Conclusion.The SQ HDM SLIT-tablet is a cost-effective treatment option for people with HDM AA in three different health care settings in Eastern Europe. PMID: 30417636 [PubMed - as supplied by publisher] (Source: European Annals of Allergy and Clinical Immunology)
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Authors: Carli G, Farsi A, Chiarini F, Lippolis D, Cortellini G Abstract Summary: Non-vitamin K antagonist oral anticoagulants (NOACs) are increasingly being used in hospital and outpatient settings as safe alternatives to warfarin. Hypersensitivity reactions have been described for NOACs and can be classified according to Gell and Coombs. We reviewed case reports of possible drug hypersensitivity reactions, noticing a predominance of delayed reactions (both mild and severe) and the absence of cross-reactions to warfarin and low molecu-lar weight heparins. International experience on diagnostic tests is lacking. The vast majority of authors refer to probability scores and rely on biopsy to classify vasculitis and rule out differential diagnoses. We propose to adapt available tests ...
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Conclusion. The current study suggests considering both usual and unusual pathogens in laboratory investigation and in the empiric treatment of chronic diarrhea. Opportunistic pathogens should be taken into account when no other pathogen is identified, especially in patients on long-term treatment or prophylaxis with antifungals/antibiotics and in those from geographical locations that favor pathogenicity of these organisms. PMID: 30417635 [PubMed - as supplied by publisher] (Source: European Annals of Allergy and Clinical Immunology)
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Authors: Carli G, Farsi A, Chiarini F, Lippolis D, Cortellini G Abstract Summary: Non-vitamin K antagonist oral anticoagulants (NOACs) are increasingly being used in hospital and outpatient settings as safe alternatives to warfarin. Hypersensitivity reactions have been described for NOACs and can be classified according to Gell and Coombs. We reviewed case reports of possible drug hypersensitivity reactions, noticing a predominance of delayed reactions (both mild and severe) and the absence of cross-reactions to warfarin and low molecu-lar weight heparins. International experience on diagnostic tests is lacking. The vast majority of authors refer to probability scores and rely on biopsy to classify vasculitis and rule out differential diagnoses. We propose to adapt available tests ...
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Conclusion. The current study suggests considering both usual and unusual pathogens in laboratory investigation and in the empiric treatment of chronic diarrhea. Opportunistic pathogens should be taken into account when no other pathogen is identified, especially in patients on long-term treatment or prophylaxis with antifungals/antibiotics and in those from geographical locations that favor pathogenicity of these organisms. PMID: 30417635 [PubMed - as supplied by publisher] (Source: European Annals of Allergy and Clinical Immunology)
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This study was performed to investigate sinus floor augmentation with two different particle sizes of demineralized bovine bone mineral (DBBM) by means of histological and immunohistochemical (IHC) analysis. A randomized clinical trial was conducted involving 10 individuals requiring two-stage bilateral maxillary sinus augmentation for implant installation. The patients were randomly divided into two groups following a split-mouth design: the maxillary sinus on one side was filled with small-sized particles (0.25 –1mm) and on the contralateral side with large-sized particles (1–2mm). (Source: International Journal of Oral and Maxillofacial Surgery)
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ConclusionsHealth services utilization and direct costs of asthma were highly related to disease severity. Nationwide health policies aimed at the effective control of asthma are necessary and would play an important role in reducing the associated economic impact. (Source: World Allergy Organization Journal)
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This study was performed to investigate sinus floor augmentation with two different particle sizes of demineralized bovine bone mineral (DBBM) by means of histological and immunohistochemical (IHC) analysis. A randomized clinical trial was conducted involving 10 individuals requiring two-stage bilateral maxillary sinus augmentation for implant installation. The patients were randomly divided into two groups following a split-mouth design: the maxillary sinus on one side was filled with small-sized particles (0.25 –1mm) and on the contralateral side with large-sized particles (1–2mm). (Source: International Journal of Oral and Maxillofacial Surgery)
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AIT performed with HDM extracts inducing IgG antibodies only to Der p 1 and 2 was beneficial for patients sensitized exclusively to these allergens but not for patients with sensitization to other HDM allergens. (Source: Journal of Allergy and Clinical Immunology)
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Mild forms of vibratory angioedema/pruritus are more common than expected. As the ADGRE2-mutation causing familiar vibratory angioedema was not seen in the population investigated, at least two subtypes must exist. (Source: Journal of Allergy and Clinical Immunology)
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Incorporating component-resolved allergen diagnosis and peanut conjunctival allergen provocation test in the diagnostic algorithm appears to improve health-related quality of life at an acceptable increase in costs, representing the optimal cost-effective diagnostic strategy. (Source: Journal of Allergy and Clinical Immunology)
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(Source: Journal of Allergy and Clinical Immunology)
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Targeting CRF2 and (or) downstream pathways has potential as a new therapeutic approach to limit excessive MC activation and intestinal permeability which initiate and perpetuate highly prevalent and burdensome diseases including allergy, anaphylaxis and functional bowel disorders. (Source: Journal of Allergy and Clinical Immunology)
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Increased mucosal double-negative (DN) CD3+CD4-CD8- T cells were found for the first time in CRS and were much more abundant in uncontrolled CRSwNP than in well-controlled CRSwNP. (Source: Journal of Allergy and Clinical Immunology)
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Using a novel assay for ANA+ plasma cells, we show the presence of a strong tolerance checkpoint. Loss of tolerance in lupus results from expansion of IgG+ plasma cells rather than aberrant antigen-specific selection. (Source: Journal of Allergy and Clinical Immunology)
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AIT performed with HDM extracts inducing IgG antibodies only to Der p 1 and 2 was beneficial for patients sensitized exclusively to these allergens but not for patients with sensitization to other HDM allergens. (Source: Journal of Allergy and Clinical Immunology)
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Ectopic olfactory receptors, such as OR10G7, are differentially expressed in AD vs normal skin. Their functional role likely involves the transduction of skin-induced chemosensory responses to odorant stimulation, which may modulate differential nociceptive responses in AD skin. (Source: Journal of Allergy and Clinical Immunology)
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Mild forms of vibratory angioedema/pruritus are more common than expected. As the ADGRE2-mutation causing familiar vibratory angioedema was not seen in the population investigated, at least two subtypes must exist. (Source: Journal of Allergy and Clinical Immunology)
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Incorporating component-resolved allergen diagnosis and peanut conjunctival allergen provocation test in the diagnostic algorithm appears to improve health-related quality of life at an acceptable increase in costs, representing the optimal cost-effective diagnostic strategy. (Source: Journal of Allergy and Clinical Immunology)
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(Source: Journal of Allergy and Clinical Immunology)
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Targeting CRF2 and (or) downstream pathways has potential as a new therapeutic approach to limit excessive MC activation and intestinal permeability which initiate and perpetuate highly prevalent and burdensome diseases including allergy, anaphylaxis and functional bowel disorders. (Source: Journal of Allergy and Clinical Immunology)
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Increased mucosal double-negative (DN) CD3+CD4-CD8- T cells were found for the first time in CRS and were much more abundant in uncontrolled CRSwNP than in well-controlled CRSwNP. (Source: Journal of Allergy and Clinical Immunology)
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Using a novel assay for ANA+ plasma cells, we show the presence of a strong tolerance checkpoint. Loss of tolerance in lupus results from expansion of IgG+ plasma cells rather than aberrant antigen-specific selection. (Source: Journal of Allergy and Clinical Immunology)
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The purpose of our study was to determine the main anatomical features of the calcarine sulcus using a 3-T MRI.
