (TCR) repertoire data contain information about infections that could be used in disease diagnostics and vaccine development, but extracting that information remains a major challenge. Here we developed a statistical framework to detect TCR clone proliferation and contraction from longitudinal repertoire data. We applied this framework to... (Source: Proceedings of the National Academy of Sciences)

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A case series of cementless revision total knee arthroplasty in patients with benzoyl peroxide allergy

ConclusionsThe regression of complaints after replacement with cementless and nickel-free revision implants suggests allergic implant intolerance. Implantation of a cementless, hypoallergenic endoprosthesis might, therefore, be a surgical treatment strategy in patients with evidence of allergies. (Source: International Orthopaedics)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2C54Oyv

CD226 regulates natural killer cell antitumor responses via phosphorylation-mediated inactivation of transcription factor FOXO1 [Immunology and Inflammation]

Natural killer (NK) cell recognition of tumor cells is mediated through activating receptors such as CD226, with suppression of effector functions often controlled by negative regulatory transcription factors such as FOXO1. Here we show that CD226 regulation of NK cell cytotoxicity is facilitated through inactivation of FOXO1. Gene-expression analysis of... (Source: Proceedings of the National Academy of Sciences)

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The NRL Podcast: News and views on the greatest game of all - NRL.COM

The NRL Podcast: News and views on the greatest game of all  NRL.COM

The NRL Podcast takes you behind the scenes with some of the biggest names in the game, delving into the issues on and off the field in the Telstra ...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Ga1ENX

Profile of Akiko Iwasaki [Profiles]

Akiko Iwasaki, an immunologist at the Yale School of Medicine and a Howard Hughes Medical Institute Investigator, has made significant contributions toward understanding innate and adaptive immunity. Her achievements include the demonstration of tissue-specific properties of dendritic cells (DCs), discovery of a pathway by which immune responses to viruses can... (Source: Proceedings of the National Academy of Sciences)

MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.

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Vernal Keratoconjunctivitis

Vernal keratoconjunctivitis, a chronic, bilateral, seasonal allergic inflammatory disease of the eye, is an important cause of visual debilitation and impairment of quality of life in children and young adults in certain parts of the world such as the Mediterranean areas, Central and West Africa, the Middle East, Japan, the Indian subcontinent, and South America. It usually has a self-limiting course; however, in a few cases the disease is recurrent and leads to long-term visual disabling complications like keratoconus and limbal stem cell deficiency. (Source: Survey of Ophthalmology)

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Early and late outcomes of bevacizumab plus chemotherapy versus chemot | OTT - Dove Medical Press

Early and late outcomes of bevacizumab plus chemotherapy versus chemot | OTT  Dove Medical Press

Early and late outcomes of bevacizumab plus chemotherapy versus chemotherapy alone as a neoadjuvant treatment in HER2-negative nonmetastatic breast ...

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Tobacco 21 — its time has come

Source: vtdigger.org Author: Nevin Zablotsky, DMD As we approach the holiday season I am reminded of the gifts of love we […]

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Tobacco 21 — its time has come

Source: vtdigger.org Author: Nevin Zablotsky, DMD As we approach the holiday season I am reminded of the gifts of love we […]

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Tobacco 21 — its time has come

Source: vtdigger.org Author: Nevin Zablotsky, DMD As we approach the holiday season I am reminded of the gifts of love we […]

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Tobacco 21 — its time has come

Source: vtdigger.org Author: Nevin Zablotsky, DMD As we approach the holiday season I am reminded of the gifts of love we […]

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Global Silent Cancer Therapeutic Market to Offer Increased Growth Prospects for Manufacturers - LANews By Abhishek Budholiya

Global Silent Cancer Therapeutic Market to Offer Increased Growth Prospects for Manufacturers  LANews By Abhishek Budholiya

Silent cancer refers to those types of cancer which are undiagnosed in early stages. This is due to asymptomatic nature of the disease which makes it difficult to ...

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Global Silent Cancer Therapeutic Market to Offer Increased Growth Prospects for Manufacturers - LANews By Abhishek Budholiya

Global Silent Cancer Therapeutic Market to Offer Increased Growth Prospects for Manufacturers  LANews By Abhishek Budholiya

Silent cancer refers to those types of cancer which are undiagnosed in early stages. This is due to asymptomatic nature of the disease which makes it difficult to ...

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Contrasting Novocure (NVCR) & Interpace Diagnostics Group (IDXG) - Baseball Daily News

Contrasting Novocure (NVCR) & Interpace Diagnostics Group (IDXG)  Baseball Daily News

Novocure (NASDAQ:NVCR) and Interpace Diagnostics Group (NASDAQ:IDXG) are both medical companies, but which is the superior business? We will ...

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Million-dollar homes and a battle against cancer: What court papers reveal about Huawei's jailed CFO - WTVA

Million-dollar homes and a battle against cancer: What court papers reveal about Huawei's jailed CFO  WTVA

The arrest of Huawei's chief financial officer has thrust her into the middle of a diplomatic storm and is e...

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Million-dollar homes and a battle against cancer: What court papers reveal about Huawei's jailed CFO - WTVA

Million-dollar homes and a battle against cancer: What court papers reveal about Huawei's jailed CFO  WTVA

The arrest of Huawei's chief financial officer has thrust her into the middle of a diplomatic storm and is e...

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Contrasting Novocure (NVCR) & Interpace Diagnostics Group (IDXG) - Baseball Daily News

Contrasting Novocure (NVCR) & Interpace Diagnostics Group (IDXG)  Baseball Daily News

Novocure (NASDAQ:NVCR) and Interpace Diagnostics Group (NASDAQ:IDXG) are both medical companies, but which is the superior business? We will ...

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Incidental findings on 18-FDG PET–CT in head and neck cancer | European Archives of Oto-Rhino-Laryngology - MD Linx

Incidental findings on 18-FDG PET–CT in head and neck cancer | European Archives of Oto-Rhino-Laryngology  MD Linx

In patients with head and neck cancer undergoing staging or surveillance of disease, experts evaluated the rate of 'incidental' findings resulting from 18-FDG ...

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Incidental findings on 18-FDG PET–CT in head and neck cancer | European Archives of Oto-Rhino-Laryngology - MD Linx

Incidental findings on 18-FDG PET–CT in head and neck cancer | European Archives of Oto-Rhino-Laryngology  MD Linx

In patients with head and neck cancer undergoing staging or surveillance of disease, experts evaluated the rate of 'incidental' findings resulting from 18-FDG ...

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Photocatalytic reduction and scavenging of Hg(II) over templated-dewetted Au on TiO2 nanotubes

Photochem. Photobiol. Sci., 2019, Advance Article
DOI: 10.1039/C8PP00424B, Paper

Davide Spanu, Alessandro Bestetti, Helga Hildebrand, Patrik Schmuki, Marco Altomare, Sandro Recchia
Au nanoparticles over TiO₂ nanotubes strongly promote photocatalytic reduction/scavenging of Hg(II) through the formation of Hg₂Cl₂ nanowires (or Au–Hg amalgams).
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

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Sodium nitrite potentiates antimicrobial photodynamic inactivation: possible involvement of peroxynitrate

Photochem. Photobiol. Sci., 2019, Advance Article
DOI: 10.1039/C8PP00452H, Paper

Ying-Ying Huang, Paweł J. Rajda, Grzegorz Szewczyk, Brijesh Bhayana, Long Y. Chiang, Tadeusz Sarna, Michael R. Hamblin
Antimicrobial photodynamic inactivation using different photosensitizers of Gram-positive and Gram-negative bacteria can be potentiated up to one million times by addition of sodium nitrite. The mechanism is proposed to involve formation of peroxynitrate.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

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Tobacco 21 — its time has come

Source: vtdigger.org Author: Nevin Zablotsky, DMD As we approach the holiday season I am reminded of the gifts of love we […]

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2EhEGSz

Photocatalytic reduction and scavenging of Hg(II) over templated-dewetted Au on TiO2 nanotubes

