Potential therapeutic role of Co-Q10 in alleviating intervertebral disc degeneration and suppressing IL-1 β-mediated inflammatory reaction in NP cells.

Potential therapeutic role of Co-Q10 in alleviating intervertebral disc degeneration and suppressing IL-1β-mediated inflammatory reaction in NP cells. Int Immunopharmacol. 2018 Sep 24;64:424-431 Authors: Wang X, Meng Q, Qiu C, Li P, Qu R, Wang W, Wang Y, Liu L, Zhao Y Abstract Coenzyme Q10 (Co-Q10) is extraordinarily popular and has been used in abundant interventions as an antioxidant reagent that participates in numerous oxidation reactions. According to substantial evidence previously reported, interleukin-1β (IL-1β) is deemed to be one of the chief orchestrator molecules in the degeneration of intervertebral disc (IVD). However, it is unknown whether Co-Q10 is able to protect against IVD degeneration. In the current study, mouse-derived IVDs as well as primary h...

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