Ulinastatin mediates suppression of regulatory T cells through TLR4/NF- κB signaling pathway in murine sepsis.

Ulinastatin mediates suppression of regulatory T cells through TLR4/NF-κB signaling pathway in murine sepsis. Int Immunopharmacol. 2018 Sep 24;64:411-423 Authors: Cao C, Yin C, Chai Y, Jin H, Wang L, Shou S Abstract CD4+CD25+ regulatory T cells (Tregs) play an essential role in the suppression of the immune response and prevention of autoimmune reactions. The activation of TLR4, which provides a critical link between the innate and adaptive immune systems, has been implicated in regulating the function of Tregs. Ulinastatin (UTI) is a broad-spectrum protease inhibitor that has been shown to modulate innate immunity and pro-inflammatory signaling in sepsis. In addition, there are reports that UTI may modulate the functional activity of Tregs to influence the inflammato...

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