Dual-energy computed tomography for prediction of loco-regional recurrence after radiotherapy in larynx and ...

Dual-energy computed tomography for prediction of loco-regional recurrence after radiotherapy in larynx and ...  MD LinxFull coverage

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Dual-energy computed tomography for prediction of loco-regional recurrence after radiotherapy in larynx and ...

Dual-energy computed tomography for prediction of loco-regional recurrence after radiotherapy in larynx and ...  MD LinxFull coverage

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Ask the Expert: How is new BEACON laser technology revolutionizing the field of complex head and neck surgeries at ...

Ask the Expert: How is new BEACON laser technology revolutionizing the field of complex head and neck surgeries at ...  New Jersey HeraldFull coverage

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Cochlear Implant Users ’ Vocal Control CorrelatesAcross Tasks

Cochlear implants (CIs) provide access to auditory information that can affect vocal control. For example, previous research shows that, when producing a sustained vowel, CI users will alter the pitch of their voice when the feedback of their own voice is perceived to shift. Although these results can be informative as to how perception and production are linked for CI users, the artificial nature of the task raises questions as to the applicability of the results to real-world vocal productions. (Source: Journal of Voice)

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Variation in bucco‐palatal maxillary sinus width does not permit a meaningful sinus classification

Abstract

Objectives

The bucco‐palatal sinus width (SW) appears as relevant factor for graft consolidation after maxillary sinus (MS) floor augmentation. The present study aimed to assess a) SW at different height levels of posterior teeth, b) possible factors influencing SW, and c) whether a simple/meaningful sinus classification based on SW is possible.

Methods

The following parameters were recorded on computed tomographies of 76 edentulous and 86 partially edentulous maxillary quadrants displaying 383 tooth sites in total: i) alveolar ridge height, ii) ‐area, iii) ‐width 2mm apical to the alveolar crest, iv) ‐width at the sinus floor, and v) SW and sinus area at a level 2, 4, 6, 8, and 10mm above the sinus floor. The possible influence of gender, tooth position [i.e., premolar (PM); molar (M)], tooth‐gap extent, and residual alveolar ridge dimensions on SW was assessed. Further, based on percentiles of average values or on the frequency distribution of SW <10, 10‐15, or >15mm, it was attempted to classify the sinus at each given site into narrow, average, or wide.

Results

Gender and tooth‐gap extent presented no relevant impact on MS dimensions; however, significant differences were observed among the various tooth positions regarding all evaluated parameters. The lower the residual alveolar ridge, the wider the MS at 4‐10mm height, while the wider the residual alveolar ridge, the wider the MS. Large variation in SW classes among the different height levels within the same tooth position and among tooth positions within the same person was observed, irrespective of the threshold applied. Further, at a MS height of 10mm at PM1, PM2, M1, and M2, SW was <10mm in 68%, 33%, 0%, and 7% of the cases, respectively, while in 3%, 21%, 65%, and 57%, respectively, SW was >15mm.

Conclusions

There is a large variation in SW depending on the height level within the sinus and on tooth position, which does not permit a simple/meaningful classification of each sinus as "narrow", "average", or "wide". Nevertheless, narrow sinuses (<10mm) are rather prevalent in the premolar region, while wide sinuses (>15mm) in the molar region; further, a wider and shorter residual alveolar ridge is associated with a wider SW.

This article is protected by copyright. All rights reserved.

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Cochlear Implant Users ’ Vocal Control CorrelatesAcross Tasks

Cochlear implants (CIs) provide access to auditory information that can affect vocal control. For example, previous research shows that, when producing a sustained vowel, CI users will alter the pitch of their voice when the feedback of their own voice is perceived to shift. Although these results can be informative as to how perception and production are linked for CI users, the artificial nature of the task raises questions as to the applicability of the results to real-world vocal productions. (Source: Journal of Voice)

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Variation in bucco‐palatal maxillary sinus width does not permit a meaningful sinus classification

Abstract

Objectives

The bucco‐palatal sinus width (SW) appears as relevant factor for graft consolidation after maxillary sinus (MS) floor augmentation. The present study aimed to assess a) SW at different height levels of posterior teeth, b) possible factors influencing SW, and c) whether a simple/meaningful sinus classification based on SW is possible.

Methods

The following parameters were recorded on computed tomographies of 76 edentulous and 86 partially edentulous maxillary quadrants displaying 383 tooth sites in total: i) alveolar ridge height, ii) ‐area, iii) ‐width 2mm apical to the alveolar crest, iv) ‐width at the sinus floor, and v) SW and sinus area at a level 2, 4, 6, 8, and 10mm above the sinus floor. The possible influence of gender, tooth position [i.e., premolar (PM); molar (M)], tooth‐gap extent, and residual alveolar ridge dimensions on SW was assessed. Further, based on percentiles of average values or on the frequency distribution of SW <10, 10‐15, or >15mm, it was attempted to classify the sinus at each given site into narrow, average, or wide.

Results

Gender and tooth‐gap extent presented no relevant impact on MS dimensions; however, significant differences were observed among the various tooth positions regarding all evaluated parameters. The lower the residual alveolar ridge, the wider the MS at 4‐10mm height, while the wider the residual alveolar ridge, the wider the MS. Large variation in SW classes among the different height levels within the same tooth position and among tooth positions within the same person was observed, irrespective of the threshold applied. Further, at a MS height of 10mm at PM1, PM2, M1, and M2, SW was <10mm in 68%, 33%, 0%, and 7% of the cases, respectively, while in 3%, 21%, 65%, and 57%, respectively, SW was >15mm.

Conclusions

There is a large variation in SW depending on the height level within the sinus and on tooth position, which does not permit a simple/meaningful classification of each sinus as "narrow", "average", or "wide". Nevertheless, narrow sinuses (<10mm) are rather prevalent in the premolar region, while wide sinuses (>15mm) in the molar region; further, a wider and shorter residual alveolar ridge is associated with a wider SW.

This article is protected by copyright. All rights reserved.

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Challenges in Optimizing Medical Education for Rheumatologists

The field of rheumatology has expanded rapidly in recent years, and innovations in immunology, epigenetics, and bone metabolism continue at an astonishing pace. In this fast changing field, optimizing medical education for rheumatologists is vital for maintaining a competent workforce to meet the needs of patients with rheumatic diseases. Several key challenges lie ahead and efforts to optimize medical education for rheumatologists are discussed in this article. (Source: Rheumatic Disease Clinics of North America)

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Challenges in Optimizing Medical Education for Rheumatologists

The field of rheumatology has expanded rapidly in recent years, and innovations in immunology, epigenetics, and bone metabolism continue at an astonishing pace. In this fast changing field, optimizing medical education for rheumatologists is vital for maintaining a competent workforce to meet the needs of patients with rheumatic diseases. Several key challenges lie ahead and efforts to optimize medical education for rheumatologists are discussed in this article. (Source: Rheumatic Disease Clinics of North America)

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SLP to Head of Arizona Department of Education

Democrat Kathy Hoffman, a speech-language pathologist in the Peoria (Arizona) Unified School District, won a tight race to become Arizona's superintendent of public instruction in the Nov. 4 election. The novice politician was declared the winner over Frank Riggs, an experienced politician, after a post-election vote count, according to a report on ABC15-Arizona. A first-time candidate, Hoffman won two political upsets—first by besting David Schapira, a veteran politician, in the Democratic primary over the summer, and then by narrowly overtaking Riggs, a former California congressman who also headed a nonprofit group that helped charter schools with funding. Hoffman, who will lead the Arizona Department of Education, was propelled by grassroots educators who took action during the #Re...

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SLP to Head of Arizona Department of Education

Democrat Kathy Hoffman, a speech-language pathologist in the Peoria (Arizona) Unified School District, won a tight race to become Arizona's superintendent of public instruction in the Nov. 4 election. The novice politician was declared the winner over Frank Riggs, an experienced politician, after a post-election vote count, according to a report on ABC15-Arizona. A first-time candidate, Hoffman won two political upsets—first by besting David Schapira, a veteran politician, in the Democratic primary over the summer, and then by narrowly overtaking Riggs, a former California congressman who also headed a nonprofit group that helped charter schools with funding. Hoffman, who will lead the Arizona Department of Education, was propelled by grassroots educators who took action during the #Re...

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Increased salivary AKR1B10 level: association with progression and poor prognosis of oral squamous cell carcinoma

Abstract

Background

Aldo‐keto reductase family 1 member B10 (AKR1B10) expression in oral squamous cell carcinoma (OSCC) tissue specimens is correlated with the progression and prognosis of OSCC.

Methods

Saliva samples were obtained from 35 normal controls and 86 patients with OSCC before cancer surgery. The AKR1B10 levels were determined using enzyme‐linked immunosorbent assay (ELISA).

Results

The mean salivary AKR1B10 levels were significantly higher in the patients with OSCC than in the normal controls (P < .001). Higher salivary AKR1B10 levels were significantly associated with larger tumor size, more advanced clinical stage, and areca quid chewing habit. Patients with OSCC with a higher salivary AKR1B10 level (>646 pg/mL) had a significantly poorer survival than those with a lower (≤646 pg/mL) salivary AKR1B10 level (P = .026).

Conclusion

The salivary AKR1B10 level may be a promising biomarker for screening high‐risk patients with OSCC and monitoring the progression of OSCC.

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Increased salivary AKR1B10 level: association with progression and poor prognosis of oral squamous cell carcinoma

Abstract

Background

Aldo‐keto reductase family 1 member B10 (AKR1B10) expression in oral squamous cell carcinoma (OSCC) tissue specimens is correlated with the progression and prognosis of OSCC.

