IL-33 mediates allergy through mast cell activation: Potential inhibitory effect of certain cytokines.

Authors: Tettamanti L, Kritas SK, Gallenga CE, D'Ovidio C, Mastrangelo F, Ronconi G, Caraffa A, Toniato E, Conti P Abstract Mast cells (MCs) are hematopoietic immune cells commonly found in adjacent to blood vessels in the lamina propria of airway mucosa. They are important in allergic reactions since the cross-linking of their surface high affinity receptor FceRI induces activation of these cells, and provokes the synthesis, degranulation and release of inflammatory mediators including arachidonic acid-derived eicosanoids (de novo synthesized), stored enzyme mediators, and inflammatory TH1 and TH2 cytokines, and chemokines. Interleukin (IL)-33 participates in innate and adaptive immunity and inflammation and, acting on CD34+ cells, causes MC differentiation and maturation. IL-33 i...

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