Response to the Letter to the Editor regarding “Impact of crack cocaine use on the occurrence of oral lesions and micronuclei”

We are grateful for the interest in our study "Impact of crack cocaine use on the occurrence of oral lesions and micronuclei"1. Firstly, regarding the criticism that Giemsa stain can cause false-positive results, we agree that this method may provide an overestimate of the presence of micronuclei. However, any misclassification would be non -differential, as a difference in the overestimation between groups is not plausible. Thus, this type of error would bias the results towards the null hypothesis2 and therefore does not account for the differences described in our study between crack users and non-users. (Source: International Journal of Oral and Maxillofacial Surgery)

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