Methods

Saliva samples were obtained from 35 normal controls and 86 patients with OSCC before cancer surgery. The AKR1B10 levels were determined using enzyme‐linked immunosorbent assay (ELISA).

Results

The mean salivary AKR1B10 levels were significantly higher in the patients with OSCC than in the normal controls (P < .001). Higher salivary AKR1B10 levels were significantly associated with larger tumor size, more advanced clinical stage, and areca quid chewing habit. Patients with OSCC with a higher salivary AKR1B10 level (>646 pg/mL) had a significantly poorer survival than those with a lower (≤646 pg/mL) salivary AKR1B10 level (P = .026).

Conclusion

The salivary AKR1B10 level may be a promising biomarker for screening high‐risk patients with OSCC and monitoring the progression of OSCC.

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Brain abnormalities in myalgic encephalomyelitis/chronic fatigue syndrome: Evaluation by diffusional kurtosis imaging and neurite orientation dispersion and density imaging

Background

Diffusional kurtosis imaging (DKI) and neurite orientation dispersion and density imaging (NODDI) metrics provide more specific information regarding pathological changes than diffusion tensor imaging (DTI).

Purpose

To detect microstructural abnormalities in myalgic encephalomyelitis (ME) / chronic fatigue syndrome (CFS) patients by using DKI and NODDI metrics.

Study Type

Prospective.

Population

Twenty ME/CFS patients and 23 healthy controls were recruited.

Field Strength/Sequence

Three‐b value DWI (b‐values = 0, 1000, and 2000 sec/mm²) and 3D T₁‐weighted images were at 3.0T.

Assessment

Mean kurtosis (MK), neurite density index (NDI), orientation dispersion index (ODI), fractional anisotropy (FA), and mean diffusivity (MD) were calculated.

Statistical Testing

The two‐sample t‐test analysis in SPM12 software was used to compare the differences between ME/CFS and control groups.

Results

In the ME/CFS patients, we observed significant FA decreases in the genu of the corpus callosum and the anterior limb of the right internal capsule (P < 0.05), but no significant difference in MD (P = 0.164); there were also significant MK decreases in the right frontal area, anterior cingulate gyrus, superior longitudinal fasciculus (SLF), and left parietal area (P < 0.05). Significant NDI decreases were observed in the right posterior cingulate gyrus, SLF, and left frontal area of the ME/CFS patients (P < 0.05). Significant ODI decreases were seen in the bilateral occipital areas, right superior temporal gyrus, the anterior limb of internal capsule, and the posterior cingulate gyrus (P < 0.05), and significant ODI increases were revealed in the bilateral occipital and right temporal areas (P < 0.05).

Data Conclusion

Right SLF abnormalities may be a diagnostic marker for ME/CFS.

Level of Evidence: 1

Technical Efficacy: Stage 2

J. Magn. Reson. Imaging 2018.

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A Triple‐Classification Radiomics Model for the Differentiation of Primary Chordoma, Giant Cell Tumor, and Metastatic Tumor of Sacrum Based on T2‐Weighted and Contrast‐Enhanced T1‐Weighted MRI

Background

Preoperative differentiation between primary sacral chordoma (SC), sacral giant cell tumor (SGCT), and sacral metastatic tumor (SMT) is important for treatment decisions.

Purpose

To develop and validate a triple‐classification radiomics model for the preoperative differentiation of SC, SGCT, and SMT based on T2‐weighted fat saturation (T2w FS) and contrast‐enhanced T1‐weighted (CE T1w) MRI.

Study type

Retrospective.

Population

A total of 120 pathologically confirmed sacral patients (54 SCs, 30 SGCTs, and 36 SMTs) were retrospectively analyzed and divided into a training set (n = 83) and a validation set (n = 37).

Field strength/sequence

The 3.0T axial T2w FS and CE T1w MRI.

Assessment

Morphology, intensity, and texture features were assessed based on Formfactor, Haralick, Gray‐level co‐occurrence matrix (GLCM), Gray‐level run‐length matrix (GLRLM), histogram.

Statistical tests

Analysis of variance, least absolute shrinkage and selection operator (LASSO), Pearson correlation, Random Forest (RF), area under the receiver operating characteristic curve (AUC) and accuracy analysis.

Results

The median age of SGCT (33.5, 25.3–45.5) was significantly lower than those of SC (58.0, 48.8–64.3) and SMT (59.0, 46.3–65.5) groups (χ² = 37.6; P < 0.05). No significant difference was found when compared in terms of genders, tumor locations, and tumor sizes of SC, SGCT, and SMT (; P1 = 0.15, P2 = 0.29, P3 = 0.06). For the differential value, features extracted from joint T2w FS and CE T1w images outperformed those from T2w FS or CE T1w images alone. Compared with CE T1w images, features derived from T2w FS images yielded higher AUC in both training and validating set. The best performance of radiomics model based on joint T2w FS and CE T1w images reached an AUC of 0.773, an accuracy of 0.711.

Data conclusion

Our 3.0T MRI‐based triple‐classification radiomics model is feasible to differentiate SC, SGCT, and SMT, which may be applied to improve the precision of preoperative diagnosis in clinical practice.

Level of Evidence: 4

Technical Efficacy: Stage 2

J. Magn. Reson. Imaging 2018.

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Accuracy and precision of proton density fat fraction measurement across field strengths and scan intervals: A phantom and human study

Background

Complex‐based chemical shift imaging‐based magnetic resonance imaging (CSE‐MRI) is emerging as a preferred method for noninvasively quantifying proton density fat fraction (PDFF), a promising quantitative imaging biomarker (QIB) for longitudinal hepatic steatosis measurement.

Purpose

To determine linearity, bias, repeatability, and reproducibility of the PDFF measurement using CSE‐MRI (CSE‐PDFF) across scan intervals, MR field strengths, and readers in phantom and nonalcoholic fatty liver disease (NAFLD) patients.

Study Type

Institutional Review Board (IRB)‐approved prospective.

Subjects

Fat‐water phantom and 20 adult patients.

Field Strength/Sequence

1.5 T and 3.0 T MR systems and a commercially available CSE‐MRI sequence (IDEAL‐IQ).

Assessment

Two independent readers measured CSE‐PDFF of fat‐water phantom and NAFLD patients across two field strengths and scan intervals (same‐day and 2‐week) each and in a combination of both. MR spectroscopy‐based PDFF (MRS‐PDFF) was used as the reference standard for phantom PDFF.

Statistical Tests

Linearity and bias of measurement were evaluated by linear regression analysis and Bland–Altman plots, respectively. Repeatability and reproducibility were assessed by coefficient of variance and repeatability / reproducibility coefficients (RC). The intraclass correlation coefficient was used to validate intra‐ and interobserver agreements.

Results

CSE‐PDFF showed high linearity and small bias (–0.6–0.4 PDFF%) with 95% limits of agreement within ±2.9 PDFF% across field strengths, 2‐week interscan period, and readers in the clinical scans. CSE‐PDFF was highly repeatable and reproducible both in phantom and clinical scans, with the largest observed RC across field strengths and 2‐week interscan period being 3 PDFF%.

Data Conclusion

CSE‐PDFF is a robust QIB with high linearity, small bias, and excellent repeatability/reproducibility. A change of more than 3 PDFF% across field strengths within 2 weeks of scan interval likely reflects a true change, which is well within the clinically acceptable range.

Level of Evidence: 3

Technical Efficacy: Stage 2

J. Magn. Reson. Imaging 2018.

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Brain abnormalities in myalgic encephalomyelitis/chronic fatigue syndrome: Evaluation by diffusional kurtosis imaging and neurite orientation dispersion and density imaging

Background

Diffusional kurtosis imaging (DKI) and neurite orientation dispersion and density imaging (NODDI) metrics provide more specific information regarding pathological changes than diffusion tensor imaging (DTI).

Purpose

To detect microstructural abnormalities in myalgic encephalomyelitis (ME) / chronic fatigue syndrome (CFS) patients by using DKI and NODDI metrics.

Study Type

Prospective.

Population

Twenty ME/CFS patients and 23 healthy controls were recruited.

Field Strength/Sequence

Three‐b value DWI (b‐values = 0, 1000, and 2000 sec/mm²) and 3D T₁‐weighted images were at 3.0T.

Assessment

Mean kurtosis (MK), neurite density index (NDI), orientation dispersion index (ODI), fractional anisotropy (FA), and mean diffusivity (MD) were calculated.

Statistical Testing

The two‐sample t‐test analysis in SPM12 software was used to compare the differences between ME/CFS and control groups.

Results

In the ME/CFS patients, we observed significant FA decreases in the genu of the corpus callosum and the anterior limb of the right internal capsule (P < 0.05), but no significant difference in MD (P = 0.164); there were also significant MK decreases in the right frontal area, anterior cingulate gyrus, superior longitudinal fasciculus (SLF), and left parietal area (P < 0.05). Significant NDI decreases were observed in the right posterior cingulate gyrus, SLF, and left frontal area of the ME/CFS patients (P < 0.05). Significant ODI decreases were seen in the bilateral occipital areas, right superior temporal gyrus, the anterior limb of internal capsule, and the posterior cingulate gyrus (P < 0.05), and significant ODI increases were revealed in the bilateral occipital and right temporal areas (P < 0.05).

Data Conclusion

Right SLF abnormalities may be a diagnostic marker for ME/CFS.