Photochem. Photobiol. Sci., 2019, Advance Article
DOI: 10.1039/C8PP00424B, Paper

Davide Spanu, Alessandro Bestetti, Helga Hildebrand, Patrik Schmuki, Marco Altomare, Sandro Recchia
Au nanoparticles over TiO₂ nanotubes strongly promote photocatalytic reduction/scavenging of Hg(II) through the formation of Hg₂Cl₂ nanowires (or Au–Hg amalgams).
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2C5hGEI

Sodium nitrite potentiates antimicrobial photodynamic inactivation: possible involvement of peroxynitrate

Photochem. Photobiol. Sci., 2019, Advance Article
DOI: 10.1039/C8PP00452H, Paper

Ying-Ying Huang, Paweł J. Rajda, Grzegorz Szewczyk, Brijesh Bhayana, Long Y. Chiang, Tadeusz Sarna, Michael R. Hamblin
Antimicrobial photodynamic inactivation using different photosensitizers of Gram-positive and Gram-negative bacteria can be potentiated up to one million times by addition of sodium nitrite. The mechanism is proposed to involve formation of peroxynitrate.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry

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Tobacco 21 — its time has come

Source: vtdigger.org Author: Nevin Zablotsky, DMD As we approach the holiday season I am reminded of the gifts of love we […]

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Stellenwert der Sialendoskopie an deutschen HNO-Kliniken im Jahr 2016

Laryngo-Rhino-Otol
DOI: 10.1055/a-0805-5846

Hintergrund Eine Umfrage aus dem Jahr 2009 zeigte, dass lediglich etwa 24 % aller deutschen HNO-Kliniken die Sialendoskopie anboten. Durch die Wiederholung der Untersuchung im Jahr 2016 sollte die Entwicklung der Sialendoskopie an deutschen HNO-Kliniken reevaluiert werden. Material und Methoden Erneut wurde ein selbstentwickelter Fragebogen mit elf Fragen an alle deutschen HNO-Kliniken verschickt. Der gleiche Fragebogen wurde bereits im Jahr 2009 verwendet. Die aktuellen Umfrageergebnisse wurden mit den Ergebnissen von damals verglichen und ausgewertet. Ergebnisse Die Zahl der sialendoskopierenden HNO-Kliniken konnte sich mehr als verdoppeln. Die Anzahl der Interventionen verdreifachte sich. Die Gründe dafür, dass eine Klinik keine Sialendoskopien durchführte, waren verschieden. Ein Hauptargument war ein Mangel an Patienten. Kaum Veränderungen ergaben sich bei ambulanten und stationären Therapien und der Eingriffsdauer. Die Sonographie wird unverändert von allen Kliniken präoperativ durchgeführt. Schlussfolgerung Auffallend ist, dass bei zunehmender Anzahl an Kliniken, die die Sialendoskopie anbieten und steigenden Fallzahlen, ein Teil der Kliniken einen Patientenmangel angibt. Dies könnte für die Etablierung von spezialisierten Zentren sprechen. Inzwischen werden neben der obstruktiven Sialadenitis weitere Krankheitsbilder durch die Sialendoskopie therapiert. Die Sonographie bleibt die präoperative Diagnostik der Wahl. Die Auswertung zeigt, dass die Sialendoskopie in den vergangenen sieben Jahren eine steigende Akzeptanz an deutschen HNO-Kliniken erfahren hat.
[...]

© Georg Thieme Verlag KG Stuttgart · New York

Article in Thieme eJournals:
Table of contents  |  Abstract  |  Full text

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Stellenwert der Sialendoskopie an deutschen HNO-Kliniken im Jahr 2016

Laryngo-Rhino-Otol
DOI: 10.1055/a-0805-5846

Hintergrund Eine Umfrage aus dem Jahr 2009 zeigte, dass lediglich etwa 24 % aller deutschen HNO-Kliniken die Sialendoskopie anboten. Durch die Wiederholung der Untersuchung im Jahr 2016 sollte die Entwicklung der Sialendoskopie an deutschen HNO-Kliniken reevaluiert werden. Material und Methoden Erneut wurde ein selbstentwickelter Fragebogen mit elf Fragen an alle deutschen HNO-Kliniken verschickt. Der gleiche Fragebogen wurde bereits im Jahr 2009 verwendet. Die aktuellen Umfrageergebnisse wurden mit den Ergebnissen von damals verglichen und ausgewertet. Ergebnisse Die Zahl der sialendoskopierenden HNO-Kliniken konnte sich mehr als verdoppeln. Die Anzahl der Interventionen verdreifachte sich. Die Gründe dafür, dass eine Klinik keine Sialendoskopien durchführte, waren verschieden. Ein Hauptargument war ein Mangel an Patienten. Kaum Veränderungen ergaben sich bei ambulanten und stationären Therapien und der Eingriffsdauer. Die Sonographie wird unverändert von allen Kliniken präoperativ durchgeführt. Schlussfolgerung Auffallend ist, dass bei zunehmender Anzahl an Kliniken, die die Sialendoskopie anbieten und steigenden Fallzahlen, ein Teil der Kliniken einen Patientenmangel angibt. Dies könnte für die Etablierung von spezialisierten Zentren sprechen. Inzwischen werden neben der obstruktiven Sialadenitis weitere Krankheitsbilder durch die Sialendoskopie therapiert. Die Sonographie bleibt die präoperative Diagnostik der Wahl. Die Auswertung zeigt, dass die Sialendoskopie in den vergangenen sieben Jahren eine steigende Akzeptanz an deutschen HNO-Kliniken erfahren hat.
[...]

© Georg Thieme Verlag KG Stuttgart · New York

Article in Thieme eJournals:
Table of contents  |  Abstract  |  Full text

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Loews Has Upped Stake in Western Digital (WDC); Longwood Capital Partners Cut Stake in Veracyte (VCYT) as Share Value Rose - D Minute

Loews Has Upped Stake in Western Digital (WDC); Longwood Capital Partners Cut Stake in Veracyte (VCYT) as Share Value Rose  D Minute

Loews Corp increased its stake in Western Digital Corp (WDC) by 64.09% based on its latest 2018Q3 regulatory filing with the SEC. Loews Corp bought 141000 ...

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Characterization of normal-appearing white matter in multiple sclerosis using quantitative susceptibility mapping in conjunction with diffusion tensor imaging

Abstract

Purpose

Quantitative susceptibility mapping (QSM) is influenced by iron as well as myelin, which makes interpretation of pathologic changes challenging. Concurrent acquisition of MR sequences that are sensitive to axonal/myelin integrity, such as diffusion tensor imaging (DTI), may provide context for interpreting quantitative susceptibility (QS) signal. The purpose of our study was to investigate alterations in normal-appearing white matter (NAWM) in multiple sclerosis (MS) using QSM in conjunction with DTI.

Methods

Twenty relapsing–remitting MS patients and 20 age-matched healthy controls (HC) were recruited for this prospective study. QS, radial diffusivity (RD), fractional anisotropy (FA), and R2* maps within the whole brain as well as individual tracts were generated for comparison between NAWM and HC white matter (HCWM).

Results

MS lesions demonstrated significant differences in QS, FA, RD, and R2* compared to HCWM (p < 0.03). These metrics did not show a significant difference between whole-brain NAWM and HCWM. Among NAWM tracts, the cingulate gyri demonstrated significantly decreased QS compared to HCWM (p = 0.004). The forceps major showed significant differences in FA and RD without corresponding changes in QS (p < 0.01).

Conclusion

We found discordant changes in QSM and DTI metrics within the cingulate gyri and forceps major. This may potentially reflect the influence of paramagnetic substrates such as iron, which could be decreased along these NAWM tracts. Our results point to the potential role of QSM as a unique biomarker, although additional validation studies are needed.

