Advances in Immune Pathways and Pathogenesis of Atopic Dermatitis

AbstractPurpose of ReviewAtopic dermatitis (AD) is a common chronic skin inflammatory disorder characterized by recurrent eczema accompanied by an intractable itch that leads to an impaired quality of life. This review aims to summarize the advances in immune pathways and pathogenesis of AD.Recent FindingsWe review and summarize the current literature characterizing immune pathways and pathogenesis of AD. The complex interplay among skin barrier deficiency, immunological derangement, microbiome dysbiosis especiallyStaphylococcus aureus predominance, and pruritus contribute to the development, progression, and chronicity of the disease.SummaryAD is a complex and multifactorial disease. The skin barrier, dysbiosis of the skin microbiome, immune dysregulation, and severe itch all play a part ...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2q4WVlG