Level of Evidence: 1

Technical Efficacy: Stage 2

J. Magn. Reson. Imaging 2018.

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A Triple‐Classification Radiomics Model for the Differentiation of Primary Chordoma, Giant Cell Tumor, and Metastatic Tumor of Sacrum Based on T2‐Weighted and Contrast‐Enhanced T1‐Weighted MRI

Background

Preoperative differentiation between primary sacral chordoma (SC), sacral giant cell tumor (SGCT), and sacral metastatic tumor (SMT) is important for treatment decisions.

Purpose

To develop and validate a triple‐classification radiomics model for the preoperative differentiation of SC, SGCT, and SMT based on T2‐weighted fat saturation (T2w FS) and contrast‐enhanced T1‐weighted (CE T1w) MRI.

Study type

Retrospective.

Population

A total of 120 pathologically confirmed sacral patients (54 SCs, 30 SGCTs, and 36 SMTs) were retrospectively analyzed and divided into a training set (n = 83) and a validation set (n = 37).

Field strength/sequence

The 3.0T axial T2w FS and CE T1w MRI.

Assessment

Morphology, intensity, and texture features were assessed based on Formfactor, Haralick, Gray‐level co‐occurrence matrix (GLCM), Gray‐level run‐length matrix (GLRLM), histogram.

Statistical tests

Analysis of variance, least absolute shrinkage and selection operator (LASSO), Pearson correlation, Random Forest (RF), area under the receiver operating characteristic curve (AUC) and accuracy analysis.

Results

The median age of SGCT (33.5, 25.3–45.5) was significantly lower than those of SC (58.0, 48.8–64.3) and SMT (59.0, 46.3–65.5) groups (χ² = 37.6; P < 0.05). No significant difference was found when compared in terms of genders, tumor locations, and tumor sizes of SC, SGCT, and SMT (; P1 = 0.15, P2 = 0.29, P3 = 0.06). For the differential value, features extracted from joint T2w FS and CE T1w images outperformed those from T2w FS or CE T1w images alone. Compared with CE T1w images, features derived from T2w FS images yielded higher AUC in both training and validating set. The best performance of radiomics model based on joint T2w FS and CE T1w images reached an AUC of 0.773, an accuracy of 0.711.

Data conclusion

Our 3.0T MRI‐based triple‐classification radiomics model is feasible to differentiate SC, SGCT, and SMT, which may be applied to improve the precision of preoperative diagnosis in clinical practice.

Level of Evidence: 4

Technical Efficacy: Stage 2

J. Magn. Reson. Imaging 2018.

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Accuracy and precision of proton density fat fraction measurement across field strengths and scan intervals: A phantom and human study

Background

Complex‐based chemical shift imaging‐based magnetic resonance imaging (CSE‐MRI) is emerging as a preferred method for noninvasively quantifying proton density fat fraction (PDFF), a promising quantitative imaging biomarker (QIB) for longitudinal hepatic steatosis measurement.

Purpose

To determine linearity, bias, repeatability, and reproducibility of the PDFF measurement using CSE‐MRI (CSE‐PDFF) across scan intervals, MR field strengths, and readers in phantom and nonalcoholic fatty liver disease (NAFLD) patients.

Study Type

Institutional Review Board (IRB)‐approved prospective.

Subjects

Fat‐water phantom and 20 adult patients.

Field Strength/Sequence

1.5 T and 3.0 T MR systems and a commercially available CSE‐MRI sequence (IDEAL‐IQ).

Assessment

Two independent readers measured CSE‐PDFF of fat‐water phantom and NAFLD patients across two field strengths and scan intervals (same‐day and 2‐week) each and in a combination of both. MR spectroscopy‐based PDFF (MRS‐PDFF) was used as the reference standard for phantom PDFF.

Statistical Tests

Linearity and bias of measurement were evaluated by linear regression analysis and Bland–Altman plots, respectively. Repeatability and reproducibility were assessed by coefficient of variance and repeatability / reproducibility coefficients (RC). The intraclass correlation coefficient was used to validate intra‐ and interobserver agreements.

Results

CSE‐PDFF showed high linearity and small bias (–0.6–0.4 PDFF%) with 95% limits of agreement within ±2.9 PDFF% across field strengths, 2‐week interscan period, and readers in the clinical scans. CSE‐PDFF was highly repeatable and reproducible both in phantom and clinical scans, with the largest observed RC across field strengths and 2‐week interscan period being 3 PDFF%.

Data Conclusion

CSE‐PDFF is a robust QIB with high linearity, small bias, and excellent repeatability/reproducibility. A change of more than 3 PDFF% across field strengths within 2 weeks of scan interval likely reflects a true change, which is well within the clinically acceptable range.

Level of Evidence: 3

Technical Efficacy: Stage 2

J. Magn. Reson. Imaging 2018.

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Basophil Activation Test: Old and New Applications in Allergy

Abstract

Purpose of Review

The basophil activation test (BAT) using flow cytometry has supplanted traditional methods of measuring basophil degranulation using histamine and other mediator release, and can be used for clinical applications as well as to explore the immune mechanisms of effector cell response to allergen. This review discusses the advancements made in clinical, diagnostic and laboratory research of allergy utilizing an ever-evolving BAT.

Recent Findings

Being an in vitro surrogate of the allergic reaction that happens in vivo in the sick patient, the BAT can be used to support the diagnosis of various allergic conditions, such as food, drug, respiratory and insect venom allergies, and the assessment of clinical response to allergen-specific immunotherapy and other immunomodulatory treatments. The BAT can also be used for research purposes to explore the mechanisms of allergy and tolerance at the level of the basophil, for instance by manipulating IgE and IgG and their receptors and by studying intracellular signalling cascade in response to allergen.

Summary

This review covers the applications of the BAT to the clinical management of allergic patients and the increased understanding of the mechanisms of immune response to allergens as well as technological advancements made in recent years.

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Basophil Activation Test: Old and New Applications in Allergy

Abstract

Purpose of Review

The basophil activation test (BAT) using flow cytometry has supplanted traditional methods of measuring basophil degranulation using histamine and other mediator release, and can be used for clinical applications as well as to explore the immune mechanisms of effector cell response to allergen. This review discusses the advancements made in clinical, diagnostic and laboratory research of allergy utilizing an ever-evolving BAT.

Recent Findings

Being an in vitro surrogate of the allergic reaction that happens in vivo in the sick patient, the BAT can be used to support the diagnosis of various allergic conditions, such as food, drug, respiratory and insect venom allergies, and the assessment of clinical response to allergen-specific immunotherapy and other immunomodulatory treatments. The BAT can also be used for research purposes to explore the mechanisms of allergy and tolerance at the level of the basophil, for instance by manipulating IgE and IgG and their receptors and by studying intracellular signalling cascade in response to allergen.

Summary

This review covers the applications of the BAT to the clinical management of allergic patients and the increased understanding of the mechanisms of immune response to allergens as well as technological advancements made in recent years.

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Cochlear joins $17m round for sleep apnea nueromod dev Nyxoah

Cochlear Ltd. (ASX:COH) has joined a $17.1 million (EU €15 million) funding round for Nyxoah to support the development and commercialization of its hypoglossal nerve stim therapy for treating obstructive sleep apnea. Australian hearing tech developer Cochlear lead the round, investing $14.7 million (EU €13 million). The round was also joined by several existing Nyxoah shareholders, the Belgian company said. As part of the funding round, a member of Cochlear has joined Nyxoah's board of directors. "Cochlear actively monitors the market for novel technologies and implantable devices that over the long term may leverage its core business. Nyxoah's minimally invasive solution presents an attractive alternative for patients with compliance or intolerance issues in respec...

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Gruesome footage shows cotton bud being removed from ear after becoming lodged 'for days''

Neel Raithatha extracted the mass at his audiology clinic in Leicestershire. The patient was stunned to find the wool had detached from the stick, causing hearing loss and earache. (Source: the Mail online | Health)

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Cochlear joins $17m round for sleep apnea nueromod dev Nyxoah

Cochlear Ltd. (ASX:COH) has joined a $17.1 million (EU €15 million) funding round for Nyxoah to support the development and commercialization of its hypoglossal nerve stim therapy for treating obstructive sleep apnea. Australian hearing tech developer Cochlear lead the round, investing $14.7 million (EU €13 million). The round was also joined by several existing Nyxoah shareholders, the Belgian company said. As part of the funding round, a member of Cochlear has joined Nyxoah's board of directors. "Cochlear actively monitors the market for novel technologies and implantable devices that over the long term may leverage its core business. Nyxoah's minimally invasive solution presents an attractive alternative for patients with compliance or intolerance issues in respec...

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Gruesome footage shows cotton bud being removed from ear after becoming lodged 'for days''

Neel Raithatha extracted the mass at his audiology clinic in Leicestershire. The patient was stunned to find the wool had detached from the stick, causing hearing loss and earache. (Source: the Mail online | Health)

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Basophil Activation Test: Old and New Applications in Allergy

Abstract

Purpose of Review

The basophil activation test (BAT) using flow cytometry has supplanted traditional methods of measuring basophil degranulation using histamine and other mediator release, and can be used for clinical applications as well as to explore the immune mechanisms of effector cell response to allergen. This review discusses the advancements made in clinical, diagnostic and laboratory research of allergy utilizing an ever-evolving BAT.