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Drug Is 'Game Changer'; Screen Cancer Patients for TRK Fusion - Medscape

Drug Is 'Game Changer'; Screen Cancer Patients for TRK Fusion  Medscape

The new drug larotrectinib is a precision medicine 'game changer.' Cancer patients should be screened for TRK fusion to find potential responders, clinicians ...

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Characterization of normal-appearing white matter in multiple sclerosis using quantitative susceptibility mapping in conjunction with diffusion tensor imaging

Abstract

Purpose

Quantitative susceptibility mapping (QSM) is influenced by iron as well as myelin, which makes interpretation of pathologic changes challenging. Concurrent acquisition of MR sequences that are sensitive to axonal/myelin integrity, such as diffusion tensor imaging (DTI), may provide context for interpreting quantitative susceptibility (QS) signal. The purpose of our study was to investigate alterations in normal-appearing white matter (NAWM) in multiple sclerosis (MS) using QSM in conjunction with DTI.

Methods

Twenty relapsing–remitting MS patients and 20 age-matched healthy controls (HC) were recruited for this prospective study. QS, radial diffusivity (RD), fractional anisotropy (FA), and R2* maps within the whole brain as well as individual tracts were generated for comparison between NAWM and HC white matter (HCWM).

Results

MS lesions demonstrated significant differences in QS, FA, RD, and R2* compared to HCWM (p < 0.03). These metrics did not show a significant difference between whole-brain NAWM and HCWM. Among NAWM tracts, the cingulate gyri demonstrated significantly decreased QS compared to HCWM (p = 0.004). The forceps major showed significant differences in FA and RD without corresponding changes in QS (p < 0.01).

Conclusion

We found discordant changes in QSM and DTI metrics within the cingulate gyri and forceps major. This may potentially reflect the influence of paramagnetic substrates such as iron, which could be decreased along these NAWM tracts. Our results point to the potential role of QSM as a unique biomarker, although additional validation studies are needed.

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Loews Has Upped Stake in Western Digital (WDC); Longwood Capital Partners Cut Stake in Veracyte (VCYT) as Share Value Rose - D Minute

Loews Has Upped Stake in Western Digital (WDC); Longwood Capital Partners Cut Stake in Veracyte (VCYT) as Share Value Rose  D Minute

Loews Corp increased its stake in Western Digital Corp (WDC) by 64.09% based on its latest 2018Q3 regulatory filing with the SEC. Loews Corp bought 141000 ...

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Drug Is 'Game Changer'; Screen Cancer Patients for TRK Fusion - Medscape

Drug Is 'Game Changer'; Screen Cancer Patients for TRK Fusion  Medscape

The new drug larotrectinib is a precision medicine 'game changer.' Cancer patients should be screened for TRK fusion to find potential responders, clinicians ...

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Information for Readers

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Editorial Board

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Table of Contents

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Society Page

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Table of Contents

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Information for Readers

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Acknowledgement of Reviewers 2018

The editors of Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology thank the following reviewers and editorial board members for their dedication and time-consuming work on behalf of the journal for manuscripts submitted during the period from July 1, 2017 through June 30, 2018. They have provided rigorous peer review of submissions necessary to ensure that readers of the journal receive sound and reliable information.

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Society Page

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Pregabalin's effect on radiotherapy-related neuropathic pain | Journal of Clinical Oncology - MD Linx

Pregabalin's effect on radiotherapy-related neuropathic pain | Journal of Clinical Oncology  MD Linx

Internal Medicine Article: Effect of pregabalin on radiotherapy-related neuropathic pain in patients with head and neck cancer: A randomized controlled trial.

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Cellectar Biosciences (CLRB) Secures Patent in Japan for CLR 131 - StreetInsider.com

Cellectar Biosciences (CLRB) Secures Patent in Japan for CLR 131  StreetInsider.com

Cellectar Biosciences, Inc. (NASDAQ: CLRB) announces that the Japan Patent Office has granted the patent titled "Phospholipid Analogs as Diapeutic Agents ...

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Novel enzyme that fuels lung tumor growth could be 'perfect' drug target - MD Linx

Novel enzyme that fuels lung tumor growth could be 'perfect' drug target  MD Linx

Cutting off fuel to a tumor-building enzyme could be a new therapeutic strategy against lung cancer.

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NIH to fund HIV care and prevention research in vulnerable southern US communities

(NIH/National Institute of Allergy and Infectious Diseases) The National Institute of Allergy and Infectious Diseases will fund a series of collaborations with medical research institutions in the southern United States to test new ways of implementing HIV treatment and prevention tools in counties with some of the highest rates of new HIV cases nationwide. The US South overall has the highest rates of new HIV diagnoses, people living with HIV, and HIV-related deaths of any US region. (Source: EurekAlert! - Infectious and Emerging Diseases)

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Novel enzyme that fuels lung tumor growth could be 'perfect' drug target - MD Linx

Novel enzyme that fuels lung tumor growth could be 'perfect' drug target  MD Linx

Cutting off fuel to a tumor-building enzyme could be a new therapeutic strategy against lung cancer.

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Pregabalin's effect on radiotherapy-related neuropathic pain | Journal of Clinical Oncology - MD Linx

Pregabalin's effect on radiotherapy-related neuropathic pain | Journal of Clinical Oncology  MD Linx

Internal Medicine Article: Effect of pregabalin on radiotherapy-related neuropathic pain in patients with head and neck cancer: A randomized controlled trial.

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Manslaughter Charge in Flint; Baby Allergy Over-Dx; the Blues in Rural Texas

(MedPage Today) -- This past week in healthcare investigations (Source: MedPage Today Allergy)

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NIH to fund HIV care and prevention research in vulnerable southern US communities

(NIH/National Institute of Allergy and Infectious Diseases) The National Institute of Allergy and Infectious Diseases will fund a series of collaborations with medical research institutions in the southern United States to test new ways of implementing HIV treatment and prevention tools in counties with some of the highest rates of new HIV cases nationwide. The US South overall has the highest rates of new HIV diagnoses, people living with HIV, and HIV-related deaths of any US region. (Source: EurekAlert! - Infectious and Emerging Diseases)

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Media registration open for ENDO 2019 - Newswise

Media registration open for ENDO 2019  Newswise

Members of the media can now register to cover the latest advances in hormone health and science at ENDO 2019. The Endocrine Society's annual meeting will ...

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Manslaughter Charge in Flint; Baby Allergy Over-Dx; the Blues in Rural Texas

(MedPage Today) -- This past week in healthcare investigations (Source: MedPage Today Allergy)

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NIH to fund HIV care and prevention research in vulnerable southern US communities

(NIH/National Institute of Allergy and Infectious Diseases) The National Institute of Allergy and Infectious Diseases will fund a series of collaborations with medical research institutions in the southern United States to test new ways of implementing HIV treatment and prevention tools in counties with some of the highest rates of new HIV cases nationwide. The US South overall has the highest rates of new HIV diagnoses, people living with HIV, and HIV-related deaths of any US region. (Source: EurekAlert! - Infectious and Emerging Diseases)

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Manslaughter Charge in Flint; Baby Allergy Over-Dx; the Blues in Rural Texas

(MedPage Today) -- This past week in healthcare investigations (Source: MedPage Today Allergy)

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Manslaughter Charge in Flint; Baby Allergy Over-Dx; the Blues in Rural Texas

(MedPage Today) -- This past week in healthcare investigations (Source: MedPage Today Allergy)

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Manslaughter Charge in Flint; Baby Allergy Over-Dx; the Blues in Rural Texas

(MedPage Today) -- This past week in healthcare investigations (Source: MedPage Today Allergy)

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NIH to fund HIV care and prevention research in vulnerable southern US communities

(NIH/National Institute of Allergy and Infectious Diseases) The National Institute of Allergy and Infectious Diseases will fund a series of collaborations with medical research institutions in the southern United States to test new ways of implementing HIV treatment and prevention tools in counties with some of the highest rates of new HIV cases nationwide. The US South overall has the highest rates of new HIV diagnoses, people living with HIV, and HIV-related deaths of any US region. (Source: EurekAlert! - Infectious and Emerging Diseases)

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Management of abnormal deep inferior epigastric vessels in microsurgical breast reconstruction: a report of 3 complex cases

Abstract

The deep inferior epigastric artery perforator flap is the gold standard in microsurgical breast reconstruction. It is now increasingly offered in patients with previous abdominal scars and in such cases, computed tomography angiography (CTA) is routinely implemented. However, previous injury of the deep inferior epigastric vessels may be difficult to detect with CTA. We report three cases of successful bilateral breast reconstruction, in which a unilateral DIEA was found to be abnormal. In the first two cases, the unilateral DIE vessels were found to be damaged and the flaps salvaged based on the deep superior epigastric artery. In the third patient, previous DIEA injury resulted in vessel recanalization, which was only evident following initial anastomotic failure. In this case, the damaged DIEA segment was subsequently removed and the flap successfully revascularized. All three patients had an uneventful post-operative recovery and all flaps survived with no complications. Based on our experience, we believe that awareness of the potential pitfalls and careful planning for lifeboats are essential to avoid flap loss in such circumstances.

