Precise tracking of vaccine-responding T cell clones reveals convergent and personalized response in identical twins [Immunology and Inflammation]

T cell receptor (TCR) repertoire data contain information about infections that could be used in disease diagnostics and vaccine development, but extracting that information remains a major challenge. Here we developed a statistical framework to detect TCR clone proliferation and contraction from longitudinal repertoire data. We applied this framework to... (Source: Proceedings of the National Academy of Sciences)

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