Fifty human brains have been explored using an MRI 3-T in Doctors Center in Beirut (Lebanon).
The calcarine sulcus was identified in 100% of cases. In most cases, it had a continuous aspect with several peaks. In all our specimens, the calcarine sulcus crosses the parieto-occipital fissure. The majority of their collateral branches and their connections with other sulci were located at the level of the calcarine sulcus properly. In the majority of specimens, the deepest part of the anterior calcarine sulcus forms a protrusion in the occipital horn of the lateral ventricle called calcar avis.
Our study emphasizes the fact that the course patterns of the calcarine sulcus are highly variable. The description of the main anatomical features of the calcarine sulcus obtained from our study can be used as a reference for fMRI exploration and is useful for brain surgery.
The purpose of our study was to determine the main anatomical features of the calcarine sulcus using a 3-T MRI.
Fifty human brains have been explored using an MRI 3-T in Doctors Center in Beirut (Lebanon).
The calcarine sulcus was identified in 100% of cases. In most cases, it had a continuous aspect with several peaks. In all our specimens, the calcarine sulcus crosses the parieto-occipital fissure. The majority of their collateral branches and their connections with other sulci were located at the level of the calcarine sulcus properly. In the majority of specimens, the deepest part of the anterior calcarine sulcus forms a protrusion in the occipital horn of the lateral ventricle called calcar avis.
Our study emphasizes the fact that the course patterns of the calcarine sulcus are highly variable. The description of the main anatomical features of the calcarine sulcus obtained from our study can be used as a reference for fMRI exploration and is useful for brain surgery.
Alexia Dumas, Dan Corral, Andr é Colom, Florence Levillain, Antonio Peixoto, Denis Hudrisier, Yannick Poquet, Olivier Neyrolles (Source: Frontiers in Immunology)
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Meriem Attaf, Amna Malik, Mai C. Severinsen, Julia Roider, Paul Ogongo, S øren Buus, Thumbi Ndung'u, Alasdair Leslie, Henrik N. Kløverpris, Philippa C. Matthews, Andrew K. Sewell, Philip Goulder (Source: Frontiers in Immunology)
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Claudia J. de Dood, Pytsje T. Hoekstra, Julius Mngara, Samuel E. Kalluvya, Govert J. van Dam, Jennifer A. Downs, Paul L. A. M. Corstjens (Source: Frontiers in Immunology)
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Yuhai Chen, Jing Ouyang, Ruoxiang Yan, Mohamed Hassan Maarouf, Xuefei Wang, Biao Chen, Shasha Liu, Jiayue Hu, Guijie Guo, Jing Zhang, Sheng-Ming Dai, Huji Xu, Ji-Long Chen (Source: Frontiers in Immunology)
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Odelia Mouhadeb, Shani Ben Shlomo, Keren Cohen, Inbal Farkash, Shlomo Gruber, Nitsan Maharshak, Zamir Halpern, Ezra Burstein, Nathan Gluck, Chen Varol (Source: Frontiers in Immunology)
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Guan Yang, John P. Driver, Luc Van Kaer (Source: Frontiers in Immunology)
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Yi-Ling Su, Bing Wang, Meng-Die Hu, Zheng-Wei Cui, Jian Wan, Hao Bai, Qian Yang, Yan-Fang Cui, Cui-Hong Wan, Li Xiong, Yong-An Zhang, Hui Geng (Source: Frontiers in Immunology)
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Elouise E. Kroon, Anna K. Coussens, Craig Kinnear, Marianna Orlova, Marlo M öller, Allison Seeger, Robert J. Wilkinson, Eileen G. Hoal, Erwin Schurr (Source: Frontiers in Immunology)
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AbstractAsthma can often be challenging to diagnose especially when patients present with atypical symptoms. Therefore, it is important to have a broad differential diagnosis for asthma to ensure that other conditions are not missed. Clinicians must maintain a high index of suspicion for asthma mimickers, especially when patients fail to respond to conventional therapy. The purpose of this review is to briefly review some of the more common causes of asthma mimickers that clinicians should consider when the diagnosis of asthma is unclear. (Source: World Allergy Organization Journal)
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The immune system is intricately involved in brain development and physiological neuronal function. The influence of the adaptive immune system on several brain diseases has been described in great detail. In ischemic stroke, numerous studies have particularly demonstrated a key role for T cells during the acute phase after the brain injury. Recently, a critical role for T cells has also become more evident for the chronic phase after stroke in modulating delayed neuronal (dys-) function and recovery. (Source: Journal of Neuroimmunology)
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Adult asthma remission can be predicted using baseline clinical measurements obtained in early childhood. Persistent childhood asthmatics with normal baseline measurements of airway obstruction, airways responsiveness, and serum eosinophil count have greater than 80% probability of remission. (Source: Journal of Allergy and Clinical Immunology)
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In this study, we surveyed the effect of multiple polarizing stimuli on human macrophages in the context of cystic fibrosis and asthma. (Source: Journal of Allergy and Clinical Immunology)
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This case demonstrates successful immune reconstitution following hematopoietic stem cell transplantation in NIK deficiency. (Source: Journal of Allergy and Clinical Immunology)
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Michael P. Jeffrey, Janice L. Strap, Holly Jones Taggart, Julia M. Green-Johnson (Source: Frontiers in Immunology)
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Claudia J. de Dood, Pytsje T. Hoekstra, Julius Mngara, Samuel E. Kalluvya, Govert J. van Dam, Jennifer A. Downs, Paul L. A. M. Corstjens (Source: Frontiers in Immunology)
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Yuhai Chen, Jing Ouyang, Ruoxiang Yan, Mohamed Hassan Maarouf, Xuefei Wang, Biao Chen, Shasha Liu, Jiayue Hu, Guijie Guo, Jing Zhang, Sheng-Ming Dai, Huji Xu, Ji-Long Chen (Source: Frontiers in Immunology)
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Jie Liang, Beate Jahraus, Emre Balta, Jacqueline D. Ziegler, Katrin H übner, Norbert Blank, Beate Niesler, Guido H. Wabnitz, Yvonne Samstag (Source: Frontiers in Immunology)
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Yi-Ling Su, Bing Wang, Meng-Die Hu, Zheng-Wei Cui, Jian Wan, Hao Bai, Qian Yang, Yan-Fang Cui, Cui-Hong Wan, Li Xiong, Yong-An Zhang, Hui Geng (Source: Frontiers in Immunology)
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Elouise E. Kroon, Anna K. Coussens, Craig Kinnear, Marianna Orlova, Marlo M öller, Allison Seeger, Robert J. Wilkinson, Eileen G. Hoal, Erwin Schurr (Source: Frontiers in Immunology)
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AbstractAsthma can often be challenging to diagnose especially when patients present with atypical symptoms. Therefore, it is important to have a broad differential diagnosis for asthma to ensure that other conditions are not missed. Clinicians must maintain a high index of suspicion for asthma mimickers, especially when patients fail to respond to conventional therapy. The purpose of this review is to briefly review some of the more common causes of asthma mimickers that clinicians should consider when the diagnosis of asthma is unclear. (Source: World Allergy Organization Journal)
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Gabriele Schramm, Abdulhadi Suwandi, Alibek Galeev, Samriti Sharma, Janin Braun, Anne-Kathrin Claes, Peter Braubach, Guntram A. Grassl (Source: Frontiers in Immunology)
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The immune system is intricately involved in brain development and physiological neuronal function. The influence of the adaptive immune system on several brain diseases has been described in great detail. In ischemic stroke, numerous studies have particularly demonstrated a key role for T cells during the acute phase after the brain injury. Recently, a critical role for T cells has also become more evident for the chronic phase after stroke in modulating delayed neuronal (dys-) function and recovery. (Source: Journal of Neuroimmunology)
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(Source: Journal of Allergy and Clinical Immunology)
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In this study, we surveyed the effect of multiple polarizing stimuli on human macrophages in the context of cystic fibrosis and asthma. (Source: Journal of Allergy and Clinical Immunology)
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This case demonstrates successful immune reconstitution following hematopoietic stem cell transplantation in NIK deficiency. (Source: Journal of Allergy and Clinical Immunology)
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The EPX histologic scoring system can be used to differentiate children with EoE and PPI-REE relative to GERD, supporting the relationship between these 2 groups and enhancing current diagnostic and treatment approaches. (Source: Journal of Allergy and Clinical Immunology)
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This study shows that local immunereactive and functional/blocking allergen-specific IgG4 antibodies in the nasal fluid are induced following grass pollen SCIT. Moreover, nasal blocking antibodies correlated closely with clinical response to SCIT. (Source: Journal of Allergy and Clinical Immunology)
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Authors: PMID: 30417323 [PubMed - in process] (Source: Clinical and Developmental Immunology)
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This article is protected by copyright. All rights reserved. PMID: 30418664 [PubMed - as supplied by publisher] (Source: Immunology)
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Authors: Altmann DM Abstract There is a growing appreciation of the role in the aetiology of metabolic syndrome that is played by the interplay of diet, microbiota and the interactions of immune cells and adipose cells in visceral adipose tissue. Recent studies have highlighted the programmes, properties and roles of the specialized, resident immune subsets that are abundant in adipose tissue, which may be considered a newly identified lymphoid compartment for immunology research. The findings indicate important roles for resident T effector and regulatory cells, innate lymphoid cells (ILCs), invariant natural killer T (iNKT) cells and macrophages, among others. Immunologists are at the very beginning of trying to narrate a story of complex interactions, with the need to unravel ca...
