A comparison of systemic and local dexamethasone administration: From perilymph/cochlea concentration to cochlear distribution.

Authors: Wang Y, Han L, Diao T, Jing Y, Wang L, Zheng H, Ma X, Qi J, Yu L Abstract Different types of inner ear diseases can damage different cochlear subsites by different mechanisms. Steroids administered by different methods are commonly used for treating inner ear diseases. There is reason to believe that dexamethasone (Dex) may reach cochlear subsite targets via different pathways after administration by different methods: Intratympanic (IT), postaural (PA), and intraperitoneal (IP). The purpose of this study was to explore the cochlear concentration and distribution of Dex after administration by different methods. High-performance liquid chromatography-mass spectrometry and immunofluorescence technology were employed to measure and compare the Dex concentration in the perily...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2ML7jIq