Level of Evidence: Level V, therapeutic study.

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Simultaneous Loss of Both Atypical Protein Kinase C Genes in the Intestinal Epithelium Drives Serrated Intestinal Cancer by Impairing Immunosurveillance

Serrated adenocarcinomas are an aggressive and treatment-resistant form of colorectal cancer. Nakanishi et  al. show that expression of atypical PKCs is reduced in human serrated tumors and that their loss results in spontaneous serrated tumorigenesis with stromal activation and immunosuppression in mice. The simultaneous inhibition of stromal activation combined with anti-PD-L1 showed synergistic thera peutic potential. (Source: Immunity)

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Cytokine levels in crevicular fluid associated with compliance during periodontal maintenance therapy

ConclusionsThe inflammatory cytokines IL-1, TNF- α, IL-6, and MMP-8 were correlated with worse clinical parameters among IC, while IL-10 was associated with an improvement in clinical parameters among RC. These results reinforce the role of these cytokines in the pathogenesis of periodontitis, as well as their role as markers to monitoring the pr ogression of the periodontitis.Clinical relevanceRegular compliance during 6-year period the PMT sustained clinical and immunological benefits obtained after active periodontal therapy. (Source: Clinical Oral Investigations)

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KILchip v1.0: A Novel Plasmodium falciparum Merozoite Protein Microarray to Facilitate Malaria Vaccine Candidate Prioritization

Gathoni Kamuyu, James Tuju, Rinter Kimathi, Kennedy Mwai, James Mburu, Nelson Kibinge, Marisa Chong Kwan, Sam Hawkings, Reuben Yaa, Emily Chepsat, James M. Njunge, Timothy Chege, Fatuma Guleid, Micha Rosenkranz, Christopher K. Kariuki, Roland Frank, Samson M. Kinyanjui, Linda M. Murungi, Philip Bejon, Anna F ärnert, Kevin K. A. Tetteh, James G. Beeson, David J. Conway, Kevin Marsh, Julian C. Rayner, Faith H. A. Osier (Source: Frontiers in Immunology)

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The Asthma Controller Step-down Yardstick

Guidelines for asthma recommend a series of treatment steps (Figure 1) as a framework for disease management.1,2 The steps allow individualized adjustments in controller therapy in an upward or downward manner in response to a patient 's level of asthma control over a period of time. For patients with inadequately controlled asthma, a step-up is recommended.1,2 Strategies for stepping up controller therapy are described in detail in the adult and pediatric Asthma Yardsticks.3,4 For patients whose asthma has been well controlled for at least 3 months (or longer for the highest risk patients), controller treatment may be stepped down. (Source: Annals of Allergy, Asthma and Immunology)

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NMDAR encephalitis presenting as akinesia in a patient with Parkinson disease

We describe the case of a woman with Parkinson disease who developed an N-methyl-d-aspartate receptor antibody-mediated encephalitis. As a novelty, the encephalitis presentation mimicked a worsening of the pre-existing extrapyramidal syndrome, manifesting mainly as severe bradykinesia and, eventually, akinesia. MRI brain was normal, whereas cerebrospinal fluid (CSF) analysis disclosed unique-to-CSF oligoclonal bands. Prompt identification and timely immunotherapy led to a complete recovery. (Source: Journal of Neuroimmunology)

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Successful Anti-PD-1 Cancer Immunotherapy Requires T Cell-Dendritic Cell Crosstalk Involving the Cytokines IFN- γ and IL-12

Anti-PD-1 mAbs can induce sustained clinical responses in cancer but how they function in  vivo remains incompletely understood. Garris et al. show that effective anti-PD-1 immunotherapy requires intratumoral dendritic cells (DCs) producing IL-12. Anti-PD-1 indirectly activates DCs through IFN-γ released from drug-activated T cells. Furthermore, agonizing the non-canonical NF-κB pat hway activates DCs and enhances aPD-1 therapy in an IL-12-dependent manner. (Source: Immunity)

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Salmonella Persist in Activated Macrophages in T Cell-Sparse Granulomas but Are Contained by Surrounding CXCR3 Ligand-Positioned Th1 Cells

The pathogen Salmonella enterica (Se) can paradoxically persist in hosts while being controlled by IFN- γ-producing Th1 cells. Goldberg et al. show that the bacteria survive by resisting the effects of toxic host molecules in myeloid cells within granulomas, in areas lacking T cells. Infection is constrained by Th1 cells positioned around the granuloma via the CXCR3-CXCL9/10 chemokine axis. (Source: Immunity)

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The role of the skin microbiome in atopic dermatitis

Atopic dermatitis (AD) is a common inflammatory skin disease associated with significant medical burden, affecting 15-20% of children and 1-3% of adults worldwide.1 The prevalence of AD has increased by 2-3 folds during the past decade in Western countries. While the cause of this increase remains unknown, meta-analyses have indicated that the risk of AD is lower when associated with potentially protective environmental factors during childhood such as three or more siblings, day care, pet ownership and farm residence. (Source: Annals of Allergy, Asthma and Immunology)

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Microbiota-Induced TNF-like Ligand 1A Drives Group 3 Innate Lymphoid Cell-Mediated Barrier Protection and Intestinal T Cell Activation during Colitis

Inflammatory bowel disease (IBD) results from a dysregulated interaction between the microbiota and a genetically susceptible host. Castellanos et  al. show a protective role for microbial induction of the IBD-linked protein TL1A in promoting ILC3 barrier immunity and uncover a pathogenic role for TL1A-induced expression of OX40L on ILC3s in driving chronic T cell colitis. (Source: Immunity)

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Inference of the HIV-1 VRC01 Antibody Lineage Unmutated Common Ancestor Reveals Alternative Pathways to Overcome a Key Glycan Barrier

Understanding how HIV-1 VRC01-class broadly neutralizing antibodies overcome maturation barriers is key for vaccine development. Bonsignori et  al. inferred the unmutated common ancestor of the VRC01 lineage, reconstructed the stages of lineage maturation, and identified multiple solutions adopted by evolving B cells to overcome the N276 glycan barrier and achieve broad neutralization. (Source: Immunity)

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KILchip v1.0: A Novel Plasmodium falciparum Merozoite Protein Microarray to Facilitate Malaria Vaccine Candidate Prioritization

Gathoni Kamuyu, James Tuju, Rinter Kimathi, Kennedy Mwai, James Mburu, Nelson Kibinge, Marisa Chong Kwan, Sam Hawkings, Reuben Yaa, Emily Chepsat, James M. Njunge, Timothy Chege, Fatuma Guleid, Micha Rosenkranz, Christopher K. Kariuki, Roland Frank, Samson M. Kinyanjui, Linda M. Murungi, Philip Bejon, Anna F ärnert, Kevin K. A. Tetteh, James G. Beeson, David J. Conway, Kevin Marsh, Julian C. Rayner, Faith H. A. Osier (Source: Frontiers in Immunology)