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Authors: PMID: 30417323 [PubMed - in process] (Source: Clinical and Developmental Immunology)
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This article is protected by copyright. All rights reserved. PMID: 30418664 [PubMed - as supplied by publisher] (Source: Immunology)
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| University of Missouri Research Reactor First US I-131 Supplier in 30 Years Imaging Technology News (press release) (blog)Full coverage |
Cell death and inflammation are intimately linked during Yersinia infection. Pathogenic Yersinia inhibits the MAP kinase TGFβ-activated kinase 1 (TAK1) via the effector YopJ, thereby silencing cytokine expression while activating caspase-8–mediated cell death. Here, using Yersinia pseudotuberculosis in corroboration with costimulation of lipopolysaccharide and (5Z)-7-Oxozeaenol, a small-molecule inhibitor of TAK1,... (Source: Proceedings of the National Academy of Sciences)
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Chimeric antigen receptor (CAR) T cells with a long-lived memory phenotype are correlated with durable, complete remissions in patients with leukemia. However, not all CAR T cell products form robust memory populations, and those that do can induce chronic B cell aplasia in patients. To address these challenges, we previously... (Source: Proceedings of the National Academy of Sciences)
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Immunomodulatory drugs (IMiDs), including thalidomide derivatives such as lenalidomide and pomalidomide, offer therapeutic benefit in several hematopoietic malignancies and autoimmune/inflammatory diseases. However, it is difficult to study the IMiD mechanism of action in murine disease models because murine cereblon (CRBN), the substrate receptor for IMiD action, is resistant to some... (Source: Proceedings of the National Academy of Sciences)
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Natural killer (NK) cells play a critical role in controlling malignancies. Susceptibility or resistance to lung cancer, for example, specifically depends on NK cell function. Nevertheless, intrinsic factors that control NK cell-mediated clearance of lung cancer are unknown. Here we report that NK cells exposed to exogenous major histocompatibility class... (Source: Proceedings of the National Academy of Sciences)
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| University of Missouri Research Reactor First US I-131 Supplier in 30 Years Imaging Technology News (press release) (blog)Full coverage |
Cell death and inflammation are intimately linked during Yersinia infection. Pathogenic Yersinia inhibits the MAP kinase TGFβ-activated kinase 1 (TAK1) via the effector YopJ, thereby silencing cytokine expression while activating caspase-8–mediated cell death. Here, using Yersinia pseudotuberculosis in corroboration with costimulation of lipopolysaccharide and (5Z)-7-Oxozeaenol, a small-molecule inhibitor of TAK1,... (Source: Proceedings of the National Academy of Sciences)
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Chimeric antigen receptor (CAR) T cells with a long-lived memory phenotype are correlated with durable, complete remissions in patients with leukemia. However, not all CAR T cell products form robust memory populations, and those that do can induce chronic B cell aplasia in patients. To address these challenges, we previously... (Source: Proceedings of the National Academy of Sciences)
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Immunomodulatory drugs (IMiDs), including thalidomide derivatives such as lenalidomide and pomalidomide, offer therapeutic benefit in several hematopoietic malignancies and autoimmune/inflammatory diseases. However, it is difficult to study the IMiD mechanism of action in murine disease models because murine cereblon (CRBN), the substrate receptor for IMiD action, is resistant to some... (Source: Proceedings of the National Academy of Sciences)
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Natural killer (NK) cells play a critical role in controlling malignancies. Susceptibility or resistance to lung cancer, for example, specifically depends on NK cell function. Nevertheless, intrinsic factors that control NK cell-mediated clearance of lung cancer are unknown. Here we report that NK cells exposed to exogenous major histocompatibility class... (Source: Proceedings of the National Academy of Sciences)
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Series B financing led by 6 Dimensions Capital, Bessemer Venture Partners, and Pfizer Ventures Financing to enable the advancement of lead program into clinical development and support the progression of additional programs CAMBRIDGE, Mass., Nov. 13,... Biopharmaceuticals, Venture Capital, Personnel Kymera Therapeutics, Pegasus (Source: HSMN NewsFeed)
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Upper airway inflammatory diseases are associated with abnormal expression of nasal epithelial forkhead-box J1 (FOXJ1) which regulates motile cilia formation. We sought to investigate whether aberrant FOXJ1 localizations correlate with the disease severity and the co-existence of allergic rhinitis (AR) or asthma in patients with nasal polyps (NPs).
We elucidated localization patterns of FOXJ1 by performing immunofluorescence assays in nasal specimens and cytospin samples from controls and patients with NPs. We also assayed mRNA expression levels of FOXJ1 by using quantitative real-time polymerase chain reaction. Four localization patterns [normal (N), intermediate (I), mislocalization (M), and absence (A)] were defined. A semi-quantitative scoring system was applied for demonstrating FOXJ1 localization in five areas per paraffin section, with individual sections being scored between 0 and 2.
FOXJ1 localization score was significantly higher in samples from NPs than in controls (P < 0.001). Elevated FOXJ1 localization scores and down-regulation of FOXJ1 mRNA levels were observed in NPs with co-existing AR or asthma (all P < 0.05). Moreover, FOXJ1 localization scores positively correlated with Lund–Mackay score (r = 0.362, P = 0.007). Of primary cytospin samples, the mean percentage of patients with FOXJ1 localization patterns N, I, M and A was 15.0%, 3.3%, 53.3% and 28.3% in NPs, and 82.5%, 5.0%, 5.0% and 7.5% in controls, respectively (P < 0.001).
