Correlation between DNA/HSA-interactions and antimalarial activity of acridine derivatives: Proposing a possible mechanism of action

Publication date: Available online 19 October 2018Source: Journal of Photochemistry and Photobiology B: BiologyAuthor(s): Marina de M. Silva, Taís S. Macedo, Helena Mariana P. Teixeira, Diogo Rodrigo M. Moreira, Milena B.P. Soares, Ana Ligia da C. Pereira, Vanessa de L. Serafim, Francisco J.B. Mendonça-Júnior, Maria do Carmo A. de Lima, Ricardo O. de Moura, Edeildo F. da Silva-Júnior, João Xavier de Araújo-Júnior, Maria Dayanne de A. Dantas, Eduarda de O. O. Nascimento, Thamilla Maria S. Maciel, Thiago Mendonça de Aquino, Isis M. Figueiredo, Josué C.C. SantosAbstractAcridines are considered an important class of compounds due to their wide variety of biological activities. In this work, we synthesized four acridine derivatives (1–4) and evaluated their biological activity agains...

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