Switchable control over in vivo CAR T expansion, B cell depletion, and induction of memory [Immunology and Inflammation]

Chimeric antigen receptor (CAR) T cells with a long-lived memory phenotype are correlated with durable, complete remissions in patients with leukemia. However, not all CAR T cell products form robust memory populations, and those that do can induce chronic B cell aplasia in patients. To address these challenges, we previously... (Source: Proceedings of the National Academy of Sciences)

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