Aberrant localization of FOXJ1 correlates with the severity and co-existence of AR or asthma in patients with NPs, and might be a novel target for assessment and intervention in NPs.
Series B financing led by 6 Dimensions Capital, Bessemer Venture Partners, and Pfizer Ventures Financing to enable the advancement of lead program into clinical development and support the progression of additional programs CAMBRIDGE, Mass., Nov. 13,... Biopharmaceuticals, Venture Capital, Personnel Kymera Therapeutics, Pegasus (Source: HSMN NewsFeed)
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(NIH/National Institute of Allergy and Infectious Diseases) National Institutes of Health scientists and their collaborators found that hepatitis B virus (HBV)-associated acute liver failure (ALF) -- a rare condition that can turn fatal within days without liver transplantation -- results from an uncommon encounter between a highly mutated HBV variant and an unusual immune response in the patient's liver that is mainly sustained by antibody-producing B cells. (Source: EurekAlert! - Medicine and Health)
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Upper airway inflammatory diseases are associated with abnormal expression of nasal epithelial forkhead-box J1 (FOXJ1) which regulates motile cilia formation. We sought to investigate whether aberrant FOXJ1 localizations correlate with the disease severity and the co-existence of allergic rhinitis (AR) or asthma in patients with nasal polyps (NPs).
We elucidated localization patterns of FOXJ1 by performing immunofluorescence assays in nasal specimens and cytospin samples from controls and patients with NPs. We also assayed mRNA expression levels of FOXJ1 by using quantitative real-time polymerase chain reaction. Four localization patterns [normal (N), intermediate (I), mislocalization (M), and absence (A)] were defined. A semi-quantitative scoring system was applied for demonstrating FOXJ1 localization in five areas per paraffin section, with individual sections being scored between 0 and 2.
FOXJ1 localization score was significantly higher in samples from NPs than in controls (P < 0.001). Elevated FOXJ1 localization scores and down-regulation of FOXJ1 mRNA levels were observed in NPs with co-existing AR or asthma (all P < 0.05). Moreover, FOXJ1 localization scores positively correlated with Lund–Mackay score (r = 0.362, P = 0.007). Of primary cytospin samples, the mean percentage of patients with FOXJ1 localization patterns N, I, M and A was 15.0%, 3.3%, 53.3% and 28.3% in NPs, and 82.5%, 5.0%, 5.0% and 7.5% in controls, respectively (P < 0.001).
Aberrant localization of FOXJ1 correlates with the severity and co-existence of AR or asthma in patients with NPs, and might be a novel target for assessment and intervention in NPs.
Condition: HIV Infections Intervention: Biological: VRC07-523LS Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) Not yet recruiting (Source: ClinicalTrials.gov)
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Conditions: CTLA4 Haplonisufficiency; Chronic Cytopernia Interventions: Drug: Orencia (abatacept); Other: Placebo Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) Recruiting (Source: ClinicalTrials.gov)
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Conditions: Influenza; Influenza-like Illness Interventions: Biological: Egg based influenza vaccines; Biological: Recombinant influenza vaccines; Biological: Cell-culture based influenza vaccines Sponsors: Henry M. Jackson Foundation for the Advancement of Military Medicine; National Institute of Allergy and Infectious Diseases (NIAID); Food and Drug Administration (FDA); Defense Health Agency Immunization Healthcare Branch; Armed Forces Health Surveillance Branch; Naval He alth Research Center; United States Air Force School of Aerospace Medicine; Uniformed Services University of the Health Sciences Not yet recruiting (Source: ClinicalTrials.gov)
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Conditions: Anesthesia; Pediatric Cancer; Pediatric Tumor; Pediatric Hepatoblastoma; Beta-Thalassemia; Hepatic Metastases Intervention: Drug: Sugammadex Sponsor: Federal Research Institute of Pediatric Hematology, Oncology and Immunology Not yet recruiting (Source: ClinicalTrials.gov)
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Condition: Rabies Intervention: Biological: Blood drawn after rabies vaccine booster vaccination Sponsor: Queen Saovabha Memorial Institute Not yet recruiting (Source: ClinicalTrials.gov)
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Conditions: Spatial Hearing Perception in Cochlear Implant Children; Normal Hearing Children Interventions: Other: behavioral exploration of spatial hearing performances; Other: The Speech, Spatial and Qualities of Hearing Scale (SSQ) questionnaire (for cochlear implant children and their parents); Other: The Speech, Spatial and Qualities of Hearing Scale (SSQ) questionnaire (for parents of CI c hildren) Sponsor: Hospices Civils de Lyon Not yet recruiting (Source: ClinicalTrials.gov)
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Condition: HIV Infections Intervention: Biological: VRC07-523LS Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) Not yet recruiting (Source: ClinicalTrials.gov)
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Conditions: Atopic Dermatitis; Eczema Intervention: Behavioral: Patient reminders and accountability questionnaires Sponsors: McMaster University; Hamilton Allergy Recruiting (Source: ClinicalTrials.gov)
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Condition: Hiv Intervention: Other: HIVD+/R+ Sponsors: Johns Hopkins University; National Institute of Allergy and Infectious Diseases (NIAID) Not yet recruiting (Source: ClinicalTrials.gov)
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Conditions: CTLA4 Haplonisufficiency; Chronic Cytopernia Interventions: Drug: Orencia (abatacept); Other: Placebo Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) Recruiting (Source: ClinicalTrials.gov)
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Conditions: Influenza; Influenza-like Illness Interventions: Biological: Egg based influenza vaccines; Biological: Recombinant influenza vaccines; Biological: Cell-culture based influenza vaccines Sponsors: Henry M. Jackson Foundation for the Advancement of Military Medicine; National Institute of Allergy and Infectious Diseases (NIAID); Food and Drug Administration (FDA); Defense Health Agency Immunization Healthcare Branch; Armed Forces Health Surveillance Branch; Naval He alth Research Center; United States Air Force School of Aerospace Medicine; Uniformed Services University of the Health Sciences Not yet recruiting (Source: ClinicalTrials.gov)
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Condition: HIV Intervention: Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) Recruiting (Source: ClinicalTrials.gov)
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Conditions: Lactational Amenorrhea; Body Weight Changes; Bone Loss Intervention: Other: Exercise and dietary Sponsor: North Carolina Agriculture& Technical State University Not yet recruiting (Source: ClinicalTrials.gov)
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Conditions: Systemic Nickel Allergy Syndrome; Quality of Life Intervention: Biological: Nickel oral hyposensitization treatment Sponsor: Catholic University of the Sacred Heart Recruiting (Source: ClinicalTrials.gov)
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Conditions: Anesthesia; Pediatric Cancer; Pediatric Tumor; Pediatric Hepatoblastoma; Beta-Thalassemia; Hepatic Metastases Intervention: Drug: Sugammadex Sponsor: Federal Research Institute of Pediatric Hematology, Oncology and Immunology Not yet recruiting (Source: ClinicalTrials.gov)
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Condition: Rabies Intervention: Biological: Blood drawn after rabies vaccine booster vaccination Sponsor: Queen Saovabha Memorial Institute Not yet recruiting (Source: ClinicalTrials.gov)
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Conditions: Spatial Hearing Perception in Cochlear Implant Children; Normal Hearing Children Interventions: Other: behavioral exploration of spatial hearing performances; Other: The Speech, Spatial and Qualities of Hearing Scale (SSQ) questionnaire (for cochlear implant children and their parents); Other: The Speech, Spatial and Qualities of Hearing Scale (SSQ) questionnaire (for parents of CI c hildren) Sponsor: Hospices Civils de Lyon Not yet recruiting (Source: ClinicalTrials.gov)
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Over the last few decades, advances in our understanding of microbial ecology have allowed us to appreciate the important role of microbial communities in maintaining human health. While much of this research has focused on gut microbes, microbial communities in other body sites and from the environment are increasingly recognized in human disease. Here, we discuss recent advances in our understanding of host–microbiota interactions in the development and manifestation of asthma focusing on three distinct microbial compartments. First, environmental microbes originating from house dust, pets, and farm animals have been linked to asthma pathogenesis, which is often connected to their production of bioactive molecules such as lipopolysaccharide. Second, respiratory microbial communities, including newly appreciated populations of microbes in the lung have been associated with allergic airway inflammation. Current evidence suggests that the presence of particular microbes, especially Streptococcus, Haemophilus, and Morexella species within the airway may shape local immune responses and alter the severity and manifestations of airway inflammation. Third, the gut microbiota has been implicated in both experimental models and clinical studies in predisposing to asthma. There appears to be a "critical window" of colonization that occurs during early infancy in which gut microbial communities shape immune maturation and confer susceptibility to allergic airway inflammation. The mechanisms by which gut microbial communities influence lung immune responses and physiology, the "gut–lung axis," are still being defined but include the altered differentiation of immune cell populations important in asthma and the local production of metabolites that affect distal sites. Together, these findings suggest an intimate association of microbial communities with host immune development and the development of allergic airway inflammation. Improved understanding of these relationships raises the possibility of microbiota-directed therapies to improve or prevent asthma.
