Frequency of CD8 + regulatory T cells in the multiple sclerosis patients: a systematic review and meta-analysis

AbstractMultiple sclerosis (MS) is a neuro-immunological demyelinating disease. From the immunological aspects, it is well accepted that T cells play a pivotal role in the etiology of the disease. T helper (Th) 1 and Th17 cells are thought to be the main pathogenic T cells in the pathogenesis of MS and are known as effector T cells. As the self-reactive T lymphocytes can escape clonal deletion in the thymus and subsequently are released into the periphery, there is an urgent need for peripheral tolerance, which is executed by the specialized regulatory T (Treg) cells. Interestingly, CD8+ regulatory T (Treg) cells have also been identified among lymphocyte subtypes. The peripheral CD8+ Treg cells frequency in MS subjects in comparison with healthy controls is the objective of the current st...

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