Several evidences emphasize B-cell pathogenic roles in multiple sclerosis (MS).We performed transcriptome analyses on peripheral B cells from therapy-free patients and age/sex-matched controls. Down-regulation of two transcripts (interferon response factor 1 –IRF1, and C-X-C motif chemokine 10–CXCL10), belonging to the same pathway, was validated by RT-PCR in 26 patients and 21 controls. IRF1 and CXCL10 transcripts share potential seeding sequences for hsa-miR-424, that resulted up-regulated in MS patients. (Source: Journal of Neuroimmunology)
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Σάββατο 15 Σεπτεμβρίου 2018
Analysis of coding and non-coding transcriptome of peripheral B cells reveals an altered interferon response factor (IRF)-1 pathway in multiple sclerosis patients
Long-term persistence of anti-rods and rings antibodies in patients with chronic hepatitis C after antiviral treatment
AbstractAnti-rods and rings (anti-RR) antibodies are related to hepatitis C virus (HCV) in patients treated with pegylated interferon (PEG-IFN) and ribavirin (RBV). Only RBV induces rods/rings structures in vitro; but in vivo, the antibody appearance is related to the combination of these drugs, because data about patients using just one of these drugs alone is missing. Some studies suggest disappearance of these antibodies over time. The aim of this study was to describe the occurrence of anti-RR in patients with chronic hepatitis C treatment-na ïve or previously PEG-IFN/RBV-experienced, evaluating the persistence of anti-RR antibodies long after PEG-IFN/RBV treatment. From 2016 to 2017, 70 HCV-infected patients were screened for anti-RR using indirect immunofluorescence. Demographic and...
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Bcl2L12 plays a critical role in the development of airway allergy via inducing aberrant T helper-2 polarization
Bcl2L12 plays an important role in the pathogenesis of allergic asthma by promoting the differentiation of Th2 cells, which may be a novel therapeutic target in the treatment of allergic asthma (Source: Journal of Allergy and Clinical Immunology)
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β-eudesmol inhibits thymic stromal lymphopoietin through blockade of caspase-1/NF-κB signal cascade in allergic rhinitis murine model.
Authors: Moon PD, Han NR, Lee JS, Kim HY, Hong S, Kim HJ, Yoo MS, Kim HM, Jeong HJ Abstract Allergic rhinitis (AR) is a global health problem because of its steadily increasing incidence and prevalence that currently affects about 30% of people worldwide. β-eudesmol has various beneficial effects, including anti-cancer and anti-allergic activities. However, the effects of β-eudesmol on AR have not yet been clarified; thus, we investigated the effects of β-eudesmol in an ovalbumin-induced AR animal model using enzyme-linked immunosorbent assay, histamine assay, Western blotting, and hematoxylin and eosin staining methods. β-eudesmol reduced the nasal rubs score and levels of histamine and immunoglobulin E in serum of AR mouse. In addition, the levels of thymic stromal lymphopoie...
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Analysis of coding and non-coding transcriptome of peripheral B cells reveals an altered interferon response factor (IRF)-1 pathway in multiple sclerosis patients
Several evidences emphasize B-cell pathogenic roles in multiple sclerosis (MS).We performed transcriptome analyses on peripheral B cells from therapy-free patients and age/sex-matched controls. Down-regulation of two transcripts (interferon response factor 1 –IRF1, and C-X-C motif chemokine 10–CXCL10), belonging to the same pathway, was validated by RT-PCR in 26 patients and 21 controls. IRF1 and CXCL10 transcripts share potential seeding sequences for hsa-miR-424, that resulted up-regulated in MS patients. (Source: Journal of Neuroimmunology)
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Long-term persistence of anti-rods and rings antibodies in patients with chronic hepatitis C after antiviral treatment
AbstractAnti-rods and rings (anti-RR) antibodies are related to hepatitis C virus (HCV) in patients treated with pegylated interferon (PEG-IFN) and ribavirin (RBV). Only RBV induces rods/rings structures in vitro; but in vivo, the antibody appearance is related to the combination of these drugs, because data about patients using just one of these drugs alone is missing. Some studies suggest disappearance of these antibodies over time. The aim of this study was to describe the occurrence of anti-RR in patients with chronic hepatitis C treatment-na ïve or previously PEG-IFN/RBV-experienced, evaluating the persistence of anti-RR antibodies long after PEG-IFN/RBV treatment. From 2016 to 2017, 70 HCV-infected patients were screened for anti-RR using indirect immunofluorescence. Demographic and...
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Bcl2L12 plays a critical role in the development of airway allergy via inducing aberrant T helper-2 polarization
Bcl2L12 plays an important role in the pathogenesis of allergic asthma by promoting the differentiation of Th2 cells, which may be a novel therapeutic target in the treatment of allergic asthma (Source: Journal of Allergy and Clinical Immunology)
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We need taxation as one of the strategies to tackle alcohol abuse, gov't has to take action on this serious problem
| We need taxation as one of the strategies to tackle alcohol abuse, gov't has to take action on this serious problem Stabroek NewsFull coverage |
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We need taxation as one of the strategies to tackle alcohol abuse, gov't has to take action on this serious problem
| We need taxation as one of the strategies to tackle alcohol abuse, gov't has to take action on this serious problem Stabroek NewsFull coverage |
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Comparing Allergist And Cardiologist Considerations For The Optimal Management Of Thienopyridines Hypersensitivity.
Authors: Calogiuri G, Parlangeli C, Mirizzi AM, Macchia L, Foti C, Savage MP Abstract The thienopyridine family includes ticlopidine, clopidogrel and prasugrel which are antiplatelet drugs largely used, mainly associated to aspirin, for treatment of acute coronary syndromes and after percutaneous coronary interventions, to avoid thrombosis. In some patients, thienpyridines may cause hypersensitivity reactions which jeopardize the optimal therapeutic and preventive approach to vascular diseases. The management of thienopyridine hypersensitivity is best done as an interdisciplinary collaboration between the allergist and cardiologist. For the cardiologist, the important issues are the necessity of continuing therapy, the desired duration of therapy based on the clinical indication of...
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Comparing Allergist And Cardiologist Considerations For The Optimal Management Of Thienopyridines Hypersensitivity.
Authors: Calogiuri G, Parlangeli C, Mirizzi AM, Macchia L, Foti C, Savage MP Abstract The thienopyridine family includes ticlopidine, clopidogrel and prasugrel which are antiplatelet drugs largely used, mainly associated to aspirin, for treatment of acute coronary syndromes and after percutaneous coronary interventions, to avoid thrombosis. In some patients, thienpyridines may cause hypersensitivity reactions which jeopardize the optimal therapeutic and preventive approach to vascular diseases. The management of thienopyridine hypersensitivity is best done as an interdisciplinary collaboration between the allergist and cardiologist. For the cardiologist, the important issues are the necessity of continuing therapy, the desired duration of therapy based on the clinical indication of...
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FIERCE for a cure: Natick boot camp raises money for cancer research
| FIERCE for a cure: Natick boot camp raises money for cancer research Milford Daily NewsFull coverage |
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FIERCE for a cure: Natick boot camp raises money for cancer research
| FIERCE for a cure: Natick boot camp raises money for cancer research Milford Daily NewsFull coverage |
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Impact of reduced exposure to calcineurin inhibitors on the development of de novo DSA: a cohort of non-immunized first kidney graft recipients between 2007 and 2014
In low-immunological risk kidney transplant recipients (KTRs), reduced exposure to calcineurin inhibitor (CNI) appears particularly attractive for avoiding adverse events, but may increase the risk of developi... (Source: BMC Nephrology)
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PCAF fine-tunes hepatic metabolic syndrome, inflammatory disease, and cancer.
Authors: Wang T, Yao W, Shao Y, Zheng R, Huang F Abstract The P300/CBP-associating factor (PCAF), a histone acetyltransferase, is involved in metabolic and pathogenic diseases, particularly of the liver. The effects of PCAF on fine-tuning liver diseases are extremely complex and vary according to different pathological conditions. This enzyme has dichotomous functions, depending on differently modified sites, which regulate the activities of various enzymes, metabolic functions, and gene expression. Here, we summarize the most recent findings on the functions and targets of PCAF in various metabolic and immunological processes in the liver and review these new discoveries and models of PCAF biology in three areas: hepatic metabolic syndrome, inflammatory disease, and cancer. Finall...