Over the last few decades, advances in our understanding of microbial ecology have allowed us to appreciate the important role of microbial communities in maintaining human health. While much of this research has focused on gut microbes, microbial communities in other body sites and from the environment are increasingly recognized in human disease. Here, we discuss recent advances in our understanding of host–microbiota interactions in the development and manifestation of asthma focusing on three distinct microbial compartments. First, environmental microbes originating from house dust, pets, and farm animals have been linked to asthma pathogenesis, which is often connected to their production of bioactive molecules such as lipopolysaccharide. Second, respiratory microbial communities, including newly appreciated populations of microbes in the lung have been associated with allergic airway inflammation. Current evidence suggests that the presence of particular microbes, especially Streptococcus, Haemophilus, and Morexella species within the airway may shape local immune responses and alter the severity and manifestations of airway inflammation. Third, the gut microbiota has been implicated in both experimental models and clinical studies in predisposing to asthma. There appears to be a "critical window" of colonization that occurs during early infancy in which gut microbial communities shape immune maturation and confer susceptibility to allergic airway inflammation. The mechanisms by which gut microbial communities influence lung immune responses and physiology, the "gut–lung axis," are still being defined but include the altered differentiation of immune cell populations important in asthma and the local production of metabolites that affect distal sites. Together, these findings suggest an intimate association of microbial communities with host immune development and the development of allergic airway inflammation. Improved understanding of these relationships raises the possibility of microbiota-directed therapies to improve or prevent asthma.
Over the last few decades, advances in our understanding of microbial ecology have allowed us to appreciate the important role of microbial communities in maintaining human health. While much of this research has focused on gut microbes, microbial communities in other body sites and from the environment are increasingly recognized in human disease. Here, we discuss recent advances in our understanding of host–microbiota interactions in the development and manifestation of asthma focusing on three distinct microbial compartments. First, environmental microbes originating from house dust, pets, and farm animals have been linked to asthma pathogenesis, which is often connected to their production of bioactive molecules such as lipopolysaccharide. Second, respiratory microbial communities, including newly appreciated populations of microbes in the lung have been associated with allergic airway inflammation. Current evidence suggests that the presence of particular microbes, especially Streptococcus, Haemophilus, and Morexella species within the airway may shape local immune responses and alter the severity and manifestations of airway inflammation. Third, the gut microbiota has been implicated in both experimental models and clinical studies in predisposing to asthma. There appears to be a "critical window" of colonization that occurs during early infancy in which gut microbial communities shape immune maturation and confer susceptibility to allergic airway inflammation. The mechanisms by which gut microbial communities influence lung immune responses and physiology, the "gut–lung axis," are still being defined but include the altered differentiation of immune cell populations important in asthma and the local production of metabolites that affect distal sites. Together, these findings suggest an intimate association of microbial communities with host immune development and the development of allergic airway inflammation. Improved understanding of these relationships raises the possibility of microbiota-directed therapies to improve or prevent asthma.
Series B financing led by 6 Dimensions Capital, Bessemer Venture Partners, and Pfizer Ventures Financing to enable the advancement of lead program into clinical development and support the progression of additional programs CAMBRIDGE, Mass., Nov. 13,... Biopharmaceuticals, Venture Capital, Personnel Kymera Therapeutics, Pegasus (Source: HSMN NewsFeed)
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Over the last few decades, advances in our understanding of microbial ecology have allowed us to appreciate the important role of microbial communities in maintaining human health. While much of this research has focused on gut microbes, microbial communities in other body sites and from the environment are increasingly recognized in human disease. Here, we discuss recent advances in our understanding of host–microbiota interactions in the development and manifestation of asthma focusing on three distinct microbial compartments. First, environmental microbes originating from house dust, pets, and farm animals have been linked to asthma pathogenesis, which is often connected to their production of bioactive molecules such as lipopolysaccharide. Second, respiratory microbial communities, including newly appreciated populations of microbes in the lung have been associated with allergic airway inflammation. Current evidence suggests that the presence of particular microbes, especially Streptococcus, Haemophilus, and Morexella species within the airway may shape local immune responses and alter the severity and manifestations of airway inflammation. Third, the gut microbiota has been implicated in both experimental models and clinical studies in predisposing to asthma. There appears to be a "critical window" of colonization that occurs during early infancy in which gut microbial communities shape immune maturation and confer susceptibility to allergic airway inflammation. The mechanisms by which gut microbial communities influence lung immune responses and physiology, the "gut–lung axis," are still being defined but include the altered differentiation of immune cell populations important in asthma and the local production of metabolites that affect distal sites. Together, these findings suggest an intimate association of microbial communities with host immune development and the development of allergic airway inflammation. Improved understanding of these relationships raises the possibility of microbiota-directed therapies to improve or prevent asthma.
Series B financing led by 6 Dimensions Capital, Bessemer Venture Partners, and Pfizer Ventures Financing to enable the advancement of lead program into clinical development and support the progression of additional programs CAMBRIDGE, Mass., Nov. 13,... Biopharmaceuticals, Venture Capital, Personnel Kymera Therapeutics, Pegasus (Source: HSMN NewsFeed)
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(NIH/National Institute of Allergy and Infectious Diseases) National Institutes of Health scientists and their collaborators found that hepatitis B virus (HBV)-associated acute liver failure (ALF) -- a rare condition that can turn fatal within days without liver transplantation -- results from an uncommon encounter between a highly mutated HBV variant and an unusual immune response in the patient's liver that is mainly sustained by antibody-producing B cells. (Source: EurekAlert! - Medicine and Health)
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Authors: Vajaitu C, Draghici CC, Solomon I, Lisievici CV, Popa AV, Lupu M, Caruntu C, Constantin MM, Voiculescu VM Abstract An important function of the immune system is its ability to differentiate between healthy cells in the organism and "foreign" cells, allowing the latest to be attacked and the first ones to be conserved. The most important molecules in this process are considered to be checkpoint inhibitors. This review is focused on the association between cancer and inflammation, underlying the mechanisms of action of monoclonal antibodies that are targeting checkpoint inhibitors: ipilimumab against cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and pembrolizumab and nivolumab against programmed cell death protein 1 (PD-1), their indications for treatment, and side ef...
