The Effects of Ozone Therapy on Periodontal Therapy: A Randomized Placebo‐Controlled Clinical Trial

Abstract

Objectives

The aim of this randomized split‐mouth clinical trial was to evaluate the effects of ozone therapy on clinical and biochemical parameters of moderate to severe generalized periodontitis patients after non‐surgical periodontal therapy.

Methods

A total of 36 moderate to severe generalized periodontitis patients were included in the study. The patients were systemically healthy and 18 to 64 years of age. Periodontal parameters, including plaque index (PI), gingival index (GI), probing depth (PD), percentage of bleeding on probing, percentage of pockets deeper than 5 mm and clinical attachment level (CAL), and percentage of ≥3 mm CAL were evaluated at baseline and 3 months following periodontal therapy. All participants were treated non‐surgically. Topical gaseous ozone was applied into periodontal pockets twice a week for 2 weeks during active periodontal therapy. Gingival crevicular fluid pentraxin‐3 (PTX‐3), interleukin‐1β (IL‐1β) and high sensitivity C‐reactive protein (Hs‐CRP) were evaluated. All statistical data were analyzed using SPSS software.

Results

Total of 36 participants completed the study (18 males, 18 females). PI, GI, PD, percentage of bleeding on probing, percentage of pockets deeper than 5mm and CAL, and percentage of ≥3 mm CAL, were improved, and there were no significant differences between the two sides. All inflammatory parameters, PTX‐3, Hs‐CRP and IL‐1β, were reduced at 3‐months follow‐up. Only the decrease in PTX‐3 levels between baseline and 3‐months follow‐up was statistically significant.

Conclusions

Ozone therapy did not have any additional effect on periodontal parameters. All cytokines were reduced after periodontal therapy. Only PTX‐3 levels were significantly lower at ozone sites compared to those at the control sites.

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