Recent Findings

Being an in vitro surrogate of the allergic reaction that happens in vivo in the sick patient, the BAT can be used to support the diagnosis of various allergic conditions, such as food, drug, respiratory and insect venom allergies, and the assessment of clinical response to allergen-specific immunotherapy and other immunomodulatory treatments. The BAT can also be used for research purposes to explore the mechanisms of allergy and tolerance at the level of the basophil, for instance by manipulating IgE and IgG and their receptors and by studying intracellular signalling cascade in response to allergen.

Summary

This review covers the applications of the BAT to the clinical management of allergic patients and the increased understanding of the mechanisms of immune response to allergens as well as technological advancements made in recent years.

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Cochlear joins $17m round for sleep apnea nueromod dev Nyxoah

Cochlear Ltd. (ASX:COH) has joined a $17.1 million (EU €15 million) funding round for Nyxoah to support the development and commercialization of its hypoglossal nerve stim therapy for treating obstructive sleep apnea. Australian hearing tech developer Cochlear lead the round, investing $14.7 million (EU €13 million). The round was also joined by several existing Nyxoah shareholders, the Belgian company said. As part of the funding round, a member of Cochlear has joined Nyxoah's board of directors. "Cochlear actively monitors the market for novel technologies and implantable devices that over the long term may leverage its core business. Nyxoah's minimally invasive solution presents an attractive alternative for patients with compliance or intolerance issues in respec...

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Gruesome footage shows cotton bud being removed from ear after becoming lodged 'for days''

Neel Raithatha extracted the mass at his audiology clinic in Leicestershire. The patient was stunned to find the wool had detached from the stick, causing hearing loss and earache. (Source: the Mail online | Health)

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Basophil Activation Test: Old and New Applications in Allergy

Abstract

Purpose of Review

The basophil activation test (BAT) using flow cytometry has supplanted traditional methods of measuring basophil degranulation using histamine and other mediator release, and can be used for clinical applications as well as to explore the immune mechanisms of effector cell response to allergen. This review discusses the advancements made in clinical, diagnostic and laboratory research of allergy utilizing an ever-evolving BAT.

Recent Findings

Being an in vitro surrogate of the allergic reaction that happens in vivo in the sick patient, the BAT can be used to support the diagnosis of various allergic conditions, such as food, drug, respiratory and insect venom allergies, and the assessment of clinical response to allergen-specific immunotherapy and other immunomodulatory treatments. The BAT can also be used for research purposes to explore the mechanisms of allergy and tolerance at the level of the basophil, for instance by manipulating IgE and IgG and their receptors and by studying intracellular signalling cascade in response to allergen.

Summary

This review covers the applications of the BAT to the clinical management of allergic patients and the increased understanding of the mechanisms of immune response to allergens as well as technological advancements made in recent years.

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Cochlear joins $17m round for sleep apnea nueromod dev Nyxoah

Cochlear Ltd. (ASX:COH) has joined a $17.1 million (EU €15 million) funding round for Nyxoah to support the development and commercialization of its hypoglossal nerve stim therapy for treating obstructive sleep apnea. Australian hearing tech developer Cochlear lead the round, investing $14.7 million (EU €13 million). The round was also joined by several existing Nyxoah shareholders, the Belgian company said. As part of the funding round, a member of Cochlear has joined Nyxoah's board of directors. "Cochlear actively monitors the market for novel technologies and implantable devices that over the long term may leverage its core business. Nyxoah's minimally invasive solution presents an attractive alternative for patients with compliance or intolerance issues in respec...

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Gruesome footage shows cotton bud being removed from ear after becoming lodged 'for days''

Neel Raithatha extracted the mass at his audiology clinic in Leicestershire. The patient was stunned to find the wool had detached from the stick, causing hearing loss and earache. (Source: the Mail online | Health)

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U of Missouri becomes first to ship isotope for thyroid cancer in US

U of Missouri becomes first to ship isotope for thyroid cancer in US  Mass DeviceColumbia becomes sole US supplier of isotope for thyroid cancer treatment  KOMU 8Full coverage

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U of Missouri becomes first to ship isotope for thyroid cancer in US

U of Missouri becomes first to ship isotope for thyroid cancer in US  Mass DeviceColumbia becomes sole US supplier of isotope for thyroid cancer treatment  KOMU 8Full coverage

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Determinants of low measles vaccination coverage in children living in an endemic area

Conclusion: We reported inadequate measles immunization rate in Southern Italy, with lowest rates in children ≤ 2 years or with underlying conditions. Only a minority had true contraindications to vaccine uptake. Implementation strategies addressed to health-care professionals and families should focus on the reported determinants to increase measles vaccination coverage.What is Known:• Measles is a viral, highly communicable disease, preventable by vaccine.• Measles elimination in Europe failed as demonstrated by outbreaks in several countries, due to low immunization rates.What is New:• Inadequate measles immunization rate due to false contraindications in Southern Italy, with lowest rates in children ≤ 2 years.• The presence of underlying disease is a risk factor for i...

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Salvage surgery for a locally persistent or recurrent tumour in maxillary cancer patients who have undergone radiotherapy and concomitant intra-arterial cisplatin: implications for surgical margin assessment

Limited information about salvage surgery is available for locally persistent and recurrent maxillary sinus cancers after the completion of chemoradiation therapy. Seventy-six maxillary sinus cancer patients who had undergone chemoradioselection using initial radiotherapy and concomitant intra-arterial cisplatin were screened retrospectively. Twenty-four of these patients who had a locally persistent or recurrent tumour were investigated. The 2-year overall survival rate of patients with maxillary sinus cancer of all types was 39.0% for those who underwent salvage surgery and 10.0% for those who did not. (Source: International Journal of Oral and Maxillofacial Surgery)

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Determinants of low measles vaccination coverage in children living in an endemic area

Conclusion: We reported inadequate measles immunization rate in Southern Italy, with lowest rates in children ≤ 2 years or with underlying conditions. Only a minority had true contraindications to vaccine uptake. Implementation strategies addressed to health-care professionals and families should focus on the reported determinants to increase measles vaccination coverage.What is Known:• Measles is a viral, highly communicable disease, preventable by vaccine.• Measles elimination in Europe failed as demonstrated by outbreaks in several countries, due to low immunization rates.What is New:• Inadequate measles immunization rate due to false contraindications in Southern Italy, with lowest rates in children ≤ 2 years.• The presence of underlying disease is a risk factor for i...

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Salvage surgery for a locally persistent or recurrent tumour in maxillary cancer patients who have undergone radiotherapy and concomitant intra-arterial cisplatin: implications for surgical margin assessment

Limited information about salvage surgery is available for locally persistent and recurrent maxillary sinus cancers after the completion of chemoradiation therapy. Seventy-six maxillary sinus cancer patients who had undergone chemoradioselection using initial radiotherapy and concomitant intra-arterial cisplatin were screened retrospectively. Twenty-four of these patients who had a locally persistent or recurrent tumour were investigated. The 2-year overall survival rate of patients with maxillary sinus cancer of all types was 39.0% for those who underwent salvage surgery and 10.0% for those who did not. (Source: International Journal of Oral and Maxillofacial Surgery)

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Biologics, Food Allergy Among Hot Topics at ACAAI Meeting

(MedPage Today) -- Immunotherapy, cannabis, antibiotic stewardship will also be discussed (Source: MedPage Today Allergy)

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Biologics, Food Allergy Among Hot Topics at ACAAI Meeting

(MedPage Today) -- Immunotherapy, cannabis, antibiotic stewardship will also be discussed (Source: MedPage Today Allergy)

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Dynamic Postural Stability and Hearing Preservation after Cochlear Implantation

Conclusion: Single-sided cochlear implantation does not adversely affect dynamic postural stability 5 weeks after surgery. Loss of functional residual hearing is not correlated with a decrease in dynamic postural stability.Audiol Neurotol 2018;23:222 –228 (Source: Audiology and Neurotology)

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Dynamic Postural Stability and Hearing Preservation after Cochlear Implantation

Conclusion: Single-sided cochlear implantation does not adversely affect dynamic postural stability 5 weeks after surgery. Loss of functional residual hearing is not correlated with a decrease in dynamic postural stability.Audiol Neurotol 2018;23:222 –228 (Source: Audiology and Neurotology)

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Blended learning modules for lectures on oral and maxillofacial surgery

Over the last couple of years, new teaching methods have been developed and implemented in German universities, but only rarely in dental schools. The aim of this project therefore was to implement students ' requests for such methods to be used in dental education. In 2012, based on an analysis of both quantitative and qualitative requirements, we designed a questionnaire for quantitative analysis, and evaluated a series of lectures on oral and maxillofacial surgery. Based on our findings, we then d esigned a blended learning module that was gradually integrated into the series. (Source: The British Journal of Oral and Maxillofacial Surgery)

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Is injury to the inferior alveolar nerve still common during orthognathic surgery? Manual twist technique for sagittal split ramus osteotomy

The osteotomy in a bilateral sagittal split ramus osteotomy (BSSRO) is made in close proximity to the inferior alveolar nerve (IAN), so direct damage to the nerve and irreversible neurosensory deficit may result. The aim of this study was to compare the incidence of injury to the nerve when a conventional osteotomy using an osteotome was made, with that after manual twist splitting. We retrospectively reviewed the casenotes of 769 consecutive patients who had bilateral SSRO either alone or with a simultaneous maxillary procedure by a single surgeon from May 2009 − October 2016. (Source: The British Journal of Oral and Maxillofacial Surgery)

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Blended learning modules for lectures on oral and maxillofacial surgery