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In this study, we isolated specific anti-ICOSL new antigen receptor domains from a synthetic phage display library and demonstrated their ability to block the ICOS/ICOSL interaction and inhibit T cell proliferation. Anti-mouse ICOSL domains, considered here as surrogates for the use of anti-human ICOSL domains in patient therapy, were tested for efficacy in a collagen-induced mouse model of rheumatoid arthritis where they significantly decreased the inflammation of joints and delayed and reduced overall disease progression and severity. PMID: 30417018 [PubMed - in process] (Source: Journal of Immunology Research)
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Authors: Sapkota M, Knoell DL Abstract Zinc is an essential micronutrient known to play a vital role in host defense against pathogens. Diets that are deficient in zinc lead to impaired immunity and delayed recovery from and worse outcomes following infection. Sustained insufficient zinc intake leads to dysregulation of the innate immune response and increases susceptibility to infection whereas zinc supplementation in at-risk populations has been shown to restore host defense and reduce pathogen-related morbidity and mortality. Upon infection, zinc deficiency leads to increased pathology due to imbalance in key signaling networks that result in excessive inflammation and collateral tissue damage. In particular, zinc impacts macrophage function, a critical front-line cell in host d...
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Authors: Dobre M, Milanesi E, Mănuc TE, Arsene DE, Ţieranu CG, Maj C, Becheanu G, Mănuc M Abstract Genetic research has shaped the inflammatory bowel disease (IBD) landscape identifying nearly two hundred risk loci. Nonetheless, the identified variants rendered only a partial success in providing criteria for the differential diagnosis between ulcerative colitis (UC) and Crohn's disease (CD). Transcript levels from affected intestinal mucosa may serve as tentative biomarkers for improving classification and diagnosis of IBD. The aim of our study was to identify gene expression profiles specific for UC and CD, in endoscopically affected and normal intestinal colonic mucosa from IBD patients. We evaluated a panel of 84 genes related to the IBD-inflammatory pathway on 21 UC and 22 ...
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ConclusionsInteractions between pairs of sIgE components are associated with increased risk of asthma and may provide the basis for designing diagnostic tools for asthma. (Source: PLoS Medicine)
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| Thyroid Cancer Drugs Market Entry Strategies, Countermeasures of Economic Impact and Marketing Channels to 2026 Coherent Wire (press release) (blog)Thyroid Cancer Drugs Market Analysis, Guidelines Overview and Upcoming Trends Forecast till 2026 Coherent News (press release) (blog)Thyroid Cancer Drugs Market Growth, Demand, And Value Is Increasing In The Upcoming Years Morgan Newspaper USA (press release) (blog)Full coverage |
| Head and Neck Cancer Survivors Have Increased Suicide Risk Oncology Nurse AdvisorFull coverage |
| Head and Neck Cancer Market Changing the Outlook for Many Terminal Cancer Patients Coherent Wire (press release) (blog)Head and Neck Cancer Therapeutics Market | Global Industry Analysis, Segments, Top Key Players, Drivers and ... News by Sharp Reports (press release) (blog)Global Head and Neck Cancer Market Types, Application, Trends, Status and Analysis Research Report 2018-2025 Honest FactsFull coverage |
Authors: Vajaitu C, Draghici CC, Solomon I, Lisievici CV, Popa AV, Lupu M, Caruntu C, Constantin MM, Voiculescu VM Abstract An important function of the immune system is its ability to differentiate between healthy cells in the organism and "foreign" cells, allowing the latest to be attacked and the first ones to be conserved. The most important molecules in this process are considered to be checkpoint inhibitors. This review is focused on the association between cancer and inflammation, underlying the mechanisms of action of monoclonal antibodies that are targeting checkpoint inhibitors: ipilimumab against cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and pembrolizumab and nivolumab against programmed cell death protein 1 (PD-1), their indications for treatment, and side ef...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2qLhy72
In this study, we isolated specific anti-ICOSL new antigen receptor domains from a synthetic phage display library and demonstrated their ability to block the ICOS/ICOSL interaction and inhibit T cell proliferation. Anti-mouse ICOSL domains, considered here as surrogates for the use of anti-human ICOSL domains in patient therapy, were tested for efficacy in a collagen-induced mouse model of rheumatoid arthritis where they significantly decreased the inflammation of joints and delayed and reduced overall disease progression and severity. PMID: 30417018 [PubMed - in process] (Source: Journal of Immunology Research)
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Authors: Sapkota M, Knoell DL Abstract Zinc is an essential micronutrient known to play a vital role in host defense against pathogens. Diets that are deficient in zinc lead to impaired immunity and delayed recovery from and worse outcomes following infection. Sustained insufficient zinc intake leads to dysregulation of the innate immune response and increases susceptibility to infection whereas zinc supplementation in at-risk populations has been shown to restore host defense and reduce pathogen-related morbidity and mortality. Upon infection, zinc deficiency leads to increased pathology due to imbalance in key signaling networks that result in excessive inflammation and collateral tissue damage. In particular, zinc impacts macrophage function, a critical front-line cell in host d...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2qMy5rc
ConclusionsInteractions between pairs of sIgE components are associated with increased risk of asthma and may provide the basis for designing diagnostic tools for asthma. (Source: PLoS Medicine)
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
| Thyroid Cancer Drugs Market Entry Strategies, Countermeasures of Economic Impact and Marketing Channels to 2026 Coherent Wire (press release) (blog)Thyroid Cancer Drugs Market Analysis, Guidelines Overview and Upcoming Trends Forecast till 2026 Coherent News (press release) (blog)Thyroid Cancer Drugs Market Growth, Demand, And Value Is Increasing In The Upcoming Years Morgan Newspaper USA (press release) (blog)Full coverage |
| Head and Neck Cancer Survivors Have Increased Suicide Risk Oncology Nurse AdvisorFull coverage |
| Head and Neck Cancer Market Changing the Outlook for Many Terminal Cancer Patients Coherent Wire (press release) (blog)Head and Neck Cancer Therapeutics Market | Global Industry Analysis, Segments, Top Key Players, Drivers and ... News by Sharp Reports (press release) (blog)Global Head and Neck Cancer Market Types, Application, Trends, Status and Analysis Research Report 2018-2025 Honest FactsFull coverage |
The foundation, started by the Pittsburgh Penguins owner and legendary player, has already given $25 million to UPMC for other efforts. (Source: bizjournals.com Health Care:Physician Practices headlines)
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In conclusion, therefore, standard bedside airway examination tests for difficult airways in patients with no apparent airway abnormalities do not appear to be good screening tests, and we urge great caution in their use and interpretation. "Read the Cochrane ReviewVisit theCochrane Anaesthesia, Critical and Emergency Care websiteListen to more Cochrane PodcastsGet Cochrane Podcasts on iTunesTuesday, November 13, 2018 (Source: Cochrane News and Events)
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In this study, for all-comers, that was an abysmal 6%. This is an important number because it tells us that overall, successful resuscitation from cardiac arrest is rare and that a number of our efforts may have some statistically significant differences but the absolute effect on the gold standard outcome is rather small. But that's a story for another time. The focus here is on airway management in cardiac arrest, and the suggestion that the "verdict is out" on whether or not paramedics should be using an endotracheal tube or a supraglottic device. (Source: JEMS Patient Care)
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The foundation, started by the Pittsburgh Penguins owner and legendary player, has already given $25 million to UPMC for other efforts. (Source: bizjournals.com Health Care:Physician Practices headlines)
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
In conclusion, therefore, standard bedside airway examination tests for difficult airways in patients with no apparent airway abnormalities do not appear to be good screening tests, and we urge great caution in their use and interpretation. "Read the Cochrane ReviewVisit theCochrane Anaesthesia, Critical and Emergency Care websiteListen to more Cochrane PodcastsGet Cochrane Podcasts on iTunesTuesday, November 13, 2018 (Source: Cochrane News and Events)
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
In this study, for all-comers, that was an abysmal 6%. This is an important number because it tells us that overall, successful resuscitation from cardiac arrest is rare and that a number of our efforts may have some statistically significant differences but the absolute effect on the gold standard outcome is rather small. But that's a story for another time. The focus here is on airway management in cardiac arrest, and the suggestion that the "verdict is out" on whether or not paramedics should be using an endotracheal tube or a supraglottic device. (Source: JEMS Patient Care)
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Asthma can often be challenging to diagnose especially when patients present with atypical symptoms. Therefore, it is important to have a broad differential diagnosis for asthma to ensure that other conditions are not missed. Clinicians must maintain a high index of suspicion for asthma mimickers, especially when patients fail to respond to conventional therapy. The purpose of this review is to briefly review some of the more common causes of asthma mimickers that clinicians should consider when the diagnosis of asthma is unclear.
