Proinsulin C-peptide is an autoantigen in people with type 1 diabetes [Immunology and Inflammation]

Type 1 diabetes (T1D) is an autoimmune disease in which insulin-producing beta cells, found within the islets of Langerhans in the pancreas, are destroyed by islet-infiltrating T cells. Identifying the antigenic targets of beta-cell reactive T cells is critical to gain insight into the pathogenesis of T1D and develop antigen-specific... (Source: Proceedings of the National Academy of Sciences)

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