Topical drugs containing chloramphenicol and clostridiopeptidase A are frequently used for the treatment of cutaneous ulcers and other necrotic lesions. Chloramphenicol is a bacteriostatic broad‐spectrum antibiotic widely used in eye and skin ointments to treat bacterial infections and a well‐known cause of allergic contact dermatitis (ACD) (1). Clostridiopeptidase A, also called collagenase 1, is a proteolytic enzyme facilitating the tissue granulation with consequent re‐epithelization; it has rarely been reported as cause of ACD (2).
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