Harmonization of Terminology for Tolerated and Reactive Dose in Food Allergy Immunotherapy

Publication date: Available online 14 December 2018Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Thomas B. Casale, Tmirah Haselkorn, Christina E. Ciaccio, Panida Sriaroon, Bradley E. ChippsAbstractCurrently, there is no FDA-approved therapy for food allergy. Several new potential treatments are under investigation, including food allergen immunotherapy via various routes of administration, such as oral immunotherapy, epicutaneous therapy, subcutaneous immunotherapy, and sublingual immunotherapy. The double-blind, placebo-controlled food challenge has traditionally been used for diagnostic purposes, but extrapolation of the specific terminology used in food allergy diagnosis to interpretation of efficacy in clinical trials is incongruent and difficult to appl...

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