Integrins αvβ5 and αvβ6 Mediate IL-4-Induced Collective Migration in Human Airway Epithelial Cells.

Authors: Lee SN, Ahn JS, Lee SG, Park JA, Lee HS, Choi AMK, Yoon JH Abstract A positive link between persistent cellular motion and a defective tight junction (TJ) barrier allows increased antigenic penetration and contact between ligand/receptor pairs, leading to exacerbated allergic airway inflammation and remodeling. Given that collective cell migration involves cell-cell and cell-extracellular matrix (ECM) adhesions, and that interleukin-4 (IL-4) induces epithelial barrier dysfunction and decreases cell-ECM adhesions, we hypothesized that IL-4 may induce collective migration in the well-differentiated primary human nasal epithelial cells (HNECs). Well-differentiated HNECs were treated with IL-4 and the effects of IL-4 on cell migration were investigated using genetic and pharma...

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