Over the last couple of years, new teaching methods have been developed and implemented in German universities, but only rarely in dental schools. The aim of this project therefore was to implement students ' requests for such methods to be used in dental education. In 2012, based on an analysis of both quantitative and qualitative requirements, we designed a questionnaire for quantitative analysis, and evaluated a series of lectures on oral and maxillofacial surgery. Based on our findings, we then d esigned a blended learning module that was gradually integrated into the series. (Source: The British Journal of Oral and Maxillofacial Surgery)

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Citation for the 2017 BAOMS Surgery prize – Rajiv Anand

Citation for Rajiv Anand (Reg) DOB 17/1/67. (Source: The British Journal of Oral and Maxillofacial Surgery)

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Is injury to the inferior alveolar nerve still common during orthognathic surgery? Manual twist technique for sagittal split ramus osteotomy

The osteotomy in a bilateral sagittal split ramus osteotomy (BSSRO) is made in close proximity to the inferior alveolar nerve (IAN), so direct damage to the nerve and irreversible neurosensory deficit may result. The aim of this study was to compare the incidence of injury to the nerve when a conventional osteotomy using an osteotome was made, with that after manual twist splitting. We retrospectively reviewed the casenotes of 769 consecutive patients who had bilateral SSRO either alone or with a simultaneous maxillary procedure by a single surgeon from May 2009 − October 2016. (Source: The British Journal of Oral and Maxillofacial Surgery)

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Circulating inflammatory biomarkers are related to cerebrovascular disease in older adults

Conclusions Among older adults, increased circulating inflammatory biomarkers were associated with the presence of infarcts and microbleeds, WMH burden, and progression of WMH. (Source: Neurology Neuroimmunology and Neuroinflammation)

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Prevalence of FVIII inhibitors in severe haemophilia A patients: Effect of treatment and genetic factors in an Indian population

ConclusionThe overall prevalence of inhibitors in patients with severe haemophilia A is similar to that reported among patients receiving regular replacement therapy. The data from this study, limited by its retrospective and cross ‐sectional study design, would suggest that genetic rather than environmental are more likely to impact the development of inhibitors. (Source: Haemophilia)

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Circulating inflammatory biomarkers are related to cerebrovascular disease in older adults

Conclusions Among older adults, increased circulating inflammatory biomarkers were associated with the presence of infarcts and microbleeds, WMH burden, and progression of WMH. (Source: Neurology Neuroimmunology and Neuroinflammation)

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Prevalence of FVIII inhibitors in severe haemophilia A patients: Effect of treatment and genetic factors in an Indian population

ConclusionThe overall prevalence of inhibitors in patients with severe haemophilia A is similar to that reported among patients receiving regular replacement therapy. The data from this study, limited by its retrospective and cross ‐sectional study design, would suggest that genetic rather than environmental are more likely to impact the development of inhibitors. (Source: Haemophilia)

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Biologics, Food Allergy Among Hot Topics at ACAAI Meeting

(MedPage Today) -- Immunotherapy, cannabis, antibiotic stewardship will also be discussed (Source: MedPage Today Allergy)

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Biologics, Food Allergy Among Hot Topics at ACAAI Meeting

(MedPage Today) -- Immunotherapy, cannabis, antibiotic stewardship will also be discussed (Source: MedPage Today Allergy)

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Newcastle Jets defender Johnny Koutroumbis returns to training after surgery to remove thyroid cancer

Newcastle Jets defender Johnny Koutroumbis returns to training after surgery to remove thyroid cancer  Daily TelegraphKoutroumbis back and buoyed by fan support  FTBL AustraliaFull coverage

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Lab-on-a-Chip Technologies for Diagnosis and Monitoring of Airway Inflammation

(Source: Journal of Allergy and Clinical Immunology)

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Spectrum of susceptibility to air quality and weather in individual children with atopic dermatitis

ConclusionResponses of AD children to air pollution and weather were considerably variable among individuals. An individualized model would be useful to forecast and manage AD symptoms in patients.This article is protected by copyright. All rights reserved. (Source: Pediatric Allergy and Immunology)

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Feasibility of the Allergy Questionnaire for Athletes (AQUA ©) in pediatric age

This article is protected by copyright. All rights reserved. (Source: Pediatric Allergy and Immunology)

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Newcastle Jets defender Johnny Koutroumbis returns to training after surgery to remove thyroid cancer

Newcastle Jets defender Johnny Koutroumbis returns to training after surgery to remove thyroid cancer  Daily TelegraphKoutroumbis back and buoyed by fan support  FTBL AustraliaFull coverage

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Biologics, Food Allergy Among Hot Topics at ACAAI Meeting

(MedPage Today) -- Immunotherapy, cannabis, antibiotic stewardship will also be discussed (Source: MedPage Today Allergy)

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Biologics, Food Allergy Among Hot Topics at ACAAI Meeting

(MedPage Today) -- Immunotherapy, cannabis, antibiotic stewardship will also be discussed (Source: MedPage Today Allergy)

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Alpha- and gamma-mangostins exhibit anti-acne activities via multiple mechanisms.

CONCLUSIONS: Mangostins appeared to possess multiple anti-acne activities, including the inhibition of P. acnes growth, regulation of keratinocytes proliferation, and attenuation of skin inflammatory reaction. Hence, mangostins might be developed into a potential therapeutic agent for the treatment of acne. PMID: 30422030 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)

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The miRNA 361-3p, a Regulator of GZMB and TNF Is Associated With Therapeutic Failure and Longer Time Healing of Cutaneous Leishmaniasis Caused by L. (viannia) braziliensis

Tain ã S. Lago, Juliana Almeida Silva, Ednaldo L. Lago, Edgar M. Carvalho, Dalila L. Zanette, Léa Cristina Castellucci (Source: Frontiers in Immunology)

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The Usefulness of Aqueous Fluid Analysis for Epstein-Barr Virus in Patients with Uveitis.

CONCLUSION: Low EBV-GWC values combined with multiple positive GWC and/or PCR for other infectious agents. Intraocular assessment for EBV in the initial examination of uveitis patients has limited value. PMID: 30422054 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)

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Monocyte/HDL Ratio and Lymphocyte/Monocyte Ratio in Patients with Pseudoexfoliation Syndrome.

CONCLUSION: We found that there is an association between higher MHR and lower LMR with PEXS. PMID: 30422026 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)

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Development of Secondary Choroidal Neovascularization in Focal Choroidal Excavation of Punctate Inner Choroidopathy.

CONCLUSION: This well-documented case highlighted FCE as the preferential location for CNV development in PIC with multimodal imaging emphasizing a chorioretinal entity. SUMMARY: This case report demonstrated the clinical course of focal choroidal excavation in a patient initially diagnosed with punctate inner choroidopathy complicated by choroidal neovascularization and its treatment response, well documented by multimodal imaging including optical coherence tomography angiography. PMID: 30422049 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)

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Characterization of Natural Killer Cells in HIV Patients Beginning Therapy with a High Burden of Cytomegalovirus.

CONCLUSION: A subpopulation of NK cells expressing NKG2C was induced by CMV replication in HIV patients heterozygous for a deletion in this gene. Individuals with an abundant NKG2C+ and LIR-1+ NK cells displayed lower levels of CMV reactive antibody. PMID: 30422022 [PubMed - as supplied by publisher] (Source: Immunological Investigations)

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Body Mass Index and Mortality in Elderly Subjects from the Moli-Sani Study: A Possible Mediation by Low-Grade Inflammation?

Authors: Crotti G, Gianfagna F, Bonaccio M, Di Castelnuovo A, Costanzo S, Persichillo M, De Curtis A, Cerletti C, Donati MB, de Gaetano G, Iacoviello L, Moli-sani study Investigators Abstract The association between obesity and mortality in the elderly remains controversial. To test the association between BMI and mortality, with the hypothesis of a mediation by low-grade inflammation (LGI), a prospective study design (median follow-up 7.8 years) was used on a sample of 4,970 elderly subjects (age ≥ 65 years) from the Moli-sani Study cohort. The association between BMI categories and overall or cause-specific mortality (hazard ratio, HR) was calculated by multivariable Cox regression. Dose-response relationship was tested using restricted cubic splines. Interaction between BMI an...

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TREX1 D18N mice fail to process erythroblast DNA resulting in inflammation and dysfunctional erythropoiesis.

Authors: Rego SL, Harvey S, Simpson SR, Hemphill WO, McIver ZA, Grayson JM, Perrino FW Abstract Anaemia is commonly observed in chronic inflammatory conditions, including systemic lupus erythematosus (SLE), where ∼50% of patients display clinical signs of anaemia. Mutation at the aspartate residue 18 of the three prime repair exonuclease 1 (TREX1) gene causes a monogenic form of cutaneous lupus in humans and the genetically precise TREX1 D18N mice recapitulate a lupus-like disease. TREX1 degrades single- and double-stranded DNA (dsDNA), and the link between failed DNA degradation by nucleases, including nucleoside-diphosphate kinases (NM23H1/H2) and Deoxyribonuclease II (DNase II), and anaemia prompted our studies to investigate whether TREX1 dysfunction contributes to anaemia. U...