FREE ACCESS through November 27, 2018.
Latest Impact Factor: 7.557
The Official Journal of: American Thyroid Association®
Read now:
Immune-Related Thyroiditis with Immune Checkpoint Inhibitors
Priyanka C. Iyer, Maria E. Cabanillas, Steven G. Waguespack, Mimi I. Hu, Sonali Thosani, Victor R. Lavis, Naifa L. Busaidy, Sumit K. Subudhi, Adi Diab, and Ramona Dadu
Patients with Benign Thyroid Diseases Experience an Impaired Sex Life
Nadia Sawicka-Gutaj, Marek Ruchala, Ulla Feldt-Rasmussen, Åse Krogh Rasmussen, Laszlo Hegedüs, Steen Joop Bonnema, Mogens Groenvold, Jakob Bue Bjorner, and Torquil Watt
Thyroid Cancer Treatment Choice: A Pilot Study of a Tool to Facilitate Conversations with Patients with Papillary Microcarcinomas Considering Treatment Options
Juan P. Brito, Jae Hoon Moon, Rebecca Zeuren, Sung Hye Kong, Yeo Goon Kim, Nicole M. Iñiguez-Ariza, June Young Choi, Kyu Eun Lee, Ji-hoon Kim, Ian Hargraves, Victor Bernet, Victor M. Montori, Young Joo Park, and R. Michael Tuttle
Association of Thyroid Function and Autoimmunity with Ovarian Reserve in Women Seeking Infertility Care
Tim I.M. Korevaar, Lidia Mínguez-Alarcón, Carmen Messerlian, Ralph A. de Poortere, Paige L. Williams, Maarten A. Broeren, Russ Hauser, and Irene C. Souter
Hyperthyroidism and Papillary Thyroid Carcinoma in Thyrotropin Receptor D633H Mutant Mice
Holger Jaeschke, Henriette Undeutsch, Konrad Patyra, Christoffer Löf, Markus Eszlinger, Moosa Khalil, Meeri Jännäri, Kristiina Makkonen, Jorma Toppari, Fu-Ping Zhang, Matti Poutanen, Ralf Paschke, and Jukka Kero
The post <i>Thyroid<sup>®</sup></i> High-Impact Articles appeared first on American Thyroid Association.
Asthma can often be challenging to diagnose especially when patients present with atypical symptoms. Therefore, it is important to have a broad differential diagnosis for asthma to ensure that other conditions are not missed. Clinicians must maintain a high index of suspicion for asthma mimickers, especially when patients fail to respond to conventional therapy. The purpose of this review is to briefly review some of the more common causes of asthma mimickers that clinicians should consider when the diagnosis of asthma is unclear.
FREE ACCESS through November 27, 2018.
Latest Impact Factor: 7.557
The Official Journal of: American Thyroid Association®
Read now:
Immune-Related Thyroiditis with Immune Checkpoint Inhibitors
Priyanka C. Iyer, Maria E. Cabanillas, Steven G. Waguespack, Mimi I. Hu, Sonali Thosani, Victor R. Lavis, Naifa L. Busaidy, Sumit K. Subudhi, Adi Diab, and Ramona Dadu
Patients with Benign Thyroid Diseases Experience an Impaired Sex Life
Nadia Sawicka-Gutaj, Marek Ruchala, Ulla Feldt-Rasmussen, Åse Krogh Rasmussen, Laszlo Hegedüs, Steen Joop Bonnema, Mogens Groenvold, Jakob Bue Bjorner, and Torquil Watt
Thyroid Cancer Treatment Choice: A Pilot Study of a Tool to Facilitate Conversations with Patients with Papillary Microcarcinomas Considering Treatment Options
Juan P. Brito, Jae Hoon Moon, Rebecca Zeuren, Sung Hye Kong, Yeo Goon Kim, Nicole M. Iñiguez-Ariza, June Young Choi, Kyu Eun Lee, Ji-hoon Kim, Ian Hargraves, Victor Bernet, Victor M. Montori, Young Joo Park, and R. Michael Tuttle
Association of Thyroid Function and Autoimmunity with Ovarian Reserve in Women Seeking Infertility Care
Tim I.M. Korevaar, Lidia Mínguez-Alarcón, Carmen Messerlian, Ralph A. de Poortere, Paige L. Williams, Maarten A. Broeren, Russ Hauser, and Irene C. Souter
Hyperthyroidism and Papillary Thyroid Carcinoma in Thyrotropin Receptor D633H Mutant Mice
Holger Jaeschke, Henriette Undeutsch, Konrad Patyra, Christoffer Löf, Markus Eszlinger, Moosa Khalil, Meeri Jännäri, Kristiina Makkonen, Jorma Toppari, Fu-Ping Zhang, Matti Poutanen, Ralf Paschke, and Jukka Kero
The post <i>Thyroid<sup>®</sup></i> High-Impact Articles appeared first on American Thyroid Association.
This article is protected by copyright. All rights reserved. PMID: 30417986 [PubMed - as supplied by publisher] (Source: Anatomical Record)
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This article is protected by copyright. All rights reserved. PMID: 30417986 [PubMed - as supplied by publisher] (Source: Anatomical Record)
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Fluid overloading is detrimental to organ function and results in a poor prognosis. It is necessary to evaluate fluid responsiveness before fluid loading. We performed a systematic meta-analysis to evaluate the diagnostic value of the respiratory variation in peripheral arterial blood flow peak velocity (△Vpeak PA) in predicting fluid responsiveness in mechanically ventilated patients.