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Impact of reduced exposure to calcineurin inhibitors on the development of de novo DSA: a cohort of non-immunized first kidney graft recipients between 2007 and 2014
In low-immunological risk kidney transplant recipients (KTRs), reduced exposure to calcineurin inhibitor (CNI) appears particularly attractive for avoiding adverse events, but may increase the risk of developi... (Source: BMC Nephrology)
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PCAF fine-tunes hepatic metabolic syndrome, inflammatory disease, and cancer.
Authors: Wang T, Yao W, Shao Y, Zheng R, Huang F Abstract The P300/CBP-associating factor (PCAF), a histone acetyltransferase, is involved in metabolic and pathogenic diseases, particularly of the liver. The effects of PCAF on fine-tuning liver diseases are extremely complex and vary according to different pathological conditions. This enzyme has dichotomous functions, depending on differently modified sites, which regulate the activities of various enzymes, metabolic functions, and gene expression. Here, we summarize the most recent findings on the functions and targets of PCAF in various metabolic and immunological processes in the liver and review these new discoveries and models of PCAF biology in three areas: hepatic metabolic syndrome, inflammatory disease, and cancer. Finall...
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Multimorbidity and health-related quality of life in Koreans aged 50 or older using KNHANES 2013–2014
Multimorbidity negatively affects health outcomes and impairs health-related quality of life (HRQoL). We assessed the prevalence of multimorbidity in Koreans aged 50 and older, taking into consideration their ...
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Multimorbidity and health-related quality of life in Koreans aged 50 or older using KNHANES 2013–2014
Multimorbidity negatively affects health outcomes and impairs health-related quality of life (HRQoL). We assessed the prevalence of multimorbidity in Koreans aged 50 and older, taking into consideration their ...
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Head and Neck Cancer Treatment Market Report Introduction:
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Transient Cancer Cell Population Successfully Captured in New Study
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Head and Neck Cancer Treatment Market Report Introduction:
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Transient Cancer Cell Population Successfully Captured in New Study
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Head And Neck Cancer Treatment Market Analysis, Overview, Growth, Share, Demand and Forecast Research Report ...
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Head And Neck Cancer Treatment Market Analysis, Overview, Growth, Share, Demand and Forecast Research Report ...
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Head and Neck Cancer Treatment Market Report Introduction:
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Optim Partners with 21st Century Oncology as the Preferred Vendor for Head and Neck Cancer Endoscopy
| Optim Partners with 21st Century Oncology as the Preferred Vendor for Head and Neck Cancer Endoscopy PR Newswire (press release)Full coverage |
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Head and Neck Cancer Treatment Market Report Introduction:
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Optim Partners with 21st Century Oncology as the Preferred Vendor for Head and Neck Cancer Endoscopy
| Optim Partners with 21st Century Oncology as the Preferred Vendor for Head and Neck Cancer Endoscopy PR Newswire (press release)Full coverage |
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A comparison of CD105 and CD31 expression in tumor vessels of hepatocellular carcinoma by tissue microarray and flow cytometry.
In this study, we investigated the endothelial markers CD105 and CD31 in the tumor vessels from 90 patients with hepatocellular carcinoma (HCC) by tissue microarray, in addition to their expression in TECs isolated from fresh tissues resected from 11 patients with HCC by flow cytometry and confocal microscopy. The results revealed that among 90 cases of TMA, all tumor vessels were CD31 positive whereas 39 cases (43.3%) had little or no CD105 expression in tumors and their vessels but not peritumoral tissue spots, and that among these 39, 29 cases (74.4%) were poor-differentiated HCC. These findings were further verified by flow cytometry and confocal analysis of TECs isolated from HCC. Overall, the results suggested that CD105 may not be expressed in TECs derived from poor-differentiated H...
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A comparison of CD105 and CD31 expression in tumor vessels of hepatocellular carcinoma by tissue microarray and flow cytometry.
In this study, we investigated the endothelial markers CD105 and CD31 in the tumor vessels from 90 patients with hepatocellular carcinoma (HCC) by tissue microarray, in addition to their expression in TECs isolated from fresh tissues resected from 11 patients with HCC by flow cytometry and confocal microscopy. The results revealed that among 90 cases of TMA, all tumor vessels were CD31 positive whereas 39 cases (43.3%) had little or no CD105 expression in tumors and their vessels but not peritumoral tissue spots, and that among these 39, 29 cases (74.4%) were poor-differentiated HCC. These findings were further verified by flow cytometry and confocal analysis of TECs isolated from HCC. Overall, the results suggested that CD105 may not be expressed in TECs derived from poor-differentiated H...
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Gummiinhaltsstoffe
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Ein Schritt zur besseren Verfügbarkeit
Die Verfügbarkeit von Testallergenen zur Abklärung von Allergien, die gegen seltene Allergieauslöser gerichtet sind, ist von öffentlichem Interesse. In den letzten Jahren haben Zulassungsinhaber aber viele Zulassungen von Testallergenen für seltene Allergieauslöser zurückgegeben — Ursache: der geringe wirtschaftlich Nutzen. Dem will das Paul-Ehrlich-Institut nun entgegenwirken und reduziert die Gebühren für Amtshandlungen im Zusammenhang mit diesen Arzneimitteln.
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HAE-Prophylaxe mit Plasma-Kallikrein-Inhibitor
Das hereditäre Angioödem kann potenziell lebensbedrohlich sein, was eine Therapie umso notwendiger macht. Ein Plasma-Kallikrein-Inhibitor soll nun Abhilfe schaffen und die Attacken unterbinden.
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Duftstoffe als Allergene
Zusammenfassung
Kontaktallergien durch Duftstoffe sind häufig. Zählt man die Reaktionshäufigkeiten der Indikatoren einer Duftstoffallergie zusammen (Duftstoffmix [DM] I + II, Perubalsam und Terpentinöl), dann erreichen sie im Klinikkollektiv (IVDK-Daten 2016) 17 %, und liegen damit sogar vor der Nickelallergie (etwa 16 %). Bei den „+"-positiven Reaktionen auf den DM I reagieren > 50 % nicht auf eine der Komponenten. Derartige Reaktionen sollten zurückhaltend als allergisch interpretiert werden. Es sei denn, weitere Daten (z. B. positive Anamnese, Gebrauchstest) stützen eine solche Interpretation.
DM-I-Positive reagieren häufig auf Eichenmoos (27,2 %) und Isoeugenol (18,2 %). Es folgen Hydroxycitronellal (10,9 %), Cinnamal (10,6 %), Cinnamyl alcohol (8,4 %), Eugenol (7,3 %), Geraniol (5,5 %) und Amyl Cinnamal (1,5 %). Die Sensibilisierungshäufigkeiten (SH) der einzelnen Duftstoffe sind abhängig von der allergenen Potenz (erfasst durch den lokalen Lymphknotentest; englisch „local lymph node assay", LLNA) und der Nutzungshäufigkeit (Maß der Exposition). Die Relation zwischen SH und Exposition wird mit dem SEQ („sensitization exposure"-Quotient) beschrieben. Der SEQ ist ein Maß für das Sensibilisierungsrisiko. In der Regel korreliert dies einerseits mit der SH, andererseits mit der allergenen Potenz („hazard"/Gefahr). Abweichungen von dieser Regel zeigen ein neu erkanntes Problem an: a) Methyl 2-octynoat spielte in der SH-Statistik keine Rolle, lag aber mit seinem SEQ (= Risiko) nach Baum- und Eichenmoos an dritter Stelle, b) Hydroxyisohexyl 3-cyclohexene carboxaldehyde (Lyral®) hatte trotz schwacher Potenz ein relativ hohes Risiko. Die Determinante des Risikos war in diesem Fall nicht die Potenz (das inhärente „hazard"), sondern zu hohe Einsatzdosen.
Die Allergieüberwachung durch die klinische Epidemiologie sollte in Zukunft verstärkt ergänzt werden durch Daten zur Exposition.
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Adrenalin-Autoinjektor: Lieferengpass voraussichtlich bald beendet
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AeDA erzielt wichtigen Erfolg für Patienten
Im Jahr 2016 kam es zu einem Tiefpunkt in der Versorgung von Patienten mit allergischer Rhinitis in Deutschland: Durch die Entlassung der nasalen Glukokortikoide Beclomethason, Fluticason und Mometason aus der Verschreibungspflicht waren plötzlich fast keine Medikamente für Rhinitispatienten mehr zulasten der gesetzlichen Krankenversicherungen rezeptierbar. Der Ärzteverband Deutscher Allergologen hat sich von Anfang an mit der Problematik auseinandergesetzt — mit Erfolg.
