A hyperactive mutant of Interferon-Regulatory-Factor 4.

Authors: Kang CH, Hartmann E, Menke L, Staudenraus D, Abass EF, Raifer H, Porapu A, Camara B, Brüstle A, Pinkenburg O, Bieringer M, Lohoff M Abstract IRFs are a family of transcription factors with pleiotropic functions in immune cells, including in generation of subsets of DCs and macrophages and B cell maturation [1]. IRF1 deficiency results in strongly diminished Th1 responses [2] and an inability to counteract pro-asthmatic Th9 responses [3]. PMID: 30218581 [PubMed - as supplied by publisher] (Source: European Journal of Immunology)

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