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Less exacerbations and sustained asthma control 12 months after high altitude climate treatment (HACT) for severe asthma

Allergy, Volume 0, Issue ja, -Not available-. (Source: Allergy)

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Hematopoietic cell transplantation for asymptomatic X-linked lymphoproliferative syndrome type 1

X-linked lymphoproliferative disease type 1 (XLP1) is a rare primary immune deficiency, which is caused by SH2D1A gene mutations. XLP1 is commonly associated with Epstein –Barr virus (EBV)-associated hemophagocyti... (Source: Allergy, Asthma and Clinical Immunology)

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Aberrant localization of FOXJ1 correlates with the disease severity and comorbidities in patients with nasal polyps

Upper airway inflammatory diseases are associated with abnormal expression of nasal epithelial forkhead-box J1 (FOXJ1) which regulates motile cilia formation. We sought to investigate whether aberrant FOXJ1 lo... (Source: Allergy, Asthma and Clinical Immunology)

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Mast cell chymase impairs bronchial epithelium integrity by degrading cell ‐junction molecules of epithelial cells

ConclusionsMC ‐chymase plays a key role in inducing the damage to bronchial epithelium in asthma.This article is protected by copyright. All rights reserved. (Source: Allergy)

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Polydatin protects against ovalbumin-induced bronchial asthma in rats; involvement of urocortin and surfactant-D expression.

CONCLUSIONS: Polydatin may be a promising protective agent against experimentally induced bronchial asthma. Modulation of SP-D and UCN expressions seems to mediate such protective effects. PMID: 30422021 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)

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Alpha- and gamma-mangostins exhibit anti-acne activities via multiple mechanisms.

CONCLUSIONS: Mangostins appeared to possess multiple anti-acne activities, including the inhibition of P. acnes growth, regulation of keratinocytes proliferation, and attenuation of skin inflammatory reaction. Hence, mangostins might be developed into a potential therapeutic agent for the treatment of acne. PMID: 30422030 [PubMed - as supplied by publisher] (Source: Immunopharmacology and Immunotoxicology)

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The miRNA 361-3p, a Regulator of GZMB and TNF Is Associated With Therapeutic Failure and Longer Time Healing of Cutaneous Leishmaniasis Caused by L. (viannia) braziliensis

Tain ã S. Lago, Juliana Almeida Silva, Ednaldo L. Lago, Edgar M. Carvalho, Dalila L. Zanette, Léa Cristina Castellucci (Source: Frontiers in Immunology)

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The Usefulness of Aqueous Fluid Analysis for Epstein-Barr Virus in Patients with Uveitis.

CONCLUSION: Low EBV-GWC values combined with multiple positive GWC and/or PCR for other infectious agents. Intraocular assessment for EBV in the initial examination of uveitis patients has limited value. PMID: 30422054 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OGTbRb

Monocyte/HDL Ratio and Lymphocyte/Monocyte Ratio in Patients with Pseudoexfoliation Syndrome.

CONCLUSION: We found that there is an association between higher MHR and lower LMR with PEXS. PMID: 30422026 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)

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Development of Secondary Choroidal Neovascularization in Focal Choroidal Excavation of Punctate Inner Choroidopathy.

CONCLUSION: This well-documented case highlighted FCE as the preferential location for CNV development in PIC with multimodal imaging emphasizing a chorioretinal entity. SUMMARY: This case report demonstrated the clinical course of focal choroidal excavation in a patient initially diagnosed with punctate inner choroidopathy complicated by choroidal neovascularization and its treatment response, well documented by multimodal imaging including optical coherence tomography angiography. PMID: 30422049 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)

MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OJDetK

Characterization of Natural Killer Cells in HIV Patients Beginning Therapy with a High Burden of Cytomegalovirus.

CONCLUSION: A subpopulation of NK cells expressing NKG2C was induced by CMV replication in HIV patients heterozygous for a deletion in this gene. Individuals with an abundant NKG2C+ and LIR-1+ NK cells displayed lower levels of CMV reactive antibody. PMID: 30422022 [PubMed - as supplied by publisher] (Source: Immunological Investigations)

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Body Mass Index and Mortality in Elderly Subjects from the Moli-Sani Study: A Possible Mediation by Low-Grade Inflammation?

Authors: Crotti G, Gianfagna F, Bonaccio M, Di Castelnuovo A, Costanzo S, Persichillo M, De Curtis A, Cerletti C, Donati MB, de Gaetano G, Iacoviello L, Moli-sani study Investigators Abstract The association between obesity and mortality in the elderly remains controversial. To test the association between BMI and mortality, with the hypothesis of a mediation by low-grade inflammation (LGI), a prospective study design (median follow-up 7.8 years) was used on a sample of 4,970 elderly subjects (age ≥ 65 years) from the Moli-sani Study cohort. The association between BMI categories and overall or cause-specific mortality (hazard ratio, HR) was calculated by multivariable Cox regression. Dose-response relationship was tested using restricted cubic splines. Interaction between BMI an...

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New insights into the origin of mast cells

This article is protected by copyright. All rights reserved. (Source: Allergy)

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Feasibility of the Allergy Questionnaire for Athletes (AQUA ©) in pediatric age

This article is protected by copyright. All rights reserved. (Source: Pediatric Allergy and Immunology)

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Less exacerbations and sustained asthma control 12 months after high altitude climate treatment (HACT) for severe asthma

Allergy, Volume 0, Issue ja, -Not available-. (Source: Allergy)

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Cord ‐serum per‐ and poly‐fluoroalkyl substances (PFAS) and atopy and eczema at 12‐months

Allergy, Volume 0, Issue ja, -Not available-. (Source: Allergy)

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Mast cell chymase impairs bronchial epithelium integrity by degrading cell ‐junction molecules of epithelial cells

ConclusionsMC ‐chymase plays a key role in inducing the damage to bronchial epithelium in asthma.This article is protected by copyright. All rights reserved. (Source: Allergy)

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Intranasal Administration of IL-27 Ameliorates Nasal Allergic Responses and Symptoms

Conclusions: This study showed, for the first time, that intranasal administration of IL-27 inhibited nasal allergic responses and symptoms even after the establishment of allergic rhinitis and suggested that IL-27 is useful as an intranasal therapeutic agent.Int Arch Allergy Immunol (Source: International Archives of Allergy and Immunology)

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Recent Advances in Experimental Allergy

Atopic disorders are on the rise and pose a great burden on society. A better understanding of the underlying mechanisms is required for the development of improved or novel therapeutic strategies. Here we aim to highlight recent advances in experimental allergy, with a particular focus on proposed treatment alternatives for airway disorders, atopic dermatitis, and food allergy. Furthermore, we discuss recent work focusing on molecular and cellular mechanisms that might offer candidates for future preventive or therapeutic intervention.Int Arch Allergy Immunol (Source: International Archives of Allergy and Immunology)

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Intranasal Administration of IL-27 Ameliorates Nasal Allergic Responses and Symptoms

Conclusions: This study showed, for the first time, that intranasal administration of IL-27 inhibited nasal allergic responses and symptoms even after the establishment of allergic rhinitis and suggested that IL-27 is useful as an intranasal therapeutic agent.Int Arch Allergy Immunol (Source: International Archives of Allergy and Immunology)

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Recent Advances in Experimental Allergy

Atopic disorders are on the rise and pose a great burden on society. A better understanding of the underlying mechanisms is required for the development of improved or novel therapeutic strategies. Here we aim to highlight recent advances in experimental allergy, with a particular focus on proposed treatment alternatives for airway disorders, atopic dermatitis, and food allergy. Furthermore, we discuss recent work focusing on molecular and cellular mechanisms that might offer candidates for future preventive or therapeutic intervention.Int Arch Allergy Immunol (Source: International Archives of Allergy and Immunology)

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Head and Neck Cancer Market Changing the Outlook for Many Terminal Cancer Patients

Head and Neck Cancer Market Changing the Outlook for Many Terminal Cancer Patients  Coherent Wire (press release) (blog)Head and Neck Cancer Therapeutics Market | Global Industry Analysis, Segments, Top Key Players, Drivers and ...  News by Sharp Reports (press release) (blog)Global Head and Neck Cancer Market Types, Application, Trends, Status and Analysis Research Report 2018-2025  Honest FactsFull coverage

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Head and Neck Cancer Market Changing the Outlook for Many Terminal Cancer Patients

Head and Neck Cancer Market Changing the Outlook for Many Terminal Cancer Patients  Coherent Wire (press release) (blog)Head and Neck Cancer Therapeutics Market | Global Industry Analysis, Segments, Top Key Players, Drivers and ...  News by Sharp Reports (press release) (blog)Global Head and Neck Cancer Market Types, Application, Trends, Status and Analysis Research Report 2018-2025  Honest FactsFull coverage

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The 10,000 Immunomes Project: Building a Resource for Human Immunology

Publication date: 13 November 2018Source: Cell Reports, Volume 25, Issue 7Author(s): Kelly A. Zalocusky, Matthew J. Kan, Zicheng Hu, Patrick Dunn, Elizabeth Thomson, Jeffrey Wiser, Sanchita Bhattacharya, Atul J. Butte (Source: Cell Reports)

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Sodium glucose cotransporter 2 inhibitors and risk of serious adverse events: nationwide register based cohort study

Sodium glucose cotransporter 2 inhibitors and risk of serious adverse events: nationwide register based cohort study  The BMJFull coverage

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Hospital auxiliary raises $90000 for medical equipment and furniture

Hospital auxiliary raises $90000 for medical equipment and furniture  Alberta Daily Herald TribuneFull coverage

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Sodium glucose cotransporter 2 inhibitors and risk of serious adverse events: nationwide register based cohort study

Sodium glucose cotransporter 2 inhibitors and risk of serious adverse events: nationwide register based cohort study  The BMJFull coverage

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Hospital auxiliary raises $90000 for medical equipment and furniture

Hospital auxiliary raises $90000 for medical equipment and furniture  Alberta Daily Herald TribuneFull coverage

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How Much Weight Loss Can Be Expected after Treating Mandibular Fractures?