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Placeboeffekt in der Immuntherapie ist abhängig von der Applikation
Wie überall in der Medizin gibt es auch in der Immuntherapie von Allergien Placeboeffekte. Wie stark sie ausfallen, hängt offenbar von der Art der Verabreichung ab.
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Für eine Welt ohne Allergien
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Verlängerung in Hessen erreicht!
Der AeDA hat für die deutschen Allergologen in den letzten Jahren die Aufnahme von Diagnostikallergenen für nasale Provokationstestungen in die Sprechstundenbedarfsverordnungen der meisten KV-Regionen erreicht — vor dem Hintergrund, die wirtschaftlichen Zwänge bei der Erbringung allergologischer Leistungen zu verbessern. In Hessen wurde nun diese Vereinbarung bis zum 30. Juni 2019 verlängert.
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Inhaltsverzeichnis
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Cerdioxid-Nanopartikel induzieren Typ-II-Entzündungsreaktion der Atemwege
Nanopartikel mit seltenen Erden wie Cerdioxid werden industriell genutzt, interagieren allerdings unter anderem aufgrund ihrer hohen Redoxkapazität auch mit lebendem Gewebe. Im Mausmodell wurden jetzt Entzündungsreaktionen der Atemwege nach Cerdioxid-Exposition überprüft.
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Diesmal auf S3-Niveau
Der Vorstand der Deutschen Gesellschaft für Allergologie und klinische Immunologie hat nach intensiven Gesprächen auf dem letzten Treffen in Hannover entschieden, die nächste Leitlinie zur Allergen-spezifischen Immuntherapie als evidenzbasierte Leitlinie auf S3-Niveau bei der Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften anzumelden. Dies ist ein wichtiger Schritt für den zukünftigen Stellenwert dieser Therapieform als einzige krankheitsmodifizierende Behandlungsoption für allergische Patienten.
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Nahrungsmittelprovokationstest verbessert die Lebensqualität
Nahrungsmittelallergien haben in den letzten Jahren stark zugenommen. Betroffene Kinder und deren Eltern werden durch eine permanent notwendige Wachsamkeit und die Angst vor anaphylaktischen Reaktionen oft sehr belastet. Eine orale Nahrungsmittelprovokation schafft Klarheit und verbessert dadurch die Lebensqualität.
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Alles nur eine Frage der Einbildung?
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Ein Schritt zur besseren Verfügbarkeit
Die Verfügbarkeit von Testallergenen zur Abklärung von Allergien, die gegen seltene Allergieauslöser gerichtet sind, ist von öffentlichem Interesse. In den letzten Jahren haben Zulassungsinhaber aber viele Zulassungen von Testallergenen für seltene Allergieauslöser zurückgegeben — Ursache: der geringe wirtschaftlich Nutzen. Dem will das Paul-Ehrlich-Institut nun entgegenwirken und reduziert die Gebühren für Amtshandlungen im Zusammenhang mit diesen Arzneimitteln.
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AIT bei Erdnussallergie: per os oder sublingual?
Zur Behandlung von Erdnussallergien sind sowohl orale als auch sublinguale Immuntherapien Erfolg versprechend. Eine Bestandsaufnahme.
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HAE-Prophylaxe mit Plasma-Kallikrein-Inhibitor
Das hereditäre Angioödem kann potenziell lebensbedrohlich sein, was eine Therapie umso notwendiger macht. Ein Plasma-Kallikrein-Inhibitor soll nun Abhilfe schaffen und die Attacken unterbinden.
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Comparison of sublingual immunotherapy and oral immunotherapy in peanut allergy
Abstract
The prevalence of food allergy has been increasing over the past few decades at an alarming rate with peanut allergy affecting about 2 % of children. Both oral immunotherapy (OIT) and sublingual immunotherapy (SLIT) have shown promise as a treatment option for peanut allergy. Immunotherapy induces desensitization and reduces the risk of reaction during accidental ingestion and may also enable those who are successfully desensitized to include the food allergen in their diet. OIT has been very well studied and has been found to be more efficacious than SLIT with an acceptable safety profile. However, SLIT is associated with fewer side effects. Studies indicate that a combination of SLIT and OIT may together induce a significant increase in challenge thresholds with fewer adverse events. More head-to-head clinical trials that directly compare OIT and SLIT as well as SLIT and OIT combination studies are warranted.
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Duftstoffe als Allergene
Zusammenfassung
Kontaktallergien durch Duftstoffe sind häufig. Zählt man die Reaktionshäufigkeiten der Indikatoren einer Duftstoffallergie zusammen (Duftstoffmix [DM] I + II, Perubalsam und Terpentinöl), dann erreichen sie im Klinikkollektiv (IVDK-Daten 2016) 17 %, und liegen damit sogar vor der Nickelallergie (etwa 16 %). Bei den „+"-positiven Reaktionen auf den DM I reagieren > 50 % nicht auf eine der Komponenten. Derartige Reaktionen sollten zurückhaltend als allergisch interpretiert werden. Es sei denn, weitere Daten (z. B. positive Anamnese, Gebrauchstest) stützen eine solche Interpretation.
DM-I-Positive reagieren häufig auf Eichenmoos (27,2 %) und Isoeugenol (18,2 %). Es folgen Hydroxycitronellal (10,9 %), Cinnamal (10,6 %), Cinnamyl alcohol (8,4 %), Eugenol (7,3 %), Geraniol (5,5 %) und Amyl Cinnamal (1,5 %). Die Sensibilisierungshäufigkeiten (SH) der einzelnen Duftstoffe sind abhängig von der allergenen Potenz (erfasst durch den lokalen Lymphknotentest; englisch „local lymph node assay", LLNA) und der Nutzungshäufigkeit (Maß der Exposition). Die Relation zwischen SH und Exposition wird mit dem SEQ („sensitization exposure"-Quotient) beschrieben. Der SEQ ist ein Maß für das Sensibilisierungsrisiko. In der Regel korreliert dies einerseits mit der SH, andererseits mit der allergenen Potenz („hazard"/Gefahr). Abweichungen von dieser Regel zeigen ein neu erkanntes Problem an: a) Methyl 2-octynoat spielte in der SH-Statistik keine Rolle, lag aber mit seinem SEQ (= Risiko) nach Baum- und Eichenmoos an dritter Stelle, b) Hydroxyisohexyl 3-cyclohexene carboxaldehyde (Lyral®) hatte trotz schwacher Potenz ein relativ hohes Risiko. Die Determinante des Risikos war in diesem Fall nicht die Potenz (das inhärente „hazard"), sondern zu hohe Einsatzdosen.
Die Allergieüberwachung durch die klinische Epidemiologie sollte in Zukunft verstärkt ergänzt werden durch Daten zur Exposition.
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Warum scheitern Studien zur Immuntherapie?
Trotz vielversprechender Vorergebnisse bringen Studien zur Hyposensibilisierung in der Phase III zuweilen nicht die erhofften Ergebnisse. In einem Review wurden Gründe für unerwartete Resultate beleuchtet.
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Adrenalin-Autoinjektor: Lieferengpass voraussichtlich bald beendet
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AeDA erzielt wichtigen Erfolg für Patienten
Im Jahr 2016 kam es zu einem Tiefpunkt in der Versorgung von Patienten mit allergischer Rhinitis in Deutschland: Durch die Entlassung der nasalen Glukokortikoide Beclomethason, Fluticason und Mometason aus der Verschreibungspflicht waren plötzlich fast keine Medikamente für Rhinitispatienten mehr zulasten der gesetzlichen Krankenversicherungen rezeptierbar. Der Ärzteverband Deutscher Allergologen hat sich von Anfang an mit der Problematik auseinandergesetzt — mit Erfolg.
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Mehr wissen, Probleme lösen
Acht Jahre ist es her, dass die dritte Auflage des „Weißbuch Allergie in Deutschland" erschienen ist. Derzeit wird das Werk rundum erneuert — mit dem Ziel, die Öffentlichkeit besser über Allergien zu informieren, die aktuellen Probleme in der Allergologie dar- sowie entsprechende Lösungsvorschläge vorzustellen. Voraussichtlich ab November wird die vierte Auflage des Weißbuchs im Springer Medizin Verlag erscheinen.
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Für eine Welt ohne Allergien
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Verlängerung in Hessen erreicht!
Der AeDA hat für die deutschen Allergologen in den letzten Jahren die Aufnahme von Diagnostikallergenen für nasale Provokationstestungen in die Sprechstundenbedarfsverordnungen der meisten KV-Regionen erreicht — vor dem Hintergrund, die wirtschaftlichen Zwänge bei der Erbringung allergologischer Leistungen zu verbessern. In Hessen wurde nun diese Vereinbarung bis zum 30. Juni 2019 verlängert.