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Inference of the HIV-1 VRC01 Antibody Lineage Unmutated Common Ancestor Reveals Alternative Pathways to Overcome a Key Glycan Barrier

Understanding how HIV-1 VRC01-class broadly neutralizing antibodies overcome maturation barriers is key for vaccine development. Bonsignori et  al. inferred the unmutated common ancestor of the VRC01 lineage, reconstructed the stages of lineage maturation, and identified multiple solutions adopted by evolving B cells to overcome the N276 glycan barrier and achieve broad neutralization. (Source: Immunity)

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Simultaneous Loss of Both Atypical Protein Kinase C Genes in the Intestinal Epithelium Drives Serrated Intestinal Cancer by Impairing Immunosurveillance

Serrated adenocarcinomas are an aggressive and treatment-resistant form of colorectal cancer. Nakanishi et  al. show that expression of atypical PKCs is reduced in human serrated tumors and that their loss results in spontaneous serrated tumorigenesis with stromal activation and immunosuppression in mice. The simultaneous inhibition of stromal activation combined with anti-PD-L1 showed synergistic thera peutic potential. (Source: Immunity)

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The role of the skin microbiome in atopic dermatitis

Atopic dermatitis (AD) is a common inflammatory skin disease associated with significant medical burden, affecting 15-20% of children and 1-3% of adults worldwide.1 The prevalence of AD has increased by 2-3 folds during the past decade in Western countries. While the cause of this increase remains unknown, meta-analyses have indicated that the risk of AD is lower when associated with potentially protective environmental factors during childhood such as three or more siblings, day care, pet ownership and farm residence. (Source: Annals of Allergy, Asthma and Immunology)

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Management of abnormal deep inferior epigastric vessels in microsurgical breast reconstruction: a report of 3 complex cases

Abstract

The deep inferior epigastric artery perforator flap is the gold standard in microsurgical breast reconstruction. It is now increasingly offered in patients with previous abdominal scars and in such cases, computed tomography angiography (CTA) is routinely implemented. However, previous injury of the deep inferior epigastric vessels may be difficult to detect with CTA. We report three cases of successful bilateral breast reconstruction, in which a unilateral DIEA was found to be abnormal. In the first two cases, the unilateral DIE vessels were found to be damaged and the flaps salvaged based on the deep superior epigastric artery. In the third patient, previous DIEA injury resulted in vessel recanalization, which was only evident following initial anastomotic failure. In this case, the damaged DIEA segment was subsequently removed and the flap successfully revascularized. All three patients had an uneventful post-operative recovery and all flaps survived with no complications. Based on our experience, we believe that awareness of the potential pitfalls and careful planning for lifeboats are essential to avoid flap loss in such circumstances.

Level of Evidence: Level V, therapeutic study.

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Cytokine levels in crevicular fluid associated with compliance during periodontal maintenance therapy

ConclusionsThe inflammatory cytokines IL-1, TNF- α, IL-6, and MMP-8 were correlated with worse clinical parameters among IC, while IL-10 was associated with an improvement in clinical parameters among RC. These results reinforce the role of these cytokines in the pathogenesis of periodontitis, as well as their role as markers to monitoring the pr ogression of the periodontitis.Clinical relevanceRegular compliance during 6-year period the PMT sustained clinical and immunological benefits obtained after active periodontal therapy. (Source: Clinical Oral Investigations)

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The Asthma Controller Step-down Yardstick

Guidelines for asthma recommend a series of treatment steps (Figure 1) as a framework for disease management.1,2 The steps allow individualized adjustments in controller therapy in an upward or downward manner in response to a patient 's level of asthma control over a period of time. For patients with inadequately controlled asthma, a step-up is recommended.1,2 Strategies for stepping up controller therapy are described in detail in the adult and pediatric Asthma Yardsticks.3,4 For patients whose asthma has been well controlled for at least 3 months (or longer for the highest risk patients), controller treatment may be stepped down. (Source: Annals of Allergy, Asthma and Immunology)

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Successful Anti-PD-1 Cancer Immunotherapy Requires T Cell-Dendritic Cell Crosstalk Involving the Cytokines IFN- γ and IL-12

Anti-PD-1 mAbs can induce sustained clinical responses in cancer but how they function in  vivo remains incompletely understood. Garris et al. show that effective anti-PD-1 immunotherapy requires intratumoral dendritic cells (DCs) producing IL-12. Anti-PD-1 indirectly activates DCs through IFN-γ released from drug-activated T cells. Furthermore, agonizing the non-canonical NF-κB pat hway activates DCs and enhances aPD-1 therapy in an IL-12-dependent manner. (Source: Immunity)

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Vaccine-Induced Protection from Homologous Tier 2 SHIV Challenge in Nonhuman Primates Depends on Serum-Neutralizing Antibody Titers

Vaccine-induced immunity to HIV is a major research focus, but relevant correlates of protection remain controversial. Here, Pauthner et  al. study protection from hard-to-neutralize SHIVBG505 challenge after immunization with native-like BG505 Envelope trimers in nonhuman primates and identify neutralizing antibodies, but not T cell or ADCC activity, as correlates of protection. (Source: Immunity)

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Salmonella Persist in Activated Macrophages in T Cell-Sparse Granulomas but Are Contained by Surrounding CXCR3 Ligand-Positioned Th1 Cells

The pathogen Salmonella enterica (Se) can paradoxically persist in hosts while being controlled by IFN- γ-producing Th1 cells. Goldberg et al. show that the bacteria survive by resisting the effects of toxic host molecules in myeloid cells within granulomas, in areas lacking T cells. Infection is constrained by Th1 cells positioned around the granuloma via the CXCR3-CXCL9/10 chemokine axis. (Source: Immunity)

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Microbiota-Induced TNF-like Ligand 1A Drives Group 3 Innate Lymphoid Cell-Mediated Barrier Protection and Intestinal T Cell Activation during Colitis

Inflammatory bowel disease (IBD) results from a dysregulated interaction between the microbiota and a genetically susceptible host. Castellanos et  al. show a protective role for microbial induction of the IBD-linked protein TL1A in promoting ILC3 barrier immunity and uncover a pathogenic role for TL1A-induced expression of OX40L on ILC3s in driving chronic T cell colitis. (Source: Immunity)

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Re: Overdiagnosis and industry influence: how cow ’s milk protein allergy is extending the reach of infant formula manufacturers

(Source: BMJ Comments)

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Management of abnormal deep inferior epigastric vessels in microsurgical breast reconstruction: a report of 3 complex cases

Abstract

The deep inferior epigastric artery perforator flap is the gold standard in microsurgical breast reconstruction. It is now increasingly offered in patients with previous abdominal scars and in such cases, computed tomography angiography (CTA) is routinely implemented. However, previous injury of the deep inferior epigastric vessels may be difficult to detect with CTA. We report three cases of successful bilateral breast reconstruction, in which a unilateral DIEA was found to be abnormal. In the first two cases, the unilateral DIE vessels were found to be damaged and the flaps salvaged based on the deep superior epigastric artery. In the third patient, previous DIEA injury resulted in vessel recanalization, which was only evident following initial anastomotic failure. In this case, the damaged DIEA segment was subsequently removed and the flap successfully revascularized. All three patients had an uneventful post-operative recovery and all flaps survived with no complications. Based on our experience, we believe that awareness of the potential pitfalls and careful planning for lifeboats are essential to avoid flap loss in such circumstances.

Level of Evidence: Level V, therapeutic study.