Surgeons treating facial trauma are faced with a dilemma: fracture healing requires tremendous energy expenditure yet the treatments for mandibular fractures commonly include dietary limitations. Despite this, there are almost no studies attempting to quantify the effect of fracture treatments on patient weight. The purpose of the study was to quantify the effect mandibular fractures and their treatment have on a patient's weight and to identify risk factors associated with increased change.

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Dental Implants Can Facilitate Orthognathic Surgery In A Patient With Severe Maxillary Atrophy

The surgical treatment of dentofacial deformities is performed routinely and predictably on dentate patients. However, when dealing with the edentulous maxilla, treatment becomes more challenging and less predictable. In these cases, the combination of orthognathic surgery (OS) and osseointegrated implants (OI) may be a viable alternative to enable fixed rehabilitation. A patient with an edentulous and atrophic maxilla with maxillo-mandibular discrepancy and high aesthetic requirement, was treated with a combination of osseointergrated implants and orthognathic surgery.

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How Much Weight Loss Can Be Expected after Treating Mandibular Fractures?

Surgeons treating facial trauma are faced with a dilemma: fracture healing requires tremendous energy expenditure yet the treatments for mandibular fractures commonly include dietary limitations. Despite this, there are almost no studies attempting to quantify the effect of fracture treatments on patient weight. The purpose of the study was to quantify the effect mandibular fractures and their treatment have on a patient's weight and to identify risk factors associated with increased change.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2qOQrYF

Dental Implants Can Facilitate Orthognathic Surgery In A Patient With Severe Maxillary Atrophy

The surgical treatment of dentofacial deformities is performed routinely and predictably on dentate patients. However, when dealing with the edentulous maxilla, treatment becomes more challenging and less predictable. In these cases, the combination of orthognathic surgery (OS) and osseointegrated implants (OI) may be a viable alternative to enable fixed rehabilitation. A patient with an edentulous and atrophic maxilla with maxillo-mandibular discrepancy and high aesthetic requirement, was treated with a combination of osseointergrated implants and orthognathic surgery.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2FnGwn3

How Much Weight Loss Can Be Expected after Treating Mandibular Fractures?

Surgeons treating facial trauma are faced with a dilemma: fracture healing requires tremendous energy expenditure yet the treatments for mandibular fractures commonly include dietary limitations. Despite this, there are almost no studies attempting to quantify the effect of fracture treatments on patient weight. The purpose of the study was to quantify the effect mandibular fractures and their treatment have on a patient's weight and to identify risk factors associated with increased change.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2qOQrYF

How Much Weight Loss Can Be Expected after Treating Mandibular Fractures?

Surgeons treating facial trauma are faced with a dilemma: fracture healing requires tremendous energy expenditure yet the treatments for mandibular fractures commonly include dietary limitations. Despite this, there are almost no studies attempting to quantify the effect of fracture treatments on patient weight. The purpose of the study was to quantify the effect mandibular fractures and their treatment have on a patient's weight and to identify risk factors associated with increased change.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2qOQrYF

Dental Implants Can Facilitate Orthognathic Surgery In A Patient With Severe Maxillary Atrophy

The surgical treatment of dentofacial deformities is performed routinely and predictably on dentate patients. However, when dealing with the edentulous maxilla, treatment becomes more challenging and less predictable. In these cases, the combination of orthognathic surgery (OS) and osseointegrated implants (OI) may be a viable alternative to enable fixed rehabilitation. A patient with an edentulous and atrophic maxilla with maxillo-mandibular discrepancy and high aesthetic requirement, was treated with a combination of osseointergrated implants and orthognathic surgery.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2FnGwn3

Dental Implants Can Facilitate Orthognathic Surgery In A Patient With Severe Maxillary Atrophy

The surgical treatment of dentofacial deformities is performed routinely and predictably on dentate patients. However, when dealing with the edentulous maxilla, treatment becomes more challenging and less predictable. In these cases, the combination of orthognathic surgery (OS) and osseointegrated implants (OI) may be a viable alternative to enable fixed rehabilitation. A patient with an edentulous and atrophic maxilla with maxillo-mandibular discrepancy and high aesthetic requirement, was treated with a combination of osseointergrated implants and orthognathic surgery.

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Newcastle Jets defender Johnny Koutroumbis returns to training after surgery to remove thyroid cancer

Newcastle Jets defender Johnny Koutroumbis returns to training after surgery to remove thyroid cancer  Daily TelegraphFull coverage

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KING HUSSEIN CANCER CENTER

KING HUSSEIN CANCER CENTER  Europe & Middle East Outlook Magazine (blog)Full coverage

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Clinical characteristics and prognosis of serous body cavity effusions in patients with sepsis: a retrospective observational study

Abstract

Background

Cavity effusion is common in patients with infectious diseases. However, the incidence rate and characteristics of serous cavity effusions (SCE) in septic patients are not clear to date. The objective of this study was to investigate the incidence and characteristics of SCE in septic patients and to explore the correlations between the bloody effusions and the illness severity/prognosis in septic patients.

Methods

From January 2010 to January 2015, a total of 214 patients with severe sepsis and septic shock were enrolled in this retrospective observational study. Thoracentesis or abdominal paracentesis was performed in 45 septic patients because of massive pleural effusions or ascites. The serum concentrations of VEGF, VEGFR, Ang, sICAM-1, sVCAM-1, E-selectin, Serpine1 and VE-cadherin in 45 septic patients underwent paracentesis were measured by enzyme-linked immunosorbent assay (ELISA).

Results

Of the 214 septic patients, 155 (72.4%) had SCE according to imaging or ultrasound manifestations. 45 subjects with SCE underwent therapeutic thoracentesis or abdominal paracentesis. Effusion laboratory analysis showed that exudates were predominant when compared with transudates (95.6% vs. 4.4%), and 16 (35.6%) patients suffered bloody effusions. Compared with patients with non-bloody effusions, those with bloody effusions showed higher critical illness scores (13 vs. 17 for APACHE II; 7 vs. 9 for SOFA), and higher mortality (6.9% vs. 62.5%). Moreover, patients with bloody effusions had delayed TT and APTT, increased D-dimer concentration, and higher serum levels of CRP and PCT (P < 0.05). In addition, the serum levels of Ang2, sVCAM-1 and E-selectin were significantly higher in patients with bloody effusions than in those with non-bloody effusions (P < 0.05). However, the serum level of VEGFR2 was lower in patients with bloody fluids (P = 0.025).

Conclusions

The incidence of serous cavity effusion is high in patients with sepsis. The septic patients with bloody effusions suffer a more inflammatory burden and a worse prognosis compared to septic patients with non-bloody effusions.

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Newcastle Jets defender Johnny Koutroumbis returns to training after surgery to remove thyroid cancer

Newcastle Jets defender Johnny Koutroumbis returns to training after surgery to remove thyroid cancer  Daily TelegraphFull coverage

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KING HUSSEIN CANCER CENTER

KING HUSSEIN CANCER CENTER  Europe & Middle East Outlook Magazine (blog)Full coverage

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Clinical characteristics and prognosis of serous body cavity effusions in patients with sepsis: a retrospective observational study

Abstract

Background

Cavity effusion is common in patients with infectious diseases. However, the incidence rate and characteristics of serous cavity effusions (SCE) in septic patients are not clear to date. The objective of this study was to investigate the incidence and characteristics of SCE in septic patients and to explore the correlations between the bloody effusions and the illness severity/prognosis in septic patients.

Methods

From January 2010 to January 2015, a total of 214 patients with severe sepsis and septic shock were enrolled in this retrospective observational study. Thoracentesis or abdominal paracentesis was performed in 45 septic patients because of massive pleural effusions or ascites. The serum concentrations of VEGF, VEGFR, Ang, sICAM-1, sVCAM-1, E-selectin, Serpine1 and VE-cadherin in 45 septic patients underwent paracentesis were measured by enzyme-linked immunosorbent assay (ELISA).

Results

Of the 214 septic patients, 155 (72.4%) had SCE according to imaging or ultrasound manifestations. 45 subjects with SCE underwent therapeutic thoracentesis or abdominal paracentesis. Effusion laboratory analysis showed that exudates were predominant when compared with transudates (95.6% vs. 4.4%), and 16 (35.6%) patients suffered bloody effusions. Compared with patients with non-bloody effusions, those with bloody effusions showed higher critical illness scores (13 vs. 17 for APACHE II; 7 vs. 9 for SOFA), and higher mortality (6.9% vs. 62.5%). Moreover, patients with bloody effusions had delayed TT and APTT, increased D-dimer concentration, and higher serum levels of CRP and PCT (P < 0.05). In addition, the serum levels of Ang2, sVCAM-1 and E-selectin were significantly higher in patients with bloody effusions than in those with non-bloody effusions (P < 0.05). However, the serum level of VEGFR2 was lower in patients with bloody fluids (P = 0.025).

Conclusions

The incidence of serous cavity effusion is high in patients with sepsis. The septic patients with bloody effusions suffer a more inflammatory burden and a worse prognosis compared to septic patients with non-bloody effusions.

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Hematopoietic cell transplantation for asymptomatic X-linked lymphoproliferative syndrome type 1

X-linked lymphoproliferative disease type 1 (XLP1) is a rare primary immune deficiency, which is caused by SH2D1A gene mutations. XLP1 is commonly associated with Epstein–Barr virus (EBV)-associated hemophagocyti...