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Allergologie — aktuelle Events, Ereignisse und Entscheidungen
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Inhaltsverzeichnis
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Cerdioxid-Nanopartikel induzieren Typ-II-Entzündungsreaktion der Atemwege
Nanopartikel mit seltenen Erden wie Cerdioxid werden industriell genutzt, interagieren allerdings unter anderem aufgrund ihrer hohen Redoxkapazität auch mit lebendem Gewebe. Im Mausmodell wurden jetzt Entzündungsreaktionen der Atemwege nach Cerdioxid-Exposition überprüft.
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Nahrungsmittelprovokationstest verbessert die Lebensqualität
Nahrungsmittelallergien haben in den letzten Jahren stark zugenommen. Betroffene Kinder und deren Eltern werden durch eine permanent notwendige Wachsamkeit und die Angst vor anaphylaktischen Reaktionen oft sehr belastet. Eine orale Nahrungsmittelprovokation schafft Klarheit und verbessert dadurch die Lebensqualität.
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Alles nur eine Frage der Einbildung?
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AIT bei Erdnussallergie: per os oder sublingual?
Zur Behandlung von Erdnussallergien sind sowohl orale als auch sublinguale Immuntherapien Erfolg versprechend. Eine Bestandsaufnahme.
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Comparison of sublingual immunotherapy and oral immunotherapy in peanut allergy
Abstract
The prevalence of food allergy has been increasing over the past few decades at an alarming rate with peanut allergy affecting about 2 % of children. Both oral immunotherapy (OIT) and sublingual immunotherapy (SLIT) have shown promise as a treatment option for peanut allergy. Immunotherapy induces desensitization and reduces the risk of reaction during accidental ingestion and may also enable those who are successfully desensitized to include the food allergen in their diet. OIT has been very well studied and has been found to be more efficacious than SLIT with an acceptable safety profile. However, SLIT is associated with fewer side effects. Studies indicate that a combination of SLIT and OIT may together induce a significant increase in challenge thresholds with fewer adverse events. More head-to-head clinical trials that directly compare OIT and SLIT as well as SLIT and OIT combination studies are warranted.
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Warum scheitern Studien zur Immuntherapie?
Trotz vielversprechender Vorergebnisse bringen Studien zur Hyposensibilisierung in der Phase III zuweilen nicht die erhofften Ergebnisse. In einem Review wurden Gründe für unerwartete Resultate beleuchtet.
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Abstracts, 13. Deutscher Allergiekongress, Dresden, 27.–29. September 2018
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Streamlining grommet pathways for otitis media with effusion and hearing loss in children: our experience.
CONCLUSION: Direct-listing pathways for grommet insertion can reduce waiting times and expedite surgery. Implementation involves a simple alteration of current practice, adhering to National Institute for Health and Care Excellence Clinical Guideline 60. The ultimate decision regarding surgery still rests with ENT specialists. PMID: 30208983 [PubMed - as supplied by publisher] (Source: Journal of Laryngology and Otology)
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Streamlining grommet pathways for otitis media with effusion and hearing loss in children: our experience.
CONCLUSION: Direct-listing pathways for grommet insertion can reduce waiting times and expedite surgery. Implementation involves a simple alteration of current practice, adhering to National Institute for Health and Care Excellence Clinical Guideline 60. The ultimate decision regarding surgery still rests with ENT specialists. PMID: 30208983 [PubMed - as supplied by publisher] (Source: Journal of Laryngology and Otology)
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Woman Battling Cancer to Receive Bone Marrow Transplant from Her 14-Year-Old Daughter
| Woman Battling Cancer to Receive Bone Marrow Transplant from Her 14-Year-Old Daughter FOX40Full coverage |
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Woman Battling Cancer to Receive Bone Marrow Transplant from Her 14-Year-Old Daughter
| Woman Battling Cancer to Receive Bone Marrow Transplant from Her 14-Year-Old Daughter FOX40Full coverage |
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Transient Cancer Cell Population Successfully Captured in New Study
| Transient Cancer Cell Population Successfully Captured in New Study Technology NetworksFull coverage |
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Transient Cancer Cell Population Successfully Captured in New Study
| Transient Cancer Cell Population Successfully Captured in New Study Technology NetworksFull coverage |
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Bcl2L12 plays a critical role in the development of airway allergy via inducing aberrant T helper-2 polarization
Bcl2L12 plays an important role in the pathogenesis of allergic asthma by promoting the differentiation of Th2 cells, which may be a novel therapeutic target in the treatment of allergic asthma
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Bcl2L12 plays a critical role in the development of airway allergy via inducing aberrant T helper-2 polarization
Bcl2L12 plays an important role in the pathogenesis of allergic asthma by promoting the differentiation of Th2 cells, which may be a novel therapeutic target in the treatment of allergic asthma
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From vaccines to global health to vaccines
. (Source: Human Vaccines and Immunotherapeutics)
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The structure of situation models as revealed by anaphor resolution
Publication date: Available online 14 September 2018Source: Language SciencesAuthor(s): Sashank Varma, Amanda JanssenAbstractThis paper investigates the structure of situation models as revealed by the process of anaphor resolution. The situation model for a text combines the meanings of its individual sentences with inferences generated from prior knowledge into an overall understanding of the text. We conceptualize situation models as implemented by collections of traces in episodic long-term memory that are retrieved based on their similarity to cues in working memory. Traces encode both contextual (i.e., spatial and temporal) and semantic information, providing structure to situation models. Four predictions were derived regarding the retrieval of antecedent traces during anaphor resol...
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Is there a pluralia tantum subcategory of nominal gerunds? Developing Gaeta's notion of morphological differentiation
Publication date: Available online 14 September 2018Source: Language SciencesAuthor(s): J. Lachlan MackenzieAbstractInspired by Gaeta's study of morphological distinctiveness as the basis for category formation, this article considers the possibility that by virtue of their invariable suffix -ings English pluralia tantum nominal gerunds (PTNGs) such as surroundings can be regarded as a subcategory of nominal gerunds. It is shown that the set of PTNGs is semantically very disparate with regard to the verb that underwent nominalization in the course of their formation. Differences are observed in a very large corpus with regard to the quantifiers and other items that co-occur with PTNGs, namely quantifiers regularly associated with plural count (e.g. many) or with mass nouns (e.g. much), but...
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Green biosynthesis of silver nanoparticles produced from marine Streptomyces sp. Al-Dhabi-89 and their potential applications against wound infection and drug resistant clinical pathogens
In conclusion, the silver nanoparticles produced from marine Streptomyces sp. Al-Dhabi-89 exhibited potential activity against both standard and clinical drug resistant microbial pathogens.Graphical Abstract (Source: Journal of Photochemistry and Photobiology B: Biology)
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Social and configural effects on the cognitive dynamics of perspective-taking
Publication date: February 2019Source: Journal of Memory and Language, Volume 104Author(s): Alexia Galati, Rick Dale, Nicholas D. DuranAbstractHow do environmental cues and social perspectives influence perspective selection? Listeners responded to instructions (e.g., "Give me the folder on the right") from a simulated partner, selecting from two objects consistently aligned with themselves (ego-aligned; Experiment 1a) or the speaker (other-aligned; Experiment1b). In Experiment 2, listeners selected from triangular 3-object configurations whose orientation varied (ego-, other-, or neither-aligned). When the configural cue was other-aligned (consistently or inconsistently: Experiments 1b and 2), listeners were more likely to be other-centric. Other-centric responders stabilized their st...
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A biotin receptor-targeted silicon(IV) phthalocyanine for in vivo tumor imaging and photodynamic therapy
Publication date: Available online 15 September 2018Source: Journal of Photochemistry and Photobiology B: BiologyAuthor(s): Ke Li, Wenyi Dong, Qingzhu Liu, Gaochao Lv, Minhao Xie, Xinchen Sun, Ling Qiu, Jianguo LinAbstractPhthalocyanines (Pcs) are a kind of potential photosensitizers for fluorescence imaging and photodynamic therapy (PDT). However, the clinical application of Pcs is suffered from their poor solubility, high aggregation tendency and low tumor-specificity. To address these problems, two biotin moieties were linked to the axial positions of silicon(IV) phthalocyanine (SiPc) through hydrophilic polyethylene glycol (PEG) linkers to synthesize a new water-soluble and tumor-targeting photosensitizer (compound 1). The introduction of PEG linkers on SiPc markedly reduced the aggreg...
