Abramson Developing CAR T-Cell Therapy for Mesothelioma

The National Cancer Institute awarded a five-year, $10.7 million grant to the Abramson Cancer Center at the University of Pennsylvania to develop CAR T-cell therapy for mesothelioma and lung cancer. The hopes are high for a breakthrough. The program involves a laboratory modification of a patient's T cells — a type of white blood cell — that prompts the immune system to attack cancer cells. The therapy also is known as chimeric antigen receptor T-cell therapy. It already is revolutionizing the way some blood and bone marrow cancers are treated. The grant is designed to investigate whether this type of gene therapy can do the same for solid tumors such as mesothelioma. "CAR T cells have completely changed the way we treat leukemia, so the hope is that yes, over the next decade we ca...

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