Loss of Gimap5 promotes pathogenic CD4+ T cell development and allergic airway disease

GIMAP5 LOF mutations in both mice and humans are associated with polarization of CD4+ T cells towards TH17 and TH2 cells in vivo. Gimap5-deficient mice develop more severe allergic airway disease upon HDM sensitization. (Source: Journal of Allergy and Clinical Immunology)

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