GSE74375 Interleukin 2 distinctly activates human basophils in skin disorders

Contributors : Shuli Zhao ; Antonio Lentini ; Yelin Zhao ; Mikael Benson   ; Hui WangSeries Type : Expression profiling by arrayOrganism : Homo sapiensBasophils are important effector cells in allergic inflammation, anti-parasitic immune response and skin disorders. A number of activators including interleukin 3 (IL-3) and IgE have been identified in the regulation of human basophils expressing mediators such as histamine and leukotriene C4 (LTC4) and cytokines, including IL-4 and IL-13. Human basophils express high levels of IL-2 receptors. However, the function of the IL-2 pathway in basophils remains unknown. Here, we identify that IL-2-stimulated human basophils in vitro express a variety of inflammatory cytokines and chemokines including IL-5, IL-13, GM-CSF and CCL-17. Of note, one o...

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