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On the neural basis of word reading: A meta-analysis of fMRI evidence using activation likelihood estimation
Publication date: February 2019Source: Journal of Neurolinguistics, Volume 49Author(s): K.A. Murphy, J. Jogia, J.B. TalcottAbstractThe neural networks that support normal single word reading have been studied extensively with functional magnetic resonance imaging (fMRI) and been heavily meta analysed; yet two caveats persist. Firstly, inclusion criteria are generally broad, allowing for a range of studies with inconsistent methodological practices to become a major source of variance in the data. Secondly, the sophistication of meta analytic techniques are ever improving, calling for a continuation of quantitative summaries for more informed interpretations of the literature. We conducted a novel meta-analysis using the updated activation likelihood estimation (ALE) approach on fMRI data f...
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Parent-rating vs performance-based working memory measures: Association with spoken language measures in school-age children.
Authors: Magimairaj BM Abstract Working memory (WM) assessment is often part of cognitive-linguistic test batteries. The author examined the relationship between parent rating of WM functioning and children's performance-based WM, and the relationship of each with receptive and expressive spoken language measures. Study participants were eighty-three 7- to 11-year-old children. The sample represented a broad range of cognitive abilities. No participating child had frank neurological or intellectual disabilities, autism, fluency disorder, or hearing loss. Parents completed a standardized executive function rating scale that included a WM subscale. Children completed a standardized WM task and an experimental WM task. Children also completed six standardized language measures. Result...
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From vaccines to global health to vaccines
. (Source: Human Vaccines and Immunotherapeutics)
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The structure of situation models as revealed by anaphor resolution
Publication date: Available online 14 September 2018Source: Language SciencesAuthor(s): Sashank Varma, Amanda JanssenAbstractThis paper investigates the structure of situation models as revealed by the process of anaphor resolution. The situation model for a text combines the meanings of its individual sentences with inferences generated from prior knowledge into an overall understanding of the text. We conceptualize situation models as implemented by collections of traces in episodic long-term memory that are retrieved based on their similarity to cues in working memory. Traces encode both contextual (i.e., spatial and temporal) and semantic information, providing structure to situation models. Four predictions were derived regarding the retrieval of antecedent traces during anaphor resol...
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Is there a pluralia tantum subcategory of nominal gerunds? Developing Gaeta's notion of morphological differentiation
Publication date: Available online 14 September 2018Source: Language SciencesAuthor(s): J. Lachlan MackenzieAbstractInspired by Gaeta's study of morphological distinctiveness as the basis for category formation, this article considers the possibility that by virtue of their invariable suffix -ings English pluralia tantum nominal gerunds (PTNGs) such as surroundings can be regarded as a subcategory of nominal gerunds. It is shown that the set of PTNGs is semantically very disparate with regard to the verb that underwent nominalization in the course of their formation. Differences are observed in a very large corpus with regard to the quantifiers and other items that co-occur with PTNGs, namely quantifiers regularly associated with plural count (e.g. many) or with mass nouns (e.g. much), but...
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A game of give and take: category change on the border between adverbial verbal gerunds and augmented absolutes in English
This article discusses one of several reasons for the loss of augmentation in English absolute constructions (ACs): the emergence of the verbal gerund (VG) in -ing. The VG was from the start strongly associated with prepositional contexts (de Smet, 2008) and has been shown to have a history connected to the AC (Fanego, 2004). More specifically, the strong association between VGs and prepositions probably caused a reinterpretation of most prepositionally augmented ACs as VGs, resulting in a functional split (Fonteyn & van de Pol, 2016). Second, this paper illustrates how the what with-construction underwent a very similar development, albeit in the opposite direction. Indeed, it appears that the grammaticalization of with into an AC-marker (van de Pol & Hoffmann, 2016), and the resulting st...
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Green biosynthesis of silver nanoparticles produced from marine Streptomyces sp. Al-Dhabi-89 and their potential applications against wound infection and drug resistant clinical pathogens
In conclusion, the silver nanoparticles produced from marine Streptomyces sp. Al-Dhabi-89 exhibited potential activity against both standard and clinical drug resistant microbial pathogens.Graphical Abstract (Source: Journal of Photochemistry and Photobiology B: Biology)
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Social and configural effects on the cognitive dynamics of perspective-taking
Publication date: February 2019Source: Journal of Memory and Language, Volume 104Author(s): Alexia Galati, Rick Dale, Nicholas D. DuranAbstractHow do environmental cues and social perspectives influence perspective selection? Listeners responded to instructions (e.g., "Give me the folder on the right") from a simulated partner, selecting from two objects consistently aligned with themselves (ego-aligned; Experiment 1a) or the speaker (other-aligned; Experiment1b). In Experiment 2, listeners selected from triangular 3-object configurations whose orientation varied (ego-, other-, or neither-aligned). When the configural cue was other-aligned (consistently or inconsistently: Experiments 1b and 2), listeners were more likely to be other-centric. Other-centric responders stabilized their st...
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A biotin receptor-targeted silicon(IV) phthalocyanine for in vivo tumor imaging and photodynamic therapy
Publication date: Available online 15 September 2018Source: Journal of Photochemistry and Photobiology B: BiologyAuthor(s): Ke Li, Wenyi Dong, Qingzhu Liu, Gaochao Lv, Minhao Xie, Xinchen Sun, Ling Qiu, Jianguo LinAbstractPhthalocyanines (Pcs) are a kind of potential photosensitizers for fluorescence imaging and photodynamic therapy (PDT). However, the clinical application of Pcs is suffered from their poor solubility, high aggregation tendency and low tumor-specificity. To address these problems, two biotin moieties were linked to the axial positions of silicon(IV) phthalocyanine (SiPc) through hydrophilic polyethylene glycol (PEG) linkers to synthesize a new water-soluble and tumor-targeting photosensitizer (compound 1). The introduction of PEG linkers on SiPc markedly reduced the aggreg...
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Parent-rating vs performance-based working memory measures: Association with spoken language measures in school-age children.
Authors: Magimairaj BM Abstract Working memory (WM) assessment is often part of cognitive-linguistic test batteries. The author examined the relationship between parent rating of WM functioning and children's performance-based WM, and the relationship of each with receptive and expressive spoken language measures. Study participants were eighty-three 7- to 11-year-old children. The sample represented a broad range of cognitive abilities. No participating child had frank neurological or intellectual disabilities, autism, fluency disorder, or hearing loss. Parents completed a standardized executive function rating scale that included a WM subscale. Children completed a standardized WM task and an experimental WM task. Children also completed six standardized language measures. Result...
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Machine Learning-based Self-powered Acoustic Sensor for Speaker Recognition
Publication date: Available online 14 September 2018Source: Nano EnergyAuthor(s): Jae Hyun Han, Kang Min Bae, Seong Kwang Hong, Hyunsin Park, Jun-Hyuk Kwak, Hee Seung Wang, Daniel Juhyung Joe, Jung Hwan Park, Young Hoon Jung, Shin Hur, Chang D. Yoo, Keon Jae LeeAbstractHerein, we report a new platform of machine learning-based speaker recognition via the flexible piezoelectric acoustic sensor (f-PAS) with a highly sensitive multi-resonant frequency band. The resonant self-powered f-PAS was fabricated by mimicking the operating mechanism of the basilar membrane in the human cochlear. The f-PAS acquired abundant voice information from the multi-channel sound inputs. The standard TIDIGITS dataset were recorded by the f-PAS and converted to frequency components by using a Fast Fourier Transfor...
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Investigation of cochlear hair cells and the perception of ultrasound signals in guinea pigs.
Authors: Wang FS, Nie G, Huang CC, Li Q, Li T, Zou Y, Zhang S, Ceng X Abstract We established a specific ultrasound frequency-dependent model of cochlear injury using bone conduction ultrasounds in the inner ear of guinea pigs at 50 kHz and 83 kHz, to explore the effects of bone conduction ultrasound in the cochlea. To establish a unilateral cochlear damage model, the unilateral cochlea was destroyed. The control group consisted of 50 kHz and 83 kHz bone conduction ultrasounds in unaltered guinea pigs. In each group, cerebral blood oxygenation level dependent (BOLD) effects were determined by functional magnetic resonance imaging (fMRI). The cochlear outer hair cell motor protein, Prestin, and the microfilament protein, F-Actin, were detected. We found that bone conduction ultrasou...
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The Tip of the Iceberg in Maternally Inherited Diabetes and Deafness.
