Σάββατο 15 Σεπτεμβρίου 2018

A biotin receptor-targeted silicon(IV) phthalocyanine for in vivo tumor imaging and photodynamic therapy

Publication date: Available online 15 September 2018Source: Journal of Photochemistry and Photobiology B: BiologyAuthor(s): Ke Li, Wenyi Dong, Qingzhu Liu, Gaochao Lv, Minhao Xie, Xinchen Sun, Ling Qiu, Jianguo LinAbstractPhthalocyanines (Pcs) are a kind of potential photosensitizers for fluorescence imaging and photodynamic therapy (PDT). However, the clinical application of Pcs is suffered from their poor solubility, high aggregation tendency and low tumor-specificity. To address these problems, two biotin moieties were linked to the axial positions of silicon(IV) phthalocyanine (SiPc) through hydrophilic polyethylene glycol (PEG) linkers to synthesize a new water-soluble and tumor-targeting photosensitizer (compound 1). The introduction of PEG linkers on SiPc markedly reduced the aggreg...

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