Immunological characteristics of Mycobacterium tuberculosis subunit vaccines immunized through different routes

Publication date: Available online 6 September 2018Source: Microbial PathogenesisAuthor(s): Yanzhi Lu, Jian Kang, Huanhuan Ning, Lifei Wang, Yanhui Xu, Ying Xue, Zhikai Xu, Xingan Wu, Yinlan BaiAbstractTuberculosis is chronic infectious disease caused by Mycobacterium tuberculosis (M.tb) that is prevalent worldwide. Several specific antigens, such as Antigen 85B (Ag85B) and 6 kDa early secretory antigenic target (ESAT-6) protein of M.tb, are listed as some of the candidate subunit vaccines against M.tb. ESAT-6, as a virulent factor and differential gene in M.tb, shows insufficient immunogenicity in animal model. In order to investigate the ways to improve the immunogenicity of ESAT-6, we immunized ESAT-6 by subcutaneous and intramuscular routes with different adjuvants. We found that ESA...

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