We report a single case of a patient with MIDD which manifested clinically at 41 years old. In addition to diabetes and deafness, he manifested with seizures, ataxia, myopathy, and hypogonadism. We used established methods for the routine workup of this patient. MIDD is indeed a multisystem condition. A previously undescribed phenotypic feature of MIDD may be hypogonadism. PMID: 30210725 [PubMed] (Source: Oman Medical Journal)
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Machine Learning-based Self-powered Acoustic Sensor for Speaker Recognition
Publication date: Available online 14 September 2018Source: Nano EnergyAuthor(s): Jae Hyun Han, Kang Min Bae, Seong Kwang Hong, Hyunsin Park, Jun-Hyuk Kwak, Hee Seung Wang, Daniel Juhyung Joe, Jung Hwan Park, Young Hoon Jung, Shin Hur, Chang D. Yoo, Keon Jae LeeAbstractHerein, we report a new platform of machine learning-based speaker recognition via the flexible piezoelectric acoustic sensor (f-PAS) with a highly sensitive multi-resonant frequency band. The resonant self-powered f-PAS was fabricated by mimicking the operating mechanism of the basilar membrane in the human cochlear. The f-PAS acquired abundant voice information from the multi-channel sound inputs. The standard TIDIGITS dataset were recorded by the f-PAS and converted to frequency components by using a Fast Fourier Transfor...
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Investigation of cochlear hair cells and the perception of ultrasound signals in guinea pigs.
Authors: Wang FS, Nie G, Huang CC, Li Q, Li T, Zou Y, Zhang S, Ceng X Abstract We established a specific ultrasound frequency-dependent model of cochlear injury using bone conduction ultrasounds in the inner ear of guinea pigs at 50 kHz and 83 kHz, to explore the effects of bone conduction ultrasound in the cochlea. To establish a unilateral cochlear damage model, the unilateral cochlea was destroyed. The control group consisted of 50 kHz and 83 kHz bone conduction ultrasounds in unaltered guinea pigs. In each group, cerebral blood oxygenation level dependent (BOLD) effects were determined by functional magnetic resonance imaging (fMRI). The cochlear outer hair cell motor protein, Prestin, and the microfilament protein, F-Actin, were detected. We found that bone conduction ultrasou...
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The Tip of the Iceberg in Maternally Inherited Diabetes and Deafness.
We report a single case of a patient with MIDD which manifested clinically at 41 years old. In addition to diabetes and deafness, he manifested with seizures, ataxia, myopathy, and hypogonadism. We used established methods for the routine workup of this patient. MIDD is indeed a multisystem condition. A previously undescribed phenotypic feature of MIDD may be hypogonadism. PMID: 30210725 [PubMed] (Source: Oman Medical Journal)
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Acute Unilateral Isolated Oculomotor Nerve Palsy in an Adult Patient with Influenza A.
Authors: Senda J, Araki K, Tachi Y, Watanabe H, Kagawashira Y, Ito M, Atsuta N, Katsuno M, Watanabe H, Sobue G Abstract An otherwise healthy 44-year-old woman exhibited isolated unilateral oculomotor nerve palsy accompanied by an influenza A infection. An intra-orbital MRI scan revealed that her right third intracranial nerve was enlarged and enhanced. She recovered completely during the first month after treatment with oseltamivir phosphate. Although intracranial nerve disorders that result from influenza infections are most frequently reported in children, it is noteworthy that influenza can also cause focal intracranial nerve inflammation with ophthalmoparesis in adults. These disorders can be diagnosed using intra-orbital MRI scans with appropriate sequences and through immunol...
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Acute Unilateral Isolated Oculomotor Nerve Palsy in an Adult Patient with Influenza A.
Authors: Senda J, Araki K, Tachi Y, Watanabe H, Kagawashira Y, Ito M, Atsuta N, Katsuno M, Watanabe H, Sobue G Abstract An otherwise healthy 44-year-old woman exhibited isolated unilateral oculomotor nerve palsy accompanied by an influenza A infection. An intra-orbital MRI scan revealed that her right third intracranial nerve was enlarged and enhanced. She recovered completely during the first month after treatment with oseltamivir phosphate. Although intracranial nerve disorders that result from influenza infections are most frequently reported in children, it is noteworthy that influenza can also cause focal intracranial nerve inflammation with ophthalmoparesis in adults. These disorders can be diagnosed using intra-orbital MRI scans with appropriate sequences and through immunol...
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Comparison of extrusion and patency of silicon versus thermoplastic elastomer tympanostomy tubes
This study aimed to assess the differences in the extrusion rate, patency and incidence of otorrhea according to the material properties of tubes in tympanostomy tube (TT) procedures.
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Comparison of extrusion and patency of silicon versus thermoplastic elastomer tympanostomy tubes
This study aimed to assess the differences in the extrusion rate, patency and incidence of otorrhea according to the material properties of tubes in tympanostomy tube (TT) procedures.
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Facial Palsy: Diagnostic and Therapeutic Management
Facial expression is an evolutionary adaption facilitating successful social interaction. Muscles of facial expression are pivotal to nonverbal communication, articulation, and corneal protection. Facial palsy results in functional, communicative, and social impairment with profound negative impact on quality of life and emotional well-being. Congenital absence or acute facial nerve insult results in flaccid paralysis. Ultimate recovery following facial nerve insult lies on a spectrum from persistence of dense paralysis to return of normal function; in between zonal permutations of varying degrees of static and kinetic hypoactivity and hyperactivity and synkinesis exist.
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You’re Never Fully Dressed Without a Smile
Whether we like it or not, judgments based on facial appearance play a powerful role in how we treat others and how we ourselves are treated. Psychologists have long known that attractive people achieve better outcomes in practically all walks of life. We have all heard, "You never get a second chance to make a first impression." What is striking is that the judgment during the first impression is made within 1/10th of one second.1
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Describing the mandible in patients with craniofacial microsomia based on principal component analysis and thin plate spline video analysis
Craniofacial microsomia (CFM) is most often described as a unilateral malformation of derivatives of the first and second branchial arches. The mandible has been classified using several classification systems. However, all are based on two-dimensional imaging. The aim of this study was to mathematically describe the deformed mandible based on principal component analysis (PCA) in a three-dimensional way. This may aid in defining the flaws in existing surgical corrections of the mandible through the identification of the differences in shape compared with a normal mandible in a holistic view with the help of videos.
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Describing the mandible in patients with craniofacial microsomia based on principal component analysis and thin plate spline video analysis
Craniofacial microsomia (CFM) is most often described as a unilateral malformation of derivatives of the first and second branchial arches. The mandible has been classified using several classification systems. However, all are based on two-dimensional imaging. The aim of this study was to mathematically describe the deformed mandible based on principal component analysis (PCA) in a three-dimensional way. This may aid in defining the flaws in existing surgical corrections of the mandible through the identification of the differences in shape compared with a normal mandible in a holistic view with the help of videos.
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Head And Neck Cancer Treatment Market Promising regions, Revenue, Share, Sales and Growth Rate Forecast to 2021
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Head And Neck Cancer Treatment Market Promising regions, Revenue, Share, Sales and Growth Rate Forecast to 2021
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Head and Neck Cancer Treatment Market Overview, Size,Revenue, Demand, End Users, Research Finding by 2017 ...
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Look for Early Signs of Thyroid Cancer, Experts Urge
| Look for Early Signs of Thyroid Cancer, Experts Urge U.S. News & World ReportFull coverage |
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Look for Early Signs of Thyroid Cancer, Experts Urge
| Look for Early Signs of Thyroid Cancer, Experts Urge U.S. News & World ReportFull coverage |
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Head and Neck Cancer Treatment Market Overview, Size,Revenue, Demand, End Users, Research Finding by 2017 ...
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Head and Neck Cancer Treatment Market Overview, Size,Revenue, Demand, End Users, Research Finding by 2017 ...
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Survey of Toxoplasma gondii and Neospora caninum in raccoons (Procyon lotor) from the Czech Republic, Germany and Poland
Publication date: Available online 14 September 2018Source: Veterinary ParasitologyAuthor(s): Aleksandra Kornacka, Aleksandra Cybulska, Marcin Popiołek, Bożena MoskwaAbstractThe studies were carried on raccoons from Poland, Germany and the Czech Republic. Tissue samples from raccoon hearts, lungs and brains were used for molecular examination while meat juice was collected for immunological tests.Antibodies against T. gondii were detected in six out of 44 raccoons (13.6%), while T. gondii DNA was found in 18 (40.9%). Antibodies against N. caninum were found in seven raccoons (15.9%) but no parasite DNA was observed in any sample.DNA of T. gondii was observed in raccoons of both sexes (in 42.3% of females and 38.9% of males) from all three countries. The proportion of raccoons that tested...