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Aberrant localization of FOXJ1 correlates with the disease severity and comorbidities in patients with nasal polyps

Upper airway inflammatory diseases are associated with abnormal expression of nasal epithelial forkhead-box J1 (FOXJ1) which regulates motile cilia formation. We sought to investigate whether aberrant FOXJ1 lo...

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Hematopoietic cell transplantation for asymptomatic X-linked lymphoproliferative syndrome type 1

X-linked lymphoproliferative disease type 1 (XLP1) is a rare primary immune deficiency, which is caused by SH2D1A gene mutations. XLP1 is commonly associated with Epstein–Barr virus (EBV)-associated hemophagocyti...

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Aberrant localization of FOXJ1 correlates with the disease severity and comorbidities in patients with nasal polyps

Upper airway inflammatory diseases are associated with abnormal expression of nasal epithelial forkhead-box J1 (FOXJ1) which regulates motile cilia formation. We sought to investigate whether aberrant FOXJ1 lo...

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Changing Developmental Trajectories of Toddlers With Autism Spectrum Disorder: Strategies for Bridging Research to Community Practice.

Conclusions: Current health care and education systems are challenged to provide intervention of adequate intensity for toddlers with ASD. The use of innovative technology can increase acceleration of access to evidence-based early intervention for toddlers with ASD that addresses health disparities, enables immediate response as soon as ASD is suspected, and rapidly bridges the research-to-practice gap. PMID: 30418491 [PubMed - in process] (Source: Journal of speech, language, and hearing research : JSLHR)

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Mast cell chymase impairs bronchial epithelium integrity by degrading cell‐junction molecules of epithelial cells

Abstract

Background

An increased degree of mast cell (MC) degranulation and damage to the epithelial lining are prominent features of bronchial asthma. In asthmatic airways, it seems likely that epithelial cells will be exposed to increased concentrations of proteases from MC, though their actions on the epithelium are still not very clear.

Methods

Bronchial rings from human lung tissue or 16HBE cell monolayer were incubated with MC‐chymase in different doses or various inhibitors. The sections of paraffin‐embedded tissue were haematoxylin‐eosin stained and computerized by image analysis for epithelial damage‐scale‐evaluation; the cell viability, proliferation, adhesion, LDH release were assayed; the expressions of gelatinases, cell‐junction molecules and structure proteins of 16HBE were examined.

Results

MC‐Chymase was found to provoke profound changes in the morphology of bronchi epithelial layer. Following incubation with chymase there was 40% reduction of the length of epithelium that was intact, with detachment of columnar epithelial cells and basal cells. Chymase reduced epithelial cell proliferation and induced cell detachment, which were associated with the changes in secretion and activation of matrix metalloproteinase‐2/9. In intact epithelial cell layers, immunocytochemistry study revealed that chymase reduced the expressions of occludin, claudin‐4, ZO‐1, E‐cadherin, focal adhesion kinase and cytokeratin. Overall data of this study indicated that MC‐chymase can influence tissue remodelling, disrupt epithelial cell‐junctions, inhibit wound healing and impair the barrier function of epithelium, resulting in dysfunction of airway wall and ECM remodelling in pathogenesis of asthma.

Conclusions

MC‐chymase plays a key role in inducing the damage to bronchial epithelium in asthma.

This article is protected by copyright. All rights reserved.

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Less exacerbations and sustained asthma control 12 months after high altitude climate treatment (HACT) for severe asthma

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Less exacerbations and sustained asthma control 12 months after high altitude climate treatment (HACT) for severe asthma

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2FwoJtE

Cord‐serum per‐ and poly‐fluoroalkyl substances (PFAS) and atopy and eczema at 12‐months

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New insights into the origin of mast cells

Abstract

Single‐cell RNA‐sequencing and colony‐forming assays suggest that bone marrow hematopoietic stem and progenitor cells traverse through a differentiation landscape before commitment to the mast cell and other cell lineages.¹ However, the bone marrow contribution for the formation of tissue‐resident mast cells has been questioned, and the prenatal origin of mast cells was recently uncovered.² Through fate mapping experiments Gentek et al² elegantly demonstrated that mast cells arise during two distinct waves of the embryonic development, one from the yolk sac and the other via the aorta‐gonad‐mesonephros.

This article is protected by copyright. All rights reserved.

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Salvage surgery for a locally persistent or recurrent tumour in maxillary cancer patients who have undergone radiotherapy and concomitant intra-arterial cisplatin: implications for surgical margin assessment

Limited information about salvage surgery is available for locally persistent and recurrent maxillary sinus cancers after the completion of chemoradiation therapy. Seventy-six maxillary sinus cancer patients who had undergone chemoradioselection using initial radiotherapy and concomitant intra-arterial cisplatin were screened retrospectively. Twenty-four of these patients who had a locally persistent or recurrent tumour were investigated. The 2-year overall survival rate of patients with maxillary sinus cancer of all types was 39.0% for those who underwent salvage surgery and 10.0% for those who did not.

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Vanillic acid mitigates the ovalbumin (OVA)-induced asthma in rat model through prevention of airway inflammation.

Authors: Bai F, Fang L, Hu H, Yang Y, Feng X, Sun D Abstract Asthma is a chronic allergic ailment affecting a considerably large population of the world. The aim of this study is to evaluate the ameliorative effects of vanillic acid against ovalbumin (OVA)-induced asthma in rat model. Asthma was induced in Sprague Dawley rats and vanillic acid was orally administered at 25 and 50 mg/kg body weight for 28 days. Rats challenged with OVA showed heavy signs of airway inflammation and remodeling similar to chronic asthma, evidenced by the increased differential cell counts and presence of inflammatory cytokines in the bronchoalveolar lavage fluid (BALF), along with elevated serum immunoglobulin levels, and the histological results. However, vanillic acid dose-dependently attenuated the...

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Salvage surgery for a locally persistent or recurrent tumour in maxillary cancer patients who have undergone radiotherapy and concomitant intra-arterial cisplatin: implications for surgical margin assessment

Limited information about salvage surgery is available for locally persistent and recurrent maxillary sinus cancers after the completion of chemoradiation therapy. Seventy-six maxillary sinus cancer patients who had undergone chemoradioselection using initial radiotherapy and concomitant intra-arterial cisplatin were screened retrospectively. Twenty-four of these patients who had a locally persistent or recurrent tumour were investigated. The 2-year overall survival rate of patients with maxillary sinus cancer of all types was 39.0% for those who underwent salvage surgery and 10.0% for those who did not.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2qKBIxE

Vanillic acid mitigates the ovalbumin (OVA)-induced asthma in rat model through prevention of airway inflammation.

Authors: Bai F, Fang L, Hu H, Yang Y, Feng X, Sun D Abstract Asthma is a chronic allergic ailment affecting a considerably large population of the world. The aim of this study is to evaluate the ameliorative effects of vanillic acid against ovalbumin (OVA)-induced asthma in rat model. Asthma was induced in Sprague Dawley rats and vanillic acid was orally administered at 25 and 50 mg/kg body weight for 28 days. Rats challenged with OVA showed heavy signs of airway inflammation and remodeling similar to chronic asthma, evidenced by the increased differential cell counts and presence of inflammatory cytokines in the bronchoalveolar lavage fluid (BALF), along with elevated serum immunoglobulin levels, and the histological results. However, vanillic acid dose-dependently attenuated the...

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Lab-on-a-Chip Technologies for Diagnosis and Monitoring of Airway Inflammation

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Lab-on-a-Chip Technologies for Diagnosis and Monitoring of Airway Inflammation

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Skin shop: A new model for high volume skin cancer care

Non-melanoma skin cancer incidence is increasing in New Zealand. Increased cost of care has led to service pressure and a review of models of care. A high volume skin surgery service at Waikato Hospital has been developed to reduce service costs. This study examines the oncological safety of the new model.

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Modified bolster dressing with continuous suction improves skin graft survival for an oral cavity wound

Skin engraftment of intraoral defects is known to be inconsistent due to mobility of the oral structure, uneven wounds, and accumulation of saliva under the skin graft. To improve the success rate of oral skin...

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Silicone-based simulation models for peripheral nerve microsurgery

There is a need for a peripheral nerve model on which surgeons-in-training can simulate the repair of nerve injuries at their own pace. Although practicing on animal models/cadavers is considered the "gold standard" of microsurgical training, the proposed model aims to provide a platform for improving the technical skills of surgical trainees prior to their practice on cadaver/animal models. In addition, this model has the potential to serve as a standardized test medium for assessing the skill sets of surgeons.

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Skin shop: A new model for high volume skin cancer care

Non-melanoma skin cancer incidence is increasing in New Zealand. Increased cost of care has led to service pressure and a review of models of care. A high volume skin surgery service at Waikato Hospital has been developed to reduce service costs. This study examines the oncological safety of the new model.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Fk66cj

Modified bolster dressing with continuous suction improves skin graft survival for an oral cavity wound

Skin engraftment of intraoral defects is known to be inconsistent due to mobility of the oral structure, uneven wounds, and accumulation of saliva under the skin graft. To improve the success rate of oral skin...

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Blended learning modules for lectures on oral and maxillofacial surgery

Over the last couple of years, new teaching methods have been developed and implemented in German universities, but only rarely in dental schools. The aim of this project therefore was to implement students' requests for such methods to be used in dental education. In 2012, based on an analysis of both quantitative and qualitative requirements, we designed a questionnaire for quantitative analysis, and evaluated a series of lectures on oral and maxillofacial surgery. Based on our findings, we then designed a blended learning module that was gradually integrated into the series.

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