Successful Anti-PD-1 Cancer Immunotherapy Requires T Cell-Dendritic Cell Crosstalk Involving the Cytokines IFN- γ and IL-12

Anti-PD-1 mAbs can induce sustained clinical responses in cancer but how they function in  vivo remains incompletely understood. Garris et al. show that effective anti-PD-1 immunotherapy requires intratumoral dendritic cells (DCs) producing IL-12. Anti-PD-1 indirectly activates DCs through IFN-γ released from drug-activated T cells. Furthermore, agonizing the non-canonical NF-κB pat hway activates DCs and enhances aPD-1 therapy in an IL-12-dependent manner. (Source: Immunity)

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