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Prevalence and molecular characteristics of methicillin-resistant Staphylococcus aureus among nasal carriage strains isolated from emergency department patients and healthcare workers in central Taiwan
ConclusionOverall, a substantial proportion of patients visiting the ED and HCWs harbored CA-MRSA, mostly ST59 strains, in their nares. It is noteworthy that MRSA ST45 strains supplanted ST239 as the second leading nasal MRSA colonization strain in our study. (Source: Journal of Microbiology, Immunology and Infection)
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Survey of Toxoplasma gondii and Neospora caninum in raccoons (Procyon lotor) from the Czech Republic, Germany and Poland
Publication date: Available online 14 September 2018Source: Veterinary ParasitologyAuthor(s): Aleksandra Kornacka, Aleksandra Cybulska, Marcin Popiołek, Bożena MoskwaAbstractThe studies were carried on raccoons from Poland, Germany and the Czech Republic. Tissue samples from raccoon hearts, lungs and brains were used for molecular examination while meat juice was collected for immunological tests.Antibodies against T. gondii were detected in six out of 44 raccoons (13.6%), while T. gondii DNA was found in 18 (40.9%). Antibodies against N. caninum were found in seven raccoons (15.9%) but no parasite DNA was observed in any sample.DNA of T. gondii was observed in raccoons of both sexes (in 42.3% of females and 38.9% of males) from all three countries. The proportion of raccoons that tested...
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Prevalence and molecular characteristics of methicillin-resistant Staphylococcus aureus among nasal carriage strains isolated from emergency department patients and healthcare workers in central Taiwan
ConclusionOverall, a substantial proportion of patients visiting the ED and HCWs harbored CA-MRSA, mostly ST59 strains, in their nares. It is noteworthy that MRSA ST45 strains supplanted ST239 as the second leading nasal MRSA colonization strain in our study. (Source: Journal of Microbiology, Immunology and Infection)
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Head And Neck Cancer Treatment Market Analysis, Overview, Growth, Share, Demand and Forecast Research Report ...
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Head And Neck Cancer Treatment Market Promising regions, Revenue, Share, Sales and Growth Rate Forecast to 2021
| Head And Neck Cancer Treatment Market Promising regions, Revenue, Share, Sales and Growth Rate Forecast to 2021 IDA ReportFull coverage |
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Head And Neck Cancer Treatment Market Analysis, Overview, Growth, Share, Demand and Forecast Research Report ...
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Head And Neck Cancer Treatment Market Promising regions, Revenue, Share, Sales and Growth Rate Forecast to 2021
| Head And Neck Cancer Treatment Market Promising regions, Revenue, Share, Sales and Growth Rate Forecast to 2021 IDA ReportFull coverage |
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Mucosal immune parameters, immune and antioxidant defence related genes expression and growth performance of zebrafish (Danio rerio) fed on Gracilaria gracilis powder
Publication date: Available online 14 September 2018Source: Fish & Shellfish ImmunologyAuthor(s): Seyed Hossein Hoseinifar, Samira Yousefi, Gioele Capillo, Hamed Paknejad, Mohsen Khalili, Alijan Tabarraei, Hien Van Doan, Nunziacarla Spanò, Caterina FaggioAbstractIn the present study zebrafish (Danio rerio) has been used as model organism to establish the effects of dietary supplementation of Gracilaria gracilis powder (GP) on mucosal and innate immune parameters, antioxidant enzymes, and growth. In order to establish these features, zebrafish were fed for eight weeks with experimental diets containing different levels of Red algae, 0.25, 0.5 and 1% of GP; also, a group was fed with control diet. At the end of the experimental period the antioxidant superoxide dismutase and catalase (SOD, ...
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Prognosticating Outcomes in Interstitial Lung Disease by Mediastinal Lymph Node Assessment: An Observational Cohort Study with Independent Validation.
CONCLUSIONS: MLN enlargement predicts TFS and hospitalization risk in ILD, and is associated with decreased levels of a key circulating cytokine sCD40L. Incorporating MLN and cytokine findings into current prediction models might improve ILD prognostication. PMID: 30216085 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
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Mucosal immune parameters, immune and antioxidant defence related genes expression and growth performance of zebrafish (Danio rerio) fed on Gracilaria gracilis powder
Publication date: Available online 14 September 2018Source: Fish & Shellfish ImmunologyAuthor(s): Seyed Hossein Hoseinifar, Samira Yousefi, Gioele Capillo, Hamed Paknejad, Mohsen Khalili, Alijan Tabarraei, Hien Van Doan, Nunziacarla Spanò, Caterina FaggioAbstractIn the present study zebrafish (Danio rerio) has been used as model organism to establish the effects of dietary supplementation of Gracilaria gracilis powder (GP) on mucosal and innate immune parameters, antioxidant enzymes, and growth. In order to establish these features, zebrafish were fed for eight weeks with experimental diets containing different levels of Red algae, 0.25, 0.5 and 1% of GP; also, a group was fed with control diet. At the end of the experimental period the antioxidant superoxide dismutase and catalase (SOD, ...
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Prognosticating Outcomes in Interstitial Lung Disease by Mediastinal Lymph Node Assessment: An Observational Cohort Study with Independent Validation.
CONCLUSIONS: MLN enlargement predicts TFS and hospitalization risk in ILD, and is associated with decreased levels of a key circulating cytokine sCD40L. Incorporating MLN and cytokine findings into current prediction models might improve ILD prognostication. PMID: 30216085 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
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Woman battling cancer to receive bone marrow transplant from her 14-year-old daughter
| Woman battling cancer to receive bone marrow transplant from her 14-year-old daughter KXLH Helena NewsFull coverage |
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Woman battling cancer to receive bone marrow transplant from her 14-year-old daughter
| Woman battling cancer to receive bone marrow transplant from her 14-year-old daughter KXLH Helena NewsFull coverage |
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Zinc supplementation plays a crucial role in T helper 9 differentiation in allogeneic immune reactions and non-activated T cells
Publication date: Available online 6 February 2018Source: Journal of Trace Elements in Medicine and BiologyAuthor(s): Martina Maywald, Fudi Wang, Lothar RinkAbstractT helper (Th) 9 cells play a critical role in immune-mediated diseases, including allergic airway inflammation, autoimmune diseases, and cancer development. Thus, the promotion or suppression of Th9 cell differentiation, transcriptional control, and function is very important for a healthy immune system. Interestingly, T cell maturation, differentiation and function are highly dependent on the individuals' zinc status. This is especially seen in zinc deficient individuals as in the elderly population often suffering of autoimmunity and increased incidence of infections.In this regard, this study examines the impact of zinc su...
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A pilot study on adjunctive use of parametric colour-coded digital subtraction angiography in endovascular interventions of haemodialysis access
Abstract
Background
Two-dimensional digital subtraction angiography (DSA) is the gold standard for angiographic evaluation of dysfunctional haemodialysis access. We aim to investigate the utility of parametric colour coded DSA in providing hemodynamic analysis during haemodialysis access interventions.
Methods
We retrospectively studied 20 patients who underwent access intervention and applied parametric colour-coding on selected DSA acquisitions before and after percutaneous transluminal angioplasty (PTA). The difference in time to peak (dTTP) contrast enhancement and time attenuation curve (TAC) of pre- and post-stenotic regions of interest (ROIs) were obtained and compared after treatment.
Results
Improvements were seen in mean percent of stenosis after PTA (p < 0.0001) for all cases. Median dTTP improved from 0.52 (IQR 0.26, 0.8) to 0.25 (IQR 0, 0.26) seconds (p = 0.001). Median 50% contrast washout time improved from 0.77 (IQR 0.39, 1.17) to 0.42 (IQR 0.23, 0.59) seconds (p = 0.031). Significant correlation was seen for dTTP vs. percent of stenosis (r = 0.723, p = 0.043) pre-PTA and for change in dTTP vs. percent change in stenosis post-PTA (r = 0.786, p = 0.021) for inflow lesions. Such correlation was however not seen in outflow lesions.
Conclusions
Adjunctive use of parametric colour-coded DSA may provide potentially useful hemodynamic information during vascular access interventions. Larger prospective studies are needed to validate our findings.
