Endometrial transcripts of proinflammatory cytokine and enzymes in prostaglandin synthesis are upregulated in the bitches with atrophic pyometra

Publication date: Available online 25 October 2018Source: Veterinary Immunology and ImmunopathologyAuthor(s): Laishram Kipjen Singh, Manas Kumar Patra, Girish Kumar Mishra, Vidya Singh, Vikramaditya Upmanyu, Abhishek C. Saxena, Sanjay Kumar Singh, Goutam Kumar Das, Harendra Kumar, Narayanan KrishnaswamyAbstractInflammatory markers of endometrial origin are valuable in order to differentiate the pyometra from cystic endometrial hyperplasia in the bitch. In the present study, we hypothesized that histological categorization would distinguish the differential regulation of the proinflammatory genes in the endometrium of bitches with pyometra. Ovariohysterectomy was done on bitches with confirmatory diagnosis of pyometra (n = 18). Using endometrium to myometrium ratio of 0.79 as threshold,...

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