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Re: Overdiagnosis and industry influence: how cow ’s milk protein allergy is extending the reach of infant formula manufacturers

(Source: BMJ Comments)

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2UBEwLd

Management of abnormal deep inferior epigastric vessels in microsurgical breast reconstruction: a report of 3 complex cases

Abstract

The deep inferior epigastric artery perforator flap is the gold standard in microsurgical breast reconstruction. It is now increasingly offered in patients with previous abdominal scars and in such cases, computed tomography angiography (CTA) is routinely implemented. However, previous injury of the deep inferior epigastric vessels may be difficult to detect with CTA. We report three cases of successful bilateral breast reconstruction, in which a unilateral DIEA was found to be abnormal. In the first two cases, the unilateral DIE vessels were found to be damaged and the flaps salvaged based on the deep superior epigastric artery. In the third patient, previous DIEA injury resulted in vessel recanalization, which was only evident following initial anastomotic failure. In this case, the damaged DIEA segment was subsequently removed and the flap successfully revascularized. All three patients had an uneventful post-operative recovery and all flaps survived with no complications. Based on our experience, we believe that awareness of the potential pitfalls and careful planning for lifeboats are essential to avoid flap loss in such circumstances.

Level of Evidence: Level V, therapeutic study.

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Siglec-8 in eosinophilic disorders: receptor expression and targeting using chimeric antibodies

Siglec-8 levels are similar on blood eosinophils irrespective of eosinophil count or disease activity. Anti-Siglec-8 antibodies induce death of eosinophils from eosinophilic donors in vitro and in a humanized mouse model of IL-5-driven eosinophilia. (Source: Journal of Allergy and Clinical Immunology)

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Siglec-8 in eosinophilic disorders: receptor expression and targeting using chimeric antibodies

Siglec-8 levels are similar on blood eosinophils irrespective of eosinophil count or disease activity. Anti-Siglec-8 antibodies induce death of eosinophils from eosinophilic donors in vitro and in a humanized mouse model of IL-5-driven eosinophilia. (Source: Journal of Allergy and Clinical Immunology)

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Billi Mucklow in terrifying cancer scare as she has secret surgery to remove tumour from her neck - The Irish Sun

Billi Mucklow in terrifying cancer scare as she has secret surgery to remove tumour from her neck  The Irish Sun

The former Towie star has since been giving the all clear after suffering five weeks of hell.

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China slams 'inhumane' treatment of Huawei executive - Channel NewsAsia

China slams 'inhumane' treatment of Huawei executive  Channel NewsAsia

FILE PHOTO: A man holds a sign outside of the B.C. Supreme Court bail hearing of Huawei CFO Meng Wanzhou, who is being held on an extradition warrant in ...

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Billi Mucklow in terrifying cancer scare as she has secret surgery to remove tumour from her neck - The Irish Sun

Billi Mucklow in terrifying cancer scare as she has secret surgery to remove tumour from her neck  The Irish Sun

The former Towie star has since been giving the all clear after suffering five weeks of hell.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2A3CjzV

China slams 'inhumane' treatment of Huawei executive - Channel NewsAsia

China slams 'inhumane' treatment of Huawei executive  Channel NewsAsia

FILE PHOTO: A man holds a sign outside of the B.C. Supreme Court bail hearing of Huawei CFO Meng Wanzhou, who is being held on an extradition warrant in ...

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Interpace Diagnostics Group Inc (IDXG) Given Average Recommendation of “Buy” by Brokerages - Baseball Daily News

Interpace Diagnostics Group Inc (IDXG) Given Average Recommendation of "Buy" by Brokerages  Baseball Daily News

Interpace Diagnostics Group Inc (NASDAQ:IDXG) has earned a consensus rating of "Buy" from the seven brokerages that are covering the firm, Marketbeat.com ...

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'Quiet Man' asks for donations to 'Lary's' group - The Beverly Review

'Quiet Man' asks for donations to 'Lary's' group  The Beverly Review

Many people know me as the former president of the Maple Morgan Park Community Food Pantry.

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'Quiet Man' asks for donations to 'Lary's' group - The Beverly Review

'Quiet Man' asks for donations to 'Lary's' group  The Beverly Review

Many people know me as the former president of the Maple Morgan Park Community Food Pantry.

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The NIH Says It Will Spend Up to $20 Million to Find Alternatives to Human Fetal Tissue

The National Institutes of Health (NIH) announced Monday that it will soon embark on a major research effort to find scientific alternatives to human fetal tissue, a switch that may affect research ranging from basic science to drug trials. Human fetal tissue is commonly used by scientists to mimic human biology in order to understand normal development, study the effects of disease or test drugs. Its use in research is legal but fiercely opposed by some pro-life activists, given that it is procured after elective abortions. Over the next two years, the NIH will supply up to $20 million for research that seeks to "develop and/or further refine human tissue models that closely mimic and can be used to faithfully model human embryonic development or other aspects of human biology, for ...

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The NIH Says It Will Spend Up to $20 Million to Find Alternatives to Human Fetal Tissue

The National Institutes of Health (NIH) announced Monday that it will soon embark on a major research effort to find scientific alternatives to human fetal tissue, a switch that may affect research ranging from basic science to drug trials. Human fetal tissue is commonly used by scientists to mimic human biology in order to understand normal development, study the effects of disease or test drugs. Its use in research is legal but fiercely opposed by some pro-life activists, given that it is procured after elective abortions. Over the next two years, the NIH will supply up to $20 million for research that seeks to "develop and/or further refine human tissue models that closely mimic and can be used to faithfully model human embryonic development or other aspects of human biology, for ...

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2L9H1Ac

Incorporating Oral and Maxillofacial Surgeons on Facial Allotransplantation Teams

Facial allotransplantation was introduced over a decade ago in France as an innovative means to restore appearance and function in patients with severe facial disfigurement resulting from high-energy avulsive incidents. Safety and feasibility were shown in several centers worldwide, and ethical and psychological barriers have been overcome. Facial transplantation evolved to include the entire face, both jaws and tongue as reported by Dorafshar et al (1). A standardized treatment algorithm based on classification of injury was developed due to wide variability across institutions performing transplantation (2).

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PAlaCR

The NIH Says It Will Spend Up to $20 Million to Find Alternatives to Human Fetal Tissue

The National Institutes of Health (NIH) announced Monday that it will soon embark on a major research effort to find scientific alternatives to human fetal tissue, a switch that may affect research ranging from basic science to drug trials. Human fetal tissue is commonly used by scientists to mimic human biology in order to understand normal development, study the effects of disease or test drugs. Its use in research is legal but fiercely opposed by some pro-life activists, given that it is procured after elective abortions. Over the next two years, the NIH will supply up to $20 million for research that seeks to "develop and/or further refine human tissue models that closely mimic and can be used to faithfully model human embryonic development or other aspects of human biology, for ...

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2L9H1Ac

Septic arthritis of the temporomandibular joint in a 10 year old: a case report and literature review.

Septic arthritis of the temporomandibular joint (TMJ) is extremely rare in the paediatric population, with only 9 cases reported in English literature. We report a case of septic TMJ in a 10-year-old female and review the literature for diagnostic criteria and management strategies.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2zVZI60

The effect of one-suture and suture-less techniques on post-operative healing following third molar surgery.

Wound closure technique for lower third molar surgery (LTMS) is an operative factor that influences wound healing and early post-operative complications. This study investigates two closure techniques; partial closure using one suture and the suture-less technique, after using a modified buccal envelope flap for LTMS.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PxijKT

Imaging of the temporomandibular joint in juvenile idiopathic arthritis: How does quantitative compare to semi-quantitative MRI scoring?

Contrast-enhanced MRI is commonly used to evaluate temporomandibular joint (TMJ) disease in patients with juvenile idiopathic arthritis (JIA). However, MRI assessment is limited by qualitative reporting, presence of enhancement in normal joints, and lack of standardized protocols. The purpose of this study is to compare a quantitative MRI analysis, enhancement ratio (ER), to a new semi-quantitative system developed by OMERACT (Outcome Measures in Rheumatology and Clinical Trials).