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Zinc supplementation plays a crucial role in T helper 9 differentiation in allogeneic immune reactions and non-activated T cells
Publication date: Available online 6 February 2018Source: Journal of Trace Elements in Medicine and BiologyAuthor(s): Martina Maywald, Fudi Wang, Lothar RinkAbstractT helper (Th) 9 cells play a critical role in immune-mediated diseases, including allergic airway inflammation, autoimmune diseases, and cancer development. Thus, the promotion or suppression of Th9 cell differentiation, transcriptional control, and function is very important for a healthy immune system. Interestingly, T cell maturation, differentiation and function are highly dependent on the individuals' zinc status. This is especially seen in zinc deficient individuals as in the elderly population often suffering of autoimmunity and increased incidence of infections.In this regard, this study examines the impact of zinc su...
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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2pcUfSt
A pilot study on adjunctive use of parametric colour-coded digital subtraction angiography in endovascular interventions of haemodialysis access
Abstract
Background
Two-dimensional digital subtraction angiography (DSA) is the gold standard for angiographic evaluation of dysfunctional haemodialysis access. We aim to investigate the utility of parametric colour coded DSA in providing hemodynamic analysis during haemodialysis access interventions.
Methods
We retrospectively studied 20 patients who underwent access intervention and applied parametric colour-coding on selected DSA acquisitions before and after percutaneous transluminal angioplasty (PTA). The difference in time to peak (dTTP) contrast enhancement and time attenuation curve (TAC) of pre- and post-stenotic regions of interest (ROIs) were obtained and compared after treatment.
Results
Improvements were seen in mean percent of stenosis after PTA (p < 0.0001) for all cases. Median dTTP improved from 0.52 (IQR 0.26, 0.8) to 0.25 (IQR 0, 0.26) seconds (p = 0.001). Median 50% contrast washout time improved from 0.77 (IQR 0.39, 1.17) to 0.42 (IQR 0.23, 0.59) seconds (p = 0.031). Significant correlation was seen for dTTP vs. percent of stenosis (r = 0.723, p = 0.043) pre-PTA and for change in dTTP vs. percent change in stenosis post-PTA (r = 0.786, p = 0.021) for inflow lesions. Such correlation was however not seen in outflow lesions.
Conclusions
Adjunctive use of parametric colour-coded DSA may provide potentially useful hemodynamic information during vascular access interventions. Larger prospective studies are needed to validate our findings.
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Generosity and Duration of Medicaid Expansion Waivers and Access to Care
Publication date: Available online 14 September 2018
Source: American Journal of Preventive Medicine
Author(s): Wafa W. Tarazi, Cathy J. Bradley, David W. Harless, Harry D. Bear, Lindsay M. Sabik
Introduction
Prior to expansion of Medicaid under the Affordable Care Act, some states obtained Section 1115 waivers from the federal government that allowed them to expand eligibility for Medicaid to adult populations that were not covered previously. Expansion waivers in these states differed in their generosity and year of implementation, creating variation in coverage availability and program longevity across states. This study examined the association between generosity and duration of Medicaid expansion waivers and access to preventive services.
Methods
The 2012 Medical Expenditure Panel Survey data were used to estimate adjusted logistic models in 2016, comparing outcomes among low-income non-elderly adults living in generous (Medicaid eligibility threshold ≥138% federal poverty level) and moderate (Medicaid eligibility threshold <138% federal poverty level) waiver states, relative to no-waiver states.
Results
Moderate and generous waivers were associated with statistically significant (p<0.001) increases in probabilities of having a usual source of care and a blood pressure check, relative to states without a waiver to expand. Low-income individuals living in states with longer waiver durations had better access to healthcare services than a similar group living in comparison states.
Conclusions
Not only is Medicaid waiver generosity associated with improving access to healthcare services, but the combination of generosity and longer duration of a waiver also intensifies the association. As states gain flexibility in designing their Medicaid programs, the healthcare benefits associated with both generosity and duration of waivers are important considerations for policy makers.
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Reassessing Urban Health Interventions: Back to the Future with Google Street View Time Machine
Publication date: Available online 14 September 2018
Source: American Journal of Preventive Medicine
Author(s): Ronaldo L. Cândido, Madeleine Steinmetz-Wood, Patrick Morency, Yan Kestens
Introduction
Validity of research linking built environments to health relies on the availability and reliability of data used to measure exposures. As cities transform, it is important to track when and where urban changes occur, to provide detailed information for urban health intervention research. This paper presents an online observation method of the implementation of traffic-calmingfeatures using Google Street View Time Machine. The method is used to validate an existingadministrative database detailing the implementation of curb extensions and speed bumps.
Methods
Online observation of curb extensions and speed bumps was conducted for four boroughsin Montreal, Canada, in autumn 2016, and compared with administrative data documenting traffic-calming measures implemented between 2008 and 2014. All images available through the Time Machine function between 2007 and 2016 for 708 intervention sites were visualized online. Records in the administrative database were compared to real-world Google Street View observations and tested in terms of sensitivity, specificity, and positive predicted value.
Results
Google Street View Time Machine allowed the visualization of a median of seven different dates per street intersection and six dates per street segment. This made it possible to analyze built environment changes within 3,973 distinct time periods at 708 locations. Validation of the administrative data regarding presence of an intervention showed 99% (95% CI=97%, 99%) sensitivity, 58% (95% CI=51%, 64%) specificity, and 77% (95% CI=73%, 81%) positive predictive value.
Conclusions
Google Street View Time Machine allowed past (2007–2016) online documentation of microscale urban interventions—curb extensions and speed bumps. The proposed method offers a new way to document historic changes to the built environment, which will be useful for urban health intervention research.
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Generosity and Duration of Medicaid Expansion Waivers and Access to Care
Publication date: Available online 14 September 2018
Source: American Journal of Preventive Medicine
Author(s): Wafa W. Tarazi, Cathy J. Bradley, David W. Harless, Harry D. Bear, Lindsay M. Sabik
Introduction
Prior to expansion of Medicaid under the Affordable Care Act, some states obtained Section 1115 waivers from the federal government that allowed them to expand eligibility for Medicaid to adult populations that were not covered previously. Expansion waivers in these states differed in their generosity and year of implementation, creating variation in coverage availability and program longevity across states. This study examined the association between generosity and duration of Medicaid expansion waivers and access to preventive services.
Methods
The 2012 Medical Expenditure Panel Survey data were used to estimate adjusted logistic models in 2016, comparing outcomes among low-income non-elderly adults living in generous (Medicaid eligibility threshold ≥138% federal poverty level) and moderate (Medicaid eligibility threshold <138% federal poverty level) waiver states, relative to no-waiver states.
Results
Moderate and generous waivers were associated with statistically significant (p<0.001) increases in probabilities of having a usual source of care and a blood pressure check, relative to states without a waiver to expand. Low-income individuals living in states with longer waiver durations had better access to healthcare services than a similar group living in comparison states.
Conclusions
Not only is Medicaid waiver generosity associated with improving access to healthcare services, but the combination of generosity and longer duration of a waiver also intensifies the association. As states gain flexibility in designing their Medicaid programs, the healthcare benefits associated with both generosity and duration of waivers are important considerations for policy makers.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2QyIJ0q
Reassessing Urban Health Interventions: Back to the Future with Google Street View Time Machine
Publication date: Available online 14 September 2018
Source: American Journal of Preventive Medicine
Author(s): Ronaldo L. Cândido, Madeleine Steinmetz-Wood, Patrick Morency, Yan Kestens
Introduction
Validity of research linking built environments to health relies on the availability and reliability of data used to measure exposures. As cities transform, it is important to track when and where urban changes occur, to provide detailed information for urban health intervention research. This paper presents an online observation method of the implementation of traffic-calmingfeatures using Google Street View Time Machine. The method is used to validate an existingadministrative database detailing the implementation of curb extensions and speed bumps.
Methods
Online observation of curb extensions and speed bumps was conducted for four boroughsin Montreal, Canada, in autumn 2016, and compared with administrative data documenting traffic-calming measures implemented between 2008 and 2014. All images available through the Time Machine function between 2007 and 2016 for 708 intervention sites were visualized online. Records in the administrative database were compared to real-world Google Street View observations and tested in terms of sensitivity, specificity, and positive predicted value.
Results
Google Street View Time Machine allowed the visualization of a median of seven different dates per street intersection and six dates per street segment. This made it possible to analyze built environment changes within 3,973 distinct time periods at 708 locations. Validation of the administrative data regarding presence of an intervention showed 99% (95% CI=97%, 99%) sensitivity, 58% (95% CI=51%, 64%) specificity, and 77% (95% CI=73%, 81%) positive predictive value.
Conclusions
Google Street View Time Machine allowed past (2007–2016) online documentation of microscale urban interventions—curb extensions and speed bumps. The proposed method offers a new way to document historic changes to the built environment, which will be useful for urban health intervention research.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2D0Q9qn
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