PubMed, Embase and The Cochrane Library databases were searched for studies that used △Vpeak PA to predict fluid responsiveness in mechanically ventilated patients. We calculated the pooled values of sensitivity, specificity and the area of the summary receiver operating characteristic curve by Meta-Disc 14.0 software.
Nine studies with a total of 402 patients were included. Two low quality studies were deleted in further analysis. Moreover, because of different locations of peripheral artery, the rest included studies were divided into brachial site group and carotid site group for meta-analysis individually. The pooled sensitivity, specificity and area under curve were 0.85 (95% confidence interval (CI) 0.77–0.92), 0.86 (95% CI 0.77–0.92) and 0.9268 in carotid site group. The pooled sensitivity, specificity and area under curve were 0.72 (95% CI 0.60–0.81), 0.85 (95% CI 0.74–0.93) and 0.8587 in brachial site group.
△Vpeak of carotid and brachial artery had a diagnostic value in predicting fluid responsiveness respectively. Moreover, △Vpeak of carotid artery had more value than brachial artery in predicting fluid responsiveness. However, there was some clinical heterogeneity; therefore, further studies are needed to confirm diagnostic accuracy.
Fluid overloading is detrimental to organ function and results in a poor prognosis. It is necessary to evaluate fluid responsiveness before fluid loading. We performed a systematic meta-analysis to evaluate the diagnostic value of the respiratory variation in peripheral arterial blood flow peak velocity (△Vpeak PA) in predicting fluid responsiveness in mechanically ventilated patients.
PubMed, Embase and The Cochrane Library databases were searched for studies that used △Vpeak PA to predict fluid responsiveness in mechanically ventilated patients. We calculated the pooled values of sensitivity, specificity and the area of the summary receiver operating characteristic curve by Meta-Disc 14.0 software.
Nine studies with a total of 402 patients were included. Two low quality studies were deleted in further analysis. Moreover, because of different locations of peripheral artery, the rest included studies were divided into brachial site group and carotid site group for meta-analysis individually. The pooled sensitivity, specificity and area under curve were 0.85 (95% confidence interval (CI) 0.77–0.92), 0.86 (95% CI 0.77–0.92) and 0.9268 in carotid site group. The pooled sensitivity, specificity and area under curve were 0.72 (95% CI 0.60–0.81), 0.85 (95% CI 0.74–0.93) and 0.8587 in brachial site group.
△Vpeak of carotid and brachial artery had a diagnostic value in predicting fluid responsiveness respectively. Moreover, △Vpeak of carotid artery had more value than brachial artery in predicting fluid responsiveness. However, there was some clinical heterogeneity; therefore, further studies are needed to confirm diagnostic accuracy.
The foundation, started by the Pittsburgh Penguins owner and legendary player, has already given $25 million to UPMC for other efforts. (Source: bizjournals.com Health Care:Physician Practices headlines)
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The Official Journal of: American Thyroid Association®
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The post <i>Thyroid<sup>®</sup></i> High-Impact Articles appeared first on American Thyroid Association.
The foundation, started by the Pittsburgh Penguins owner and legendary player, has already given $25 million to UPMC for other efforts. (Source: bizjournals.com Health Care:Physician Practices headlines)
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
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The Official Journal of: American Thyroid Association®
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Priyanka C. Iyer, Maria E. Cabanillas, Steven G. Waguespack, Mimi I. Hu, Sonali Thosani, Victor R. Lavis, Naifa L. Busaidy, Sumit K. Subudhi, Adi Diab, and Ramona Dadu
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We describe a new modification of thromboaspiration to facilitate recanalization, referred to as the "back and forth" manual aspiration technique.
In this technique, the aspiration catheter (SOFIA Plus catheter, MicroVentionInc, Tustin, CA, USA) is positioned adjacent to the occluded segment and then advanced over the thrombus during manual aspiration with a 50-cc syringe.
We evaluated this technique in 15 patients who presented to our institution with acute ischemic stroke (AIS). Final mTICI 2b/3 was achieved in 86.6% of the patients with the sole use of this new aspiration technique. No dissection, rupture, or downstream emboli were associated with the procedure. The mean time from puncture to revascularization was 35 min.
This modified technique with back and forth movements of the SOFIA Plus catheter over the thrombus during aspiration may facilitate thrombectomy in AIS. However, further studies in larger groups are necessary to elucidate its efficacy and to compare with current techniques.
We describe a new modification of thromboaspiration to facilitate recanalization, referred to as the "back and forth" manual aspiration technique.
In this technique, the aspiration catheter (SOFIA Plus catheter, MicroVentionInc, Tustin, CA, USA) is positioned adjacent to the occluded segment and then advanced over the thrombus during manual aspiration with a 50-cc syringe.
We evaluated this technique in 15 patients who presented to our institution with acute ischemic stroke (AIS). Final mTICI 2b/3 was achieved in 86.6% of the patients with the sole use of this new aspiration technique. No dissection, rupture, or downstream emboli were associated with the procedure. The mean time from puncture to revascularization was 35 min.
This modified technique with back and forth movements of the SOFIA Plus catheter over the thrombus during aspiration may facilitate thrombectomy in AIS. However, further studies in larger groups are necessary to elucidate its efficacy and to compare with current techniques.
This study was performed to investigate sinus floor augmentation with two different particle sizes of demineralized bovine bone mineral (DBBM) by means of histological and immunohistochemical (IHC) analysis. A randomized clinical trial was conducted involving 10 individuals requiring two-stage bilateral maxillary sinus augmentation for implant installation. The patients were randomly divided into two groups following a split-mouth design: the maxillary sinus on one side was filled with small-sized particles (0.25–1mm) and on the contralateral side with large-sized particles (1–2mm).
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Authors: Bayón J, Santás-Álvarez M, Ocaranza-Sánchez R, González-Juanatey C PMID: 30418158 [PubMed - as supplied by publisher] (Source: EuroIntervention)
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Anne Wilson, He Fu, Mariano Schiffrin, Carine Winkler, Meriem Koufany, Jean-Yves Jouzeau, Nicolas Bonnet, Federica Gilardi, Fran çois Renevey, Sanjiv A. Luther, David Moulin, Béatrice Desvergne (Source: Frontiers in Immunology)
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Carlos G. P. Voogdt, Mark E. Merchant, Jaap A. Wagenaar, Jos P. M. van Putten (Source: Frontiers in Immunology)
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Fang Zhou, Guang-Xian Zhang, Abdolmohamad Rostami (Source: Frontiers in Immunology)
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Discussion: These data further expand the model of how estrogens and other steroid hormones interact with the inflammatory pathways following injury and may prove beneficial when developing therapies for treatment of TBI.Neuroimmunomodulation (Source: Neuroimmunomodulation)
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This study was performed to investigate sinus floor augmentation with two different particle sizes of demineralized bovine bone mineral (DBBM) by means of histological and immunohistochemical (IHC) analysis. A randomized clinical trial was conducted involving 10 individuals requiring two-stage bilateral maxillary sinus augmentation for implant installation. The patients were randomly divided into two groups following a split-mouth design: the maxillary sinus on one side was filled with small-sized particles (0.25–1mm) and on the contralateral side with large-sized particles (1–2mm).
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Anne Wilson, He Fu, Mariano Schiffrin, Carine Winkler, Meriem Koufany, Jean-Yves Jouzeau, Nicolas Bonnet, Federica Gilardi, Fran çois Renevey, Sanjiv A. Luther, David Moulin, Béatrice Desvergne (Source: Frontiers in Immunology)
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