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Effects of Direct Oral Anticoagulants on Quality of Life during Peri-procedural Management for Dental Extractions

Direct oral anticoagulants (DOACs) have many advantages over warfarin regarding the peri-procedural management for dental extractions. They avoid the need to assess and possibly adjust warfarin therapy to achieve an appropriate hemostatic status before and after extraction. This study aimed to evaluate the real-life data regarding quality of life (QoL) and burden for patients with atrial fibrillation receiving long-term treatment with warfarin or DOACs during peri-procedural management for dental extraction.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2zQZugn

Single Unit 3D Printed Titanium Reconstruction Plate for Maxillary Reconstruction. The Evolution of Surgical Reconstruction for Maxillary Defects. A Case Report and Review of Current Techniques.

Given the complex form and function present in the maxilla and midface, reconstruction of the midface can be particularly challenging. All attempts to reconstruct the midface are best guided by attempting to preserve the functions of the oral cavity, orbit and sinus cavities which abut in the maxilla. While maxillary defects can be treated with a number of approaches, advances in virtual surgical planning and 3-D printing technology have made autologous reconstruction more functional and predictable.1,2,3 With the advent of computer-assisted 3D modeling, surgical planning took a giant leap forward allowing for the first time for surgeons to work with an exact replica of the surgical site.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PvAy3a

The Use Of Vascularized Myo-Osseous Fibula Free Flap To Reconstruct A Hemimandibular Defect With A Concomitant Skull Defect Arising From Stock Condylar Prosthesis Displacement Into The Middle Cranial Fossa

Functional reconstruction of the temporomandibular joint (TMJ) is a controversial topic among oral and maxillofacial surgeons; this controversy gets complicated further when you dive into the dilemma of the ideal reconstructive modality. TMJ defects might result from various etiologies like blunt or penetrating traumatic injuries, advanced degenerative joint disease, various pathological conditions, including benign and malignant conditions, that might arise from the TMJ or adjacent tissues. The reconstruction of the TMJ is vital due to its essential function in mastication, articulation, speech, facial esthetic and symmetry.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PAlt0t

Trans-oral marsupialisation of a large dermoid cyst

True dermoid cysts are rare congenital entities having predilection for periorbital, floor of mouth and submental areas in the head and neck region. They are usually asymptomatic unless they significantly enlarge causing pain, difficulty in swallowing, breathing, speech or vision, depending upon their location. Conventionally, complete excision is treatment of choice.The authors demonstrate a trans-oral approach to marsupialise a large dermoid cyst with a successful outcome and minimal complications.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2zPPqo0

Septic arthritis of the temporomandibular joint in a 10 year old: a case report and literature review.

Septic arthritis of the temporomandibular joint (TMJ) is extremely rare in the paediatric population, with only 9 cases reported in English literature. We report a case of septic TMJ in a 10-year-old female and review the literature for diagnostic criteria and management strategies.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2zVZI60

Single Unit 3D Printed Titanium Reconstruction Plate for Maxillary Reconstruction. The Evolution of Surgical Reconstruction for Maxillary Defects. A Case Report and Review of Current Techniques.

Given the complex form and function present in the maxilla and midface, reconstruction of the midface can be particularly challenging. All attempts to reconstruct the midface are best guided by attempting to preserve the functions of the oral cavity, orbit and sinus cavities which abut in the maxilla. While maxillary defects can be treated with a number of approaches, advances in virtual surgical planning and 3-D printing technology have made autologous reconstruction more functional and predictable.1,2,3 With the advent of computer-assisted 3D modeling, surgical planning took a giant leap forward allowing for the first time for surgeons to work with an exact replica of the surgical site.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PvAy3a

The Use Of Vascularized Myo-Osseous Fibula Free Flap To Reconstruct A Hemimandibular Defect With A Concomitant Skull Defect Arising From Stock Condylar Prosthesis Displacement Into The Middle Cranial Fossa

Functional reconstruction of the temporomandibular joint (TMJ) is a controversial topic among oral and maxillofacial surgeons; this controversy gets complicated further when you dive into the dilemma of the ideal reconstructive modality. TMJ defects might result from various etiologies like blunt or penetrating traumatic injuries, advanced degenerative joint disease, various pathological conditions, including benign and malignant conditions, that might arise from the TMJ or adjacent tissues. The reconstruction of the TMJ is vital due to its essential function in mastication, articulation, speech, facial esthetic and symmetry.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PAlt0t

The NIH Says It Will Spend Up to $20 Million to Find Alternatives to Human Fetal Tissue

The National Institutes of Health (NIH) announced Monday that it will soon embark on a major research effort to find scientific alternatives to human fetal tissue, a switch that may affect research ranging from basic science to drug trials. Human fetal tissue is commonly used by scientists to mimic human biology in order to understand normal development, study the effects of disease or test drugs. Its use in research is legal but fiercely opposed by some pro-life activists, given that it is procured after elective abortions. Over the next two years, the NIH will supply up to $20 million for research that seeks to "develop and/or further refine human tissue models that closely mimic and can be used to faithfully model human embryonic development or other aspects of human biology, for ...

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2L9H1Ac

Incorporating Oral and Maxillofacial Surgeons on Facial Allotransplantation Teams

Facial allotransplantation was introduced over a decade ago in France as an innovative means to restore appearance and function in patients with severe facial disfigurement resulting from high-energy avulsive incidents. Safety and feasibility were shown in several centers worldwide, and ethical and psychological barriers have been overcome. Facial transplantation evolved to include the entire face, both jaws and tongue as reported by Dorafshar et al (1). A standardized treatment algorithm based on classification of injury was developed due to wide variability across institutions performing transplantation (2).

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PAlaCR

The effect of one-suture and suture-less techniques on post-operative healing following third molar surgery.

Wound closure technique for lower third molar surgery (LTMS) is an operative factor that influences wound healing and early post-operative complications. This study investigates two closure techniques; partial closure using one suture and the suture-less technique, after using a modified buccal envelope flap for LTMS.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PxijKT

APE1/Ref-1 could serve as a potential serological biomarker for the diagnosis and prognosis of oral squamous cell carcinoma

Apurinic/apyrimidinic endonuclease 1/redox factor-1 (APE1/Ref-1) is a multifunctional protein that shows elevated expression in many cancers including oral squamous cell carcinoma (OSCC), but the serum APE1/REF-1 level remains unknown in OSCC patients. The purpose of this study was to estimate serum APE/Ref-1 levels in OSCC subjects and to measure its association with the diagnosis, clinicopathological features and prognosis of OSCC.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2A3APpl

A rare complication following anesthesia: arytenoid dislocation during orthognathic surgery

Arytenoid dislocation is one of the rare complications following tracheal intubation, and there are no published studies that report arytenoid dislocation during orthognathic surgery. The frequency of this phenomenon and the results of therapy are evaluated in this study.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PAlly1

Single Unit 3D Printed Titanium Reconstruction Plate for Maxillary Reconstruction. The Evolution of Surgical Reconstruction for Maxillary Defects. A Case Report and Review of Current Techniques.

Given the complex form and function present in the maxilla and midface, reconstruction of the midface can be particularly challenging. All attempts to reconstruct the midface are best guided by attempting to preserve the functions of the oral cavity, orbit and sinus cavities which abut in the maxilla. While maxillary defects can be treated with a number of approaches, advances in virtual surgical planning and 3-D printing technology have made autologous reconstruction more functional and predictable.1,2,3 With the advent of computer-assisted 3D modeling, surgical planning took a giant leap forward allowing for the first time for surgeons to work with an exact replica of the surgical site.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PvAy3a

Effects of Direct Oral Anticoagulants on Quality of Life during Peri-procedural Management for Dental Extractions

Direct oral anticoagulants (DOACs) have many advantages over warfarin regarding the peri-procedural management for dental extractions. They avoid the need to assess and possibly adjust warfarin therapy to achieve an appropriate hemostatic status before and after extraction. This study aimed to evaluate the real-life data regarding quality of life (QoL) and burden for patients with atrial fibrillation receiving long-term treatment with warfarin or DOACs during peri-procedural management for dental extraction.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2zQZugn

The effect of one-suture and suture-less techniques on post-operative healing following third molar surgery.

