Hepatitis C Virus in Women of Childbearing Age, Pregnant Women, and Children

Publication date: November 2018

Source: American Journal of Preventive Medicine, Volume 55, Issue 5

Author(s): Sarah F. Schillie, Lauren Canary, Alaya Koneru, Noele P. Nelson, Wade Tanico, Harvey W. Kaufman, Susan Hariri, Claudia J. Vellozzi

Introduction

Perinatal transmission is an increasingly important mode of hepatitis C virus transmission. The authors characterized U.S. births among hepatitis C virus–infected women and evaluated trends in hepatitis C virus testing and positivity in women of childbearing age, pregnant women, and children aged less than 5years.

Methods

In 2017, National Center for Health Statistics birth certificate data (48 states and District of Columbia) were analyzed to assess the number of hepatitis C virus–infected women delivering live births in 2015, and commercial laboratory data were analyzed to assess hepatitis C virus testing and positivity among women of childbearing age, pregnant women, and children aged <5years from 2011 to 2016.

Results

In 2015, a total of 0.38% (n=14,417) of live births were delivered by hepatitis C virus–infected women. Births delivered by hepatitis C virus–infected women, compared with births overall, occurred more often in women who were aged 20–29years (60.7% vs 50.9%); white, non-Hispanic (80.2% vs 52.8%); covered by Medicaid or other government insurance (79.2% vs 43.9%); and had rural residence (26.0% vs 14.0%). From 2011 to 2016 laboratory data, among women of childbearing age, hepatitis C virus testing increased by 39%, from 6.1% to 8.4%, and positivity increased by 36%, from 4.4% to 6.0%. Among pregnant women, hepatitis C virus testing increased by 135%, from 5.7% to 13.4%, and positivity increased by 39%, from 2.6% to 3.6%. Among children, hepatitis C virus testing increased by 25%, from 0.47% to 0.59%, and positivity increased by 13%, from 3.6% to 4.0%.

Conclusions

The potential for perinatal hepatitis C virus transmission exists. Expanded hepatitis C virus testing guidelines may address the burden of disease in this population.

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