Wound closure technique for lower third molar surgery (LTMS) is an operative factor that influences wound healing and early post-operative complications. This study investigates two closure techniques; partial closure using one suture and the suture-less technique, after using a modified buccal envelope flap for LTMS.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PxijKT

Septic arthritis of the temporomandibular joint in a 10 year old: a case report and literature review.

Septic arthritis of the temporomandibular joint (TMJ) is extremely rare in the paediatric population, with only 9 cases reported in English literature. We report a case of septic TMJ in a 10-year-old female and review the literature for diagnostic criteria and management strategies.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2zVZI60

The Use Of Vascularized Myo-Osseous Fibula Free Flap To Reconstruct A Hemimandibular Defect With A Concomitant Skull Defect Arising From Stock Condylar Prosthesis Displacement Into The Middle Cranial Fossa

Functional reconstruction of the temporomandibular joint (TMJ) is a controversial topic among oral and maxillofacial surgeons; this controversy gets complicated further when you dive into the dilemma of the ideal reconstructive modality. TMJ defects might result from various etiologies like blunt or penetrating traumatic injuries, advanced degenerative joint disease, various pathological conditions, including benign and malignant conditions, that might arise from the TMJ or adjacent tissues. The reconstruction of the TMJ is vital due to its essential function in mastication, articulation, speech, facial esthetic and symmetry.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PAlt0t

A rare complication following anesthesia: arytenoid dislocation during orthognathic surgery

Arytenoid dislocation is one of the rare complications following tracheal intubation, and there are no published studies that report arytenoid dislocation during orthognathic surgery. The frequency of this phenomenon and the results of therapy are evaluated in this study.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PAlly1

APE1/Ref-1 could serve as a potential serological biomarker for the diagnosis and prognosis of oral squamous cell carcinoma

Apurinic/apyrimidinic endonuclease 1/redox factor-1 (APE1/Ref-1) is a multifunctional protein that shows elevated expression in many cancers including oral squamous cell carcinoma (OSCC), but the serum APE1/REF-1 level remains unknown in OSCC patients. The purpose of this study was to estimate serum APE/Ref-1 levels in OSCC subjects and to measure its association with the diagnosis, clinicopathological features and prognosis of OSCC.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2A3APpl

Incorporating Oral and Maxillofacial Surgeons on Facial Allotransplantation Teams

Facial allotransplantation was introduced over a decade ago in France as an innovative means to restore appearance and function in patients with severe facial disfigurement resulting from high-energy avulsive incidents. Safety and feasibility were shown in several centers worldwide, and ethical and psychological barriers have been overcome. Facial transplantation evolved to include the entire face, both jaws and tongue as reported by Dorafshar et al (1). A standardized treatment algorithm based on classification of injury was developed due to wide variability across institutions performing transplantation (2).

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PAlaCR

Trans-oral marsupialisation of a large dermoid cyst

True dermoid cysts are rare congenital entities having predilection for periorbital, floor of mouth and submental areas in the head and neck region. They are usually asymptomatic unless they significantly enlarge causing pain, difficulty in swallowing, breathing, speech or vision, depending upon their location. Conventionally, complete excision is treatment of choice.The authors demonstrate a trans-oral approach to marsupialise a large dermoid cyst with a successful outcome and minimal complications.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2zPPqo0

APE1/Ref-1 could serve as a potential serological biomarker for the diagnosis and prognosis of oral squamous cell carcinoma

Apurinic/apyrimidinic endonuclease 1/redox factor-1 (APE1/Ref-1) is a multifunctional protein that shows elevated expression in many cancers including oral squamous cell carcinoma (OSCC), but the serum APE1/REF-1 level remains unknown in OSCC patients. The purpose of this study was to estimate serum APE/Ref-1 levels in OSCC subjects and to measure its association with the diagnosis, clinicopathological features and prognosis of OSCC.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2A3APpl

Septic arthritis of the temporomandibular joint in a 10 year old: a case report and literature review.

Septic arthritis of the temporomandibular joint (TMJ) is extremely rare in the paediatric population, with only 9 cases reported in English literature. We report a case of septic TMJ in a 10-year-old female and review the literature for diagnostic criteria and management strategies.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2zVZI60

Incorporating Oral and Maxillofacial Surgeons on Facial Allotransplantation Teams

Facial allotransplantation was introduced over a decade ago in France as an innovative means to restore appearance and function in patients with severe facial disfigurement resulting from high-energy avulsive incidents. Safety and feasibility were shown in several centers worldwide, and ethical and psychological barriers have been overcome. Facial transplantation evolved to include the entire face, both jaws and tongue as reported by Dorafshar et al (1). A standardized treatment algorithm based on classification of injury was developed due to wide variability across institutions performing transplantation (2).

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Single Unit 3D Printed Titanium Reconstruction Plate for Maxillary Reconstruction. The Evolution of Surgical Reconstruction for Maxillary Defects. A Case Report and Review of Current Techniques.

Given the complex form and function present in the maxilla and midface, reconstruction of the midface can be particularly challenging. All attempts to reconstruct the midface are best guided by attempting to preserve the functions of the oral cavity, orbit and sinus cavities which abut in the maxilla. While maxillary defects can be treated with a number of approaches, advances in virtual surgical planning and 3-D printing technology have made autologous reconstruction more functional and predictable.1,2,3 With the advent of computer-assisted 3D modeling, surgical planning took a giant leap forward allowing for the first time for surgeons to work with an exact replica of the surgical site.

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A rare complication following anesthesia: arytenoid dislocation during orthognathic surgery

Arytenoid dislocation is one of the rare complications following tracheal intubation, and there are no published studies that report arytenoid dislocation during orthognathic surgery. The frequency of this phenomenon and the results of therapy are evaluated in this study.

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Trans-oral marsupialisation of a large dermoid cyst

True dermoid cysts are rare congenital entities having predilection for periorbital, floor of mouth and submental areas in the head and neck region. They are usually asymptomatic unless they significantly enlarge causing pain, difficulty in swallowing, breathing, speech or vision, depending upon their location. Conventionally, complete excision is treatment of choice.The authors demonstrate a trans-oral approach to marsupialise a large dermoid cyst with a successful outcome and minimal complications.

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The effect of one-suture and suture-less techniques on post-operative healing following third molar surgery.

Wound closure technique for lower third molar surgery (LTMS) is an operative factor that influences wound healing and early post-operative complications. This study investigates two closure techniques; partial closure using one suture and the suture-less technique, after using a modified buccal envelope flap for LTMS.

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Effects of Direct Oral Anticoagulants on Quality of Life during Peri-procedural Management for Dental Extractions

Direct oral anticoagulants (DOACs) have many advantages over warfarin regarding the peri-procedural management for dental extractions. They avoid the need to assess and possibly adjust warfarin therapy to achieve an appropriate hemostatic status before and after extraction. This study aimed to evaluate the real-life data regarding quality of life (QoL) and burden for patients with atrial fibrillation receiving long-term treatment with warfarin or DOACs during peri-procedural management for dental extraction.

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Financial Analysis: IDEXX Laboratories (IDXX) & Response Genetics (RGDXQ) - Baseball Daily News

Financial Analysis: IDEXX Laboratories (IDXX) & Response Genetics (RGDXQ)  Baseball Daily News

Response Genetics (OTCMKTS:RGDXQ) and IDEXX Laboratories (NASDAQ:IDXX) are both medical companies, but which is the superior business? We will ...

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Billi Mucklow in terrifying cancer scare as she has secret surgery to remove tumour from her neck - The Sun

Billi Mucklow in terrifying cancer scare as she has secret surgery to remove tumour from her neck  The Sun

The former Towie star has since been giving the all clear after suffering five weeks of hell.

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Mizzou is marshaling its forces against cancer - News - Columbia Daily Tribune

Mizzou is marshaling its forces against cancer - News  Columbia Daily Tribune

The University of Missouri is well known for its role in educating the state's workforce and its connections to businesses and communities across Missouri, but ...

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